BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Baricitinib phosphate | Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Baricitinib has been approved by FDA for the treatment of rheumatoid arthritis (RA). Synonyms: INCB 028050; LY 3009104; INCB028050; LY3009104; LY-3009104; INCB-028050. Grades: >98%. CAS No. 1187595-84-1. Molecular formula: C16H20N7O6PS. Mole weight: 469.41. |  |
| Barnetil | Barnetil acts as a selective D2 and D3 receptor antagonist, which has high affinity for these receptors of dissociation constants of 2.2 nM and 2.4 nM respectively. It is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. It has also been shown to have clinically relevant affinity for the GHB receptor. It was launched by Sanofi-Aventis in 1976. Synonyms: Benzamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-; N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide; (±)-Sultopride; Barnetil; LIN 1418. Grades: 98%. CAS No. 53583-79-2. Molecular formula: C17H26N2O4S. Mole weight: 354.46. | |
| Batimastat sodium salt | Batimastat sodium salt (BB-94) is a potent, broad spectrum matrix metalloprotease (MMPs) inhibitor with IC50s of 3/4/20/6/4 nM for MMP-1/2/3/7/9 respectively. Synonyms: BB-94 sodium salt; BB 94 sodium salt; BB94 sodium salt. Grades: >98%. CAS No. 130464-84-5. Molecular formula: C23H30N3NaO4S2. Mole weight: 499.62. | |
| Bavdegalutamide | It is an orally active, specific androgen receptor (AR) PROTAC degrader, and is also an antineoplastic agent. It promotes ubiquitination and degradation of AR and can be used for the research of prostate cancer. Synonyms: 3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-; ARV-110; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide; N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide; ARV 110; ARV110; rac-N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-{4-[(4-{2-[(3R)-2,6-dioxopiperidin-3-yl]-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl}piperazin-1-yl)methyl]piperidin-1-yl}pyridazine-3-carboxamide. Grades: 98% by HPLC. CAS No. 2222112-77-6. Molecular formula: C41H43ClFN9O6. Mole weight: 812.29. | |
| Bavisant | Bavisant is a highly selective, orally active antagonist of the human H3 receptor. It is a novel mechanism of action, involving wakefulness and cognition. It has potential to be used as a treatment for ADHD. It was developed by Johnson & Johnson and has completed a phase II ADHD trial, but there has been no progress. Uses: Bavisant has potential to be used as a treatment for adhd. Synonyms: JNJ 31001074;JNJ-31001074; JNJ31001074; (4-Cyclopropylpiperazin-1-yl)-[4-(morpholin-4-ylmethyl)phenyl]methanone. Grades: >98%. CAS No. 929622-08-2. Molecular formula: C19H27N3O2. Mole weight: 329.44. | |
| Bavisant dihydrochloride | Bavisant dihydrochloride is the dihydrochloride form of Bavisant, which is a highly selective, orally active antagonist of the human H3 receptor. It may be used as a treatment for ADHD. It was developed by Johnson & Johnson and has completed a phase II ADHD trial, but there has been no progress. Uses: Bavisant dihydrochloride may be used as a treatment for adhd. Synonyms: JNJ 31001074 dihydrochloride; JNJ-31001074 dihydrochloride; JNJ31001074 dihydrochloride; (4-Cyclopropylpiperazin-1-yl)(4-(morpholin-4-ylmethyl)phenyl)methanone dihydrochloride;Methanone, (4-cyclopropyl-1-piperazinyl)(4-(4-morpholinylmethyl)phenyl)-, hydrochloride (1:2). Grades: >98 %. CAS No. 929622-09-3. Molecular formula: C19H29Cl2N3O2. Mole weight: 402.36. | |
| Bavisant dihydrochloride hydrate | The dihydrochloride hydrate salt form of Bavisant which is an orally bioavaliable and selective H3 receptor antagonist that could probably useful in the treatment of Attention-deficit hyperactivity disorder(ADHD). It is known to have been completed the Ph. Uses: The dihydrochloride hydrate salt form of bavisant which is a h3 receptor antagonist that could probably useful in the treatment of attention-deficit hyperactivity disorder(adhd). Synonyms: Bavisant dihydrochloride; JNJ-31001074-AAC; JNJ 31001074-AAC; JNJ31001074-AAC; UNII-C1H7H5X3RE; BAVISANT DIHYDROCHLORIDE; JNJ-31001074-AAC; 1103522-80-0; Bavisant dihydrochloride (USAN); Bavisant dihydrochloride [USAN]. Grades: 98%. CAS No. 1103522-80-0. Molecular formula: C19H31Cl2N3O3. Mole weight: 420.37. | |
| BAW2881 | BAW 2881 is a VEGFR (vascular endothelial growth factor receptor) inhibitor (IC50 = 0.82, 0.037, and 0.42 μM for VEGFR1, 2, and 3, respectively).It can inhibit proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. Synonyms: BAW2881; BAW-2881; BAW 2881; NVP-BAW2881; NVP-BAW-2881; NVP-BAW 2881. 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide. Grades: 98%. CAS No. 861875-60-7. Molecular formula: C22H15F3N4O2. Mole weight: 424.38. | |
| Bax channel blocker | A direct allosteric inhibitor of BAX. Synonyms: BAI1. Grades: >98 %. CAS No. 335165-68-9. Molecular formula: C19H21Br2N3O. Mole weight: 467.20. | |
| BAY-1143572 | BAY 1143572 is a highly selective, potent and orally available inhibitor ofPTEFb/CDK9 and shows convincing anti-tumor activity in multiple xenograft models by the induction of apoptosis. Synonyms: 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine; BAY1143572; BAY 1143572; BAY-1143572. Atuveciclib. CAS No. 1414943-88-6. Molecular formula: C18H18FN5O2S. Mole weight: 387.43. | |
| BAY 11-7082 | BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. Synonyms: BAY 11-7821; BAY 11-7082; BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-117082. Grades: >98%. CAS No. 19542-67-7. Molecular formula: C10H9NO2S. Mole weight: 207.25. | |
| BAY-1217389 | BAY-1217389, an imidazopyridazin derivative, has been found to be a TTK protein inhibitor that could probably be effective as an antineoplastic agent and also be a potentialcell death stimulant. It is still under Phase I trail for solid tumor. Synonyms: BAY1217389; BAY-1217389; BAY 1217389; N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide. Grades: 98%. CAS No. 1554458-53-5. Molecular formula: C27H24F5N5O3. Mole weight: 561.51. | |
| BAY-1251152 | BAY-1251152 is a potent and selective CDK9 inhibitor with anti-tumor activity. Synonyms: BAY 1251152; BAY1251152; (+)-BAY-1251152. Grades: ≥98% by HPLC. CAS No. 1610358-56-9. Molecular formula: C19H18F2N4O2S. Mole weight: 404.4. | |
| BAY 1436032 | BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grades: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. | |
| BAY-27-9955 | BAY-27-9955 is a specific glucagon receptor antagonist. Synonyms: 1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol; BAY-27-9955; BAY-27-9955; BAY-27-9955; BAY-279955; BAY-279955; BAY-279955; (+)-3,5-diisopropyl-2-(1-hydroxyethyl)-6-propyl-4'-fluoro-1,1'-biphenyl. Grades: >98%. CAS No. 202855-56-9. Molecular formula: C23H31FO. Mole weight: 342.49. | |
| Bay 36-7620 | BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Synonyms: (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one; BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B. Grades: >98 %. CAS No. 232605-26-4. Molecular formula: C19H18O2. Mole weight: 278.349. | |
| Bay 41-4109 less active enantiomer | Bay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation and replication. Synonyms: methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY 41-4109; methyl-(R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-pyrimidine-5-carboxylate. Grades: ≥98% (HPLC). CAS No. 476617-51-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY41-4109 racemic | BAY41-4109 racemic, a mixture of R-isomer of BAY41-4109 and S-isomer of BAY41-4109, is an antiviral compound that inhibits HBV replication by destabilizing capsid assembly, with an IC50 of 53 nM. Synonyms: Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. Grades: ≥98.0%. CAS No. 298708-79-9. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY-545 | BAY-545 is a potent and selective A2B adenosine receptor antagonist with IC50 of 59 nM. Synonyms: GTPL11224; EX-A2960; BAY 545; BAY545. Grades: 98%. CAS No. 1699717-32-2. Molecular formula: C18H22F3N3O4S. Mole weight: 433.4. | |
| Bay 55-9837 | Bay 55-9837 is a selective VPAC2 receptor agonist (EC50 = 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50=60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively in a competition binding assay). It promotes glucose-dependent insulin secretion in isolated human pancreatic islets and inhibits HIV-1 viral replication. CAS No. 463930-25-8. Molecular formula: C167H270N52O46. Mole weight: 3742.29. | |
| BAY 59-3074 | Bay 59-3074 is a novel, selective CB1/CB2 receptor partial agonist(Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). Uses: Novel cb1/cb2 receptor partial agonist. Synonyms: BAY-59-3074; BAY 59-3074; BAY59-30743-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester. Grades: ≥98%. CAS No. 406205-74-1. Molecular formula: C18H13F6NO4S. Mole weight: 453.358. | |
| BAY-598 | BAY-598 is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 values of 27 nM and 58 nM for biochemical and cellular activity, respectively. BAY 598 exhibits 100-fold selectivity for SMYD2 over other histone methyltransferases and non-epigenetic enzymes. Synonyms: (S, E) -N- (1- (N'-cyano-N- (3- (difluoromethoxy) phenyl) carbamimidoyl) -3- (3, 4-dichlorophenyl) -4, 5-dihydro-1H-pyrazol-4-yl) -N-ethyl-2-hydroxyacetamide; BAY-598; BAY 598; BAY598. CAS No. 1906919-67-2. Molecular formula: C22H20Cl2F2N6O3. Mole weight: 525.33. | |
| BAY-598 R-isomer | BAY-598 R-isomer is the R-isomer of BAY589 which is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 values of 27 nM and 58 nM for biochemical and cellular activity, respectively. BAY 598 exhibits 100-fold selectivity for SMYD2 over other histone methyltransferases and non-epigenetic enzymes. Synonyms: (R, E) -N- (1- (N'-cyano-N- (3- (difluoromethoxy) phenyl) carbamimidoyl) -3- (3, 4-dichlorophenyl) -4, 5-dihydro-1H-pyrazol-4-yl) -N-ethyl-2-hydroxyacetamide; BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer. CAS No. 1906920-28-2. Molecular formula: C22H20Cl2F2N6O3. Mole weight: 525.33. | |
| BAY 60-6583 | BAY 60-6583 is a potent and selective adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor) displaying selectivity for A2B over A1, A2A and A3 receptors. BAY 60-6583 decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM) and attenuates infarct size in a mouse model of myocardial ischemia, suggesting that it may be beneficial for the treatment of disorders in the coronary arteries, atherosclerosis and ischemia-reperfusion injury. Synonyms: BAY 60-6583; BAY-60-6583; BAY60-6583. 2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; BR 4887. Grades: ≥98% by HPLC. CAS No. 910487-58-0. Molecular formula: C19H17N5O2S. Mole weight: 379.44. | |
| Bay 60-7550 | Bay 60-7550 is a potent PDE2 inhibitor. It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A. Synonyms: BAY60-7550; BAY 60-7550; BAY-60-7550; BAY-607550; BAY 607550; BAY607550. Grades: >98%. CAS No. 439083-90-6. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| BAY 61-3606 | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Synonyms: BAY 61-3606; BAY 613606; BAY 61 3606; BAY-61-3606; BAY613606; BAY61 3606. Grades: >98%. CAS No. 732983-37-8. Molecular formula: C20H18N6O3. Mole weight: 390.4. | |
| BAY 61-3606 dihydrochloride | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Synonyms: BAY 61-3606 dihydrochloride; BAY-61-3606 dihydrochloride; BAY61-3606 dihydrochloride. Grades: >98%. CAS No. 648903-57-5. Molecular formula: C20H18N6O3.2HCl. Mole weight: 463.32. | |
| Bay 65-1942 free base | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Synonyms: BAY 65-1942; BAY-65-1942; BAY65-1942; BAY 651942; BAY-651942; BAY651942. BAY65-1942 free base. Grades: >98%. CAS No. 600734-02-9. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
| Bay 65-1942 hydrochloride | Bay 65-1942 hydrochloride is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Synonyms: KINK-1; KINK 1; KINK1; Bay65-1942 Hydrochloride; Bay651942 Hydrochloride; Bay65-1942 HCl; Bay651942 HCl. Grades: >98%. CAS No. 600734-06-3. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. | |
| Bay 65-1942 R form | Bay 65-1942 R form is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Synonyms: Bay 65-1942. Grades: >98%. CAS No. 758683-21-5. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
| BAY 73-6691 | BAY 73-6691 is a phosphodiesterase inhibitor selective for the PDE9A subtype under the development of Bayer. It selectively inhibits human PDE9 with IC50 value of 55 nM in vitro.BAY 73-6691 was developed for the treatment of Alzheimer's disease, but pre-clinical research is at an early stage. Uses: Alzheimer's disease. Synonyms: BAY-73-6691; BAY736691; BAY73-6691; UNII-80ZTV3INTW; (R)-Bay-73-6691; 1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one. Grades: 98%. CAS No. 794568-92-6. Molecular formula: C15H12ClF3N4O. Mole weight: 356.73. | |
| BAY-754 | BAY-754 is an ALK-1 inhibitor used as an anti-angiogenesis agent. It inhibited the eye vascular leakage in dose manner in mouse model. Uses: The treatment of eye disorders. Synonyms: BAY-754; BAY 754; BAY-54. | |
| BAY-8002 | BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM), which inhibits cellular lactate uptake in DLD-1 cells with IC50 of 85 nM. BAY-8002 significantly increases intratumor lactate levels and transiently modulated pyruvate levels. Synonyms: BAY 8002BAY-8002; BAY 8002; BAY8002; 2-(2-chloro-5-(phenylsulfonyl)benzamido)benzoic acid. Grades: ≥98%. CAS No. 724440-27-1. Molecular formula: C20H14ClNO5S. Mole weight: 415.85. | |
| BAY8040 | This active molecular is a Selective Human Neutrophil Elastase Inhibitor and combines excellent potency and selectivity with a promising pharmacokinetic profile. In animal models for pulmonary arterial hypertension, BAY8040 shows the efficancy of decreasing cardiac remodeling and amelioration of cardiac function in vivo. Uses: Cardiac remodeling and amelioration of cardiac function. Synonyms: BAY8040; BAY-8040; BAY 8040; (R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile. Grades: 98%. CAS No. 1194453-23-0. Molecular formula: C21H16F3N5O2. Mole weight: 427.39. | |
| BAY 85-8501 | This active molecular is a highly selective neutrophil elastase inhibitor.IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studies for the treatment of pulmonary diseases. In Feb 2013, Phase-II clinical trials in Bronchiectasis in Spain were on going. In Mar 2013, Phase-II clinical trials in Bronchiectasis in France, Germany and Italy were on going. In Jun 2014, Bayer completed a phase IIa trial in Bronchiectasis in United Kingdom, Spain, France, Germany and Italy. Uses: The treatment of pulmonary diseases. Synonyms: BAY 85-8501; BAY85-8501; BAY-85-8501; BAY 858501; BAY858501; BAY-858501. (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1161921-82-9. Molecular formula: C22H17F3N4O3S. Mole weight: 474.46. | |
| BAY 87-2243 | BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively. Synonyms: BAY 872243; BAY872243; BAY-872243; BAY 87-2243; BAY87-2243; BAY-87-2243. Grades: >98%. CAS No. 1227158-85-1. Molecular formula: C26H26F3N7O2. Mole weight: 525.53. | |
| BAY-X-1005 | BAY-X 1005 is a potent and selective FLAP (5-lipoxygenase-activating protein) inhibitor. BAY-X 1005 is also a selective inhibitor of leukotriene synthesis. BAY-X1005 inhibited LTB4 synthesis with IC50 values of 220 nM for isolated PMNL of human and inhibited LTC4 synthesis with IC50 value of 210 nM in mouse macrophages. Phase-III for Myocardial infarction in USA was suspended in 2006. Uses: Myocardial infarction. Synonyms: BAY-X-1005; BAY X 1005; BAYX1005; Veliflapon;DG-031; DG 031; DG031; (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid. Grades: >98 %. CAS No. 128253-31-6. Molecular formula: C23H23NO3. Mole weight: 361.43. | |
| BAY-Y 3118 | BAY-Y 3118 is a 4-quinolone with outstanding antimicrobial activity against Gramnegative and Gram-positive pathogens as well as anaerobic and intracellular bacteria and might be an important contribution to progress in anti-infective therapy. Synonyms: 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid; 1-cyclopropyl-7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride; Bay y 3118; Bay Y3118; Bay-Y3118. CAS No. 151213-16-0. Molecular formula: C20H21ClFN3O3. Mole weight: 405.85. | |
| BBT594 | BBT594, also called as NVP-BBT594, a dihydroindole compound, originally developed as an inhibitor of wild-type and T315I-mutant BCR-ABL1, and then subsequently was shown to inhibit JAK2 activity (IC50 = 8nM ~ 29nM in murine models). The Type II JAK2 inhibitor NVP-BBT594 also displayed potent inhibition of HCV activity (EC50 < 1.5 mM). BBT594 impairs GDNF-RET signaling, a promising therapeutic target to enhance the sensitivity to aromatase inhibitor (AI) treatment and revert AI resistance in ER+ breast cancer cells. It also impairs GDNF-dependent growth of MCF7-LTED cells. Synonyms: 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide; BBT-594; BBT-594; BBT-594; NVP-BBT594; NVP BBT594; NVP BBT-594GTPL7584; SCHEMBL12972358; 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide. CAS No. 882405-89-2. Molecular formula: C28H30F3N7O3. Mole weight: 569.59. | |
| BC 11-38 | BC 11-38 is a potent and selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). BC 11-38 increases cAMP and cortisol levels in H295R human adenocarcinoma cells. Synonyms: BC11-38; BC 11-38; BC-11-38. 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one; 3-phenyl-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one. Grades: ≥98% by HPLC. CAS No. 686770-80-9. Molecular formula: C15H16N2OS2. Mole weight: 304.43. | |
| BC2059 | BC2059 is a novel β-catenin antagonist and its treatment dose-dependently induced apoptosis of cultured and primary AML BPCs. BC2059 also significantly improved the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs, showing nuclear expression of β-catenin. Synonyms: BC2059; BC-2059; BC 2059; (9E,10E)-2,7-bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime. Grades: 98%. CAS No. 1227637-23-1. Molecular formula: C28H36N4O6S2. Mole weight: 588.74. | |
| BCI-121 | BCI-121, a SMYD3 inhibitor, induces a significant reduction in SMYD3 activity both in vitro and in CRC cells. Synonyms: 1-[2-(4-bromoanilino)-2-oxoethyl]piperidine-4-carboxamide; 1-(2-((4-bromophenyl)amino)-2-oxoethyl)piperidine-4-carboxamide; 1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide; BAS 04914128; AC1LGJJ6. CAS No. 432529-82-3. Molecular formula: C14H18BrN3O2. Mole weight: 340.22. | |
| BCTC | BCTC is a TRPA1 and TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively. Uses: Orally effective vanilloid receptor 1. Synonyms: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide. Grades: ≥98%. CAS No. 393514-24-4. Molecular formula: C20H25ClN4O. Mole weight: 372.89. | |
| BCX 1470 | In vitro BCX 1470 inhibits the esterolytic and hemolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM) which is the complement enzymes. BCX 1470 may used for the treatment of complement activation during cardiopulmonary bypass surgery. Synonyms: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate; 2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate; BCX 1470; BCX1470; BCX-1470. Grades: 95%. CAS No. 217099-43-9. Molecular formula: C14H10N2O2S2. Mole weight: 302.37. | |
| BCX 1470 methanesulfonate | BCX 1470 methanesulfonate is methanesulfonate salt form of BCX 1470. In vitro BCX 1470 inhibits the esterolytic and hemolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM) which is the complement enzymes. BCX 1470 may used for the treatment of c. Synonyms: BCX 1470 methanesulfonate; BCX-1470 methanesulfonate; BCX1470 methanesulfonate; (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate;methanesulfonic acidBCX 1470 (methanesulfonate)217099-44-0BCX 1470 (methanesulfonate) CHEMBL2203422C14H10N2O2S2. CH4O3S3166AH2- (Aminoiminomethyl) benzo[b]thiophen-6-yl ester 2-thiophenecarb. Grades: 95%. CAS No. 217099-44-0. Molecular formula: C14H10N2O2S2.CH4O3S. Mole weight: 398.47. | |
| BCX4430 freebase | BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes. Uses: Antiviral agents. Synonyms: BCX-4430 freebase; BCX 4430 freebase; BCX4430 freebase; Immucillin-A; Immucillin A. Grades: >98%. CAS No. 249503-25-1. Molecular formula: C11H15N5O3. Mole weight: 265.27. | |
| BCX 4430 hydrochloride | BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes. Synonyms: BCX-4430; BCX 4430; BCX4430; Immucillin-A hydrochloride; Immucillin A hydrochloride. Grades: >98%. CAS No. 222631-44-9. Molecular formula: C11H16ClN5O3. Mole weight: 301.73. | |
| BD 1008 dihydrobromide | BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimulant effects of cocaine, and can be used as the treatment of cocaine overdose and neuropathic pain after chemotherapy. Synonyms: BD1008 dihydrobromide; BD-1008 dihydrobromide; N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide; 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-, hydrobromide (1:2); 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-, dihydrobromide. Grades: ≥95%. CAS No. 138356-09-9. Molecular formula: C15H22Cl2N2.2HBr. Mole weight: 463.08. | |
| BD 1047 dihydrobromide | The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schizophrenia and neuropathic pain. Uses: The dihydrobromide salt form of bd-1047 is a selective σ1 receptor antagonist that has been found to have antipsychotic effect and could be probably used against schizophrenia and neuropathic pain. Synonyms: BD 1047 DIHYDROBROMIDE; BD-1047 (dihydrobromide); BD-1047 dihydrobromide; N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. Grades: 98%. CAS No. 138356-21-5. Molecular formula: C13H22Br2Cl2N2. Mole weight: 437.04. | |
| BD1063 dhydrochloride | Cas No. 206996-13-6. | |
| BDNF (human) | Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF Gene. BDNF is a member of the neurotrophin growth factor family, which binds and activates TrkB and p75 neurotrophin receptors. It can enhances the survival, growth and differentiation of neurons. BDNF has been shown to play a role in neuroplasticity, which allows nerve cells in the brain to compensate for injury. Synonyms: BDNF. Grades: ≥96%. CAS No. 218441-99-7. Mole weight: 26984. | |
| Beclabuvir | Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabuvir is a thumb site 1-NS5B polymerase ligand. Beclabuvir has been shown to equally inhibit de novo and primer dependent synthesis, 5-75 fold more potently than previously studied compounds, thus resulting the most effective thumb site 1 inhibitor of genotype 1 (GT-1) NS5B polymerase. Synonyms: (4bS, 5aR)-12-cyclohexyl-N-(N, N-dimethylsulfamoyl)-3-methoxy-5a-((1R, 5S)-3-methyl-3, 8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b, 5, 5a, 6-tetrahydrobenzo[3, 4]cyclopropa[5, 6]azepino[1, 2-a]indole-9-carboxamide hydrochloride; BMS791325; BMS-791325; BMS 791325. Grades: 99.87%. CAS No. 958002-33-0. Molecular formula: C36H45N5O5S. Mole weight: 659.84. | |
| Begacestat | Begacestat is a selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase. Begacestat inhibits Abeta production with low nanomolar potency in cellular and cell-free assays of γ-secretase function. In Sep 2010, Phase-I for Alzheimer's disease in USA was discontinued. Uses: Alzheimer's disease. Synonyms: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI-953; GSI953; GSI 953. Grades: 98%. CAS No. 769169-27-9. Molecular formula: C9H8ClF6NO3S2. Mole weight: 391.74. | |
| Belizatinib | Belizatinib is inhibitor of both anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases (TRK). Belizatinib can bind to and inhibit both ALK and TRK kinases and this inhibition can lead to the disruption of ALK- and TRK-mediated signaling and impede tumor cell growth in ALK/TRK-overexpressing tumor cells. Phase I/II clinical trials for Lymphoma, Non-small cell lung cancer and Solid tumours is on-going. Uses: Lymphoma; non-small cell lung cancer; solid tumours. Synonyms: TSR011; TSR011; TSR 011; Belizatinib;4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide. Grades: 98%. CAS No. 1357920-84-3. Molecular formula: C33H44FN5O3. Mole weight: 577.75. | |
| Bemegride | Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. Synonyms: Bemegride; Antibarbi; Agipnon; Ahypnon; Eukraton; Malysol; Mikedimide; Zentraleptin. Grades: >98%. CAS No. 64-65-3. Molecular formula: C8H13NO2. Mole weight: 155.19. | |
| Bemnifosbuvir | Bemnifosbuvir is the precursor drug form of the antiviral nucleoside analogue AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 μM, respectively). Synonyms: propan-2-yl N-[(P5'S,2'R)-2-amino-2'-deoxy-2'-fluoro-N6,2'-dimethyl-OP-phenyl-5'-adenylyl]-L-alaninate; AT-511; N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-L-alanine, 1-methylethyl ester. Grades: 98%. CAS No. 1998705-64-8. Molecular formula: C24H33FN7O7P. Mole weight: 581.53. | |
| Bengamide B | Bengamide B is a potent inhibitor of methionine amino transferase (MetAPs 1 and -2), and it also acts as a NF-kB blocker. Bengamide B exhibits inhibitory activity for proliferation of HeLa and HCT116 cells. Uses: Antitumor and anti-inflammatory agent. Synonyms: (6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-D-gulo-Non-6-enonamide. Grades: ≥97% by HPLC. CAS No. 104947-69-5. Molecular formula: C32H58N2O8. Mole weight: 598.81. | |
| Benidipine | A triple L-, T-, and N-type calcium channel blocker. It is a long-lasting medication indicated for the treatment of cardiovascular diseases such as hypertension, renoparenchymal hypertension and angina pectoris. Synonyms: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-rel-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-(±)-; (±)-Benidipine; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-. Grades: ≥95%. CAS No. 105979-17-7. Molecular formula: C28H31N3O6. Mole weight: 505.57. | |
| Benzenesulfonamide | Benzenesulfonamide ia an inhibitor of carbonic anhydrases. Synonyms: Benzenesulfonyl amine; Benzenesulphonamide; M and B 7973; NSC 5341; NSC 85506; Phenylsulfonamide. Grades: ≥95%. CAS No. 98-10-2. Molecular formula: C6H7NO2S. Mole weight: 157.19. | |
| Benzisoxazole Hsp90 Inhibitor | Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines with IC50 of 0.28 μM, which promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases. Synonyms: BHI. Grades: ≥98%. CAS No. 1012788-65-6. Molecular formula: C19H20ClN3O4. Mole weight: 389.8. | |
| Benzonatate | Benzonatate is a reversible voltage-gated sodium channel blocker, which is also known as Tessalon and KM-65. Benzonatate's mechanism of action is thought to be anesthesia of vagal sensory nerve fibers that mediate cough. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. Synonyms: Benzoic acid, 4-(butylamino)-, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester; Benzoic acid, p-(butylamino)-, 2- [2- [2- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethyl ester; Benzoic acid, p-(butylamino)-, ester with 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-ol; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl 4-(butylamino)benzoate; Benzononantin; Benzononatine; Exangit; KM 65; Tesalon; Tessalin; Tessalon; Tessalon-Ciba; Ventussin; Ventussin-Loz. Grades: ≥98%. CAS No. 104-31-4. Molecular formula: C30H53NO11. Mole weight: 603.74. | |
| Benzoquinonium dibromide | Benzoquinonium dibromide is an AChR and ganglion inhibitor stimulating single channels but blocking open channels at nicotinic receptors. Synonyms: N, N'- [ (3, 6-Dioxo-1, 4-cyclohexadiene-1, 4-diyl) bis (imino-3, 1-propanediyl) ] bis [N, N-diethylbenzenemethanaminium] dibromide. CAS No. 311-09-1. Molecular formula: C34H50Br2N4O2. Mole weight: 706.6. | |
| Benzquinamide Hydrochloride | Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure and problely benzquinamide works through antagonism of muscarinic acetycholine receptors and histamine H1 receptors. Uses: Antipsychotic; antiemetic. Synonyms: Benzquinamide hydrochloride; P-2647 hydrochloride; P2647 hydrochloride; P 2647 hydrochloride; 2-(Acetyloxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizine-3-carboxamide Hydrochloride, CAS 63-12-7-free base,P-2647 hydrochloride; Benzquinamida. Grades: 95%. CAS No. 113-69-9. Molecular formula: C22H33ClN2O5. Mole weight: 440.96. | |
| Bephenium | Bephenium is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis. Synonyms: BEPHENIUM; 7181-73-9; Benzyldimethyl(2-phenoxyethyl)ammonium; benzyl-dimethyl-(2-phenoxyethyl)azanium; Ammonium, benzyldimethyl(2-phenoxyethyl)-; Benzenemethanaminium, N,N-dimethyl-N-(2-phenoxyethyl)-; PXO9B4983I; Bephenum; HSDB 3207; EINECS 230-546-7; BRN 4143098; UNII-PXO9B4983I; N,N-Dimethyl-N-(2-phenoxyethyl)-benzenemethanaminium; BEPHENIUM [HSDB]; bephenium-hydroxynaphthoate; Oprea1_022605; SCHEMBL44590; CHEMBL1788404; DTXSID3022661; CHEBI:135055; CS-3868; DB13462; HY-12639; SBI-0206911.P001; AB00514746; AB00514746_03; AB00514746_04; N,N-dimethyl-N-(phenylmethyl)-2-(phenyloxy)ethanaminium. Grades: >98%. CAS No. 7181-73-9. Molecular formula: C17H22NO+. Mole weight: 256.36. | |
| Bephenium hydroxynaphthoate | Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis, which belongs to B-type AChR activator. Synonyms: Alcopar; Bephenium embonate. Grades: >98%. CAS No. 3818-50-6. Molecular formula: C28H29NO4. Mole weight: 443.53. | |
| Bepotastine | Bepotastine is a 2nd generation antihistamine. It is currently marketed in the United States as an eye drop under the brand-name Bepreve, by ISTA Pharmaceuticals. Bepotastine is a histamine H1 receptor antagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus). The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve. Synonyms: TAU284; TAU-284; TAU 284; Talion; Bepreve. Grades: ≥98%. CAS No. 125602-71-3. Molecular formula: C21H25ClN2O3. Mole weight: 388.89. | |
| Bepridil hydrochloride | Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation. Synonyms: Angopril; Bepadin; Bepridil HCl. CAS No. 68099-86-5. Molecular formula: C24H34N2O.HCl. Mole weight: 403.007. | |
| Bepridil hydrochloride hydrate | Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation. Uses: Antihypertensive agents. Synonyms: Hydrogen Bepridil Hydrate Chloride; Bepridil Chloride Monohydrate. CAS No. 74764-40-2. Molecular formula: C24H34N2O.HCl.H2O. Mole weight: 421.022. | |
| Besonprodil | Besonprodil, a benzimidazolone bioisostere, is an NMDA antagonist that selective for the NR2B subunit. Synonyms: 6-[2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethylsulfinyl]-3H-1,3-benzoxazol-2-one; Besonprodil; CI-1041; CI 1041; CI104; 1253450-09-8; UNII-5K3N2D15WW; CHEMBL219631; Besonprodil (USAN); PD 196860; PD196860; PD-196860. Grades: >98%. CAS No. 253450-09-8. Molecular formula: C21H23FN2O3S. Mole weight: 402.48. | |
| Bestatin trifluoroacetate | Bestatin, also known as Ubenimex (INN), is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia. Bestatin can be administered, with low toxicity, to cultured cells, intact animals and humans. It has become a useful tool in elucidating the physiological role of some mammalian exopeptidases in the regulation of the immune system, in the growth of tumors and their invasion of surrounding tissues, and in the degradation of cellular proteins. Synonyms: Ubenimex trifluoroacetate. Grades: >98%. CAS No. 223763-80-2. Molecular formula: C18H25F3N2O6. Mole weight: 422.4. | |
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