BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| (±)10(11)-EDP Ethanolamide | (±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist. Synonyms: 10,11-EDP-EA; 10,11-EDP epoxide; 10,11-epoxy Docosapentaenoic Ethanolamide. Grades: ≥98%. CAS No. 2123484-71-7. Molecular formula: C24H37NO3. Mole weight: 387.56. |  |
| 10-DEBC hydrochloride | 10-DEBC hydrochloride is a selective and reversible Akt/PKB inhibitor suppressing the IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), and inhibiting downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. 10-DEBC hydrochloride inhibits cell growth (IC50 ~ 2-6 μM) and leads to apoptosis in rhabdomyosarcoma cells. Synonyms: 10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1); Akt Inhibitor X; 2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride; 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride; 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 925681-41-0. Molecular formula: C20H25N2OCl.HCl. Mole weight: 381.34. | |
| 10-Nitrolinoleate | 10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Alteratively, nitrolinoleates can act independently of NO/cGMP and PPARγ signaling to suppress neutrophil and macrophage functions. Synonyms: LNO2; 10-nitro-9,12-octadecadienoic acid. Grades: ≥95%. CAS No. 774603-04-2. Molecular formula: C18H31NO4. Mole weight: 325.4. | |
| 10-Nitrooleate | Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 μM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 μM. Uses: Anti-inflammatory agents. Synonyms: 9-Octadecenoic acid, 10-nitro-, (9E)-; (9E)-10-Nitro-9-octadecenoic acid; (E)-10-Nitro-octadec-9-enoic acid; CXA 10; IMR 261; 10-Nitro Oleic Acid; (9E)-10-nitrooctadecenoic acid; 10-nitro-9E-octadecenoic acid. Grades: ≥98%. CAS No. 875685-46-4. Molecular formula: C18H33NO4. Mole weight: 327.46. | |
| (10S)-Methyllycaconitine citrate | Methyllycaconitine is an alkaloid isolated from plants of of Delphinium (larkspurs) and acts as an α7-containing neuronal nicotinic acetylcholine receptor (nAChR) antagonist. Synonyms: MLA. Grades: ≥98%. CAS No. 351344-10-0. Molecular formula: C37H50N2O10·C6H8O7. Mole weight: 874.9. | |
| 1,1,1-trifluoro-3-(5-fluoro-2-methoxy-phenyl)-3-methyl-butan-2-one | A glucocorticoid receptor modulator. Synonyms: PD016802; 1,1,1-trifluoro-3-(5-fluoro-2-methoxyphenyl)-3-methylbutan-2-one; 1,1,1-Trifluoro-3-(5-fluoro-2-methoxy-phenyl)-3-methyl-butan-2-one; 1380656-10-9. Grades: 98%. Molecular formula: C12H12F4O2. Mole weight: 264.22. | |
| (±)-1-(1,2-Diphenylethyl)piperidine maleate | The meleate salt form of (±)-1-(1,2-Diphenylethyl)piperidine, which has been found to be a high affinity antagonist at the ion channel on the NMDA receptor. Synonyms: (+/-)-1-(1,2-Diphenylethyl)piperidine maleate. Grades: ≥98% by HPLC. CAS No. 207461-99-2. Molecular formula: C19H23N.C4H4O4. Mole weight: 381.47. | |
| 11-deoxy-16,16-dimethyl prostaglandin E2 | AY 24609 is an analogue of PGE2 and a selective EP2 and EP3 receptors agonist. It also inhibits gastric acid secretion and ulcer formation in rat. Synonyms: AY 24609; 11-deoxy-16,16-dimethyl PGE2; (Z)-7-[(1R,2R)-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 53658-98-3. Molecular formula: C22H36O4. Mole weight: 364.5. | |
| 11-Deoxy prostaglandin E1 | 11-Deoxy prostaglandin E1 is a synthetic analog of PGE1. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively. Uses: Anti-ulcer agents. Synonyms: 11-deoxy PGE1; 7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid. Grades: ≥96%. CAS No. 37786-00-8. Molecular formula: C20H34O4. Mole weight: 338.5. | |
| 1-(1-Naphthyl)piperazine hydrochloride | 1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively. Synonyms: Piperazine, 1-(1-naphthalenyl)-, hydrochloride (1:1); Piperazine, 1-(1-naphthalenyl)-, monohydrochloride; 1-(Naphthalen-1-yl)piperazine hydrochloride; 1-NP hydrochloride; 1-(1-Naphthyl) piperazine monohydrochloride. Grades: ≥98%. CAS No. 104113-71-5. Molecular formula: C14H16N2.HCl. Mole weight: 248.75. | |
| 11-Trans leukotriene C4 | 11-Trans leukotriene C4 is a C-11 double bond isomer of LTC4. Synonyms: 11-trans LTC4; Leucotriene C4. Grades: ≥97%. CAS No. 74841-69-3. Molecular formula: C30H47N3O9S. Mole weight: 625.8. | |
| 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride | Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current. Uses: Voltage-gated sodium channel blockers. Synonyms: 1-(2,6-dimethylphenoxy)propan-2-amine;hydrochloride. Grades: > 98 %. CAS No. 5370-1-4. Molecular formula: C11H18ClNO. Mole weight: 215.72. | |
| 12-Epi leukotriene B4 | 12-Epi leukotriene B4 is a leukotriene with less affinity than LTB4 at LTB4 receptors. Synonyms: 12-epi LTB4; 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid. Grades: ≥97%. CAS No. 83709-73-3. Molecular formula: C20H32O4. Mole weight: 336.5. | |
| 12(S)-HHTrE | 12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets. It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. Synonyms: 12(S)-HHT; 12-hydroxyheptadecatrienoic acid. Grades: ≥95%. CAS No. 54397-84-1. Molecular formula: C17H28O3. Mole weight: 280.4. | |
| 12(S)-HpETE | 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons6 and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex. Synonyms: 12-Hydroperoxyicosatetraenoate; (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid. Grades: ≥98%. CAS No. 71774-10-2. Molecular formula: C20H32O4. Mole weight: 336.5. | |
| 13,14-dihydro-15-keto prostaglandin D2 | 13,14-dihydro-15-keto prostaglandin D2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. It has been recently identified as a selective agonist for the DP2 receptor. Additionally, 13,14-dihydro-15-keto Prostaglandin D2 has been shown to inhibit ion flux in canine colonic mucosa preparation. Synonyms: 13,14-dihydro-15-keto PGD2; 11,15-dioxo-9S-hydroxy-5Z-prostenoic acid; (Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid. Grades: ≥95%. CAS No. 59894-07-4. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| 1,3-Dioleoyl-rac-glycerol | 1,3-Dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-3 positions. It activates protein kinase C (PKC) by approximately 30% when used at a concentration of 50 μM. It was used in the synthesis of amphiphilic gadolinium complexes as MRI contrast agents. Synonyms: 2-Hydroxy-1,3-propanediyl dioleate; Glycerol 1,3-dioleate; 1,3-Diolein. Grades: ≥98%. CAS No. 2465-32-9. Molecular formula: C39H72O5. Mole weight: 620.99. | |
| 1,3-Di-o-tolylguanidine | DTG has been found to be a σ-receptor agonist and is useful in studies of its interaction with dopamine drug. Uses: Anticonvulsants. Synonyms: 1,2-bis(2-methylphenyl)guanidine. Grades: ≥ 98 % by HPLC. CAS No. 97-39-2. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| 1,3-Dipalmitoyl-rac-glycerol | 1,3-Dipalmitoyl-rac-glycerol is a diacylglycerol that contains palmitic acid at the sn-1 and sn-3 positions. It activates protein kinase C α (PKCα) in vitro (Ka = 3.8 μM). 1,3-Dipalmitoyl-rac-glycerol (0.25-2 μM) inhibits apoptosis and production of reactive oxygen species (ROS) and pro-inflammatory mediators induced by oxygen-glucose deprivation and reperfusion (OGD/R) in SH-SY5Y neuroblastoma cells. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase. Synonyms: 1,3-Dipalmitin; Dipalmitin; 1,3-Dipalmitoyl-glycerol; Glyceryl 1,3-dipalmitate. Grades: ≥98%. CAS No. 502-52-3. Molecular formula: C35H68O5. Mole weight: 568.91. | |
| 1,3-Dipropyl-8-phenylxanthine | 1,3-Dipropyl-8-phenylxanthine has been found to be a selective A1 adenosine antagonist. Synonyms: 3,9-Dihydro-8-phenyl-1,3-dipropyl-1H-purine-2,6-dione. Grades: ≥98% by HPLC. CAS No. 85872-53-3. Molecular formula: C17H20N4O2. Mole weight: 312.37. | |
| 1,3-PBIT dihydrobromide | 1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability. 3-PBIT, also known as S,S'-(1,3-Phenylenebis(1,2-ethanediyl))bisisothiourea, is a potent and selective iNOS inhibitor. Synonyms: 2-[3- (2-carbamimidoylsulfanylethyl) phenyl]ethyl carbamimidothioate dihydrobromide. Grades: ≥98%. CAS No. 200716-66-1. Molecular formula: C12H18N4S2·2HBr. Mole weight: 444.2. | |
| 13(S)-HpOTrE(γ) | 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. Synonyms: 13(S)-Hydroperoxy-6Z,9Z,11E-octadecatrienoic acid; (6Z,9Z,11E,13S)-13-hydroperoxyoctadeca-6,9,11-trienoic acid. Grades: ≥98%. CAS No. 121107-97-9. Molecular formula: C18H30O4. Mole weight: 310.4. | |
| 13Z,16Z-Docosadienoic acid | 13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells. Synonyms: cis-13,16-Docosadienoic acid; (13Z,16Z)-docosa-13,16-dienoic acid. Grades: ≥98%. CAS No. 17735-98-7. Molecular formula: C22H40O2. Mole weight: 336.6. | |
| 1400W | 1400W is a selective inducible nitric oxide synthase (NOS) inhibitor (Ki = 7 nM, IC50=2.0 uM). By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury, acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor. Uses: A selective inducible nitric oxide synthase (inos) inhibitor. a long-acting human inos inhibitor possessing an ic50 value of 2.0um. Synonyms: N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE. Grades: >98%. CAS No. 180001-34-7. Molecular formula: C10H15N3. Mole weight: 177.251. | |
| 1400W dihydrochloride | 1400W is a selective inducible nitric oxide synthase (NOS) inhibitor (Ki=7nM). By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury, acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor. Uses: A selective inducible nitric oxide synthase (inos) inhibitor which has the potential for treatment of ischemia reperfusion injury,acute hypobaric hypoxia and tumor. Synonyms: N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride; 1400W HCl; 1400W hydrochloride; 1400W (hydrochloride). Grades: >98%. CAS No. 214358-33-5. Molecular formula: C10H17Cl2N3. Mole weight: 250.167. | |
| 14,15-Dehydro leukotriene B4 | 14,15-Dehydro leukotriene B4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. Synonyms: 14,15-dehydro LTB4; 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid. Grades: ≥97%. CAS No. 114616-11-4. Molecular formula: C20H30O4. Mole weight: 334.5. | |
| 1,4-DPCA | The pro-angiogenic factor HIF-1α is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH). It is a promotor of wound healing and tissue regeneration in mice. Synonyms: 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid. Grades: ≥98%. CAS No. 331830-20-7. Molecular formula: C13H8N2O3. Mole weight: 240.2. | |
| 1,4-PB-ITU dihydrobromide | The dihydrobromide salt form of 1,4-PB-ITU, a carbamimidoylsulfanyl derivative, has been found to be an iNOS and nNOS inhibitor that has poor membrane permeability in whole cells. Synonyms: 1,4-PB-ITU dihydrobromide; 1,4-PBIT dihydrobromide; EU-0100983; SCHEMBL2283156. Grades: 98%. CAS No. 157254-60-9. Molecular formula: C12H20Br2N4S2. Mole weight: 444.25. | |
| 15-Cyclohexyl pentanor prostaglandin F2α | 15-cyclohexyl pentanor PGF2α is an analog of PGF2α with resistance to 15-hydroxy PGDH metabolism. Synonyms: 15-cyclohexyl pentanor PGF2α; (Z)-7-[(1R,2R,3R,5S)-2-[(E,3S)-3-cyclohexyl-3-hydroxyprop-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid. Grades: ≥96%. CAS No. 58611-97-5. Molecular formula: C21H34O5. Mole weight: 366.5. | |
| 15-deoxy-Δ12,14-Prostaglandin J2 | 15-deoxy-Δ12,14-Prostaglandin J2 is a TRPA1 agonist and an endogenous PPARγ ligand that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM). Uses: Immunologic factors. Synonyms: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid. Grades: ≥95% by HPLC. CAS No. 87893-55-8. Molecular formula: C20H28O3. Mole weight: 316.44. | |
| 15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester | 15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 μM in a murine chimera system. Synonyms: 15-deoxy-Δ12,14-PGJ2-2-glycerol ester; 1,3-dihydroxypropan-2-yl (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoate. Grades: ≥98%. Molecular formula: C23H34O5. Mole weight: 390.5. | |
| 1,5-Dicaffeoylquinic acid | 1,3-Dicaffeoylquinic acid, a caffeoylquinic acid derivative found in artichoke, acts as an anti-hyperlipidemic agent and activates PI3K/Akt. Synonyms: (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid; 1,3-dicaffeoylquinic acid. Grades: >98%. CAS No. 19870-46-3. Molecular formula: C25H24O12. Mole weight: 516.45. | |
| (+)-15-epi Cloprostenol | Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analog and a potent FP receptor agonist. Synonyms: D-Cloprostenol; (+)-15(S)-Cloprostenol; 15S-Cloprostenol; 15-Epicloprostenol. Grades: ≥98%. CAS No. 54276-22-1. Molecular formula: C22H29ClO6. Mole weight: 424.9. | |
| 1,5-Isoquinolinediol | 1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. 1,5-Isoquinolinediol is also an inducible nitric oxide synthase (NOS2) inhibitor. 1,5-Isoquinolinediol significantly inhibited mitochondrial membrane potential loss, AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: 1,5-Dihydroxyisoquinoline; Isoquinoline-1,5-diol; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisocarbostyril. Grades: 99%. CAS No. 5154-2-9. Molecular formula: C9H7NO2. Mole weight: 161.16. | |
| 15-keto-17-phenyl trinor prostaglandin F2α | 15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Synonyms: 15-keto-17-phenyl trinor PGF2α; (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 949564-89-0. Molecular formula: C23H30O5. Mole weight: 386.5. | |
| 15-Keto prostaglandin E2 | 15-Keto prostaglandin E2 is a metabolite of PGE2 formed by 15-hydroxy PGDH. Synonyms: 15-keto PGE2; 15-Oxo-PGE2. Grades: ≥95%. CAS No. 26441-05-4. Molecular formula: C20H30O5. Mole weight: 350.5. | |
| 15-Lipoxygenase Inhibitor 1 | 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 μM. Synonyms: 15-LO Inhibitor 1; 4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine. Grades: ≥95%. CAS No. 928853-86-5. Molecular formula: C16H19N5S. Mole weight: 313.4. | |
| 15(R)-Prostaglandin D2 | Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor. 15(R)-15-methyl PGD2 is a surprisingly potent agonist at the DP2 receptor. Synonyms: 15(R)-PGD2; (5Z,9a,13E,15R)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid. Grades: ≥98%. CAS No. 59894-05-2. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| 15(R)-Prostaglandin E1 | 15(R)-PGE1 is the unnatural C-15 stereoisomer of PGE1. Synonyms: 15(R)-PGE1; 15-epi PGE1; 15-Epiprostaglandin E1. Grades: ≥95%. CAS No. 20897-91-0. Molecular formula: C20H34O5. Mole weight: 354.5. | |
| 15(R)-Prostaglandin F2α | 15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2&alpha. It has only 25% of the potency of PGF2α in hamster antifertility studies, which may be due to reduced affinity for FP receptors. Synonyms: 15-beta PGF2α; Prostaglandin F2α (15 beta epimer); 15-epi-PGF2alpha; 15R-Prostaglandin F2alpha. Grades: >99%. CAS No. 37658-84-7. Molecular formula: C20H34O5. Mole weight: 354.49. | |
| 15(S)-Fluprostenol | 15(S)-fluprostenol is less active as an FP agonist than 15(R)-fluprostenol. Synonyms: 16-(3-(Trifluoromethyl)phenoxy)-17,18,19,20-tetranor-2,3-cis-didehydro-pgf1-alpha; (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 54276-24-3. Molecular formula: C23H29F3O6. Mole weight: 458.5. | |
| 15(S)-HEDE | 15(S)-HEDE has been identified in psoriatic skin scale extracts (undetermined 15-OH stereochemistry) and inhibits 5-LO (5-lipoxygenase) with an IC50 of 26 μM. Synonyms: (15S)-15-hydroxyicosa-11,13-dienoic acid. Grades: ≥98%. CAS No. 92693-04-4. Molecular formula: C20H36O3. Mole weight: 324.5. | |
| 15(S)-HEPE | 15(S)-HEPE is a polyunsaturated fatty acid that is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. Synonyms: 15S-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid. Grades: ≥95%. CAS No. 86282-92-0. Molecular formula: C20H30O3. Mole weight: 318.45. | |
| 15(S)-HETE ethanolamide | Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC. 15(S)-HETE ethanolamide is less potent than AEA at the CB1 receptor (Ki of 600 versus 90 nM). 15(S)-HETE ethanolamide also inhibits fatty acid amide hydrolase. Synonyms: 15(S)-hydroxy-N-(2-hydroxyethyl)-5Z,8Z,11Z,13E-eicosatetraenamide; 15(S)-HAEA. Grades: >98%. CAS No. 161744-53-2. Molecular formula: C22H37NO3. Mole weight: 363.5. | |
| 15(S)-HETrE | 15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of DGLA. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. Synonyms: (15S)-15-hydroxyicosa-8,11,13-trienoic acid. Grades: ≥98%. CAS No. 92693-02-2. Molecular formula: C20H34O3. Mole weight: 322.5. | |
| 15(S)-HpETE | 15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. Synonyms: (S)-15-hpete; 15-Hydroperoxyicosatetraenoate; 15-Hydroperoxyeicosatetraenoate. Grades: ≥98%. CAS No. 70981-96-3. Molecular formula: C20H32O4. Mole weight: 336.5. | |
| 16,16-Dimethyl prostaglandin A1 | 16,16-Dimethyl prostaglandin A1 is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. Synonyms: 16,16-dimethyl PGA1; 7-[(1R,2S)-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopent-3-en-1-yl]heptanoic acid. Grades: ≥98%. CAS No. 41692-24-4. Molecular formula: C22H36O4. Mole weight: 364.5. | |
| 16,16-Dimethyl prostaglandin F2α | 16,16-Dimethyl prostaglandin F2α is a metabolically stable analog of PGF2&alpha. Synonyms: 16,16-dimethyl PGF2α; 16,16-Dimethylprostaglandin F2alpha. Grades: ≥98%. CAS No. 39746-23-1. Molecular formula: C22H38O5. Mole weight: 382.5. | |
| 16α-Hydroxy estrone | 16α-Hydroxy estrone is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. Synonyms: 16α-OHE1; 16a-Hydroxyestrone. Grades: ≥98%. CAS No. 566-76-7. Molecular formula: C18H22O3. Mole weight: 286.4. | |
| 16-Phenoxy prostaglandin F2α ethyl amide | 16-phenoxy PGF2α is a metabolically stable analog of PGF2&alpha. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2&alpha. Synonyms: 16-phenoxy PGF2α ethyl amide; Dechloro ethylcloprostenolamide. Grades: ≥98%. CAS No. 951319-59-8. Molecular formula: C24H35NO5. Mole weight: 417.5. | |
| 16-Phenoxy tetranor prostaglandin F2α isopropyl ester | 16-phenoxy tetranor PGF2α isopropyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α, which binds to the FP receptor on ovine luteal cells. Synonyms: 16-phenoxy tetranor PGF2α isopropyl ester; Phenoxybut-1-en-1-yl)cyclopentyl]hept-5-enoate. Grades: ≥95%. CAS No. 130209-78-8. Molecular formula: C25H36O6. Mole weight: 432.5. | |
| 16-Phenoxy tetranor prostaglandin F2α methyl amide | 16-phenoxy tetranor PGF2α methyl amide is a lipophilic analog of 16-phenoxy tetranor PGF2α, which binds to the FP receptor on ovine luteal cells. Synonyms: 16-phenoxy tetranor PGF2α methyl amide. Grades: ≥98%. Molecular formula: C23H33NO5. Mole weight: 403.5. | |
| 16-Phenoxy tetranor prostaglandin F2α methyl ester | 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α, which binds to the FP receptor on ovine luteal cells. Synonyms: 16-phenoxy tetranor PGF2α; methyl 7-[3,5-dihydroxy-2-(3-hydroxy-4-phenoxybut-1-enyl)cyclopentyl]hept-5-enoate. Grades: >98%. CAS No. 51638-90-5. Molecular formula: C23H32O6. Mole weight: 404.5. | |
| 16-Phenyl tetranor prostaglandin F2α | 16-phenyl tetranor PGF2α is a metabolically stable analog of PGF2&alpha. Synonyms: 16-phenyl tetranor PGF2α; 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-phenyl-1-buten-1-yl]cyclopentyl]-, (5Z)-; (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-4-phenyl-1-buten-1-yl]cyclopentyl]-5-heptenoic acid; 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-phenyl-1-butenyl]cyclopentyl]-, (5Z)-; 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-4-phenyl-1-butenyl)cyclopentyl]-, [1R-[1α(Z), 2β(1E, 3S*), 3α, 5α]]-; 9α,11α,15S-trihydroxy-16-phenyl-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid; (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-4-phenylbut-1-en-1-yl)cyclopentyl)hept-5-enoic acid; 16-Phenyl-17,18,19,20-tetranorprostaglandin F2&alpha. Grades: ≥95%. CAS No. 38315-48-9. Molecular formula: C22H30O5. Mole weight: 374.47. | |
| 17-AAG hydrochloride | 17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100-fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells. It has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively. It displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice compared with that from the normal tissues in vivo. Uses: 17-aag hydrochloride has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant t315i and e255k bcr-abl mutants. Synonyms: 17-AAG hydrochloride; 17 AAG hydrochloride; 17AAG hydrochloride; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate hydrochloride;Tanespimycin Hydrochloride;NSC 330507 Hydrochloride;CP 127374 Hydrochloride;17-(Allylamino)-17-desmethylgeldanamycin hydrochloride. Grades: >98%. CAS No. 911710-03-7. Molecular formula: C31H44ClN3O8. Mole weight: 622.15. | |
| 17-AG | An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Synonyms: 17 AG; 17AG; 17-AG; IPI493; IPI 493; IPI-493; NSC 255109; NSC255109; NSC-255109; 17-Aminogeldanamycin; 17-Amino Geldanamycin; 17-Aminodemethoxygeldanamycin; 17-Amino-17-demethoxygeldanamycin. Grades: >98%. CAS No. 64202-81-9. Molecular formula: C28H39N3O8. Mole weight: 545.62. | |
| 17β-Hydroxy wortmannin | 17β-Hydroxy wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). Synonyms: 17-Hydroxy wortmannin. Grades: ≥98%. CAS No. 58053-83-1. Molecular formula: C23H26O8. Mole weight: 430.4. | |
| 17-Chlorophenyl trinor prostaglandin F2α ethyl amide | 17-Chlorophenyl trinor prostaglandin F2α ethyl amide is an analog of Bimatoprost, which is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Synonyms: (5Z)-7-{(1R,2R,3R,5S)-2-[(1E,3S)-5-(3-Chlorophenyl)-3-hydroxy-1-penten-1-yl]-3,5-dihydroxycyclopentyl}-N-ethyl-5-heptenamide; Chlorophenyl Bimatoprost; 17-chlorophenyl trinor PGF2α ethyl amide; 5-Heptenamide, 7-[(1R,2R,3R,5S)-2-[(1E,3S)-5-(3-chlorophenyl)-3-hydroxy-1-penten-1-yl]-3,5-dihydroxycyclopentyl]-N-ethyl-, (5Z)-. Grades: ≥98%. Molecular formula: C25H36ClNO4. Mole weight: 450.01. | |
| 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid | 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. Synonyms: EFOX; 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA; 17-oxo-DHA; (4Z,7Z,10Z,13Z,15E,19Z)-17-Oxodocosahexaenoic acid. Grades: ≥90%. CAS No. 1233715-28-0. Molecular formula: C22H30O3. Mole weight: 342.5. | |
| 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid | Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. Synonyms: EFOX; 17-oxo-DPA; 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA; 17-keto-(7Z,10Z,13Z,15E,19Z)-docosapentaenoic acid. Grades: ≥95%. CAS No. 1233715-33-7. Molecular formula: C22H32O3. Mole weight: 344.5. | |
| 17-Phenoxy trinor prostaglandin F2α | 17-Phenoxy trinor prostaglandin F2α (17-phenoxy trinor PGF2α) is a novel analog of PGF2&alpha. Synonyms: 17-phenoxy trinor PGF2&alpha. Grades: >98%. Molecular formula: C23H32O6. Mole weight: 404.5. | |
| 17-Phenyl trinor prostaglandin E2 | 17-Phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist. Synonyms: 17-phenyl trinor PGE2; 17-phenyl-trinor-prostaglandin E2. Grades: ≥98%. CAS No. 38315-43-4. Molecular formula: C23H30O5. Mole weight: 386.5. | |
| 17-Phenyl trinor prostaglandin E2 ethyl amide | 17-Phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). Synonyms: 17-phenyl trinor PGE2 ethyl amide; (Z)-N-ethyl-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamide. Grades: ≥98%. CAS No. 1219032-20-8. Molecular formula: C25H35NO4. Mole weight: 413.6. | |
| 17-Phenyl trinor prostaglandin F2α 1,15-lactone | 17-Phenyl trinor prostaglandin F2α 1,15-lactone is a metabolically stable analog of PGF2α with potent FP receptor agonist activity and well known intraocular pressure-reducing effects. Synonyms: 17-phenyl trinor PGF2α 1,15-lactone. Grades: ≥98%. Molecular formula: C23H30O4. Mole weight: 370.5. | |
| 17-Trifluoromethylphenyl trinor prostaglandin F2α | 17-Trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. Synonyms: 17-trifluoromethylphenyl trinor PGF2α; (2R,3S,4R)-2-Ethyl-4-hydroxy-3-{(3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pent-1-en-1-yl}cyclopentyl. Grades: ≥98%. CAS No. 221246-34-0. Molecular formula: C24H31O5F3. Mole weight: 456.5. | |
| 1,8-Diacetoxy-3-carboxyanthraquinone | Cas No. 13739-02-1. | |
| 1,8-Dihydroxyanthraquinone | Cas No. 117-10-2. | |
| (±)19(20)-EDP Ethanolamide | (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). Synonyms: 19,20-DHEA epoxide; 19,20-epoxy docosapentaenoic acid ethanolamide; 19,20-EDP-EA; 19,20-EDP epoxide. Grades: ≥98%. CAS No. 2123485-34-5. Molecular formula: C24H37NO3. Mole weight: 387.55. | |
| 19(R)-Hydroxy prostaglandin E1 | 19(R)-Hydroxy prostaglandin E1 is the major prostaglandin found in the semen of primates. Synonyms: 19(R)-hydroxy PGE1; 7-[(2R)-2-[(7R)-3,7-dihydroxyoct-1-enyl]-3-hydroxy-5-oxocyclopentyl]heptanoic acid. Grades: ≥95%. CAS No. 64625-55-4. Molecular formula: C20H34O6. Mole weight: 370.5. | |
| 19(R)-Hydroxy prostaglandin E2 | 19(R)-Hydroxy-prostaglandin E2 is a PGE2 metabolite that acts as a potent smooth muscle relaxant and a selective EP2 receptor agonist, contrary to PGE2, which can activate a variety of prostanoid receptor types. Synonyms: 19(R)-hydroxy PGE2; 19(R)-OH PGE2; 19(R)-hydroxy Prostaglandin E2. Grades: ≥98%. CAS No. 64625-54-3. Molecular formula: C20H32O6. Mole weight: 368.5. | |
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