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Cannibis Sativia Flower/Leaf/Stem Extract
Cannabis Sativa Flower/Leaf/Stem Extract is a natural extract obtained from the flowers, leaves, and stems of the Cannabis Sativa plant. It contains various compounds like cannabinoids, terpenes, and flavonoids, which are known for their medicinal and therapeutic properties. Cannabinoids, such as CBD (cannabidiol) and THC (tetrahydrocannabinol), have been researched for their potential in pain relief, reducing anxiety and depression symptoms, and treating certain neurological disorders. Terpenes are responsible for the fragrances and scents of the plant, and may also have health benefits. Flavonoids are known for their antioxidant properties and may contribute to the overall health benefits of the extract. The use of Cannabis Sativa Flower/Leaf/Stem Extract is regulated by law and can vary depending on the jurisdiction. Uses: 1. pain relief: cannabis sativa flower/leaf/stem extract is used as a natural pain reliever due to its analgesic properties. 2. anxiety and stress reduction: the extract has anxiolytic properties and can help reduce symptoms of anxiety and stress. 3. inflammation reduction: cannabis sativa extract can help reduce inflammation due to its anti-inflammatory effects. 4. neurological conditions managem. Group: Emollients/oils/wax. CAS No. 89958-21-4. Appearance: greenish-brown color and a sticky texture. Catalog: CI-SC-0494.
cantuzumab mertansine
Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts. Group: Inhibitors. Alternative Names: cantuzumab mertansine. CAS No. 400010-39-1. Canonical SMILES: [Cantuzumab mertansine]. Catalog: ACM400010391.
Capecitabine
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Group: Inhibitors. Alternative Names: 5-DEOXY-5-FLUOROCYTISINE; 5-DEOXY-5-FLUORO-N-[(PENTYLOXY)CARBONYL]CYTIDINE; CAPECITABINE; RO-9-1978; pentyl [1-(3, 4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate; XELODA; Cpecitabine; 5Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine, Ro-9-1978, Xeloda. CAS No. 154361-50-9. Molecular formula: C15H22FN3O6. Mole weight: 359.35. Appearance: Solid. Purity: 0.9987. Canonical SMILES: O[C@H]1[C@@H] (O)[C@H] (N2C=C (C (NC (OCCCCC)=O)=NC2=O)F)O[C@@H]1C. Catalog: ACM154361509.
Capecitabine-d11
Capecitabine-d11 is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Group: Inhibitors. Alternative Names: 5'-DEOXY-5-FLUORO-N-[(PENTYLOXY)CARBONYL]CYTIDINE-D11;CAPECITABINE-D11. CAS No. 1132662-08-8. Molecular formula: C15H11D11FN3O6. Mole weight: 372.43. Appearance: Off-White Solid. Canonical SMILES: C[C@@H]1[C@H] ([C@H] ([C@H] (N2C (N=C (C (F)=C2)NC (OC ([2H]) ([2H])C ([2H]) ([2H])C ([2H]) ([2H])C ([2H]) ([2H])C ([2H]) ([2H])[2H])=O)=O)O1)O)O. Catalog: ACM1132662088.
Capric triglyceride is a natural compound derived from coconuts that is used in many personal care and cosmetic products. It is a type of medium-chain triglyceride (MCT) that is made up of three capric acid molecules. Capric triglyceride is a lightweight, non-greasy oil that is easily absorbed by the skin, making it ideal for use in lotions, creams, and other skincare products. It is also a popular ingredient in hair care products and makeup, where it can help to moisturize and protect the hair and skin from damage. Capric triglyceride is known for its ability to provide long-lasting hydration without clogging pores, making it a popular choice for people with oily or acne-prone skin. It also has antimicrobial properties that can help to prevent infections and breakouts. Uses: 1. cosmetics and personal care products: capric triglyceride is used as an emollient, texture enhancer, and solvent in various skincare and personal care products, including lotions, creams, sunscreens, and hair conditioners. 2. food industry: capric triglyceride is used as a food additive to enhance the taste and texture of processed foods, including snacks, baked goods, and beverages. 3. pharmac. Group: Emollients/oils/wax. CAS No. 73398-61-5. Appearance: clear, colorless to pale yellow liquid with a neutral odor. Catalog: CI-SC-0454.
Capromorelin tartrate
Capromorelin, also known as CP-424,391, is a growth hormone secretagogue and ghrelin mimetic ( hGHS-R1a K(I)=7 nM, rat pituicyte EC(50)=3 nM). Initial studies have shown the drug to directly raise insulin growth factor 1 (IGF-1) and growth hormone levels. Capromorelin showed enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. This short-duration GHS was orally active in canine models and was selected as a development candidate for the treatment of musculoskeletal frailty in elderly adults. Group: Others. Alternative Names: CP-424,391; CP 424,391; CP424,391; CP-424391; CP 424391; CP424391; CP-424,391-18; Capromorelin tartrate. CAS No. 193273-69-7. Molecular formula: C32H41N5O10. Mole weight: 655.71. Appearance: Solid powder. Purity: >98%. IUPACName: 2-amino-N-((R)-1-((R)-3a-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide (2R,3R)-2,3-dihydroxysuccinate. Canonical SMILES: CC (C) (N)C (N[C@@H] (C (N (C[C@]12CC3=CC=CC=C3)CCC1=NN (C)C2=O)=O)COCC4=CC=CC=C4)=O. O[C@H] ([C@H] (C (O)=O)O)C (O)=O. Catalog: ACM193273697.
Caprylic Acid Combo
Blend of naturally derived ingredients for keeping products microbial-free and stable while providing additional conditioning properties. Contains natural caprylic acid and lauric acid (made from vegetable-derived fatty acids), propanediol (made from corn sugar), and potassium sorbate. Uses: Shampoos, face cleansers, emulsions, conditioners. Group: Sensory modifiers. CAS No. 124-07-2/504-63-2/143-07-7/590-00-1. Appearance: Clear liquid, water white to light amber color, mild odor. Catalog: CI-SC-0108.
Caprylyl Glycol Blend
Unique multifunctional blend with emollient and conditioning properties that contribute to antimicrobial protection. Can be used alone or can be combined with other preservatives to enhance their effectiveness. Uses: All kinds of skin care and hair care products (incl. leave-on and rinse-off products), color cosmetics. Group: Sensory modifiers. CAS No. 1117-86-8 65/142-18-7 10/62285-15-8 10. Appearance: Light yellow liquid. Catalog: CI-SC-0073.
Caprylyl Glycol EHG
Blend of caprylyl glycol (67-73%) and ethylhexylglycerin (27-33%). Glycols are known to be antimicrobial and show antimicrobial efficacy against typical germs found in cosmetic formulations. Uses: All kinds of leave-on & rinse-off personal care and cosmetic products. Group: Humectants. CAS No. 1117-86-8/70445-33-9. Appearance: Clear colorless liquid, mild odor. Catalog: CI-SC-0007.
Caprylyl Glycol, Phenoxyethanol
Formaldehyde-free preservative blend for broad-spectrum protection against bacteria, mold and yeast. Content: Phenoxyethanol 53-58%, caprylyl glycol 42-47%. Uses: All kinds of skin and hair care products. Group: Actives & antimicrobials. CAS No. 1117-86-8/122-99-6. Appearance: Clear, colorless to light yellow liquid, characteristic odor. Catalog: CI-HS-0004.
Extract obtained from Capsicum Frutescens (Chili Pepper) fruits. Contains 20% extract dissolved in water and glycerin. Has stimulant and cooling properties on the skin. Uses: Creams, lotions, gels, and cleansers. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84603-55-4 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0828.
Carbadox-d3
Carbadox-d3 is the deuterium labeled Carbadox. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency. Group: Isotope-labeled environmental contaminants. CAS No. 1185240-06-5. Molecular formula: C11H7D3N4O4. Mole weight: 265.24. Canonical SMILES: [O-][N+]1=C2C=CC=CC2=[N+] ([O-])C (/C=N/NC (OC ([2H]) ([2H])[2H])=O)=C1. Catalog: ACM1185240065.
Carbamazepine-d2,15N
Carbamazepine-d2 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent. Group: 15n labeled compounds. Alternative Names: CBZ-d2; NSC 169864-d2. CAS No. 1189902-21-3. Molecular formula: C15H10D2N15NO. Mole weight: 239.27. Appearance: White solid. Canonical SMILES: NC (N1C2=CC=CC=C2C ([2H])=C ([2H])C3=CC=CC=C31)=O. Density: 1.3±0.1 g/cm3. Catalog: ACM1189902213.
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication. Group: Inhibitors. Alternative Names: Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo, disodium salt, (3beta,20beta)-. CAS No. 7421-40-1. Molecular formula: C34H48Na2O7. Mole weight: 614.72. Appearance: White Solid. Purity: >98 %. Canonical SMILES: CC (C) ([C@]1 ([H])CC[C@@] ([C@@]2 (CC[C@]3 (CC[C@] (C[C@@]3 ([H])C2=C4) (C)C (O[Na])=O)C)C)5C)[C@@H] (OC (CCC (O[Na])=O)=O)CC[C@]1 (C)[C@@]5 ([H])C4=O. Catalog: ACM7421401.
Carbomer is a term used for a group of synthetic high molecular weight polymers, such as polyacrylic acid, Cross-linked polyacrylic acid, or polymethacrylic acid. These polymers are generally used as thickening agents, emulsifiers, and stabilizers in cosmetic and personal care products. Carbomers work by absorbing and swelling in water, forming a gel-like consistency. When added to lotions, creams, gels, or other skincare products, carbomers give the product a thicker and more luxurious feel. They can also help to stabilize the formula and prevent it from separating or becoming runny. Uses: 1. carbomer is used as a thickening and suspending agent in various pharmaceuticals and personal care products like gels, creams, and lotions. 2. it helps to increase the viscosity of the product and improve its texture and stability. 3. carbomer is also used in ophthalmic solutions, nasal sprays, and oral suspensions as a suspending agent to ensure uniform drug distribution. 4. due to its excellent hydration and film-forming properties, it is utilized as a lubricant in contact lenses. 5. carbomer is widely used in the food industry as a thickener, stabilizer, and emulsifying agent. Group: Rheology modifiers. Alternative Names: Carboxypolymethylene resin;Poly(acrylic acid). CAS No. 9007-20-9. Molecular formula: C3H4O2. Appearance: white, fluffy powder. Density: 1.063 g/mL. Catalog: CI-HC-0113.
Carbomer 940
Acrylic acid is a colorless liquid with a distinctive acrid odor. Flash point 130°F. Boiling point 286°F. Freezing point 53°F. Corrosive to metals and tissue. Prolonged exposure to fire or heat can cause polymerization. If polymerization takes place in a closed container, violent rupture may occur. The inhibitor (usually hydroquinone) greatly reduces the tendency to polymerize.;Acrylic acid, [waste] appears as a colorless liquid with a distinctive acrid odor. Combustible. Flash point 130°F. Boiling point 286°F. Freezing point 121°F. Corrosive to metals and tissue. May polymerize under prolonged exposure to fire or heat. If polymerization occurs in a container violent rupture may occur. Generally shipped with an inhibitor such as hydroquinone to prevent polymerization.; Liquid; Liquid; COLOURLESS LIQUID WITH PUNGENT ODOUR.;Colorless liquid or solid (below 55°F) with a distinctive, acrid odor.;Colorless liquid or solid (below 55°F) with a distinctive, acrid odor. [Note: Shipped with an inhibitor (e.g., hydroquinone) since it readily polymerizes.]. Group: Heterocyclic organic compound. Alternative Names: Acritamer 940;Lanopol 940;Acrypol 940;Phytogel base;Carbopol 940. CAS No. 76050-42-5. Molecular formula: C3H4O2;CH2=CHCOOH;C3H4O2. Mole weight: 72.06g/mol. IUPACName: prop-2-enoic acid. Canonical SMILES: C=CC(=O)O. Density: 1.0497 at 68 °F (USCG, 1999);1.05 (NIOSH, 2016);1.0511 g/cu cm at 20 °C;1.54 g/mL at 25 °C/4 °C;Relative
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent. Uses: Data on carboplatin production have not been found. carboplatin is used in chemotherapy to treat cancer, and more particularly to treat cancer of ovary, embryonal carcinoma of the testis, microcellular carcinoma of the lung, neuroblastoma, and squamous cell carcinomas of the head and neck.carboplatin, cis-diammine (1, 1-cyclobutanedicarboxylato)platinum (II), is a second-generation platinum drug. Group: Inhibitors. Alternative Names: SR-01000076253; D01363; diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum; Carboplatin, British Pharmacopoeia (BP) Reference Standard; MFCD00070464; NSC-241240; CS-1121; NCGC00094961-02; JM-8; SPECTRUM1502106. CAS No. 41575-94-4. Molecular formula: C6H12N2O4Pt;C6H14N2O4Pt. Mole weight: 373.272g/mol. Appearance: Solid. Purity: 0.9996. IUPACName: azane;cyclobutane-1,1-dicarboxylic acid;platinum. Canonical SMILES: C1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt]. ECNumber: 255-446-0. Catalog: ACM41575944.
Carboxy Fluorescein-PEG12-NHS is a fluorescein labeled PEG linker containing a NHS group, which enables labeling for antibodies and other purified proteins at primary amines (lysine side chains). The hydrophilic PEG spacer arm increases solubility in aqueous media. Uses: For industrial and laboratory use. Group: Fluorescein-peg. CAS No. 2246595-66-2. Molecular formula: C52H68N2O22. Mole weight: 1073.1 g/mol. Purity: 0.96. Catalog: DYE-FLU-0078.
CARBOXYMETHYL CURDLAN
Heterocyclic Organic Compound. Alternative Names: CM-CURDLAN;CARBOXYMETHYL CURDLAN. CAS No. 114732-86-4. Catalog: ACM114732864.
Cardamonin
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities. Group: Inhibitors. Alternative Names: cardamonin. CAS No. 18956-16-6. Molecular formula: C16H14O4. Mole weight: 270.28. Appearance: Solid. Purity: 0.96. IUPACName: (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one. Canonical SMILES: COC1=CC (=CC (=C1C (=O)C=CC2=CC=CC=C2)O)O. Density: 1.282g/cm³. Catalog: ACM18956166.
Cardiolipin
Heterocyclic Organic Compound. CAS No. 11-24-6. Purity: 0.96. Catalog: ACM11246.
Cariprazine free base
Cariprazine, also known as RGH-188 and MP-214, is an antipsychotic drug received FDA approval on September 17, 2015. Cariprazine acts as a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. Action on the dopaminergic systems makes it also potentially useful as an add-on therapy in major depressive disorder. Cariprazine is approved for schizophrenia and bipolar disorder. It has also been investigated as a potential adjunct in treatment-resistant major depressive disorder. Group: Others. Alternative Names: Cariprazine free base; RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214. CAS No. 839712-12-8. Molecular formula: C21H32Cl2N4O. Mole weight: 427.41. Appearance: Solid powder. Purity: >98%. IUPACName: 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea. Canonical SMILES: O=C (N[C@H]1CC[C@H] (CCN2CCN (C3=CC=CC (Cl)=C3Cl)CC2)CC1)N (C)C. Catalog: ACM839712128.
Carnauba Wax
Natural vegetable wax exuded by the leaves of a palm tree (copernicia cerifera) growing in Brazil, hardest natural wax available, composed of wax esters (85%), free fatty acids, fatty alcohols & resins (15%). Type 3 grade. Melting point 80-85°C (176-185°F). Uses: Creams, salves, ointments, balms, pomades, lipsticks, mascaras, lip gloss. Group: Polymer/macromolecule. Alternative Names: WAX, CARNAUBA; carnuba; carnubawax; CARNAUBA; CARNAUBA WAX;CARNAUBA WAX, NO 1, YELLOW;CARNAUBA WAX, REFINED, NO 1, YELLOW;CARNAUBA WAX YELLOW. CAS No. 8015-86-9. Molecular formula: C16. Appearance: Yellow flakes or powder, no or faint odor. Purity: #1, yellow. Catalog: ACM8015869-1.
CAROB GALACTOMANNAN
Heterocyclic Organic Compound. CAS No. 11078-30-1. Purity: 0.96. Catalog: ACM11078301.
Carob Tree Gum
Aqueous solution of highly purified fraction of branched galactomannans obtained from the seeds of the St. John's bread tree for various cosmetic applications. Film-forming and moisturizing properties. Has also anti-aging and skin-tightening properties. Supplies additionally exceptional lubricity, luxurious slip and a remarkable end-feel to the skin. Uses: Anti-aging serums, creams, lotions, all kinds of regenerating skin care products. Group: Skin actives. CAS No. 84961-45-5 / 7732-18-5 / 9011-18-1 / 77-92-9 / 122-99-6 / 70445-33-9. Appearance: Slightly opalescent, nearly colorless, viscous, aqueous solution. Catalog: CI-SC-1000.
Carob Tree Gum & Casein
Aqueous solution of a mixture of milk-based protein hydrolysate and galactomannans obtained from seeds of locust bean gum for various cosmetic applications. Strong film-forming and skin-tightening properties. Uses: Anti-aging serums, creams, lotions, all kinds of regenerating skin care products. Group: Skin actives. CAS No. 65072-00-6 / 84961-45-5 / 7732-18-5 / 9011-18-1 / 77-92-9 / 122-99-6 / 70445-33-9. Appearance: Yellowish, viscous liquid. Catalog: CI-SC-0732.
Carob Tree Gum & Wheat Gluten
Aqueous solution of a mixture of hydrolyzed proteins isolated from wheat gluten and galactomannans obtained from seeds of locust bean gum for various cosmetic applications. Has regenerating, film-forming, anti-aging and skin-tightening properties. Forms a visco-elastic film on the skin, helping to smooth the appearance of fine wrinkles. Uses: Anti-aging serums, creams, lotions, all kinds of regenerating skin care products. Group: Skin actives. CAS No. 100684-25-1 / 84961-45-5 / 7732-18-5 / 9011-18-1 / 77-92-9 / 122-99-6 / 70445-33-9. Appearance: Yellowish, viscous liquid. Catalog: CI-SC-0581.
Carrageenan
Heterocyclic Organic Compound. Alternative Names: Gelatin, vegetable, Irish moss. CAS No. 11114-20-8. Catalog: ACM11114208.
Carrot Cells
Intact isolated cells of fresh carrot roots made from a specific enzymatic micro-dissociation process. Carrot cells are rich in hydro-soluble and lipo-soluble nutrients. They remain intact and visible even in complex. 100% natural origin formulations. Uses: Anti-aging and anti-wrinkle creams, lotions, gels, sun care & makeup. Group: Skin actives. CAS No. 284-545-1/7732-18-5. Appearance: Light-orange liquid. Catalog: CI-SC-0620.
Carrot Oil & Beta-Carotene
Blend of sunflower seed oil, carrot seed oil, and carrot extract enriched with beta-carotene and vitamin C. Beta-carotene effectively prevents and controls the production of free radicals and also reduces free radical reactions and restrict oxidative/free radicals-induced damage. Major carotenoids include beta-carotene (45-80%), alpha-carotene (15-40%) and gamma-carotene (2-10%). Carrots are also rich in carotenes, tocopherols, antioxidants, minerals and vitamin (vitamin E and K) soluble in the oleous stage. Uses: Creams and lotions, serums, face oils, hair care products. Group: Emollients/oils/wax. CAS No. 8001-21-6 / 84929-61-3 / 8015-88-1 / 7235-40-7 / 137-66-6. Appearance: Dark brown, clear oily liquid. Catalog: CI-SC-0460.
Carrot Seed Extract
Extract obtained from Daucus Carota Sativa (Carrot) seeds. Contains 20% extract dissolved in water and glycerin. Has soothing, purifying and cleansing properties. Uses: Creams, lotions, gels and especially cleansers for blemished skin. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84929-31-3 / 122-99-6. Appearance: Light to medium yellow liquid, characteristic odor. Catalog: CI-SC-0868.
Cartric
Cartric is a sample preparation reagent that can be used for the detection of infectious diseases. It has been used in analytical methods to measure redox potentials and systolic pressure. Cartric also has been shown to inhibit enzymes, such as hydroxyl group reductase, which are involved in the metabolism of drugs and other xenobiotics. This product is not cytotoxic and does not interfere with the fluorescence detector. Cartric can be used in vitro for the detection of carcinoma cell lines and p-hydroxybenzoic acid. Group: Other alkaloids. Alternative Names: RescinnamineMethyl 3,4,5-trimethoxycinnamoyl reserpatePubescine. CAS No. 24815-24-5. Molecular formula: C35H42N2O9. Mole weight: 634.72 g/mol. Canonical SMILES: CO[C@H]1[C@@H] (C[C@@H]2CN3CCC4=C ([C@H]3C[C@@H]2[C@@H]1C (=O)OC)NC5=C4C=CC (=C5)OC)OC (=O)/C=C/C6=CC (=C (C (=C6)OC)OC)OC. Catalog: ACM24815245-1.
Carvacrol
Carvonol is a kind of organic matter, chemical formula is C10H14O, it is soluble in alcohol and ether, almost insoluble in water and volatile with water vapor. It is used in spices, food additives, feed additives, Antioxidants, sanitary disinfectants, insect repellents, preservatives, deodorants, pharmaceutical intermediates. Group: Inhibitors. Alternative Names: 2-Hydroxy-4-(2-propyl)toluene. CAS No. 499-75-2. Molecular formula: C10H14O. Mole weight: 150.22. Appearance: Liquid. Purity: 0.98. IUPACName: 2-Methyl-5-propan-2-ylphenol. Canonical SMILES: CC1=C(C=C(C=C1)C(C)C)O. Density: 0.976 g/mL at 20 °C(lit.). Catalog: ACM499752.
Natural blend of castor oils and carnauba wax forming a viscous, emollient gel that can be used as base for lip care products or as alternative to petrolatum in a variety of cosmetic products. Has a high affinity with skin lipids for great emolliency and helps create an intensively moisturized feel. Melting point 62-72ºC (144-162ºF). Uses: Lipsticks, lip balms, creams, lotions, hair care products, hair styling products, creams, lotions, balms, night creams, sun care products. Group: Skin actives. CAS No. 8001-79-4/8001-78-3/8015-86-9. Appearance: Semi-transparent, yellowing gel. Catalog: CI-SC-0983.
CAY10594 is a potent phospholipase D2 inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. CAY10594 administration markedly blocked the acute liver injury in a dose-dependent manner, showing almost complete inhibition with 8 mg/kg of CAY10594. CAY10594 administration strongly blocked GSK-3β (Serine 9)/JNK phosphorylation in the APAP-induced acute liver injury model. Consistently, sustained JNK activation in the cytosol and mitochondria from hepatocytes were also decreased in CAY10594-treated mice. Group: Inhibitors. Alternative Names: CAY10594; CAY-10594; CAY 10594. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.54. Appearance: Solid powder. Purity: >98%. IUPACName: N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide. Canonical SMILES: O=C (C1=CC=C2C=CC=CC2=C1)NCCN (CC3)CCC3 (N (C4=CC=CC=C4)CN5)C5=O. Catalog: ACM1130067343.
CB-6644 is a novel allosteric selective inhibitor of the ruvbl1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. CB-6644 interacts specifically with RUVBL1/2 in cancer cells, leading to cell death. Importantly, drug-acquired-resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on-target consequence of RUVBL1/2 engagement. In xenograft models of acute myeloid leukemia and multiple myeloma, CB-6644 significantly reduced tumor growth without obvious toxicity. Group: Inhibitors. Alternative Names: CB-6644; CB 6644; CB6644. CAS No. 2316817-88-4. Molecular formula: C29H34ClFN4O5. Mole weight: 573.06. Appearance: Solid powder. Purity: >96%. IUPACName: 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide. Canonical SMILES: O=C (NCC (C) (C)CC (NC (C1=O)=C (COC)N2N1C3=CC=CC=C3CCC2)=O)C4=CC (Cl)=C (F)C=C4OCC. Catalog: ACM2316817884.
Cbz-NH-PEG2-CH2COOH
Cbz-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Group: Functional pegs. Alternative Names: 3-Oxo-1-phenyl-2,7,10-trioxa-4-azadodecan-12-oic acid. CAS No. 165454-06-8. Molecular formula: C14H19NO6. Mole weight: 297.3. Appearance: Solid or viscous liquid. Purity: >90%. IUPACName: 2-[2-[2- (Phenylmethoxycarbonylamino) ethoxy]ethoxy]acetic acid. Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCOCCOCC(=O)O. Density: 1.233±0.06 g/cm3. Catalog: ACM165454068.
Cbz-NH-PEG3-CH2COOH
Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Group: Functional pegs. Alternative Names: Z-9-Amino-4,7-dioxanonanoic acid. CAS No. 462100-05-6. Molecular formula: C16H23NO7. Mole weight: 341.36. Appearance: Liquid. Purity: >90%. IUPACName: 2-[2-[2-[2- (Phenylmethoxycarbonylamino) ethoxy]ethoxy]ethoxy]acetic acid. Canonical SMILES: C1=CC=C (C=C1)COC (=O)NCCOCCOCCOCC (=O)O. Density: 1.2±0.1 g/cm3. Catalog: ACM462100056-1.
CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway. Group: Inhibitors. Alternative Names: CC115 ; CC-115; CC 115. CAS No. 1228013-15-7. Molecular formula: C16H16N8O. Mole weight: 336.14. Appearance: Red solid powder. Purity: >98%. IUPACName: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. Canonical SMILES: O=C1CNC2=NC=C (C3=CC=C (C4=NC=NN4)N=C3C)N=C2N1CC. Catalog: ACM1228013157.
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities. Group: Inhibitors. CAS No. 469-61-4. Molecular formula: C15H24. Mole weight: 204.35. Appearance: Liquid. Purity: 0.98. Canonical SMILES: C[C@H]1[C@]2 (C[C@H]3C (C)=CC2)[C@] (CC1) ([H])C3 (C)C. Catalog: ACM469614.
Cedrol
Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, insecticidal, and anti-fungal activities. Group: Inhibitors. Alternative Names: Cypress camphor. CAS No. 77-53-2. Molecular formula: C15H26O. Mole weight: 222.37. Appearance: Pale yellow to yellow green solid. Purity: 0.99. IUPACName: (1S, 2R, 5S, 7R, 8R)-2, 6, 6, 8-Tetramethyltricyclo[5.3.1.01, 5]undecan-8-ol. Canonical SMILES: CC1CCC2C13CCC(C(C3)C2(C)C)(C)O. Density: 0.9479 g/cm³. Catalog: ACM77532.