BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
Boc-S-trityl-L-penicillamine is a derivative of D-Penicillamine, which is a penicillin metabolite used in the treatment of Wilson's disease, Cystinuria, Scleroderma and arsenic poisoning. Synonyms: Boc-L-Pen(Trt)-OH; Boc-β,β-dimethyl-L-Cys(Trt)-OH; Boc-Pen(Trt)-OH; N-[(1,1-Dimethylethoxy)carbonyl]-3-[(triphenylmethyl)thio]-L-valine; (R)-2-((tert-Butoxycarbonyl)amino)-3-methyl-3-(tritylthio)butanoic acid; N-alpha-t-Butoxycarbonyl-S-trityl-L-penicillamine; N-(tert-Butoxycarbonyl)-3-[(triphenylmethyl)sulfanyl]-L-valine; N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-(tritylsulfanyl)valine. Grades: ≥95%. CAS No. 135592-13-1. Molecular formula: C29H33NO4S. Mole weight: 491.64.
An analog of Boc-(±)-trans-4-(4-bromophenyl)pyrrolidine-3-carboxylic acid, which is used to prepare substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors. Synonyms: (±)-trans-1-(t-Butoxycarbonyl)-4-(3-nitrophenyl)pyrrolidine-3-carboxylic acid; (3R,4S)-1-(tert-Butoxycarbonyl)-4-(3-nitrophenyl)pyrrolidine-3-carboxylic Acid. CAS No. 959577-50-5. Molecular formula: C16H20N2O6. Mole weight: 336.34.
An intermediate used in the asymmetric synthesis of isoxazoline and hydroxyketomethylene dipeptide isosteres. Synonyms: Boc-L-valine methyl ester; L-Boc valine methyl ester; (S)-methyl 2-(tert-butoxycarbonylamino)-3-methylbutanoate; Boc-L-Val-Ome; Boc L Val Ome; Boc Val Ome. Grades: 95%. CAS No. 58561-04-9. Molecular formula: C11H21NO4. Mole weight: 231.29.
CADY is a secondary amphiphilic peptide that has been shown to efficiently deliver short nucleic acids, especially siRNA, but cannot deliver any peptides, even short negatively charged peptides. Synonyms: Ac-Gly-Leu-Trp-Arg-Ala-Leu-Trp-Arg-Leu-Leu-Arg-Ser-Leu-Trp-Arg-Leu-Leu-Trp-Arg-Ala-cysteamide. Grades: >98%. Molecular formula: C132H205N41O26S. Mole weight: 2814.41.
It is a cell penetrating peptide. Synonyms: H-Lys-Leu-Thr-Arg-Ala-Gln-Arg-Arg-Ala-Ala-Ala-Arg-Lys-Asn-Lys-Arg-Asn-Thr-Arg-OH; L-lysyl-L-leucyl-L-threonyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-asparagyl-L-lysyl-L-arginyl-L-asparagyl-L-threonyl-L-arginine. Grades: ≥95%. Molecular formula: C93H175N43O25. Mole weight: 2295.70.
Cell Penetrating ARF Peptide (26-44)
It is a cell penetrating peptide corresponding to amino acids 26 to 44 of the ARF tumor suppressor protein fused to nine D-Arginine (D-Arg) residues. Synonyms: H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Lys-Phe-Val-Arg-Ser-Arg-Arg-Pro-Arg-Thr-Ala-Ser-Cys-Ala-Leu-Ala-Phe-Val-Asn-OH; D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-L-lysyl-L-phenylalanyl-L-valyl-L-arginyl-L-seryl-L-arginyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-alanyl-L-seryl-L-cysteinyl-L-alanyl-L-leucyl-L-alanyl-L-phenylalanyl-L-valyl-L-asparagine. Grades: ≥95%. Molecular formula: C149H267N69O33S. Mole weight: 3585.29.
Cephalexin Impurity A (D-2-Phenylglycine)
Cas No. 875-74-1.
Cereolysin
Cerebrolysin is a multimodal neuropeptide drug used for the treatment of ischemic and hemorrhagic stroke, brain trauma, dementia and cognitive impairment. It can improve the brain's self-repair ability by stimulating nerve recovery. Synonyms: HE383245. CAS No. 72270-31-6. Molecular formula: C59H94N16O19S. Mole weight: 1363.54.
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)
It is a peptide extracted from the rabies virus glycoprotein (RVG). Since neurotropic viruses infect brain cells across the blood-brain barrier, the same strategy could be used to enter the central nervous system and deliver siRNA to the brain. To enable siRNA to bind, this chimeric peptide is synthesized by adding a non-Amer arginine residue to the carboxyl terminus of RVG. The RVG-9R peptide binds and transduces siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. Rvg-9r provides a safe, non-invasive method for delivering siRNA and other therapeutic molecules across the blood-brain barrier. Synonyms: H-Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH. Grades: >95%. Molecular formula: C201H334N82O55S2. Mole weight: 4843.51.
Chloroacetyl-DL-2-amino-N-butyric acid
Synonyms: ClAc-DL-Abu-OH; ClAc DL Abu OH. Grades: ≥ 98%. CAS No. 67183-18-0. Molecular formula: C6H10NO3Cl. Mole weight: 179.60.
cis-L-4-Hydroxyproline is an essential amino acid widely used in the biomedical industry. It plays a crucial role in collagen synthesis, making it highly valuable for studying connective tissue disorders such as Ehlers-Danlos syndrome and osteoporosis. Synonyms: L-Proline, 4-hydroxy-, (4S)-; (4S)-4-Hydroxy-L-proline; L-Proline, 4-hydroxy-, cis-; Proline, 4-allo-hydroxy-; Proline, 4-allo-hydroxy-, L-; (2S,4S)-4-Hydroxyproline; (S)-allo-Hydroxyproline; 4(S)-Hydroxy-2(S)-pyrrolidinecarboxylic acid; 4-cis-Hydroxy-L-proline; L-allo-4-Hydroxyproline; L-allo-Hydroxyproline; L-Allohydroxyproline; L-cis-4-Hydroxyproline; L-Proline, allo-hydroxy-; allo-4-Hydroxyproline; allo-L-Hydroxyproline; allo-Hydroxy-L-proline; cis-4-Hydroxy-L-proline; cis-4-Hydroxyproline; cis-Hydroxyproline; H-Cis-Hyp-OH; cis-L-Hyp-OH; NSC 206274. Grades: ≥95%. CAS No. 618-27-9. Molecular formula: C5H9NO3. Mole weight: 131.13.
Cispentacin is produced by the strain of Streptomyces setonii and Bacillus cereus. It has anti-candida and other fungi activity, and has no toxicity at 1g/kg. Synonyms: 2-aminocyclopentane-1-carboxylic acid; cis-2-Ac5c; cispentacin, (cis)-isomer. Grades: ≥ 95%. CAS No. 122672-46-2. Molecular formula: C6H11NO2. Mole weight: 129.16.
Cycloleucine is a competitive inhibitor of glycine modulatory site of N-methyl-D-aspartate (NMDA) receptor, with immunosuppressive, antineoplastic and cytostatic activities. It competitively inhibits methionine adenosyltransferase, thereby inhibiting S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production. Synonyms: 1-Aminocyclopentanecarboxylic acid; 1-Amino-1-cyclopentanecarboxylic acid; 1-Amino-1-carboxycyclopentane; NSC 1026; NSC 112194; NSC 112195; NSC 112197; ACPC. Grades: ≥98%. CAS No. 52-52-8. Molecular formula: C6H11NO2. Mole weight: 129.16.
Cycloserine Impurity 1
D-Serine is a proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. It is a inhibitor of serine palmitoyltransferase. It is also a neuromodulator. Synonyms: D-Serine; (R)-2-Amino-3-hydroxypropanoic Acid; (R)-2-Amino-3-hydroxypropanoic Acid; (R)-Serine; NSC 77689. Grades: ≥ 99% (Titration: anhydrous basis). CAS No. 312-84-5. Molecular formula: C3H7NO3. Mole weight: 105.09.
Cycloserine Impurity 2
Cycloserine Impurity 2 is a derivative of Cycloserine, renowned for its remarkable efficacy in treating tuberculosand sundry bacterial afflictions. Synonyms: D-Serine Methyl Ester Hydrochloride; (R)-2-Amino-3-hydroxypropionic Acid Methyl Ester Hydrochloride; (R)-Methyl 2-Amino-3-hydroxypropanoate Hydrochloride; Methyl D-Serinate Hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 5874-57-7. Molecular formula: C4H10ClNO3. Mole weight: 155.58.
[Cys58]105Y, α1-antitrypsin (358-374)
It is a synthetic peptide based on the sequence corresponding to residues 359 to 374 of α1-antitrypsin. C105Y can penetrate cell membrane rapidly, enter the cytoplasm, and localize to the nucleus and nucleolus of live culture cells. C105Y peptide enters the nucleolus very rapidly in an energy-dependent manner. Membrane transport and nuclear localization are energy-independent. It enhances gene expression in DNA nanoparticles. Synonyms: Cys-Ser-Ile-Pro-Pro-Glu-Val-Lys-Phe-Asn-Lys-Pro-Phe-Val-Tyr-Leu-Ile. Grades: >98%. Molecular formula: C97H148N20O23S. Mole weight: 1994.43.
Cys(Npys)-(Arg)9
It is a peptide composed of 9 arginine residues synthesized from an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl protective cysteine. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutic agents such as siRNA in the reducing environment within the cell. Synonyms: H-Cys(Nyps)-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2; S-(3-nitropyridin-2-yl)sulfanyl-L-cysteinyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-argininamide. Grades: ≥95%. CAS No. 1417221-06-7. Molecular formula: C62H118N40O12S2. Mole weight: 1679.99.
Cys(Npys)-(D-Arg)9
It is a peptide consisting of 9 D-arginine residues and one activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This modification has been used to make the peptide suitable for conjugation and cell permeability studies as a carrier peptide. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Synonyms: H-Cys(Npys)-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2; S-(3-nitropyridin-2-yl)sulfanyl-D-cysteinyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide. Grades: ≥95%. Molecular formula: C62H118N40O12S2. Mole weight: 1679.99.
Cys(Npys)-TAT (47-57)
Cys(Npys)-TAT (47-57), corresponding to the protein transduction domain of TAT protein, is synthesized from the activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group that activates cysteine S and reacts rapidly when thiol groups are introduced. This modification has been used to make the peptide suitable for conjugation studies as a cell-penetrating and carrier peptide. Synonyms: Cys(Npys)-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2. Grades: ≥95%. Molecular formula: C72H126N36O16S2. Mole weight: 1816.13.
Cys(Npys)-TAT (47-57), FAM-labeled
It corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. It is synthesized with C(Npys) at the N-terminus for applications requiring specific conjugation reactions and has a fluorophore labeled with FAM having Abs/Em=494/518 nm. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies. Synonyms: Cys(Npys)-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys(FAM)-NH2. Grades: ≥95%. Molecular formula: C99H148N38O23S2. Mole weight: 2302.61.
Cys-TAT (48-60)
It is a TAT (Transactivated-transcripiton) peptide derived from the HIV TAT protein, which has the ability to transduce peptides or proteins into various cells. Synonyms: H-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-NH2. Grades: >95%. Molecular formula: C73H137N37O16S. Mole weight: 1821.20.
D-2,3-Diaminopropionic acid hydrochloride
Synonyms: D-Dap-OH HCl; (R)-2,3-Diaminopropionic acid hydrochloride; D Dap OH HCl. Grades: ≥ 99% (Assay by titration). CAS No. 6018-56-0. Molecular formula: C3H8N2O2·HCl. Mole weight: 140.57.
D-2,4-Diaminobutyric acid dihydrochloride
Synonyms: D-Dab-OH 2HCl; (R)-2,4-Diaminobutyric acid dihydrochloride; D Dab OH 2HCl. Grades: 98%. CAS No. 26908-94-1. Molecular formula: C4H10N2O2·2HCl. Mole weight: 191.14.
Alanine (abbreviated as Ala or A) is a non-polar α-amino acid, with the formula CH3CH(NH2)COOH. The L-isomer (left-handed) of alanine is one of the 20 amino acids encoded by the human genetic code. Its genetic codons are GCU, GCC, GCA, and GCG. L-Alanine is second only to leucine in rate of occurrence, accounting for 7.8% of the primary structure in a sample of 1,150 proteins.The right-handed form, D-Alanine occurs in bacterial cell walls and in some peptide antibiotics. Uses: Amino acid. Synonyms: D-Ala-OH; D-alpha-Aminopropionic acid. Grades: >98%. CAS No. 338-69-2. Molecular formula: C3H7NO2. Mole weight: 89.09.