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Eltrombopag
Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well. Group: Inhibitors. Alternative Names: Eltrombopag;3-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2-hydroxy-[1,1-biphenyl]-3-carboxylic acid;(1,1-Biphenyl)-3-carboxylic acid, 3-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene)hydrazino)-2-hydroxy-;Eltrombopag [inn];Promacta;Sb497115;Sb-497115;Unii-S56D65xj9g. CAS No. 496775-61-2. Molecular formula: C25H22N4O4. Mole weight: 442.47. Appearance: Solid. Purity: 0.9973. Canonical SMILES: O=C (C1=CC (C2=CC=CC (N/N=C3C (C)=NN (C4=CC=C (C)C (C)=C4)C/3=O)=C2O)=CC=C1)O. Density: 1.33. Catalog: ACM496775612.
Elvitegravir-d6(major)
Heterocyclic Organic Compound. Alternative Names: 6-[(3-Chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-3-quinolinecarboxylic Acid. CAS No. 1131640-69-1. Molecular formula: C23H17D6ClFNO5. Mole weight: 453.91. Appearance: Off-White to Pale Yellow Solid. Purity: 0.96. IUPACName: (S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylbutan-2-yl-1,1-d2. Catalog: ACM1131640691.
Elymoclavine
Elymoclavine is a chemical compound that has been shown to inhibit the enzyme activities of 5-HT2A receptors, which are involved in the transmission of nerve impulses. It also inhibits ergovaline and pergolide mesylate, two amines that are found in perennial ryegrass and have been shown to be toxic to humans. Elymoclavine is a synthetic pathway intermediate and belongs to the class of phytochemicals. It has been shown to have insecticidal activity against insects such as Drosophila melanogaster and Spodoptera littoralis. Elymoclavine has also been shown to have dopamine-like effects on human erythrocytes. Group: Other alkaloids. CAS No. 548-43-6. Molecular formula: C16H18N2O. Mole weight: 254.33 g/mol. Canonical SMILES: CN1CC (=C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34) CO. Catalog: ACM548436.
Emamectin Benzoate
Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated DNA damage and cell apoptosis. Emamectin Benzoate, a mixture of the natural Emamectin B1a benzoate and Emamectin B1b benzoate, has the main component of Emamectin B1a benzoate. Uses: Emamectin benzoate is usually found as a mixture of two forms, which is a cream coloured powder. it is non corrosive and stable, except that it is flammable and may explode in the presence of strong oxidising agents. emamectin benzoate is a pesticide which works by interfering with nerve impulses in the body. it is used in agricultural settings to control insects amongst vegetable crops such as ca. Group: Inhibitors. CAS No. 155569-91-8. Molecular formula: C56H81NO15 (emamectin B1a benzoate) + C55H79NO15 (emamectin B1b benzoate). Mole weight: 1008.24. Appearance: white to off-white yellowish powder. Purity: 0.95. Canonical SMILES: C[C@H]1O[C@@H] (O[C@@]2 ([H])[C@H] (C)O[C@@H] (O[C@] ([C@@H] (C)/C=C/C=C3CO[C@@]4 ([H])[C@]\3 (O)[C@H]5C=C (C)[C@H]4O) ([H])/C (C)=C/C[C@@H]6C[C@H] (OC5=O)C[C@]7 (C=C[C@H] (C)[C@@H] (C (C)C)O7)O6)C[C@@H]2OC)C[C@@H] (OC)[C@@H]1NC. C[C@H]8O[C@@H] (O[C@@]9 ([H])[C@H] (C)O[C@@H] (O[C@] ([C@@H] (C)/C=C/C=C%10CO[C@@]%
Emavusertib
Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. Group: Inhibitors. Alternative Names: CA-4948; CA 4948; CA4948; Emavusertib. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.51. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-N-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide. Canonical SMILES: O=C (C1=COC (C2=CC (C)=NC=C2)=N1)NC3=C (N4C[C@H] (O)CC4)N=C5C (OC (N6CCOCC6)=N5)=C3. Catalog: ACM1801344148.
Emodin
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Group: Inhibitors. Alternative Names: 1,3,8-trihydroxy-6-methylanthraqunone. CAS No. 518-82-1. Molecular formula: C15H10O5. Mole weight: 270.24. Appearance: Powder. Purity: 0.98. IUPACName: 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione. Canonical SMILES: CC1=CC2=C (C (=C1)O)C (=O)C3=C (C2=O)C=C (C=C3O)O. Density: 1.33 g/ml. Catalog: ACM518821-1.
Emodin-d4
Emodin-d4 is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Group: Inhibitors. Alternative Names: Emodin-d4;1,3,8-Trihydroxy-6-Methyl-9,10-anthracenedione-d4;1,6,8-Trihydroxy-3-Methylanthraquinone-d4;4,5,7-Trihydroxy-2-Methyl- anthraquinone-d4;Archin-d4;EModol-d4;Frangula EModin-d4;Frangulic Acid-d4. CAS No. 132796-52-2. Molecular formula: C15H10O5. Mole weight: 270.2369. Appearance: Brownish Solid. Purity: 0.96. IUPACName: 1,3,6,8-tetradeuterio-2,4,5-trihydroxy-7-methylanthracene-9,10-dione. Canonical SMILES: O=C1C2=C (O)C ([2H])=C (C)C ([2H])=C2C (C3=C ([2H])C (O)=C ([2H])C (O)=C31)=O. Catalog: ACM132796522.
Emtricitabine
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection. Group: Inhibitors. Alternative Names: SM-Q; 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1, 3-oxathiolan-5-yl)-(2r-cis)-2(1h)-pyrimidinone; (-)-BETA-2, 3-DIDEOXY-5-FLUORO-3-THIACYTIDINE; EMTRICITABINE; EMTRITABINE; FTC; FUMITREMORGIN C;EMTRICITABIN. CAS No. 143491-57-0. Molecular formula: C8H10FN3O3S. Mole weight: 247.25. Purity: 0.9994. Catalog: ACM143491570.
Emtricitabine-15N,d2
Emtricitabine-15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection. Group: 15n labeled compounds. Alternative Names: BW1592-15N,d2. CAS No. 2714436-53-8. Molecular formula: C8H8D2FN215NO3S. Mole weight: 250.25. IUPACName: 4-(15N)azanyl-1-[(2R,5S)-2-[dideuterio(hydroxy)methyl]-1,3-oxathiolan-5-yl]-5-fluoropyrimidin-2-one. Canonical SMILES: O=C1N (C=C (C ([15NH2])=N1)F)[C@@]2 ([H])O[C@H] (SC2)C ([2H]) ([2H])O. Catalog: ACM2714436538.
Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials. Group: Inhibitors. Alternative Names: HM30181; HM-30181; HM 30181; HM-30181 mesylate; Encequidar mesylate. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. Appearance: White solid powder. Purity: >98%. IUPACName: N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate. Canonical SMILES: O=C (NC1=CC (OC)=C (C=C1C2=NN (N=N2)C3=CC=C (C=C3)CCN4CC5=C (CC4)C=C (C (OC)=C5)OC)OC)C6=CC (C7=C (C=CC=C7)O6)=O. OS (=O) (C)=O. Catalog: ACM849675872.
Enfuvirtide
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide. Group: Inhibitors. Alternative Names: Enfuvirtide; T-2;Enfuvirtide Acetate (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitide(T-20);Pentafuside;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH{2};Enf. CAS No. 159519-65-0. Molecular formula: C204H301N51O64. Mole weight: 4491.9. Purity: >95%. Density: 1.59g/cm³. Catalog: ACM159519650.
Heterocyclic Organic Compound. Alternative Names: Enniatin, Enniatins, CID3084092, 11113-62-5. CAS No. 11113-62-5. Molecular formula: C33H57N3O9. Mole weight: 639.8. Appearance: White to off white powder. Purity: >95%. IUPACName: (3S,9S,15S)-4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone. Canonical SMILES: CC (C)C1C (=O)OC (C (=O)N (C (C (=O)OC (C (=O)N (C (C (=O)OC (C (=O)N1C)C (C)C)C (C)C)C)C (C)C)C (C)C)C)C (C)C. ECNumber: 215-737-5. Catalog: ACM11113625.
Enpatoran free base
Enpatoran, also known as M5049, is a novel selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity. M5049 was found to be potent in vivo as TLR7/8 inhibition efficaciously treated disease in several murine lupus models and, interestingly, was efficacious in a disease context in which TLR7/8 activity has not previously been considered a primary disease driver. Furthermore, M5049 had greater potency in disease models than expected based on its in vitro potency and pharmacokinetic/pharmacodynamic properties. Group: Inhibitors. Alternative Names: Enpatoran; M 5049; M5049; M-5049. CAS No. 2101938-42-3. Molecular formula: C16H15F3N4. Mole weight: 320.32. Appearance: Solid powder. Purity: >98%. IUPACName: 5-((3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl)quinoline-8-carbonitrile. Canonical SMILES: N[C@]1 ([H])C[C@] ([H]) (C (F) (F)F)CN (C2=CC=C (C#N)C3=C2C=CC=N3)C1. Catalog: ACM2101938423.
Enrofloxacin
Enrofloxacin (BAY Vp 2674) is an effective antibiotic with an MIC90 of 0.312 μg/mL forMycoplasma bovis. Group: Inhibitors. Alternative Names: 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-1-piperazinyl)-quinoline-3-carboxylic acid; Baytri; Enrofloxacin; ROFLOXACIN BASE; Enrofoxacin; Enrolfoxacin; bayvp2674; 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-1-piperazinyl)-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethylpiperazino)-quinoline-3-carboxylic acid; 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-7-(4-ethyl-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid; Enorfloxacin; cfpq. CAS No. 93106-60-6. Molecular formula: C19H22FN3O3. Mole weight: 359.39. Appearance: Pale Yellow Crystals. Purity: 95%+. IUPACName: 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylicacid. Canonical SMILES: CCN1CCN (CC1)C2=C (C=C3C (=C2)N (C=C (C3=O)C (=O)O)C4CC4)F. Density: 1.385g/cm³. ECNumber: 618-911-2. Catalog: ACM93106606.
Ensitrelvir (S-217622) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM). Group: Inhibitors. Alternative Names: 6-[(6-Chloro-2-methylindazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4-dione. CAS No. 2647530-73-0. Molecular formula: C22H17ClF3N9O2. Mole weight: 531.88. Appearance: Solid. Purity: 0.98. IUPACName: 6-[(6-chloro-2-methylindazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4-dione. Canonical SMILES: CN1C=C2C=C (C (=CC2=N1)Cl)NC3=NC (=O)N (C (=O)N3CC4=CC (=C (C=C4F)F)F)CC5=NN (C=N5)C. Catalog: ACM2647530730.
Ensitrelvir fumarate
Ensitrelvir, also known as S-217622, is an antiviral drug developed by Shionogi in partnership with Hokkaido University, which acts as an orally active 3C-like protease inhibitor for the treatment of COVID-19 infection. It is taken by mouth, and has been successfully tested against the recently emerged Omicron variant. It is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM). It became the first Japanese domestic pill to treat COVID-19, third to be regulatorally approved in Japan; in February 2022. Group: Inhibitors. Alternative Names: Ensitrelvir fumarate; S-217622; S 217622; S217622; Xocova. CAS No. 2757470-18-9. Molecular formula: C26H21ClF3N9O6. Mole weight: 647.96. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-6-((6-chloro-2-methyl-2H-indazol-5-yl)imino)-3-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)-1-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4-dione fumaric acid. Canonical SMILES: O=C (N (CC1=NN (C)C=N1)C (N/2)=O)N (CC3=CC (F)=C (F)C=C3F)C2=N\C4=CC5=CN (C)N=C5C=C4Cl. O=C (O)/C=C/C (O)=O. Catalog: ACM2757470189.
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kinases. PXDX-101 has been well tolerated in patients with advanced solid tumors. PXDX-101 is currently in clinical trials, and is being developed by Ignyta. Group: Inhibitors. Alternative Names: RXDX101; RXDX 101; RXDX-101; NMS E628; NMSE628; NMS-E628; Entrectinib. CAS No. 1108743-60-7. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. Appearance: Solid powder. Purity: >98%. IUPACName: N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide. Canonical SMILES: O=C (NC1=NNC2=C1C=C (CC3=CC (F)=CC (F)=C3)C=C2)C4=CC=C (N5CCN (C)CC5)C=C4NC6CCOCC6. Catalog: ACM1108743607.
Ent-rotigotine
Heterocyclic Organic Compound. Alternative Names: (6R)-. CAS No. 112835-48-0. Molecular formula: C19H25NOS. Mole weight: 315.47. Catalog: ACM112835480.
Enviomycin
Enviomycin (Tuberactinomycin N) is a antibacterial antibiotic. Enviomycin has been used to research chronic cavitary pulmonary tuberculosis. Group: Inhibitors. Alternative Names: Enviomycin;1,4,7,10,13-Pentaazacyclohexadecane, cyclic peptide deriv.;enviomucin;Tuberactinomycin N (8CI, 9CI);Viomycin, 1-[(3R,4R)-4-hydroxy-3,6-diaminohexanoic acid]-6-[L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)glycine]-, (R)-;N2-[(4R)-4-Hydroxy-L-. CAS No. 33103-22-9. Molecular formula: C25H43N13O10. Mole weight: 685.696. Purity: 0.96. IUPACName: 3, 6-diamino-N-[(6Z)-3-(2-amino-1, 4, 5, 6-tetrahydropyrimidin-6-yl)-6-[(carbamoylamino)methylidene]-9, 12-bis(hydroxymethyl)-2, 5, 8, 11, 14-pentaoxo-1, 4, 7, 10, 13-pentazacyclohexadec-15-yl]-4-hydroxyhexanamide. Density: 1.8g/cm³. Catalog: ACM33103229.
Eperezolid
Eperezolid is a bioavailable synthetic antimicrobial agent with spectra of activity against antibiotic-susceptible and -resistant gram-positive pathogens. Group: Others. Alternative Names: Eperezolid; PNU 100592; PNU-100592; PNU100592; U 100592; U-100592; U-100592. CAS No. 165800-04-4. Molecular formula: C18H20FN4O5. Mole weight: 391.38. Appearance: Solid powder. Purity: >98%. IUPACName: Acetamide, N-((3-(3-fluoro-4-(4-(hydroxyacetyl)-1-piperazynyl)phenyl)- 2-oxo-5-oxazolidinyl)methyl)-, (S)-. Canonical SMILES: CC (NC[C@H]1CN (C2=CC=C (C3C#[N]CCN3C (CO)=O)C (F)=C2)C (O1)=O)=O. Catalog: ACM165800044.
Epiblastin A
Epiblastin A is a Casein Kinase 1 (CK1) inhibitor. Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). Group: Inhibitors. Alternative Names: Epiblastin A; AUE. CAS No. 16470-02-3. Molecular formula: C12H10ClN7. Mole weight: 287.71. Appearance: Solid powder. Purity: >98%. IUPACName: 6-(3-Chloro-phenyl)-pteridine-2,4,7-triamine. Canonical SMILES: NC1=NC (N)=C2N=C (C3=CC=CC (Cl)=C3)C (N)=NC2=N1. Catalog: ACM16470023.
(-)-Epicatechin Gallate
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. Group: Inhibitors. Alternative Names: (2R)-2α-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3β,5,7-triol 3-(3,4,5-trihydroxybenzoate). CAS No. 1257-08-5. Molecular formula: C22H18O10. Mole weight: 442.37. Appearance: White powder. Purity: 0.98. IUPACName: [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate. Canonical SMILES: C1[C@H] ([C@H] (OC2=CC (=CC (=C21)O)O)C3=CC (=C (C=C3)O)O)OC (=O)C4=CC (=C (C (=C4)O)O)O. Density: 1.80±0.1 g/ml. Catalog: ACM1257085.
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion. Group: Inhibitors. CAS No. 111254-18-3. Molecular formula: C16H16O6. Mole weight: 304.29. Canonical SMILES: O[C@]1 ([C@@H] (C2=CC=C (O)C=C2OC1)O)CC3=CC (O)=C (C=C3)O. Catalog: ACM111254183.
Episilvestrol
Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Group: Inhibitors. Alternative Names: Episilvestrol. CAS No. 697235-39-5. Molecular formula: C34H38O13. Mole weight: 654.665 g/mol. Appearance: Solid powder. Purity: ≥98%. IUPACName: methyl (1R,2R,3S,3aR,8bS)-6-(((2S,3R,6R)-6-((S)-1,2-dihydroxyethyl)-3-methoxy-1,4-dioxan-2-yl)oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate. Canonical SMILES: O=C ([C@H] ([C@H]1C2=CC=CC=C2)[C@@H] (O)[C@]3 (O)[C@@]1 (C4=CC=C (OC)C=C4)OC5=CC (O[C@@H]6O[C@@H] ([C@@H] (O)CO)CO[C@H]6OC)=CC (OC)=C35)OC. Catalog: ACM697235395.
Epo
Heterocyclic Organic Compound. Alternative Names: ERYTHROPOIETIN RAT;EPO;erythropoietin from human urine*approx 100 units;Erythropoietin,from human urine;ERYTHROPOIETIN HUMAN, RECOMB. FROM CHO- CELLS, PGE W. 10 U;ERYTHROPOIETIN FROM HUMAN URINE*APPROX 5 00 UNITS PE;ERYTHROPOIETIN FROM HUMAN URINE*APPROX 100 UNITS PER;Erythropietin human. CAS No. 11096-26-7. Molecular formula: NULL. Appearance: lyophilized powder. Catalog: ACM11096267.
EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. EPZ011989 represents a powerful tool for the expanded exploration of EZH2 activity in biology. Inhibitors of the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2) may have significant therapeutic potential for the treatment of B cell lymphomas and other cancer indications. The ability of the scientific community to explore fully the spectrum of EZH2-associated pathobiology has been hampered by the lack of in vivo-active tool compounds for this enzyme. Group: Inhibitors. Alternative Names: EPZ011989; EPZ-011989; EPZ 011989. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. Appearance: Solid powder. Purity: >98%. IUPACName: N- ( (4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-3- (ethyl ( (1r, 4r)-4- ( (2-methoxyethyl) (methyl)amino)cyclohexyl)amino)-2-methyl-5- (3-morpholinoprop-1-yn-1-yl)benzamide. Canonical SMILES: O=C (NCC1=C (C)C=C (C)NC1=O)C2=CC (C#CCN3CCOCC3)=CC (N (CC)[C@H]4CC[C@H] (N (CCOC)C)CC4)=C2C. Catalog: ACM1598383404.
Erbium(3+):triacetate:tetrahydrate
Erbium Complexes. Alternative Names: Erbium, tris(acetato-κO)tetraaqua-. CAS No. 1137599-15-5. Molecular formula: C6H17ErO10. Mole weight: 416.45. Purity: 98%+. Catalog: ACM1137599155.
Erbium Aluminide
Erbium Aluminide is generally immediately available in most volumes. HHigh purity, submicron and nanopowder forms may be considered. Group: Er. CAS No. 12004-20-5. Molecular formula: ErAl2. Mole weight: 221g/mol. Appearance: solid. Catalog: ACM12004205.
Erbium Barium Copper Oxide
Erbium Barium Copper Oxide is a hHigh-TC superconducting ceramic in the family of rare-earth doped barium copper oxides (or barium cuprates). Group: Er. CAS No. 109457-23-0. Molecular formula: ErBa2Cu3Ox. Mole weight: 745g/mol. Appearance: White powder or sputtering target. Catalog: ACM109457230.
Atomic number of base material: 68 Erbium. Group: Micro/nanoelectronics. Alternative Names: Er(TMHD)3. CAS No. 35733-23-4. Molecular formula: Er(OCC(CH3)3CHCOC(CH3)3)3. Mole weight: 717.06. IUPACName: erbium;(E)-5-hydroxy-2,2,6,6-tetramethylhept-4-en-3-one. Canonical SMILES: CC (C) (C)C (=O)\C=C (/O[Er] (O\C (=C/C (=O)C (C) (C)C)C (C) (C)C)O\C (=C/C (=O)C (C) (C)C)C (C) (C)C)C (C) (C)C. Catalog: ACM35733234.
Erbium Oxalate
Erbium Oxalate, is an important colourant in glasses and porcelain enamel glazes. HHigh purity Erbium Oxalate is widely applied as dopant in making optical fibre and amplifier. It is particularly useful as an amplifier for fiber optic data transfer. Uses: Is an important colourant in glasses and porcelain enamel glazes. high purity erbium oxalate is widely applied as dopant in making optical fibre and amplifier. Group: Heterocyclic organic compound. CAS No. 30618-31-6. Molecular formula: Er2(C2O4)3.10H2O. Mole weight: 779g/mol. Appearance: Pink color. Density: :2,64g/mL. Catalog: ACM30618316.
Erbium Sulfide
Erbium Sulfide is a moderately water and acid soluble Erbium source for uses compatible with sulfates. Group: Heterocyclic organic compound. Alternative Names: ERBIUM SULFIDE;dierbium trisulphide;ERBIUM SULFIDE 99.9%;ERBIUM SULPHIDE;Erbium sulfide, min. 99% powder;Erbium sulfide, 99.9% (REO). CAS No. 12159-66-9. Molecular formula: Er2S3. Mole weight: 431g/mol. Appearance: Powder. Purity: 0.96. IUPACName: erbium(3+) trisulfide. Density: 6.07g/mL. Catalog: ACM12159669.
ERD-308
ERD-308 is a Highly Potent Proteolysis Targeting Chimera Degrader of Estrogen Receptor (ER) ERD-308 achieves DC50 (concentration causing 50% of protein degradation) values of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively, and induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines. Significantly, ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells. Group: Others. Alternative Names: ERD-308; ERD 308; ERD308. CAS No. 2320561-35-9. Molecular formula: C55H65N5O9S2. Mole weight: 1004.27. Appearance: Solid powder. Purity: >98%. IUPACName: (2S,4R)-1-((S)-2-(2-((5- (Ethyl (2- (4- (6-hydroxy-2- (4-hydroxyphenyl) benzo[b]thiophene-3-carbonyl) phenoxy) ethyl) -amino) pentyl) oxy) acetamido) -3, 3-dimethylbutanoyl) -4-hydroxy-N- ( (S) -1- (4- (4-methylthiazol-5-yl) phenyl) ethyl) pyrrolidine-2-carboxamide. Canonical SMILES: O=C ([C@H]1N (C ([C@@H] (NC (COCCCCCN (CC)CCOC2=CC=C (C (C3=C (C4=CC=C (O)C=C4)SC5=CC (O)=CC=C53)=O)C=C2)=O)C (C) (C)C)=O)C[C@H] (O)C1)N[C@H] (C6=CC=C (C7=C (C)N=CS7)C=C6)C. Catalog: ACM2320561359.
Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 18 nM. Group: Inhibitors. Alternative Names: (S)-3',4',5,7-Tetrahydroxyflavanone. CAS No. 552-58-9. Molecular formula: C12H21NO8S. Mole weight: 339.36. Appearance: White solid. Purity: 0.99. IUPACName: (2S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one. Canonical SMILES: C1C (OC2=CC (=CC (=C2C1=O)O)O)C3=CC (=C (C=C3)O)O. Density: 1.336±0.06 g/cm³. Catalog: ACM552589.
Eritoran
Eritoran is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection. Group: Inhibitors. Alternative Names: ERITORAN;3-O-Decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate);Eritoran [inn]. CAS No. 185955-34-4. Molecular formula: C66H122N2O19P2.4Na. Mole weight: 1401.59. Density: 1.14. Catalog: ACM185955344.
Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research. Group: Inhibitors. Alternative Names: abboticin; abomacetin; dotycin; em; emu; e-mycin; erycin; erycinum. CAS No. 114-07-8. Molecular formula: C37H67NO13. Mole weight: 733.93. Appearance: powder. Purity: 0.9986. Catalog: ACM114078.
Erythromycin a dihydrate
Erythromycin A dihydrate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin A dihydrate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin A dihydrate also exhibits antitumor and neuroprotective effect in different fields of research. Group: Inhibitors. CAS No. 59319-72-1. Molecular formula: C37H67NO13.H2O. Mole weight: 751.945. Catalog: ACM59319721.
Erythromycin Base
Heterocyclic Organic Compound. CAS No. 114-07-0. Catalog: ACM114070.
Erythromycin lactobionate
Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research. Group: Inhibitors. Alternative Names: Erythromycin lactobionate;Erythromycin lactobionate (200 mg). CAS No. 3847-29-8. Molecular formula: C37H67NO13.C12H22O12. Mole weight: 1092.22. Appearance: White to off-white powder. Purity: 0.98. Density: g/cm³. Catalog: ACM3847298.
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression. Group: Inhibitors. CAS No. 123748-68-5. Molecular formula: C55H86O24. Mole weight: 1131.3. Appearance: White powder. Purity: 0.98. IUPACName: (2S, 3S, 4S, 5R, 6R)-6-[[(3S, 4S, 4aR, 6aR, 6bS, 8R, 8aR, 9R, 10R, 12aS, 14aR, 14bR)-9-acetyloxy-8-hydroxy-4, 8a-bis(hydroxymethyl)-4, 6a, 6b, 11, 11, 14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1, 2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14, 14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3, 5-bis[[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid. Canonical SMILES: CC=C (C)C (=O)OC1C (C2 (C (CC1 (C)C)C3=CCC4C5 (CCC (C (C5CCC4 (C3 (CC2O)C)C) (C)CO)OC6C (C (C (C (O6)C (=O)O)OC7C (C (C (C (O7)CO)O)O)O)O)OC8C (C (C (C (O8)CO)O)O)O)C)CO)OC (=O)C. Catalog: ACM123748685.
Esermethole
Esermethole is an analytical method that is used for the separation of racemic oxindoles. It is a powerful tool that can be used to synthesize a wide range of compounds with various functional groups and enantiomers. It also has the ability to allylate amines, which are important in the synthesis of pharmaceuticals. Esermethole is an analytical method that can be used in the preparation of samples for analysis by NMR spectroscopy, gas chromatography, or mass spectrometry. The asymmetric synthesis process involves three steps: (1) reaction of an alcohol with sodium carbonate to produce a chiral alcohol; (2) reaction of the chiral alcohol with an alkyl halide to produce a chiral acid; and (3) condensation of the chiral acid with an amine to produce the desired product. Group: Indole alkaloids. CAS No. 65166-97-4. Canonical SMILES: C[C@@]12CCN ([C@@H]1N (C3=C2C=C (C=C3)OC)C)C. Catalog: ACM65166974.
EST64454 HCl
EST64454 is a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability in all species, linked to an adequate pharmacokinetic profile in rodents, and antinociceptive properties in the capsaicin and partial sciatic nerve ligation models in mice. Group: Antagonists. Alternative Names: EST64454 HCl; EST64454 hydrochloride; EST64454; EST-64454; EST 64454. CAS No. 1950569-11-5. Molecular formula: C18H23ClF2N4O2. Mole weight: 400.85. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethan-1-one hydrochloride. Canonical SMILES: CC (N1CCN (CCOCC2=NN (C3=CC=C (F)C (F)=C3)C=C2)CC1)=O. [H]Cl. Catalog: ACM1950569115.
Estramustine phosphate
Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer. Group: Inhibitors. CAS No. 4891-15-0. Molecular formula: C23H32Cl2NO6P. Mole weight: 520.38. Canonical SMILES: O=C (OC1=CC=C2[C@@]3 ([H])CC[C@]4 (C)[C@@H] (OP (O) (O)=O)CC[C@@]4 ([H])[C@]3 ([H])CCC2=C1)N (CCCl)CCCl. Catalog: ACM4891150.