BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| 7ACC2 | 7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux. Synonyms: 7ACC2; 7 ACC2; 7-ACC2. Grades: >98%. CAS No. 1472624-85-3. Molecular formula: C18H15NO4. Mole weight: 309.32. |  |
| 7-BIO | 7-BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7-BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Synonyms: 7-Bromoindirubin-3'-oxime; 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. Grades: ≥99%. CAS No. 916440-85-2. Molecular formula: C16H10BrN3O2. Mole weight: 356.2. | |
| 7-Chlorokynurenic acid | 7-Chlorokynurenic acid is a water-soluble and very potent NMDA receptor antagonist acting at the strychnine-insensitive glycine binding site. It is also a potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is used in studies of schizophrenia and neuroprotection. Synonyms: 7CKA; 7-CKA; 7 CKA; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 18000-24-3. Molecular formula: C10H6ClNO3. Mole weight: 223.62. | |
| 7-Chlorokynurenic acid sodium salt | 7-Chlorokynurenic acid sodium salt is the sodium salt of 7-Chlorokynurenic acid, which is a water-soluble and very potent NMDA receptor antagonist acting at the strychnine-insensitive glycine binding site with IC50 value of 0.56 μM. It is also a potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is used in studies of schizophrenia and neuroprotection. Synonyms: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt. Grades: ≥98% by HPLC. CAS No. 1263094-00-3. Molecular formula: C10H5ClNNaO3. Mole weight: 245.59. | |
| 7-Hydroxy-DPAT hydrobromide | 7-Hydroxy-DPAT hydrobromide is a dopamine D3 receptor agonist (Ki = ~ 1, 10, 650 and ~ 5000 nM for D3, D2, D4 and D1 receptors, respectively). Synonyms: 2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide (1:1); 7-OH-DPAT Hydrobromide; (±)-7-Hydroxy-2-dipropylaminotetralin hydrobromide; 2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide; 7-Hydroxy(N,N-dipropyl-2-amino)tetralin hydrobromide; 7-Hydroxy-2-dipropylaminotetralin hydrobromide. Grades: ≥99% by HPLC. CAS No. 76135-30-3. Molecular formula: C16H25NO.HBr. Mole weight: 328.28. | |
| 7Keto-25-hydroxy cholesterol | 7-Keto-25-Hydroxy cholesterol is an oxysterol and a proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol. Synonyms: 25-hydroxy 7-keto cholesterol; 7-keto-25-hydroxycholesterol; cholest-5-ene-7-one-3ß,25-diol; 3β,25-dihydroxy-cholest-5-en-7-one. Grades: ≥95%. CAS No. 64907-23-9. Molecular formula: C27H44O3. Mole weight: 416.64. | |
| 7-NINA | 7-NINA is a non-selective NOS inhibitor. Synonyms: 7-NINA; 7 NINA; 7NINA; IN1195; 7-Nitroindazole sodium salt; IN-1195; IN 1195; IN1195. Grades: ≥98%. CAS No. 161467-34-1. Molecular formula: C7H4N3O2Na. Mole weight: 185.12. | |
| 7-Nitroindazole | 7-Nitroindazole is a nitric oxide synthase inhibitor. Synonyms: 7-Nitroindazole (7-NI);1H-Indazole, 7-nitro-; NSC 72843. Grades: ≥98% by HPLC. CAS No. 2942-42-9. Molecular formula: C7H5N3O2. Mole weight: 163.14. | |
| 8,11,14-Eicosatriynoic acid | 8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis as well as arachidonic acid induced platelet aggregation. Synonyms: 8,11,14-ETI; Eicosa-8,11,14-triynoic acid. Grades: ≥98%. CAS No. 34262-64-1. Molecular formula: C20H28O2. Mole weight: 300.4. | |
| 8,11-Eicosadiynoic acid | 8,11-Eicosadiynoic acid is an acetylenic fatty acid which inhibits arachidonic acid metabolism at several unrelated stages. 8,11-Eicosadiynoic acid inhibits the enzymes, arachidonoyl synthase, acyl-CoA synthase, Δ-5-desaturase, COX, and also arachidonic acid uptake by platelets. Synonyms: EDYA; Eicosa-8,11-diynoic acid. Grades: ≥95%. CAS No. 82073-91-4. Molecular formula: C20H32O2. Mole weight: 304.5. | |
| 8-Aminoadenine | 8-Aminoadenine is an adenine receptor agonist with Ki value of 0.0341 μM in HEK293 cells expressing an adenine binding site. It shows 190-fold increased potency at the human binding site over the rat adenine receptor. It inhibits adenine uptake and isoproterenol-stimulated cAMP accumulation. It may be used in the synthetic preparation of purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. It is important in regulating myocardial oxygen consumption and coronary blood flow. It may take part in inflammation and immune responses. Synonyms: 9H-Purine-6,8-diamine; 1H-Purine-6,8-diamine (9CI); 6,8-Diamino-purine (8CI); NSC 21698; NSC21698; NSC-21698. Grades: ≥98% by HPLC. CAS No. 28128-33-8. Molecular formula: C5H6N6. Mole weight: 150.14. | |
| 8-Cyclopentyl-1,3-dimethylxanthine | 8-Cyclopentyl-1,3-dimethylxanthine is a selective and high affinity adenosine A1 receptor antagonist. Its pKi value is 7.5-8. Synonyms: 8-Cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione; CPT; 8-Cyclopentyltheophylline. Grades: ≥99% by HPLC. CAS No. 35873-49-5. Molecular formula: C12H16N4O2. Mole weight: 248.28. | |
| 8-Hydroxy-5-nitroquinoline | Nitroxoline is a urinary antibacterial agent had proven to be very effective at combating biofilm infections. Uses: An antibiotic. Synonyms: 5-nitroquinolin-8-ol. Grades: ≥ 95 %. CAS No. 4008-48-4. Molecular formula: C9H6N2O3. Mole weight: 190.16. | |
| 8-Hydroxy-DPAT hydrobromide | 8-Hydroxy-DPAT hydrobromide is a selective 5-HT1A agonist with moderate affinity for 5-HT7 receptors (pKi = 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Synonyms: (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide. Grades: ≥98% by HPLC. CAS No. 76135-31-4. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| 8-Hydroxy-PIPAT oxalate | 8-Hydroxy-PIPAT oxalate is a high affinity 5-HT1A receptor agonist (Kd = 0.38 nM) that has the potential for the treatment of disorders of serotonin release. Synonyms: 1-Naphthalenol, 5,6,7,8-tetrahydro-7-[[(2E)-3-iodo-2-propen-1-yl]propylamino]-, ethanedioate (1:1); (RS)-trans-8-Hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin oxalate; (E)-7-((3-iodoallyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol oxalic acid; 7-{[(2E)-3-Iodo-2-propen-1-yl](propyl)amino}-5,6,7,8-tetrahydro-1-naphthalenol ethanedioate (1:1). Grades: ≥98% by HPLC. CAS No. 1451210-48-2. Molecular formula: C16H22INO.C2H2O4. Mole weight: 461.29. | |
| 8-Methoxy-2-aminotetraline hydrochloride | 8-Methoxy-2-Aminotetraline hydrochloride is a 5-HT1A agonist. Synonyms: 8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; 2-amino-8-methoxy-1,2,3,4-tetrahydronaphthalene HCl; Aminotetraline hydrochloride, 8-Methoxy-2-; 2-amino-8-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride. Grades: 98%. CAS No. 3880-76-0. Molecular formula: C11H15NO.HCl. Mole weight: 213.7. | |
| 8-M-PDOT | 8-M-PDOT is a melatonin receptor agonist, with 20-fold selective for the MT2 (vs MT1) subtype (pKi = 8.23 and 8.95 at human recombinant MT1 and MT2 receptors respectively). Synonyms: 8-Methoxy-2-propionamidotetralin. Grades: ≥99% by HPLC. CAS No. 134865-70-6. Molecular formula: C14H19NO2. Mole weight: 233.31. | |
| 8-OH-DPAT | 8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor and a 5-HT7 receptor agonist as well. Studies showed that it exhibited antidepressant, anxiolytic and other properties. Uses: Serotonin receptor agonists. Synonyms: 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; CHEMBL56; Ro-31-8220 in solution; 8-Hydroxy-DPAT. Grades: 99.03 %. CAS No. 78950-78-4. Molecular formula: C16H25NO. Mole weight: 247.38. | |
| (±)-8-Prenylnaringenin | (±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops. Synonyms: (±)-8-PN; 8-isopentenylnaringenin; Sophoraflavanone B. Grades: ≥98%. CAS No. 68682-02-0. Molecular formula: C20H20O5. Mole weight: 340.4. | |
| 8(S)-HETE | 8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. Synonyms: 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid. Grades: ≥98%. CAS No. 98462-03-4. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| 9,12-Octadecadiynoic acid | 9,12-Octadecadiynoic acid is an inhibitor of both COX and lipoxygenase. Synonyms: Ro 3-1314; 9a-12a-Octadecadiynoic acid. Grades: ≥98%. CAS No. 2012-14-8. Molecular formula: C18H28O2. Mole weight: 276.4. | |
| 9-Nitrooleate | 9-Nitrooleate is an activator of PPAR&gamma. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 μM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 μM. Synonyms: 9-nitro-9E-octadecenoic acid; 9-Nitro Oleic Acid; 9-Nitrooleic acid; 9-nitro-9-trans-Octadecenoic acid. Grades: ≥98%. CAS No. 875685-44-2. Molecular formula: C18H33NO4. Mole weight: 327.46. | |
| 9-Phenanthrol | 9-Phenanthrol, a cell permeable hydroxytricyclic derivative, functions as a selective inhibitor of TRPM4 (IC50 = 20 μM in HEK293 cells) and exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). 9-Phenanthrol was used to investigate C K-edge and O K-edge near-edge X-ray absorption fine structure (NEXAFS) spectra of single-wall carbon nanotubes. Uses: Protein kinase inhibitors. Synonyms: phenanthren-9-ol. CAS No. 484-17-3. Molecular formula: C14H10O. Mole weight: 194.23. | |
| (9R,10R)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene | (9R,10R)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene is a vital compound used in compound for its antioxidant properties. It plays a crucial role in studying oxidative stress-related diseases and conditions. It acts by neutralizing harmful free radicals and protecting cells from damage. Synonyms: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-[[(9R,10R)-10-hydroxy-9,10-dihydrophenanthren-9-yl]sulfanyl]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. Molecular formula: C24H27N3O7S. Mole weight: 501.6. | |
| 9(R)-HETE | 9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. Synonyms: 9R-hydroxy-5Z,7E,11Z,14Z-eicosatetraenoic acid. Grades: ≥98%. CAS No. 107656-14-4. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| 9(Z),11(E),13(E)-Octadecatrienoic acid ethyl ester | 9(Z),11(E),13(E)-Octadecatrienoic acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. Synonyms: α-ESA ethyl ester; Ethyl α-eleostearate; 9Z,11E,13E-Octadecatrienoic acid ethyl ester. Grades: ≥98%. CAS No. 42021-86-3. Molecular formula: C20H34O2. Mole weight: 306.5. | |
| 9(Z),11(E),13(E)-Octadecatrienoic acid methyl ester | 9Z,11E,13E-Octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. Synonyms: α-ESA methyl ester; Methyl α-eleostearate. Grades: ≥98%. CAS No. 4175-47-7. Molecular formula: C19H32O2. Mole weight: 292.5. | |
| (±)-AC 7954 hydrochloride | (±)-AC 7954 hydrochloride is a non-peptide urotensin-II (UT) receptor agonist. Synonyms: (±)-AC 7954 hydrochloride; (±)-AC7954 hydrochloride; (±)-AC-7954 hydrochloride ;(±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride. Grades: ≥98% by HPLC. CAS No. 477313-09-0. Molecular formula: C19H20ClNO2.HCl. Mole weight: 366.28. | |
| (±)-Acetylcarnitine chloride | (±)-Acetylcarnitine chloride is a weak cholinergic receptor agonist. It is used as an important intermediate in lipid metabolism. Synonyms: Acetyl-DL-carnitine hydrochloride; Acetyl-L-carnitine hydrochloride; O-Acetyl-L-carnitine hydrochloride; O-Acetyl-L-carnitine HCl. CAS No. 2504-11-2. Molecular formula: C9H18ClNO4. Mole weight: 239.70. | |
| (±)-ADX 71743 | (±)-ADX 71743 has been found to be a negative allosteric modulator at mGlu7 and is brain penetrant. Synonyms: ADX71743; ADX 71743; ADX-71743; 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone. Grades: ≥98% by HPLC. CAS No. 1431641-29-0. Molecular formula: C17H19NO2. Mole weight: 269.34. | |
| (+)-AJ 76 hydrochloride | The hydrochloride salt form of (+)-AJ 76, which is a dopamine receptor antagonist. Synonyms: (+)-AJ 76 hydrochloride; (+)-AJ76 hydrochloride; (+)-AJ-76 hydrochloride; (1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralin hydrochloride. Grades: ≥95% by HPLC. CAS No. 85378-82-1. Molecular formula: C15H23NO.HCl. Mole weight: 269.81. | |
| [Ala11,D-Leu15]-Orexin B | [Ala11,D-Leu15]-Orexin B is a selective OX2 receptor agonist with EC50 values are 0.13nM for human OX2. Grades: ≥95% by HPLC. CAS No. 532932-99-3. Molecular formula: C120H206N44O35S. Mole weight: 2857.28. | |
| (Ala1)-PAR4 (1-6) amide (mouse) trifluoroacetate salt | (Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively). Synonyms: AY-NH2; AYPGKF-NH2; H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2; PAR4-AP; Proteinase-Activated Receptor 4 Activating Peptide; L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide trifluoroacetate salt. Grades: ≥95%. Molecular formula: C34H48N8O7·xCF3COOH. Mole weight: 680.79. | |
| (Ala1)-PAR4 (1-6) (mouse) trifluoroacetate salt | (Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60. Synonyms: H-Ala-Tyr-Pro-Gly-Lys-Phe-OH; L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine trifluoroacetate salt. Grades: ≥95%. Molecular formula: C34H47N7O8·xCF3COOH. Mole weight: 681.78. | |
| α1 adrenoceptor-MO-1 | An S enantiomer which has affinity at alpha 1 adrenergic receptor. Synonyms: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[3-[(2S)-4-(3-chlorophenyl)-2-methyl-1-piperazinyl]propyl]-. CAS No. 161905-64-2. Molecular formula: C20H24ClN5O. Mole weight: 385.89. | |
| αβ-methylene ATP | αβ-methylene ATP, a phosphonic analog of ATP, is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 μM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors. αβ-methylene ATP also appears to act as an antagonist against endogenously released adenine nucleosides and nucleotides. Synonyms: α,β-Methyleneadenosine 5'-triphosphate trisodium salt; α,β-Methyleneadenosine 5'-triphosphate trisodium salt; alpha,beta-methylene Adenosine 5'-triphosphate (sodium salt). Grades: ≥98% by HPLC. CAS No. 1343364-54-4. Molecular formula: C11H15N5Na3O12P3. Mole weight: 571.15. | |
| α-Bungarotoxin | α-Bungarotoxin, a kind of neurotoxin, has been found to be a nAChRs inhibitor. Grades: ≥95% by HPLC. CAS No. 11032-79-4. Molecular formula: C338H529N97O105S11. Mole weight: 7984.14. | |
| α-Conotoxin ImI | α-Conotoxin ImI is a nicotinic acetylcholine receptor ligand isolated from the snail Conus imperialis. It shows selectivity for homomeric α7 and α9 receptors with IC50 values of 220 and 1800 nM respectively, but shows no effect on α2β2, α2β4, α3β2, α3β3, α4β2 and α4β4 subunit combinations. It mainly acts as an antagonist in central nervous system. It was sold under license for Cognetix for research purposes only. Synonyms: alpha-Ctx-imi. CAS No. 156467-85-5. Molecular formula: C52H78N20O15S4. Mole weight: 1351.60. | |
| α-Conotoxin PIA | α-Conotoxin PIA is a nicotinic acetylcholine receptor antagonist. It is selective for α6-containing nicotinic receptors. It can discriminate between the closely related α6 and α3 subunits. It was sold under license for Cognetix for research purposes only. CAS No. 669050-68-4. Molecular formula: C79H125N27O25S4. Mole weight: 1981.30. | |
| α-Cyano-4-hydroxycinnamic acid | CHC is a monocarboxylic acid transport (MCT) inhibitor, displaying antitumoral and antiangiogenic activity in gliomas in vivo. It decreases glycolytic metabolism, migration and invasion in U251 cells, enhances the effect of temozolomide. Synonyms: (E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid. Grades: ≥ 98 % by HPLC. CAS No. 28166-41-8. Molecular formula: C10H7NO3. Mole weight: 189.17. | |
| α-Guanidinoglutaric acid | α-Guanidinoglutaric acid is a linear mixed-type inhibitor of nNOS with Ki value of 2.69 μM. Synonyms: GGA; N-Amidino-L-glutamate; (S)-(-)-2-Guanidinoglutaric acid; alpha-guanidinoglutaric acid. Grades: ≥98%. CAS No. 73477-53-9. Molecular formula: C6H11N3O4. Mole weight: 189.2. | |
| α-helical CRF 9-41 | α-helical CRF 9-41 has been found to be a corticotropin-releasing factor receptor antagonist. Synonyms: Corticotropin-releasing factor (human), 1-de-L-serine-2-de-L-glutamicacid-3-de-L-glutamicacid-4-de-L-proline-5-de-L-proline-6-de-L-isoleucine-7-de-L-serine-8-de-L-leucine-18-L-methionine-23-L-lysine-27-L-glutamic acid-29-L-glutamicacid-32-L-alanine-33-L-leucine-36-L-leucine-38-L-leucine-40-L-glutamicacid-41-L-alaninamide-; CHEMBL526149. Grades: ≥95% by HPLC. CAS No. 90880-23-2. Molecular formula: C166H274N46O53S2. Mole weight: 3827.00. | |
| α-Hydroxy farnesyl phosphonic acid | α-Hydroxy farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). Synonyms: Hydroxyfarnesyl phosphate; [(2E,6E)-1-hydroxy-3,7,11-trimethyldodeca-2,6,10-trienyl]phosphonic acid. Grades: ≥98%. CAS No. 148796-53-6. Molecular formula: C15H27O4P. Mole weight: 302.4. | |
| α-Methyl-5-hydroxytryptamine maleate | α-Methyl-5-hydroxytryptamine maleate, a salt of α-Methylserotonin maleate, is a 5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively. It is used for forskolin-free cAMP assay for Gi-coupled receptors. Synonyms: 1H-Indol-5-ol, 3-(2-aminopropyl)-, (2Z)-2-butenedioate (1:1); 1H-Indol-5-ol, 3-(2-aminopropyl)-, (Z)-2-butenedioate (1:1) (salt); Indol-5-ol, 3-(2-aminopropyl)-, maleate; 2-Methyl-5-hydroxytryptamine maleate; 5-Hydroxy-α-methyltryptamine maleate; α-Methylserotonin maleate. Grades: ≥98% by HPLC. CAS No. 97469-12-0. Molecular formula: C11H14N2O.C4H4O4. Mole weight: 306.32. | |
| (±)-AMG 487 | Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Synonyms: N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide. Grades: ≥98% by HPLC. CAS No. 947536-03-0. Molecular formula: C32H28F3N5O4. Mole weight: 603.59. | |
| (+)-Anabasine hydrochloride | (+)-Anabasine hydrochloride is a nicotine alkaloid present in tobacco products. It is a high affinity neuronal nicotinic ACh receptor partial agonist with Ki values of 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively. It also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro. It is used as an indicator of smoking or tobacco use. Synonyms: (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride. Grades: ≥99% by HPLC. CAS No. 53912-89-3. Molecular formula: C10H15N2Cl. Mole weight: 198.69. | |
| (±)-Anatoxin A fumarate | (±)-Anatoxin A fumarate is a secondary, bicyclic amine alkaloid isolated from the blue-green alga A. aquae. It has cyanotoxin with acute neurotoxicity and could cause loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis. It displays high affinity for nicotinic acetylcholine receptors with Kd value of 0.1-0.2 μM. It binds to α4β2- and α7-type nicotinic receptors with Ki values of 1.3 nM and 1.8 μM, respectively. It stimulates [3H]-dopamine release from striatal synaptosomes with an EC50 value of 134 nM. Synonyms: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate; rac-Anatoxin A Fumarate; 1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone 2-Butenedioate. Grades: ≥96% by HPLC. CAS No. 1219922-30-1. Molecular formula: C14H19NO5. Mole weight: 281.31. | |
| (+)-Apogossypol | (+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins, binding and inhibiting Bcl-2 and Bcl-X(L) with high affinity and induces apoptosis of tumor cell lines. Uses: A potent inhibitor of bcl-2 family proteins. Synonyms: (R)-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexaol; methanol;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol; Apogossypol. Grades: ≥95%. CAS No. 66389-74-0. Molecular formula: C29H34O7. Mole weight: 494.58. | |
| [Arg14,Lys15]Nociceptin | [Arg14,Lys15]Nociceptin behaves as a highly potent agonist of the OP(4) receptor (EC50 = 1 nM) and is able to produce long-lasting effects in vivo, compared with the natural ligand NC. It exhibits > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Synonyms: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-OH; [Arg(14),Lys(15)]NC. CAS No. 236098-40-1. Molecular formula: C82H137N31O22. Mole weight: 1909.18. | |
| (-)-Azasetron hydrochloride | The (-)-enantiomer of Azasetron hydrochloride, which is a selective 5-HT3 antagonist. Grades: 99%. CAS No. 123040-96-0. Molecular formula: C17H20ClN3O3.HCl. Mole weight: 386.27. | |
| (+)-Azasetron hydrochloride | The (+)-enantiomer of Azasetron hydrochloride, which is a selective 5-HT3 antagonist. Uses: Antiemetics. Synonyms: azasetron hydrochloride; 123040-16-4; Azasetron HCl; 123040-69-7; Serotone; Y-25130 hydrochloride; 141922-90-9; Azasetron (hydrochloride); AZASETRONHYDROCHLORIDE; Azasetron hydrochloride [JAN]; D-erythro-Sphingosine (Brain, Porcine); 123040-93-7; 477243-03-1; 123040-96-0; 2BSS7XL60S; 123040-94-8; Y-25130 HCl; 2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, hydrochloride (1:1); N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide; hydrochloride; 6-chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide hydrochloride; Azasetron hydrochloride (JAN); Y-25130; 2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-,monohydrochloride, (+)-; 2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-,monohydrochloride,n. Grades: 99%. CAS No. 123040-94-8. Molecular formula: C17H20ClN3O3.HCl. Mole weight: 386.27. | |
| B07 hydrochloride | B07 hydrochloride is a CCR5 antagonist. Synonyms: B-07 hydrochloride; B 07 hydrochloride; B07 HCl; B-07 HCl; B 07 HCl. CAS No. 1260629-43-3. Molecular formula: C29H40Cl3FN4O2. Mole weight: 600.22. | |
| B2 | B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). B2 promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. B2 prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. Synonyms: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline; CPNQ. Grades: ≥98% by HPLC. CAS No. 115687-05-3. Molecular formula: C20H17ClN4O3. Mole weight: 396.83. | |
| B220 | B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV). Synonyms: 112228-65-6|B220|6H-Indolo(2,3-b)quinoxaline-6-ethanamine, N,N,2,3-tetramethyl-|2-(2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-N,N-dimethylethanamine|6H-Indolo[2,3-b]quinoxaline-6-ethanamine, N, N, 2, 3-tetra methyl -|Oprea1_679137|CHEMBL456589|SCHEMBL1 581068|ZINC24937|DTXSID40920692|9-OH-B220|NSC811922|NSC-811922|HY-100272|B 220|B-220|CS-0018424|2,3-dimethyl-6(2-dimethylaminoethyl)-6h-indolo-(2,3-b)quinoxaline|2,3-Dimethyl-N,N-dimethylaminoethyl-5H-indolo(2,3-b)quinoxaline|N,N,2,3-Tetramethyl-6H-indolo[2,3-b]quinoxaline-6-ethane-1-amine|2-(2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-N,N-dimethyl-ethanamine|2,3-Dimethyl-6-(dimethylaminoethyl)-9-hydroxy-6H-indolo-(2,3-b)quinoxaline|2-(2,3-Dimethyl-6H-indolo[2,3-b]quinoxalin-6-yl)-N,N-dimethylethan-1-amine|112229-05-7. Grades: ≥99.0%. CAS No. 112228-65-6. Molecular formula: C20H22N4. Mole weight: 318.42. | |
| BA-53038B | BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly in a distinct manner, with an EC50 value of 3.32 μM. Synonyms: BA-53038B|2306195-65-1|HY-114314|CS-0082064|N-(3-Chlorophenyl)bicyclo[4.1.0]heptane-7-carboxamide. Grades: 98.10%. CAS No. 2306195-65-1. Molecular formula: C14H16ClNO. Mole weight: 249.74. | |
| BACE-1 Inhibitor | BACE-1 Inhibitor is a potent, selective and cell-permeable inhibitor of human β-secretase (BACE-1) binding to the active site of BACE-1. It inhibits secretion of amyloid-β (Aβ) precursor protein (APP; IC50 = 29 nM) in HEK293T cells and also suppresses formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively). Synonyms: BACE-1 Inhibitor; BACE 1 Inhibitor; BACE1 Inhibitor; Beta-Secretase Inhibitor IV; β-Secretase Inhibitor IV; N1-[(1S,2R)-3-(Cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-N3-[(1R)-1-phenylethyl]-1,3-benzenedicarboxamide; Axon 1125. Grades: 98%. CAS No. 797035-11-1. Molecular formula: C31H38N4O5S. Mole weight: 578.72. | |
| Bafetinib | Bafetinib, also known as INNO-406, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). Synonyms: INNO406; INNO-406; INNO 406; NS187; NS-187; NS 187; Bafetinib. Grades: 0.98. CAS No. 859212-16-1. Molecular formula: C30H31F3N8O. Mole weight: 576.61. | |
| Balaglitazone | The Rs for the separations were 3.5 for balaglitazone enantiomers, 3.5 for pioglitazone enantiomers, and 3.7 for rosiglitazone. The squared correlation coefficients (r2) were found to be 0.999 for all three compounds. Balaglitazone treated groups shown significantly reduce of HbA1c (%), FSG (mmol/L), postprandial glucose as comparison to pioglitazone. Balaglitazone 10 mg and 20 mg show the similar magnitudes of the effects which comparable to the effects seen in the pioglitazone 45 mg group. The incidence of fluid retention and fat accumulation fewer than those observed with pioglitazone 45 mg. Sixty male dio induced obese rats were divided into five categories: vehicle, pioglitazone 10 mg/kg, pioglitazone 30 mg/kg, balaglitazone 5 mg/kg, balaglitazone 10 mg/kg. At day -7, 21 and 42 fasting serum samples were collected and whole body tissue composition was evaluated by MR scanning. Synonyms: DRF-2593; NN-2344; DRF2593; NN2344; DRF 2593; NN 2344. Grades: >98%. CAS No. 199113-98-9. Molecular formula: C20H17N3O4S. Mole weight: 395.43. | |
| Balapiravir | Balapiravir is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. It is the tri-isobutyrate ester prodrug of R1479 under clinical development to improve exposure of R1479 upon oral administration. It was discontinued for safety reasons in 28-36% of patients and the percentage of patients with serious adverse events was dose related. Synonyms: R1626; R-1626; R 1626; RO4588161; RO-4588161; RO 4588161; Balapiravir. Grades: >98%. CAS No. 690270-29-2. Molecular formula: C21H30N6O8. Mole weight: 494.5. | |
| Balicatib | The cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage with balicatib at 0, 3, 10, and 50 mg/kg for 18 months (groups O, L, M, H, respectively). Approximately 1 month after treatment initiation, the 50 mg/kg dose was decreased to 30 mg/kg. Twenty animals underwent sham-ovariectomies (group S). Bone mass was measured at 3-6 month intervals. At 18 months, vertebra and femur were collected for histomorphometry. Synonyms: AAE581; AAE-581; AAE 581. Grades: 0.98. CAS No. 354813-19-7. Molecular formula: C23H33N5O2. Mole weight: 411.54. | |
| BAM7 | BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM. Synonyms: BAM 7; BAM-7; BAM7. Grades: >98%. CAS No. 331244-89-4. Molecular formula: C21H19N5O2S. Mole weight: 405.47. | |
| Bambuterol | Bambuterol is a long acting beta-adrenoceptor agonist (LABA) and is used in the treatment of asthma. It is an ester prodrug of the ß2-adrenergic agonist terbutaline. lt is contraindicated in pregnancy and in people with seriously impaired liver function. It can be used by people with renal impairment. It can prolong the time of parent drug action. It has a strong role in bronchial dilation and used for obstructive airway diseases, such as bronchial asthma, chronic bronchitis, tremor and cardiac side effects. It has the adverse effects, including fatigue, nausea, palpitations, headache, dizziness and tremor. lt was developed by the Astra company and has been listed in 1987. Uses: Bambuterol is used in the treatment of asthma. it can prolong the time of parent drug action. it has a strong role in bronchial dilation and used for obstructive airway diseases, such as bronchial asthma, chronic bronchitis, tremor and cardiac side effects. Synonyms: [3-(Dimethylcarbamoyloxy)-5-[1-hydroxy-2-(tert-butylamino)ethyl]phenyl]N,N-dimethylcarbamate;5-[2-(ter-Butylamino)-1-hydroxyethyl]-1,3-phenylene bis(dimethylcarbamate); Bis(dimethylcarbamic acid)5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester;[3-[2-(tert-butylamino)-1-hydroxy-ethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate;N,N-dimethylcarbamic acid [3-[2-(tert-butylamino)-1-hydroxy-ethyl]-5-(dimethylcarbamoyloxy)phenyl] ester; Bambec; Bambuterolum; Oxeol; Bambuterolum. Grades: >98%. CAS No. 81732-65-2. Molecular formula: C18H29N3O5. Mole weight: 367.44. | |
| Bambuterol HCl | Bambuterol is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma. Synonyms: Bambuterol Hydrochloride; UNII-Y1850G1OVC; Bambuterol HCl; CHEBI:59167;DSSTox_CID_25515. Grades: >98%. CAS No. 81732-46-9. Molecular formula: C18H30ClN3O5. Mole weight: 403.9. | |
| BAN ORL 24 | BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonist and could be used to restrain the reduction of locomotor motions with brain permeability. IC50: 0.27 nM. Synonyms: Banyu Compound-24; CHEMBL201945; (R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-1-benzylpyrrolidine-2-carboxamide; C-24. CAS No. 475150-69-7. Molecular formula: C27H35N3O2. Mole weight: 433.594. | |
| BAN ORL 24 dihydrochloride | BAN ORL 24 dihydrochloride is a hydrochloride salt form of BAN ORL 24. BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonist and could be used to restrain the reduction of locomotor motions with brain permeability. IC50: 0.27 nM. Synonyms: BAN ORL 24 diHCl; BAN ORL 24 HCl; (2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide dihydrochloride. CAS No. 1401463-54-4. Molecular formula: C27H37Cl2N3O2. Mole weight: 506.512. | |
| Banoxantrone D12 | Cas No. 1562067-05-3. | |
| Banoxantrone D12 dihydrochloride | Cas No. 1562066-98-1. | |
| Banoxantrone dihydrochloride | Banoxantrone dihydrochloride, a bioreductive prodrug, can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor, and exhibits little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Uses: Antineoplastic agents. Synonyms: 2-[[4-[2-[dimethyl (oxido)azaniumyl]ethylamino]-5, 8-dihydroxy-9, 10-dioxoanthracen-1-yl]amino]-N, N-dimethylethanamine oxide;dihydrochloride; UNII-658876KMFP; Banoxantrone (dihydrochloride). CAS No. 252979-56-9. Molecular formula: C22H30Cl2N4O6. Mole weight: 517.4. | |
| b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal inhibition on recombinant and cytosolic nonproteasomal cysteine deubiquitinases. Synonyms: b-AP15; b-AP15; b-AP-15; USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. Grades: >98%. CAS No. 1009817-63-3. Molecular formula: C22H17N3O6. Mole weight: 419.39. | |
| Barasertib | Barasertib is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Synonyms: AZD1152; AZD-1152; AZD 1152; Barasertib. CAS No. 722543-31-9. Molecular formula: C26H31FN7O6P. Mole weight: 587.54. | |
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