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RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D. Group: Inhibitors. Alternative Names: RO0335; RO-0335; RO 0335. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.22. Appearance: Solid powder. Purity: >98%. IUPACName: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide. Canonical SMILES: O=C (NC1=CC=C (S (=O) (N)=O)C=C1Cl)CC2=CC=C (Br)C (OC3=CC (C#N)=CC (Cl)=C3)=C2F. Catalog: ACM867365762.
Ro 08-2750
Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief. Group: Inhibitors. Alternative Names: Ro 08-2750; Ro08-2750; Ro-08-2750; Ro 082750; Ro -082750; Ro082750. CAS No. 37854-59-4. Molecular formula: C13H10N4O3. Mole weight: 270.25. Appearance: Orange to red solid powder. Purity: >95%. IUPACName: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde. Canonical SMILES: O=CC1=C (C)C=C2N=C3C (NC (N=C3N (C)C2=C1)=O)=O. Catalog: ACM37854594.
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. Group: Inhibitors. Alternative Names: RO6889678; RO-6889678; RO 6889678. CAS No. 1578153-27-1. Molecular formula: C21H20ClFN4O5S. Mole weight: 494.92. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid. Canonical SMILES: O=C ([C@H]1N (CC2=C (C (OC)=O)[C@H] (C3=CC=C (F)C=C3Cl)N=C (C4=NC=CS4)N2)CCOC1)O. Catalog: ACM1578153271.
Rocaglamide
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia. Group: Inhibitors. Alternative Names: (1R)-2,3,3a,8b-Tetrahydro-1α,8bβ-dihydroxy-6,8-dimethoxy-3aβ-(4-methoxyphenyl)-N,N-dimethyl-3β-phenyl-1H-cyclopenta[b]benzofuran-2α-carboxamide. CAS No. 84573-16-0. Molecular formula: C29H31NO7. Mole weight: 505.6. Purity: 95%+. Catalog: ACM84573160.
Roflumilast-d3
Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Group: Inhibitors. Alternative Names: 3-(Cyclopropylmethoxy-d3)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; B 9302-107-d3; BY 217-d3; BYK 20869-d3. CAS No. 1189992-00-4. Molecular formula: C17H11D3Cl2F2N2O3. Mole weight: 406.23. Appearance: Crystallin Solid. Canonical SMILES: [2H]C1 (CC1)C ([2H]) ([2H])OC2=C (C=CC (C (NC3=C (Cl)C=NC=C3Cl)=O)=C2)OC (F)F. Catalog: ACM1189992004.
Ropinirole-d14hcl(di-N-propyl-d14)
Heterocyclic Organic Compound. CAS No. 1132746-05-4. Molecular formula: 310.92. Purity: 99 atom % D. Catalog: ACM1132746054.
Ropivacaine Related Compound B (50 mg) ((R)-(+)-1-Propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)-amide hydrochloride monohydrate)
Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.IC50 value:Target: TNF alphaProphylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP. Group: Inhibitors. Alternative Names: N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE;ROQUINIMEX;LINOMIDE;LS-2616;1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide.
Rosa Centifolia Flower Extract
Triple plant extract made of Pale Rose, Jasmine, and Daisy flowers providing excellent soothing and anti-irritating properties. Excellent soothing and anti-irritating properties combined with skin-conditioning and smoothing effects. Uses: All kinds of skin care products aimed to soothe the skin. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84604-12-6 / 90045-94-6 / 84776-11-4 / 11138-66-2 / 532-32-1 / 24634-61-5. Appearance: Clear amber liquid, herbal odor. Catalog: CI-SC-0834.
Rosa Hybrid Flower Extract
Rosa hybrid flower extract, popularly known as "black rose," is a direct variety of Rosa baccara, one of the world's most famous roses. Its velvety petals and tonality, in addition to its anti-aging cosmetic properties, are easily associated with luxury products designed for consumers interested in more exclusive cosmetics. Uses: Anti-aging and anti-wrinkle products, luxury creams, lotions & serums. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 93062-88-5 / 532-32-1 / 24634-61-5. Catalog: CI-SC-0937.
Rosamultin
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. Rosamultin has inhibitory effects against HIV-1 protease. Rosamultin has the potential for treating H2O2-induced oxidative stress injury through its antioxidant and antiapoptosis effects. Group: Inhibitors. CAS No. 88515-58-6. Molecular formula: C36H58O10. Mole weight: 650.85. Appearance: Powder. Purity: 0.98. IUPACName: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R, 2R, 4aS, 6aR, 6aS, 6bR, 8aR, 10R, 11R, 12aR, 14bS)-1, 10, 11-trihydroxy-1, 2, 6a, 6b, 9, 9, 12a-heptamethyl-2, 3, 4, 5, 6, 6a, 7, 8, 8a, 10, 11, 12, 13, 14b-tetradecahydropicene-4a-carboxylate. Canonical SMILES: CC1CCC2 (CCC3 (C (=CCC4C3 (CCC5C4 (CC (C (C5 (C)C)O)O)C)C)C2C1 (C)O)C)C (=O)OC6C (C (C (C (O6)CO)O)O)O. Catalog: ACM88515586.
Rose Flower Extract
Wild Rose Extract made from rose buds and petals (Rosa Canina) dissolved in glycerin and water. Contains various volatile oils which have made them useful in tonics and anti-irritant solutions. Uses: Serums, creams & lotions, skin cleansers, sun- and after-sun care, sunscreens. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84696-47-9 / 122-99-6. Appearance: Medium to dark amber liquid, characteristic odor. Catalog: CI-SC-0677.
Rose Hip Oil
Natural oil extracted from the seeds of the rose hip or wildrose. High in linoleic & linolenic essential fatty acids which are key components of epidermal skin cells. Expeller-pressed, refined. Uses: Creams, lotions, protecting creams, ointments, bath oils, makeup & sun care products, personal & baby care products. Group: Heterocyclic organic compound. Alternative Names: Rosehips(Rosacanina)oil; ROSE(ROSAMULTIFLORA)OIL; Rose Hips Seed Oil;Rose Hip Oil. CAS No. 84603-93-0. Appearance: Clear yellowish liquid. Catalog: ACM84603930.
Rosehips Extract
Extract obtained from Rosa Canina (Rose) hips. Contains 20% extract dissolved in water and glycerin. Has toning, soothing and firming properties. Uses: Cleansers, moisturizers, creams, lotions, and gels. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84696-47-9 / 122-99-6. Appearance: Light to medium amber, to orange liquid, characteristic odor. Catalog: CI-SC-0848.
Roselle Plant Extract
Extract obtained from Hibiscus Sabdariffa (Roselle) flowers dissolved in water and glycerin. Has anti-oxidant properties and inhibits elastin degradation, resulting in maintaining the skin's elasticity and consequent anti-aging effects. It is useful for formulations targeting skin tone, anti-cellulite and skin-firming products. Uses: Anti-aging, anti-cellulite and anti-wrinkle products, firming & moisturizing products. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84775-96-2 / 24634-61-5 / 590-00-1 / 532-32-1. Catalog: CI-SC-0680.
Rosemary Leaf Extract
Rosemary leaf extract in a base of glycerin and water. Contains 20% extract dissolved glycerin and water. Uses: Creams & lotions, skin cleansers, toners, body wraps, hair care products, dry scalp, massage oils, and deodorants. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84604-14-8 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0672.
Rosemary Leaf Extract, USDA Certified Organic
Organic Rosemary leaf extract. Contains 20% extract dissolved glycerin. Uses: Creams & lotions, skin cleansers, toners, body wraps, hair care products, dry scalp, massage oils, and deodorants. Group: Skin actives. CAS No. 56-81-5/84604-14-8. Appearance: Colorless, odorless, viscous liquid. Catalog: CI-SC-0705.
Rosiglitazone hydrochloride
Rosiglitazone (BRL 49653) hydrochloride is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone hydrochloride is a TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone hydrochloride can be used in the research of obesity and diabetes, senescence, ovarian cancer. Group: Inhibitors. Alternative Names: 5-[4-[2-[N-Methyl-N- (pyridinyl) amino]ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride. CAS No. 302543-62-0. Molecular formula: C18H19N3O3S.HCl. Mole weight: 393.89. Appearance: Powder. Purity: 0.98. IUPACName: 5-[[4-[2-[Methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride. Canonical SMILES: CN (CCOC1=CC=C (C=C1)CC2C (=O)NC (=O)S2)C3=CC=CC=N3. Cl. Catalog: ACM302543620.
Rostratin A is a disulfide found in the marine-derived fungus Exserohilum rostratum. Group: Marine natural products. CAS No. 752236-16-1. Purity: 95%+. Catalog: ACM752236161.
Round Leaf Buchu Extract
Extract obtained from Barosma Betulina (Round Leaf Buchu) leaves, one of the most important medicinal plants in South Africa. It is able to modulate the action of sebocytes to reduce excess sebum, refine enlarged pores and mattify shiny patches in oily skin, thus improving the skin's overall appearance and texture. Uses: Cosmetic applications include treatments for oily skin, sebo-regulating products for oily or blemished skin. Group: Skin actives. CAS No. 107-88-0/77-92-9. Catalog: CI-SC-0589.
Royal Jelly Extract
Royal jelly is a fluid secretion that's secreted from glands on the heads of worker bees. It is synthesized from pollen, water, and honey, mixed with saliva, hormones, and vitamins. Royal Jelly Extract is a suspension of royal jelly (about 20%) in glycerin and water (about 80%), it contains mainly amino acids, proteins, carbohydrates, and lipids. It provides good skin-purifying activity and has excellent skin-conditioning and moisturizing properties. Uses: Anti-aging products, moisturizing and nourishing creams & lotions, anti-irritant treatments. Group: Skin actives. CAS No. 56-81-5/8031-67-2. Appearance: Viscous liquid. Catalog: CI-SC-0702.
Heterocyclic Organic Compound. Alternative Names: (R)-(-)-TERT-LEUCINOL;(R)-TERT-LEUCINOL;(R)-2-AMINO-3,3-DIMETHYL-1-BUTANOL;H-D-TLE-OL;H-D-(TBU)GLY-OL;D-ALPHA-T-BUTYLGLYCINOL;D-T-LEUCINOL;D-T-BUTYLGLYCINOL. CAS No. 112245-09-7. Molecular formula: C6H15NO. Mole weight: 117.19. Purity: 0.96. IUPACName: (2R)-2-amino-3,3-dimethylbutan-1-ol. Canonical SMILES: CC(C)(C)C(CO)N. Density: 0.9g/mL at 25°C(lit.). Catalog: ACM112245097.
(R)-(+)-Tetrahydro-3-furylamine p-toluenesulfonate salt
Furans. Alternative Names: (R)-(+)-3-Aminotetrahydrofuran p-toluenesulfonate salt. CAS No. 111769-27-8. Molecular formula: C4H9NO·C7H8O3S. Mole weight: 259.32. Purity: 0.98. Catalog: ACM111769278.
Rubber, natural
Isoprene, stabilized appears as a clear colorless liquid with a petroleum-like odor. Density 5.7 lb / gal. Flash point -65°F. Boiling point 93°F. May polymerize exothermically if heated or contaminated. If polymerization takes place inside a closed container, the container may rupture violently. Less dense than water and insoluble in water. Vapors heavier than air.;Liquid; OtherSolid;OtherSolid;VERY VOLATILE COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Group: Heterocyclic organic compound. Alternative Names: RUBBER LATEX;RUBBERFUME. CAS No. 9006-4-6. Molecular formula: C5H8;CH2=C(CH3)CH=CH2;C5H8. Mole weight: 68.12g/mol. IUPACName: 2-methylbuta-1,3-diene. Canonical SMILES: CC(=C)C=C. Density: 0.681 at 68 °F (USCG, 1999);0.679 g/cu cm at 20 °C;0.906-0.916 g/cu cm @ 20 °C;Relative density (water = 1): 0.7. ECNumber: 201-143-3; 232-689-0; 614-502-8; 618-362-9; 618-550-0. Catalog: ACM9006046.
Rubber Oligomer 3
Rubber Oligomer 3. CAS No. 114123-73-8. Molecular formula: C21H40. Mole weight: 292.55. Appearance: White powder. Purity: 0.98. Catalog: ACM114123738.
Rubitecan
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. Group: Inhibitors. Alternative Names: 9-Nitrocamptothecin. CAS No. 91421-42-0. Molecular formula: C20H15N3O6. Mole weight: 393.3. Appearance: Solid. Purity: 98%+. Canonical SMILES: O=C1[C@] (O) (CC)C2=C (CO1)C (N3CC4=CC5=C ([N+] ([O-])=O)C=CC=C5N=C4C3=C2)=O. Catalog: ACM91421420.
Rubrene
TGA/DSC Lot specific traces available upon request. Uses: Organic electronic material useful as oled dopant (red, λem = 550nm) and as p-type organic semiconductor. carrier mobilities of 8-20 cm2 / vs can be achieved in ofets based on single crystals of sublimed rubrene. Group: Organic light emitting diode (oled). Alternative Names: 5,6,11,12-Tetraphenylnaphthacene. CAS No. 517-51-1. Molecular formula: C42H28. Mole weight: 532.67 g/mol. Purity: 95%+. IUPACName: 5,6,11,12-tetraphenyltetracene. Canonical SMILES: C1=CC=C (C=C1) C2=C3C=CC=CC3=C (C4=C (C5=CC=CC=C5C (=C24) C6=CC=CC=C6) C7=CC=CC=C7) C8=CC=CC=C8. ECNumber: 208-242-0. Catalog: ACM517511.
Rucaparib Camsylate
Rucaparib camsylate is a potent, orally available inhibitor of poly ADP-ribose polymerase (PARP) 1 and 2. Group: Inhibitors. Alternative Names: AG14699 (as phosphate salt); AG 14699; AG-14699; AG014447 (as free base); AG-014447; AG 014447; PF01367338; PF-01367338; PF 01367338; Rucaparib camsylate; Rubraca. CAS No. 1859053-21-6. Molecular formula: C29H34FN3O5S. Mole weight: 555.67. Appearance: Solid powder. Purity: >98%. IUPACName: Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-(4-((methylamino)methyl)phenyl)-6H-pyrrolo(4,3,2-ef)(2)benzazepin-6-one (1:1). Canonical SMILES: O=S (C[C@@]1 (C2 (C)C)C (C[C@@]2 ([H])CC1)=O) (O)=O. O=C (NCC3)C4=CC (F)=CC5=C4C3=C (C6=CC=C (CNC)C=C6)N5. Catalog: ACM1859053216.
Alfa Chemistry manufactures Ruthenium Chloride Trihydrate. Ruthenium(III) Chloride Trihydrate is generally immediately available in most volumes. All specifications can be customized. Please request a quote above to receive pricing information based on your specifications. Uses: They are an excellent source of ruthenium chloride for applications requiring solubilized compound solutions packaging, bulk quantitymaterials. Group: Ruthenium series catalysts. Alternative Names: Ruthenium(III) chloride; trichlororuthenium trihydrate; ruthenium(3+) trihydrate. CAS No. 13815-94-6. Molecular formula: RuCl3 · 3H2O. Mole weight: 261.47 g/mol. Appearance: solid. Purity: (5N) 99.999%. IUPACName: trichlororuthenium;trihydrate. Canonical SMILES: [Ru+3].[Cl-].[Cl-].[Cl-].O.O.O. Catalog: ACM13815946-1.