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Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP). Group: Inhibitors. CAS No. 219680-11-2. Molecular formula: C19H20FN5O4. Catalog: ACM219680112.
Zegocractin, also known as CM4620, is a selective Orai1 inhibitor, prevents Ca2+ entry in acinar cells. The intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species. SOCE via STIM1/Orai complexes promotes activation and fibroinflammatory gene expression within pancreatic stellate cells. CM4620 also decreased myeloperoxidase activity and inflammatory cytokine expression in pancreas and lung tissues, fMLF peptide-induced oxidative burst in human neutrophils, and cytokine production in human peripheral blood mononuclear cells (PBMCs) and rodent PaSCs, indicating that Orai1/STIM1 channels participate in the inflammatory responses of these cell types during acute pancreatitis. Group: Inhibitors. Alternative Names: CM-4620; CM 4620; CM4620; Zegocractin. CAS No. 1713240-67-5. Molecular formula: C19H11ClF3N3O3. Mole weight: 421.76. Appearance: Solid powder. Purity: >98%. IUPACName: N-(5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide. Canonical SMILES: O=C (NC1=NC=C (C2=C (Cl)C=C (OC (F) (F)O3)C3=C2)N=C1)C4=C (C)C=CC=C4F. Catalog: ACM1713240675.
Zeniplatin
Heterocyclic Organic Compound. Alternative Names: ZENIPLATIN;(sp-4-2)-[2, 2-Bis(aminc~nethyl)-1, 3-propanediol-N, N, ][1, 1-cyclobutanedicarboxylato(2-)-O, O']platinum. CAS No. 111490-36-9. Molecular formula: C11H20N2O6Pt. Mole weight: 471.36. Catalog: ACM111490369.
Zerumbone
Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity. Group: Inhibitors. Alternative Names: ZERUMBONE ((2E,6E,10E)-2,6,9,9-TETRAMETHYLCYCLOUNDECA-2,6,10-TRIEN-1-ONE); Zerumbone. CAS No. 471-05-6. Molecular formula: C15H22O. Mole weight: 218.3. Appearance: White-off white powder. Purity: 0.98. IUPACName: (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one. Canonical SMILES: CC1=CCC(C=CC(=O)C(=CCC1)C)(C)C. Catalog: ACM471056.
Z-Gly-OH, also known as N-benzyloxycarbonylglycine, is an amino acid widely used in solution phase peptide synthesis. Uses: Z-gly-oh is a versatile reagent that can be used to synthesize a variety of compounds such as: glycine-derived peptides like z-gly-dl-ala-obzl and z-gly-l-ala-obzl glycine n-substituted amides such as glycine-n-methylamide hydrochloride and glycine-n-isopropylamide hydrochloride. Group: Amino acids. Alternative Names: Z-Glycine. CAS No. 1138-80-3. Molecular formula: C6H5CH2OOCNHCH2COOH. Mole weight: 209.2. Canonical SMILES: OC(=O)CNC(=O)OCc1ccccc1. ECNumber: 214-516-0. Catalog: ACM1138803.
Heterocyclic Organic Compound. CAS No. 1131605-46-3. Catalog: ACM1131605463.
Zidovudine
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Group: Inhibitors. Alternative Names: 3-AZIDO-3-DEOXYTHYMIDINE; 1-(4-azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1h-pyrimidine-2, 4-dione; 1-((2R, 4S, 5S)-4-AZIDO-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-METHYL-1H-PYRIMIDINE-2, 4-DIONE; AZT; AZIDOTHYMIDINE; ZIDOVUDINE; 3'-azido-3'-deoxy-thymidin; bwa509u. CAS No. 30516-87-1. Molecular formula: C10H13N5O5. Mole weight: 283.24. Purity: 0.9993. Catalog: ACM30516871.
Zileuton
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties. Group: Inhibitors. Alternative Names: (±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea. CAS No. 111406-87-2. Molecular formula: C11H12N2O2S. Mole weight: 236.29. Appearance: A Crystalline Solid. Purity: 0.99. Catalog: ACM111406872.
Zileuton-d4
Zileuton-d4 is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties. Group: Inhibitors. Alternative Names: N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyurea-d4; A-64077-d4; Abbott 64077-d4; Leutrol-d4; Zyflo-d4. CAS No. 1189878-76-9. Molecular formula: C11H8D4N2O2S. Mole weight: 240.31. Appearance: White Solid. Purity: 0.96. IUPACName: 1-[1-(1-benzothiophen-2-yl)-1,2,2,2-tetradeuterioethyl]-1-hydroxyurea. Canonical SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O. Catalog: ACM1189878769.
Zinc acetate dehydrate was used as seeds to grow ZnO nanorods on the microfibers of PET (polyethylene terephthalate) fabric. It may be used in the synthesis of layered Zn-arylphosphonates with potential application in sorption, ion exchange or catalysis. Also it may be used in the ultrasonic preparation of zinc sulfide nanoparticles coated on silica particles. Uses: Zinc acetate [zn(c2h3o2)2] is used as a mordant for dyeing cloth, as a wood preservative, as a laboratory agent, and as a dietary supplement.zinc acetate has been used as an excipient in a variety of pharmaceutical formulations including topical gels, lotions, and solutions, and subcutaneous injections. it has also been investigated for use in an oral controlled-release formulation for water-soluble drugs in combination with sodium alginate and xanthan gum. therapeutically, zinc acetate has been used in oral capsules for the treatment of wilson's disease. zinc acetate has also been demonstrated to be effective as a spermicide in vaginal contraceptives. Group: Organic zinc. Alternative Names: Acetic acid,zine salt,dihydrate. CAS No. 5970-45-6. Molecular formula: C4H10O6Zn. Mole weight: 219.5. Appearance: White solid. Purity: 95%+. IUPACName: Zinc;diacetate;dihydrate. Canonical SMILES: CC(=O)[O-].CC(=O)[O-].O.O.[Zn+2]. Density: 1.84 g/mL at 20 °C (lit.). Catalog: ACM5970456-1.
Zinc Borate
Zinc borate appears as a white powder of variable composition. (typically 45% ZnO, 34% B2O3 and 20% H2O). Slightly soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used as a fungus and mildew inhibitor, to fire proof textiles, and for other uses.;DryPowder; OtherSolid; PelletsLargeCrystals. Group: Resin additives. CAS No. 1332-07-6. Molecular formula: B2O6Zn3. Mole weight: 313.8g/mol. Appearance: White solid. IUPACName: trizinc;diborate. Canonical SMILES: B([O-])([O-])[O-]. B([O-])([O-])[O-]. [Zn+2]. [Zn+2]. [Zn+2]. Density: 3.64 g/cm³ (20°C). ECNumber: 215-566-6;238-763-9. Catalog: ACM1332076.
Zinc bromide
Zinc bromide (ZnBr2) is an inorganic compound with the chemical formula ZnBr2. It is a colourless salt that shares many properties with zinc chloride (ZnCl2), namely a high solubility in water forming acidic solutions, and solubility in organic solvents. It is hygroscopic and forms a dihydrate ZnBr2 · 2H2O. Uses: Zinc bromide is a white crystalline powder prepared by dissolving zinc carbonate in hydrobromic acid. zinc chloride (zncl2) is a white granular crystal made by the action of hydrochloric acid on zinc. zinc iodide (zni2) is a white powder made by dissolving zinc in ionic acid. all of the zinc halides are soluble in water, alcohol, and ether. they were all used as halides for the collodion emulsion processes. Group: Metal & ceramic materials. Alternative Names: Dibromozinc. CAS No. 7699-45-8. Molecular formula: Br2Zn. Mole weight: 225.2. Appearance: White to pale cream beads. Purity: 99%+. IUPACName: Zinc;dibromide. Canonical SMILES: [Zn+2].[Br-].[Br-]. Density: 4.22 g/cm³. Catalog: ACM7699458.
White fine amorphous powder, odorless and tasteless. Specific gravity 4.42-4.45, insoluble in water and alcohol, slightly soluble in ammonia, soluble in dilute acid and sodium hydroxide. Alternative Names: Zinc monocarbonate. CAS No. 3486-35-9. Molecular formula: C2H8O13Zn5. Mole weight: 125.39. Appearance: White powder. Density: 4.398 g/cm³. ECNumber: 222-477-6. Catalog: ACM3486359.
Zinc Dimethyldithiocarbamate
Ziram is an odorless white powder. (NTP, 1992);DryPowder;WHITE POWDER.;Odorless white powder. Group: Plastic additives. CAS No. 137-30-4. Molecular formula: ((CH3)2NCS.S)2Zn; C6H12N2S4Zn; C6H12N2S4Zn. Mole weight: 305.8g/mol. IUPACName: zinc;N,N-dimethylcarbamodithioate. Canonical SMILES: CN(C)C(=S)[S-].CN(C)C(=S)[S-].[Zn+2]. Density: 1.66 at 77 °F (NTP, 1992);1.66 @ 25 °C referred to water at 4 °C;1.7 g/cm³. ECNumber: 205-288-3. Catalog: ACM137304.
Pyrithione zinc, also commonly known as zinc pyrithione, has antibacterial, antimicrobial, and antifungal properties that can help treat seborrheic dermatitis (also called dandruff), scalp psoriasis, and acne. Uses: Zpt-50 is the most important antidandruf agent in the world, which used for more than 30 years in shampoo. zpt-50 shows excellent inhibiting effect on pytyrosporum ovale that causes dandruff. zpt has broad spectrum bactericide and marine antifouling material, and is well used for cosmetic, shampoo, skins medicine, adhesive and coating painting and so on. Group: Inhibitors. Alternative Names: ZPT. CAS No. 13463-41-7. Molecular formula: C10H8N2O2S2Zn. Mole weight: 317.4. Appearance: White to slight yellow powder or white suspension. Purity: 0.98. IUPACName: Zinc;1-oxidopyridin-1-ium-2-thiolate. Canonical SMILES: C1=CC=[N+](C(=C1)[S-])[O-]. C1=CC=[N+](C(=C1)[S-])[O-]. [Zn+2]. Density: 1.782 g/cm3. ECNumber: 236-671-3. Catalog: ACM13463417-2.
Zinc Stannate
Zinc Hydroxystannate and Zinc Stannate are active smoke suppressants as well as flameretardants. Their superior performance is because of their dual phase mechanism. In addition to exhibiting vapor phase action, similar to Antimony Trioxide, they also exhibit condensed phase action during which they act as excellent char promoters. The condensed phase action of Zinc Hydroxystannate and Zinc Stannate enhances the formation of a thermally stable carbonaceous layer at the expense of aromatic, volatile and flammable products. These products exhibit synergy with Zinc Borate, Ammonium Octamolybdate and Antimony Trioxide. Uses: Zinc hydroxystannate and zinc stannate are effective in halogen free and halogen containing systems. although generally, there is little difference in the effectiveness of zinc hydroxystannate and zinc stannate, the latter is the preferred additive for polymers that are processed at temperatures above 200oc. Group: Heterocyclic organic compound. Alternative Names: ZnSnO3. CAS No. 12036-37-2. Molecular formula: ZnSnO3. Mole weight: 232.06. Appearance: White powder. Density: g/cm³. Catalog: ACM12036372.
Zinc Stearate
Zinc stearate is a zinc soap that is widely used industrially. In this context, soap is used in its formal sense, a metal salt of a fatty acid. It is a White solid that repels water. It is insoluble in polar solvents such as alcohol and ether but soluble in aromatic hydrocarbons (e.g., benzene) and chlorinated hydrocarbons when heated. It is the most powerful mold release agent among all metal soaps. It contains no electrolyte and has a hydrophobic effect. Its main application areas are the plastics and rubber industry, where it is used as a releasing agent and lubricant which can be easily incorporated.Zinc carboxylates, e.g. basic zinc acetate, adopt complex formulas, and are not simply dicarboxylates of zinc. Instead the formula for most zinc carboxylates is Zn4O(O2CR)6, consisting of a Zn4O6+ core with carboxylate ligands spanning the edges. Uses: It is widely used as a release agent for the production of many kinds of objects rubber, poly urethane, poly ester processing system, powder metallurgy. these applications exploit its "non-stick" properties. in cosmetics, zinc stearate is a lubricant and thickening to improve texture. it is an "activator" for rubber vulcanization by sulfur and accelerators. as discovered in the early days of vulc. Group: Heterocyclic organic compound. Alternative Names: Stearic acid, zinc salt. CAS No. 557-05-1. Molecular formula: C36H70ZnO4. Mole weight: 632.35. Appearance: White powder w
Zinc tetrafluoroborate hydrate
Degree of hydration, 6-7. Group: Metal & ceramic materials. Alternative Names: Borate(1-), tetrafluoro-, zinc (2:1), hexahydrate (9CI). CAS No. 27860-83-9. Molecular formula: Zn(BF4)2·xH2O. Mole weight: 257. Appearance: White powder. Purity: 99%+. IUPACName: Zinc;ditetrafluoroborate;hydrate. Canonical SMILES: [B-](F)(F)(F)F. [B-](F)(F)(F)F. O. [Zn+2]. Density: 2.12 g/mL at 25 °C (lit.). Catalog: ACM27860839.
Zingibroside R1
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity.Zingibroside R1 possesses some anti-HIV-1 activity.Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC50=91.3 μM). Group: Inhibitors. CAS No. 80930-74-1. Molecular formula: C42H66O14. Mole weight: 795. Appearance: Powder. Purity: 0.98. IUPACName: (2S, 3S, 4S, 5R, 6R)-6-[[(3S, 4aR, 6aR, 6bS, 8aS, 12aS, 14aR, 14bR)-8a-carboxy-4, 4, 6a, 6b, 11, 11, 14b-heptamethyl-1, 2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14, 14a-tetradecahydropicen-3-yl]oxy]-3, 4-dihydroxy-5-[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid. Canonical SMILES: CC1 (CCC2 (CCC3 (C (=CCC4C3 (CCC5C4 (CCC (C5 (C)C)OC6C (C (C (C (O6)C (=O)O)O)O)OC7C (C (C (C (O7)CO)O)O)O)C)C)C2C1)C)C (=O)O)C. Catalog: ACM80930741.
Zipalertinib
Zipalertinib, also known as TAS6417, CLN-081, is a Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. TAS6417 inhibited EGFR with various exon 20 insertion mutations more potently than it inhibited the WT. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. These characteristics led to marked tumor regression in vivo in both a genetically engineered model and in a patient-derived xenograft model. Furthermore, TAS6417 provided a survival benefit with good tolerability in a lung orthotopic implantation mouse model. Group: Inhibitors. Alternative Names: TAS6417; TAS-6417; TAS 6417; CLN-081; CLN081; CLN081; Zipalertinib. CAS No. 1661854-97-2. Molecular formula: C23H20N6O. Mole weight: 396.45. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl)acrylamide. Canonical SMILES: NC1=C2C (N3C (C (C) =C[C@@H] (C3) NC (C=C) =O) =C2C4=CC5=CC=CC=C5N=C4) =NC=N1. Catalog: ACM1661854972.
Alfa Chemistry produces UiO-66 as part of a comprehensive catalog of 2D materials products. We can guide customers through material characterization and selection. Powder and other forms are available upon request. Request a quote to receive pricing information based on your specifications. Uses: 1) gas storage material and adsorption material 2) the rigid structure of uio-66 is a good catalyst support. Group: Porous materials mof, cof. Alternative Names: UiO-66; Zr-BDC; UiO-66(Zr); UiO-66-P; (Zr6O4(OH)4(1,4 dicarboxybenzene)) MOF. CAS No. 1072413-80-9. Molecular formula: Zr6O4(OH)4(C8H6O4)6. Mole weight: 1627.99 g/mol. Appearance: White powder. Purity: 99.9995% or higher. Catalog: ACM1072413809.
Zirconium(IV) Oxide, Yttria stabilized Nanopowder nanodots or nanocrystals are white hHigh surface area particles available in monoclinic or as stabilized or doped with yttria (yttrium oxide), calcia (calcium oxide), or magnesia (magnesium oxide), or phosphorized zirconia. Group: Nanoparticles & nanopowders. Alternative Names: Yttria-stabilized zirconia fibers. CAS No. 308076-80-4. Molecular formula: ZrO2 / Y2O3. Mole weight: 349g/mol. Appearance: White Powder. Purity: 20 mol % yttria, 3 mol % yttria, 8 mol % yttria, 10 mol % yttria. IUPACName: dioxozirconium; oxo(oxoyttriooxy)yttrium. Canonical SMILES: O=[Y]O[Y]=O.O=[Zr]=O. Catalog: ACM308076804.
Zirconium-Nickel Sputtering Target
Alloys. CAS No. 11146-74-0. Purity: 0.9995. Catalog: ACM11146740.
Zirconium oxide dichloride
Zirconium oxychloride appears as white or yellow silky odorless crystals.;Liquid; PelletsLargeCrystals. Group: Metal & ceramic materials. CAS No. 7699-43-6. Molecular formula: ZrOCl2;Cl2H2OZr. Mole weight: 180.14g/mol. IUPACName: oxozirconium;dihydrochloride. Canonical SMILES: O=[Zr].Cl.Cl. Density: greater than 1 at 68 °F (USCG, 1999);1.91. ECNumber: 231-717-9. Catalog: ACM7699436.
Zirconium Triselenide (ZrSe3)
ZrSe3 is a semiconductor having an indirect bandgap of ~1.1 eV and is diamagnetic. The layers are stacked together via van der Waals interactions and can be exfoliated into thin 2D layers. Zirconium Triselenide belongs to the group-IV transition metal trichalcogenides. Uses: Zirconium triselenide (zrse3) single crystals can be used to prepare monolayer and few-layer zrse3 by mechanical or liquid exfoliation. zirconium triselenide powder is suitable for liquid chemical exfoliation to prepare zrse3 nanosheets and nanoparticles down to few-layer films.zirconim triselenide has applications in polarized light emitting and photodetecting devices related to its quasi-one dimensional properties such as high anisotropy ratios in conductivity and linear dichroism. zirconium triselenide has also great application potentials in thermal energy batteries, near-infrared imaging, gas sensors, photodetectoros and solar cells. Group: Trichalcogenides. Alternative Names: Zirconium triselenide, Zirconium selenides. CAS No. 12166-53-9. Mole weight: 328.10 g/mol. Appearance: Black. Purity: >99.995 %. Catalog: ACM12166539.
Zirconium Trisulfide (ZrS3) Crystal
Zirconium trisulfide (ZrS3) is a typical representative of layered transition metal trichalcogenides (TMTCs). ZrS3 is an indirect gap semiconductor as its bulk and its monolayer undergoes an indirect to direct band gap transition with increasing tensile strain. ZrS3 layers possess a pseudo one-dimensional nature where each layer consists of ZrS3 chains extending along the b-lattice direction. Uses: Zrs3 has potential applications in thermal batteries, perovskite solar cells, perovskite light-emtting diodes and electronics such as in-plane anisotropic fets. it can also be used in optoelectronics such as polarization-sensitive photodetectors and thermoelectric, piezoelectric, and ferroelectric devices. see the applications tab for more details. Group: Trichalcogenides. Alternative Names: Zirconium trisulphide. CAS No. 12166-31-3. Mole weight: 187.42 g/mol. Appearance: Red brown. Purity: ≥ 99.999%. Catalog: ACM12166313.
ZONYL FS-300 is a fluorosurfactant known for its ability to reduce liquid surface tension and provide unique properties such as excellent wetting, spreading and leveling capabilities. Uses: Zonyl fs-300 fluorosurfactant designed for industrial applications including coatings, inks, adhesives and cleaning products. it is a nonionic fluorosurfactant, which means it is electrically neutral and contains no charged groups. this feature makes it compatible with a variety of formulations. CAS No. 197664-69-0. Molecular formula: RfCH2CH2O(CH2CH2O)xH. Appearance: liquid. Purity: 0.96. Density: 1.10±0.05 g/mL at 20 °C. Catalog: ACM197664690.
ZONYL(R) TBS, NH(4)(+)-FORM
Heterocyclic Organic Compound. CAS No. 111019-20-6. Purity: 0.96. Catalog: ACM111019206.
Zotarolimus
Zotarolimus, also known as ABT-578 and A-179578, is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Coronary stents reduce early complications and improve late clinical outcomes in patients needing interventional cardiology. Medtronic are using zotarolimus as the anti-proliferative agent in the polymer coating of their Endeavor and Resolute products. Group: Inhibitors. Alternative Names: A-179578; A 179578; A179578; ABT578; ABT-578; ABT 578; Endeavor; Zotarolimus; Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-. CAS No. 221877-54-9. Molecular formula: C52H79N5O12. Mole weight: 966.23. Appearance: Solid powder. Purity: >95%. IUPACName: (3S, 6R, 7E, 9R, 10R, 12R, 14S, 15E, 17E, 19E, 21S, 23S, 26R, 27R, 34aS)-9, 27-dihydroxy-10, 21-dimethoxy-3-{(1R)-2-[(1S, 3R, 4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-1-methylethyl}-6, 8, 12, 14, 20, 26-hexamethyl-4, 9, 10, 12, 13, 14, 21, 22, 23, 24, 25, 26, 27, 32, 33, 34, 34a-heptadecahydro-3H-23, 27-epoxypyrido[2, 1-c][1, 4]oxazacyclohentriacontine-1, 5, 11, 28, 29(6H, 31H)-pentone. Canonical SMILES: O=C ([C@@] (CCCC1) ([H])N1C (C ([C@@]2 (O)[C@H] (C)CC[C@@] (O2) ([H])C[C@H] (OC)/C (C)=C/C=C/C=C/[C@@H] (C)C[C@@H] (C)C ([C@H] (OC)[C@H] (O)/C (C)=C/[C@H]3C)=O)=O)=O)O[C@H] ([C@H] (C)C[C@H]4C[C@@H] (OC)[C@@H] (N5N=NN=C5)CC4)CC3=O. Catalog: ACM221877549.
z-Phe-arg-ome hcl
Heterocyclic Organic Compound. Alternative Names: Z-PHE-ARG-OME HCL. CAS No. 113715-88-1. Molecular formula: C24H32ClN5O5. Mole weight: 505.99. Catalog: ACM113715881.
z-Sar-pro-arg-oh
Heterocyclic Organic Compound. Alternative Names: Z-SAR-PRO-ARG-OH. CAS No. 112898-31-4. Molecular formula: C22H32N6O6. Mole weight: 476.53. Catalog: ACM112898314.
Z-VAD(OH)-FMK
Z-VAD(OH)-FMK, also known as Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone, is an irreversible tripeptide inhibitor of all caspases. Group: Inhibitors. Alternative Names: Z-VAD(OH)-FMK; Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone. CAS No. 161401-82-7. Molecular formula: C21H28FN3O7. Mole weight: 453.47. Appearance: Solid powder. Purity: >98%. IUPACName: (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid. Canonical SMILES: O=C (O)C[C@@H] (C (CF)=O)NC ([C@H] (C)NC ([C@H] (C (C)C)NC (OCC1=CC=CC=C1)=O)=O)=O. Catalog: ACM161401827.
ZX-29
ZX-29 is a potent and selective ALK inhibitor for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. Group: Inhibitors. Alternative Names: ZX-29; ZX29; ZX 29. CAS No. 2254805-62-2. Molecular formula: C23H28ClN7O3S. Mole weight: 518.03. Appearance: Solid powder. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide. Canonical SMILES: CS (=O) (NC1=CC=CC=C1NC2=NC (NC3=CC=C (N4CCN (C)CC4)C=C3OC)=NC=C2Cl)=O. Catalog: ACM2254805622.
ZZW-115
ZZW-115 is a potent NUPR1 inhibitor. ZZW-115 induces ferroptosis in a mitochondria-dependent manner. ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents. In addition, ZZW-115-treatment increases the accumulation of hydroperoxided lipids in these cells. ZZW-115-induced mitochondrial morphological changes, compatible with the ferroptotic process, as well as mitochondrial network disorganization and strong mitochondrial metabolic dysfunction, which are rescued by both Fer-1 and N-acetylcysteine (NAC). Of note, the expression of TFAM, a key regulator of mitochondrial biogenesis, is downregulated by ZZW-115. Group: Inhibitors. Alternative Names: ZZW-115; ZZW 115; ZZW115. CAS No. 801991-87-7. Molecular formula: C24H31F3N4S. Mole weight: 464.6. Appearance: Solid powder. Purity: >98%. IUPACName: N,N-dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine. Canonical SMILES: FC (C (C=C1N2CCCN3CCN (CCN (C)C)CC3)=CC=C1SC4=C2C=CC=C4) (F)F. Catalog: ACM801991877.