American Chemical Suppliers
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Product | Description | |
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Jingzhaotoxin III Quick inquiry Where to buy Suppliers range | Jingzhaotoxin III is a selective blocker of NaV1.5 channels with IC50 value of 348 nM. It is selective for NaV1.5 channels and shows no effect on other isoforms. It inhibits the activation of cardiac sodium channels by binding to the NaV1.5 S3-S4 linker of domain II. It has no effect on sodium channels in dorsal root ganglion neurons. Synonyms: H-Asp-Gly-Glu-Cys(1)-Gly-Gly-Phe-Trp-Trp-Lys-Cys(2)-Gly-Arg-Gly-Lys-Pro-Pro-Cys(3)-Cys(1)-Lys-Gly-Tyr-Ala-Cys(2)-Ser-Lys-Thr-Trp-Gly-Trp-Cys(3)-Ala-Val-Glu-Ala-Pro-OH; L-alpha-aspartyl-glycyl-L-alpha-glutamyl-L-cysteinyl-glycyl-glycyl-L-phenylalanyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-lysyl-L-prolyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-lysyl-glycyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-seryl-L-lysyl-L-threonyl-L-tryptophyl-glycyl-L-tryptophyl-L-cysteinyl-L-alanyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-proline (4->19),(11->24),(18->31)-tris(disulfide). Grades: >98%. CAS No. 925463-91-8. Molecular formula: C174H241N47O46S6. Mole weight: 3918.44. | |
Jingzhaotoxin III Quick inquiry Where to buy Suppliers range | Jingzhaotoxin-III selectively inhibits the activation of the voltage-dependent Nav1.5 channels (IC50 = 350 nM) in heart or cancer cells, but displays no effect on other isoforms,like NaV1.2, NaV1.4, NaV1.6 and NaV1.7. It also inhibits Kv2.1 channel (IC50 = 700 nM). Uses: Peptide Inhibitors. CAS No. 925463-91-8. Product ID: R0983. | |
Jionoside A1 Quick inquiry Where to buy Suppliers range | Jionoside A1. Group: Biochemicals. CAS No. 120444-60-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Jionoside B1 Quick inquiry Where to buy Suppliers range | Jionoside B1. Group: Biochemicals. Grades: Plant Grade. CAS No. 120406-37-3. Pack Sizes: 5mg. Molecular Formula: C37H50O20, Molecular Weight: 814.79. US Biological Life Sciences. | Worldwide |
JIP-1 (153-163) Quick inquiry Where to buy Suppliers range | JIP-1 (153-163) has been found to be a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Synonyms: TI-JIP. Grades: >98%. CAS No. 438567-88-5. Molecular formula: C61H104N20O14. Mole weight: 1341.6. | |
JIP-1 (153-163) Quick inquiry Where to buy Suppliers range | Selective peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Uses: Peptide Inhibitors. CAS No. 438567-88-5. Product ID: R0970. | |
JIP-1 (153-163) acetate Quick inquiry Where to buy Suppliers range | JIP-1 (153-163) acetate is a c-Jun N-terminal kinase (JNK) peptide inhibitor based on JNK-interacting protein-1 (JIP-1) residues 153-163. It binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Synonyms: L-Phenylalaninamide, L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparaginyl-L-leucyl-, acetate (1:1); H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparagyl-L-leucyl-L-phenylalaninamide acetate salt. Grades: ≥95%. CAS No. 1417623-78-9. Molecular formula: C61H104N20O14.C2H4O2. Mole weight: 1401.66. | |
JJH260 Quick inquiry Where to buy Suppliers range | JJH260 is an inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). JJH260 was shown to found members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism. Synonyms: 7-(4-(dimethylamino)benzoyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-chlorophenethyl)piperidine-1-carboxylate. Grades: ≥90%. CAS No. 1831135-30-8. Molecular formula: C29H34ClN5O5. Mole weight: 568.1. | |
JJKK 048 Quick inquiry Where to buy Suppliers range | JJKK 048, a benzodioxol derivative, has been found to a MAGL inhibitor that could probably be significant in anticancer and anti-inflammatory studies. IC50: 0.4 nM. Synonyms: JJKK048; JJKK-048; JJKK 048; MolPort-035-941-193; BDBM50065646; AKOS025142062; ZINC103287208; [4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1515855-97-6. Molecular formula: C23H22N4O5. Mole weight: 434.44. | |
JJKK 048 Quick inquiry Where to buy Suppliers range | JJKK 048. Group: Biochemicals. Grades: Purified. CAS No. 1515855-97-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
JK 184 Quick inquiry Where to buy Suppliers range | JK 184. Group: Biochemicals. Grades: Purified. CAS No. 315703-52-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
JK-184 Quick inquiry Where to buy Suppliers range | JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity. Uses: Differentiation. Synonyms: JK184; JK 184. Grades: 98%. CAS No. 315703-52-7. Molecular formula: C19H18N4OS. Mole weight: 350.44. | |
JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine) Quick inquiry Where to buy Suppliers range | An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). Group: Biochemicals. Alternative Names: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine. Grades: Highly Purified. CAS No. 315703-52-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
JKC 363 Quick inquiry Where to buy Suppliers range | JKC 363. Group: Biochemicals. Grades: Purified. CAS No. 436083-30-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
JKC 363 Quick inquiry Where to buy Suppliers range | JKC 363 has been found to be a melanocortin MC4 receptor antagonist and could suppress the release of thyrotropin-releasing hormone (TRH). Synonyms: (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide; JKC363; JKC-363; 3-Mercaptopropionyl-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond); deamino-Cys-Glu-His-D-2Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asn-OH (Disulfide bridge: Cys1-Cys8); deamino-cysteinyl-L-alpha-glutamyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-asparagine (1->8)-disulfide; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-; [Deamino-Cys11,β-(2-Naphthyl)-D-Ala14,Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22. Grades: ≥95% by HPLC. CAS No. 436083-30-6. Molecular formula: C69H91N19O16S2. Mole weight: 1506.72. | |
JK-P3 Quick inquiry Where to buy Suppliers range | JK-P3 is a VEGFR2 inhibitor with IC50 values of 7.8 μM. JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but exhibits no effect on FGFR signaling in cell-based assays. It suppresses wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. Synonyms: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide. CAS No. 942655-44-9. Molecular formula: C18H17N3O3. Mole weight: 323.352. | |
JLK 6 Quick inquiry Where to buy Suppliers range | JLK 6. Group: Biochemicals. Grades: Purified. CAS No. 62252-26-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
JLK 6 Quick inquiry Where to buy Suppliers range | JLK 6, under the IUPAC name 7-amino-4-chloro-3-methoxyisochromen-1-one, an inhibitor of γ-secretase (IC50 = between 10 μM-1 mM) that belongs to the class of isocoumarin analogs, prevents recovery of Aβ40 and Aβ42 (IC50 < 100 μM) in HEK293 cells overexpressing wild-type and Swedish-mutant β-amyloid precursor protein (APP). Synonyms: JCP-251; JCP 251; JCP251 7-amino-4-chloro-3-methoxyisochromen-1-one; 7-Amino-4-chloro-3-methoxyisocoumarin; jlk6; 62252-26-0; JLK 6; 7-Amino-4-chloro-3-methoxy-isocoumarin; gamma-Secretase Inhibitor XI; 7-amino-4-chloro-3-methoxyisochromen-1-one; AC1L1GQZ; AC1Q3FXG; JLK-6; CHEMBL149518; SCHEMBL3056620; CTK2F1888; AMDGKLWVCUXONP-UHFFFAOYSA-N; HMS3269N03; ZINC2523036; AR-1H3136; ZINC02523036; 7-amino-3-methoxy-4-chloroisocoumarin; AKOS024457236; NCGC00167827-01; AK396360; HE005374; HE366264; TX-017351; 7-Amino-4-chloro-3-methoxy-isochromen-1-one; 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one; 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-; BRD-K22010301-001-01-2; JLK 6|7-Amino-4-chloro-3-methoxy-1H-2-benzopyran; JLK 6; 7-AMINO-4-CHLORO-3-METHOXY-1H-2-BENZOPYRAN. CAS No. 62252-26-0. Molecular formula: C10H8ClNO3. Mole weight: 225.63. | |
JM-6 Quick inquiry Where to buy Suppliers range | JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO). It could increase kynurenic acid levels and reduces extracellular glutamate in the brain. It prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease. It also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease. It also plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including Alzheimer's and Huntington's diseases. Uses: Jm6 plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including alzheimer's and huntington's diseases. Synonyms: JM6; JM-6; JM 6. 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide;2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole. Grades: >98 %. CAS No. 1008119-83-2. Molecular formula: C23H26N4O6S2. Mole weight: 518.60. | |
JM6 Quick inquiry Where to buy Suppliers range | ≥97% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1008119-83-2. Pack Sizes: 5MG, 25MG. Mole weight: 518.61. Catalog: AP1008119832. Assay: ≥97% (HPLC). | |
JMJD Histone Demethylase Inhibitor III ( (E) -4- (Hydroxy (4- (4- ( (naphthalen-1-ylcarbamoyloxy) methyl) benzylamino) butyl) amino) -4-oxobut-2-enoic Acid) Quick inquiry Where to buy Suppliers range | A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
JMJD Histone Demethylase Inhibitor IV, Methylstat ( (E) -Methyl-4- (hydroxy (4- ( (4- ( ( (naphthalen-1-ylcarbamoyl) oxy) methyl) benzyl) amino) butyl) amino) -4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) Quick inquiry Where to buy Suppliers range | A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
JMS 17-2 hydrochloride Quick inquiry Where to buy Suppliers range | JMS 17-2 is a CX3CR1 antagonist. Inhibition of CX3CR1 by JMS 17-2 was indicated to impair metastatic seeding and colonization of breast cancer cells. Synonyms: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H26ClN3O·HCl. Mole weight: 456.41. | |
JMV3002 Quick inquiry Where to buy Suppliers range | JMV3002 is an endogenous ligand for the growth hormone secretagogue receptor (GHSR). It decreased food intake in fasted lean mice in a dose-dependent manner with ED50 value of 2.05 mg/kg, suggesting its potential use in diet-induced obesity (DIO) treatment. Synonyms: N-[1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]pyridine-2-carboxamide. Grades: ≥98%. CAS No. 925239-03-8. Molecular formula: C35H34N6O3. Mole weight: 586.7. | |
JMV 390-1 Quick inquiry Where to buy Suppliers range | JMV 390-1 has been found to be an inhibitor of the major neurotensin and neuromedin N degrading enzymes and could probably show analgesic activities. Synonyms: Jmv-390-1; Jmv390-1; N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 148473-36-3. Molecular formula: C23H35N3O6. Mole weight: 449.54. | |
JMV 390-1 Quick inquiry Where to buy Suppliers range | JMV 390-1. Group: Biochemicals. Grades: Purified. CAS No. 148473-36-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
JMV 390-1 Quick inquiry Where to buy Suppliers range | JMV 390-1 inhibits multiple neurotensin and neuromedin N degrading enzymes. Uses: Peptide Inhibitors. CAS No. 148473-36-3. Product ID: R0908. | |
JMV 449 Quick inquiry Where to buy Suppliers range | JMV 449 could be a neurotensin receptor agonist peptide and has been found to show hypothermic and analgesic activities in the mouse. Synonyms: JMV-449; JMV449; (S)-1-de-L-lysine-2-[N2-(2,6-diaminohexyl)-L-lysine]-neuromedin N (pig spinal cord); H-Lysy(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH. Grades: ≥95% by HPLC. CAS No. 139026-66-7. Molecular formula: C38H66N8O7. Mole weight: 746.96. | |
JMV 449 Quick inquiry Where to buy Suppliers range | JMV 449. Group: Biochemicals. Grades: Purified. CAS No. 139026-66-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
JNJ 0966 Quick inquiry Where to buy Suppliers range | JNJ 0966 is a selective inhibitor of MMP-9 (IC50 = 440 nM) with no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity. JNJ 0966 was indicated to alleviate the pain of experimental autoimmune encephalomyelitis in a mouse model. Synonyms: JNJ-0966; JNJ0966; N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide. Grades: ≥98% by HPLC. CAS No. 315705-75-0. Molecular formula: C16H16N4O2S2. Mole weight: 360.45. | |
JNJ 10181457 Quick inquiry Where to buy Suppliers range | JNJ 10181457. Group: Biochemicals. Alternative Names: 4- [3- [4- [Piperidinyl] but-1-ynyl] benzyl] morpholine. Grades: Highly Purified. CAS No. 544707-19-9. Pack Sizes: 10mg. Molecular Formula: C20H28N2O, Molecular Weight: 312.45. US Biological Life Sciences. | Worldwide |
JNJ10181457 Quick inquiry Where to buy Suppliers range | JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 receptors respectively. It increases acetylcholine and extracellular norepinephrine levels in rat frontal cortex, but it does not stimulate dopamine release. It normalizes acetylcholine neurotransmission and shows efficacy in translational rat models of cognition. Uses: Jnj10181457 dihydrochloride normalizes acetylcholine neurotransmission. Synonyms: JNJ-10181457; JNJ10181457; JNJ 10181457; JNJ-10181457 dihydrochloride;4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine dihydrochloride. Grades: >98 %. CAS No. 544707-19-9. Molecular formula: C20H28N2O. Mole weight: 312.4. | |
JNJ 10181457 dihydrochloride Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of JNJ 10181457, which has been found to be a histamine H3 receptor inhibitor and could be a brain penetrant. Synonyms: JNJ 10181457 dihydrochloride; JNJ10181457 dihydrochloride; JNJ-10181457 dihydrochloride; 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 544707-20-2. Molecular formula: C20H28N2O.2HCl. Mole weight: 385.37. | |
JNJ-10191584 Quick inquiry Where to buy Suppliers range | JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and analgesic effects in animal studies of acute inflammation. No development was reported for the treatment of Allergic rhinitis, Atopic dermatitis, Pruritus and Respiratory tract disorders. Uses: Allergic rhinitis; atopic dermatitis; pruritus; respiratory tract disorders. Synonyms: JNJ-10191584; JNJ10191584; JNJ 10191584; VUF-6002; VUF 6002; VUF6002; (5-Chloro-1H-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone;869497-75-6(maleate). Grades: 98%. CAS No. 73903-17-0. Molecular formula: C13H15ClN4O. Mole weight: 278.74. | |
JNJ 10191584 maleate Quick inquiry Where to buy Suppliers range | JNJ 10191584 maleate. Group: Biochemicals. Grades: Purified. CAS No. 869497-75-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
JNJ 10191584 maleate Quick inquiry Where to buy Suppliers range | The maleate salt form of JNJ 10191584, which has been found to be a selective histamine H4 receptor silent antagonist and could restrain mast cell and eosinophil chemotaxis in vitro. Synonyms: VUF6002; VUF 6002; VUF-6002; JNJ-10191584 maleate; JNJ 10191584 maleate; JNJ10191584 maleate; 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate. Grades: ≥99% by HPLC. CAS No. 869497-75-6. Molecular formula: C13H15ClN4O.C4H4O4. Mole weight: 394.81. | |
JNJ-10198409 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC), solid. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 627518-40-5. Pack Sizes: 1MG, 5MG. Mole weight: 325.34. Catalog: AP627518405-A. Assay: ≥98% (HPLC). | |
JNJ10229570 Quick inquiry Where to buy Suppliers range | JNJ10229570 is a novel MC1R and MC5R antagonist. It was used to treat primary human sebaceous cells. It might have a potential for the treatment of acne and other sebaceous gland pathologies. It was developed by Johnson & Johnson. It was in phase II clinical trials, but has been terminated. Uses: Jnj10229570 was used to treat primary human sebaceous cells. it might have a potential for the treatment of acne and other sebaceous gland pathologies. Synonyms: JNJ-10229570; JNJ10229570; JNJ 10229570; UNII-N9IX402L35;2,3-Bis(2-methoxyphenyl)-N-phenyl-1,2,4-thiadiazol-5-imine;Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-. Grades: 98%. CAS No. 524923-88-4. Molecular formula: C22H19N3O2S. Mole weight: 389.47. | |
JNJ-10258859 Quick inquiry Where to buy Suppliers range | JNJ-10258859 is a novel, potent, and selective phosphodiesterase type 5 inhibitor 5 with a K(I) of 0.23 nM and displayed excellent selectivity versus phosphodiesterase types 1-4. Uses: Phosphodiesterase type 5 inhibitor. Synonyms: JNJ-10258859; JNJ 10258859; JNJ10258859; UNII-4NPX9224XR. (3R)-3-(2,3-dihydro-1-benzofuran-5-yl)-2-[5-(4-methoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one. Grades: ≥98%. CAS No. 374927-03-4. Molecular formula: C30H24N4O3. Mole weight: 488.54. | |
JNJ10311795 Quick inquiry Where to buy Suppliers range | JNJ10311795 is a dual inhibitor of Chymase and leukocyte Proteases Cathepsin G. It has inflammation therapeutic efficacy in animals models. Uses: Jnj10311795 has inflammation therapeutic efficacy. Synonyms: JNJ-10311795; JNJ 10311795; JNJ10311795. [2-[3-[Methyl-[1-(naphthalene-2-carbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid;Phosphonic acid, (2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naph. Grades: 98%. CAS No. 518062-14-1. Molecular formula: C40H35N2O6P. Mole weight: 670.70. | |
JNJ-10329670 Quick inquiry Where to buy Suppliers range | JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM). Uses: Immunosuppressant. Synonyms: JNJ-10329670; JNJ 10329670; JNJ10329670. 1-(3-(4-(6-chloro-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)-4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-1H-Pyrazolo(4,3-C)pyridine. Grades: ≥98%. CAS No. 400797-24-2. Molecular formula: C30H34ClF3N6O3S. Mole weight: 651.14. | |
JNJ 10397049 Quick inquiry Where to buy Suppliers range | JNJ 10397049. Group: Biochemicals. Alternative Names: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)urea. Grades: Highly Purified. CAS No. 708275-58-5. Pack Sizes: 1mg. Molecular Formula: C19H20Br2N2O3, Molecular Weight: 484.18. US Biological Life Sciences. | Worldwide |
JNJ-10397049 Quick inquiry Where to buy Suppliers range | JNJ-10397049 is a selective orexin-2 receptor (OX2) antagonist. pIC50 is 7.4 for chimeric OX2 receptors/ pKB values are 5.9 for OX1 and 8.5 for OX2 receptors respectively. JNJ-10397049 exhibits no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. It achieves high level of OX2 receptor occupancy in the rat brain. Synonyms: JNJ-10397049; JNJ 10397049; JNJ10397049; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-(1,3)dioxan-5-yl)urea. Grades: 98%. CAS No. 708275-58-5. Molecular formula: C19H20Br2N2O3. Mole weight: 484.19. | |
JNJ-1250132 Quick inquiry Where to buy Suppliers range | JNJ-1250132, a new steroidal progestin antagonist, inhibits binding of the receptor to DNA in vitro. JNJ-1250132 induces a receptor conformation more similar to that induced by mifepristone, which promotes receptor binding to DNA. Synonyms: [(8S,11R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-11-(4-piperidin-1-ylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; JNJ-1250132; JNJ 1250132; JNJ1250132. Grades: >98%. CAS No. 240805-96-3. Molecular formula: C33H41NO4. Mole weight: 515.68. | |
JNJ 16259685 Quick inquiry Where to buy Suppliers range | JNJ 16259685, a pyrano-quinolin derivative, has been found to be a metabotropic glutamate receptor-1 antagonist. Synonyms: JNJ16259685; JNJ 16259685; JNJ-16259685; (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone. Grades: ≥98% by HPLC. CAS No. 409345-29-5. Molecular formula: C20H23NO3. Mole weight: 325.41. | |
JNJ 16259685 Quick inquiry Where to buy Suppliers range | JNJ 16259685. Group: Biochemicals. Alternative Names: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone. Grades: Highly Purified. CAS No. 409345-29-5. Pack Sizes: 10mg. Molecular Formula: C20H23NO3, Molecular Weight: 325.399999999999. US Biological Life Sciences. | Worldwide |
JNJ 1661010 Quick inquiry Where to buy Suppliers range | JNJ 1661010. Group: Biochemicals. Grades: Purified. CAS No. 681136-29-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
JNJ-1661010 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 365.45. Catalog: IAR4241656. Assay: ≥98% (HPLC). | |
JNJ-1661010 Quick inquiry Where to buy Suppliers range | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. Synonyms: Takeda-25; N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; JNJ 1661010; JNJ1661010; N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. Grades: ≥98%. CAS No. 681136-29-8. Molecular formula: C19H19N5OS. Mole weight: 365.45. | |
JNJ 17029259 Quick inquiry Where to buy Suppliers range | JNJ 17029259 is an selective, nanomolar inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2), blocks VEGF-stimulated mitogen-activated protein kinase signaling, proliferation/migration. Uses: Vascular endothelial growth factor receptor-2 (vegf-2) kinase inhibitor. Synonyms: JNJ-17029259; JNJ 17029259; JNJ17029259. 4-[4-(2-aminopropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethyl)anilino]pyrimidine-5-carbonitrile. Grades: ≥98%. CAS No. 314267-57-7. Molecular formula: C26H30N6O. Mole weight: 442.56. | |
JNJ17156516 Quick inquiry Where to buy Suppliers range | JNJ17156516 is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516; JNJ 17156516; JNJ17156516; (S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid. Grades: 98%. CAS No. 649551-06-4. Molecular formula: C26H22Cl2N2O3. Mole weight: 481.37. | |
JNJ17156516 sodium Quick inquiry Where to buy Suppliers range | JNJ17156516 sodium is the sodium salt form of JNJ17156516, which is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516 sodium; JNJ 17156516 sodium; JNJ17156516 sodium; 1H-Pyrazole-3-propanoic acid, 5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-alpha-(3-methylphenyl)-, sodium salt (1:1), (alphaS)-;(S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid sodium s. Grades: 98%. CAS No. 648861-58-9. Molecular formula: C26H21Cl2N2NaO3. Mole weight: 503.35. | |
JNJ 17203212 Quick inquiry Where to buy Suppliers range | JNJ 17203212. Group: Biochemicals. Grades: Purified. CAS No. 821768-06-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
JNJ-17203212 Quick inquiry Where to buy Suppliers range | JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human TRPV1 and rat TRPV1. It could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. It inhibits capsaicin- and H+-induced channel activation, which pIC50 values are 6.32 and 7.23 respectively. It exhibits antitussive and analgesic activity in vivo. Uses: Jnj-17203212 could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. it inhibits capsaicin- and h+-induced channel activation. it exhibits antitussive and analgesic activity in vivo. Synonyms: JNJ-17203212; JNJ 17203212; JNJ17203212. 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide;1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-;N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine. Grades: >99 %. CAS No. 821768-06-3. Molecular formula: C17H15F6N5O. Mole weight: 419.32. | |
JNJ-19567470 Quick inquiry Where to buy Suppliers range | JNJ-19567470 is a selective Corticotropin releasing factor (CRF) receptor antagonist. It is a novel target for developing anti-panic drugs. JNJ-19567470 is as effective as benzodiazepines in treatment of a panic attack which prevents sodium lactate-induced acute panic-like responses. In Oct 2009, preclinical development in Anxiety disorders was ongoing in Japan. Uses: Anxiety disorders. Synonyms: JNJ-19567470; JNJ19567470; JNJ 19567470; TAI-041; TAI 041; TAI041; R-317573;1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-4-Piperidinemethanol. Grades: 98%. CAS No. 724471-26-5. Molecular formula: C22H27BrN4O. Mole weight: 443.38. | |
JNJ 20788560 Quick inquiry Where to buy Suppliers range | JNJ-20788560 is a delta opioid agonist analgesics. No recent reports of development identified for preclinical development in Inflammatory-pain in USA. Uses: Inflammatory pain; pain. Synonyms: JNJ-20788560; JNJ 20788560; JNJ20788560; 9-(8-Azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide. Grades: 98%. CAS No. 825649-28-3. Molecular formula: C25H28N2O2. Mole weight: 388.51. | |
JNJ-2408068 Quick inquiry Where to buy Suppliers range | JNJ-2408068 is a potent inhibitor of respiratory syncytial virus (RSV), exhibits potent antiviral activity with 50% effective concentrations (EC50s) of 1.4 and 2.1 nM, respectively. Uses: Respiratory syncytial virus inhibitor. Synonyms: R170591; R-170591; R 170591; HE066500; HE-066500; HE 066500; JNJ-2408068; JNJ 2408068; JNJ2408068. 2-[[2-[[1-(2-aminoethyl)piperidin-4-yl]amino]-4-methylbenzimidazol-1-yl]methyl]-6-methylpyridin-3-ol. Grades: ≥98%. CAS No. 317846-22-3. Molecular formula: C22H30N6O. Mole weight: 394.52. | |
JNJ26076713 Quick inquiry Where to buy Suppliers range | JNJ26076713 is an orally active alpha V integrin antagonist. It may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Uses: Jnj26076713 may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Synonyms: JNJ-26076713; JNJ26076713; JNJ 26076713;3-Quinolinepropanoic acid, 1,2,3,4-tetrahydro-beta-((1-(1-oxo-3-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)propyl)-4-piperidinyl)methyl)-, (betaS,3S)-;(3S)-4-[1-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoyl]piperidin-4-yl]-3-[(3S)-1,2. Grades: 98%. CAS No. 669076-03-3. Molecular formula: C29H38N4O3. Mole weight: 490.65. | |
JNJ-26146900 Quick inquiry Where to buy Suppliers range | JNJ-26146900 is a selective, nonsteroidal androgen receptor modulator with tissue-selective activity in rats. It can bind to the rat AR with a Ki of 400nM and act as a pure androgen antagonist in an in vitro cell-based assay. But no development was reported for the treatment of Bone disorders and Cancer till now. Uses: Bone disorders; cancer. Synonyms: JNJ-26146900; JNJ 26146900; JNJ26146900. (-)(R)-2-(2-Ethylsulfonyl-1-hydroxy-1-methylethyl)-6-trifluoromethyl-1H-indole-5-carbonitrile. Grades: 98%. CAS No. 868691-50-3. Molecular formula: C15H15F3N2O3S. Mole weight: 360.35. | |
Jnj-26481585 Quick inquiry Where to buy Suppliers range | Jnj-26481585. Group: Heterocyclic Organic Compound. Alternative Names: JNJ-26481585;N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine;N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide;Quisinostat;N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carbox;N-Hydroxy-2-(4-((((1-Methyl-1H-indol-3-yl)Methyl)aMino)Methyl)piperidin-1-yl)pyriMidine-5-carboxaMide;Quisinostat (JNJ-26481585);Quisinostat (JNJ-26481585) 2HCl. CAS No. 875320-29-9. Molecular formula: C21H26N6O2. Mole weight: 394.47014. Density: 1.35. | |
JNJ 26481585 dihydrochloride Quick inquiry Where to buy Suppliers range | JNJ 26481585 dihydrochloride is a potent and second-generation pan-HDAC inhibitor (IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with antineoplastic activity. JNJ-26481585 inhibiting HDAC leads to continuous acetylation of histone H3, activation of the caspase cascade, upregulation of p21, and tumor cell apoptosis. Uses: Antitumor agent. Synonyms: JNJ 26481585 dihydrochloride; JNJ26481585 dihydrochloride; JNJ-26481585 dihydrochloride; Quisinostat HCl; N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride. Grades: 99%. CAS No. 875320-31-3. Molecular formula: C21H26N6O2.2HCl. Mole weight: 467.39. | |
JNJ-26483327 Quick inquiry Where to buy Suppliers range | JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). Synonyms: JNJ-26483327; JNJ 26483327; JNJ26483327. CAS No. 807640-87-5. Molecular formula: C22H25BrN4O2. Mole weight: 457.372. | |
JNJ26483327 dihydrobromide Quick inquiry Where to buy Suppliers range | JNJ26483327 is an orally bioavailable multitargeted reversible tyrosine kinase inhibitor. It binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, Src family kinases and vascular endothelial growth factor receptor type 3 (VEGFR3). It has potential antineoplastic activity. It may inhibit tumor growth, invasion, migration and metastasis by inhibiting several different signaling molecules. Uses: Jnj26483327 has potential antineoplastic activity and may inhibit tumor growth, invasion, migration and metastasis. Synonyms: (Z)-35-bromo-17-methoxy-5-methyl-13,14-dihydro-11-oxa-2,5-diaza-1(4,6)-quinazolina-3(1,2)-benzenacycloundecaphane;JNJ 26483327; JNJ-26483327; JNJ26483327. Grades: >98 %. CAS No. 1021686-80-5. Molecular formula: C22H27Br3N4O2. Mole weight: 619.19. | |
JNJ-26489112 Quick inquiry Where to buy Suppliers range | JNJ-26489112 is a CNS active agent that can be used to treat depression and photosensitive epilepsy. Synonyms: JNJ26489112; JNJ 26489112. CAS No. 871824-55-4. Molecular formula: C9H11ClN2O4S. Mole weight: 278.71. | |
JNJ 26854165 dihydrochloride Quick inquiry Where to buy Suppliers range | JNJ 26854165 dihydrochloride is a HDM2 inhibitor. It potently inhibits multiple myeloma (MM) cells and mantle cell lymphoma (MCL). In addition, JNJ 26854165 suppresses the mutant (mut) p53 cell lines and results in apoptosis. Synonyms: Serdemetan dihydrochloride; N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine dihydrochloride. Grades: 99%. CAS No. 2109414-74-4. Molecular formula: C21H20N4.2HCl. Mole weight: 401.33. | |
JNJ 27141491 Quick inquiry Where to buy Suppliers range | JNJ 27141491 is a potent and selective human CCR2 antagonist. Synonyms: JNJ27141491; JNJ 27141491; JNJ-27141491; 4,4-difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide; maraviroc; Pfizer Brand of maraviroc; Selzentry; UK-427,857; UK-427857. CAS No. 871313-59-6. Molecular formula: C17H15F2N3O3S. Mole weight: 379.38. | |
JNJ 27141491 Quick inquiry Where to buy Suppliers range | JNJ 27141491. Group: Biochemicals. Grades: Purified. CAS No. 871313-59-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
JNJ-28312141 Quick inquiry Where to buy Suppliers range | JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Synonyms: JNJ28312141; JNJ 28312141; 4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide. CAS No. 885692-52-4. Molecular formula: C26H32N6O2. Mole weight: 460.58. | |
JNJ 28871063 hydrochloride Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of JNJ 28871063, which has been found to be a nonquinazoline Pan-ErbB kinase inhibitor and probably could restrain the growth of human tumor xenografts. Synonyms: JNJ28871063 hydrochloride; JNJ-28871063 hydrochloride; 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride; 5-Pyrimidinecarboxaldehyde, 4-amino-6-[[3-chloro-4-(phenylmethoxy)phenyl]amino]-, O-[2-(4-morpholinyl)ethyl]oxime, hydrochloride (1:1), [C(E)]-; JNJ 28871063; (E)-4-amino-6-((4-(benzyloxy)-3-chlorophenyl)amino)pyrimidine-5-carbaldehyde O-(2-morpholinoethyl) oxime hydrochloride. Grades: ≥97% by HPLC. CAS No. 944342-90-9. Molecular formula: C24H27ClN6O3.HCl. Mole weight: 519.42. | |
JNJ 28871063 hydrochloride Quick inquiry Where to buy Suppliers range | JNJ 28871063 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 944342-90-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |