Offer over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, and novel life-science kits for scientific use.
The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery and synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening. Uses: Scientific use. Product Category: L9411. Categories: Cysteine Covalent Libraries.
Cytokine Inhibitor Library
A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed; - Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3600. Categories: Cytokine Inhibitor Libraries.
Cytoskeletal Signaling Pathway Compound Library
A unique collection of 590 cytoskeleton-related compounds, can be used for HTS and HCS?. Uses: Scientific use. Product Category: L1310. Categories: Cytoskeletal Signaling Pathway Compounds Libraries.
Quantity: well-chosen 667 compounds with unique structures targeting DNA damage & repair; - High bioactivity: All compounds with IC50 below 3 μM; - Targets included 19 DNA damage & repair related proteins; - Detailed information: each compound has information about activity testing method, providing reference for your experimental design; - HNMR/LCMS validated to ensure high purity and quality; - A powerful tool for DNA damage/repair targeting drug development and target identification. Uses: Scientific use. Product Category: L3980. Categories: DNA Damage and Repair Compounds Libraries Plus.
DNA Damage & Repair Compound Library
A unique collection of 937 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS); - Targets include HDAC, DNA/RNA synthesis, Topoisomerase, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3900. Categories: DNA Damage & Repair Compounds Libraries.
Quantity: 1159 drug fragments?a must-have tool for FBDD; - Physiochemical properties: 53% of fragments are Ro3 compliant?and all fragments matching with approved drugs or clinical compounds will have the best drug potential; - Quality guaranteed: NMR and HPLC/LCMS validated to ensure high purity and quality; - Applicable to various detection methods: suitable for SPR, NMR, and X-ray crystallization screening. Uses: Scientific use. Product Category: L8800. Categories: Drug-Fragment Libraries.
Drug-induced Liver Injury (DILI) Compound Library
A unique collection of 1040 hepatotoxicity causing compounds, a powerful tool for drug toxicity study, can be used for HTS and HCS screening?- Include anti-cancer drugs, antibiotics, antituberculotic agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc. ?- Diversified in toxicities: Steatosis, Mitochondrial toxicity, cholestasis, drug allergy (hypersensitivity), etc. ; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5510. Categories: Drug-induced Liver Injury (DILI) Compounds Libraries.
Drug Metabolite/Impurity Library
A unique collection of 200 drug isomers/metabolites for high throughput screening (HTS) and high content screening (HCS); - Structurally diverse, medicinally active, and cell permeable; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5800. Categories: Drug Metabolite/Impurity Libraries.
Drug Repurposing Compound Library
A unique collection of 4240 approved and clinical drugs for high throughput screening (HTS) and high content screening (HCS); - An effective tool for discovering new with old drugs, cell induction, and new drug target screening; - All approved drugs collected in this library are approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), or included in the US Pharmacopeia (USP) Dictionary, the British Pharmacopoeia (BP), the European Pharmacopoeia (EP), the Japanese Pharmacopoeia (JP), or Chinese Pharmacopoeia (CP) Dictionary; - Covers various research areas, such as cancer, cardiovascular disease, immunology, respiratory system, etc. - Covers various targets, such as 5-HT Receptor, Sodium Channel, p38 MAPK, PI3K, MEK, etc. - Detailed compound information with structure, target, activity, and brief introduction; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L9200. Categories: Drug Repurposing Compounds Libraries.
A unique collection of 813 compounds targeting endocrine system for high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Estrogen receptor, thyroid hormone receptor, Adrenergic receptors, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2400. Categories: Endocrinology-Hormone Libraries.
Endoplasmic Reticulum Stress Compound Library
A unique collection of 155 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS). Uses: Scientific use. Product Category: L9700. Categories: Endoplasmic Reticulum Stress Compounds Libraries.
Epigenetics Compound Library
Quantity: well-chosen 960 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Targets include HDAC, SIRT, HAT, and HMT, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description, providing reference for your experimental design; - NMR and LCMS/HPLC validated to ensure high purity and quality. - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1200. Categories: Epigenetics Compounds Libraries.
54 exosome-related compounds that can be used for high-throughput and high-content screening. - Can inhibit or activate the secretion or synthesis of exosomes- Detailed instructions, compound structures, target information, activity descriptions, etc. - NMR and HPLC analytical techniques to ensure high product purity and quality. - All compounds are available in stock. Uses: Scientific use. Product Category: L9420. Categories: Exosome Compounds Libraries.
A unique collection of 1729 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS); - Bioactivity and safety confirmed by pre-clinical research evidence and clinical trials; - An effective tool for discovering new with old drugs and new drug target identification; - Covers various research areas: oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc- Structurally diverse, medicinally active, and cell permeable; - Rich documentation with structure, target, IC50 value and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity. Uses: Scientific use. Product Category: L4200. Categories: FDA-Approved Drug Libraries.
FDA-Approved Kinase Inhibitor Library
A unique collection of 280 kinase inhibitors for specific targeting of kinases, ready for high-throughput screening and high-content screening. - All compounds have undergone preclinical studies and clinical trials, approved for marketing by FDA, EMA, PMDA, etc. , with proven biological activity and safety. - Detailed instructions, compound structures, target information, IC50 values, activity descriptions, etc. - NMR, HPLC/LCMS and other assay techniques to ensure the correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L1610. Categories: FDA-Approved Kinase Inhibitor Libraries.
FDA-Approved & Pharmacopeia Drug Library
3158 compounds from marketed drugs for high throughput screening (HTS) and high content screening (HCS); - All compounds collected in this library are drugs approved by FDA, EMA, PMDA, NMPA, etc. or included in pharmacopoeia such as USP, BP, JP, etc. ; - An effective tool for discovering new with old drugs and new drug target identification; - Covers various research areas, such as Cancer, Cardiovascular disease, Neuroscience, Immunology/Inflammation, respiratory system disease, etc. - More detailed compound information with structure, target, activity, IC50 value, and brief introduction; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1010. Categories: FDA-Approved & Pharmacopeia Drug Libraries.
A unique collection of 246 fragment-like small molecules for FBDD; - NMR and HPLC/LCMS validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5700. Categories: Featured Fragment Libraries.
Featured Novel Bioactive Compound Library
Well-chosen quantity: only contains 990 bioactive compounds after careful selection; - Cover diversified species: virus, bacterial, parasite, etc. ; - Uniqueness in structure: less studied with greater research space and values than classic bioactive compound structures; - Diversified targets: covering 235 targets, including different levels of targets, such as single protein, cell, tissue, etc. ; - Detailed compound information about activity testing method; - Powerful tool for drug discovery and target identification. Uses: Scientific use. Product Category: L4150. Categories: Featured Novel Bioactive Compounds Libraries.
A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study?- Covers various targets such as GPX4, ROS, p53, Nrf2, etc. ?- Some compounds are FDA approved; - Detailed compound information with structure, target, and biological activity description?- NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L8700. Categories: Ferroptosis Compounds Libraries.
A unique collection of 252 flavonoids can be used for high throughput and high content screening?- Most compounds have confirmed bioactivity with anticancer, anti-inflammatory, anti-oxidative, and neuroprotective effects?- Detailed compound information with structure, target, and biological activity description?- NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L6120. Categories: Flavonoid Natural Product Libraries.
Fluorochemical Library
A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS); - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - NMR and HPLC validated to ensure high purity and quality; - All compounds are in stock. Uses: Scientific use. Product Category: L5100. Categories: Fluorochemical Libraries.
Food as Medicine Compound Library
A unique collection of 960 compounds from food as medicine for high throughput and high content screening; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L6300. Categories: Food as Medicine Compounds Libraries.
A unique collection of 455 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and cancer; - Targets include glutaminase?GLS??ASCT2?glutamate dehydrogenase?c-Myc, etc. - Some compounds have been approved by the FDA; - Structurally diverse, medicinally active, and cell permeable; - Detailed compound information with structure, target, IC50 value, and bioactivity information; - NMR and HPLC/LCMS validated to ensure high purity. Uses: Scientific use. Product Category: L2550. Categories: Glutamine Metabolism Compounds Libraries.
Glycometabolism Compound Library
708 glycometabolism-related comounds, can be used for HTS and HCT; - Targets contain GLUTs?Hexokinase?HK??Pyruvate Kinase?PK??phosphofructokinase?PFK??IDH1/2?LDH?AMPK, etc. ; - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. - All compounds are in stock. Uses: Scientific use. Product Category: L2520. Categories: Glycometabolism Compounds Libraries.