BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Rp-2'-AHC-cAMPS-Agarose | Rp-2'-AHC-cAMPS-Agarose is the PDE-resistant protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. |  |
| Rp-2'-AHC-cGMPS | Rp-2'-AHC-cGMPS is a PDE-stable cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C17H26N7O7PS. Mole weight: 503.5. | |
| Rp-2'-AHC-cGMPS-Agarose | Rp-2'-AHC-cGMPS-Agarose is the PDE-resistant PKG inhibitor Rp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
| Rp-2-Cl-cAMPS | Rp-2-Cl-cAMPS is an analogue of Rp-cAMPS, the protein kinase A inhibitor. The chlorine atom in position 2 of adenine nucleobase significantly increase the stability and lipophilicity. Synonyms: 2- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 124844-92-4. Molecular formula: C10H10ClN5O5PS · Na. Mole weight: 401.7. | |
| Rp-2'-O-Me-CTP-α-S | Rp-2'-O-Me-CTP-α-S is a phosphorothioate analogue of CTP. Synonyms: 2'-O-Methylcytidine-5'-O- (1-thiotriphosphate), Rp-isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 143028-95-9. Molecular formula: C10H18N3O13P3S (free acid). Mole weight: 513.3 (free acid). | |
| Rp-2'-O-Me-GTP-α-S | Rp-2'-O-Me-GTP-α-S is a phosphorothioate analogue of GTP. Synonyms: 2'-O-Methylguanosine-5'-O-(1-thiotriphosphate), Rp-isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 143028-96-0. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). | |
| Rp-6-Cl-cPuMPS | Rp-6-Cl-cPuMPS is a PDE-resistant modulator of protein kinase A that can be modified in position 6. Synonyms: 6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 129693-15-8. Molecular formula: C10H9ClN4O5PS · Na. Mole weight: 386.7. | |
| Rp-8-AEA-cAMPS | Rp-8-AEA-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores and other markers. Synonyms: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer. Grades: ≥ 98% by HPLC. CAS No. 221904-78-5. Molecular formula: C12H18N7O5PS. Mole weight: 403.4. | |
| Rp-8-AEA-cAMPS-Agarose | Rp-8-AEA-cAMPS-Agarose is the metabolically stable protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinase A (presumably as its holoenzyme), phosphodiesterases and others. Synonyms: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel. | |
| Rp-8-AET-cGMPS | Rp-8-AET-cGMPS is a ligand in affinity chromatography and can be modified with fluorophores or other markers. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer. Grades: ≥ 98% by HPLC. CAS No. 221904-88-7. Molecular formula: C12H17N6O6PS2. Mole weight: 436.4. | |
| Rp-8-AET-cGMPS-Agarose | Rp-8-AET-cGMPS-Agarose is the metabolically stable protein kinase G inhibitor Rp-cGMPS immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
| Rp-8-AHA-cAMPS-Agarose | Rp-8-AHA-cAMPS-Agarose is the metabolically stable protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinase A (presumably as its holoenzyme), phosphodiesterases and others. Synonyms: 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
| Rp-8-Br-cAMPS | Rp-8-Br-cAMPS is an analogue of the cAMP with a preference for type I of protein kinase A. Compared to Rp-cAMPS, it has more lipophilic and membrane-permeant properties. Rp-8-Br-cAMPS effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 129735-00-8. Molecular formula: C10H10BrN5O5PS · Na. Mole weight: 446.2. | |
| Rp-8-Br-cGMPS | Rp-8-Br-cGMPS is an inhibitor of protein kinase G I α and I ß. It effects against mammalian cyclic nucleotide- dependent phosphodiesterases. Compared to cGMP or Rp-cGMPS, it has more lipophilic and membrane-permeant properties. Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 150418-07-8. Molecular formula: C10H10BrN5O6PS · Na. Mole weight: 462.2. | |
| Rp-8-Br-PET-cGMPS | Rp-8-Br-PET-cGMPS is a selective inhibitor of cGMP-dependent protein kinase I a and I β and of retinal cGMP-gated ion channels. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-8-pCPT-cGMPS, it is much more lipophilic and membrane-permeant. Synonyms: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-20-1. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
| Rp-8-Cl-cAMPS | Rp-8-Cl-cAMPS is a selective and competitive inhibitor of protein kinase A (cAMP antagonist) preferring type I of protein kinase A. It inhibits mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Chloroadenosine- 3', 5'- monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 142754-27-6. Molecular formula: C10H10ClN5O5PS · Na. Mole weight: 401.7. | |
| Rp-8-CPT-cAMPS | Rp-8-CPT-cAMPS is an analog of Rp-cAMPS and a competitive inhibitor of protein kinase A type I and II (cAMP antagonist). It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-8-Br-cAMPS, it is more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 129735-01-9. Molecular formula: C16H14ClN5O5PS2 · Na. Mole weight: 509.8. | |
| Rp-8-OH-cAMPS | Rp-8-OH-cAMPS is a polar analogue of Rp-cAMPS, the protein kinase A inhibitor, used for the study of extracellular cAMP receptors. It inhibits mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Hydroxyadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 475084-30-1. Molecular formula: C10H11N5O6PS · Na. Mole weight: 383.3. | |
| Rp-8-pCPT-PET-cGMPS | Rp-8-pCPT-PET-cGMPS is an inhibitor of protein kinase G and probably of retinal cGMP-gated ion channels. It has a resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- (4- Chlorophenylthio)-β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 1262749-62-1. Molecular formula: C24H18ClN5O6PS2 · Na. Mole weight: 626. | |
| Rp-8-PIP-cAMPS | Rp-8-PIP-cAMPS is a selective analogue of Rp-cAMPS, the protein kinase A inhibitor, preferring site B of cAK type II. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-cAMPS, it has more lipophilic and membrane-permeant properties. Synonyms: 8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 156816-36-3. Molecular formula: C15H20N6O5PS · Na. Mole weight: 450.4. | |
| Rp-c-diAMPS | Rp-c-diAMPS is an analogue of c-diAMP, the bacterial second messenger. Synonyms: Cyclic diadenosine monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H24N10O11P2S (free acid). Mole weight: 674.5 (free acid). | |
| Rp-c-diGMPS | Rp-c-diGMPS is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions. Synonyms: Cyclic diguanosine monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1259875-32-5. Molecular formula: C20H24N10O13P2S (free acid). Mole weight: 706.5 (free acid). | |
| Rp,Rp-c-diAMPSS | Rp,Rp-c-diAMPSS is an analogue of c-diAMP, the bacterial second messenger, which has higher stability. It can be used to study ligand-receptor interactions and to increase the anti-tumor activity of therapeutic vaccines. Synonyms: Cyclic diadenosine monophosphorodithioate, Rp- isomers, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H24N10O10P2S2 (free acid). Mole weight: 690.6 (free acid). | |
| Rp,Rp-c-diGMPSS | Rp,Rp-c-diGMPSS is an analogue of c-diGMP, the bacterial second messenger, with improved stability. It can be used to study ligand-receptor interactions. Synonyms: Cyclic diguanosine monophosphorodithioate, Rp- isomers, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1259875-41-6. Molecular formula: C20H24N10O12P2S2 (free acid). Mole weight: 722.6 (free acid). | |
| Rp,Sp-c-diAMPSS | Rp,Sp-c-diAMPSS is an analogue of c-diAMP, the bacterial second messenger, which has higher stability. It can be used to study ligand-receptor interactions. Synonyms: Cyclic diadenosine monophosphorodithioate, Rp- / Sp- isomers, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H24N10O10P2S2 (free acid). Mole weight: 690.6 (free acid). | |
| Rp,Sp-c-diGMPSS | Rp,Sp-c-diGMPSS is an analogue of c-diGMP, the bacterial second messenger, with improved stability. It can be used to study ligand-receptor interactions. Synonyms: Cyclic diguanosine monophosphorodithioate, Rp- / Sp- isomers, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1259875-47-2. Molecular formula: C20H24N10O12P2S2 (free acid). Mole weight: 722.6 (free acid). | |
| Rp-TTP-α-S | Rp-TTP-α-S is used for regulation of TTP-responsive receptors and determination of their stereospecificity. Compared to TTP, it is much more stable. Synonyms: Thymidine- 5'- O- (1-thiotriphosphate), Rp-isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 83199-35-3. Molecular formula: C10H17N2O13P3S (free acid). Mole weight: 498.2 (free acid). | |
| RSPACER CEP | RSPACER CEP is a biomedical product designed to study Chronic Exertional Compartment Syndrome. Synonyms: 5'-O-Dimethoxytrityl-1'-Deoxyribose-2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; rSpacer TBDMS CE Phosphoramidite. Grades: 95%. CAS No. 159299-31-7. Molecular formula: C41H59N2O7PSi. Mole weight: 750.99. | |
| S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine | S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine, a nucleoside analog, possesses the capability to prevent the replication of hepatitis C virus (HCV) and can assist in curing liver diseases. With clinical trials recording promising results, this biomedical product shows great potential as a therapy for chronic HCV infections. Synonyms: 2-Amino-6-[(2-hydroxy-5-nitrobenzyl)thio]-9-(b-D-ribofuranosyl)purine; S-(2-Hydroxy-5-nitrobenzoyl)-6-thio-D-guanosine; 2-hydroxy-5-nitrobenzylthioguanosine; HNBTG; Hydroxynitrobenzoylthioguanosine; (2R,3R,4S,5R)-2-[2-amino-6-[(2-hydroxy-5-nitrophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol. Grades: ≥ 90%. CAS No. 41094-07-9. Molecular formula: C17H18N6O7S. Mole weight: 450.43. | |
| S-(2-Hydroxy-5-nitrobenzoyl)-6-thioinosine | S-(2-Hydroxy-5-nitrobenzoyl)-6-thioinosine is an antiviral compound, finding immense application in studying chronic viral infections such as herpesvirus and hepatitis B virus. Synonyms: 6-[(2-Hydroxy-5-nitrobenzyl)thio]-9-b-D-ribofuranosylpurine; S-(2-Hydroxy-5-nitrobenzoyl)-6-thio-D-inosine; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[(2-hydroxy-5-nitrophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol; 6-{[(2-Hydroxy-5-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine; (2R,3R,4S,5R)-2-(6-((2-Hydroxy-5-nitrobenzyl)thio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Grades: 97%. CAS No. 56964-73-9. Molecular formula: C17H17N5O7S. Mole weight: 435.41. | |
| S4-(2-Cyanoethyl)-4-thiothymidine | S4-(2-Cyanoethyl)-4-thiothymidine is a groundbreaking and commendable compound, standing as an extraordinary antiviral warrior in studying the nefarious onslaught of viral infections, specifically those engendered by the malevolent DNA viruses. Synonyms: S4-(2-CYANOETHYL)-4-THIOTHYMIDINE. Grades: 95%. CAS No. 869355-26-0. Molecular formula: C13H17N3O4S. Mole weight: 311.36. | |
| S4-(2-Cyanoethyl)-5'-O-(dimethoxytrityl)-4-thiothymidine | S4-(2-Cyanoethyl)-5'-O-(dimethoxytrityl)-4-thiothymidine is a potent biomedical compound used in the research of virus diseases like HIV and herpes simplex virus. This compound acts as a thio-substituted thymidine analogue, inhibiting viral replication and promoting host immune response. Synonyms: S4-(2-CYANOETHYL)-5'-O-(DIMETHOXYTRITYL)-4-THIOTHYMIDINE; S4-(2-CYANOETHYL)-5'-O-(DMT)-4-THIOTHYMIDINE. Grades: 95%. CAS No. 142409-74-3. Molecular formula: C34H35N3O6S. Mole weight: 613.74. | |
| S-(4-Nitrobenzyl)-6-thioguanosine | S-(4-Nitrobenzyl)-6-thioguanosine, an influential biomedical compound widely employed in the management of specific ailments, showcases an enticing potential. Its remarkable aptitude for precisely targeting and impeding viral DNA replication has unveiled auspicious outcomes within viral infection therapy. Moreover, a gamut of viral diseases has succumbed to its efficacious nature, rendering it an invaluable asset in the realm of biomedicine. Synonyms: 2-Amino-6-[(4-nitrobenzyl)thio]-9-b-D-ribofuranosylpurine; NBTGR; S-(P-NITROBENZYL)-6-THIOGUANOSINE; 6-(4-nitrobenzylthio)guanosine; S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN; (2R,3R,4S,5R)-2-[2-amino-6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol. Grades: ≥ 98%. CAS No. 13153-27-0. Molecular formula: C17H18N6O6S. Mole weight: 434.43. | |
| (S)-9-(2,3-Dihydroxypropyl)-2-amino-6-chloropurine | (S)-9-(2,3-Dihydroxypropyl)-2-amino-6-chloropurine, a chemical compound commonly used in the biomedical industry, demonstrates the potential to impede viral DNA synthesis, rendering it a likely antiviral agent. Synonyms: (S)-3-(2-Amino-6-chloro-purin-9-yl)-propane-1,2-diol. Grades: ≥95%. CAS No. 885322-01-1. Molecular formula: C8H10ClN5O2. Mole weight: 243.65. | |
| (S)-9-(2,3-Dihydroxypropyl)-guanine | (S)-9-(2,3-Dihydroxypropyl)-guanine, a pharmaceutical intermediate essential in the synthesis of Acyclovir, an antiviral drug used to combat a variety of viruses. This remarkable molecule showcases its ability to inhibit viral DNA replication, thereby shortening the duration of infections. It is one of the most potent antiviral agents currently available in the market and has been extensively researched and studied to successfully treat and alleviate viral infections. Synonyms: 9-(S)-(2,3-dihydroxypropyl)guanine; 6H-Purin-6-one, 2-amino-9-[(2S)-2,3-dihydroxypropyl]-1,9-dihydro-; (S)-2-amino-9-(2,3-dihydroxypropyl)-1,9-dihydro-6H-purin-6-one; 1-Deoxy-1-(2-amino-6-oxo-1,6-dihydro-9H-purine-9-yl)-D-glycerol. Grades: ≥95%. CAS No. 117143-84-7. Molecular formula: C8H11N5O3. Mole weight: 225.20. | |
| (S)-9-[3-(4,4'-Dimethoxytrityloxy)-2-hydroxypropyl]-N2-isobutyrylguanine | (S)-9-[3-(4,4'-Dimethoxytrityloxy)-2-hydroxypropyl]-N2-isobutyrylguanine, a chemical employed in the realm of biomedicine, is of prime utility for combating viral infections by thwarting viral replication. Herpes simplex and varicella-zoster, among other viruses, fall under its ambit. As a reference standard, it is widely deployed to scrutinize the antiviral potential of nucleoside analogs. Synonyms: Propanamide, N-[9-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-hydroxypropyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-; N-(9-{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide. Grades: ≥95%. CAS No. 182625-67-8. Molecular formula: C33H35N5O6. Mole weight: 597.66. | |
| SAENTA | A novel ligand with high affinity for polypeptides associated with nucleoside transport. Uses: A novel ligand with high affinity for polypeptides associated with nucleoside transport. Synonyms: 5'-S-(2-Aminoethyl)-N6-[(4-nitrobenzyl)-5'-thioadenosine; 5'-S-(2-Aminoethyl)-N-[(4-nitrophenyl)methyl]-5'-thio-adenosine. Grades: 96%. CAS No. 130117-76-9. Molecular formula: C19H23N7O5S. Mole weight: 461.5. | |
| SAICAR | SAICAR is an intermediate in the de novo purine nucleotide synthesis pathway. It depresses the release of several excitatory transmitters and causes direct hyperpolarization of neurons. Synonyms: Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate; (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid. Grades: ≥98%. CAS No. 3031-95-6. Molecular formula: C13H19N4O12P. Mole weight: 454.3. | |
| Sangivamycin | Sangivamycin is a nucleoside (purine) antibiotic produced by the strain of Str. rimosus BA-90912. 0.02-0.05 μg/mL of Sangivamycin inhibits HeLa cells. It has weak inhibitory effect on sarcoma-180 and adenocarcinoma 755 in mice. It has obvious inhibitory effect on leukemia L-1210. When intraperitoneally administered, the drug binds to nucleic acids in tissues in mice through phosphorylation. Uses: Antibiotics, antineoplastic. Synonyms: 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide; 7-Deazaadenosine-7-carboxamide; NSC 65346; Antibiotic B-14437; Ara-sangivamycin. Grades: 95%. CAS No. 18417-89-5. Molecular formula: C12H15N5O5. Mole weight: 309.28. | |
| Sapacitabine | Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. Synonyms: CS682; CYC682; CYC-682; Sapacitabine. CAS No. 151823-14-2. Molecular formula: C26H42N4O5. Mole weight: 490.645. | |
| (S)-DMT-glycidol-A(Bz) | (S)-DMT-glycidol-A(Bz), a critical element in the creation of potential anticancer drugs, has proven effective by restraining tumor progression and stimulating apoptosis in different cancer cell lines such as those in the breast, lung, and pancreas. Its dynamic efficacy in inhibiting specific enzyme pathways at the core of cancer cell growth and survival establish it as a highly viable candidate for innovative cancer treatment measures with significant potential. Synonyms: Benzamide, N-[9-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-hydroxypropyl]-9H-purin-6-yl]-; (S)-9-[3-(4,4'-Dimethoxytrityloxy)-2-hydroxypropyl]-N6-benzoyladenine; 3'-O-Bis(p-methoxyphenyl)phenylmethyl-9-(S)-(2,3-dihydroxypropyl)-N6-benzoyladenine; (S)-N-(9-(3-(Bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropyl)-9h-purin-6-yl)benzamide. Grades: ≥95%. CAS No. 115196-70-8. Molecular formula: C36H33N5O5. Mole weight: 615.68. | |
| (S)-DMT-glycidol-C(Bz) | (S)-DMT-glycidol-C(Bz), a vital pharmaceutical intermediate, finds its usage in the synthesis of an array of drugs. It is particularly deployed in antineoplastic agent formulations such as taxanes and camptothecin analogues. The role of (S)-DMT-glycidol-C(Bz) cannot be understated as it plays a crucial role in the production of drugs catering to cancer and curing other diseases. Synonyms: (S)-1-[3-(4,4'-Dimethoxytrityloxy)-2-hydroxypropyl]-N4-benzoylcytosine. Grades: ≥95%. CAS No. 127757-40-8. Molecular formula: C35H33N3O6. Mole weight: 591.65. | |
| (S)-DMT-glycidol-T | (S)-DMT-glycidol-T is a potent biomedicine utilized to research various diseases. It demonstrates promising antimicrobial activity against multiple drug-resistant bacteria, making it a valuable compound for combating infections. Synonyms: (S)-1-[3-(4,4'-Dimethoxytrityloxy)-2-hydroxypropyl]thymine; (S)-1-(3-(Bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxypropyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-{(2S)-3-[Bis(4-methoxyphenyl)(phenyl)methoxy]-2-hydroxypropyl}-5-methyl-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 168332-12-5. Molecular formula: C29H30N2O6. Mole weight: 502.56. | |
| (S)-DMT-glycidol-uracil | (S)-DMT-glycidol-uracil, an emerging biomedicine, exhibits promising prospects in combatting specific cancer types such as ovarian and endometrial cancer via the inhibition of cancerous cells and induction of apoptosis. Its specificity towards cancer cells significantly reduces the likelihood of injuring healthy cells, making it a viable alternative for cancer treatment. Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-hydroxypropyl]-; (S)-1-[3-(4,4'-Dimethoxy trityloxy)-2-hydroxypropyl]uracil; 1-{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-1H-pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 494784-12-2. Molecular formula: C28H28N2O6. Mole weight: 488.53. | |
| S-Ethyl-CoA | S-Ethyl-CoA is a crucial molecule involved in various metabolic pathways acting as a coenzyme required for the biosynthesis of essential biomolecules, including lipids and amino acids. S-Ethyl-CoA is vital for the production of acetylcholine, playing a crucial role in neurological processes. Synonyms: S-Ethyl-Coenzym A, Sodium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C23H40N7O16P3S (free acid). Mole weight: 795.58 (free acid). | |
| (S)-GNA-C(Bz)-phosphoramidite | Cas No. 885322-06-5. | |
| (S)-GNA-G(iBu)phosphoramidite | Cas No. 182625-68-9. | |
| (S)-GNA-T-phosphoramidite | Cas No. 168332-13-6. | |
| Showdomycin | Showdomycin is a nucleoside antibiotic produced by the strain of Str. showdoensis Z-452. It has anti-bacterial effect. 5-15 mg/(kg.d) of Showdomycin can inhibit Ehrlich ascites cancer. It is also cytotoxic to HeLa cells. Uses: Antibiotics, antineoplastic. Synonyms: D-Showdomycin; 2-beta-D-Ribofuranosylmaleimide; NSC 93047; 3-beta-D-Ribofuranosyl-1H-pyrrole-2,5-dione; Maleimide, 2-b-D-ribofuranosyl-; (+)-Showdomycin; D-(+)-Showdomycin. Grades: ≥ 97%. CAS No. 16755-07-0. Molecular formula: C9H11NO6. Mole weight: 229.19. | |
| Sinefungin | It is a nucleoside antibiotic produced by the strain of Streptomyces griseolus (NRRL 3739). It has the effect against plant pathogenic fungi, candida, Pasteur's yeast and trypanosome. It mainly has the effect against fungal, especially has the strong effect to the Yeast. LD50 is greater than 400 mg/kg. Uses: Antimalarials. Synonyms: Antibiotic A 9145; A 9145; Antibiotic RP 32232; Sinefungina; Sinefungine; Sinefunginum; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid. Grades: >95% by HPLC. CAS No. 58944-73-3. Molecular formula: C15H23N7O5. Mole weight: 381.39. | |
| Sonedenoson | Sonedenoson is an adenosine A2 receptor agonist under the development of King Pharmaceuticals Research and Development. It can effectively promote rapid wound healing. By stimulating adenosine A2 receptor, Sonedenoson can increase angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. In Feb 2008, Sonedenoson was still in Phase II trials for wound healing in the United States, and treatment for Diabetic foot ulcer was discontinued. Uses: Diabetic foot ulcer;wound healing. Synonyms: MRE0094; MRE-0094; MRE 0094; Sonedenoson ;(2R,3R,4S,5R)-2-(6-amino-2-(4-chlorophenethoxy)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Grades: 95%. CAS No. 131865-88-8. Molecular formula: C18H20ClN5O5. Mole weight: 421.83. | |
| Sp-2',3'-cAMPS | Sp-2',3'-cAMPS is a crucial cyclic nucleotide analog acting as an activator of protein kinase A (PKA), enabling the study of its role in signal transduction pathways. This product is widely used in biomedical field research to investigate the modulation of PKA activity and its implications in various drug responses and diseases involving cAMP-dependent signaling pathways. Synonyms: Adenosine- 2', 3'- cyclic monophosphorothioate, exo / Sp- isomer, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 118276-00-9. Molecular formula: C10H11N5O5PS · Na. Mole weight: 367.3. | |
| Sp-2-AEA-cAMPS | Sp-2-AEA-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores and other markers. Synonyms: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C12H18N7O5PS. Mole weight: 403.4. | |
| Sp-2-AEA-cAMPS-Agarose | Sp-2-AEA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose. | |
| Sp-2'-AEC-cAMPS | Sp-2'-AEC-cAMPS is a phosphodiesterase-resistant ligand in affinity chromatography of cAMP and cGMP binding proteins and can be modified with fluorophores and other markers. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C13H18N7O6PS. Mole weight: 431.4. | |
| Sp-2'-AEC-cAMPS-Agarose | Sp-2'-AEC-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel. | |
| Sp-2-AHA-cAMPS-Agarose | Sp-2-AHA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-2'-AHC-cAMPS | Sp-2'-AHC-cAMPS is a PDE-stable analogue of cAMP used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- (6- Aminohexyl)carbamoyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C17H26N7O6PS. Mole weight: 487.5. | |
| Sp-2'-AHC-cAMPS-Agarose | Sp-2'-AHC-cAMPS-Agarose is the PDE-resistant protein kinase A activator Sp-cAMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-2'-AHC-cGMPS | Sp-2'-AHC-cGMPS is a PDE-stable cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Synonyms: 2'- (6- Aminohexyl)carbamoylguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 1262749-61-0. Molecular formula: C17H26N7O7PS. Mole weight: 503.5. | |
| Sp-2'-AHC-cGMPS-Agarose | Sp-2'-AHC-cGMPS-Agarose is the PDE-resistant PKG activator Sp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-2-CF3-cBIMPS | Sp-2-CF3-cBIMPS, a research chemical focused on insulin and glucose metabolism, has potential therapeutic benefits for metabolic diseases like diabetes. By activating the AMP-activated protein kinase (AMPK) pathway, it shows that adding a trifluoromethyl group can increase its potency compared to other AMPK activators. With its documented scientific profile, Sp-2-CF3-cBIMPS embodies a unique approach to metabolism research to inspire medical advancements. Synonyms: 2- Trifluoromethyl- 1- β- D- ribofuranosylbenzimidazole- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Molecular formula: C13H11F3N2O5PS · Na. Mole weight: 418.3. | |
| Sp-2-Cl-cAMPS | Sp-2-Cl-cAMPS is an analogue of Sp-cAMPS, the protein kinase A stimulator. The chlorine atom in position 2 of adenine nucleobase significantly increase the stability and lipophilicity. Synonyms: 2- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 124854-63-3. Molecular formula: C10H10ClN5O5PS · Na. Mole weight: 401.7. | |
| Sp-2'-O-Me-CTP-α-S | Sp-2'-O-Me-CTP-α-S is a CTP analogue that can be used for enzymatic introduction of phosphorothioate and modified 2'-OH groups into RNA. Synonyms: 2'- O- Methylcytidine- 5'- O- (1- thiotriphosphate), Sp- isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 143029-01-0. Molecular formula: C10H18N3O13P3S (free acid). Mole weight: 513.3 (free acid). | |
| Sp-2'-O-Me-GTP-α-S | Sp-2'-O-Me-GTP-α-S is an analogue of GTP that can be used for enzymatic introduction of phosphorothioate and modified 2'-OH groups into RNA. Synonyms: 2'- O- Methylguanosine- 5'- O- (1- thiotriphosphate), Sp- isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 143029-02-1. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). | |
| Sp-6-AE-cAMPS | Sp-6-AE-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It can be modified with fluorophores and other markers. Grades: ≥ 98% by HPLC. Molecular formula: C12H17N6O5PS. Mole weight: 388.4. | |
| Sp-6-AE-cAMPS-Agarose | Sp-6-AE-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
| Sp-6-AH-cAMPS | Sp-6-AH-cAMPS is a phosphodiesterase-resistant ligand in affinity chromatography of cAMP and cGMP binding proteins and can be modified with fluorophores and other markers. Grades: ≥ 98% by HPLC. Molecular formula: C16H25N6O5PS. Mole weight: 444.5. | |
| Sp-6-AH-cAMPS-Agarose | Sp-6-AH-cAMPS-Agarose is the Sp-cAMPS immobilized on agarose by an aminohexyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
| Sp-6-Cl-cPuMPS | Sp-6-Cl-cPuMPS is a PDE-resistant activator of protein kinase A that can be modified in position 6. Synonyms: 6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 129693-12-5. Molecular formula: C10H9ClN4O5PS · Na. Mole weight: 386.7. | |
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