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| Product | Description | |
|---|---|---|
| U89232 | U89232, a cardioselective cyanoguanidine analog of cromakalim, appears to be a cardioselective KATP channel opener. Synonyms: 1-cyano-2-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-(2-methylbutan-2-yl)guanidine; Guanidine, N-cyano-N'-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-N''-(1,1-dimethylpropyl)-, trans-; trans-N-cyano-N'-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-N''-(1,1-dimethylpropyl)guanidine; U 89232; U-89232. CAS No. 134017-78-0. Molecular formula: C19H25N5O2. Mole weight: 355.43. |  |
| U 89843A | U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors. U 89843A exhibits sedative activity following i.v. administration without losing "righting reflex" and also displays antioxidant activity. Synonyms: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride. Grades: ≥99% by HPLC. CAS No. 157013-85-9. Molecular formula: C16H23N5.HCl. Mole weight: 321.85. | |
| U 90042 | U 90042 is a GABAA receptor ligand binding to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki = 7.8, 9.5 and 11.0 nM, respectively). U 90042 potentiates GABA-induced chloride currents in α6β2γ2 receptors. U 90042 is used as a sedative/hypnotic. Uses: Sedative/hypnotic. Synonyms: U 90042; U90042; U-90042; 11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline; ACMC-20ejs3. Grades: ≥99% by HPLC. CAS No. 134516-99-7. Molecular formula: C17H13ClN6O. Mole weight: 352.78. | |
| U91356 | U91356 exhibits good dopaminergic agonist activity, and has improved metabolic stability and oral bioavailability in the rat and monkey. Synonyms: 5-propylamino-5,6-dihydro-4H-imidazo(4,5,1-ij)quinolin-2(1H)-one; U 91356; U 91356; U-91356; U 91356A; U-91356; U-91356A; U91356A. CAS No. 152886-85-6. Molecular formula: C13H17N3O. Mole weight: 231.29. | |
| U 92016A | U 92016A is an orally bioactive 5-HT1A full agonist with high intrinsic activity. Hypothermia, hypotension and 5-HT behavioral syndrome are caused by administration of U 92016A. Synonyms: U 92016A; U92016A; U-92016A; (8R)-8-(dipropylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile hydrochloride. Grades: 99%. CAS No. 149654-41-1. Molecular formula: C19H25N3.HCl. Mole weight: 331.88. | |
| U-93631 | U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors. Synonyms: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester; U93631, U-93631, U 93631. CAS No. 152273-12-6. Molecular formula: C17H21N3O2. Mole weight: 299.37. | |
| U 99194 maleate | U 99194 maleate is a potent and selective dopamine D3 antagonist (Ki = 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors, respectively). Synonyms: U 99194 maleate; U99194 maleate; U-99194 maleate; 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate; 5,6-Dimethoxy-2-(di-n-propylamino)indan maleate. Grades: ≥98% by HPLC. CAS No. 234757-41-6. Molecular formula: C17H27NO2.C4H4O4. Mole weight: 393.48. | |
| UA 62784 | UA 62784, under the IUPAC name 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one, a cytotoxic microtubule inhibitor in vitro, causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. It is also a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. Synonyms: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one; UA62784, UA62784, UA 62784; 313367-92-9; 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one; AC1MPDKY; Oprea1_740865; SCHEMBL14765347; CTK8E8877; DTXSID20391982; ZINC1512677; AKOS024458074; PL053830; 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one; 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one; UA 62784|4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one. CAS No. 313367-92-9. Molecular formula: C23H15NO3. Mole weight: 353.37. | |
| UAB30 | UAB30 is a low-toxicity retinoid X receptor-selective agonist selective for the binding and activation of RXR's over RAR' s. UAB30 is highly effective in the prevention of breast cancers in a rat model. Synonyms: (2E,4E,6Z,8E)-8-(3,4-dihydro-2H-naphthalen-1-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid; (9Z)-UAB30; 8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; 9-cis-UAB30; 9cUAB30; 9cUAB30, 9-cis UAB30, (all-E)-UAB 30, all-trans-UAB 30, UAB30, UAB-30, UAB 30; 9-cis-UAB30. Grades: >98%. CAS No. 205252-59-1. Molecular formula: C20H22O2. Mole weight: 294.39. | |
| UB 165 fumarate | UB 165 fumarate is a full agonist at α3β2- and a weak partial agonist at α4β2- containing nAChRs (Ki = 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε, respectively). Synonyms: UB 165 fumarate; UB165 fumarate; UB-165 fumarate; 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate. Grades: ≥99% by HPLC. CAS No. 200432-86-6. Molecular formula: C13H15ClN2.C4H4O4. Mole weight: 350.8. | |
| UBP1112 | UBP1112 is a selective group III mGlu receptor antagonist (apparent Kd=5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors). Synonyms: UBP1112; UBP 1112; UBP-1112; α-Methyl-3-methyl-4-phosphonophenylglycine; 2-amino-2-(3-methyl-4-phosphonophenyl)propanoic acid. Grades: ≥99% by HPLC. CAS No. 339526-74-8. Molecular formula: C10H14NO5P. Mole weight: 259.2. | |
| UBP 282 | UBP 282 is an AMPA and kainate receptor antagonist. UBP 282 inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres. Synonyms: UBP-282, UBP 282, UBP282; (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid; VBP. Grades: ≥98% by HPLC. CAS No. 544697-47-4. Molecular formula: C15H15N3O6. Mole weight: 333.3. | |
| UC 112 | UC-112 is an IAP inhibitor (IC50 values from 0.7 - 3.4 μM). UC-112 also potently inhibits the growth of P-glycoprotein. Uses: Iap inhibitor. Synonyms: UC-112; UC 112; UC112; 5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol; (Z,6R)-2-methyl-6-[(5R,9R,10R,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hept-2-enoic acid. Grades: ≥98%. CAS No. 383392-66-3. Molecular formula: C22H24N2O2. Mole weight: 348.44. | |
| UCB 35625 | UCB 35625 is a potent CCR1 and CCR3 antagonist. Synonyms: UCB35625, UCB 35625, UCB-35625; 1,4-TRANS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE. CAS No. 301648-08-8. Molecular formula: C30H37Cl2IN2O2. Mole weight: 655.44. | |
| UCL 1684 | UCL 1684 is a potent and nonpeptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). UCL 1684 was shown to block hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells (IC50 = 762 and 364 pM, respectively). Synonyms: UCL-1684 Dibromide; UCL 1684 Dibromide; UCL1684 Dibromide; UCL-1684 Br; UCL 1684 Br; UCL1684 Br; 6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide. Grades: ≥97% by HPLC. CAS No. 199934-16-2. Molecular formula: C34H30Br2N4. Mole weight: 654.44. | |
| UCL 2077 | UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. UCL 2077 exhibits no effect on Ca2+ currents or the time course of sAHP/sIAHP. It also inhibits KCNQ1 and KCNQ2. Synonyms: UCL2077, UCL 2077, UCL-2077; N-Trityl-3-pyridinemethanamine; (3-Triphenylmethylaminomethyl)pyridine. Grades: ≥99% by HPLC. CAS No. 918311-87-2. Molecular formula: C25H22N2. Mole weight: 350.46. | |
| UCM 707 | UCM 707 is a potent endocannabinoid transport inhibitor (IC50 = 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH, respectively). UCM 707 potentiates hypokinetic and antinociceptive effects of anandamide in vivo. Synonyms: UCM 707; UCM707; UCM-707; (5Z,8Z,11Z,14Z)-N-(3-Furanylmethyl)-5,8,11,14-eicosatetraenamide; N-(furan-3-ylmethyl)icosa-5,8,11,14-tetraenamide. CAS No. 390824-20-1. Molecular formula: C25H37NO2. Mole weight: 383.57. | |
| UDM-002555 | UDM-002555 is a small-molecule and selective antagonist of protease-activated receptor-4 (PAR-4). It can suppress the activation of platelet in dose manner. In combination with aspirin, it inhibited arterial thrombosis with limited impact on hemostasis in cynomolgus monkeys. Uses: The potential treatment of arterial thrombosis. Synonyms: UDM-002555; UDM 002555; UDM002555. | |
| UF010 | UF-010 is a Class I HDAC inhibitor, inhibiting proliferation of a range of cancer cell lines. Uses: Class i hdac inhibitor. Synonyms: UF-010, UF 010, UF010; 4-bromo-N'-butylbenzohydrazide. Grades: ≥98%. CAS No. 537672-41-6. Molecular formula: C11H15BrN2O. Mole weight: 271.16. | |
| (+)-UH 232 maleate | (+)-UH 232 maleate is a dopamine D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay) that preferentially effects on central dopamine autoreceptors. (+)-UH 232 maleate significantly promotes dopamine synthesis and turnover. (+)-UH 232 maleate is also a dopamine D3 partial agonist. Synonyms: cis-(+)-5-Methoxy-1-methyl-2-(di-N-propylamino)tetralin maleate; SR-01000597860. CAS No. 1217473-50-1. Molecular formula: C18H29NO.C4H4O4. Mole weight: 391.51. | |
| UK-1745 | UK-1745, an indole derivative, has been found to be a Calcium channel antagonist that was once studied in the treatment of arrhythmias as well as heart failure. Synonyms: 2-Aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo(2,3-e)indole-7-one hydrochloride; CTK0H6059; UK 1745; UK1745; UK-1745. Grades: 98%. CAS No. 170684-14-7. Molecular formula: C16H23ClN2O2. Mole weight: 310.82. | |
| UK 356618 | UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM) with selectivity over a range of MMPs (IC50 = 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1, respectively). Synonyms: UK-356618, UK356618, UK356618; N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine. Grades: ≥95% by HPLC. CAS No. 230961-08-7. Molecular formula: C34H43N3O4. Mole weight: 557.72. | |
| UK 370106 | UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 = 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14, respectively). UK 370106 inhibits fibronectin cleavage (IC50 = 320 nM), and substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers. Uses: The treatment of chronic dermal ulcers. Synonyms: UK 370106; UK370106; UK-370106; (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid; (3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid. Grades: ≥95% by HPLC. CAS No. 230961-21-4. Molecular formula: C35H44N2O5. Mole weight: 572.73. | |
| UK-371804 HCl | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor. Study in vitro showed that it inhibited exogenous uPA in human chronic wound fluid (IC50=0.89 mM); In a porcine acute excisional wound model, it penetrated into pig wounds and suppressed exogenous uPA activity. UK-371804 is promisingly to be used for the treatment of chronic dermal ulcers. Synonyms: UK-371804 HCl; UK 371804 HCl; UK371804 HCl; SCHEMBL6437767; 2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid hydrochloride. Grades: 99.56 %. CAS No. 256476-36-5. Molecular formula: C14H16ClN5O4S.HCl. Mole weight: 422.29. | |
| UK 432097 | UK 432097 is a potent and selective A2A-adenosine receptor agonist for the treatment of chronic obstructive pulmonary disease (category Allergy/Respiratory). Synonyms: UK-432097, UK432097, UK 432097; 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide. Grades: 99%. CAS No. 380221-63-6. Molecular formula: C40H47N11O6. Mole weight: 777.87. | |
| UK-5099 | UK-5099 is a potent inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC). It inhibits pyruvate-dependent oxygen consumption. Synonyms: PF-1005023; PF 1005023; PF1005023; UK-5099, UK 5099, UK5099. Grades: >98%. CAS No. 56396-35-1. Molecular formula: C18H12N2O2. Mole weight: 288.3. | |
| UK 59811 hydrochloride | UK 59811 is a calcium channel blocker that inhibits CaVAb. Synonyms: UK 59811 HCl; UK-59811 hydrochloride; UK-59811 HCl; UK59811 hydrochloride; UK59811 HCl; 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C22H29BrN2O5·HCl. Mole weight: 517.84. | |
| Ulixertinib HCl | Ulixertinib, also known as BVD-523 and VRT752271 is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. Synonyms: (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide hydrochloride.; BVD-523; BVD 523; BVD523; VRT752271; VRT752271; VRT 752271; Ulixertinib hydrochloride. CAS No. 1956366-10-1. Molecular formula: C21H23Cl3N4O2. Mole weight: 469.79. | |
| ULK-101 | ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. It suppresses autophagy and sensitizes cancer cells to nutrient stress. Synonyms: ULK 101; ULK101; N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide. CAS No. 2443816-45-1. Molecular formula: C22H16F4N4OS. Mole weight: 460.45. | |
| UM-164 | UM-164 is an inhibitor of Src and p38 MAPK kinases with Kds values of 2.7, 2.2, and 5.5 nM for c-Src, p38α, and p38β, respectively. It inhibits cell growth in a panel of triple-negative breast cancer (TNBC) cell lines (IC50s = 6.1-260 nM) and in a patient-derived TNBC cell line (IC50 = 320 nM). Uses: Protein kinase inhibitors. Synonyms: DAS-DFGO-II; 2-[[6-[4- (2-hydroxyethyl) piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-N-[2-methyl-5-[[3- (trifluoromethyl) benzoyl]amino]phenyl]-1, 3-thiazole-5-carboxamide. Grades: ≥98%. CAS No. 903564-48-7. Molecular formula: C30H31F3N8O3S. Mole weight: 640.68. | |
| UMB-32 | UMB-32 is an inhibitor of the BET bromodomain BRD4 (Kd = 550 nM; IC50 = 637 nM) and the bromodomain-containing transcription factor TAF1 (Kd = 560 nM) and TAF1L (Kd = 1.3 μM). Synonyms: N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine. Grades: ≥98%. CAS No. 1635437-39-6. Molecular formula: C21H23N5O. Mole weight: 361.4. | |
| UMI-77 | UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Synonyms: UMI-77, UMI77, UMI 77. Grades: >98%. CAS No. 518303-20-3. Molecular formula: C18H14BrNO5S2. Mole weight: 468.34. | |
| UNBS5162 | UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Synonyms: [2-[2-(dimethylamino)ethyl]-1,3-dioxobenzo[de]isoquinolin-5-yl]urea; UNBS 5162; UNBS-5162; UNBS5162. CAS No. 956590-23-1. Molecular formula: C17H18N4O3. Mole weight: 326.35. | |
| UNC0224 | The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase). Synonyms: UNC0224; UNC-0224; UNC 0224; 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine. Grades: >98%. CAS No. 1197196-48-7. Molecular formula: C26H43N7O2. Mole weight: 485.67. | |
| UNC0321 | UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date. Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth, and the dimethylation of p53 K373 results in the inactivation of p53. Synonyms: UNC0321, UNC-0321, UNC 0321, CHEMBL1214066, CHEBI:785916, UNC0321 (trifluoroacetate salt), NCGC0018778901, KB81388. Grades: >98%. CAS No. 1238673-32-9. Molecular formula: C27H45N7O3. Mole weight: 515.69. | |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. Synonyms: UNC0379, UNC-0379, UNC 0379. Grades: 0.98. CAS No. 1620401-82-2. Molecular formula: C23H35N5O2. Mole weight: 413.566. | |
| UNC0379 trifluoroacetate | UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. Synonyms: UNC-0379 trifluoroacetate; UNC 0379 trifluoroacetate; UNC0379 trifluoroacetate. Grades: >98%. CAS No. 1620401-83-3. Molecular formula: C25H36F3N5O4. Mole weight: 527.58. | |
| UNC-0631 | UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM. Synonyms: UNC0631, UNC 0631, UNC-0631. CAS No. 1320288-19-4. Molecular formula: C37H61N7O2. Mole weight: 635.942. | |
| UNC0642 | UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. Synonyms: UNC0642; UNC-0642; UNC 0642. Grades: 98%. CAS No. 1481677-78-4. Molecular formula: C29H44F2N6O2. Mole weight: 546.71. | |
| UNC0646 | UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. Synonyms: UNC0646, UNC 0646, UNC-0646. Grades: 0.98. CAS No. 1320288-17-2. Molecular formula: C36H59N7O2. Mole weight: 621.915. | |
| UNC 2399 | | |
| UNC 2400 | UNC 2400 is a negative control of UNC 1999 that displays 1000-fold lower potency than active analog (IC50 = 62 and >200 μM for EZH1 and EZH2, respectively). Synonyms: UNC2400; UNC-2400; UNC 2400; N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 1433200-49-7. Molecular formula: C35H47N7O2. Mole weight: 597.79. | |
| UNC 669 | (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT). Synonyms: UNC669; UNC-669. Grades: >98%. CAS No. 1314241-44-5. Molecular formula: C15H20BrN3O. Mole weight: 338.24. | |
| UNC 9994 hydrochloride | UNC 9994 hydrochloride is a β-arrestin-biased functionally selective dopamine D2 receptor (D2R) agonist (Ki value 30 nM; EC50 value 50 nM in β-arrestin-2 recruitment assay) with antipsychotic activity in vivo. Synonyms: UNC 9994 hydrochloride; UNC9994 hydrochloride; UNC-9994 hydrochloride; 5-[3-[4-(2,3-dichlorophenyl)piperidin-1-yl]propoxy]-1,3-benzothiazole hydrochloride. Grades: 99%. CAS No. 2108826-33-9. Molecular formula: C21H22Cl2N2OS.HCl. Mole weight: 457.84. | |
| UoS 12258 | UoS 12258 is a positive allosteric modulator of AMPA receptors with pEC50 value of 5.2. Synonyms: N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide. Grades: ≥98% by HPLC. CAS No. 875927-64-3. Molecular formula: C17H19FN2O2S. Mole weight: 334.41. | |
| UP202-56 | UP202-56, an adenosine analogue, selectively acts via A1 receptors to significantly decrease noxiously-evoked spinal c-Fos protein expression. Synonyms: 2-cyclopropyl-1-[(2S,3S,4R,5R)-5-[6-[2-[1-[(2,5-dimethylphenyl)methyl]-5-methylindol-3-yl]ethylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]ethanone. CAS No. 163838-04-8. Molecular formula: C33H37N7O4. Mole weight: 595.69. | |
| UP5 | UP5 is an exemplary inhibitor, exerting its potency by specifically targeting cyclin-dependent kinase 1 (CDK1) within the dynamic landscape of the biomedical industry. Offering a paradigm shift in the research of diverse cancer forms, including colorectal and breast malignancies, UP5 brilliantly orchestrates a multifaceted approach. Synonyms: P1-(Adenosine-5'-P5-(uridine-5')pentaphosphate; [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate. Molecular formula: C19H28N7O24P5. Mole weight: 893.3. | |
| UPC-K-005 | UPC-K-005 is a novel small-molecule inhibitor of a new allosteric site in p38α (IC50 = 13 mcM), which is the binding site for MAPK-activated protein kinase 2 (MK2). Researchers found that UPC-K-005 inhibits both the p38α peptide substrate and ATF2 protein substrate in a dose-response manner, which indicated that they are more universal inhibitors. Uses: Inhibitor of a new allosteric site in p38&alpha. Synonyms: UPC-K-005; 896842-60-7; SCHEMBL17903201; AKOS005505861. Molecular formula: C21H25N7OS. Mole weight: 423.5. | |
| UPF 1069 | UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.PARP activity is evaluated by utilizing commercially available recombinant bovine PARP-1 and mouse PARP-2. Briefly. Synonyms: UPF-1069, UPF1069, UPF 1069. Grades: >98%. CAS No. 1048371-03-4. Molecular formula: C17H13NO3. Mole weight: 279.29. | |
| UR 1102 | UR 1102 is an inhibitor of the renal urate transporter URAT1. UR 1102 effectively increases the fractional excretion of urinary uric acid, and reduces plasma uric acid. It is promisingly used as a therapeutic for gout or hyperuricemia with an enhanced pharmacokinetic profile. Synonyms: UR 1102; UR1102; UR-1102; (3,5-dibromo-4-hydroxyphenyl)(2,3-dihydro-4H-pyrido[4,3-b]-1,4-oxazin-4-yl)methanone. Grades: 98%. CAS No. 1198153-15-9. Molecular formula: C14H10Br2N2O3. Mole weight: 414.05. | |
| Urapidil HCl | Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Synonyms: Urapidil hydrochloride; Urapidil HCl; 64887-14-5; Urapidil (hydrochloride); PVU92PZO12; DTXSID2045812; NCGC00094502-01; Ebrantil (TN); 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione; hydrochloride; DTXCID0025812; 6-((3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride; 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride; SMR000058525; SR-01000075295; CAS-64887-14-5. Grades: >98%. CAS No. 64887-14-5. Molecular formula: C20H29N5O3·HCl. Mole weight: 423.94. | |
| URB447 | URB447 is a mixed central cannabinoid (CB1) receptor antagonist/peripheral cannabinoid (CB2) receptor agonist with IC50 values of 313 and 41 nM, respectively. Synonyms: URB-447; URB 447; [4-amino-1-[(4-chlorophenyl)methyl]-2-methyl-5-phenylpyrrol-3-yl]-phenylmethanone. Grades: ≥98%. CAS No. 1132922-57-6. Molecular formula: C25H21ClN2O. Mole weight: 400.9. | |
| URB597 | URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1. Synonyms: URB597, URB-597, URB 597, KDS-4103, KDS4103, KDS 4103. Grades: >98%. CAS No. 546141-08-6. Molecular formula: C20H22N2O3. Mole weight: 338.4. | |
| URB937 | URB937 is a potent, peripheral fatty acid amide hydrolase (FAAH) inhibitor with IC50 value of 26.8 nM. It was shown to reduce prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats. Synonyms: URB-937; URB 937; [3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate. Grades: ≥95%. CAS No. 1357160-72-5. Molecular formula: C20H22N2O4. Mole weight: 354.4. | |
| Urelumab | A fully human IgG4 monoclonal antibody developed for the treatment of cancer and solid tumors targets the CD137 receptor. It specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. Synonyms: BMS - 663513; BMS 663513; BMS663513. CAS No. 934823-49-1. | |
| Urocortin III (human) trifluoroacetate salt | Urocortin III is a neuropeptide hormone and a member of the corticotropin-releasing factor (CRF) family. Urocortin III is a highly selective agonist of the CRF2 receptor and does not show affinity for the CRF binding protein. Grades: ≥95%. Molecular formula: C185H307N53O50S2·xCF3COOH. Mole weight: 4137.88. | |
| Urocortin III (mouse) trifluoroacetate salt | Urocortin III is a neuropeptide hormone and a member of the corticotropin-releasing factor (CRF) family. Urocortin III is a highly selective agonist of the CRF2 receptor and does not show affinity for the CRF binding protein. Grades: ≥95%. Molecular formula: C186H311N51O53S2·xCF3COOH. Mole weight: 4173.90. | |
| Urocortin II (mouse) trifluoroacetate salt | Urocortin II is a neuropeptide hormone that is a member of the corticotropin-releasing factor (CRF) family. Urocortin II is a highly selective agonist of the CRF2 receptor and does not show affinity for the CRF binding protein. Grades: ≥95%. Molecular formula: C187H320N56O50·xCF3COOH. Mole weight: 4152.89. | |
| Urotensin I (white sucker) trifluoroacetate salt | Urotensin I is a naturally occurring peptide and a member of the corticotropin-releasing factor (CRF) family. It binds to recombinant human CRF1 and rat CRF2 receptors with Ki values of 0.7 and 22.9 nM, respectively. It has been shown to decrease blood pressure in the rat. Grades: ≥95%. Molecular formula: C210H340N62O67S2·xCF3COOH. Mole weight: 4869.46. | |
| UR-PI376 | This active molecular is a imidazolylpropylguanidine type compound as a hH4R agonist (histamine H4 receptor agonist) showing negligible hH1R and hH2R activities and high selectivity over the hH3R (pKB = 6.00, alpha = -0.28). Synonyms: UR-PI376, UR-PI-376, UR-PI 376, URPI376, URPI-376, URPI 376; 1-cyano-2-[4-(1H-imidazol-5-yl)butyl]-3-(2-phenylsulfanylethyl)guanidine. Grades: 98%. CAS No. 1192559-94-6. Molecular formula: C17H22N6S. Mole weight: 342.47. | |
| Urumin trifluoroacetate salt | Urumin is a peptide originally isolated from the skin of Hydrophylax bahuvistara (South Indian frog). It has been found to be effective against human influenza A viruses. Synonyms: Urumin TFA salt. Grades: ≥95%. Molecular formula: C129H198N42O35S2·xCF3COOH. Mole weight: 2961.37. | |
| USP7-IN-1 | USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM. Synonyms: USP7-IN-1; USP7 IN 1. Grades: >98%. CAS No. 1381291-36-6. Molecular formula: C23H24ClN3O3. Mole weight: 425.91. | |
| USP7-USP47 inhibitor | USP7/USP47 inhibitor(compound 14) is a selective USP7 (EC50= 0.42 μM)/USP47 (EC50= 1.0 μM) inhibitor but does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. compound 14 exhibits enhanced potency against HCT-116 cells. treatment of cells with compound 14 resulted in an increase in p53 and an appreciable induction of p21 protein over the DMSO control. Thus, compound 14 penetrated the cells and modulated p53 and p21 as expected for a USP7 inhibitor. Synonyms: MDK25371; MDK25371; MDK25371; USP7-USP47 inhibitor; 2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-. Grades: >98%. CAS No. 1247825-37-1. Molecular formula: C18H11Cl2N3O3S3. Mole weight: 484.4. | |
| Ustekinumab | Ustekinumab is a human monoclonal antibody approved for the treatment of psoriasis and Crohn's disease. Ustekinumab acts via blocking IL-12 and IL-23. Uses: The treatment of psoriasis and crohn's disease. Synonyms: Stelara. CAS No. 815610-63-0. Molecular formula: C6482H10004N1712O2016S46. Mole weight: 145648.1. | |
| Utreloxastat | Utreloxastat is a 15-lipoxygenase inhibitor. Synonyms: 2,5-Cyclohexadiene-1,4-dione, 2,3,5-trimethyl-6-nonyl-. Grades: >98%. CAS No. 1213269-96-5. Molecular formula: C18H28O2. Mole weight: 276.4. | |
| UVI 3003 | UVI 3003 is a selective and high affinity RXR antagonist. UVI 3003 does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer. Synonyms: UVI3003, UVI 3003, UVI-3003; 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid; Compound 10e. Grades: ≥98% by HPLC. CAS No. 847239-17-2. Molecular formula: C28H36O4. Mole weight: 436.58. | |
| Vaborbactam | Vaborbactam is a selective beta-lactamase inhibitor under the development of Rempex Pharmaceuticals. Vaborbactam is a broad-spectrum inhibitor, especially restoring the activity of carbapenems against KPC-producing strains. Combined with a carbapenem, Vaborbactam can be a promising product for the treatment of multidrug resistant Gram-negative bacteria. Phase III clinical trials for the treatment of Bacteraemia, Gram-negative infections, Pneumonia, Pyelonephritis and Urinary tract infections are on-going. Uses: Bacteraemia, gram-negative infections, pneumonia, pyelonephritis and urinary tract infections. Synonyms: RPX-7009; RPX7009; RPX 7009; MP-7009; MP7009; MP 7009; REBO-07; MP-7; VaborbactamREBO-07; MP-7;Meropenem;2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid. Grades: 98%. CAS No. 1360457-46-0. Molecular formula: C12H16BNO5S. Mole weight: 297.14. | |
| Valacyclovir | Valaciclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Uses: Antiviral agents. Synonyms: Valaciclovir; Valtrex. Grades: >98%. CAS No. 124832-26-4. Molecular formula: C13H20N6O4. Mole weight: 324.34. | |
| Valeroyl salicylate | Valeroyl salicylate is a selective and irreversible COX-1 inhibitor with IC50 values of 0.8 and 15 mM for ovine COX-1 and -2, respectively. Synonyms: 2-Valeryloxybenzoic acid; 2-pentanoyloxybenzoic acid. Grades: ≥99%. CAS No. 64206-54-8. Molecular formula: C12H14O4. Mole weight: 222.2. | |
| Valilactone | Valilactone is an esterase and fatty acid synthase (FAS) inhibitor produced by a cultured strain of soil actinomycetes. Synonyms: (-)-Valilactone; [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]heptan-2-yl] (2S)-2-formamido-3-methylbutanoate. Grades: ≥98%. CAS No. 113276-96-3. Molecular formula: C22H39NO5. Mole weight: 397.6. | |
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