BOC Sciences 2 - Products
BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description |
|---|---|
| AX-024 hydrochloride Quick inquiry Where to buy |
AX-024 hydrochloride is an inhibitor of T cell receptor (TCR) that selectively inhibits the TCR-Nck interaction. By modulating TCR signaling, AX-024 prevents the development of psoriasis and asthma and, furthermore, exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. Synonyms: AX-024 HCl; AX 024 hydrochloride; AX024 hydrochloride; AX-024 hydrochloride; 1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine hydrochloride. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1704801-24-0. Molecular formula: C21H22FNO2.HCl. Mole weight: 375.86. |
| AX 048 Quick inquiry Where to buy |
8) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. . Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. |
| AX-15836 Quick inquiry Where to buy |
AX-15836 is a highly potent and selective ERK5 inhibitor (IC50 = 8 nM) with >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Synonyms: 2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methyl-11-methylsulfonylpyrimido[4,5-b][1,4]benzodiazepin-6-one; AKOS030210962; ZINC669678933; AX15836; AX 15836; AX-15836. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 2035509-96-5. Molecular formula: C32H40N8O5S. Mole weight: 648.78. |
| Axenomycin B Quick inquiry Where to buy |
Axenomycin B is produced by the strain of Streptomyces lisandri F. I. 2604. It has antifungal, nematode and trichomonas activities. Grades: Lab chemicals, Laboratory Reagents Grade. Molecular formula: C29H38O10. Mole weight: 546.60. |
| Axillaridine A Quick inquiry Where to buy |
Axillaridine A isolated from the herbs of Pachysandra axillaris, it is a potent natural cholinesterase inhibitor. Synonyms: N-[(5α,20S)-20-(Dimethylamino)-4-oxopregn-2-en-3-yl]benzamide. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 128255-16-3. Molecular formula: C30H42N2O2. Mole weight: 462.7. |
| Axillarin Quick inquiry Where to buy |
Axillarin is a natural compound isolated from the herbs of Tagetes mendocina. Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress. Axillarin shows xanthine oxidase inhibitory activity (IC50 :36.0 uM). Axillarin has antioxidant activity. Synonyms: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxychromen-4-one. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 5188-73-8. Molecular formula: C17H14O8. Mole weight: 346.28. |
| Axinysone A Quick inquiry Where to buy |
Axinysone A. Synonyms: (-)-Axinysone A. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1114491-57-4. Molecular formula: C15H22O2. Mole weight: 234.338. |
| Axinysone B Quick inquiry Where to buy |
Axinysone B is a metabolite of the mushroom Anthracophyllum sp. BCC18695. Synonyms: (-)-Axinysone B; 2H-Cyclopropa[a]naphthalen-2-one, 1,1a,4,5,6,7,7a,7b-octahydro-4-hydroxy-1,1,7,7a-tetramethyl-, (1aS,4R,7S,7aS,7bR)-. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1114491-60-9. Molecular formula: C15H22O2. Mole weight: 234.33. |
| Axitinib Quick inquiry Where to buy |
Axitinib (AG013736) is a tyrosine kinase inhibitor developed by Pfizer. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Synonyms: AG 013736; N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide; Inlyta. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 319460-85-0. Molecular formula: C22H18N4OS. Mole weight: 386.5. |
| Axitinib-[13C,d3] Quick inquiry Where to buy |
Axitinib-[13C,d3] is a labelled Axitinib. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Synonyms: [13C,2H3]-N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; (E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1261432-00-1. Molecular formula: C21[13C]H15D3N4OS. Mole weight: 390.48. |
| Axitinib-[d3] Quick inquiry Where to buy |
Axitinib-[d3] is the labelled analogue of Axitinib. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Synonyms: Axitinib D3; N-(Methyl-d3)-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; AG 013736-d3; Axitinib-d3 (N-methyl-d3). Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1126623-89-9. Molecular formula: C22H15D3N4OS. Mole weight: 389.49. |
| Axitinib Impurity 1 Quick inquiry Where to buy |
Axitinib Impurity 1. Synonyms: Axitinib Impurity c. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 885126-40-9. Molecular formula: C22H18N4OS. Mole weight: 386.48. |
| Axitinib Impurity 2 Quick inquiry Where to buy |
An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide). Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1428728-83-9. Molecular formula: C44H36N8O2S2. Mole weight: 772.96. |
| Axitinib Impurity 4 Quick inquiry Where to buy |
Axitinib Impurity 4. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1443118-73-7. Molecular formula: C22H20N4OS. Mole weight: 388.49. |
| Axitinib Impurity 6 Quick inquiry Where to buy |
Axitinib Impurity 6. Synonyms: Axitinib Impurity d. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1443118-72-6. Molecular formula: C29H25N5OS. Mole weight: 491.62. |
| Axitinib Impurity 8 Quick inquiry Where to buy |
Axitinib Impurity 8. Synonyms: 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide; BenzaMide, 2-(1H-indazol-6-ylthio)-N-Methyl-; Axitinib Impurity e. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 944835-85-2. Molecular formula: C15H13N3OS. Mole weight: 283.35. |
| Axitinib sulfone Quick inquiry Where to buy |
An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: Sulfonyl axitinib; (E)-N-methyl-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylsulfonyl)benzamide; N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1348536-59-3. Molecular formula: C22H18N4O3S. Mole weight: 418.47. |
| Axitinib sulfoxide Quick inquiry Where to buy |
A major metabolite of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide; Axitinib Impurity A. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1347304-18-0. Molecular formula: C22H18N4O2S. Mole weight: 402.48. |
| Axltide Quick inquiry Where to buy |
Axltide is based on mouse insulin receptor substrate 1 (amino acids 979-989). It is also a substrate for the kinases AXL, DDR2, MST1 and JAK2. Synonyms: Axl/Insulin Receptor Substrate Peptide; H-Lys-Lys-Ser-Arg-Gly-Asp-Tyr-Met-Thr-Met-Gln-Ile-Gly-OH; L-lysyl-L-lysyl-L-seryl-L-arginyl-glycyl-L-alpha-aspartyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-glutaminyl-L-isoleucyl-glycine. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 143364-95-8. Molecular formula: C63H107N19O20S2. Mole weight: 1514.77. |
| AY 9944 dihydrochloride Quick inquiry Where to buy |
on in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. . Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. |
| Ayanin Quick inquiry Where to buy |
Ayanin isolated from the rhizomes of Curcuma aromatica. Synonyms: QUERCETIN 3,7,4'-TRIMETHYL ETHER;AYANIN;2-(3-Hydroxy-4-methoxyphenyl)-3,7-dimethoxy-5-hydroxy-4H-1-benzopyran-4-one;3',5-Dihydroxy-3,4',7-trimethoxyflavone; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxychromen-4-one. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 572-32-7. Molecular formula: C18H16O7. Mole weight: 344.3. |
| AY-NH2 Quick inquiry Where to buy |
ets in vitro. It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. It induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips. It also inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. It increases paw thickness in a rat paw edema inflammation model in vivo. . Synonyms: PAR-4 Agonist Peptide, amide; L-Alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide; PAR-4-AP; Proteinase-activated Receptor 4 Activating Peptide. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 352017-71-1. Molecular formula: C34H48N8O7. Mole weight: 680.79. |
| AZ0108 Quick inquiry Where to buy |
AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S) -4- ( (3- (3- (1, 1-difluoroethyl) -6-methyl-5, 6, 7, 8-tetrahydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7-carbonyl) phenyl) difluoromethyl) phthalazin-1 (2H) -one; AZ0108; AZ-0108; AZ 0108. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. |
| AZ 10397767 Quick inquiry Where to buy |
nificantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. . Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88. |
| AZ 10417808 Quick inquiry Where to buy |
AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. |
| AZ 10606120 dihydrochloride Quick inquiry Where to buy |
of AZ 10606120, which is a potent and negative allosteric modulator of the human P2X7 receptor. Its KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively. It binds in a positive cooperative manner to sites and acts as a negative allosteric modulator. It is a key modulator of the PI3K/GSK3β/VEGF signaling network. It inhibits tumor growth and shows antiangiogenic effects in mice. . Synonyms: AZ10606120; AZ 10606120; AZ-10606120; N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide Dihydrochloride; 2- (1-Adamantyl) -N-[2-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]quinolin-5-yl]acetamide Dihydrochloride. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 607378-18-7. Molecular formula: C25H36N4O2Cl2. Mole weight: 495.48. |
| AZ11645373 Quick inquiry Where to buy |
AZ11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Synonyms: 3-[1-[[(3-nitro[1,1-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione; AZ 11645373; AZ-11645373; AZ11645373; UNII-XY4SZP4C72; GTPL4142. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 227088-94-0. Molecular formula: C24H21N3O5S. Mole weight: 463.51. |
| AZ11665362 Quick inquiry Where to buy |
AZ11665362 is a potent CRTH2 antagonist. It blocks the migration of eosinophils and basophils, and the rapid mobilization of eosinophils from bone marrow. It might be useful for the treatment of allergic diseases. Synonyms: AZ-11665362; AZ 11665362; AZ11665362; (2,5-Dimethyl-3-(8-methyl-4-quinolinyl)-1H-indol-1-yl)acetic acid. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 629645-40-5. Molecular formula: C22H20N2O2. Mole weight: 344.41. |
| AZ 12080282 dihydrochloride Quick inquiry Where to buy |
AZ 12080282 dihydrochloride is a potent Hh inhibitor with IC50 value <0.012 μM. It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency. Synonyms: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride. Grades: Laboratory chemicals, Lab Reagent Grade. Molecular formula: C23H20N4O2·2HCl. Mole weight: 457.35. |
| AZ 12216052 Quick inquiry Where to buy |
AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35. |
| AZ13705339 Quick inquiry Where to buy |
AZ13705339 is a potent and selective PAK1 inhibitor (IC50 = 0.33 nM). PAK1 is commonly overexpressed in breast tumors. Synonyms: AZ13705339; AZ 13705339; AZ-13705339; 2-[[N-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 2016806-57-6. Molecular formula: C33H36FN7O3S. Mole weight: 629.75. |
| AZ-1495 Quick inquiry Where to buy |
AZ-1495 is a novel inhibitor of interleukin-1 receptor-associated kinases (IRAKs), a component in the signal transduction pathways utilized by IL-1R, IL-18R and TLRs. Study showed that AZ-1495 exhibited a potent inhibitory effect on NF-kappaB receptor within 3 hours after intake. It is potentially used to treat CNS lymphoma. Synonyms: AZ-1495; AZ 1495; AZ1495. Grades: Laboratory chemicals, Lab Reagent Grade. |
| AZ1508 Quick inquiry Where to buy |
AZ1508 is a drug-linker conjugates for ADC for the treatment of breast and stomach cancer, and the drug is a tubulin inhibitor. Synonyms: AZ1508; AZ 1508; AZ-1508; MC-Lys-MMETA; (2S, 4R) -4-[[2-[ (1R, 3R) -1-acetyloxy-3-[[ (2S, 3S) -2-[[ (2R, 4R) -1, 4-dimethylpiperidine-2-carbonyl]amino]-3-methylpentanoyl]-ethylamino]-4-methylpentyl]-1, 3-thiazole-4-carbonyl]amino]-5-[4-[[ (2S) -6-amino-2-[6- (2, 5-dioxopyrrol-1-yl) hexanoylamino]hexanoyl]amino]phenyl]-2-methylpentanoic acid. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1817736-04-1. Molecular formula: C56H85N9O11S. Mole weight: 1092.39. |
| AZ191 Quick inquiry Where to buy |
AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Synonyms: AZ191; AZ 191; AZ-191. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1594092-37-1. Molecular formula: C24H27N7O. Mole weight: 429.52. |
| AZ20 Quick inquiry Where to buy |
In vitro, AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Synonyms: AZ20; AZ-20; AZ 20. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1233339-22-4. Molecular formula: C21H24N4O3S. Mole weight: 412.51. |
| AZ-2088 Quick inquiry Where to buy |
AZ-2088. Synonyms: AZ-2088; AZ 2088; AZ2088; heptyl-(2-hydroxy-2-methyl-5-propan-2-ylcyclohexyl)-dimethylazanium;bromide; AZ-2088; AZ 2088; AZ2088; dimethylheptyl(1-hydroxy-p-menth-2-yl)ammonium.Br. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 20091-61-6. Molecular formula: C19H40BrNO. Mole weight: 378.439. |
| AZ 23 Quick inquiry Where to buy |
AZ 23 is a potent and selective tyrosine kinase (Trk) inhibitor with the potential for therapeutic utility in neuroblastoma and multiple other cancer indications. Synonyms: AZ-23; AZ 23; AZ23; UNII-009OMI967N; 5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 915720-21-7. Molecular formula: C17H19ClFN7O. Mole weight: 391.83. |
| AZ304 Quick inquiry Where to buy |
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52. |
| AZ31 Quick inquiry Where to buy |
AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. |
| AZ 3146 Quick inquiry Where to buy |
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. |
| AZ32 Quick inquiry Where to buy |
with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. . Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grades: Laboratory chemicals, Lab Reagent Grade. Molecular formula: C20H16N4O. Mole weight: 328.37. |
| Az-33 Quick inquiry Where to buy |
Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Synonyms: Az-33; Az 33; Az33; {4-[4-({3-[(2-Methyl-1,3-Benzothiazol-6-Yl)amino]-3-Oxopropyl}amino)-4-Oxobutyl]benzyl} Propanedioic Acid; 88N; LDHA Inhibitor, 33; CHEMBL2059811; CHEMBL 2059811; CHEMBL-2059811. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.566. |
| AZ 3451 Quick inquiry Where to buy |
2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling. . Synonyms: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide; AZ-3451; AZ3451. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 2100284-59-9. Molecular formula: C30H27BrN4O3. Mole weight: 571.46. |
| AZ505 Quick inquiry Where to buy |
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ505; AZ 505; AZ-505. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1035227-43-0. Molecular formula: C29H38Cl2N4O4. Mole weight: 577.54. |
| AZ505 ditrifluoroacetate Quick inquiry Where to buy |
AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ505 ditrifluoroacetate; AZ 505 ditrifluoroacetate; AZ-505 ditrifluoroacetate. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1035227-44-1. Molecular formula: C33H40Cl2F6N4O8. Mole weight: 805.59. |
| AZ5104 Quick inquiry Where to buy |
AZ5104 is a potent EGFR inhibitor and a derivative of AZD 9291. AZ5104 exhibits reduced selectivity against wild-type EGFR but five-fold potentcy compared to AZD 9291. Synonyms: AZ-5104; AZ 5104; N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1421373-98-9. Molecular formula: C27H31N7O2. Mole weight: 485.592. |
| AZ 5704 Quick inquiry Where to buy |
AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM in an enzyme inhibition assay. It exhibits 600-fold selectivity for ATM over other kinases. AZ 5704 is also orally bioavailable. Synonyms: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide; AZ-5704; AZ5704. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1941214-06-7. Molecular formula: C23H23FN6O2. Mole weight: 434.47. |
| AZ6102 Quick inquiry Where to buy |
AZ6102 is a moderate oral bioavailable dual inhibitor of TNKS1/2 with excellent selectivity against other PARP family enzymes including PARP-1, PARP-2 and PARP-6. It also inhibits Wnt signaling in DLD-1 cells. IC50: TNKS2= 1 nM; TNKS1= 3 nM; Wnt signaling. Synonyms: 2-[4-[6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-oneAZ6102; AZ-6102; AZ 6102.AZ 6102|rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidi. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1645286-75-4. Molecular formula: C25H28N6O. Mole weight: 428.53. |
| AZ 628 Quick inquiry Where to buy |
AZ628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). It displays selectivity for Raf kinases over a panel of 150 other kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Synonyms: AZ628; AZ-628; AZ 628. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 878739-06-1. Molecular formula: C27H25N5O2. Mole weight: 451.52. |
| AZ7371 Quick inquiry Where to buy |
AZ7371 is a a novel non-covalent DprE1 inhibitor. Synonyms: AZ7371; AZ-7371; AZ 7371. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1494675-86-3. Molecular formula: C18H21N5O3. Mole weight: 355.40. |
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erary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 µM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. . Synonyms: AZ-82; AZ 82. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. |
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curring the aforementioned adverse effects. Whether AZ876 exerts additional protection in the heart remains to be explored. LXR activation with AZ876 attenuated this increase, and significantly reduced TAC-induced increases in heart weight, myocardial fibrosis, and cardiac dysfunction without affecting blood pressure. AZ876 was also 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human. . Synonyms: AZ 876; AZ-876; AZ12260493; AZ 12260493; AZ-12260493. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 898800-26-5. Molecular formula: C24H29N3O3S. Mole weight: 439.57. |
| AZ-960 Quick inquiry Where to buy |
AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM. Synonyms: AZ 960; 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 905586-69-8. Molecular formula: C18H16F2N6. Mole weight: 354.365. |
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~4-fold increase in efficiency with OSKM and promotes full reprogramming. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 66323-44-2. Molecular formula: C10H12N8O2. Mole weight: 276.26. |
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Azacetidine Monoacetate is an impurity of 5-Azacytidine, an antiproliferative/cytotoxic agent for leukemia therapy. Synonyms: ((2R,3S,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl acetate; 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1174733-90-4. Molecular formula: C10H14N4O6. Mole weight: 286.24. |
| Azacitidine-[15N4] Quick inquiry Where to buy |
h as acute myeloid leukaemia (AML) or chronic myelomonocytic leukaemia (CMML). It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~0.4 μM for inhibiting proliferation of various cancer cell lines). It can also act as a demethylating agent by inhibiting DNA methyltransferase. . Grades: Lab chemicals, Laboratory Reagents Grade. Molecular formula: C8H12[15N]4O5. Mole weight: 248.18. |
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Azacyclonol, also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals. Synonyms: MER 17, MDL 4829; MER17, MDL4829; MER-17, MDL-4829. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 115-46-8. Molecular formula: C18H21NO. Mole weight: 267.37. |
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as acute myeloid leukaemia (AML) or chronic myelomonocytic leukaemia (CMML). It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines). It can also act as a demethylating agent by inhibiting DNA methyltransferase. . Synonyms: 1-(beta-D-Ribofuranosyl)-5-azacytosine; 5-Azacytidine; Vidaza; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; NSC 102816; U18496; U-18496; U 18496; 5AC; 5AZC; 5-azacytidine; ladakamycin; Mylosar. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 320-67-2. Molecular formula: C8H12N4O5. Mole weight: 244.20. |
| Azacytidine-[13C5] Quick inquiry Where to buy |
as acute myeloid leukaemia (AML) or chronic myelomonocytic leukaemia (CMML). It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines). It can also act as a demethylating agent by inhibiting DNA methyltransferase. . Synonyms: 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one 13C5. Grades: Laboratory chemicals, Lab Reagent Grade. Molecular formula: C8H12N4O5. Mole weight: 249.17. |
| Azafenidin-[13C6] Quick inquiry Where to buy |
Azafenidin-[13C6] is a stable isotope compound of Azafenidin. Azafenidin is a weed controlling herbicide used in various crops. Grades: Laboratory chemicals, Lab Reagent Grade. Molecular formula: C9[13C]6H13Cl2N3O2. Mole weight: 344.14. |
| Azaleatin (RG) Quick inquiry Where to buy |
Azaleatin is an O-methylated flavonol, a type of flavonoid. It was first isolated from the flowers of Rhododendron mucronatum in 1956 and has since been recorded in forty-four other Rhododendron species, in Plumbago capensis, in Ceratostigma willmottiana and in Carya pecan. It has been also been found in the leaves of Eucryphia. It is the 3-O-α-L-rhamnoside of azaleatin. Synonyms: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-5-methoxy-4H-1-benzopyran-4-one; 3,3',4',7-Tetrahydroxy-5-methoxyflavone; 5-O-Methyl quercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-5-methoxychromen-4-one; Quercetin 5-Methyl Ether; 2-(3,4-Dihydroxycyclohexa-2,4-dien-1-yl)-3,7-dihydroxy-5-methoxy-4H-chromen-4-one. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 529-51-1. Molecular formula: C16H12O7. |
| Azamethiphos-[d6] Quick inquiry Where to buy |
Azamethiphos-[d6]. Synonyms: Azamethiphos D6; S-[(6-Chloro-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)methyl] O,O-Dimethyl-d6 Ester Phosphorothioic Acid; Azametiphos-d6; CGA 18809-d6; Ciba-Geigy 18809-d6; Salmosan-d6; Snip-d6. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1189894-02-7. Molecular formula: C9H4D6ClN2O5PS. Mole weight: 330.71. |
| Azamulin Quick inquiry Where to buy |
Azamulin is an azole derivative of pleuromutilin. Azamulin is a highly selective inhibitor of cytochrome P450 3A4 (CYP3A4). Synonyms: Azamulinum. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 76530-44-4. Molecular formula: C24H36N4O4S. Mole weight: 476.63. |
| Azapentacene Quick inquiry Where to buy |
Azapentacene is used in ophthalmologic eye lotions containing polymers with side-chains of phosphorylcholine analogs. Synonyms: 5,12-Dihydro-quinoxalino[2,3-b]phenazine sulfonate sodium salt; Sodium 5,12-dihydroazapentacene disulfonate; Phacolysine Sodium Salt ; Phacolin; Quinax. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 3863-80-7. Molecular formula: C18H10N4O6S2Na2. Mole weight: 488.41. |
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Azaperol acts as a dopamine antagonist and also has antihistaminic and anticholinergic properties. Azaperol is commonly used as a butyrophenone neuroleptic drug in veterinary medicine. Synonyms: 1-(4-Fluorophenyl)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-ol. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 2804-5-9. Molecular formula: C19H24FN3O. Mole weight: 329.419. |
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Azaperol-[d4] is a labelled Azaperol, which is a metabolite of azaperone. Synonyms: 1-(4-Fluorophenyl-D4)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-ol. Grades: Laboratory chemicals, Lab Reagent Grade. Molecular formula: C19H20D4FN3O. Mole weight: 333.44. |
| Azaperone Quick inquiry Where to buy |
Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Synonyms: NSC 170976; NSC170976; NSC-170976. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 1649-18-9. Molecular formula: C19H22FN3O. Mole weight: 327.4. |
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Azaperone-[d4] is the labelled analogue of Azaperone, which is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects. It is mainly used as a tranquilizer in veterinary medicine. Synonyms: Azaperone-D4; 1-(4-Fluorophenyl-D4)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-one; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone-d4; 4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone-d4; Fluoperidol-d4; NSC 170976-d4; Stresnil-d4; Suicalm-d4. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 1173021-72-1. Molecular formula: C19H18D4FN3O. Mole weight: 331.42. |
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An antidepressant having effects on the autonomic nervous system; the drug is especially effective for mild and moderate depressions and a combination of Azaphen and Thymol is applicable for severa depressions. Azaphen improves sleep too. Synonyms: Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride. Grades: Laboratory chemicals, Lab Reagent Grade. CAS No. 24853-80-3. Molecular formula: C16H21Cl2N5O. Mole weight: 370.28. |
| Azaphen dihydrochloride monohydrate Quick inquiry Where to buy |
Azaphen dihydrochloride monohydrate is a potent inhibitor of the reuptake of serotonin. It is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression. Synonyms: Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate. Grades: Lab chemicals, Laboratory Reagents Grade. CAS No. 63302-99-8. Molecular formula: C16H23Cl2N5O2. Mole weight: 388.29. |
