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Heterocyclic Organic Compound. CAS No. 111483-93-3. Catalog: ACM111483933.
Uk-1
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities. UK-1 also inhibits HCV replication. Group: Inhibitors. Alternative Names: UK 1. CAS No. 151271-53-3. Molecular formula: C22H14N2O5. Mole weight: 386.362. Appearance: White to off-white solid. Canonical SMILES: O=C (C1=C2N=C (C3=C4N=C (C5=CC=CC=C5O)OC4=CC=C3)OC2=CC=C1)OC. Catalog: ACM151271533.
Ulodesine
Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor in development as a once-daily oral, chronic treatment for gout. Ulodesine is currently being developed by Biocryst. Ulodesine acts upstream of xanthine oxidase in the purine metabolism pathway to reduce the production of serum uric acid (sUA). Ulodesine has an IC(50) of 0.5 nM to PNP. BCX-4208 is currently undergoing early clinical investigation in psoriasis and gout. Group: Inhibitors. Alternative Names: BCX4208, BCX 4208, BCX-4208, Ulodesine, DADMe-immucillin H. CAS No. 548486-59-5. Molecular formula: C12H16N4O3. Mole weight: 264.28. Appearance: Solid powder. Purity: >98%. IUPACName: 7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one. Canonical SMILES: O=C1C (NC=C2CN3C[C@H] (O)[C@@H] (CO)C3)=C2N=CN1. Catalog: ACM548486595.
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP-transgenic mice. Group: Inhibitors. Alternative Names: Umibecestat; CNP-520; CNP 520; CNP520. CAS No. 1387560-01-1. Molecular formula: C19H15ClF7N5O2. Mole weight: 513.8. Appearance: Solid powder. Purity: >98%. IUPACName: N-{6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl}-3-chloro-5- (trifluoromethyl)pyridine-2-carboxamide. Canonical SMILES: O=C (C1=NC=C (C (F) (F)F)C=C1Cl)NC2=NC ([C@]3 (C)CO[C@] (C (F) (F)F) (C)C (N)=N3)=C (F)C=C2. Catalog: ACM1387560011.
UNC6934
UNC6934 is a novel potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 ± 18 nM, being selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1, the closest on the phylogenetic tree, disrupting the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells. Group: Antagonists. Alternative Names: UNC6934; UNC-6934; UNC 6934. CAS No. 2561494-77-5. Molecular formula: C24H21N5O4. Mole weight: 443.46. Appearance: Solid powder. Purity: >98%. IUPACName: N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide. Canonical SMILES: O=C (C1=CC=C (N2)C (OCC2=O)=C1)N (C3CC3)CC4=CC=C (C (NC5=NC=NC=C5)=O)C=C4. Catalog: ACM2561494775.
Aldehydes. Alternative Names: 10-Undecenyl Aldehyde, 10-Undecenal. CAS No. 112-45-8. Molecular formula: C11H20O. Mole weight: 168.28. Canonical SMILES: C=CCCCCCCCCC=O. Catalog: ACM112458-2.
Uranine k
Alfa Chemistry offers Uranine K products for various research purposes. Please contact us by email if you do not find the specification you are looking for on this page. Uses: Applications of xanthene dyes involve optical materials and organic dyes for medical diagnosis research. several characteristic features of xanthene dyes are large absorption and luminescence, excellent light resistance, low toxicity in-vivo, and relatively high solubility in water. Group: Heterocyclic organic compound. Alternative Names: Fluorescein Potassium Salt. CAS No. 6417-85-2. Molecular formula: C20H10K2O5. Mole weight: 408.49. Appearance: Light yellow to Yellow to Orange powder to crystal. Catalog: ACM6417852.
Urea Ammonium Nitrate (UAN) solution, produced by combining urea, nitric acid, and ammonia, is a liquid fertilizer product with a nitrogen content that typically ranges from 28 percent to 32 percent. UAN can be applied more uniformly than non-liquid forms of fertilizer. Uses: It can be mixed with herbicides, pesticides, and other nutrients, enabling farmers to reduce costs by applying several materials simultaneously rather than making several separate applications.solutions of uan are widely used as a source of n for plant nutrition. the no3- portion (25 percent of the total n) is immediately available for plant uptake. the nh4+ fraction (25 percent of the total n) ca. Group: Heterocyclic organic compound. Alternative Names: UAN;Urea ammonium nitrate;azane: nitric acid: urea;Nitrogen solutions (UAN);Nitric acid ammonium salt, mixt. with urea;Urea, mixt. with ammonium nitrate. CAS No. 15978-77-5. Molecular formula: CH6N4O4. Mole weight: 138.08274. Catalog: ACM15978775.
Urea,ethyltrimethyl-(9ci)
Heterocyclic Organic Compound. CAS No. 113502-25-3. Catalog: ACM113502253.
Urolithin A is a urolithin, a type of microflora human metabolite of dietary ellagic acid derivatives, such as ellagitannins.During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo.Urolithin A glucuronide is found in plasma at low concentrations. Group: Inhibitors. Alternative Names: Uro-A;pyran-6-one.html >3,8-Dihydroxy-6H-dibenzopyran-6-one;3,8-dihydroxybenzo[c]chromen-6-one;3,8-Dihydroxyurolithin. CAS No. 1143-70-0. Molecular formula: C13H8O4. Mole weight: 228.2. Appearance: Olive green powder. Purity: 0.98. Density: 1.516 g/cm³. Catalog: ACM1143700.
Ursodeoxycholic acid
Ursodeoxycholic acid (INN, BAN and AAN), also known as ursodiol (USAN) and the abbreviation UDCA, from the root-word for bear urso, as bear bile contains the substance, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Group: Steroidal compounds. Alternative Names: Tauroursodiol. CAS No. 128-13-2. Molecular formula: C24H40O4. Mole weight: 392.57. Appearance: Solid. Purity: 0.98. IUPACName: (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid. Canonical SMILES: CC (CCC (=O)O)C1CCC2C1 (CCC3C2C (CC4C3 (CCC (C4)O)C)O)C. Density: 0.9985 g/cm³. ECNumber: 204-879-3. Catalog: ACM128132.
UUN44923 is a FTO inhibitor. UUN44923 may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS)?, type 2 diabetes (T2D)?, Alzheimer's diseases, breast cancers, small-cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like. UUN44923 was reported in WO 2018157843. Group: Inhibitors. Alternative Names: UUN44923; UUN-44923; UUN 44923; Dac51; Dac-51; Dac 51. CAS No. 2243944-92-3. Molecular formula: C18H16Cl2N4O2. Mole weight: 391.25. Appearance: Solid powder. Purity: >98%. IUPACName: Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy-. Canonical SMILES: O=C (NO)C1=CC=CC=C1NC2=C (Cl)C=C (C3=C (C)NN=C3C)C=C2Cl. Catalog: ACM2243944923.
UV Absorber-UV 1577
UV 1577 is a hydroxyphenyl triazine grade. Acts as a UV absorber. Group: Uv resistant finishing agent. Alternative Names: 2-(4,6-Diphenyl-1,3,5-triazin-2-yl)-5-[(hexyl)oxy]-phenol. CAS No. 147315-50-2. Molecular formula: C27H27N3O2. Mole weight: 425.52. Catalog: ACM147315502.
UV Absorber-UV 1600
UV 1600 is an UV absorber of the hydroxyphenyl triazine class good compatibility with a variety of polymers, co-additives and resin compositions. Group: Uv resistant finishing agent. Alternative Names: 2-hydroxyphenyl-s-triazine derivative. CAS No. 204583-39-1. Molecular formula: C41H39N3O2. Mole weight: 605.77. Catalog: ACM204583391.
UV Absorber-UV 3030
UV 3030 (178671-58-4) is an UV Absorber that can be used to stabilize highly transparent polymers with high extrusion temperatures. Group: Uv resistant finishing agent. Alternative Names: 1, 3-bis-((2-cyano-3, 3-diphenylacryloyl) oxy)-2, 2-bis-(((2-cyano-3, 3-diphenylacryloyl) oxy) methyl)-propane. CAS No. 178671-58-4. Molecular formula: C69H48N4O8. Mole weight: 1061.14. Catalog: ACM178671584-1.
UV Absorber-UV 360
A very low volatile product of hydroxyphenyl benzotriazole class, imparting outstanding light stability to a variety of polymers. Group: Uv resistant finishing agent. Alternative Names: Phenol, 2,2-methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)). CAS No. 103597-45-1. Molecular formula: C41H50N6O2. Mole weight: 658.87. Catalog: ACM103597451.
UV Absorber-UV 3638
Offers very strong and broad UV absorption with no color contribution. Group: Uv resistant finishing agent. Alternative Names: 2,2'-(1,4-phenylene)bis[4H-3,1-benzoxazin-4-one]. CAS No. 18600-59-4. Molecular formula: C22H12N2O4. Mole weight: 368.34. Catalog: ACM18600594.
UV Absorber-UV 384-2
Liquid hydroxyphenyl-benzotriazole. Acts as a UV absorber. Group: Uv resistant finishing agent. Alternative Names: Hydroxyphenyl-benzotriazole. CAS No. 127519-17-9. Molecular formula: C81H111N9O9. Mole weight: 451.61. Catalog: ACM127519179.
UV Absorber-UV 4050
UV 4050 (124172-53-8) acts as a light stabilizer / UV absorber. It is suitable for the stabilization of polyolefins, particularly in thick-walled PP molding and PP fibers, as well as ABS, PS, PA and polyesters. Group: Uv resistant finishing agent. Alternative Names: N, N'-bis(2, 2, 6, 6-tetramethyl-4-piperidyl)-N, N'-diformylhexamethylenediamine. CAS No. 124172-53-8. Molecular formula: C26H50N4O2. Mole weight: 450.7. Catalog: ACM124172538.
UV Absorber-UV 988
UV 988 (6337-43-5) is a benzylidene-bis-malonate type UV absorber. It strongly absorbs in the high energy part of the UV spectrum (short wavelength). Group: Uv resistant finishing agent. Alternative Names: Tetraethyl 2,2-(1,4-phenylenedimethylidyne)bismalonate. CAS No. 6337-43-5. Molecular formula: C22H26O8. Mole weight: 418.437. Catalog: ACM6337435-1.
UV Absorber-UV B 75
UV B 75 is a synergistic blend of 20% AN 1135, 40% UV 571 and 40% LS 292. Acts as a light and heat stabilizer agent. Group: Uv resistant finishing agent. Alternative Names: 2-(2H-Benzothiazol-2-yl)-6-(dodecyl)-4-methylphenol. CAS No. 41556-26-7/82919-37-7. Molecular formula: C30H56N2O4 / C21H39NO4. Mole weight: 508.78 / 369.54. Catalog: ACM41556267-3.
V2AlC MAX Phase Material
V2AlC MAX phase material is a new type of machinable conductive ceramic material that has attracted much attention. The size and process can be customized and can be used to prepare Mxene materials. Uses: Products are mainly used for high temperature coatings, mxene precursors, conductive self-lubricating ceramics, lithium ion batteries, super capacitors, electrochemical catalysis. Group: V2alc max. CAS No. 12176-421-9. Appearance: Light Gray Powder. Purity: 0.99. Catalog: ACM121764219.
Vacuolin-1
Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin-1 is a potent and selective PIKfyve inhibitor and inhibits late-stage autophagy by impairing lysosomal maturation. Group: Inhibitors. CAS No. 351986-85-1. Molecular formula: C26H24IN7O. Mole weight: 577.42. Appearance: Solid. Purity: 0.9893. Canonical SMILES: IC1=CC (/C=N/NC2=NC (N (C3=CC=CC=C3)C4=CC=CC=C4)=NC (N5CCOCC5)=N2)=CC=C1. Catalog: ACM351986851.
Valacyclovir hydrochloride
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422). Group: Inhibitors. Alternative Names: VALACICLOVIR HCL;VALACICLOVIR HYDROCHLORIDE; VALACV; VALACYCLOVIR; VALACYCLOVIR HYDROCHLORIDE;L-VALINE 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9YL)METHOXY]ETHYL ESTER, HYDROCHLORIDE SALT;VALACICLOVIR HCL 99%;VALACICLOVIR HYDROCHLORIDE,98.0+%. CAS No. 124832-27-5. Molecular formula: C13H21ClN6O4. Mole weight: 360.8. Purity: 0.9972. Catalog: ACM124832275.
Valerian Root Extract
Extract obtained from Valerian Officinalis (Valerian) roots. Contains 20% extract dissolved in water and glycerin. Has sooting, calming, and toning properties. Uses: Creams, lotions, masks, and bath care products. Group: Skin actives. CAS No. 7732-18-5/56-81-5/8057-49-6/122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0797.
Valethamate
Valethamate is a pharmaceutical drug that is administered to women for the treatment of urinary incontinence. It is used in combination with pentobarbital sodium and other drugs, such as fatty acids and depressants, to treat urinary incontinence. Valethamate inhibits spontaneous activity in the detrusor muscle by blocking the action of norepinephrine on alpha-adrenergic receptors. This drug has been shown to be clinically effective for treating urinary incontinence in women who have not responded to other treatments. Valethamate has also been shown to cause vessel occlusion when injected into the femoral vein of experimental animals and may increase blood pressure when given intravenously. Group: Other alkaloids. CAS No. 16376-74-2. Molecular formula: C21H21NO6. Mole weight: 383.39 g/mol. Canonical SMILES: CCC (C)C (C1=CC=CC=C1)C (=O)OCC[N+] (C) (CC)CC. Catalog: ACM16376742.
Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.IC50 Value:Target: CMVin vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(I) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases.in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P =.004). Group: Inhibitors. Alternative Names: VALGANCICLOVIR HYDROCHLORIDE;L-VALINE, 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYL ESTER, MONOHYDROCHLORIDE;VALGANCICLOVIR HCL;L-VALINE, 2-[(2-AMINO-1, 6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHO
Heterocyclic Organic Compound. Alternative Names: VANADIUM CARBIDES;Einecs 234-380-6. CAS No. 11130-21-5. Molecular formula: VC. Mole weight: 62.95. Catalog: ACM11130215.
Vanadium(III) oxide
Vanadium trioxide appears as a black crystalline solid. Density 4.87 g / cm³. Slightly soluble in water. Irritating to skin and eyes. May be toxic by ingestion. Used to make other chemicals. Used as a catalyst.;DryPowder;BLACK POWDER. Group: Electrode materialssolid oxide fuel cell materials. CAS No. 1314-34-7. Molecular formula: V2O3;V2O3;O3V2. Mole weight: 149.881g/mol. IUPACName: oxo(oxovanadiooxy)vanadium. Canonical SMILES: O=[V]O[V]=O. Density: 4.87 g/cu cm;4.87 g/cm³. ECNumber: 215-230-9. Catalog: ACM1314347.
Silvery-whitish powder. Resists corrosion.;Liquid; OtherSolid; PelletsLargeCrystals. Group: Pure element single crystals. CAS No. 7440-62-2. Molecular formula: V. Mole weight: 50.941g/mol. Appearance: Silver-Grey. Purity: 99%, 99.5%, 99.9%, 99.95%, 99.99%, 99.999%. IUPACName: vanadium. Canonical SMILES: [V]. Density: Specific gravity: 6.11 at 18.7 °C. ECNumber: 231-171-1. Catalog: ACM7440622.
Vancomycin hydrochloride
Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis. Group: Inhibitors. CAS No. 1404-93-9. Purity: 0.9943. Catalog: ACM1404939.
Vanilla Extract
Extract obtained from Vanilla Planifolia (Vanilla) fruit/seeds. Contains 20% extract dissolved in water and glycerin. Has soothing, calming, toning and emollient properties. Uses: Creams, lotions, and bath care products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84650-63-5 / 122-99-6. Appearance: Light to medium yellow liquid, characteristic odor. Catalog: CI-SC-0841.
Vanillin-13C
Vanillin-13C6 is 13C labeled Vanillin[1]. Vanillin has the aroma of vanilla beans and a rich milky aroma. It plays the role of flavoring and fixative. It is widely used in cosmetics, tobacco, cakes, candies, baked goods and other industries. Group: Isotope-labeled synthetic intermediates. CAS No. 86884-84-6. Molecular formula: C713CH8O3. Mole weight: 153.14. Canonical SMILES: [13CH3]OC1=CC(C=O)=CC=C1O. Catalog: ACM86884846.
Vanillyl Butyl Ether
Vanillyl Butyl Ether is an oil-soluble warming agent. It can induce an enduring and gentle warming sensation on our skin and increase its temperature which speeds up the burning of the subcutaneous fat and makes the body slim. As it is very stable and nontoxic, it has become a good additive to the modern functional body-slimming products. Uses: Vanilly butyl ether is a warming agent, suitable for body slimming products, feet care products and other partial warming products. suitable to emulsion, scream etc. it is suggested that it should not be used for any face or eye products or be used to any part of the body that could be easily stimulated. Group: Heterocyclic organic compound. Alternative Names: Butyl vanillyl ether. CAS No. 82654-98-6. Molecular formula: C12H18O3. Mole weight: 210.27. Appearance: Colorless to yellowish liquid. Purity: 98%+. IUPACName: 4-(Butoxymethyl)-2-methoxyphenol. Canonical SMILES: CCCCOCC1=CC(=C(C=C1)O)OC. Density: 1.057 g/mL at 25 °C(lit.). Catalog: ACM82654986.
VAS3947
VAS3947 is a selective inhibitor of NADPH oxidase activity in low micromolar concentrations, interfering neither with ROS detection nor with XOD or eNOS activities. VAS3947 induces apoptosis in AML cells independently of its anti-NOX activity. VAS3947 thiol alkylates cysteine residues of glutathione (GSH), while also interacting with proteins. Remarkably, VAS3947 decreased detectable GSH in the MV-4-11 cell line, thereby suggesting possible oxidative stress induction. Overall, VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins. Group: Inhibitors. Alternative Names: VA-S3947; VA S3947; VAS3947. CAS No. 869853-70-3. Molecular formula: C14H10N6OS. Mole weight: 310.34. Appearance: Solid powder. Purity: >98%. IUPACName: 3-Benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine. Canonical SMILES: C12=NC=NC (SC3=NC=CO3)=C1N=NN2CC4=CC=CC=C4. Catalog: ACM869853703.
Vat Blue 4
Vat blue 4 appears as blue needles with a metallic luster or fine fluffy deep blue powder. (NTP, 1992);DryPowder, WetSolid; OtherSolid, Liquid. Group: Vat dyes. CAS No. 81-77-6. Molecular formula: C28H14N2O4. Mole weight: 442.4g/mol. Appearance: Blue needles with a metallic lustre. Purity: 0.98. IUPACName: 2, 17-diazaheptacyclo[16.12.0.03, 16.04, 13.06, 11.019, 28.021, 26]triaconta-1(18), 3(16), 4(13), 6, 8, 10, 14, 19(28), 21, 23, 25, 29-dodecaene-5, 12, 20, 27-tetrone. Canonical SMILES: C1=CC=C2C (=C1)C (=O)C3=C (C2=O)C4=C (C=C3)NC5=C (N4)C=CC6=C5C (=O)C7=CC=CC=C7C6=O. Density: 1.487 g/cm³. ECNumber: 201-375-5. Catalog: ACM81776.
Natural vegetable wax blend with hydrophilic properties and oil gelling capabilities designed to be used in all cosmetic and personal care applications. Saponification value 90-110 mgKOH/g. Melting point 60-70°C (140-158°F). Uses: Creams, body butters, hair styling products, hair waxes, lipsticks, liquid lipsticks, and mascaras. Group: Emollients/oils/wax. CAS No. 17671-27-1 / 58128-22-6 / 79777-30-3 / 8006-44-8 / 25383-99-7. Appearance: Off-white to tan prills, odorless. Catalog: CI-SC-0400.
Veratric acid-d6
Veratric acid-d6 is deuterium labeled Veratric acid. Veratric Acid-d6 is deuterium-labeled veratonic acid. Veratric acid is extracted from plants and is mainly used as a chemical reagent. Veratric acid has antioxidant and anti-inflammatory activities. Group: Isotope-labeled synthetic intermediates. Alternative Names: 3,4-Dimethoxybenzoic acid-d6. CAS No. 1162658-12-9. Molecular formula: C9H4D6O4. Mole weight: 188.21. Canonical SMILES: O=C (O)C1=CC=C (OC ([2H]) ([2H])[2H])C (OC ([2H]) ([2H])[2H])=C1. Catalog: ACM1162658129.
Veratrine HCl
Veratrine HCl is a vasoactive intestinal peptide that binds to ganglia and produces whole-body effects. It is an inhibitor of chloride channels, which leads to increased acetylcholine release. Veratrine HCl is a potent competitive antagonist of acetylcholine at muscarinic receptors in the heart and brain, leading to decreased cardiac and serotonin activity. The drug also has a depressant effect on the central nervous system. Veratrine HCl increases the amount of chloride in the blood and expiratory flow by inhibiting choline uptake into cells. It is used as an analytical method for measuring triazine herbicides. Group: Other alkaloids. Alternative Names: N-[(Benzyloxy)Carbonyl]-L-Tyrosyl-L-Valyl-N-[(3S)-5-Fluoro-1-Methoxy-1,4-Dioxo-3-Pentanyl]-L-alaninamide. CAS No. 17666-25-0. Molecular formula: C32H50ClNO9. Mole weight: 628.19 g/mol. Canonical SMILES: C/C=C (/C)\C (=O)O[C@H]1CC[C@]2 ([C@H]3[C@@]1 (O[C@@]24C[C@]5 ([C@@H]6CN7C[C@H] (CC[C@H]7[C@@] ([C@]6 ([C@H] (C[C@]5 ([C@@H]4CC3)O)O)O) (C)O)C)O)O)C. Cl. Catalog: ACM17666250.
Verbascoside
Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity. Group: Inhibitors. Alternative Names: Acteoside. CAS No. 61276-17-3. Molecular formula: C29H36O15. Mole weight: 624.59. Purity: 98%+. IUPACName: Verbascoside. Density: 1.6 g/cm³. Catalog: ACM61276173.
Verrucofortine
Heterocyclic Organic Compound. Alternative Names: Fructigenine B. CAS No. 113706-21-1. Molecular formula: C24H31N3O3. Mole weight: 409.5. Appearance: Pale yellow residue. Purity: 95%+. IUPACName: Verrucofortine. Canonical SMILES: CC (C)CC1C (=O)N2C (CC3 (C2N (C4=CC=CC=C43)C (=O)C)C (C) (C)C=C)C (=O)N1. Density: 1.21g/cm³. Catalog: ACM113706211.
Verteporfin
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation. Group: Inhibitors. Alternative Names: Verteprofin; Verteporphin; trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester; Visudyne; VERTEPORFIN (200 MG). CAS No. 129497-78-5. Molecular formula: C41H42N4O8. Mole weight: 1437.61. Appearance: Powder. Purity: 0.95. IUPACName: Verteporfin. Canonical SMILES: C[C@]1 (/C2=C/C (N3)=C4C)C (C (/C=C (C (C)=C/5C=C)\NC5=C/C6=N/C (C (CCC (OC)=O)=C6C)=C\C3=C4CCC (O)=O)=N2)=CC=C (C (OC)=O)[C@H]1C (OC)=O. C[C@]7 (/C8=C/C (N9)=C%10C)C (C (/C=C (C (C)=C/%11C=C)\NC%11=C/C%12=N/C (C (CCC (O)=O)=C%12C)=C\C9=C%10CCC (OC)=O)=N8)=CC=C (C (OC)=O)[C@H]7C (OC)=O. Catalog: ACM129497785-1.
Verticillatine
Verticillatine is a chemical compound that belongs to the family of biphenyls. It has been found to have anti-inflammatory effects and haemodynamic effects, as well as the ability to reduce blood pressure. Verticillatine has also been shown to reduce pain in anesthetized rats. This may be due to its ability to modulate the body's inflammatory response or its effect on the haemodynamic system (e.g., by affecting vasodilation). The chemical structure of verticillatine is similar to that of other biphenyls, which are used in industrial processes as models for other molecules. Verticillatine has been shown to react with acid catalysts and is capable of forming conjugates with amino acids and sugars. Group: Other alkaloids. CAS No. 10247-54-8. Molecular formula: C25H27NO5. Mole weight: 421.49 g/mol. Canonical SMILES: COc1ccc2[C@@H]3C[C@H] (C[C@H]4CCCCN34)OC (=O)\C=C/c5ccc (O)c (c5)c2c1O. Catalog: ACM10247548.
Verubecestat TFA
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients. Group: Inhibitors. Alternative Names: MK-8931; MK 8931; MK8931; MK-8931-009; SCH 900931; SCH-900931; SCH900931; Verubecestat TFA. CAS No. 2095432-65-6. Molecular formula: C19H18F5N5O5S. Mole weight: 523.44. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide trifluoroacetic acid. Canonical SMILES: O=C (NC1=CC=C (F)C ([C@@] (C2) (C)N=C (N)N (C)S2 (=O)=O)=C1)C3=NC=C (F)C=C3. O=C (O)C (F) (F)F. Catalog: ACM2095432656.
Vidarabine
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2. Vidarabine also has anti-orthopoxvirus activity. Group: Inhibitors. Alternative Names: ARABINOSYL-ADENINE;6-AMINO-9-BETA-D-ARABINOFURANOSYLPURINE;ADENINE-BETA-D-ARABINOFURANOSIDE;ADENINE-9-BETA-D-ARABINOFURANOSIDE;9-BETA-D-ARABINOSYLADENINE;9-BETA-D-ARABINOFURANOSYLADENINE;2-ARAADENOSINE;SPONGOADENOSINE. CAS No. 5536-17-4. Molecular formula: C10H13N5O4. Mole weight: 267.24. Purity: ≥98.0%. Catalog: ACM5536174.
Vildagliptin
Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity. Group: Inhibitors. Alternative Names: Unii-I6B4B2U96p; Laf 237; Galvus. CAS No. 274901-16-5. Molecular formula: C17H25N3O2. Mole weight: 303.4. Appearance: white crystalline powder. Purity: 0.98. IUPACName: (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile. Canonical SMILES: C1CC (N (C1)C (=O)CNC23CC4CC (C2)CC (C4) (C3)O)C#N. Density: 1.27 g/cm³. Catalog: ACM274901165.
Vinblastine sulfate
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM. Group: Inhibitors. Alternative Names: (3S)-3-Phenylisoserine hydrochloride. CAS No. 143-67-9. Molecular formula: C46H60N4O13S. Mole weight: 909.05. Appearance: White powder. Purity: 0.98. IUPACName: Methyl (1R, 9R, 10S, 11R, 12R, 19R)-11-acetyloxy-12-ethyl-4-[(13S, 15S, 17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1, 11-diazatetracyclo[13.3.1.04, 12.05, 10]nonadeca-4(12), 5, 7, 9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8, 16-diazapentacyclo[10.6.1.01, 9.02, 7.016, 19]nonadeca-2, 4, 6, 13-tetraene-10-carboxylate;sulfuric acid. Canonical SMILES: CC[C@@]1 (C[C@@H]2C[C@@] (C3=C (CCN (C2)C1)C4=CC=CC=C4N3) (C5=C (C=C6C (=C5)[C@]78CCN9[C@H]7[C@@] (C=CC9) ([C@H] ([C@@] ([C@@H]8N6C) (C (=O)OC)O)OC (=O)C)CC)OC)C (=O)OC)O. OS (=O) (=O)O. Catalog: ACM143679.
Vindoline, a vinca alkaloid extracted from the leaves of Catharanthus roseus, weakly inhibits tubulin self-assembly. Group: Inhibitors. Alternative Names: (2β,5α,12R,19α)-4β-(Acetyloxy)-6,7-didehydro-3β-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester. CAS No. 2182-14-1. Molecular formula: C25H32N2O6. Mole weight: 456.5. Appearance: Solid. Purity: 98%+. Canonical SMILES: CC[C@@]1 (C=CCN2CC3)[C@@]2 ([H])[C@@]3 (C4=CC=C (OC)C=C4N5C)[C@]5 ([H])[C@] (C (OC)=O) (O)[C@@H]1OC (C)=O. Catalog: ACM2182141.
Vinflunine
Vinflunine is an antitumor agent that inhibits the mitochondrial membrane potential, resulting in the breakdown of intracellular ATP and cell death. Vinflunine has been shown to be effective against a number of carcinoma cell lines, including those from solid tumours (e.g., breast cancer) and those from blood cells (e.g., leukemia). Vinflunine has also been shown to be effective against angiogenic processes in vitro assays and in vivo trials. Vinflunine is active against natural compounds such as p-hydroxybenzoic acid, which are involved in the production of collagen and other proteins essential for tumor growth. In addition, vinflunine has been shown to cause significant cytotoxicity against tumors in vivo. Group: Other alkaloids. CAS No. 162652-95-1. Canonical SMILES: CC[C@@]12C=CCN3[C@H]1[C@]4 (CC3)[C@@H] ([C@] (C2OC (=O)C) (C (=O)OC)O)N (C5=CC (=C (C=C45)[C@]6 (CC7CC (CN (C7)CC8=C6NC9=CC=CC=C89)C (C) (F)F)C (=O)OC)OC)C. Catalog: ACM162652951.
Vinflunine ditartrate
Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast. Group: Inhibitors. Alternative Names: 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate; 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate; BMS 710485; F 12158; Javlor. CAS No. 194468-36-5. Molecular formula: C53H66F2N4O20. Mole weight: 1117.1. Appearance: White Solid. Canonical SMILES: OC ([C@H] (O)[C@@H] (O)C (O)=O)=O. OC ([C@H] (O)[C@@H] (O)C (O)=O)=O. CC[C@@]1 (C=CCN2CC3)[C@@]2 ([H])[C@@]3 (C (C=C ([C@] (C4=C5C (C=CC=C6)=C6N4) (CC (C[C@@H] (C (F) (F)C)C7) ([H])CN7C5)C (OC)=O)C (OC)=C8)=C8N9C)[C@]9 ([H])[C@] (C (OC)=O) (O)[C@@H]1OC (C)=O. Catalog: ACM194468365.