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UNC1999
UNC1999. Group: Biochemicals. Alternative Names: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-Indazole-4-carboxamide. Grades: Highly Purified. CAS No. 1431612-23-5. Pack Sizes: 5mg. Molecular Formula: C33H43N7O2, Molecular Weight: 569.74. US Biological Life Sciences.
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Undecane -1, 11-diyl-bismethane thiosulfonate
Undecane -1, 11-diyl-bismethane thiosulfonate. Group: Biochemicals. Alternative Names: MTS-11-MTS. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C13H28O4S4, Molecular Weight: 376.62. US Biological Life Sciences.
URB 937. Group: Biochemicals. Alternative Names: N-Cyclohexyl-carbamic Acid 3'-(Aminocarbonyl)-6-hydroxy[1,1'-biphenyl]-3-yl Ester. Grades: Highly Purified. CAS No. 1357160-72-5. Pack Sizes: 10mg. Molecular Formula: C20H22N2O4, Molecular Weight: 354.4. US Biological Life Sciences.
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Urea-15N2
Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic. Group: Biochemicals. Alternative Names: Aquacare-15N2; Aquadrate-15N2; B-I-K-15N2; Basodexan-15N2; Benural 70-15N2; Carbamide-15N2; Carbamimidic Acid-15N2; Carbonyl Diamide-15N2; Carmol 40-15N2. Grades: Highly Purified. CAS No. 2067-80-3. Pack Sizes: 10mg, 250mg, 1g. US Biological Life Sciences.
Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant. Group: Biochemicals. Alternative Names: 7,9-Dihydro-1H-Purine-2,6,8(3H)-trione; 1H-Purine-2,6,8-triol; 2,6,8-Trihydroxypurine; 2,6,8-Trioxopurine; 2,6,8-Trioxypurine; Lithic Acid; NSC 3975; Purine-2,6,8(1H,3H,9H)-trione. Grades: Purified. CAS No. 1198-77-2. Pack Sizes: 5g, 25g. US Biological Life Sciences.
Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant. Group: Biochemicals. Alternative Names: 7,9-Dihydro-1H-Purine-2,6,8(3H)-trione; 1H-Purine-2,6,8-triol; 2,6,8-Trihydroxypurine; 2,6,8-Trioxopurine; 2,6,8-Trioxypurine; Lithic Acid; NSC 3975; Purine-2,6,8(1H,3H,9H)-trione. Grades: Purified. CAS No. 1198-77-2. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences.
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Uridine[1'-D]
Uridine[1'-D]. Group: Biochemicals. Alternative Names: 1- β-D-Ribofuranosyluracil-[1'-D]; β-Uridine-[1'-D]; 1- β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione-[1'-D]; 1- β-D-Ribofuranosyluracil-[1'-D]; NSC 20256-[1'-D]. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C9DH11N2O6, Molecular Weight: 245.21. US Biological Life Sciences.
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Uridine-[5',5'-D2]
Uridine-[5',5'-D2]. Group: Biochemicals. Alternative Names: 1- β -D-Ribofuranosyluracil [5', 5'-D2]; β-Uridine[5',5'-D2]; 1- β -D-Ribofuranosyluracil [5', 5'-D2]; 1- β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione[5',5'-D2]; NSC 20256[5',5'-D2]; β-Uridine[5',5'-D2]. Grades: Highly Purified. CAS No. 82740-98-5. Pack Sizes: 1mg. Molecular Formula: C9D2H10N2O6, Molecular Weight: 246.21. US Biological Life Sciences.
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Uridine Diphosphate-α-D-[UL-13C6]galactose Disodium Salt
Uridine Diphosphate-α-D-[UL-13C6]galactose Disodium Salt. Group: Biochemicals. Alternative Names: UDP-α-D-[UL-13C6]galactose Disodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C913C6H22N2Na2O17P2, Molecular Weight: 616.22. US Biological Life Sciences.
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Ursodeoxycholic Acid Acyl- β-D-glucuronide, >85%
A metabolite of Ursodeoxycholic acid. Contains products of acyl migration which were not individually quantified. Group: Biochemicals. Alternative Names: 1-[(3α,5 β,7 β)-3,7-Dhydroxycholan-24-oate- β-D-glucopyranuronic Acid. Grades: Highly Purified. CAS No. 208038-28-2. Pack Sizes: 1mg. US Biological Life Sciences.
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Ursolic Acid-d3
Ursolic Acid-d3 is labelled Ursolic Acid(U850100) which is a Triterpene acid used in cosmetics. It also has STAT3 pathway inhibiting properties. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C30H45D3O3, Molecular Weight: 459.72. US Biological Life Sciences.
A cell-permeable pyrrolylpyrrolidinyl-ethanone compound that directly targets proteasome-associated DUB (deubiquitinating enzyme) USP14 and acts as a potent, active-site-directed and reversible inhibitor of hUSP14 deubiquitinating catalytic activity (IC50=4.7uM for Ub-AMC hydrolysis) with excellent selectivity over proteasome-free USP14 and 8-other hDUBs including IsoT (IC50=100uM), UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2 and USP7 (IC50>700uM). Shown to enhance proteolysis in cells and induce degradation of misfolded toxic proteins like tau, TDP-43 and GFAP (glial fibrillary acidic protein) in coexpressed-wtMEFs at 50uM and offer protection against oxidative stress-induced cytotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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Vadimezan
Vadimezan. Group: Biochemicals. Alternative Names: 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic Acid; 5,6-Dimethyl-9-oxo-9H-xanthen-4-ylacetic Acid; 5,6-Dimethylxanthenone-4-acetic Acid; AS 1404; ASA 404; DMXAA; NSC 640488; 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic Acid. Grades: Highly Purified. CAS No. 117570-53-3. Pack Sizes: 10mg. Molecular Formula: C17H14O4, Molecular Weight: 282.29. US Biological Life Sciences.
Valacyclovir is a prodrug of Acyclovir with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain. Group: Biochemicals. Grades: Highly Purified. CAS No. 124832-27-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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(-)-Valerenic Acid
(-)-Valerenic Acid. Group: Biochemicals. Alternative Names: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic Acid; [4S-[4α(E),7 β,7aα]]-3-(2,4,5,6,7,7a-Hexahydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-2-propenoic Acid; 2,4,5,6,7,7a-Hexahydro-α,3,7-trimethylindene-4-acrylic Acid; Valerenic Acid. Grades: Highly Purified. CAS No. 3569-10-6. Pack Sizes: 1mg. Molecular Formula: C15H22O2, Molecular Weight: 234.33. US Biological Life Sciences.
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Valeric Anhydride
Valeric Anhydride is used in the synthesis of non-imadazole histamine H3-antagonists. Also used in the preparation of millepachine derivatives as a new class of tubulin polymerization inhibitors. Group: Biochemicals. Alternative Names: Pentanoic Acid 1,1'-AnhydridePentanoic Acid Anhydride; Valeric Anhydride; Pentanoic Anhydride; Valeric Acid Anhydride; Valeryl Anhydride; n-Valeric Anhydride. Grades: Highly Purified. CAS No. 2082-59-9. Pack Sizes: 10ml. US Biological Life Sciences.
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Valeryl Chloride
Valeryl Chloride is used in the preparation of potent inhibitors of secretory phospholipase A2. Also used in the synthesis of small-molecule inhibitors of protein geranyl geranyl transferase Type I. Group: Biochemicals. Grades: Highly Purified. CAS No. 638-29-9. Pack Sizes: 10g, 25g, 50g. Molecular Formula: C?H?ClO, Molecular Weight: 120.58. US Biological Life Sciences.
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Valsartan Methyl Ester
Valsartan Methyl Ester. Group: Biochemicals. Alternative Names: N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-Valine Methyl Ester; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-Valine Methyl Ester; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine Methyl Ester. Grades: Highly Purified. CAS No. 137863-17-3. Pack Sizes: 50mg. Molecular Formula: C25H31N5O3, Molecular Weight: 449.55. US Biological Life Sciences.
Valsartan n-Propyl Impurity (V095770) derivative. Group: Biochemicals. Alternative Names: N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine Phenylmethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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Vandetanib N-Oxide
Vandetanib N-Oxide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C22H24BrFN4O3, Molecular Weight: 491.35. US Biological Life Sciences.
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Vanillyl Butyl Ether
Vanillyl butyl ether is a compound hypothesized to have warming and vasodilation mechanisms when applied on the skin as a cream. Group: Biochemicals. Grades: Highly Purified. CAS No. 82654-98-6. Pack Sizes: 5g, 25g. Molecular Formula: C12H18O3. US Biological Life Sciences.
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Vanillylmethanol
Vanillylmethanol. Group: Biochemicals. Alternative Names: 2-(3-Methoxy-4-hydroxyphenyl)ethanol; 2-(4-Hydroxy-3-methoxyphenyl)ethanol; 3-Methoxy-4-hydroxyphenethanol; 3-Methoxy-4-hydroxyphenethyl Alcohol; 4-(2-Hydroxyethyl)-2-methoxyphenol; 4-(2-Hydroxyethyl)guaiacol; 4-Hydroxy-3-methoxyphenethyl Alcohol; 4-Hydroxy-3-methoxyphenylethanol; Ba 2772; Homovanillic Alcohol; Homovanillyl Alcohol. Grades: Highly Purified. CAS No. 2380-78-1. Pack Sizes: 100mg. US Biological Life Sciences.
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Vapreotide
Vapreotide. Group: Biochemicals. Alternative Names: D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-?Tryptophanamide Cyclic (2?7)-disulfide1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane cyclic peptide deriv.; BMY 41606; Octastatin; RC 160; RC 160 (protein). Grades: Highly Purified. CAS No. 103222-11-3. Pack Sizes: 1mg. Molecular Formula: C57H70N12O9S2, Molecular Weight: 1131.36999999999. US Biological Life Sciences.
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Vapreotide Acetate
Vapreotide is a synthetic somatostatin (S676750) analog predominately used for the treatment of acute variceal bleeding. Group: Biochemicals. Alternative Names: D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-Tryptophanamide Cyclic (2?7)-disulfide1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane, Cyclic Peptide Deriv.; 16: PN: US20020042374 PAGE: 10 Claimed Protein; 20: PN: US6268342 SEQID: 23 Claimed Protein; 3: PN: EP1118336 SEQID: 3 Claimed Protein; BMY 41606; Octastatin; RC 160; RC 160 (protein). Grades: Highly Purified. CAS No. 116430-60-5. Pack Sizes: 5mg. US Biological Life Sciences.
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Varenicline Carbamoyl β-D-Glucuronide-d4
Varenicline Carbamoyl β-D-Glucuronide-d4. Group: Biochemicals. Alternative Names: 1-(6,7,9,10-Tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepin-8-carboxylate). Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H16D4N3O8. US Biological Life Sciences.
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(±)-Vasicine
(±)-Vasicine. Group: Biochemicals. Alternative Names: 1,2,3,9-Tetrahydro-pyrrolo[2,1-b]quinazolin-3-ol; (±)-Linarine; (±)-Peganine;DL-Vasicine; dl-Peganine; dl-Vasicine. Grades: Highly Purified. CAS No. 6159-56-4. Pack Sizes: 10mg. Molecular Formula: C11H12N2O, Molecular Weight: 188.23. US Biological Life Sciences.
Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide. Group: Biochemicals. Grades: Highly Purified. CAS No. 40077-57-4. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.
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Vat Orange 1
Vat Orange 1. Group: Biochemicals. Alternative Names: Dibromodibenzochrysene-7,14-dione; Ahcovat Golden Yellow RK; Benzadone Gold Yellow RK; C.I. 59105; C.I. Pigment Orange 77; C.I. Vat Orange 23; Carbanthrene Golden Yellow RK; Cibanone Golden Yellow FRK; Cibanone Golden Yellow RK; Helanthrene Yellow RK; Hostavat Golden Yellow RK; Indanthren Golden Yellow RK; Indanthrene Golden Orange BBG; Indanthrene Golden Yellow RK; Mikethren Gold Yellow RK; Nihonthrene Golden Yellow RK; Nyanthrene Golden Yellow RK; Palanthrene Golden Yellow RK; Paradone Golden Yellow RK; Pigment Orange 77; Ponsol Golden Orange 2BG; Romantrene Golden Yellow FRK; Sandothrene Golden Yellow NRK; Solanthrene Brilliant Yellow R; Symuler Fast Red NRK; Threne gold yellow RK; Tinon Golden Yellow RK; Vat Golden Yellow KKh; Vat Golden Yellow KKh 10; Vat Golden Yellow KKhP; Vat Golden Yellow RK. Grades: Highly Purified. CAS No. 1324-11-4. Pack Sizes: 100mg. Molecular Formula: C24H10Br2O2, Molecular Weight: 490.14. US Biological Life Sciences.
A cell-permeable quinazoline that acts as a potent, ATP-binding site-targeting, VEGFR2-selective inhibitor (IC50=32nM), while exhibiting much reduced or little activity against 16 other kinases. An effective antiangiogenesis agent (98% inhibition of HUVEC tube formation at 10uM; 80% inhibition of zebrafish embryos intersegmental vessel growth at 2.5uM) that significantly suppresses SW620- and HepG2-derived tumor growth in mice (by 72% and 63%, respectively, in 18 days; 100mg/kg/day; i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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Verruculogen (NA 209A, TR 1)
Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat. Group: Biochemicals. Alternative Names: (5R, 10S, 10aR) -1, 10, 10a, 14, 14aS, 15bS-hexahydro-10, 10a-dihydroxy-7-methoxy-2, 2-dimethyl-5- (2-methyl-1-propen-1-yl) -5H, 12H-3, 4-dioxa-5a, 11a, 15a-triazacyclooct [lm]indeno [5, 6-b]fluorene-11, 15 (2H, 13H) -dione. Grades: Highly Purified. CAS No. 12771-72-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H33N3O7. US Biological Life Sciences.
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Verteporfin
Verteporfin. Group: Biochemicals. Alternative Names: CL 318952; Visudyne; (4R,4aS)-rel-24H,26H-Benzo[b]porphine-9,13-dipropanoic acid, 18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-monomethyl Ester. Grades: Highly Purified. CAS No. 129497-78-5. Pack Sizes: 10mg. Molecular Formula: C41H44N4O9, Molecular Weight: 736.81. US Biological Life Sciences.
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Vidarabine Monohydrate
Vidarabine Monohydrate. Group: Biochemicals. Alternative Names: 9- β-D-Arabinofuranosyl-9H-purin-6-amine Hydrate (1:1); 9- β -D-Arabinofuranosyl adenine Monohydrate; Adenine Arabinofuranoside Hydrate. Grades: Highly Purified. CAS No. 24356-66-9. Pack Sizes: 250mg. Molecular Formula: C10H15N5O5, Molecular Weight: 285.26. US Biological Life Sciences.
A selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9mM). Group: Biochemicals. Grades: Highly Purified. CAS No. 68506-86-5. Pack Sizes: 10mg. US Biological Life Sciences.
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Vilazodone-d4.
Vilazodone-d4. Group: Biochemicals. Alternative Names: 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-(piperazinyl-d8)]-2-benzofurancarboxamide-d4; EMD 515259-d4. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C26H23D4N5O2, Molecular Weight: 445.55. US Biological Life Sciences.
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Vildagliptin ( (S) -1-[N- (3-hydroxy-1-adamantyl) glycyl]pyrrolidine-2-carbonitrile)
An antidiabetic agent. A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that breaks down Glucagon-like peptide 1 (GLP-1). By delaying the degradation of GLP-1, vildagliptin extends the action of insulin while also suppressing the release of glucagon. This leads to a reduction in elevated blood glucose levels (hyperglycemia), which is a characteristic feature of type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 274901-16-5. Pack Sizes: 10mg. US Biological Life Sciences.
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Vincristine-d6 Sulfate
Vincristine-d6 Sulfate. Group: Biochemicals. Alternative Names: 22-Oxovincaleukoblastine-d6 Sulfate. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
Violanthrone 79. Group: Biochemicals. Alternative Names: 16, 17-Bis (octyloxy) anthra [9, 1, 2-cde]benzo [rst]pentaphene-5, 10-dione. Grades: Highly Purified. CAS No. 85652-50-2. Pack Sizes: 100mg. Molecular Formula: C50H48O4, Molecular Weight: 712.91. US Biological Life Sciences.
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Viomellein (BRN4630536)
Genotoxic mycotoxin. Antibacterial (Gram-positive) and insecticidal. Group: Biochemicals. Grades: Highly Purified. CAS No. 55625-78-0. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.
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Vismodegib-d4
Vismodegib-d4. Group: Biochemicals. Alternative Names: GDC 0449-d4; 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H10D4Cl2N2O3S, Molecular Weight: 425.3. US Biological Life Sciences.
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Vitalethine
Vitalethine. Group: Biochemicals. Alternative Names: 5, 14-Dioxo-9, 10-dithia-2, 6, 13, 17-tetraazaoctadecane dioic Acid. Grades: Highly Purified. CAS No. 143129-01-5. Pack Sizes: 50mg. Molecular Formula: C12H22N4O6S2, Molecular Weight: 382.46. US Biological Life Sciences.
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Vitalethine-d8
Vitalethine-d8. Group: Biochemicals. Alternative Names: 5, 14-Dioxo-9, 10-dithia-2, 6, 13, 17-tetraazaoctadecane dioic Acid-d8. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C12H14D8N4O6S2, Molecular Weight: 390.51. US Biological Life Sciences.
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Vitamin B1 Amine N-Propionaldehyde-N-maleimide
Vitamin B1 Amine N-Propionaldehyde-N-maleimide is a useful synthetic intermediate and a related compound of Thiamine (T344185). Thiamine or vitamin B1 is an essential nutrient required for carbohydrate metabolism and it is also involved in nerve function. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H23N6O3S Br, Molecular Weight: 415.5. US Biological Life Sciences.
Worldwide
VTX-27
Selective PKC inhibitor. VTX-27 is a potent and selective inhibitor of the PKCth enzyme, with over 1000-fold against classical isoforms and over 10,000-fold against atypical isoforms. Group: Biochemicals. Grades: Highly Purified. CAS No. 1321924-70-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H24ClFN6O, Form: Supplied as a. US Biological Life Sciences.
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VU0155041, Sodium Salt (cis-2- (3, 5-Dichlorophenyl carbamoyl ) cyclohexane carboxyl ic Acid Sodium Salt)
A highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7uM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventri cularlly (icv). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
VU 0285683
VU 0285683. Group: Biochemicals. Alternative Names: 3-(2-Pyridyl)-5-(3-fluoro-5-cyanophenyl)-1,2,4-oxadiazole. Grades: Highly Purified. CAS No. 327056-22-4. Pack Sizes: 10mg. Molecular Formula: C14H7FN4O, Molecular Weight: 266.23. US Biological Life Sciences.
Worldwide
VU 0357121
VU 0357121. Group: Biochemicals. Alternative Names: 4-Butoxy-N-(2,4-difluorophenyl)-benzamide. Grades: Highly Purified. CAS No. 433967-28-3. Pack Sizes: 25mg. Molecular Formula: C17H17F2NO2, Molecular Weight: 305.32. US Biological Life Sciences.
Worldwide
VU 0360172
VU 0360172. Group: Biochemicals. Alternative Names: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide Hydrochloride. Grades: Highly Purified. CAS No. 1309976-62-2. Pack Sizes: 10mg. Molecular Formula: C18H16ClFN2O, Molecular Weight: 330.78. US Biological Life Sciences.
Worldwide
VX-765
VX-765. Group: Biochemicals. Alternative Names: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide; Belnacasan. Grades: Highly Purified. CAS No. 273404-37-8. Pack Sizes: 5mg. Molecular Formula: C24H33ClN4O6, Molecular Weight: 509. US Biological Life Sciences.
A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 634908-75-1. Pack Sizes: 10mg. US Biological Life Sciences.
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WHI-P154
WHI-P154. Group: Biochemicals. Alternative Names: 4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline; 2-Bromo-4-[ (6, 7-dimethoxy-4-quinazolinyl) amino]phenol. Grades: Highly Purified. CAS No. 211555-04-3. Pack Sizes: 10mg. Molecular Formula: C16H14BrN3O3, Molecular Weight: 376.2. US Biological Life Sciences.
Potent tankyrase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 838818-26-1. Pack Sizes: 5mg, 25mg. Molecular Formula: C29H23N5O3S. US Biological Life Sciences.
Worldwide
Win 18446
Win 18446. Group: Biochemicals. Alternative Names: N,N'-1,8-Octanediylbis[2,2-dichloroacetamide; Bis-Diamine; Fertilysin; Fertilysine; N,N'-Bis(dichloroacetyl)-1,8-diaminooctane; N,N'-Bis(dichloroacetyl)-1,8-octamethylenediamine; N,N'-Octamethylenebis(2,2-dichloroacetamide); NSC 59354; Win 18441. Grades: Highly Purified. CAS No. 1477-57-2. Pack Sizes: 100mg. Molecular Formula: C12H20Cl4N2O2, Molecular Weight: 366.11. US Biological Life Sciences.
Worldwide
Withanolide A
Withanolide A. Group: Biochemicals. Alternative Names: (5α, 6α, 7α, 22R)-6, 7-epoxy-5, 20, 22-trihydroxy-1-oxo-ergosta-2, 24-dien-26-oic Acid δ-Lactone; (22R)-6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-5α-Ergosta-2,24-dien-26-oic Acid δ-Lactone; 6, 7-Epoxy-1H-cyclopenta [a]phenanthrene Ergosta-2,24-dien-26-oic Acid Deriv.; 5,20α-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide; 5α,20αF(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide; Withaniol. Grades: Highly Purified. CAS No. 32911-62-9. Pack Sizes: 10mg. Molecular Formula: C28H38O6, Molecular Weight: 470.6. US Biological Life Sciences.
Worldwide
Withanoside IV
Withanoside IV. Group: Biochemicals. Alternative Names: (1α,3 β,22R)-3-[(6-O- β-D-Glucopyranosyl- β-D-glucopyranosyl)oxy]-1,22,27-trihydroxy-ergosta-5,24-dien-26-oic Acid δ-Lactone. Grades: Highly Purified. CAS No. 362472-81-9. Pack Sizes: 1mg. Molecular Formula: C40H62O15, Molecular Weight: 782.91. US Biological Life Sciences.
Worldwide
Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide)
A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT; 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33 / Ser37 / Thr41 / Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Wnt Antagonist, C59
Cell-permeable. A potent Wnt signaling pathway inhibitor (IC50 = <0.11nM using Wnt-Luc reporter assay). Group: Biochemicals. Alternative Names: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl) Acetamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
WP1130 (Degrasyn)
A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
An agonist selective for muscarinic acetylcholine receptor (mAChR) subtype M1 (EC50 = 0.3, 5, 42, 52 and 92.5nM at M1, M3, M5, M4 and M2 receptors respectively). An antipsychotic agent. Used in improving cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 141064-23-5. Pack Sizes: 10mg. Molecular Formula: C??H??N?OS C?H?O. US Biological Life Sciences.
Worldwide
Xanthene-9-carboxylic Acid
Xanthene-9-carboxylic Acid is xanthrene derivative that is capable of inhibiting the TTR conformational changes facilitating amyloid fibril formation. Group: Biochemicals. Alternative Names: 9-Carboxyxanthene; 9H-Xanthen-9-carboxylic Acid; NSC 66208; Xanthanoic Acid; Xanthenecarboxylic Acid. Grades: Highly Purified. CAS No. 82-07-5. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Xanthomegnin (NSC264720)
Genotoxic mycotoxin. Antitumor compound. Potent iNOS (NOSII) inhibitor. Interferes with cellular respiratory processes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1685-91-2. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.
Worldwide
Xanthone
Xanthone. Group: Biochemicals. Alternative Names: 9H-Xanthen-9-one; Xanthen-9-one; 9-Oxoxanthene; 9-Xanthone; 9-Oxo-9H-xanthene; Benzophenone Oxide; Dibenzo-γ-pyrone; Diphenylene Ketone Oxide; Genicide; NSC 14978; Xanthenone; Xanthone. Grades: Highly Purified. CAS No. 90-47-1. Pack Sizes: 1g. Molecular Formula: C13H8O2, Molecular Weight: 196.2. US Biological Life Sciences.