BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| YS-121 | YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). Synonyms: YS 121; YS121; 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoic acid. Grades: ≥98%. CAS No. 916482-17-2. Molecular formula: C20H26ClN3O2S. Mole weight: 408. |  |
| YS-201 | YS-201, also known as Diperdipine, is a dihydropyridine-type calcium channel antagonist potentially for the treatment of angina pectoris and hypertension. Synonyms: Diperdipine; YS-201; YS201; YS 201; Epddnp. 3-O-ethyl 5-O-(2-piperidin-1-ylethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; diperdipine; EPDDNP; ethyl-2-(1-piperidino)ethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate. CAS No. 108852-42-2. Molecular formula: C24H31N3O6. Mole weight: 457.52. | |
| YUKA1 | YUKA1 is a cell-permeable inhibitor of lysine demethylase 5A (KDM5A/RBP2/JARID1A) (IC50 value 2.66 μM). YUKA1 inhibits drug resistance and cancer cell growth in HeLa cervical cancer cells and ZR-75-1 breast cancer cells. It increases H3K4me3 level in human cells and selectively inhibits the proliferation of cancer cells associated with KDM5A. Synonyms: YUKA-1; YUKA 1; YUKA1. Grades: 99%. CAS No. 708991-09-7. Molecular formula: C13H16N4O2S. Mole weight: 292.36. | |
| YW1128 | YW1128 is an inhibitor of Wnt/β-catenin signaling. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. Synonyms: 5-Methyl-1-(2-methylphenyl)-N-quinolin-2-yltriazole-4-carboxamide. Grades: ≥98%. CAS No. 2131223-64-6. Molecular formula: C20H17N5O. Mole weight: 343.38. | |
| YW1159 | YW1159 is an inhibitor of Wnt signaling. Synonyms: Compound 3d; 1-(2-Fluorophenyl)-5-methyl-N-quinolin-2-yltriazole-4-carboxamide. Grades: ≥98%. CAS No. 2131223-69-1. Molecular formula: C19H14FN5O. Mole weight: 347.35. | |
| YYA-021 | YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA. Synonyms: YYA-021; YYA 021; YYA021. Grades: >98%. CAS No. 144217-65-2. Molecular formula: C18H27N3O2. Mole weight: 317.43. | |
| Z 944 | Z 944 is a selective T-type Ca2+ channel blocker with IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3. Uses: Calcium channel blockers. Synonyms: 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide; N-((1-(2-(Tert-Butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide. Grades: ≥98% by HPLC. CAS No. 1199236-64-0. Molecular formula: C19H27ClFN3O2. Mole weight: 383.89. | |
| Zacopride hydrochloride | Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Zacopride hydrochloride acts as an antiemetic and anxiolytic following systemic administration in vivo. Uses: Antiemetic and anxiolytic. Synonyms: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 101303-98-4. Molecular formula: C15H20ClN3O2.HCl. Mole weight: 346.26. | |
| Zaltidine | Zaltidine is an effective but hepatotoxic H2-receptor antagonist. It has higher incidence of hepatic damage than with commonly used H2-receptor antagonists. It has the antisecretory action and is used as an effective treatment of duodenal ulcer. Uses: Zaltidine has the antisecretory action and is used as an effective treatment of duodenal ulcer. Synonyms: 2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine;CP-57361;[4-(2-Methyl-1H-imidazol-4-yl)-2-thiazolyl]guanidine;Guanidine,[4-(2-methyl-1H-imidazol-4-yl)-2-thiazolyl]-. Grades: >98%. CAS No. 85604-00-8. Molecular formula: C8H10N6S. Mole weight: 222.27. | |
| Zamifenacin | Zamifenacin is a Muscarinic M3 receptor antagonist originated by Pfizer. pKi value is 8.52 for M3 receptor, 7.93 for M2 receptor, 7.90 for M1 receptor and 7.78 for M4 receptor. It can reduce colonic motor activity in patients with irritable bowel syndrome. But clinical trials for Irritable bowel syndrome was discontinued. Uses: Irritable bowel syndrome. Synonyms: UNII-Y88Q418Y7M;UK 76654; UK76654; UK-76654; Zamifenacin AC1MJ6I5;(3R)-3-benzhydryloxy-1-[2-(1,3-benzodioxol-5-yl)ethyl]piperidine;127308-98-9 (Zamifenacin fumarate). Grades: 95%. CAS No. 127308-82-1. Molecular formula: C27H29NO3. Mole weight: 415.53. | |
| Zamifenacin fumarate | Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist (pKi = 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors, respectively). Zamifenacin fumarate exhibits higher affinity for ileal M3 receptors (pKi = 9.3) than oesophageal and tracheal M3 receptors (pKi = 8.8 and 8.2 respectively). Synonyms: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine fumarate. Grades: ≥99% by HPLC. CAS No. 127308-98-9. Molecular formula: C27H29NO3.C4H4O4. Mole weight: 531.6. | |
| ZAPA sulfate | ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZAPA sulfate is also a GABAA-ρ receptor antagonist. Synonyms: (Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate. CAS No. 371962-01-5. Molecular formula: C4H6N2O2S.H2SO4. Mole weight: 244.24. | |
| Zaprinast | Zaprinast is a cyclic-GMP phosphodiesterase inhibitor with selectivity for PDE6, 5, 11 and 9 (IC50 = 0.15, 0.76, 12.0 and 29.0 μM, respectively). C-GMP acts as a mediator of signal transduction that relaxes vascular smooth muscles and increases blood flow. Therefore zaprinast exhibits vasodilating, relaxant, and diuretic effects. Zaprinast also acts as a putative GPR35 agonist. Synonyms: 2-(2-Propyloxyphenyl)-8-azapurin-6-one; 5-(2-propoxyphenyl)-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one. Grades: ≥99% by HPLC. CAS No. 37762-06-4. Molecular formula: C13H13N5O2. Mole weight: 271.28. | |
| Zatebradine | Zatebradine is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. Its IC50 value is 10 uM of 92% inhibition of the hHCN1. It reduced the activity of oriens-lacunosum moleculare interneurons in wild-type and decreased the frequency of spontaneous inhibitory currents in postsynaptic CA1 pyramidal cells. It is a specific bradycardic agent. Uses: Zatebradine could decrease the heartbeat in a reversible manner. it is a specific bradycardic agent. Synonyms: 2H-3-Benzazepin-2-one, 3-[3-[[2- (3, 4-dimethoxyphenyl) ethyl]methylamino]propyl]-1, 3, 4, 5-tetrahydro-7, 8-dimethoxy-; Zatebradinum; Zatebradina; 3-[3-[2- (3, 4-dimethoxyphenyl) ethyl-methylamino]propyl]-7, 8-dimethoxy-2, 5-dihydro-1H-3-benzazepin-4-one; UL-FS49. Grades: >98%. CAS No. 85175-67-3. Molecular formula: C26H36N2O5. Mole weight: 456.57. | |
| Zatebradine hydrochloride | Zatebradine hydrochloride is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. It is a bradycardic compound that blocks hyperpolarization-activated inward current through cyclic nucleotide-gated cation channels in sinoatrial node cells. It can block voltage-gated outward K+ currents and related neuronal hyperpolarization-activated inward current channels, but exhibits little or no activity for L-type Ca2+ currents. It is also a sinus node inhibitor. It displays negative chronotropic activity in isolated guinea pig atria. It was developed by Boehringer Ingelheim. Uses: Zatebradine hydrochloride could decrease the heartbeat in a reversible manner. it is also a sinus node inhibitor. Synonyms: Zatebradine HCl; Zatebradine Hydrochloride; UL-FS49; UL FS49; ULFS49;;UL-FS-49CL;UL-FS49;3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride;2H-3-Benzazepin-2-one, 3- (3- ( (2- (3, 4-dimethoxyphenyl) ethyl) methylamino) propyl) -1, 3, 4, 5-tetrahydro-7, 8-dimethoxy-, monohydrochloride. Grades: >98 %. CAS No. 91940-87-3. Molecular formula: C26H37ClN2O5. Mole weight: 493.04. | |
| Zatosetron maleate | Zatosetron has been identified as a potent, orally available, long-acting, selective 5HT3 receptor antagonist, which is potentially useful in the treatment of central nervous system disorders such as emesis induced by oncolytic drugs, migraine, dementia, anxiety, schizophrenia, and substance abuse. Synonyms: (Z)-but-2-enedioic acid;5-chloro-2,2-dimethyl-N-[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-3H-1-benzofuran-7-carboxamide; 5-chloro-2,3-dihydro-2,2-dimethyl-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-7-benzofurancarboxamide; LY 277359; LY 277359 maleate; LY-277359; zatosetron; zatosetron maleate. CAS No. 123482-23-5. Molecular formula: C23H29ClN2O6. Mole weight: 464.94. | |
| Zaurategrast | Zaurategrast is an oral α4-integrin inhibitor. It significantly decreased the capacity of lymphocytes to bind vascular adhesion molecule-1 (VCAM-1) and the expression of α4-integrin on VCAM-1-binding cells. Synonyms: CDP323; CDP-323; CDP 323; Zaurategrast. Grades: >98%. CAS No. 455264-31-0. Molecular formula: C26H25BrN4O3. Mole weight: 521.41. | |
| Zavacorilant | Zavacorilant is a glucocorticoid receptor antagonist. Synonyms: zavacorilantum. Grades: >98%. CAS No. 1781245-13-3. Molecular formula: C25H26FN7O3S2. Mole weight: 555.7. | |
| ZB716 | ZB716 is a steroidal and orally bioactive selective estrogen receptor downregulator (SERD) with antiestrogenic activity. In both tamoxifen-naive and tamoxifen-resistant breast cancer cells, ZB716 dose-dependently inhibits cell proliferation and effectively degrades the hormone receptor. Synonyms: ZB716; ZB 716; ZB-716; fulvestrant-3-boronic acid. Grades: 99%. CAS No. 1853279-29-4. Molecular formula: C32H48BF5O4S. Mole weight: 634.59. | |
| Z-Cyclopentyl-AP4 | Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist with higher potency at mGlu4 than mGlu8 (EC50 = 49 and 124 μM, respectively). Z-Cyclopentyl-AP4 selectively inhibits synaptic activity in the lateral perforant pathway (IC50 = 130 and 1859 μM in the lateral and medial perforant pathways, respectively). Synonyms: cis-(±)-1-Amino-3-phosphonocyclopentane carboxylic acid. Grades: ≥98% by HPLC. CAS No. 103439-17-4. Molecular formula: C6H12NO5P. Mole weight: 209.14. | |
| ZCZ 011 | ZCZ 011 is a cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the binding of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) to CB1 and reduces neuropathic pain in the mouse with no psychoactive effects. ZCZ 011 may be beneficial for neuropathic and inflammatory pain treatment. Uses: Anti-inflammatory agent. Synonyms: ZCZ011; ZCZ-011; ZCZ 011. 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole. Grades: 99%. CAS No. 1998197-39-9. Molecular formula: C21H18N2O2S. Mole weight: 362.44. | |
| ZD 2079 | ZD 2079 is a β3-adrenoceptor agonist. ZD 2079 inhibits ob gene expression and circulating leptin levels in lean mice in vivo, and has the potential to treat obesity and type 2 diabetes. Uses: Potential treatment of obesity and type ii diabetes. Synonyms: 4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethoxy]-benzeneacetic acid hydrochloride; Talibegron hydrochloride; Talibegron HCl, Talibegron hydrochloride, D-2079, ICI-D-2079, SCH-417849, ZD-2079, D2079, ICI-D2079, SCH417849, ZD2079. Grades: ≥99% by HPLC. CAS No. 178600-17-4. Molecular formula: C18H21NO4.HCl. Mole weight: 351.83. | |
| ZD-4190 | ZD-4190, a substituted 4-anilinoquinazoline, is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, with broad-spectrum antitumor efficacy. ZD-4190 is one of a series of VEGF RTK inhibitors that may have utility in the treatment of a range of histologically diverse solid tumor types. Synonyms: ZD-4190; ZD 4190; ZD4190. CAS No. 413599-62-9. Molecular formula: C19H16BrFN6O2. Mole weight: 459.27. | |
| ZD 7114 hydrochloride | ZD 7114 hydrochloride is a β3-adrenoceptor agonist. Synonyms: Acetamide, 2-[4-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethoxy]phenoxy]-N-(2-methoxyethyl)-, monohydrochloride, (S)-; ZD 7114 monohydrochloride; ZD7114 hydrochloride; ZD-7114 hydrochloride; (S)-4-[2-Hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamide hydrochloride. Grades: ≥95%. CAS No. 129689-28-7. Molecular formula: C22H30N2O6.HCl. Mole weight: 454.95. | |
| ZD 7155 hydrochloride | ZD 7155 hydrochloride is a potent, selective and competitive antagonist for the angiotensin II type 1 (AT1) receptor. ZD 7155 hydrochloride displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes (IC50 = 3.8 nM). ZD 7155 hydrochloride exhibits a longer acting duration compared to the prototype AT1 antagonist, losartan. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: ZD 7155 hydrochloride; ZD7155 hydrochloride; ZD-7155 hydrochloride; 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride. Grades: ≥98% by HPLC. CAS No. 146709-78-6. Molecular formula: C26H26N6O.HCl. Mole weight: 474.99. | |
| ZD 7288 | ZD 7288 is a reported blocker of the hyperpolarization activated cation current If (HCN channel). ZD 7288 modulates the sino-atrial node function, and slows heart rate. ZD 7288 blocks Ih in central neurons. Uses: Cardiotonic agents. Synonyms: ZD7288; ZD-7288; ZD 7288; 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride; ICI D2788. Grades: ≥99% by HPLC. CAS No. 133059-99-1. Molecular formula: C15H21ClN4. Mole weight: 292.81. | |
| ZD8321 | ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) (Ki= 13±1.7 nM), suppressing adhesion of neutrophils to TNFa-activated endothelial cells. That of cancer cells with high intracellular elastase activity was also suppressed by ZD8321. Synonyms: methyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate; 1-(2-methoxycarbonyl-3-methylbutyryl)-N-(2-methyl-1-(trifluoroacetyl)propyl)pyrrolidine-2-carboxamide; ZD 8321; ZD-8321. CAS No. 182073-77-4. Molecular formula: C18H28F3N3O5. Mole weight: 423.43. | |
| ZD 9379 | ZD 9379 is an antagonist of glycine site on the NMDA receptor, displaying neuroprotective effects. ZD 9379 reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Synonyms: ZD-9379; ZD 9379; ZD9379; 7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione. Grades: ≥98% by HPLC. CAS No. 170142-20-8. Molecular formula: C19H14ClN3O4. Mole weight: 383.79. | |
| Z-DEVD-CMK trifluoroacetate salt | Z-DEVD-CMK is a protease inhibitor.that irreversibly inhibits recombinant caspase-3, cathepsin B, cathepsin L, cathepsin V, cathepsin F, and cathepsin S in enzyme assays. Grades: ≥95%. Molecular formula: C27H35ClN4O12·xCF3COOH. Mole weight: 643.04. | |
| Zenarestat | Zenarestat is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract. It was developed by Fujisawa Pharmaceutical Co Ltd and was terminated in clinic phase 3 trials. Uses: Zenarestat was investigated as a treatment of diabetic neuropathy and cataract. Synonyms: FR 74366; FR74366 FR-74366; CI-1014; FK-366; CI1014; FK366; FK 366; FK-366; Zenarestat;2-[3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxoquinazolin-1-yl]acetic acid;FR74366;3-(2-Fluoro-4-bromobenzyl)-7-chloro-2,4(1H,3H)-dioxoquinazoline-1-acetic acid;3-[(4-Bromo-2-fluorophenyl)methyl]-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid. Grades: 95%. CAS No. 112733-06-9. Molecular formula: C17H11BrClFN2O4. Mole weight: 441.64. | |
| Zetomipzomib | Zetomipzomib is a small-molecule, dual inhibitor of immune proteasome subunit LMP7/LMP2. Synonyms: KZR-616; KZR 616; KZR616. Grades: >98%. CAS No. 1629677-75-3. Molecular formula: C30H42N4O8. Mole weight: 586.68. | |
| (Z)-FeCP-oxindole | (Z)-FeCP-oxindole is a human vascular endothelial cell growth factor receptor 2 (VEGFR-2) inhibitor (IC50 = 220 nM). (Z)-FeCP-oxindole exhibits anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Synonyms: (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one. CAS No. 1137967-28-2. Molecular formula: C19H15FeNO. Mole weight: 329.17. | |
| Zicronapine | Zicronapine, an inden derivative, has been found to be neurotransmitter receptor modulators of sorts of neurotransmitter and was studied against Schizophrenia. Synonyms: Zicronapine; Lu 31-130; Lu31-130; Lu-31-130; Lu 31130; Lu31130; Lu-31130; UNII-QZV11V7G6A; 4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine. Grades: 98%. CAS No. 170381-16-5. Molecular formula: C22H27ClN2. Mole weight: 354.92. | |
| Zifanocycline | Zifanocyclinum is a tetracycline antibiotic. Synonyms: 2-Naphthacenecarboxamide, 9-(3-azabicyclo[3.1.0]hex-3-ylmethyl)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-. Grades: >98%. CAS No. 1420294-56-9. Molecular formula: C29H36N4O7. Mole weight: 552.62. | |
| Z-Ile-Glu(O-t-butyl)-Ala-Leucinal | PSI is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It causes dopaminergic cell death in vitro and prevents activation of NF-κB in response to TNF-α and okadaic acid by inhibiting IκB-α degradation. Uses: Cysteine proteinase inhibitors. Synonyms: Proteasome Inhibitor I; PSI peptide; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester. Grades: ≥ 90 % by HPLC. CAS No. 158442-41-2. Molecular formula: C32H50N4O8. Mole weight: 618.76. | |
| Z-Ile-Leu-aldehyde | Z-Ile-Leu-aldehyde ia a cell-permeable and reversible inhibitor that inhibits γ-secretase and Notch signaling. It induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity in vitro. It has potent anti-MM activity and reduces osteolytic lesions in vivo. Uses: Gamma secretase inhibitors and modulators. Synonyms: Z-IL-CHO; GSI-XII; Z-Ile-Leu-al; Z Ile Leu al; Z IL CHO; Gamma-secretase inhibitor XII; [(1S,2S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester; Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate; N-benzyloxycarbonyl-L-isoleucyl-L-leucinal. Grades: ≥95%. CAS No. 161710-10-7. Molecular formula: C20H30N2O4. Mole weight: 362.46. | |
| Zileuton sodium | Zileuton sodium is an inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes(LTB4, LTC4, LTD4 and LTE4) formation with an IC50 value of 0.5μM. Zileuton sodium has been reported to concentration-dependently inhibit the 5-lipoxygenase activity with an IC50 value of 0.5μM in RBL-1cell lysate. In addition, Zileuton sodium has been found to be a potent inhibitor of LTB formation with an IC50 value of 0.6μM. Furthermore, stimulated with A23187, Zileuton sodium has shown a dose-dependent reduction in LTB4 and 5-HETE generation in rat leukocyte with IC50 values of 0.38μM and 0.31μM, respectively. About 40-fold higher concentrations of Zileuton sodium also reduced the production of PGE2 with a IC50 of 16μM. Synonyms: Zyflo sodium. Grades: >98%. CAS No. 118569-21-4. Molecular formula: C11H11N2NaO2S. Mole weight: 258.27. | |
| Zimelidine dihydrochloride | Zimelidine dihydrochloride is a 5-HT reuptake inhibitor with selectivity over noradrenalin and dopamine uptake (IC50 = 0.33, 8.2 and 12 μM, respectively). Zimelidine modulates nociception and induces hyperglycemia in vivo, and is used as an orally active antidepressant. Synonyms: (2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine dihydrochloride; Zimeldine hydrochloride; 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, hydrochloride (1:2), (2Z)-; 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, dihydrochloride, (2Z)-; 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, dihydrochloride, (Z)-; H 102/09 hydrochloride. Grades: ≥98% by HPLC. CAS No. 60525-15-7. Molecular formula: C16H17BrN2.2HCl. Mole weight: 390.15. | |
| Zinc protoporphyrin IX | Zinc protoporphyrin IX is an endogenous metabolite formed during heme biosynthesis and a heme oxygenase inhibitor. Heme oxygenase is the enzyme producing CO, which is an activator of guanylyl cyclase and shares some chemical and biological properties of NO. Zinc protoporphyrin IX has been shown to inactivates the NOS isoforms nNOS, iNOS, and eNOS(IC50 = 0.8, 4, and 5 μM, respectively). Synonyms: 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid, zinc complex; Zinc protoporphyrin-9; ZnPP; Zinc 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; Zn-Protoporphyrin IX. CAS No. 15442-64-5. Molecular formula: C34H32N4O4Zn. Mole weight: 626.03. | |
| Zinterol | Zinterol is a potent and selective β2-adrenoceptor agonist. Uses: Adrenergic beta-agonists. Synonyms: N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 37000-20-7. Molecular formula: C19H26N2O4S. Mole weight: 378.5. | |
| Zinterol hydrochloride | Zinterol hydrochloride is a potent and selective β2-adrenoceptor agonist (pKB = 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery). Synonyms: Zinterol hydrochloride; Zinterol HCl; N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride; Zinterol HCl; (+-)-Zinterol hydrochloride. Grades: ≥98% by HPLC. CAS No. 38241-28-0. Molecular formula: C19H27ClN2O4S. Mole weight: 414.95. | |
| Ziprasidone | Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmission at dopamine D2 receptors which is significant for the positive symptoms of schizophrenia. Synonyms: 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one 5-(2-(4-(3-benzisothiazolyl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one CP 88059 CP 88059-01 CP-88,059 CP-88,059-01 CP-88,059-1 Geodon ziprasidone ziprasidone. CAS No. 146939-27-7. Molecular formula: C21H21ClN4OS. Mole weight: 412.94. | |
| ZK118182 isopropyl ester | ZK118182 is a prostaglandin (PG) analog that exhibits potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). Synonyms: Propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate. Grades: ≥98%. CAS No. 154927-31-8. Molecular formula: C23H37ClO5. Mole weight: 429. | |
| ZK 164015 | ZK 164015 is a potent estrogen receptor (ER) silent antagonist. ZK 164015 inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM), and inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM). Synonyms: ZK 164015; ZK164015; ZK-164015; 2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol. Grades: ≥99% by HPLC. CAS No. 177583-70-9. Molecular formula: C30H43NO4S. Mole weight: 513.73. | |
| ZK200775 | Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [3H]-AMPA (Ki = 120 nM) and [3H]-CNQX (Ki = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC50 values range from 2.5 to 11 μM). Inhibits currents induced by AMPA, kainate and NMDA with IC50 values of 21 nM, 27 nM, and > 1 μM respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo. Synonyms: Fanapanel; MPQX; ZK-200775; ZK 200775; ZK200775. Grades: >98%. CAS No. 161605-73-8. Molecular formula: C14H15F3N3O6P. Mole weight: 409.25. | |
| ZK200775 hydrate | ZK200775 hydrate(Fanapanel; MPQX) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Synonyms: Fanapanel hydrate; MPQX hydrate; ZK-200775 hydrate; ZK 200775 hydrate; ZK200775 hydrate. Grades: >98%. CAS No. 1255517-78-2. Molecular formula: C14H17F3N3O7P. Mole weight: 427.27. | |
| (+)-ZK 216348 | (+)-ZK 216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis (IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors, respectively). (+)-ZK 216348 exhibits antiinflammatory activity for both systemic and topical application, and shows no negative effects on intestinal epithelial migration or proliferation. Synonyms: ZK216348; ZK 216348; ZK-216348; 4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide. Grades: 99%. CAS No. 669073-68-1. Molecular formula: C24H23F3N2O5. Mole weight: 476.45. | |
| ZK-261991 | ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. The high efficacy, including tumour regression in established tumours, combined with its low toxicity recommends ZK 261991 for development as a drug for the therapy of solid tumours also in combination with other chemotherapeutics. Synonyms: Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2- methyl-2H-indazol-6-yl)-; ZK261991; ZK-261991; ZK 261991; ZK-991; ZK 991. CAS No. 886563-25-3. Molecular formula: C24H25N7O2. Mole weight: 443.5. | |
| ZK 756326 | ZK 756326 is a selective, non-peptide CCR8 agonist. Synonyms: ZK 756326; ZK756326; ZK-756326; 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride. CAS No. 874911-96-3. Molecular formula: C21H28N2O3.2HCl. Mole weight: 429.38. | |
| ZK756326 (dihydrochloride) | ZK756326 is a selective and nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8 (IC50= 1.8 muM). Synonyms: 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride; 2-(2-(4-(3-phenoxybenzyl)piperazin-1-yl)ethoxy)ethanol; ZK 756326; ZK-756326; ZK756326; ZK756326 dihydrochloride. CAS No. 1780259-94-0. Molecular formula: C21H30Cl2N2O3. Mole weight: 429.38. | |
| ZK-90055 hydrochloride | ZK-90055, a β-Adrenoceptor agonist, is a B-2 bronchodilator drug. Synonyms: ZK 90055 hydrochloride; ZK90055 hydrochloride; methyl 4-[2-(tert-butylamino)-1-hydroxyethyl]-7-hydroxy-1H-indole-2-carboxylate;hydrochloride; ZK-90055 (hydrochloride). CAS No. 84638-81-3. Molecular formula: C16H23ClN2O4. Mole weight: 342.82. | |
| ZK 93423 hydrochloride | ZK 93423 hydrochloride is a potent and non-selective benzodiazepine receptor agonist (IC50 = 1 nM) (Ki = 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors, respectively). ZK 93423 hydrochloride acts as an anxiolytic following systemic administration in vivo. Synonyms: ZK 93423 monohydrochloride; ZK93423 hydrochloride; ZK-93423 hydrochloride; 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride; 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 4-(methoxymethyl)-6-(phenylmethoxy)-, ethyl ester, hydrochloride (1:1). Grades: ≥98% by HPLC. CAS No. 1216574-52-5. Molecular formula: C23H22N2O4.HCl. Mole weight: 426.89. | |
| ZK 93426 hydrochloride | ZK 93426 hydrochloride is a potent, selective and competitive benzodiazepine receptor antagonist (IC50 = 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus, respectively). ZK 93426 hydrochloride displays both anxiogenic and anxiolytic effects. Synonyms: ZK 93426 monohydrochloride; ZK93426 hydrochloride; ZK-93426 hydrochloride; 4-Methyl-5-(1-methylethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride; 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 4-methyl-5-(1-methylethoxy)-, ethyl ester, hydrochloride (1:1). Grades: ≥99% by HPLC. CAS No. 1216792-30-1. Molecular formula: C18H20N2O3.HCl. Mole weight: 348.82. | |
| ZL006 | ZL006 is a potent inhibitor of nNOS/PSD-95 interaction. In mice subjected to mCao and reperfusion, pretreatment with Zl006 attenuated the ischemia-induced increase in nnos-PsD-95 complex levels, and in neurons treated with glutamate this drug ameliorated nmDar-dependent nitric oxide synthesis. Synonyms: ZL006; ZL-006; ZL 006; Benzoic acid, 4-[[(3,?5-dichloro-2-hydroxyphenyl)?methyl]?amino]?-2-hydroxy-. CAS No. 1181226-02-7. Molecular formula: C14H11Cl2NO4. Mole weight: 328.15. | |
| ZL0420 | ZL0420 is a potent and selective BRD4 inhibitor with IC50 values of 27 and 32 nM for BRD4 BD1 and BRD4 BD2, respectively. Synonyms: 6-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-1H-quinolin-2-one. CAS No. 2229039-45-4. Molecular formula: C16H16N4O2. Mole weight: 296.32. | |
| ZLD1039 | ZLD1039 potent, highly selective, and orally bioavailable small molecule inhibitor of EZH2, which inhibited the methyltransferase activity of EZH2 with high selectivity across an HMT panel. Treatment of xenograft-bearing mice with ZLD1039 led to tumor growth regression and metastasis inhibition, confirmed the dependency of breast cancer progression on EZH2 activity and the usefulness of ZLD1039 as a promising treatment for breast cancer. Synonyms: ZLD1039; ZLD-1039; ZLD 1039; 3-[Ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-benzamide. Grades: >98%. CAS No. 1826865-46-6. Molecular formula: C36H48N6O3. Mole weight: 612.819. | |
| Z-LEHD-FMK | Z-LEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-9. Synonyms: Caspase-9 Inhibitor; Methyl (4S) -5-[[ (2S) -1-[[ (3S) -5-fluoro-1-methoxy-1, 4-dioxopentan-3-yl]amino]-3- (1H-imidazol-5-yl) -1-oxopropan-2-yl]amino]-4-[[ (2S) -4-methyl-2- (phenylmethoxycarbonylamino) pentanoyl]amino]-5-oxopentanoate; 2, 2, 2-trifluoroacetic acid. CAS No. 524746-03-0. Molecular formula: C34H44F4N6O12. Mole weight: 804.74. | |
| Z-Leu-Leu-Norvalinal | (S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). Uses: Protease inhibitors. Synonyms: benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate. Grades: 95 %. CAS No. 133407-86-0. Molecular formula: C25H39N3O5. Mole weight: 461.59. | |
| ZLJ-6 | ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with IC50 values of 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively. It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective COX inhibitors. Grades: ≥98%. CAS No. 1051931-39-5. Molecular formula: C12H13N3O3S·CH3SO3H. Mole weight: 375.4. | |
| ZLN024 | ZLN024 is a novel AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2-2.5 fold. It activated AMPK in L6 myotubes and stimulated glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. It also activated AMPK in primary hepatocytes, decreased fatty acid synthesis and glucose output. Synonyms: ZLN024; ZLN 024; ZLN-024. Grades: >98%. CAS No. 723249-01-2. Molecular formula: C13H13BrN2OS. Mole weight: 325.22. | |
| ZLN024 hydrochloride | ZLN024 Hydrochloride acts as an allosteric AMP-activated protein kinase activator, stimulating glucose uptake and fatty acid oxidation. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively. Synonyms: ZLN024 (hydrochloride). Grades: 98%. CAS No. 1883548-91-1. Molecular formula: C13H14BrClN2OS. Mole weight: 361.69. | |
| ZM 226600 | ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM) devoid of antiandrogen properties. Synonyms: ZM 226600; ZM226600; ZM-226600; N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide. CAS No. 147695-92-9. Molecular formula: C16H14F3NO4S. Mole weight: 373.35. | |
| ZM-230487 | ZM-230487, a quinolin derivative, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene D4 receptor antagonist. It was once studied in anti-inflammatories and osteoporosis therapies. Synonyms: ICI-230487; ICI230487; ICI 230487; ZM 230487; ZM-230487; ZM230487; 1-Ethyl-6-((3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy)methyl)-2-quinolone; CHEMBL459236. Grades: 98%. CAS No. 155944-23-3. Molecular formula: C24H26FNO4. Mole weight: 411.47. | |
| ZM 241385 | ZM 241385 is a potent, highly selective A2A antagonist. Synonyms: ZM241385; ZM-241385; ZM 241385. 4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol. CAS No. 139180-30-6. Molecular formula: C16H15N7O2. Mole weight: 337.34. | |
| ZM 260384 | ZM 260384, a benzoxazine derivative, has been found to be a potassium channel agonist that was once studied against hypertension and thrombus. Synonyms: ZM 260384; ZM-260384; ZM260384; AC1L53UP; SCHEMBL6369154; DTXSID90167090; HE092130; 2,2-bis(difluoromethyl)-6-nitro-4-(1-oxido-2H-pyridin-6-yl)-3H-1,4-benzoxazine. Grades: 98%. CAS No. 161229-62-5. Molecular formula: C15H11F4N3O4. Mole weight: 373.26. | |
| ZM306416 | ZM306416 is a vascular endothelial growth factor receptor (VEGFR) antagonist. Synonyms: ZM306416; ZM 306416; ZM-306416. Grades: 0.98. CAS No. 690206-97-4. Molecular formula: C16H13ClFN3O2. Mole weight: 333.74. | |
| ZM 306416 hydrochloride | ZM 306416 hydrochloride is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase with > 3-fold selectivity over FGFR-1. ZM 306416 hydrochloride inhibits activity of KDR and FLT VEGF receptors (IC50 = 100 nM and 2 μM, respectively). Synonyms: ZM 306416 hydrochloride; ZM306416 hydrochloride; ZM-306416 hydrochloride; 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride. Grades: ≥99% by HPLC. CAS No. 196603-47-1. Molecular formula: C16H13N3O2FCl.HCl. Mole weight: 370.21. | |
| ZM323881 | ZM323881 inhibits VEGF-A, EGF and bFEF induced HUVEC cell proliferation with IC50 of 8 nM, 1.9 μM and 1.6 μM, respectively. ZM323881 (10 nM) abolishes VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in male leopard. ZM323881 (10 nM) blocks the increase in intensity of the VEGF-R2 band in the lung of male leopard frogs. M323881 (1 μM) blocks activation of extracellular regulated-kinase, p38, Akt, and endothelial nitric oxide synthetase (eNOS) by VEGF, but did not inhibit p38 activation by the VEGFR-1-specific ligand, placental growth factor (PIGF) in human aortic endothelial cells (HAECs). ZM323881 (1 μM) also perturbes VEGF-induced membrane extension, cell migration, and tube formation by HAECs. ZM323881 (1 μM) reverses VEGF-stimulated phosphorylation of CrkII and its Src homology 2 (SH2)-binding protein p130Cas, which are known to play a pivotal role in regulating endothelial cell migration. ZM323881 (10 nM) completely blocks VEGF-induced VEGF promoter activity in SCC-9 cells. ZM323881 (10 nM) blocks VEGF stimulated Hif-1α protein accumulation in SCC-9 cells. ZM323881 (10 nM) blocks VEGF-induced Rac1 activation at 30 min in HUVECs. ZM323881 (10 nM) prevents Vav2 tyrosine phosphorylation in response to VEGF in HUVECs. Synonyms: ZM 323881; ZM-323881. Grades: >98%. CAS No. 193001-14-8. Molecular formula: C22H18FN3O2. Mole weight: 375.4. | |
| ZM323881 hydrochloride | Potent and selective inhibitor of VEGFR2 (IC50: 2 nM for VEGFR2 vs >50 mM for VEGFR1 respectively). Synonyms: ZM-323881 hydrochloride; ZM 323881 hydrochloride. Grades: >98%. CAS No. 193000-39-4. Molecular formula: C22H19ClFN3O2. Mole weight: 411.86. | |
| ZM336372 | ZM336372 is a Raf-1 activating agent, has been shown to cause growth inhibition and suppression of hormone secretion in a neuroendocrine cell line. ZM336372 causes growth inhibition, suppression of hormone secretion, and up-regulation of cell cycle inhibitors in a human hepatocellular carcinoma cell line, similar to that previously seen in NETs. Synonyms: ZM-336372; ZM 336372. Grades: 0.98. CAS No. 208260-29-1. Molecular formula: C23H23N3O3. Mole weight: 389.45. | |
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