BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| β -? [ [ [4, ?5-Dihydro-?5-? [2-? (1H-?imidazol-?2-?ylamino) ?ethyl] ?-?3-?isoxazolyl] ?carbonyl] ?amino] ?-?3, ?4-?dihydro-?γ -?oxo-2 (1H) ?-?Isoquinolinebutanoic Acid | β-[[[4,?5-Dihydro-5-[2-(1H-imidazol-2-ylamino)?ethyl]?-3-isoxazolyl]?carbonyl]?amino]?-3,?4-dihydro-γ-oxo-2(1H)?-Isoquinolinebutanoic Acid is a derivative of isoxazole, which exhibits potential antagonistic activity for integrin receptor. Synonyms: 3-(5-(2-((1H-Imidazol-2-yl)amino)ethyl)-4,5-dihydroisoxazole-3-carboxamido)-4-(3,4-dihydroisoquinolin-2(1H)-yl)-4-oxobutanoic Acid. CAS No. 1230487-85-0. Molecular formula: C22H26N6O5. Mole weight: 454.48. |  |
| β-Acetyl-boswellic acid | Cas No. 5968-70-7. | |
| β-CCB | β-CCB is an endogenous benzodiazepine binding inhibitor with proconvulsant and anxiogenic properties. Synonyms: Butyl β-carboline-3-carboxylate; beta-CCB; Butyl 9H-pyrido[3,4-b]indole-3-carboxylate. Grades: ≥99% by HPLC. CAS No. 84454-35-3. Molecular formula: C16H16N2O2. Mole weight: 268.31. | |
| β-Endorphin (1-26) (human) trifluoroacetate salt | β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is an opioid receptor agonist that inhibits potassium-induced norepinephrine (NE) release in rat cortical slices (IC50 = 2.5 nM). Grades: ≥95%. Molecular formula: C130H208N32O38S·xCF3COOH. Mole weight: 2859.3. | |
| β-Endorphin (1-27) (human) trifluoroacetate salt | β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It is an antagonist of β-endorphin analgesia. Grades: ≥95%. Molecular formula: C139H217N33O40S·xCF3COOH. Mole weight: 3022.47. | |
| β-Endorphin (human) trifluoroacetate acid | β-Endorphin is an endogenous 31-amino acid neuropeptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 3.73, 5.02, and 32.7 nM, respectively, in COS-1 cells expressing rat receptors). Synonyms: β-Lipotropin (61-91). Grades: ≥95%. Molecular formula: C158H251N39O46S·xCF3COOH. Mole weight: 3464.98. | |
| β-Endorphin (rat) | β-Endorphin is an endogenous 31-amino acid neuropeptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 3.73, 5.02, and 32.7 nM, respectively, in COS-1 cells expressing rat receptors). Synonyms: H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Val-His-Lys-Lys-Gly-Gln-OH; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonyl-L-leucyl-L-phenylalanyl-L-lysyl-L-asparagyl-L-alanyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-asparagyl-L-valyl-L-histidyl-L-lysyl-L-lysyl-glycyl-L-glutamine. Grades: ≥95%. CAS No. 309246-19-3. Molecular formula: C157H254N42O44S. Mole weight: 3466.02. | |
| Betahistine dihydrochloride | Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM. Synonyms: N-methyl-2-pyridin-2-ylethanamine;dihydrochloride. Grades: > 98 %. CAS No. 5579-84-0. Molecular formula: C8H12N2 · 2HCl. Mole weight: 209.12. | |
| Betahistine mesylate | Betahistine is a structural analog of histamine that acts as a weak partial postsynaptic histamine H1 receptor agonist and presynaptic H3 receptor antagonist, with no effect on postsynaptic H2 receptors. Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms, e.g. those associated with Ménière's disease. Uses: Vasodilator agents. Synonyms: N-methyl-2-pyridineethanamine methanesulfonate (1:2); N-methyl-2-pyridineethanamine Dimethanesulfonate; Merislon. Grades: ≥98%. CAS No. 54856-23-4. Molecular formula: C8H12N2·2CH4O3S. Mole weight: 328.41. | |
| β-mangostin | Beta-mangostin, a natural product extracted from the fruits of Garcinia mangostana, can reduced the levels of TNF-α and IL-1β in peritoneal fluid. Synonyms: 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one beta-Mangostin 20931-37-7 CHEMBL261706 Q-100264 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one 1,6-DIHYDROXY-3,7-DIMETHOXY-2,8-BIS(3-METHYLBUT-2-EN-1-YL)-9H-XAN. Grades: >98%. CAS No. 20931-37-7. Molecular formula: C25H28O6. Mole weight: 424.49. | |
| Betamethasone hydrochloride | Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause water retention. It has shown the inflammatory response by the betamethasone-receptor complex modulated the activity of certain genes, altering the production and activity of proteins. It has also revealed to inhibit keratinocyte proliferation. It has anti-inflammatory and immunosuppressive properties. Uses: Betamethasone hydrochloride inhibits keratinocyte proliferation. it has anti-inflammatory and immunosuppressive properties. Grades: >98 %. CAS No. 956901-32-9. Molecular formula: C22H30ClFO5. Mole weight: 428.92. | |
| Betaxolol HCl | Cas No. 63659-19-8. | |
| BET-BAY 002 | BET-BAY 002 is a potent BET inhibitor with strong in vitro and in vivo activities in AML and MM models, and with excellent pharmacokinetic properties. Synonyms: 2-[[(4R)-6-(4-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-4-yl]methyl]-5-methyl-1,3,4-oxadiazoleBET-BAY 002; BET BAY 002; BETBAY 002; BETBAY002SCHEMBL16963184B48211588521-78-1. CAS No. 1588521-78-1. Molecular formula: C22H18ClN5O. Mole weight: 403.86. | |
| BET bromodomain inhibitor | A BET bromodomain inhibitor that can be used for the treatment of hematologic malignancies. It binds BET proteins to suppress the interaction between these proteins, propeins and acetylated chromatin, as well as transcription factors. The BET bromodomain inhibitor modulates the expression of oncogenes. Uses: The treatment of hematologic malignancies. Synonyms: MDK3597; MDK-3597; MDK 3597; BET bromodomain inhibitor. 2-[8-Chloro-6-(4-chloro-phenyl)-1-methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetamide. Grades: ≥98%. CAS No. 1505453-59-7. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.259. | |
| Bethanechol | Bethanechol, a synthetic ester structurally and pharmacologically related to acetylcholine, is a selective muscarinic receptor stimulant used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the abs. Uses: A selective muscarinic receptor stimulant, used to treat cerebral palsy. Synonyms: 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-; Carbamyl-β-methylcholine; 2-carbamoyloxypropyl(trimethyl)azanium. Grades: 95%. CAS No. 674-38-4. Molecular formula: C7H17N2O2. Mole weight: 161.22. | |
| Bethanechol Chloride | A selective muscarinic receptor stimulant, used to treat cerebral palsy. Uses: Parasympathomimetics. Synonyms: Bethanechol chloride; 590-63-6; Urecholine Myocholine Duvoid. Grades: 98%. CAS No. 590-63-6. Molecular formula: C7H17ClN2O2. Mole weight: 196.67. | |
| BET-IN-1 | BET-IN-1, an oxazole derivative, can be used as a bromodomain inhibitor. Synonyms: 4-[8-methoxy-1-[(2R)-1-methoxypropan-2-yl]-2-(oxan-4-yl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazoleBET-IN-1; BET IN 1SCHEMBL14698278CS-5464; HY-19760; CS 5464; HY 19760; CS5464; HY19760. CAS No. 1422554-34-4. Molecular formula: C25H30N4O4. Mole weight: 450.53. | |
| BETP | BETP is a positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor, displaying no effect on GLP-2, GIP, PTH or glucagon receptors. BETP promotes oxyntomodulin binding to GLP-1 receptor. It potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Synonyms: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine. Grades: ≥98% by HPLC. CAS No. 1371569-69-5. Molecular formula: C20H17F3N2O2S. Mole weight: 406.42. | |
| Bevenopran | Bevenopran is a peripherally selective μ- and δ-opioid receptor antagonist. It is used for the treatment of chronic opioid-induced constipation. It was developed by Cubist Pharmaceuticals and was in clinical phase 3 trial, but now it is terminated. Uses: Bevenopran is used for the treatment of chronic opioid-induced constipation. Synonyms: 5- (2-Methoxy-4- ( ( (2- (tetrahydro-2H-pyran-4-yl) ethyl) amino) methyl) phenoxy) pyrazine-2-carboxamide; CB-5945, CB5945, CB 5945, ADL-5945, ADL5945, ADL 5945, MK2402, MK 2402, MK-2402,OpRA III; Bevenopran. Grades: 98%. CAS No. 676500-67-7. Molecular formula: C20H26N4O4. Mole weight: 386.45. | |
| BEZ235 Tosylate | BEZ235 tosylate is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Synonyms: NVP-BEZ235; BEZ 235 Tosylate; BEZ-235 Tosylate. Grades: >98%. CAS No. 1028385-32-1. Molecular formula: C37H31N5O4S. Mole weight: 641.74. | |
| BFH772 | BFH772, a structure analogue of BAW2881, was highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM, however, lost 500-fold potency on FLK-1, FLT-1, and FLT-4. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM. Synonyms: 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide; BFH-772; BFH 772; BFH772; 1-Naphthalenecarboxamide, 6-((6-(hydroxymethyl)-4-pyrimidinyl)oxy)-N-(3-(trifluoromethyl)phenyl)-. CAS No. 890128-81-1. Molecular formula: C23H16F3N3O3. Mole weight: 439.4. | |
| BG45 | BG45 is a class I HDAC inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively. Synonyms: BG45; BG-45; BG 45. Grades: 98%. CAS No. 926259-99-6. Molecular formula: C11H10N4O. Mole weight: 214.22. | |
| BGB-283 | BGB-283 is a selective Epidermal growth factor receptor and Proto oncogene protein b raf inhibitor under the development of BeiGene. BGB-283 shows antitumor activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 can inhibit B-RAFV600E-activated ERK phosphorylation and cell proliferation. In vivo, BGB-283 can lead to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell-line derived and primary human colorectal tumor xenografts bearing B-RAFV600E mutation. Phase I clinical trials for the treatment of solid tumours are on-going. Uses: Solid tumours. Synonyms: UNII-8762XZS5ZF; 8762XZS5ZF; BGB-283; BGB 283; BGB283; Beigene-283; Beigene283; Beigene 283; Lifirafenib; Compound 2.2b; Beigene-283; GTPL8958;5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one. Grades: 98%. CAS No. 1446090-77-2. Molecular formula: C25H17F3N4O3. Mole weight: 478.31. | |
| BGB-3111 | BGB-3111 is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability, achieving higher exposure and more complete target inhibition in the tissues than ibrutinib. Uses: Antineoplastic agents. Synonyms: 2-(4-phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide; SCHEMBL16208602; BDBM249900; BGB-3111; BGB 3111; BGB3111. CAS No. 1633350-06-7. Molecular formula: C27H29N5O3. Mole weight: 471.55. | |
| BGC 20-1531 hydrochloride | BGC 20-1531 hydrochloride is a potent and selective EP4 antagonist, which exhibits <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors. It has high affinity and selective with Ki of 3 nM for EP4 antagonist. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA. It also reverses PGE2-induced vasorelaxation with Kb of 15.85 nM in human middle cerebral and middle meningeal arterial rings. Synonyms: BGC20-1531 HCl; BGC20-1531 hydrochloride; BGC20-1531; BGC 20-1531; BGC-20-1531; BGC201531; BGC 201531; BGC-201531; PGN 1531; PGN-1531; PGN1531. Grades: ≥98%. CAS No. 1962928-26-2. Molecular formula: C26H24N2O6S·HCl. Mole weight: 529. | |
| BGC 20-761 | BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). BGC 20-761 was shown to reverse the amnesic effects of scopolamine and enhance memory consolidation in a rat model. Synonyms: BGC-20-761; BGC 20 761; 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine; N,N-Dimethyl-2-(5-methoxy-2-phenylindol-3-yl)ethylamine. Grades: ≥98% by HPLC. CAS No. 17375-63-2. Molecular formula: C19H22N2O. Mole weight: 294.39. | |
| BH3I-1 | BH3I-1 is a cell-permeable inhibitor that targets Bcl-2 family protein. It inhibits the binding of BH3 peptides to Bcl-xL and induces apoptosis of Bcl-xL expressing cells. Synonyms: BH3I-1; BH 3I-1; BH-3I-1; BH3I1; BH 3I1; BH-3I1. 2-[(5E)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-methylbutanoic acid. Grades: 99%. CAS No. 300817-68-9. Molecular formula: C15H14BrNO3S2. Mole weight: 400.31. | |
| BHPI | BHPI is an antagonist of estrogen receptor α (ERα), for it elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor. Uses: An antagonist of estrogen receptor α (erα). Synonyms: 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one. Grades: ≥95%. CAS No. 56632-39-4. Molecular formula: C21H17NO3. Mole weight: 331.4. | |
| B-HT 920 dihydrochloride | Talipexole is a D2 dopamine receptor agonist, displaying anti-Parkinsonian activity. Uses: A dopamine agonist, also an α2-adrenergic agonist. Synonyms: Talipexole; B-HT 920, B-HT-920, B-HT920, Talipexole HCl, Talipexole dihydrochloride, Domnin6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride;5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride. Grades: ≥98%. CAS No. 36085-73-1. Molecular formula: C10H15N3S 2HCl. Mole weight: 282.23. | |
| B-HT 933 dihydrochloride | B-HT 933 dihydrochloride is a selective α2-adrenoceptor agonist displaying 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor. B-HT 933 decreases blood pressure and cardiac output in cats, and exhibits antinociceptive activity in mice. Uses: Adrenergic alpha-agonists. Synonyms: B-HT 933 dihydrochloride; B-HT933 dihydrochloride; B-HT-933 dihydrochloride; Azepexole hydrochloride; Azepexole dihydrochloride; 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 36067-72-8. Molecular formula: C9H15N3O.2HCl. Mole weight: 254.16. | |
| B-HT 958 dihydrochloride | B-HT 958 dihydrochloride is a dopamine D2 receptor agonist and an α2-adrenoceptor partial agonist. Synonyms: B-HT 958 dihydrochloride; B-HT958 dihydrochloride; B-HT-958 dihydrochloride; 4H-Thiazolo(4,5-d)azepin-2-amine, 5,6,7,8-tetrahydro-6-((4-chlorophenyl)methyl)-, dihydrochloride; 2-Amino-6-(4-chlorobenzyl)-4,5,7,8-tetrahydro-6H-thiazolo(5,4-d)azepine dihydrochloride; 5,6,7,8-Tetrahydro-6-((4-chlorophenyl)methyl)-4H-thiazolo(4,5-d)azepin-2-amine dihydrochloride. Grades: 99%. CAS No. 36085-44-6. Molecular formula: C14H16ClN3S.2HCl. Mole weight: 366.74. | |
| BI-167107 | BI-167107 is a β-arrestin-biased D2R agonist that binds to β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM. Synonyms: BI 167107; BI167107. Grades: 98%. CAS No. 1202235-68-4. Molecular formula: C21H26N2O4. Mole weight: 370.4. | |
| BI 224436 | BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of>90 μM. Synonyms: BI-224436; BI 224436; BI224436. Grades: >98%. CAS No. 1155419-89-8. Molecular formula: C27H26N2O4. Mole weight: 442.51. | |
| BI-2536 | BI-2563 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. Synonyms: BI2536; BI 2536. Grades: 0.98. CAS No. 755038-02-9. Molecular formula: C28H39N7O3. Mole weight: 521.65. | |
| BI-3802 | BI-3802 is a highly potent BCL6 degrader that inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. It induces BCL6 polymerization and degradation via E3 ligase SIAH1, showing antitumor activity. Grades: ≥98% by HPLC. CAS No. 2166387-65-9. Molecular formula: C24H29ClN6O3. Mole weight: 484.98. | |
| BI605906 | BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inhibits TNFα-dependent IκB degradation and expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. It not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation. Uses: Bi605906 not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in ikkβ that trigger its activation. Synonyms: BI605906; BI-605906; BI 605906;3-AMino-4-(1,1-difluoropropyl)-6-(4-Methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxaMide. Grades: >98 %. CAS No. 960293-88-3. Molecular formula: C17H22F2N4O3S2. Mole weight: 432.51. | |
| BI 78D3 | BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) with > 100 fold selectivity over p38α and no effect on mTOR and PI-3K. BI 78D3 inhibits JNK interacting protein 1 (JIP1) binding to JNK (IC50 = 500 nM) and prevents JNK substrate phosphorylation. It blocks JNK-dependent Con A-induced liver damage and also restores insulin sensitivity in a mouse model of type II diabetes. Synonyms: JNK Inhibitor X; BI-78D3; BI78D3; BI 78D3; 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one. Grades: ≥99% by HPLC. CAS No. 883065-90-5. Molecular formula: C13H9N5O5S2. Mole weight: 379.37. | |
| BI-882370 | BI-882370 is a highly potent, selective, orally active RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively. BI-882370 is a potent and selective RAF inhibitor uniquely binding to the DFG-out conformation, whereas marketed BRAF inhibitors occupy the DFG-in conformation. BI-882370 inhibits proliferation of human BRAF-mutant melanoma cells with 100× higher potency (1-10 nmol/L) than vemurafenib. BI-882370 may provide an improved therapeutic window, enabling more pronounced and longer-lasting pathway suppression and thus resulting in improved efficacy. Synonyms: BI882370; BI 882370. Grades: ≥95%. CAS No. 1392429-79-6. Molecular formula: C28H33F2N7O2S. Mole weight: 569.7. | |
| BI-9564 | BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 μM, respectively), with selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Synonyms: 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; BI-9564; BI 9564; BI9564. CAS No. 1883429-22-8. Molecular formula: C20H23N3O3. Mole weight: 353.42. | |
| BIA10-2474 | This active molecular is a reversible FAAH (fatty acid amide hydrolase) inhibitor that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (except the brain and spinal cord) under the development of Bial-Portela & Ca. SA. BIA 10-2474 can interact with the human endocannabinoid system and was inpplicated in the treatment of a range of different medical conditions including anxiety, Parkinson's disease, chronic pain of multiple sclerosis, cancer, hypertension and obesity. Clinical trial with BIA 10-2474 was on-going. However, severe adverse events occurred in January 2016 affecting 5 patients, including leading to the death of one. Uses: Neurological disorders; pain; psychiatric disorders. Synonyms: BIA 10-2474; BIA-10-2474; BIA10-2474; N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide;UNII-5AP1ZW859M; SCHEMBL427970; 5AP1ZW859M; GTPL9001; DOWVMJFBDGWVML-UHFFFAOYSA-N. Grades: 98%. CAS No. 1233855-46-3. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
| Biapenem | Biapenem is a carbapenem antibiotic with in vitro activity against anaerobes. Synonyms: Omegacin; Biapenern; L-627; L 627; L627. Grades: 98%. CAS No. 120410-24-4. Molecular formula: C15H18N4O4S. Mole weight: 350.39282. | |
| BIBF0775 | BIBF0775 is an inhibitor of transforming growth factor beta receptor I (TGFβRI) with an IC50 of 34 nM. Synonyms: (Z) -N-Ethyl-N-Methyl-2-Oxo-3- (Phenyl ( (4- (Piperidin-1-Ylmethyl) Phenyl) Amino) Methylene) Indoline-6-Carboxamide. Grades: ≥98% by HPLC. CAS No. 334951-90-5. Molecular formula: C31H34N4O2. Mole weight: 494.6. | |
| BIBS 39 | BIBS 39, a nonpeptide angiotensin II receptor antagonist, has been found to exhibit potential antihypertensive activity in rat. It has been already discontinued against hypertension. Uses: Bibs 3 is a nonpeptide angiotensin ii receptor antagonist that has been found to exhibit potential antihypertensive activity in rat. Synonyms: BIBS-39; BIBS39; BIBS 39.; CHEMBL130896; 2-[4-[[2-butyl-6- (cyclohexylcarbamoylamino) benzimidazol-1-yl]methyl]phenyl]benzoic acid; AC1L2ZGG. Grades: 98%. CAS No. 133085-33-3. Molecular formula: C32H36N4O3. Mole weight: 524.65. | |
| BIBU 1361 dihydrochloride | BIBU 1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with ~ 100-fold lower potency than ErbB2 (IC50 = 290 nM) and selectivity over a range of other related tyrosine kinases (IC50 > 10 μM). BIBU 1361 blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Synonyms: BIBU 1361 dihydrochloride; BIBU1361 dihydrochloride; BIBU-1361 dihydrochloride; N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride. Grades: ≥97% by HPLC. CAS No. 793726-84-8. Molecular formula: C22H27ClFN7.2HCl. Mole weight: 516.87. | |
| BIBX 1382 dihydrochloride | BIBX 1382 dihydrochloride is a potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with > 1000-fold lower potency than ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). BIBX 1382 inhibits Lassa, Ebola and Marburg viruses. Synonyms: BIBX 1382 dihydrochloride; BIBX1382 dihydrochloride; BIBX-1382 dihydrochloride; Falnidamol Dihydrochloride; N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride. Grades: ≥97% by HPLC. CAS No. 1216920-18-1. Molecular formula: C18H19ClFN7.2HCl. Mole weight: 460.77. | |
| (-)-Bicuculline methiodide | (-)-Bicuculline methiodide is the methiodide salt of (+)-bicuculline, which is a potent antagonist of GABAA receptors. Synonyms: [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide. Grades: ≥99% by HPLC. CAS No. 40709-69-1. Molecular formula: C21H20INO6. Mole weight: 509.3. | |
| (-)-Bicuculline methobromide | (-)-Bicuculline methobromide is the methobromide salt of (+)-bicuculline, which is a potent antagonist of GABAA receptors. Synonyms: [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide. Grades: ≥98% by HPLC. CAS No. 73604-30-5. Molecular formula: C21H20BrNO6. Mole weight: 462.3. | |
| (-)-Bicuculline methochloride | (-)-Bicuculline methochloride is the methochloride salt of (+)-bicuculline, which is a potent antagonist of GABAA receptors. Synonyms: [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride. Grades: ≥99% by HPLC. CAS No. 53552-05-9. Molecular formula: C21H20ClNO6. Mole weight: 417.85. | |
| Bicyclol | Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. Synonyms: Bicyclol; SY 801; SY-801; SY801. Grades: >98%. CAS No. 118159-48-1. Molecular formula: C19H18O9. Mole weight: 390.34. | |
| (±)-BI-D | Approximately 2.4-2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160-200 nM, in Psip1 and double-KO cells. Synonyms: (±)-BI-D; BI-D; BI D; BID. Grades: >98%. CAS No. 1416258-16-6. Molecular formula: C25H27NO4. Mole weight: 405.49. | |
| Bifemelane hydrochloride | Bifemelane hydrochloride is a MAO inhibitor displaying antidepressant activity. Bifemelane reverses catalepsy induced by tetrabenazine in mice and increases locomotor activity in MPTP-treated marmosets. Bifemelane has the potential to treat cerebral infarction and Alzheimer's disease for its neuroprotective and nootropic effects. Uses: Antidepressant. Synonyms: Celeport; Alnert; 4-(2-Benzylphenoxy)-N-methylbutylamine hydrochloride. Grades: ≥99% by HPLC. CAS No. 62232-46-6. Molecular formula: C18H23NO.HCl. Mole weight: 305.84. | |
| Bifeprunox mesylate | Bifeprunox mesylate is a dopamine D2 and 5-HT1A partial agonist developed as an atypical antipsychotic for the treatment of schizophrenia and other psychotic indications. Uses: Atypical antipsychotic. Synonyms: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-1,3-benzoxazol-2-one mesylate. Grades: 98%. CAS No. 350992-13-1. Molecular formula: C24H23N3O2.CH4O3S. Mole weight: 481.56. | |
| BIIB021 | Cas No. 848695-25-0. | |
| BIIB028 | Cas No. 911398-13-5. | |
| BIIE 0246 | BIIE 0246 is a potent, selective and non-peptide antagonist which binds to the neuropeptide Y Y2 receptor (IC50 = 15 nM) with > 650-fold selectivity over Y1, Y4 and Y5 receptors. Synonyms: (2S) -5- (diaminomethylideneamino) -N- [2- (3, 5-dioxo-1, 2-diphenyl-1, 2, 4-triazolidin-4-yl) ethyl] -2- [ [2- [1- [2-oxo-2- [4- (6-oxo-5, 11-dihydrobenzo [c] [1] benzazepin-11-yl) piperazin-1-yl] ethyl] cyclopentyl] acetyl] amino] pentanamide; BIIE-0246; BIIE 0246; BIIE-0246; CHEMBL540989; GTPL1547; CTK8E9439; BIIE0246. Grades: >98 %. CAS No. 246146-55-4. Molecular formula: C49H57N11O6. Mole weight: 896.05. | |
| BIM 187 | BIM 187 is a bombesin/GRP receptor agonist that reduces food intake following i.p. administration. Synonyms: BIM 187; BIM187; BIM-187. CAS No. 137734-88-4. Molecular formula: C53H76N14O10. Mole weight: 1069.27. | |
| Bimoclomol | Bimoclomol is a heat shock protein (HSP) coinducer that exhibits cytoprotective effects. It can be used in the treatment of cardiovascular diseases. Synonyms: (3Z)-N-(2-hydroxy-3-piperidin-1-ylpropoxy)pyridine-3-carboximidoyl chloride; bimoclomol; bimoclomol, maleate (1:1). CAS No. 130493-03-7. Molecular formula: C14H20ClN3O2. Mole weight: 297.78. | |
| Bimolane | Bimolane is a topoisomerase II inhibitor. It has been widely used as an anti-neoplastic agent and for the treatment of psoriasis in China. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II. Uses: Psoriasis. Synonyms: Bimolane;4,4'-Ethylenebis[1-(morpholinomethyl)-2,6-piperazinedione];AT-1727; AT1727; AT 1727; CCRIS 7574; CCRIS7574; CCRIS-7574; NSC 351358. Grades: 98%. CAS No. 74550-97-3. Molecular formula: C20H32N6O6. Mole weight: 452.51. | |
| BIMU 8 | BIMU 8 is a potent and selective 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Synonyms: BIMU 8; BIMU8; BIMU-8; 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride; N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 134296-40-5. Molecular formula: C19H26N4O2.HCl. Mole weight: 378.9. | |
| BINA | BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2) with no effect on glutamate-induced activation of other mGlu receptor subtypes. BINA exhibits antipsychotic and anxiolytic properties in mice. Synonyms: 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid; Biphenylindanone A; Biphenyl-indanone A. Grades: ≥98% by HPLC. CAS No. 866823-73-6. Molecular formula: C30H30O4. Mole weight: 454.56. | |
| Binucleine 2 | Binucleine 2 is an inhibitor of cytokinesis function of the ARK-2 pathway. It is also an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. Synonyms: Binucleine 2; 220088-42-6; N'-[2-(3-chloro-4-fluorophenyl)-4-cyanopyrazol-3-yl]-N,N-dimethylmethanimidamide; N'-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide; HMS546I06; Probes1_000319; Probes2_000073; CHEMBL1598812; DTXSID90430554; Binucleine 2, >=97% (HPLC); CCG-41865; MFCD00177827; AKOS040755467; NCGC00165742-01; J-014418; SR-01000631912-1; N'-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethylformimidamide. Grades: ≥98%. CAS No. 220088-42-6. Molecular formula: C13H11ClFN5. Mole weight: 291.7. | |
| Biperiden Hydrochloride | Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson's Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. Synonyms: Akineton hydrochloride; NSC 170950; NSC 84989; NSC170950; NSC84989; NSC-170950; NSC-84989. Grades: >98%. CAS No. 1235-82-1. Molecular formula: C21H30ClNO. Mole weight: 347.92. | |
| Biphenyl-4-sulfonyl chloride | Biphenyl-4-sulfonyl chloride is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Synonyms: 4-phenylbenzenesulfonyl chloride. Grades: ≥ 95 %. CAS No. 1623-93-4. Molecular formula: C12H9ClO2S. Mole weight: 252.72. | |
| Bis(5-Amidino-2-Benzimidazolyl)Metane Ketone Hydrate | Bis(5-Amidino-2-Benzimidazolyl)Metane Ketone Hydrate is an intriguing biomedical compound, showcasing its remarkable complexity in the research of diverse diseases. Endowed with formidable antiviral attributes, it aids in studying viral infections such as the pernicious HIV and hepatitis viruses. Synonyms: [amino-[2-[[6-[amino(azaniumylidene)methyl]-1H-benzimidazol-2-yl]-dihydroxymethyl]-3H-benzimidazol-5-yl]methylidene]azanium. Molecular formula: C17H18N8O2. Mole weight: 366.38. | |
| bis(7)-Tacrine | Acetylcholinesterase (AChE) is the primary cholinesterase in the body. It is an enzyme catalyzing the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), which has been proposed as a clinical treatment for Alzheimer's disease. Bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine. It is thought to have multiple mechanisms of action including inhibition of AChE, and inihbititon of the amyloid precursor protein/beta-amyloid cascade. It has been shown to inhibit the formation of Aβ1-42 oligomers and reduce the amount of pre-formed Aβ1-42 oligomers. Synonyms: 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine. Grades: ≥98%. CAS No. 224445-12-9. Molecular formula: C33H40N4·2HCl. Mole weight: 565.6. | |
| Bisantrene | Bisantrene is an anthracenyl bishydrazone used as a particular anticancer drug. Bisantrene can lead to inhibition of DNA replicantion and DNA-protein crosslinking via intercalating with and disrupting the configuration of DNA. Uses: Anticancer drug. Synonyms: 9,?10-Anthracenedicarboxal?dehyde; 9,?10-bis[(4,?5-dihydro-1H-imidazol-2-yl)?hydrazone]. CAS No. 78186-34-2. Molecular formula: C22H22N8. Mole weight: 398.471. | |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I hydrochloride (BMI) is a water soluble form of Bisindolylmaleimide I. It is a staurosporine inspired molecule, which has been shown to display equally potent inhibition. BIM I is a highly selective, cell-permeable, and reversible PKC inhibitor with Ki of 14 nM that is structurally similar to the poorly selective PKC inhibitor staurosporine. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It can inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Synonyms: BIM I; GF109203X; Gö 6850. Grades: ≥98%. CAS No. 176504-36-2. Molecular formula: C25H24N4O2·HCl. Mole weight: 449. | |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells) and an inhibitory effect on PDK1 (IC50 = 14 μM). Synonyms: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. Grades: ≥97% by HPLC. CAS No. 137592-45-1. Molecular formula: C27H26N4O2. Mole weight: 438.52. | |
| Bisindolylmaleimide III | Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C) with structural similarity to the nonspecific PKC inhibitor staurosporine. It inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1. Synonyms: BIM III. Grades: ≥98%. CAS No. 137592-43-9. Molecular formula: C23H20N4O2. Mole weight: 384.4. | |
| Bisindolylmaleimide V | Bisindolylmaleimide IV (BIM IV) is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 of 0.10-0.55 μM. It is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 μM. BIM IV also inhibits protein kinase A with IC50 of 2-11.8 μM. Bisindolylmaleimide V is used as a negative control for the PKC (protein kinase C)-inhibitory activity. Synonyms: BIM V; Ro 31-6045. Grades: ≥98%. CAS No. 113963-68-1. Molecular formula: C21H15N3O2. Mole weight: 341.3. | |
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