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Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway. Group: Inhibitors. Alternative Names: 8-Methoxy-6-aminophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid 5,6-lactam. CAS No. 13395-02-3. Molecular formula: C17H11NO4. Mole weight: 293.27. Appearance: Powder. Purity: 0.98. IUPACName: 14-Methoxy-3, 5-dioxa-10-azapentacyclo[9.7.1.02, 6.08, 19.013, 18]nonadeca-1(18), 2(6), 7, 11(19), 12, 14, 16-heptaen-9-one. Canonical SMILES: COC1=CC=CC2=C3C4=C (C=C21)NC (=O)C4=CC5=C3OCO5. Density: 1.49 g/ml. Catalog: ACM13395023.
Arnica Extract
Also called Mountain Tabacco. Arnica Extract is made from the flower part & is primarily used in skin & hair care (external use). Contains 20% extract dissolved in water and glycerin. Uses: Face toners, cleansers, masks, skin lotions, creams. Group: Humectants. CAS No. 56-81-5 / 7732-18-5 / 68990-11-4 / 122-99-6. Appearance: Light to medium amber liquid. Catalog: CI-SC-0021.
Heterocyclic Organic Compound. CAS No. 11096-82-5. Molecular formula: PCB C12H5CI5 AND C12H4CI6 AND C12H2CI8. Mole weight: 60. Catalog: ACM11096825.
Arsthinol
Arsthinol is an antiprotozoal agent which may have anti-cancer activity. It was found that arsthinol, a trivalent organoarsenic compound (dithiarsolane), has been active in vitro on leukemia cell lines and offers a better therapeutic index than arsenic trioxide, as estimated by the ratio LD50/IC50. Arsthinol induced growth inhibition of NB4 cells at lower concentration (IC50 (concentration inhibiting growth by 50%) = 0.78 +/- 0.08 micromol/l after 24 h) than As(2)O(3) (IC50 = 1.60 +/- 0.23 micromol/l after 24 h) or melarsoprol (IC50 = 1.44 +/- 0.08 micromol/l after 24 h). Arsthinol-cyclodextrin complex demonstrated to have was more effective than arsenic trioxide (As2O3) and melarsoprol on the U87 MG cell line. Importantly, in the in vivo study, significant antitumor activity against heterotopic xenografts was observed after i.p. administration. Group: Others. Alternative Names: Arsthinenol; Arsthinol; Balarsen; Mercaptoarsenol. CAS No. 119-96-0. Molecular formula: C11H14AsNO3S2. Mole weight: 347.28. Appearance: Solid powder. Purity: >98%. IUPACName: N-(2-hydroxy-5-(4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl)phenyl)acetamide. Canonical SMILES: OC1=CC=C([As](S2)SCC2CO)C=C1NC(C)=O. ECNumber: 204-361-7. Catalog: ACM119960.
Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B shows anti-SARS-CoV-2 potential with an EC50 of 10.28 μM. Group: Inhibitors. CAS No. 50906-56-4. Molecular formula: C15H20O3. Mole weight: 248.3. Appearance: Powder. Purity: 0.98. Canonical SMILES: CC1CCC2C(=C)C(=O)OC23C1CCC4(C3O4)C. Catalog: ACM50906564.
Artemether
Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.Target: AntiparasiticArtemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis. Group: Inhibitors. CAS No. 71963-77-4. Molecular formula: C16H26O5. Mole weight: 298.37. Appearance: Solid. Purity: 0.98. Canonical SMILES: C[C@H]1[C@@H] (OC)O[C@@]2 ([H])[C@]34[C@@] ([C@H] (C)CC[C@]41[H]) ([H])CC[C@@] (O2) (C)OO3. Catalog: ACM71963774.
Artemisinin
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects. Group: Inhibitors. Alternative Names: Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one. CAS No. 63968-64-9. Molecular formula: C15H22O5. Mole weight: 282.33. Appearance: White powder. Purity: 0.98. IUPACName: (1R, 4S, 5R, 8S, 9R, 12S, 13R)-1, 5, 9-trimethyl-11, 14, 15, 16-tetraoxatetracyclo[10.3.1.04, 13.08, 13]hexadecan-10-one. Canonical SMILES: C[C@@H]1CC[C@H]2[C@H] (C (=O)O[C@H]3[C@@]24[C@H]1CC[C@] (O3) (OO4)C)C. Density: 1.098 g/ml. Catalog: ACM63968649.
Artemisitene
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability. Group: Inhibitors. CAS No. 101020-89-7. Molecular formula: C15H20O5. Mole weight: 280.32. Appearance: Solid. Purity: 0.9874. Canonical SMILES: C=C1[C@@] (CC[C@H]2C) ([H])[C@@] ([C@@]2 ([H])CC3) (OO4)[C@@] (OC1=O) ([H])O[C@@]34C. Catalog: ACM101020897.
Artesunate
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Group: Inhibitors. Alternative Names: 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid. CAS No. 88495-63-0. Molecular formula: C19H28O8. Mole weight: 384.42. Appearance: White powder. Purity: 0.98. IUPACName: 4-Oxo-4-[[(1R, 4S, 5R, 8S, 9R, 10S, 12R, 13R)-1, 5, 9-trimethyl-11, 14, 15, 16-tetraoxatetracyclo[10.3.1.04, 13.08, 13]hexadecan-10-yl]oxy]butanoic acid. Canonical SMILES: C[C@@H]1CC[C@H]2[C@H] ([C@@H] (O[C@H]3[C@@]24[C@H]1CC[C@] (O3) (OO4)C)OC (=O)CCC (=O)O)C. Density: 1.21 g/ml. Catalog: ACM88495630.
Ascorbyl glucoside is a form of vitamin C that is used in skincare and cosmetic products. It is a water-soluble derivative of vitamin C that is more stable and less irritating than pure vitamin C. It is a potent antioxidant that protects the skin from damaging free radicals and helps to brighten the complexion by inhibiting melanin production. Ascorbyl glucoside also promotes collagen synthesis, which can help to improve the texture and elasticity of the skin, and has anti-inflammatory properties that can help to soothe and calm irritated skin. Overall, ascorbyl glucoside is a popular ingredient in anti-aging, brightening, and protective skincare products. Uses: 1. ascorbyl glucoside is a stable form of vitamin c that is used in skincare products. 2. it helps in brightening the skin and reducing dark spots and hyperpigmentation. 3. it is known for its antioxidant properties that protect the skin from harmful free radicals. 4. ascorbyl glucoside also helps in collagen synthesis, which improves skin elasticity and reduces fine lines and wrinkles. 5. it is s. Group: Material of cosmetics. Alternative Names: Ascorbic acid 2-O-glucoside;2-O-alpha-D-Glucopyranosyl-L-ascorbic acid;L-Ascorbic acid 2-O-alpha-glucoside. CAS No. 129499-78-1. Molecular formula: C12H18O11. Mole weight: 338.26. Appearance: white to off-white powder or crystalline powder. Density: 1.83 g/cm³. Catalog: ACM129499781.
Ascr#18
Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections. Group: Inhibitors. CAS No. 1355681-10-5. Molecular formula: C17H32O6. Mole weight: 332.43. Appearance: Solid. Purity: 0.98. Canonical SMILES: C[C@@H] (O[C@H] (O[C@@H] (C)[C@@H] (C1)O)[C@@H]1O)CCCCCCCCC (O)=O. Catalog: ACM1355681105.
Natural extract obtained from the roots of the Ashwagandha plant dissolved in a base of glycerin and water. Other common names are: Indian Ginseng or Winter Cherry. Uses: Serums, creams & lotions, anti-aging products, sun- and after-sun care, hair care products. Group: Humectants. CAS No. 56-81-5 / 7732-18-5 / 90147-43-6 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0026.
Asiatic Acid
Asiatic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Asiatic Acid is a neuroprotectant and induces of apoptosis in HepG2 human hepatoma cells. Group: Inhibitors. Alternative Names: 2α,3β,23-Trihydroxyurs-12-en-28-oicacid. CAS No. 464-92-6. Molecular formula: C30H48O5. Mole weight: 488.7. Appearance: White powder. Purity: 0.98. IUPACName: (1S, 2R, 4aS, 6aR, 6aS, 6bR, 8aR, 9R, 10R, 11R, 12aR, 14bS)-10, 11-dihydroxy-9-(hydroxymethyl)-1, 2, 6a, 6b, 9, 12a-hexamethyl-2, 3, 4, 5, 6, 6a, 7, 8, 8a, 10, 11, 12, 13, 14b-tetradecahydro-1H-picene-4a-carboxylic acid. Canonical SMILES: C[C@@H]1CC[C@@]2 (CC[C@@]3 (C (=CC[C@H]4[C@]3 (CC[C@@H]5[C@@]4 (C[C@H] ([C@@H] ([C@@]5 (C)CO)O)O)C)C)[C@@H]2[C@H]1C)C)C (=O)O. Density: 1.18±0.1 g/ml. Catalog: ACM464926.
This compound is a cytotoxic glycoalkaloid and a commonly found secondary metabolite in the plants of the genus Solanum. Solamargine penetrates cell membrane, inhibits growth of tumoral cell lines and induces apoptosis at low micromolar concentrations. It also sensitises cancer cell lines to the treatment with chemotherapeutic agents, such as cisplatin, epirubicin and trastuzumab. The compound was seen to inhibit P-glycoprotein in neuroblastoma cell line. Group: Other alkaloids. Alternative Names: Solasodine-L-rhamnosido-D-glucoside(3b,22a,25R)-Spirosol-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1?2)-O-[6-deoxy-a-L-mannopyranosyl -(1?4)]-b-D-glucopyranoside. CAS No. 20311-51-7. Molecular formula: C45H73NO15. Mole weight: 868.06 g/mol. Canonical SMILES: C[C@@H]1CC[C@@]2 ([C@H] ([C@H]3[C@@H] (O2)C[C@@H]4[C@@]3 (CC[C@H]5[C@H]4CC=C6[C@@]5 (CC[C@@H] (C6)O[C@H]7[C@@H] ([C@H] ([C@@H] ([C@H] (O7)CO)O[C@H]8[C@@H] ([C@@H] ([C@H] ([C@@H] (O8)C)O)O)O)O)O[C@H]9[C@@H] ([C@@H] ([C@H] ([C@@H] (O9)C)O)O)O)C)C)C)NC1. Catalog: ACM20311517-1.
Aspartame-d3 is the deuterium labeled Aspartame. Aspartame is an important sweetener that is widely used in pharmaceutical processing and food processing. Group: Isotope-labeled environmental contaminants. Alternative Names: SC-18862-d3. CAS No. 1356841-28-5. Molecular formula: C14H15D3N2O5. Mole weight: 297.32. Canonical SMILES: OC (C[C@H] (N)C (N[C@H] (C (OC ([2H]) ([2H])[2H])=O)CC1=CC=CC=C1)=O)=O. Catalog: ACM1356841285.
Aspartame-d5
Aspartame-d5 is the deuterium labeled Aspartame. Aspartame is an important sweetener that is widely used in pharmaceutical processing and food processing. Group: Isotope-labeled environmental contaminants. Alternative Names: L-α-Aspartyl-L-phenylalanine 2-(methyl-d5) ester. CAS No. 1356849-17-6. Molecular formula: C14H13D5N2O5. Mole weight: 299.33. Appearance: White solid. IUPACName: (3S)-3-amino-4-[[(2S)-1-methoxy-1-oxo-3-(2,3,4,5,6-pentadeuteriophenyl)propan-2-yl]amino]-4-oxobutanoic acid. Canonical SMILES: [2H]C1=C ([2H])C ([2H])=C ([2H])C ([2H])=C1C[C@@H] (C (OC)=O)NC ([C@@H] (N)CC (O)=O)=O. Catalog: ACM1356849176.
Aspericin C
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Group: Marine natural products. CAS No. 1216840-17-3. Mole weight: 298.42. Purity: 95%+. Catalog: ACM1216840173.
Asperosaponin Vi
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP-2/p38 and ERK1/2 pathway. Asperosaponin ? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. Group: Inhibitors. CAS No. 39524-08-8. Molecular formula: C47H76O18. Mole weight: 929.1. Appearance: White powder. Purity: 0.98. IUPACName: [(3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (6aS,9R)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate. Canonical SMILES: CC1 (CCC2 (CCC3 (C (=CCC4C3 (CCC5C4 (CCC (C5 (C)CO)OC6C (C (C (CO6)O)O)O)C)C)C2C1)C)C (=O)OC7C (C (C (C (O7)COC8C (C (C (C (O8)CO)O)O)O)O)O)O)C. Catalog: ACM39524088.
Aspoxicillin
Aspoxicillin is classified under the β-lactam family of antibiotics. Group: Others. Alternative Names: Aspoxicillin; TA 058; TA058; TA-058. CAS No. 63358-49-6. Molecular formula: C21H27N5O7S. Mole weight: 493.54. Appearance: Solid powder. Purity: >98%. IUPACName: Glycinamide, N-methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-D-2-(4-hydroxyphenyl)-, (2S-(2-alpha,5-alpha,6-beta))-. Canonical SMILES: O=C (N)[C@@H] (C1=CC=C (O)C=C1)N (C ([C@@H] (CC (N)=O)NC)=O)[C@H]2[C@@]3 ([H])SC (C) (C)C (C (O)=O)N3C2=O. Catalog: ACM63358496.
Astec Cyclobond I-AC
Heterocyclic Organic Compound. Alternative Names: MONOACETYL-BETA-CYCLODEXTRIN. CAS No. 113573-77-6. Catalog: ACM113573776.
Astilbin
Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation. Group: Inhibitors. CAS No. 29838-67-3. Molecular formula: C21H22O11. Mole weight: 450.39. Purity: 0.98. Catalog: ACM29838673.
ASTX-029
ASTX029 is a highly potent and selective dual-mechanism ERK inhibitor. ASTX029 inhibits both ERK catalytic activity and the phosphorylation of ERK itself by MEK, despite not directly inhibiting MEK activity. ASTX029 preferentially inhibited the proliferation of MAPK-activated cell lines, including those with BRAF or RAS mutations. ASTX029 also demonstrated activity in both in vitro and in vivo models of acquired resistance to MAPK pathway inhibitors. Group: Inhibitors. Alternative Names: ASTX-029; ASTX029; ASTX 029. CAS No. 2095719-92-7. Molecular formula: C29H31ClFN5O5. Mole weight: 584.05. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. Canonical SMILES: ClC (C (C1=CC=C2C (C (N ([C@H] (C) C (N[C@H] (CO) C3=CC (OC) =CC (F) =C3) =O) C2) =O) =C1) =N4) =CN=C4NC5CCOCC5. Catalog: ACM2095719927.
At9283
AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo. Group: Inhibitors. Alternative Names: 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaAT9283;AT9283, >=98%;N-cyclopropyl-N-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.438. Purity: 0.997. Density: 1.45. Catalog: ACM896466049.
Atovaquone-d5 is the deuterium labeled Atovaquone. Group: Isotope-labeled environmental contaminants. Alternative Names: Atavaquone-d5. CAS No. 1329792-63-3. Molecular formula: C22H14D5ClO3. Mole weight: 371.87. Canonical SMILES: O=C1C ([C@@]2 ([2H])C ([2H]) ([2H])C[C@H] (C3=CC=C (C=C3)Cl)CC2 ([2H])[2H])=C (C (C4=CC=CC=C41)=O)O. Catalog: ACM1329792633.
Atropine sulfate anhydrous
Atropine sulfate anhydrous is a bioactive substance that is present in many plants, especially the Atropa belladonna plant. It can be used as a pharmaceutical drug for activating or blocking the action of other drugs in the body. Atropine sulfate anhydrous is used in vivo to treat various conditions, such as bradycardia, hypotension, and Parkinson's disease. It has been shown to be effective in vitro against adriamycin-induced cytotoxicity and activation of mammalian cells. This drug also has predictable effects on human cell lines and animal models of carcinogenesis. Group: Other alkaloids. CAS No. 55-48-1. Molecular formula: C34H48N2O10S. Mole weight: 676.80 g/mol. Canonical SMILES: CN1C2CCC1CC (OC (C (C3=CC=CC=C3)CO)=O)C2. Catalog: ACM55481-1.
Atropine sulfate monohydrate
Atropine sulfate is a cholinergic drug that inhibits the enzyme acetylcholinesterase. It is used to treat bradycardia and to reduce the spasms of smooth muscle, including those of the bronchi, gastrointestinal tract, uterus, bladder and urinary passages. Atropine sulfate also has been used as an antidote for poisoning by organophosphates and other cholinesterase inhibitors. The drug is readily absorbed from the gastrointestinal tract, with peak plasma concentrations occurring about one hour after ingestion. The half-life is about three hours. The major route of elimination is via renal excretion of unchanged drug in urine. Group: Other alkaloids. Alternative Names: a-(Hydroxymethyl)benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate hydrateAtropine sulfate hydrateAtr opisol. CAS No. 5908-99-6. Molecular formula: C34H50N2O11S. Mole weight: 694.83 g/mol. Canonical SMILES: CN1[C@@H]2CC[C@H]1CC (C2)OC (=O)C (CO)C3=CC=CC=C3. CN1[C@@H]2CC[C@H]1CC (C2)OC (=O)C (CO)C3=CC=CC=C3. O. OS (=O) (=O)O. Catalog: ACM5908996-2.
Aumitin
Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Group: Inhibitors. CAS No. 946293-78-3. Molecular formula: C24H20ClN5O. Mole weight: 429.91. Appearance: Solid powder. Purity: >98%. IUPACName: 2-Chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide. Canonical SMILES: O=C (NC1=CC=C (NC2=NC (NC3=CC=CC=C3)=CC (C)=N2)C=C1)C4=CC=CC=C4Cl. Catalog: ACM946293783.
Auranofin
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2?μM for monkey kidney Vero E6 cells. Group: Inhibitors. CAS No. 34031-32-8. Molecular formula: C20H34AuO9PS. Mole weight: 678.48. Appearance: Solid. Purity: >98%. Canonical SMILES: CC (O[C@@H]1[C@@H] (OC (C)=O)[C@H] ([SH-][Au+]P (CC) (CC)CC)O[C@H] (COC (C)=O)[C@H]1OC (C)=O)=O. Catalog: ACM34031328.
Aurintricarboxylic Acid
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM. Group: Inhibitors. Alternative Names: Ata. CAS No. 4431-00-9. Molecular formula: C22H14O9. Mole weight: 422.34. Appearance: Powder. Purity: 0.85. Canonical SMILES: C1=CC (=C (C=C1C (=C2C=CC (=O)C (=C2)C (=O)O)C3=CC (=C (C=C3)O)C (=O)O)C (=O)O)O. Catalog: ACM4431009.
Avicularin
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Group: Inhibitors. CAS No. 572-30-5. Molecular formula: C20H18O11. Mole weight: 434.4. Appearance: Yellow powder. Purity: 0.98. IUPACName: 3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one. Canonical SMILES: C1=CC (=C (C=C1C2=C (C (=O)C3=C (C=C (C=C3O2)O)O)OC4C (C (C (O4)CO)O)O)O)O. Catalog: ACM572305.
Avobenzone
Oil-soluble UVA filter. Ability to absorb ultraviolet light over a wider range of wavelengths than many other sunscreen agents. Absorption maximum of 357 nm. Uses: Sun care products, baby sun care products, daily sun protection, decorative cosmetics. Group: Heterocyclic organic compound. Alternative Names: Butyl methoxydibenzoylmethane. CAS No. 70356-09-1. Molecular formula: C20H22O3. Mole weight: 310.4. Appearance: Off-white to yellowish, crystalline powder, weak odor. Purity: 97-104%. Density: 1.079. Catalog: ACM70356091.
Avocado Butter
Natural avocado seed oil extracted from the flesh of the avocado fruit, combined with soybean lipids and beeswax to a creamy texture. Uses: Creams, lotions, pomades, lip balms, lipsticks, hair pomades, makeup products, conditioners. Group: Skin actives. CAS No. 8024-32-6/8012-89-3. Appearance: Soft, creamy butter, no odor. Catalog: CI-SC-0988.
Avocado Extract
Extract obtained from Persea Gratissima (Avocado) fruits. Contains 20% extract dissolved in water and glycerin. Contains high amounts of vitamin B2, D, A, E and K and potassium. Has anti-irritating and soothing properties and is often used as skin-nutrient. Uses: Creams, lotions, masks and hair care products. Group: Skin actives. CAS No. 7732-18-5/56-81-5/8024-32-6/122-99-6. Appearance: Pale to medium yellow liquid, characteristic odor. Catalog: CI-SC-0795.
AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. Group: Inhibitors. Alternative Names: AZ32; AZ-32; AZ 32. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.38. Appearance: Solid powder. Purity: >98%. IUPACName: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Canonical SMILES: O=C (NC)C (C=C1)=CC=C1C2=CN=C3C=NC (C4=CC=CC=C4)=CN32. Catalog: ACM2288709964.
Azadirachtin a
Heterocyclic Organic Compound. Alternative Names: NEEMOLIN; NEEMAZAD; NEEMAZAL; NEEMIX; AZAD; AZADIRACCHTIN A;AZADIRACHTIN;AZADIRACHTIN A. CAS No. 11141-17-6. Molecular formula: C35H44O16. Mole weight: 720.71. Density: 1.51. Catalog: ACM11141176.
AZADIRACHTIN B
Azardirachtin B is a feeding and growth disruptor found effective for a wide range of insects and has shown little toxicity in humans. Group: Coumarins. CAS No. 106500-25-8. Mole weight: 662.68. Appearance: White powder. Catalog: ACM106500258.
AZD4017 is a potent, selective, and orally bioavailable11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. AZD4017 is a nicotinic amide derived carboxylic acid class of inhibitors that has good potency, selectivity, and pharmacokinetic characteristics. AZD4017) is an effective inhibitor of 11β-HSD1 in human adipocytes and exhibits good druglike properties and as a consequence was selected for clinical development. Group: Inhibitors. Alternative Names: AZD4017; AZD-4017; AZD 4017. CAS No. 1024033-43-9. Molecular formula: C22H33N3O3S. Mole weight: 419.58. Appearance: Solid powder. Purity: >98%. IUPACName: 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid. Canonical SMILES: O=C (O)C[C@H]1CN (C2=NC (SCCC)=C (C (NC3CCCCC3)=O)C=C2)CCC1. Catalog: ACM1024033439.
AZD-4818
AZD-4818 is a chemokine CCR1 antagonist that is used for the treatment of chronic obstructive pulmonary disease. Group: Antagonists. Alternative Names: AZD-4818; AZD 4818; AZD4818. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-. Canonical SMILES: CC (C) (OC1=CC (OC[C@@H] (O)CN2CCC3 (CC2)OC4=CC=C (Cl)C=C4C3)=C (C (NC)=O)C=C1Cl)C (O)=O. Catalog: ACM1003566935.
AZD-5099
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection. Group: Others. Alternative Names: AZD-5099; AZD 5099; AZD5099. CAS No. 907543-25-3. Molecular formula: C21H27Cl2N5O6S. Mole weight: 548.44. Appearance: Solid powder. Purity: >98%. IUPACName: 2-((3S,4R)-4-(3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamido)-3-methoxypiperidin-1-yl)-4-(((S)-1-methoxypropan-2-yl)carbamoyl)thiazole-5-carboxylic acid. Canonical SMILES: O=C (C1=C (C (N[C@@H] (C)COC)=O)N=C (N2C[C@H] (OC)[C@H] (NC (C3=C (Cl)C (Cl)=C (C)N3)=O)CC2)S1)O. Catalog: ACM907543253.
AZD5305
AZD5305 is a potent, selective and oral active PARP inhibitor. AZD5305 is a highly potent inhibitor of PARP1, with significant PARP1-DNA trapping activity, no PARP2-activity, nor binding activity to any other members of the PARP family. AZD5305 has excellent secondary pharmacology and physicochemical properties as well as high oral bioavailability in preclinical species. Group: Inhibitors. Alternative Names: AZD5305; AZD-5305; AZD 5305. CAS No. 2589531-76-8. Molecular formula: C22H26N6O2. Mole weight: 406.49. Appearance: Solid powder. Purity: >98%. IUPACName: 5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)-N-methylpicolinamide. Canonical SMILES: O=C (C1=NC=C (N2CCN (CC3=CC (N4)=C (N=C3)C=C (CC)C4=O)CC2)C=C1)NC. Catalog: ACM2589531768.
AZD8186
AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials. Group: Inhibitors. Alternative Names: AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide. Canonical SMILES: O=C (N (C)C)C1=CC ([C@@H] (C)NC2=CC (F)=CC (F)=C2)=C3C (C (C=C (O3)N4CCOCC4)=O)=C1. Catalog: ACM1627494136.
Azelastine hydrochloride
Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2. Group: Inhibitors. Alternative Names: a5610;azeptin;e-0659;w-2979m;AZELASTINE HCL;AZELASTINE HYDROCHLORIDE;4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride;4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride. CAS No. 79307-93-0. Molecular formula: C22H25Cl2N3O. Mole weight: 418.36. Purity: 0.9993. Catalog: ACM79307930.
Azido-PEG3-alcohol
Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Group: Azido peg linkers. Alternative Names: 1-Azido-8-hydroxy-3,6-dioxaoctane. CAS No. 86520-52-7. Molecular formula: C6H13N3O3. Mole weight: 175.19. Appearance: Oil. Purity: >90%. IUPACName: 2-[2-(2-Azidoethoxy)ethoxy]ethanol. Canonical SMILES: C(COCCOCCO)N=[N+]=[N-]. Catalog: ACM86520527.
Azido-PEG3-aldehyde
Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Group: Other peg linkers. Alternative Names: N3-PEG3-CHO. CAS No. 1807530-10-4. Molecular formula: C9H17N3O4. Mole weight: 231.25. Appearance: Liquid. Purity: >90%. IUPACName: 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanal. Canonical SMILES: C(COCCOCCOCCN=[N+]=[N-])C=O. Catalog: ACM1807530104.
Azido-PEG3-NHS ester
N3-PEG3-C2-NHS ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). Group: Azido peg linkers. Alternative Names: N3-PEG3-C2-NHS ester. CAS No. 1245718-89-1. Molecular formula: C13H20N4O7. Mole weight: 344.32. Appearance: Solid or viscous liquid. Purity: >90%. IUPACName: (2,5-Dioxopyrrolidin-1-yl) 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate. Canonical SMILES: C1CC (=O)N (C1=O)OC (=O)CCOCCOCCOCCN=[N+]=[N-]. Catalog: ACM1245718891.
Azido-PEG4-alcohol
Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Group: Azido peg linkers. Alternative Names: 11-Azido-3,6,9-trioxaundecanol. CAS No. 86770-67-4. Molecular formula: C8H17N3O4. Mole weight: 219.24. Appearance: Oil. Purity: >90%. IUPACName: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethanol. Canonical SMILES: C(COCCOCCOCCO)N=[N+]=[N-]. Catalog: ACM86770674.
Azido-PEG4-NHS ester
N3-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). Group: Azido peg linkers. Alternative Names: N3-PEG4-C2-NHS ester. CAS No. 944251-24-5. Molecular formula: C15H24N4O8. Mole weight: 388.37. Appearance: Solid or viscous liquid. Purity: >90%. IUPACName: (2,5-Dioxopyrrolidin-1-yl) 3-[2-[2-[2- (2-azidoethoxy) ethoxy]ethoxy]ethoxy]propanoate. Canonical SMILES: C1CC (=O)N (C1=O)OC (=O)CCOCCOCCOCCOCCN=[N+]=[N-]. Catalog: ACM944251245.
Azido-PEG5-alcohol
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Group: Azido peg linkers. Alternative Names: 1-Azidohexaethylene glycol. CAS No. 86770-68-5. Molecular formula: C10H21N3O5. Mole weight: 263.29. Appearance: Oil. Purity: >90%. IUPACName: 2-[2-[2-[2- (2-Azidoethoxy) ethoxy]ethoxy]ethoxy]ethanol. Canonical SMILES: C(COCCOCCOCCOCCO)N=[N+]=[N-]. Catalog: ACM86770685.
Azido-PEG5-NHS ester
Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Group: Azido peg linkers. Alternative Names: N3-PEG5-SPA. CAS No. 1433996-86-1. Molecular formula: C17H28N4O9. Mole weight: 432.4. Appearance: Liquid. Purity: >90%. IUPACName: (2,5-Dioxopyrrolidin-1-yl) 3- [2- [2- [2- [2- (2-azidoethoxy) ethoxy] ethoxy] ethoxy] ethoxy] propanoate. Canonical SMILES: C1CC (=O)N (C1=O)OC (=O)CCOCCOCCOCCOCCOCCN=[N+]=[N-]. Catalog: ACM1433996861.
Azido-PEG6-alcohol
Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Group: Azido peg linkers. Alternative Names: N3-PEG6-OH. CAS No. 86770-69-6. Molecular formula: C12H25N3O6. Mole weight: 307.34. Appearance: Liquid. Purity: >90%. IUPACName: 2-[2-[2-[2-[2- (2-Azidoethoxy) ethoxy]ethoxy]ethoxy]ethoxy]ethanol. Canonical SMILES: C(COCCOCCOCCOCCOCCO)N=[N+]=[N-]. Catalog: ACM86770696.
Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a methoxyacrylate fungicidal pesticide with high efficiency and broad spectrum. It is effective against almost all fungal kingdom (Ascomycotina, Basidiomycotina, Flagellate and Deuteromycotina) diseases such as powdery mildew and rust, green leaf spot, net spot, downy mildew, rice blast, etc. all have good activity. Group: Isotope-labeled environmental contaminants. CAS No. 1346606-39-0. Molecular formula: C22H13D4N3O5. Mole weight: 407.41. Canonical SMILES: [2H]C1=C ([2H])C ([2H])=C ([2H])C (C#N)=C1OC2=NC=NC (OC3=CC=CC=C3/C (C (OC)=O)=C\OC)=C2. Catalog: ACM1346606390.