BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| WHI-P180 hydrochloride | WHI-P180 moderately inhibited ABCG2 function, exhibiting weak phototoxicity. The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. Synonyms: Janex 3 hydrochloride; Janex3 hydrochloride; Janex-3 hydrochloride; WHI-P 180 hydrochloride; WHIP 180 hydrochloride; WHI P 180 hydrochloride. Grades: >98%. CAS No. 153437-55-9. Molecular formula: C16H16ClN3O3. Mole weight: 333.77. |  |
| (-)-WIN 55,212-3 mesylate | (-)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor and presumably express the CB1 receptor. It also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors. Synonyms: [(11S)-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-1-ylmethanone mesylate. Grades: ≥98%. CAS No. 131543-25-4. Molecular formula: C27H26N2O3·CH3SO3H. Mole weight: 522.6. | |
| Win-62005 | Win-62005 competitively and selectively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta (Kis= 25 and 26 nM for rat heart and canine aorta, respectively). Synonyms: 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one; WIN 62005; WIN62005; WIN-62005. CAS No. 152633-54-0. Molecular formula: C12H10N4O. Mole weight: 226.23. | |
| WIN 64338 hydrochloride | WIN 64338 hydrochloride is a potent, non-peptide and competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation). Synonyms: WIN 64338 hydrochloride; WIN 64338 HCl; WIN 64338; WIN64338; WIN-64338. (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride. CAS No. 163727-74-0. Molecular formula: C45H68ClN4OP.HCl. Mole weight: 783.95. | |
| Withanolide B | Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B acts as a neuronal nitric oxide synthase (nNOS) inhibitor (Ki = 5.15 nM). Synonyms: Lycium substance B. Grades: ≥95%. CAS No. 56973-41-2. Molecular formula: C28H38O5. Mole weight: 454.6. | |
| WK88-1 | WK88-1 inhibits Hsp90, resulting in decreased expression of Hsp90 client proteins and potentially leading to decreased tumor cell growth. Synonyms: WK88-1; WK88 1; WK881. Grades: >98%. CAS No. 958888-32-9. Molecular formula: C28H42N2O6. Mole weight: 502.64. | |
| Wortmannin-Rapamycin Conjugate | Wortmannin is a potent inhibitor of PI3K enzymes, and rapamycin blocks mTOR. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Synonyms: Wortmannin-Rapamycin Conjugate; 1067892-47-0; AKOS040755180. Grades: ≥98%. CAS No. 1067892-47-0. Molecular formula: C88H131N3O23. Mole weight: 1598.9. | |
| WQ3810 | WQ3810 is a newly developed fluoroquinolone withunique substituents at the N1 and C7 positions of the quinolone ringfor the treatment of antibiotic-resistant infections. Synonyms: 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylic acid; 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isopropylamino)azetidin-1-yl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WQ-3810; WQ 3810; WQ3810. CAS No. 888032-58-4. Molecular formula: C22H22F3N5O3. Mole weight: 461.44. | |
| WT-161 | WT-161 is a potent and specific HDAC6 inhibitor (IC50 = 0.40 nM). Consistent with WT-161 mediated hyperacetylation and inhibition of hsp90 chaperone function, treatment with WT-161 increased the intracellular levels of polyubiuitylated proteins in the cultured MCL JeKo-1 and Z138 cells. WT-161 was also noted to dose-dependently deplete the levels of cyclin D1 in the cultured MCL cells. Uses: Antineoplastic agents. Synonyms: (E) -8- (2- (4- (Diphenylamino) benzylidene) hydrazinyl) -N-hydroxy-8-oxooctanamide; WT161; WT 161; WT-161. CAS No. 1206731-57-8. Molecular formula: C27H30N4O3. Mole weight: 458.55. | |
| WY 45233 succinate | WY 45233 succinate is an inhibitor of serotonin and noradrenalin reuptake (SNRI) used in the treatment of major depressive disorder (MDD). WY 45233 succinate inhibits [3H]5-HT and [3H]NE uptake (IC50 = 47.3 and 531.3 nM). Uses: The treatment of major depressive disorder. Synonyms: WY 45233 succinate; WY45233 succinate; WY-45233 succinate; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate; O-Desmethylvenlafaxine succinate; Ventab DXT; Desvenlafaxine succinate anhydrous. Grades: ≥99% by HPLC. CAS No. 448904-47-0. Molecular formula: C16H25NO2.C4H6O4. Mole weight: 381.46. | |
| WYE-125132 | WYE-125132, also known as WYE-132, is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor. WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells. Synonyms: WYE 125132, WYE-125132, WYE125132, WYE132, WYE 132, WYE-132. Grades: 0.98. CAS No. 1144068-46-1. Molecular formula: C27H33N7O4. Mole weight: 519.606. | |
| WYE-23 | WYE-23 is an inhibitor of mTOR with IC50 value of 0.45 nM. Synonyms: mTOR Inhibitor WYE-23; Methyl 4-[6-[4-(cyclopropylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1062169-46-3. Molecular formula: C26H32N8O4. Mole weight: 520.6. | |
| WYE-28 | WYE-23 is an ATP-competitive inhibitor of mTOR with IC50 value of 0.08 nM. Synonyms: Methyl 4-[6-[4-[[4- (hydroxymethyl) phenyl]carbamoylamino]phenyl]-4-morpholin-4-ylpyrazolo[3, 4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1062172-60-4. Molecular formula: C30H34N8O5. Mole weight: 586.6. | |
| WYE-354 | WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. Synonyms: WYE354; WYE-354; WYE 354. Grades: 0.98. CAS No. 1062169-56-5. Molecular formula: C24H29N7O5. Mole weight: 495.54. | |
| WYE 672 | WYE 672 is a tissue selective liver X receptor (LXR) agonist selectively binds to LXRα (IC50 >1.0 μM). Synonyms: WYE 672; WYE672; WYE-672; 3-methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxaline. Grades: 99%. CAS No. 1221265-37-7. Molecular formula: C23H17F3N2O2S. Mole weight: 442.45. | |
| WYE-687 | WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM. Synonyms: WYE687; WYE 687; WYE-687. Grades: 0.98. CAS No. 1062161-90-3. Molecular formula: C28H32N8O3. Mole weight: 528.617. | |
| WYE 687 dihydrochloride | WYE 687 is an ATP-competitive inhibitor of mTOR with IC50 value of 7 nM. It was shown to inhibit phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt. It also blocks VEGF secretion and HIF-1α expression. Synonyms: N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1702364-87-1. Molecular formula: C28H32N8O32HCl. Mole weight: 601.53. | |
| WZ-3146 | WZ-3146 is an irreversiblely inhibitor against EGFR T790M with potential anticancer activity. Synonyms: WZ3146; WZ 3146. Grades: 0.98. CAS No. 1214265-56-1. Molecular formula: C24H25ClN6O2. Mole weight: 464.954. | |
| WZ4003 | WZ4003 exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells. Synonyms: WZ4003; WZ-4003; WZ 4003. Grades: >98%. CAS No. 1214265-58-3. Molecular formula: C25H29ClN6O3. Mole weight: 496.99. | |
| WZ-8040 | WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors. Synonyms: WZ8040; WZ 8040. Grades: 0.98. CAS No. 1214265-57-2. Molecular formula: C24H25ClN6OS. Mole weight: 481.015. | |
| WZ 811 | WZ 811 is a potent CXCR2 antagonist. Synonyms: N,N'-di-2-pyridinyl-1,4-benzenedimethanamine; WZ811; WZ-811; WZ 811. CAS No. 55778-02-4. Molecular formula: C18H18N4. Mole weight: 290.36. | |
| XAC | XAC is an adenosine receptor antagonist (IC50 = 1.8 and 114 nM at A1 and A2 receptors, respectively). XAC inhibits adenosine-induced vasodilation and exhibits proconvulsant activity in vivo. Synonyms: N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C21H28N6O4.2HCl. Mole weight: 501.41. | |
| Xamoterol hemifumarate | Xamoterol hemifumarate is a third generation β1-adrenoceptor-selective partial agonist (pA2 = 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors, respectively). Synonyms: Xamoterol hemifumarate; ICI-118587 hemioxalate; ICI 118587 hemioxalate; ICI118587 hemioxalate; 1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate; Corwin; Xamoterol fumarate. Grades: ≥97% by HPLC. CAS No. 73210-73-8. Molecular formula: C16H25N3O5.1/2C4H4O4. Mole weight: 397.43. | |
| Xanomeline | Xanomeline is a Muscarinic M1 and M4 receptor agonist under the development of Eli Lilly, though it is also known to act as a M5 receptor antagonist. Xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms although gastrointestinal side effects led to a high drop-out rate in clinical trials. Recent studies showed robust improvements in verbal learning and short-term memory associated with xanomeline treatment. In Dec 1998, Phaes-III clinical trials for Alzheimer's disease in USA was discontinued. Uses: Alzheimer's disease. Synonyms: LY-246708; LY246708; LY 246708; Xanomeline; Memcor; NNC-110232; Hexyloxy-TZTP; HexyloxyTZTP;3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole. Grades: 95%. CAS No. 131986-45-3. Molecular formula: C14H23N3OS. Mole weight: 281.42. | |
| Xanomeline oxalate | Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively). It has antipsychotic-like activities in rats and Cebus monkeys. M1 selective agonists, like Xanomeline oxalate, enhance memory function and has utility in treating Alzheimer's Disease. Synonyms: LY246708; LY 246708; LY-246708; Memcor; Lumeron. Grades: >98%. CAS No. 141064-23-5. Molecular formula: C16H25N3O5S. Mole weight: 371.45. | |
| Xanthine amine congener | Xanthine amine congener (XAC) is a non-selective adenosine receptor antagonist. Synonyms: XAC; Papaxac; N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide. Grades: ≥98%. CAS No. 96865-92-8. Molecular formula: C21H28N6O4. Mole weight: 428.5. | |
| Xanthorrhizol | Xanthorrhizol is a sesquiterpenoid isolated from the rhizome of C. xanthorrhiza. It exhibits antibacterial and antifungal activity, neuroprotective activity, and anti-inflammatory activity. It inhibits the expression of ornithine decarboxylase, cyclooxygenase-2, and inducible nitric oxide synthase at concentrations as low as 0.3 μM. Synonyms: (R)-5-(1,5-Dimethyl-4-hexenyl)-o-cresol. Grades: ≥97%. CAS No. 30199-26-9. Molecular formula: C15H22O. Mole weight: 218.3. | |
| Xanthurenic acid | Xanthurenic acid acts as an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist in transfected HEK293 cells at nanomolar concentrations. It suppresses cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors. Uses: Hypolipidemic agents. Synonyms: 8-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid. Grades: ≥ 98 % by HPLC. CAS No. 59-00-7. Molecular formula: C10H7NO4. Mole weight: 205.17. | |
| XAP 044 | XAP 044 is a potent, selective and brain penetrating mGlu7 antagonist (IC50 = 88 nM). It inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. XAP 044 exhibits anti-anxiety effects in rodent models and can be potentially used in the treatment of anxiety and depression. Synonyms: XAP044; XAP 044; XAP-044; 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one. Grades: ≥98% by HPLC. CAS No. 196928-50-4. Molecular formula: C15H9IO4. Mole weight: 380.13. | |
| XCC | XCC is an adenosine receptor antagonist (Ki = 42, 68 and 1130 nM for A1, A2B and A2A receptors). Synonyms: 2-[4-(2,3,6,7-Tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetic acid. Grades: ≥98% by HPLC. CAS No. 96865-83-7. Molecular formula: C19H22N4O5. Mole weight: 386.4. | |
| XCT 790 | XCT-790 is a potent, selective ERRα antagonist/inverse agonist (IC50 = ~400 nM), displaying no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Uses: Selective errα antagonist/inverse agonist. Synonyms: XCT790; XCT 790; XCT-790; 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide; (E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide. Grades: ≥98%. CAS No. 725247-18-7. Molecular formula: C23H13F9N4O3S. Mole weight: 596.42. | |
| XD 14 | XD 14 is a BET bromodomain inhibitor (Kd = 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively). XD 14 also inhibits BRDT(1), CBP, p300 and BRDT(2) (Kd = 1.2, 1.6, 2.6 and 3.7 μM, respectively). XD 14 inhibits proliferation of HL-60 leukemia cells in vitro. Synonyms: XD14; XD 14; XD-14; 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 1370888-71-3. Molecular formula: C20H27N3O5S. Mole weight: 421.51. | |
| XE 991 dihydrochloride | XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. XE 991 blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). XE 991 increases hippocampal ACh release and enhances cognition following oral administration in vivo, suggesting to be beneficial for Alzheimer's disease therapy. Uses: Potential treatment of alzheimer's disease. Synonyms: XE991; XE 991; XE-991; LS 190926; LS190926; LS-190926; 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride. Grades: ≥99% by HPLC. CAS No. 122955-13-9. Molecular formula: C26H20N2O.2HCl. Mole weight: 449.37. | |
| XEN907 | XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for further optimization efforts in vitro. It shows no significant activity at 10 μM against a broad panel of 63 receptors and transporters. It is extensively distributed and rapidly cleared. Uses: Xen907 is used as a spirooxindole blocker. Synonyms: XEN907; XEN 907; XEN-907;1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one. Grades: >98%. CAS No. 912656-34-9. Molecular formula: C21H21NO4. Mole weight: 351.40. | |
| Xeruborbactam | Xeruborbactam is an extended-spectrum inhibitor of serine and metal-β-lactamase. Synonyms: QPX7728; QPX-7728; QPX 7728; (1aR, 7bS)-5-fluoro-2-hydroxy-1, 1a, 2, 7b-tetrahydrocyclopropa[c][1, 2]benzoxaborinine-4-carboxylic acid; Benzo[e]cycloprop[c][1,2]oxaborin-4-carboxylic acid, 5-fluoro-1,1a,2,7b-tetrahydro-2-hydroxy-, (1aR,7bS)-carboxylic acid. Grades: >98%. CAS No. 2170834-63-4. Molecular formula: C10H8BFO4. Mole weight: 221.98. | |
| XL228 | XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases. Synonyms: XL-228; XL228; XL 228. Grades: 0.98. CAS No. 898280-07-4. Molecular formula: C22H31N9O. Mole weight: 437.54. | |
| XL388 | XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Synonyms: XL388; XL-388; XL 388. Grades: 0.98. CAS No. 1251156-08-7. Molecular formula: C23H22FN3O4S. Mole weight: 455.504. | |
| XL-418 | XL-418 is a 70 kDa ribosomal protein S6 kinase and Proto oncogene protein c-akt inhibitor. It can inhibit the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). But in Dec 2007, Phase-I for Solid tumours in USA was discontinued. Uses: Solid tumours. Synonyms: XL418; XL-418; X 418; 1-(3-(4-(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-4-methyl-5-((2-(pyrrolidin-1-yl)ethyl)amino)phenyl)-4,4,4-trifluorobutan-1-one. Grades: 98%. CAS No. 871343-09-8. Molecular formula: C26H32BrF3N8O. Mole weight: 609.49. | |
| XL888 | XL888 is an ATP-competitive inhibitor of Hsp90. Through this action, specific client proteins are degraded, leading to cell cycle arrest or apoptosis. XL888 is orally bioavailable and displays efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice. Synonyms: XL888; XL 888; XL-888. Grades: >98%. CAS No. 1149705-71-4. Molecular formula: C29H37N5O3. Mole weight: 503.64. | |
| XL999 | XL999, a Spectrum Selective Kinase Inhibitor(TM) (SSKIs), is a potent inhibitor of key RTKs implicated in the development and maintenance of tumor vasculature and in the proliferation of some tumor cells. It inhibits the FGFR, VEGFR and PDGFR RTKs and exhibited excellent activity in target-specific cellular functional assays. In addition, XL999 is a potent inhibitor of FLT3, an important driver of leukemia cell proliferation in some patients with acute myelogenous leukemia (AML). In several preclinical models of human tumors, including breast, lung, colon and prostate cancer, XL999 demonstrated potent inhibition of tumor growth, and also caused regression of large well-established tumors. Phase I studies of XL999 established a maximum tolerated dose and showed evidence of tumor responses. Synonyms: XL999; XL 999; XL-999. CAS No. 705946-27-6. Molecular formula: C26H28FN5O. Mole weight: 445.532. | |
| XL PI3K/mTOR inhibitor | An orally bioactive PI3K/mTOR tyrosine kinase inhibitor. Synonyms: N-(3-(N-(3-((3,5-dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide. Grades: 99%. CAS No. 934529-30-3. Molecular formula: C31H29N5O6S. Mole weight: 599.66. | |
| XMD17-109 | Potent and selective ERK5 inhibitor; inhibits EGFR-induced ERK5 autophosphorylation (EC50 = 90 nM) and ERK5 enzymatic activity (IC50 = 162 nM). Exhibits at least 30-fold selectivity for ERK5 over LRRK2 in a cell based assay. Also selective for ERK5 over a panel of other kinases. Orally bioavailable. Synonyms: XMD17-109; XMD-17-109; XMD 17-109; XMD17109; XMD-17109; XMD 17109. Grades: >98%. CAS No. 1435488-37-1. Molecular formula: C36H46N8O3. Mole weight: 638.8. | |
| XMD8-87 | XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2), also known as Ack1 (IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). Synonyms: 2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one; ACK1-B19; EX-A1296; XMD 8-87; XMD8-87; XMD-8-87; XMD 8-87; XMD887; XMD-887; XMD 887; ACK1-B19. CAS No. 1234480-46-6. Molecular formula: C24H27N7O2. Mole weight: 445.52. | |
| XMD8-92 | XMD8-92, via inhibition of BMK1 activation, significantly induces p21 expression in cells, and mediates suppression of cancer cell proliferation. Synonyms: XMD8-92; XMD-8-92; XMD 8-92; XMD892; XMD-892; XMD 892. Grades: >98%. CAS No. 1234480-50-2. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
| XRP44X | XRP44X, under the IUPAC name [4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone, is an inhibitor of Tubulin that suppresses microtubule polymerization and indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Ras-Net (Elk-3) pathway: IC50 = 10 - 20 nM. Synonyms: XRP44X; XRP-44X; XRP 44X; XRP-44-X; XRP 44 X; [4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone; XRP44X; 729605-21-4; 1-(3-CHLOROPHENYL)-4-[(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)CARBONYL]PIPERAZINE; [4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone; 1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine; ACMC-20ejss; MLS006010688; SCHEMBL6259088; CHEMBL3184174; CTK5D7160; DTXSID20438402; NPHPNBGYPKBDDB-UHFFFAOYSA-N; ZINC3987355; MFCD12828749; AKOS024457429; TRA0076028; NCGC00346805-01; AK174344; CJ-11238; HE383857; KB-62004; SMR004701669(4-(3-chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone; [4-(3-chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)-methanone; [4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone; PIPERAZINE, 1-(3-CHLOROPHENYL)-4-[(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)CARBONYL]-; XRP44X|1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine. CAS No. 729605-21-4. Molecular formula: C21H21ClN4O. Mole weight: 380.87. | |
| XY 018 | XY 018 is a RORγ antagonist with EC50 value of 190 nM. It suppresses androgen receptor expression in prostate cancer cell lines. It also inhibits growth of tumors in androgen receptor-positive xenograft models. Synonyms: XY-018; XY018; N-[2'-Fluoro-4'-[2, 2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1, 1'biphenyl]-4-yl]-2-nitrobenzeneacetamide. Grades: ≥98% by HPLC. CAS No. 1873358-87-2. Molecular formula: C23H15F7N2O4. Mole weight: 516.36. | |
| XY1 | XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 μM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. Synonyms: XY1; XY-1; XY 1. Grades: 98%. CAS No. 1624117-53-8. Molecular formula: C17H19N3O2. Mole weight: 297.36. | |
| Xylometazoline HCl | Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Synonyms: Xylometazoline HCl; xylomethazoline. Brand name: Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal. Grades: >98%. CAS No. 1218-35-5. Molecular formula: C16H24N2.HCl. Mole weight: 280.84. | |
| Y 134 | Y 134 is a selective estrogen receptor modulator (SERM) with selectivity for ERα over ERβ (Ki = 0.09 and 11.31 nM, respectively). It has no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Y 134 suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells. Synonyms: Y 134; Y134; Y-134; [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone. Grades: ≥98% by HPLC. CAS No. 849662-80-2. Molecular formula: C28H28N2O3S. Mole weight: 472.6. | |
| Y15 | Y15 is a novel small molecule FAK phosphorylation inhibitor. It is a direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397. Besides, it promotes cell detachment and inhibits cell adhesion of cells in culture. It has been used to demonstrate a role for FAK in the regulation of aortic stiffness. Synonyms: 1,2,4,5-benzenetetramine tetrahydrochloride; Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15 FAK Inhibitor 14. Grades: >98%. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01. | |
| Y-26763 | Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Y-26763 inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Y-26763 exhibits antihypertensive effects on spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo. Synonyms: Y-26763; Y 26763; Y26763. N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide. Grades: ≥98% by HPLC. CAS No. 127408-31-5. Molecular formula: C14H16N2O4. Mole weight: 276.29. | |
| Y-27152 | Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763. It was demonstrated ability to produce long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. Synonyms: Y 27152; Y-27152; Y27152. N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide. Grades: ≥98% by HPLC. CAS No. 127408-30-4. Molecular formula: C21H22N2O4. Mole weight: 366.41. | |
| Y-29794 | Y-29794, a novel orally non-peptide PPCE inhibitor, has shown to be able to prevent amyloid-like deposition in senescence-accelerated mice. Y-29794 exhibited potent inhibitory activity with an IC50 = 3.0 nM for both brain crude extract and partially purified enzyme fraction. Synonyms: Methanone, [2-[[8-(dimethylamino)?octyl]?thio]?-6-(1-methylethyl)?-3-pyridinyl]?-2-thienyl-; [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone; 2-[(8-Dimethylaminooctyl)thio]-3-(2-thenoyl)-6-isopropylpyridine; 2-[(8-Dimethylaminooctyl)thio]-6-isopropyl-3-pyridyl 2-thienyl ketone; Y 29794; Y29794; Y-29794. CAS No. 129184-48-1. Molecular formula: C23H34N2OS2. Mole weight: 418.66. | |
| Y-29794 Oxalate | Y-29794 Tosylate, a novel orally non-peptide PPCE inhibitor, has shown to be able to prevent amyloid-like deposition in senescence-accelerated mice. Y-29794 exhibited potent inhibitory activity with an IC50 of 3.0 nM for both brain crude extract and partially purified enzyme fraction. Synonyms: Y-29794 Tosylate; Y 29794 Tosylate; Y29794 Tosylate; [2-[8-(dimethylamino)octylsulfanyl]-6-propan-2-ylpyridin-3-yl]-thiophen-2-ylmethanone; oxalic acid; 2-(8-dimethylaminooctylthio)-6-isopropyl-3-pyridyl-2-thienyl ketone citrate; Y 29794; Y-29794; Y29794; Y-29794 OXALATE; 129184-48-1; CTK8F0584; HMS3268I17; AKOS024456715; Y-29794 oxalate|[2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone oxalate. CAS No. 146794-84-5. Molecular formula: C23H34N2OS2.C2H2O4. Mole weight: 508.69. | |
| Y-33075 | Y-33075, also called as SNJ-1656, a well-characterized ROCK inhibitor, inhibits more potently ROCK by about 30 times than Y-27632, a common specific ROCK inhibitor (IC50= 3.6nM). Synonyms: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamideSNJ-1656; Y-39983; Y-33075; SNJ 1656; Y 39983; Y 33075; SNJ1656; Y39983; Y33075. CAS No. 199433-58-4. Molecular formula: C16H16N4O. Mole weight: 280.32. | |
| Y 700 | Y 700 is a xanthine oxidase (XAO) inhibitor. Synonyms: Niraxostat; Y 700; Y-700; Y700. 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]pyrazole-4-carboxylic acid. Grades: 99%. CAS No. 206884-98-2. Molecular formula: C16H17N3O3. Mole weight: 299.32. | |
| YIL 781 | YIL 781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM) with no significant affinity for the motilin receptor (Ki = 6 μM). YIL 781 inhibits ghrelin to reduce insulin secretion both in vivo and in vitro. YIL 781 may be beneficial for the treatment of obesity and diabetes. Uses: Potential treatment of obesity and diabetes. Synonyms: YIL 781; YIL781; YIL-781; 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone; KB-276128; KB 276128; KB276128. Grades: ≥98% by HPLC. CAS No. 875258-85-8. Molecular formula: C24H28FN3O2. Mole weight: 409.51. | |
| YJC-10592 | YJC-10592 is a CC chemokine receptor 2 (CCR2) antagonist (IC50 value 1.12 μM). Synonyms: YJC-10592; YJC 10592; YJC10592. Grades: 98%. CAS No. 1226894-87-6. Molecular formula: C27H31ClF3N5O3. Mole weight: 566.01. | |
| YK 3-237 | YK 3-237 is a sirtuin-1 (SIRT1) activator. YK 3-237 inhibits proliferation of breast cancer cell lines expressing mutant p53, and induces G2/M cell cycle arrest in triple negative breast cancer cells (TNBCs) in vitro. Synonyms: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid. Grades: ≥98% by HPLC. CAS No. 1215281-19-8. Molecular formula: C19H21BO7. Mole weight: 372.18. | |
| YLF-466D | YLF466D activated recombinant human α1β1γ1, α2β1γ1 and rat liver AMPK. It also activated AMPK α-subunit truncations containing an autoinhibitory domain(AID) and exhibited additivity with AMP and A-769662. Molecular docking of YLF466D with the S pombe AMPKa (25-351) suggests it may bind in the cleft between the kinase domain and the AID antagonizing the auto-inhibition distinct from AMP and A-769662. Incubation of YLF466D in Hela cells activated cellular AMPK without detectable changes in AMP:ATP ratio, proving AMPK was allosterically activated by YLF466D. YLF466D activated cellular AMPK in both L6 myotubes and HepG2 cells with evoking intracellular AMP:ATP ratio accompanied by depolarizing mitochondria membrane potential, but has no effect on the dephosphorylation of PP2Cα on AMPK. Thus, YLF466D activated cellular AMPK through dual mechanisms. Functional studies shown YLF466D stimulated glucose uptake in L6 myotubes, decreased glucose output and lipid content in hepatocyte. Acute and chronic treatment of YLF466D on diabetic db/db mice and diet induced obese mice improved metabolic parameters. Synonyms: C24; YLF 466D; YLF466D. Grades: >98%. CAS No. 1273323-67-3. Molecular formula: C29H20ClNO3. Mole weight: 465.93. | |
| YM 202074 | YM 202074 is a high affinity and selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM 202074 binds to an allosteric site of the rat mGlu1 receptor (Ki = 4.8 nM) and inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Synonyms: YM 202074; YM202074; YM-202074; N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate. Grades: ≥99% by HPLC. CAS No. 299900-84-8. Molecular formula: C22H30N4O2S.3/2C4H4O4. Mole weight: 588.67. | |
| YM 230888 | YM 230888 is a selective mGlu1 antagonist (Ki = 13 nM) that inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM). YM 230888 displays antinociceptive and analgesic effects in vitro, and exhibits no significant sedative effect on locomotor activity. Synonyms: YM 230888; YM230888; YM-230888; 4-(Cycloheptylamino)-N-[[(2R)-tetrahydro-2-furanyl]methyl]-thieno[2,3-d]pyrimidine-6-methanamine; N-cycloheptyl-6-[[[(2R)-oxolan-2-yl]methylamino]methyl]thieno[2,3-d]pyrimidin-4-amine. Grades: ≥99% by HPLC. CAS No. 446257-23-4. Molecular formula: C19H28N4OS. Mole weight: 360.52. | |
| YM-244769 dihydrochloride | YM-244769 dihydrochloride is a potent Na+/Ca2+ exchange inhibitor. It preferentially inhibits NCX3 (IC50 = 18 nM). CAS No. 1780390-65-9. Molecular formula: C26H24Cl2FN3O3. Mole weight: 516.39. | |
| YM 26734 | YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) with a broad inhibitory profile to several sPLA2s (IC50 = 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE, respectively). YM 26734 displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. YM 26734 is used to ameliorates local inflammatory responses in TPA-induced mouse ear edema. Synonyms: YM 26734; YM26734; YM-26734; 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone; 1-[3-dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]phenyl]dodecan-1-one. Grades: ≥95% by HPLC. CAS No. 144337-18-8. Molecular formula: C45H62O8. Mole weight: 730.97. | |
| YM 298198 dihydrochloride | YM 298198 dihydrochloride is a selective mGluR-1 antagonist. In vivo, YM 298198 exhibits an antinociceptive effect in hyperalgesic mice. Synonyms: YM 298198 dihydrochloride; YM298198 dihydrochloride; YM-298198 dihydrochloride; 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzoimidazole-2-carboxamide dihydrochloride. Grades: 99%. CAS No. 299901-50-1. Molecular formula: C18H22N4OS.2HCl. Mole weight: 415.38. | |
| YM 298198 hydrochloride | Cas No. 1216398-09-2. | |
| YM-46303 | YM-46303 is an mAChR antagonist which had a binding affinity of 0.39 nM to M3-receptors. YM-46303 exhibits the highest affinities for M1 and M3 receptors. YM-46303 had been in phase II clinical trials by Astellas Pharma for the treatment of urinary incontinence. Synonyms: YM-46303; YM-46303; YM-46303; 1-azabicyclo[2.2.2]octan-4-yl N-(2-phenylphenyl)carbamate;hydrochloride. CAS No. 171722-81-9. Molecular formula: C20H23ClN2O2. Mole weight: 358.86. | |
| YM 90709 | YM 90709 is an IL5 receptor antagonist. Synonyms: YM-90709; YM 90709; YM90709. 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline. CAS No. 163769-88-8. Molecular formula: C22H21N3O2. Mole weight: 359.43. | |
| YM 90K hydrochloride | YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki = 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors, respectively). YM 90K hydrochloride displays neuroprotective activity that delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Synonyms: YM90K hydrochloride; YM 90 K hydrochloride; YM-90-K hydrochloride; YM90K HCl; YM-90-K HCl; YM 90 K HCl; 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride. Grades: ≥99% by HPLC. CAS No. 154164-30-4. Molecular formula: C11H7N5O4.HCl. Mole weight: 309.67. | |
| YS-035 hydrochloride | YS-035 hydrochloride is a Ca2+ blocker that strikingly prolongs cardiac action potentials via inhibiting pacemaker current and K+ outward currents. Synonyms: YS-035 hydrochloride; YS 035 hydrochloride; YS035 hydrochloride; N,N-Bis-(3,4-dimethoxyphenylethyl)-N-methylamine hydrochloride. CAS No. 89805-39-0. Molecular formula: C21H29NO4.HCl. Mole weight: 395.93. | |
Our database is helping our users find suppliers everyday.
