BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Bromoenol lactone | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. |  |
| Bromosporine | Bromosporine, a broad spectrum inhibitor for bromodomains which play a key role in many cellular processes, is a chemical probe for bromodomain functional assays so that it is very helpful in elucidating further biological roles of reader domains. IC50: B. Synonyms: ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate Bromosporine 1619994-69-2 ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate Bromorsporine GTPL. CAS No. 1619994-69-2. Molecular formula: C17H20N6O4S. Mole weight: 404.44. | |
| Bromperidol | Bromperidol, a derivative of butyrophenone, is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the D2 dopamine and 5-HT2A serotonin receptor. Uses: Bromperidol is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the d2 dopamine and 5-ht2a serotonin receptor. Synonyms: 4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone; 4-[4-(p-Bromophenyl)-4-hydroxypiperidino]-4'-fluoro-butyrophenone; Azurene; Impromen; R 11333; R11333; R-11333; Tesoprel. Grades: 98%. CAS No. 10457-90-6. Molecular formula: C21H23BrFNO2. Mole weight: 420.32. | |
| Brompheniramine hydrogen maleate | Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist. Grades: >98%. CAS No. 980-71-2. Molecular formula: C16H19BrN2·C4H4. Mole weight: 435.31. | |
| Broxyquinoline | Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes. Synonyms: Broxyquinoline; NSC 1810; NSC-1810; NSC1810; Dibromoxyquinoline; UCB 5055; UCB-5055; UCB5055; Paramibe; Brodiar. Grades: >98%. CAS No. 521-74-4. Molecular formula: C9H5Br2NO. Mole weight: 302.95. | |
| BRP-7 | BRP-7 is a 5-LO activating protein (FLAP) inhibitor. Synonyms: BRP 7; BRP7. CAS No. 612046-20-5. Molecular formula: C26H27ClN2. Mole weight: 403. | |
| Bryostatin 3 | Bryostatin 3 has been found to be a potent protein kinase C activator and could probably be useful in studies of emerging cancers. Synonyms: Bryostatin 3; 143370-84-7; (4S, 5S, 7E, 9R, 11Z, 13S, 15S, 17S, 19R, 21R, 25R, 27R, 27aS)-17-(Acetyloxy)-4, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester. Grades: ≥95% by HPLC. CAS No. 143370-84-7. Molecular formula: C46H64O17. Mole weight: 888.99. | |
| BS181 | BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50) of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inhibited CDK2 at concentrations lower than 1 micromol/L, with CDK2 being inhibited 35-fold less potently (IC(50) 880 nmol/L) than CDK7. In MCF-7 cells, BS-181 inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines, and showed antitumor effects in vivo. The drug was stable in vivo with a plasma elimination half-life in mice of 405 minutes after i.p. administration of 10 mg/kg. The same dose of drug inhibited the growth of MCF-7 human xenografts in nude mice. BS-181 therefore provides the first example of a potent and selective CDK7 inhibitor with potential as an anticancer agent. Synonyms: BS-181; BS181; BS 181. CAS No. 1092443-52-1. Molecular formula: C22H32N6. Mole weight: 380.53. | |
| BS 181 dihydrochloride | BS 181 dihydrochloride is a selective CDK7 inhibitor (IC50 = 21 nM) displaying >40-fold selectivity for CDK7 over others CDKs. BS 181 promotes cell cycle arrest and apoptosis in a range of cancer cells in MCF-7 cells and inhibits MCF-7 tumor xenograft growth in mice. Synonyms: BS 181 dihydrochloride; BS181 dihydrochloride; BS-181 dihydrochloride; N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride. Grades: ≥99% by HPLC. Molecular formula: C22H32N6.2HCl. Mole weight: 453.45. | |
| BSJ-03-123 | BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions; induces differential E3 ligase recruitment and ensuing degradation of CDK6, but not CDK4. Synonyms: BSJ 03-123; BSJ 03 123; BSJ-03 123; BSJ03123; N-[2- (2-{2-[2- (4-{6-[ (6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidin-2-yl) amino]-3-pyridinyl}-1-piperazinyl) ethoxy]ethoxy}ethoxy) ethyl]-2-{[2- (2, 6-dioxo-3-piperidinyl) -1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]oxy}acetamide; Acetamide, N- [2- [2- [2- [2- [4- [6- [ (6-acetyl-8-cyclopentyl-7, 8-dihydro-5-methyl-7-oxopyrido [2, 3-d] pyrimidin-2-yl) amino] -3-pyridinyl] -1-piperazinyl] ethoxy] ethoxy] ethoxy] ethyl] -2- [ [2- (2, 6-dioxo-3-piperidinyl) -2, 3-dihydro-1, 3-dioxo-1H-isoindol-4-yl] oxy] -. Grades: ≥95%. CAS No. 2361493-16-3. Molecular formula: C47H56N10O11. Mole weight: 937.01. | |
| BSJ-03-204 | BSJ-03-204 is a potent and selective PROTAC® Cdk4/6 Degrader, linked by Cereblon ligand and CDK ligand. Synonyms: N-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)butyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide; Acetamide, N-[4-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-; N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide; BSJ-03204; BSJ03204; BSJ 03 204. Grades: ≥98%. CAS No. 2349356-09-6. Molecular formula: C43H48N10O8. Mole weight: 832.90. | |
| BSJ-Bump | BSJ-Bump is the negative control for BSJ-03-123. It displays binding and no degradation of cyclin dependent kinases 6 (CDK6) in vitro. Synonyms: N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide. Grades: ≥98%. CAS No. 2409918-48-3. Molecular formula: C48H58N10O11. Mole weight: 951.05. | |
| Btk inhibitor 1 | Btk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: Btk inhibitor 1. Grades: >98%. CAS No. 1412418-47-3. Molecular formula: C22H22N6O. Mole weight: 386.45. | |
| BTK inhibitor 1 (Compound 27) | BTK inhibitor 1 is an inhibitor of BTK with IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with IC50 of 2 nM. Synonyms: DC20199; Compound 27. Grades: ≥98%. CAS No. 2230724-66-8. Molecular formula: C24H23FN8O2. Mole weight: 474.49. | |
| Btk inhibitor 1 R enantiomer | Btk inhibitor 1 R enantiomer is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: 3-(4-phenoxyphenyl)-1-[(3R)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine; (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-. Grades: ≥98% by HPLC. CAS No. 1022150-12-4. Molecular formula: C22H22N6O. Mole weight: 386.45. | |
| Btk inhibitor 1 R enantiomer hydrochloride | Btk inhibitor 1R enantiomer Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: Btk inhibitor 1 R enantiomer hydrochloride. Grades: >98%. CAS No. 1553977-42-6. Molecular formula: C22H23ClN6O. Mole weight: 422.91. | |
| BTK inhibitor 2 | Bruton's tyrosine kinase (BTK), also known as tyrosine-protein kinase BTK, is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development. Btk inhibitor 2 is a BTK inhibitor. Grades: ≥98%. CAS No. 1558036-85-3. Molecular formula: C24H25N5O3. Mole weight: 431.49. | |
| BTS | A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin's interaction with F-actin. Does not affect platelet myosin II. Synonyms: BTS; BnNHTs; N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine. Grades: >98%. CAS No. 1576-37-0. Molecular formula: C14H15NO2S. Mole weight: 261.34. | |
| BTT 3033 | BTT 3033 is a selective inhibitor of α2β1 integrin (EC50 = 130 nM for α2β1 binding to collagen I) that binds to the α2I domain. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow, and also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Synonyms: BTT-3033; BTT 3033; BTT3033; 1- (4-Fluorophenyl)-N-methyl-N-[4[[ (phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide. Grades: ≥98% by HPLC. CAS No. 1259028-99-3. Molecular formula: C23H20FN5O3S. Mole weight: 465.5. | |
| Bucindolol | Bucindolol is a third-generation, non-selective β-adrenergic receptor blocker that acts on both β1 and β2 receptors. Ki values are 1.61, 1.20 and 68.9 nM for β1-, β2- and α1-adrenoceptors respectively. Bucindolol is a high-affinity, competitive beta blocker used in the treatment of congestive heart failure and hypertension. It also displays vasodilatory and antihypertensive actions. Synonyms: Benzonitrile, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-; 2- [2-Hydroxy-3- [ [2- (1H-indol-3-yl) -1, 1-dimethylethyl] amino] propoxy] benzonitrile; DL-Bucindolol; MJ 13105-1; o- (2-Hydroxy-3- ( (2-indol-3-yl-1, 1-dimethylethyl) amino) propoxy) benzonitrile; 2-(3-((1-(1H-indol-3-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)benzonitrile. Grades: ≥98%. CAS No. 71119-11-4. Molecular formula: C22H25N3O2. Mole weight: 363.45. | |
| Bufarenogin | Pseudobufarenogin is a natural compound extracted from toad species with unknown details. Synonyms: ψ-Bufarenogin. Grades: >98%. CAS No. 17008-69-4. Molecular formula: C24H32O6. Mole weight: 416.51. | |
| Bufexamac | Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe because of allergic reactions. Synonyms: Benzeneacetamide, 4-butoxy-N-hydroxy-; 4-Butoxy-N-hydroxybenzeneacetamide; Acetohydroxamic acid, 2-(p-butoxyphenyl)-; 2-(4-Butoxyphenyl)acetohydroxamic acid; 2-(p-Butoxyphenyl)acetohydroxamic acid; 4-Butoxyphenylacethydroxamic acid; Anderm; Bufexamic acid; CP 1044J3; Droxarol; Droxaryl; Feximac; Flogocid; Flogocid N plastigel; Malipuran; Mofenar; Norfemac; p-Butoxyphenylacethydroxamic acid; p-Butoxyphenylacetohydroxamic acid; Parfenac; Parfenal; Trolab. Grades: >98%. CAS No. 2438-72-4. Molecular formula: C12H17NO3. Mole weight: 223.27. | |
| Bufuralol hydrochloride | Bufuralol (Ro-34787) is a β-adrenoceptor blocker with partial peripheral vasodilating activity and is potentially useful for the treatment of hypertension. It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1'-hydroxylation. Most beta blockers are aryloxypropanolamine-based, in this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor. Synonyms: Ro 3-4787. Grades: ≥95%. CAS No. 60398-91-6. Molecular formula: C16H23NO2·HCl. Mole weight: 297.8. | |
| Burosumab | Burosumab is a human monoclonal antibody targeting the phosphaturic hormone fibroblast growth factor 23 (FGF23). Burosumab is currently in a phase III clinical trial for the treatment of patients with X-linked hypophosphatemia. Uses: The potential treatment of x-linked hypophosphatemia. Synonyms: KRN-23; KRN 23; KRN23. CAS No. 1610833-03-8. | |
| Butaprost | Butaprost is a structural analog of PGE2 and a selective agonist for the EP2 receptor subtype. It binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor. Butaprost does not bind appreciably to any of the other murine EP receptors. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: (±)-15-deoxy-16S-hydroxy-17-cyclobutyl PGE1; 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1. Grades: ≥95%. CAS No. 433219-55-7. Molecular formula: C23H38O5. Mole weight: 394.6. | |
| Butenoyl PAF | Platelet-activating factor (PAF) is a lipid mediator that is well-known for its ability to cause platelet aggregation, inflammation, and allergic response at very low concentrations (approaching picomolar). Butenoyl PAF is a PAF receptor agonist, which is the product of the oxidative decomposition of 2-arachidonoyl phospholipids. It is 100-fold more abundant in oxidized LDL than PAF. Synonyms: Butenoyl PAF. Grades: ≥98%. CAS No. 474944-25-7. Molecular formula: C28H56NO7P. Mole weight: 549.7. | |
| BVT 2733 hydrochloride | BVT 2733 hydrochloride is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1. Synonyms: BVT 2733 hydrochloride; BVT2733 hydrochloride; BVT-2733 hydrochloride; 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride. Grades: 99%. CAS No. 376641-65-5. Molecular formula: C17H21ClN4O3S2.HCl. Mole weight: 465.42. | |
| BW 245C | BW 245C, a prostaglandin analogue, is a selective prostanoid DP-receptor (DP1) agonist used to treat stroke where the Ki for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM and has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation. Synonyms: 7-[(4S)-3-[(3R)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxoimidazolidin-4-yl]heptanoic acid; 245C77; 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin; BW 245C; BW 245C, (R*,S*)-(+-); BW-245C. CAS No. 72814-32-5. Molecular formula: C19H32N2O5. Mole weight: 368.47. | |
| BW 246C | The prostaglandin D2 (PGD2) receptors are the members of G protein-coupled receptors. PGD2 receptors include the following proteins prostaglandin D2 receptor 1 (DP1) and prostaglandin D2 receptor 2 (DP2). BW 246C is a DP receptor agonist. BW 246C is the less active C-8 diastereomer of the DP receptor agonist BW 245C. The activity of BW 245C is 70-fold greater than that of BW 246C. Synonyms: 8-epi BW 245C. Grades: ≥98%. CAS No. 65705-83-1. Molecular formula: C19H32N2O5. Mole weight: 368.5. | |
| BW 373U86 | BW 373U86 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 1.8, 15 and 34 nM for δ, μ and κ receptors, respectively). Synonyms: BW-373U86; SNC-86; BW 373U86; SNC 86; BW373U86; SNC86; 4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide. Grades: ≥99% by HPLC. CAS No. 155836-50-3. Molecular formula: C27H37N3O2. Mole weight: 435.61. | |
| BW 723C86 hydrochloride | BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist used for the treatment of certain CNS disorders, such as epilepsy, migraine and feeding disorders. Uses: The treatment of cns disorders as epilepsy, migraine and feeding disorders. Synonyms: BW723C86; BW-723-C-86; BW 723 C 86; BW-723C86; BW 723C86; α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride. Grades: ≥99% by HPLC. CAS No. 160521-72-2. Molecular formula: C16H18N2OS.HCl. Mole weight: 322.85. | |
| BW 755C | Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: BW755C; BW-755C; 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-; 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine; 3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline; 3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline; 3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline; Compound BW 755C. Grades: ≥95%. CAS No. 66000-40-6. Molecular formula: C10H10F3N3. Mole weight: 229.20. | |
| BW A868C | Prostaglandin D2 (PGD2) has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system. BW A868C is a novel, selective and potent competitive antagonist of PGD2. BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. However, it has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. Synonyms: BWA-868C; BWA868C. Grades: ≥98%. CAS No. 118675-50-6. Molecular formula: C25H37N3O5. Mole weight: 459.6. | |
| BW-B 70C | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
| BX341 | BX341, also known as bifluranol, is a new fluorinated bibenzyl anti-androgen and one of a series of bibenzyls designed to present some of the hormonal properties of diethylstilboestrol (DES) but with a lower potential for toxicity. Synonyms: BX341; BX 341; BX-341; 2-fluoro-4-[3-(3-fluoro-4-hydroxyphenyl)pentan-2-yl]phenol; bifluranol; erythro-2,3-bis(3-fluor-4-hydroxyphenyl)pentan. CAS No. 34633-34-6. Molecular formula: C17H18F2O2. Mole weight: 292.32. | |
| BX 471 | BX 471 is a selective CCR1 antagonist. Synonyms: (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea; BX471; BX 471; BX-471; ZK811752; ZK 811752; ZK-811752. CAS No. 217645-70-0. Molecular formula: C21H24ClFN4O3. Mole weight: 434.89. | |
| BX471 hydrochloride | BX471 hydrochloride is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Synonyms: BX-471 hydrochloride; BX 471 hydrochloride; (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea hydrochloride. CAS No. 288262-96-4. Molecular formula: C21H25Cl2FN4O3. Mole weight: 471.35. | |
| BX 513 hydrochloride | BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki = 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors, respectively), and also acts as a US28 agonist. It inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Synonyms: BX-513 hydrochloride; BX513 hydrochloride; 1-Piperidinepentanenitrile, 4-(4-chlorophenyl)-4-hydroxy-α,α-diphenyl-, hydrochloride (1:1); 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride; VUF 2274 hydrochloride; 5-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-pentanenitrile hydrochloride. Grades: ≥99% by HPLC. CAS No. 1216540-18-9. Molecular formula: C28H29ClN2O.HCl. Mole weight: 481.46. | |
| BXL 628 | BXL 628 is a vitamin D3 analogue that competes with vitamin D receptor (VDR) for inhibition of prostate cell growth and RhoA/Rho-kinase signaling, a calcium sensitizing pathway. BXL 628 exhibits anti-proliferative and anti-inflammatory properties in benign prostatic hyperplasia (BPH) treatment. Uses: Potential treatment of benign prostatic hyperplasia (bph). Synonyms: Elocalcitol; (1R,3Z,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(E,2S)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol. Grades: 99%. CAS No. 199798-84-0. Molecular formula: C29H43FO2. Mole weight: 442.65. | |
| BYK 191023 dihydrochloride | BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 = 86, 17000, 162000 nM for iNOS, nNOS and eNOS, respectively) acting in a NADPH- and time-dependent manner. BYK 191023 decreases the nitrite levels in rats, and reverses pathological hypotension in the rodent endotoxin model. Synonyms: BYK191023 Dihydrochloride; BYK-191023 Dihydrochloride; BYK 191023 Dihydrochloride; BYK191023 2HCl; BYK-191023 2HCl; BYK 191023 2HCl;; 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1216722-25-6. Molecular formula: C14H14N4O.2HCl. Mole weight: 327.21. | |
| BYK 204165 | BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 = 5.38 and 7.35 for PARP-2 and PARP-1, respectively). BYK 204165 is 100-fold more potent for PARP-1 than PARP-2. Synonyms: PARP Inhibitor XIV; BYK204165; BYK-204165; BYK 204165; RT-017290; RT017290; RT 017290. 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione. Grades: ≥99% by HPLC. CAS No. 1104546-89-5. Molecular formula: C15H12N2O2. Mole weight: 252.27. | |
| BYK 49187 | BYK 49187 is a non-selective PARP inhibitor (pIC50 = 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2, respectively). Synonyms: BYK 49187; BYK49187; BYK-49187; 4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one. Grades: ≥98% by HPLC. CAS No. 163120-31-8. Molecular formula: C19H21N5O. Mole weight: 335.4. | |
| C 021 dihydrochloride | C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively). Synonyms: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride. Grades: ≥99%. CAS No. 1784252-84-1. Molecular formula: C27H41N5O2·2HCl. Mole weight: 540.57. | |
| C086 | C086 inhibits Hsp90 and BCR-ABL, resulting in decreased proliferation of tumor cells, including imatinib-resistant cells. Synonyms: C086; C 086; C-086. Grades: >98%. CAS No. 1160107-44-7. Molecular formula: C29H28O8. Mole weight: 504.53. | |
| C-1311 dihydrochloride | C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 can delay progression of cells through the S phase which was followed by G2 arrest at the EC(99) dose as a mitosis inhibitor. Phase I clinical trials for treatment of solid tumours and a phase II clinical trials for the treatment of breast cancer were discontinued. Uses: Anticancer agents. Synonyms: Imidacrine; XLS-002; C-1311 dihydrochloride; XLS 002; C 1311 dihydrochloride; XLS002; C1311 dihydrochloride; Symadex; Imidazoacridinone; CHEMBL3545337;5-(2-(diethylamino)ethylamino)--8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one. Grades: 98%. CAS No. 138154-55-9. Molecular formula: C20H26Cl2N4O3. Mole weight: 441.35. | |
| C16 Ceramide-1-phosphate (d18:1/16:0) ammonium salt | C16 Ceramide-1-phosphate (C16 C1P) is one of the main forms of C1P found in cells. It is created by phosphorylation of by ceramide kinase. It activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells. Synonyms: C16 C1P; C16 Ceramide-1-phosphate; N-(hexadecanoyl)-sphing-4-enine-1-phosphate; CerP(d18:1/16:0). Grades: ≥98%. CAS No. 1246303-22-9. Molecular formula: C34H71N2O6P. Mole weight: 634.91. | |
| C-176 | C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grades: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09. | |
| C-178 | C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grades: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27. | |
| C2N 8E12 | | |
| C7280948 | C7280948 is a novel PRMT1 inhibitor ( IC50=12.75 μM). Uses: A novel prmt1 inhibitor. Synonyms: C7280948; C-7280948; C 7280948; 4-amino-N-(2-phenylethyl)benzenesulfonamide; 4-amino-N-phenethylbenzenesulfonamide. Grades: ≥95%. CAS No. 587850-67-7. Molecular formula: C14H16N2O2S. Mole weight: 276.35. | |
| CA 074 | CA 074 is a potent and selective inhibitor of cathepsin B (Ki = 2-5 nM). It reduces bone metastasis in a 4T1.2 breast cancer model. Uses: Cysteine proteinase inhibitors. Synonyms: CA-074; CA074; CA 074; N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline. Grades: ≥98% by HPLC. CAS No. 134448-10-5. Molecular formula: C18H29N3O6. Mole weight: 383.44. | |
| CA-074 methyl ester | CA-074 Me is a membrane-permeable inhibitor of irreversible cathepsin B derived from CA-074. CA-074 Me would be hydrolyzed by intracellular esterases to CA-074, the active compound. Synonyms: Ca-074Me; Ca 074Me; Ca074Me; Cathepsin B Inhibitor IV; MFCD03452890; (S)-methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylate; CA-074 Me. Grades: 99.04 %. CAS No. 147859-80-1. Molecular formula: C19H31N3O6. Mole weight: 397.47. | |
| Ca2+ Channel Agonist 1 | A Ca2+ Channel Agonist that selectively acting on N-type Ca2+ channel and also be found to restrain the cdk activity at some extent. IC50: 14.23 uM (EC50, Ca2+ channel) 3.34 uM (EC50, cdk2). Uses: A ca2+ channel agonist that selectively acting on n-type ca2+ channel and also be found to restrain the cdk activity at some extent. Synonyms: Ca2+ channel agonist 1; SCHEMBL17628623; CS-5169; CS 5169; CS5169. Grades: 98%. CAS No. 1402821-24-2. Molecular formula: C19H26N6O. Mole weight: 354.46. | |
| CAL-130 | CAL-130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3-kinase (PI3K)/Akt activation is common in T cell acute lymphoblastic leukemia (T-ALL). Although four distinct class I PI3K isoforms (α, β, γ, δ) could participate in T-ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors. CAL-130 may be useful for therapy for T-ALL. Synonyms: CAL130; CAL 130. Grades: >98%. CAS No. 1431697-74-3. Molecular formula: C23H22N8O. Mole weight: 426.47. | |
| CAL-130 Hydrochloride | In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors. Synonyms: CAL-130 Hydrochloride; CAL 130 Hydrochloride; CAL130 Hydrochloride;(S)-2-(1-((2-amino-9H-purin-6-yl)amino)ethyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride. Grades: >98%. CAS No. 1431697-78-7. Molecular formula: C23H23ClN8O. Mole weight: 462.93. | |
| CAL-130 Racemate | CAL-130 racemate is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kγ/δ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Synonyms: CAL-130 Racemate; CAL 130 Racemate; CAL130 Racemate. Grades: >98%. CAS No. 474012-90-3. Molecular formula: C23H22N8O. Mole weight: 426.47. | |
| Calcitetrol | Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups. It increases blood calcium levels ([Ca2+]) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium, thus reducing the loss of calcium in the urine. It also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts. Synonyms: 1α, 24, 25-Trihydroxy VD3. Grades: >98%. CAS No. 72203-93-1. Molecular formula: C27H44O4. Mole weight: 432.64. | |
| Calcium channel-modulator-1 | A calcium channel modulator that blocks aortic contraction (IC50= 0.8 μM). Synonyms: 3-O-methyl 5-O-[3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propyl] 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide. CAS No. 136941-70-3. Molecular formula: C26H24Cl2N2O7S. Mole weight: 579.45. | |
| Calcium Levofolinate | Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. Synonyms: Saponins. Grades: >98%. CAS No. 80433-71-2. Molecular formula: C20H21CaN7O7. Mole weight: 511.5. | |
| Calcium-Sensing Receptor Antagonists I | Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Synonyms: 2(1H)-Quinazolinone, 1-(1-methylethyl)-4-[4-(1-methylethyl)phenyl]-6-(2-propyn-1-yloxy)-. Grades: >98%. CAS No. 478963-79-0. Molecular formula: C23H24N2O2. Mole weight: 360.45. | |
| Calhex 231 hydrochloride | The hydrochloride salt form of Calhex 231, which has been found to be a new calcium sensing receptor ligand. Synonyms: Calhex 231 hydrochloride; Calhex231 hydrochloride; Calhex-231 hydrochloride; 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 652973-93-8. Molecular formula: C25H27ClN2O.HCl. Mole weight: 443.41. | |
| Calindol hydrochloride | The calcium sensing receptor (CaSR) has a long amino terminal tail typical of family 3 of GPCRs including the metabotropic glutamate receptors, the c-aminobutyric acid B receptor and certain pheromone and taste receptors. Calindol hydrochloride is a new calcimimetic compound acting as (CaSR). It is a positive allosteric modulator of the human Ca2+ receptor which activates an extracellular ligand-binding domain-deleted, Rhodopsin-like, seven-transmembrane structure in the absence of Ca2+. Calindol is used to study the properties and distribution of CaSR in different types of cells and tissues. Synonyms: Calindol. Grades: ≥98%. CAS No. 729610-18-8. Molecular formula: C21H20N2·HCl. Mole weight: 336.9. | |
| Calmidazolium chloride | Calmidazolium chloride has been found to be a calcium channel protein inhibitor as well as a calmodulin antagonist. Synonyms: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride. Grades: ≥98% by HPLC. CAS No. 57265-65-3. Molecular formula: C31H23Cl7N2O. Mole weight: 687.70. | |
| Calmodulin-Dependent Protein Kinase II (290-309) trifluoroacetate salt | Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 52 nM and CaMKII-dependent phosphodiesterase activity with IC50 of 1.1 nM. Calmodulin-dependent protein kinase II (290-309) has been used in the study of CaM binding, autophosphorylation, and dynamics. Grades: ≥95%. Molecular formula: C103H185N31O24S·xCF3COOH. Mole weight: 2273.83. | |
| CALP1 | CALP1 is a cell-permeable calmodulin (CaM) agonist binding to the EF-hand/Ca2+-binding site and activating phosphodiesterase. CALP1 also binds to cytoplasmic sites on other Ca2+ channels such as NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). It was shown to suppress VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo. Synonyms: Calcium-like peptide 1. CAS No. 145224-99-3. Molecular formula: C40H75N9O10. Mole weight: 842.09. | |
| Calpain Inhibitor I | MG-101, also known as Calpain Inhibitor I and ALLN, is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Activities of MG-101 includes: (1) reduce colon injury caused by dinitrobenzene sulphonic acid, (2) overcome acquired resistance to TRAIL, (3) protect against atractyloside-induced toxicity. (4). reduce colon injury caused by dinitrobenzene sulphonic acid. Synonyms: (S)-N-Acetyl-L-leucyl-N-(1-formylpentyl)-L-leucinamide; ALLN; ALLnL; CI-1 (peptide); Calp I; Calpain inhibitor I; MG 101; (S)-N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal; MG-101. Grades: 98 %. CAS No. 110044-82-1. Molecular formula: C20H37N3O4. Mole weight: 383.52. | |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Cambinol | Cambinol is a cell-permeable inhibitor of SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Synonyms: 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone; Cambinol; NSC 112546; SIRT1 Inhibitor II; SIRT2 Inhibitor VI; SIRT 1/2 inhibitor IV; NSC112546; NSC-112546; NSC 112546. CAS No. 14513-15-6. Molecular formula: C21H16N2O2S. Mole weight: 360.43. | |
| Camizestrant | Camizestrant is an orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Synonyms: N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine; Estrogen receptor antagonist 2; AZD-9833; AZD 9833; AZD9833; NSC-828717; N-[1-(3-Fluoropropyl)-3-azetidinyl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-3-pyridinamine. Grades: ≥98%. CAS No. 2222844-89-3. Molecular formula: C24H28F4N6. Mole weight: 476.51. | |
| CaMKII-IN-1 | CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. Synonyms: CaMKII-IN-1; CaMKII; CaMKII IN-1; CaMKII IN 1; CaMKII-IN 1. Grades: >98%. CAS No. 1208123-85-6. Molecular formula: C29H30ClN5O2S. Mole weight: 548.1. | |
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