BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ZM 39923 | ZM 39923 inhibits Janus kinase (IC50=10 nM). Synonyms: 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one273727-89-2beta-(Isopropylbenzylamino)-2'-propionaphthoneZM-39923; JAK3 inhibitor IV; ZM 39923; ZM39923;3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-oneNCGC00025. CAS No. 273727-89-2. Molecular formula: C23H25NO. Mole weight: 331.45. |  |
| ZM 39923 hydrochloride | ZM 39923 hydrochloride is a potent and selective inhibitor of Janus tyrosine kinase 3 (JAK3) (pIC50 = 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4, respectively). ZM 39923 breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to produce an active analog, ZM 449829. Synonyms: ZM 39923; ZM-39923; ZM39923 HCl; 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride; JAK3 Inhibitor IV. Grades: ≥99% by HPLC. CAS No. 58753-54-1. Molecular formula: C23H25NO.HCl. Mole weight: 367.92. | |
| ZM447439 | ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C. Synonyms: Code name: ZM447439; ZM-447439; ZM 447439. Grades: 0.98. CAS No. 331771-20-1. Molecular formula: C29H31N5O4. Mole weight: 513.59. | |
| ZM 449829 | ZM 449829 is a potent and selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site (pIC50 = 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4, respectively). ZM 449829 inhibits STAT-5 phosphorylation and T cell proliferation. Synonyms: ZM 449829; ZM449829; ZM-449829; 1-(2-Naphthalenyl)-2-propen-1-one; JAK3 inhibitor V. Grades: ≥98% by HPLC. CAS No. 4452-6-6. Molecular formula: C13H10O. Mole weight: 182.22. | |
| Zolantidine dimaleate | Zolantidine dimaleate is a potent brain penetrating histamine H2 receptor antagonist. Synonyms: N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine dimaleate; SKF 95282 dimaleate; SKF95282 dimaleate; SKF-95282 dimaleate. CAS No. 104076-39-3. Molecular formula: C22H27N3OS.2C4H4O4. Mole weight: 613.68. | |
| Zoledronic Acid Hydrate | Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget's disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. Synonyms: Zoledronate monohydrate; CGP 42446 monohydrate; ZOL 446 monohydrate; CGP42446 monohydrate; ZOL446 monohydrate; CGP-42446 monohydrate; ZOL-446 monohydrate; CGP42446A monohydrate. Grades: >98%. CAS No. 165800-06-6. Molecular formula: C5H12N2O8P2. Mole weight: 290.1. | |
| Zoleprodolol | Zoleprodolol, an oxadiazol derivative, has been found to be an adrenergic receptor antagonist. Synonyms: Zoleprodolol; Zoleprodolol [INN]; 1-(tert-butylamino)-3-[2-[(3-methoxy-1,2,4-oxadiazol-5-yl)methoxy]phenoxy]propan-2-ol; 1-(tert-butylamino)-3-{2-[(3-methoxy-1,2,4-oxadiazol-5-yl)methoxy]phenoxy}propan-2-ol; AC1L3230; MCULE-5529397605. Grades: 98%. CAS No. 158599-53-2. Molecular formula: C17H25N3O5. Mole weight: 351.40. | |
| Zomepirac Sodium | Zomepirac sodium salt is a prostaglandin synthetase inhibitor, was indicated for the management of mild to severe pain. Uses: An analgesic, anti-inflammatory drug. Synonyms: 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic Acid Sodium Salt; McN 2783-21-98; 2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid. Grades: ≥98%. CAS No. 64092-48-4. Molecular formula: C15H13ClNNaO3. Mole weight: 313.71. | |
| Zonisamide sodium salt | Zonisamide is the first agent of this chemical class to be developed as an antiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Uses: Sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive t-type calcium currents. heterocyclic methanesulfonide with anticonvulsant properties. the compound is under investigation for potent. Synonyms: 1,2-benzisoxazole-3-methanesulfonamide sodium-potassium salt;1,2-Benzisoxazole-3-methanesulfonamide sodium-potassium salt, Aleviatin sodium-potassium salt, Exceglan. Grades: ≥98%. CAS No. 68291-98-5. Molecular formula: C8H7N2NaO3S. Mole weight: 234.21. | |
| Zotepine | Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki = 0.69 and 2.3 nM, respectively) used as an atypical antipsychotic for the treatment of schizophrenia. Zotepine also exhibits an antagonistic effect at histamine H1 receptor (IC50 = 8.0 nM). Uses: Antipsychotic agents. Synonyms: 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine; Nipolept; Lodopin; Zoleptil; Zotepina. Grades: ≥99% by HPLC. CAS No. 26615-21-4. Molecular formula: C18H18ClNOS. Mole weight: 331.86. | |
| Z-Phe-Tyr(tBu)-diazomethylketone | Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L with selectivity for cathepsin L over cathepsin S and cathepsin B. Synonyms: Cathepsin L inhibitor III; Z-Phe-Tyr(t-Bu)-diazomethylketone. Grades: ≥98%. CAS No. 114014-15-2. Molecular formula: C31H34N4O5. Mole weight: 542.63. | |
| ZSTK474 | ZSTK474 is a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, which strongly inhibits cancer cell proliferation. Phosphoinositide 3-kinase (PI3K) is a potential target in cancer therapy. Inhibition of PI3K is believed to induce apoptosis. ZSTK474 effectively inhibited the growth of human cancer xenografts in vivo. ZSTK474 treatment suppressed the expression of nuclear cyclin D1 and Ki67 and also the expression of phospho-Akt, both of which are hallmarks of proliferation. We demonstrate that ZSTK474 induces G1arrest along with tumour suppression. Moreover, ZSTK474 suppresses the tumour growth without inducing apoptosis. Interestingly, long-term (3-month) administration of ZSTK474 maintained such increase in G1 cells and tumour suppression. ZSTK474 exerts its in vivo antitumour efficacy via G1 arrest but not via apoptosis as long as it is administered. Synonyms: ZSTK474; ZSTK-474; ZSTK 474. Grades: 0.99. CAS No. 475110-96-4. Molecular formula: C19H21F2N7O2. Mole weight: 417.421. | |
| Zuclopenthixol | Zuclopenthixol is an antagonist at D1 and D2 dopamine receptors. It also has high affinity for alpha1-adrenergic and 5-HT2 receptors, but it has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adrenergic receptors. lt is the cis-isomer of clopenthixol. It is an antipsychotic drug belonging the thioxanthene class. It was introduced in 1962 by Lundbeck. It has been listed, but is not approved for use in the United States. Uses: Zuclopenthixol is an antipsychotic drug belonging the thioxanthene class. Synonyms: Clopixol; Cisordinol; Zuclopenthixolum; 2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol; alpha-Clopenthixol; 4-[3-[(9Z)-2-Chloro-9H-thioxanthene-9-ylidene]propyl]-1-piperazineethanol; 4-[3-[(Z)-2-Chloro-9H-thioxanthen-9-ylidene]propyl]. Grades: 98%. CAS No. 53772-83-1. Molecular formula: C22H25ClN2OS. Mole weight: 400.96. | |
| Z-VA-DL-D(OMe)-FMK trifluoroacetate salt | Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor. Synonyms: Caspase-1 Inhibitor V; Z-VAD-FMK; Z-VAD(OMe)-FMK; Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone. Grades: ≥95%. Molecular formula: C22H30FN3O7·xCF3COOH. Mole weight: 467.49. | |
| Z-VAD(OH)-FMK | Z-VAD(OH)-FMK is an irreversible pan-caspase inhibitor. Synonyms: Z VAD(OH) FMK. Grades: 98%. CAS No. 161401-82-7. Molecular formula: C21H28FN3O7. Mole weight: 453.46. | |
| ZXH 3-26 | ZXH 3-26 is a potent and selective BRD4 degrader (DC50 ~ 5 nM). Synonyms: methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate; Methyl {(6S)-4-(4-chlorophenyl)-2-[(5-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}pentyl)carbamoyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate; 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-, methyl ester, (6S)-; Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate; ZXH 3-26. Grades: ≥98% by HPLC. CAS No. 2243076-67-5. Molecular formula: C38H37ClN8O7S. Mole weight: 785.27. | |
| Zymostenol | Zymostenol is an intermediate in the biosynthesis of cholesterol. It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ). Synonyms: Δ8-Cholesterol; (5α)-cholest-8-en-3β-ol; 3β-Hydroxy-5α-cholest-8(9)-ene; (3β,5α)-Cholest-8-en-3-ol. Grades: ≥95%. CAS No. 566-97-2. Molecular formula: C27H46O. Mole weight: 386.65. | |
| Z-YVAD-CMK trifluoroacetate salt | Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3. It exhibits anti-apoptotic, anti-inflammatory and neuroprotective effects. Synonyms: Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone; Caspase-1 Inhibitor IV. Grades: ≥95%. Molecular formula: C30H37ClN4O9·xCF3COOH. Mole weight: 633.09. | |
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