BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| TCS 2002 | TCS 2002 is a potent and cell-permeable inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration of TCS 2002 inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Synonyms: TCS-2002; TCS 2002; TCS2002; 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole. Grades: ≥99% by HPLC. CAS No. 1005201-24-0. Molecular formula: C18H14N2O3S. Mole weight: 338.38. |  |
| TCS 21311 | TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM) with selectivity for JAK3 over JAK1, JAK2 and TYK2 (IC50 = 1017, 2550 and 8055 nM, respectively). It also inhibits GSK-3β, PKCα and PKCθ (IC50 = 3, 13 and 68 nM, respectively). Synonyms: NIBR3049; NIBR-3049; NIBR 3049; TCS-21311; TCS 21311; TCS21311; 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grades: ≥98% by HPLC. CAS No. 1260181-14-3. Molecular formula: C27H25F3N4O4. Mole weight: 526.51. | |
| TCS 2312 | TCS 2312 is a potent checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). TCS 2312 potentiates the cell killing activity of Gemcitabine in breast and prostate cancer cell lines, and exhibits antiproliferative effects in vitro. Synonyms: TCS 2312; TCS2312; TCS-2312; 4'-[5-[[3-[ (Cyclopropylamino) methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1, 1'-biphenyl]-2, 4-diol. Grades: ≥97% by HPLC. CAS No. 838823-31-7. Molecular formula: C25H24N4O2. Mole weight: 412.48. | |
| TCS 2314 | TCS 2314 is an integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM) that inhibits the activation of inflammatory cells. Synonyms: TCS2314, TCS 2314, TCS-2314; 1-[[ (3S) -4-[2-[4-[[[ (2-Methylphenyl) amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid. Grades: ≥99% by HPLC. CAS No. 317353-73-4. Molecular formula: C28H34N4O6. Mole weight: 522.59. | |
| TCS-359 | TCS-359 is a potent inhibitor of FLT3 with IC50 of 42 nM. Synonyms: TCS359, TCS 359, TCS-359. Grades: 0.98. CAS No. 301305-73-7. Molecular formula: C18H20N2O4S. Mole weight: 360.428. | |
| TCS 46b | TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 = 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes, respectively). TCS 46b potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Synonyms: 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-; 1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-2H-benzimidazol-2-one; 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propynyl]-; 5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one; TCS 46B. Grades: ≥98% by HPLC. CAS No. 302799-86-6. Molecular formula: C22H23N3O. Mole weight: 345.44. | |
| TCS 5861528 | TCS 5861528 is a selective TRPA1 blocker with IC50 values are 14.3 and 18.7μM respectively), attenuates diabetes mellitus hypersensitivity and displays antinociceptive properties. Uses: A potent and selective trpa1 (trp ankyrin 1) channel antagonist. Synonyms: Chembridge-5861528;TCS5861528, TCS-5861528, TCS 5861528, N-(4-butan-2-ylphenyl)-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide. Grades: >98 %. CAS No. 332117-28-9. Molecular formula: C19H23N5O3. Mole weight: 369.42. | |
| TC-S 7005 | TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM) with selectivity over PLK3 and PLK1 (IC50 = 24 and 214 nM, respectively). TC-S 7005 has been shown to induce mitotic arrest and cell death in HCT 116 colorectal cells. Synonyms: TC-S 7005; TC S 7005; TCS 7005; TCS-7005; TCS7005; 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine; 2-amino-isoxazolopyridine. Grades: ≥98% by HPLC. CAS No. 1082739-92-1. Molecular formula: C21H17N3O3. Mole weight: 359.38. | |
| TC-S 7009 | TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM) that displays >60-fold selectivity for HIF-2α over HIF-1&alpha. TC-S 7009 binds to the HIF-2α PAS-B domain to disrupt HIF-2α-ARNT heterodimerization, decrease HIF-2α DNA-binding and suppress expression of HIF-2α target genes in vitro. Synonyms: TCS 7009; TC S 7009; TC-S 7009; N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine. Grades: ≥99% by HPLC. CAS No. 1422955-31-4. Molecular formula: C12H6ClFN4O3. Mole weight: 308.65. | |
| TCS HDAC6 20b | TCS HDAC6 20b is a histone deacetylase 6 (HDAC6) inhibitor. TCS HDAC6 20b inhibits HCT116 growth at a concentration of 5 μM in combination with taxol. It also inhibits growth of MCF-7 cells stimulated by estrogen. Synonyms: NCT-14b; NCT 14b; NCT14b; 2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester. Grades: ≥98% by HPLC. CAS No. 956154-63-5. Molecular formula: C26H44N2O4S. Mole weight: 480.7. | |
| TCS OX2 29 | TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM) displaying >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Orexin is a neuropeptide produced in the lateral hypothalamus (LH) regulates arousal, pain and appetite. Synonyms: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 372523-75-6. Molecular formula: C23H31N3O3.HCl. Mole weight: 433.97. | |
| TCS-OX2-29 HCl | TCS-OX2-29, also known as TCSOX229, is a selective OX2 receptor antagonist (IC50 = 40 nM, pKi=7.5) with >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively) and a range of receptors, ion channels and transporters. Synonyms: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride; TCSOX229, TCSOX-229, TCSOX 229, TCS-OX229; TCS OX2 29; TCS OX229; TCS-OX2-29; TCS OX-229; TCS OX2 29 HCl; TCS OX2 29 hydrochloride. CAS No. 1610882-30-8. Molecular formula: C23H32ClN3O3. Mole weight: 433.97. | |
| Tebanicline hydrochloride | Tebanicline hydrochloride is the hydrochloride salt of Tebanicline (ABT-594) which is a neuronal nicotinic acetyl-choline receptor agonist and has been described as a breakthrough inanalgesia. Synonyms: 5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine;hydrochloride; ebanicline; ABT-594; ABT 594; ABT594; Ebanicline. CAS No. 203564-54-9. Molecular formula: C9H12Cl2N2O. Mole weight: 235.11. | |
| Tedatioxetine | Tedatioxetine is an antidepressant agent. It acts as a triple reuptake inhibitor and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. It was discovered by scientists at Lundbeck and then developed by Lundbeck and Takeda together. It was in phase II clinical trials for major depressive disorder, but has been terminated. Uses: Tedatioxetine is used for major depressive disorder. Synonyms: 4-[2- (4-Methylphenyl) sulfanylphenyl]piperidine; Lu AA24530; Lu AA-24530;4-(2-(P-tolylthio)phenyl)piperidine. Grades: 98%. CAS No. 508233-95-2. Molecular formula: C18H21NS. Mole weight: 283.43. | |
| Tegobuvir | Tegobuvir is a non-nucleoside nonstructural protein (NS)5B polymerase inhibitor. Synonyms: GS-9190; GS 9190; GS9190; GS-333126; GS 333126; GS333126; Tegobuvir. Grades: >98%. CAS No. 1000787-75-6. Molecular formula: C25H14F7N5. Mole weight: 517.4. | |
| Teijin compound 1 | Teijin compound 1 is a potent CCR2b antagonist. Synonyms: (S)-N-(2-((1-(4-chlorobenzyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide hydrochloride. CAS No. 1313730-14-1. Molecular formula: C21H21ClF3N3O2.HCl. Mole weight: 476.32. | |
| Telapristone | Telapristone, the active metabolite of telapristone acetate (also known as CDB-4124), is a selective progesterone antagonist developed for the long-term treatment of symptoms associated with endometriosis and uterine fibroids. Synonyms: (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(2-methoxyacetyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; Telapristone; metabolite of telapristone acetate (CDB-4124); 198414-31-2 (Telapristone acetate). Grades: >98%. CAS No. 198414-30-1. Molecular formula: C29H37NO4. Mole weight: 463.618. | |
| Telapristone acetate | Telapristone acetate, also known as CDB-4124, acts as an investigational selective progesterone receptor modulator (SPRM) tested for treatment of progesterone sensitive myomata. Synonyms: CDB4124; CDB-4124; CDB 4124; [(8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-(2-methoxyacetyl)-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; 198414-30-1 (Telapristone); CDB4124; CDB-4124; CDB 4124; Telapristone acetate; brand name : Proellex Progenta. Grades: >98%. CAS No. 198414-31-2. Molecular formula: C31H39NO5. Mole weight: 505.64. | |
| Telatinib | Telatinib is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. Synonyms: BAY 57-9352; BAY579352; BAY-57-9352. Grades: >98%. CAS No. 332012-40-5. Molecular formula: C20H16ClN5O3. Mole weight: 409.83. | |
| Telenzepine dihydrochloride | Telenzepine dihydrochloride is a selective and high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Telenzepine was demonstrated ability to inhibit gastric acid secretion. Synonyms: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride; Telenzepine hydrochloride; SR-01000075349. CAS No. 147416-96-4. Molecular formula: C19H22N4O2S.2HCl. Mole weight: 443.39. | |
| Telotristat ethyl | Telotristat ethyl, also known as LX 1032 or LX 1606, a prodrug of telotristat, is a tryptophan hydroxylase inhibitor, developed for the treatment of carcinoid syndrome. Telotristat etiprate has activity in controlling diarrhea associated with carcinoid syndrome. Synonyms: ethyl (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate; LX 1032; LX-1032; LX1032; LX 1606; LX1606; LX-1606; Telotristat ethyl. CAS No. 1033805-22-9. Molecular formula: C27H26ClF3N6O3. Mole weight: 574.98. | |
| Temafloxacin | Temafloxacin is a fluoroquinolone antibiotic effective against gram-positive and gram-negative bacteria. It potently inhibits DNA topoisomerase. Synonyms: A-62254; 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid. Grades: ≥95%. CAS No. 108319-06-8. Molecular formula: C21H18F3N3O3. Mole weight: 417.4. | |
| Temefos | Temefos or temephos is an an insecticide used to to treat water infested in aquatic situations and on domestic pets. Uses: An organophosphate larvicide used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Synonyms: Temephos; [4- (4-dimethoxyphosphinothioyloxyphenyl) sulfanylphenoxy]-dimethoxy-sulfanylidene-$l^{5}-phosphane. Grades: ≥98.0%. CAS No. 3383-96-8. Molecular formula: C16H20O6P2S3. Mole weight: 466.47. | |
| Tenidap | Tenidap is one of the nonsteroidal antiinflammatory drugs. It is a COX1/2 and 5-lipoxygenase inhibitor. Tenidap preferentially inhibits COX-1 and IC50 value is 30 Nm. It has less inhibitory activity towards COX-2 and 5-lipoxygenase with IC50 values is 1.2μM for COX-2 and and > 30μM for 5-lipoxygenase. It was developed by Pfizer for treatment of rheumatoid arthritis. Because of the liver and kidney toxicity, the development was discontinued. In 1998, Tenidap for HIV infections treatment was also discontinued. Uses: Rheumatoid arthritis. Synonyms: TENIDAP;AKOS 91367; AKOS91367; AKOS-91367; 5-Chloro-2,3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide;CP66248,CP-66248-2. Grades: 96%. CAS No. 120210-48-2. Molecular formula: C14H9ClN2O3S. Mole weight: 320.75. | |
| Tenofovir exalidex | Tenofovir exalidex, also known as HDP-Tenofovir and CMX-157, is a highly potent prodrug of the antiviral tenofovir, appeared safe and well-tolerated in patients with hepatitis B, according to a presentation at The Liver Meeting 2017. Tenofovir exalidex results in decreased circulating levels, lowering systemic exposure and thereby reducing the potential for renal and bone side effects. Uses: Anti-hiv agents. Synonyms: 3-(hexadecyloxy)propyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate; Tenofovir exalidex; HDP-Tenofovir; Tenofovir; CMX-157; CMX157; CMX 157. Grades: ≥98% (HPLC). CAS No. 911208-73-6. Molecular formula: C28H52N5O5P. Mole weight: 569.72. | |
| Tenofovir hydrate | Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. Uses: Anti-hiv agents. Synonyms: Viread hydrate; GS 1278 hydrate; GS1278 hydrate; GS-1278 hydrate; PMPA hydrate; TDF hydrate. Grades: >98%. CAS No. 206184-49-8. Molecular formula: C9H16N5O5P. Mole weight: 305.23. | |
| Tenofovir maleate | Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT. Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. Synonyms: Viread maleate; GS 1278 maleate; GS1278 maleate; GS-1278 maleate; PMPA maleate; TDF maleate. Grades: >98%. CAS No. 1236287-04-9. Molecular formula: C13H18N5O8P. Mole weight: 403.28. | |
| Tenovin-1 | Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 μM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure that significantly decreases the growth of BL2 Burkitt's lymphoma and ARN8 melanoma cells. Synonyms: Tenovin-1; Tenovin 1; Tenovin1. CAS No. 380315-80-0. Molecular formula: C20H23N3O2S. Mole weight: 369.48052. | |
| Tenovin-3 | Tenovin-3 is a p53 transcription activator that is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM. Synonyms: Tenovin-3; Tenovin 3; Tenovin3. CAS No. 1011301-27-1. Molecular formula: C18H21N3OS. Mole weight: 327.446. | |
| Tenovin-6 | Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Synonyms: Tenovin-6; Tenovin 6; Tenovin6. CAS No. 1011557-82-6. Molecular formula: C25H34N4O2S. Mole weight: 454.63. | |
| Tenovin 6 Hydrochloride | Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50=10 μM) inhibitor as well as p53 activator. Synonyms: Tenovin 6 Hydrochloride; Tenovin6 Hydrochloride; Tenovin-6 Hydrochloride. Grades: >98%. CAS No. 1011301-29-3. Molecular formula: C25H35ClN4O2S. Mole weight: 491.09. | |
| Tenoxicam | Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID).Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM. Synonyms: BRN-0572193; BRN0572193; BRN 0572193; Tenoxicam; Liman; Octiveran. Grades: >98%. CAS No. 59804-37-4. Molecular formula: C13H11N3O4S2. Mole weight: 337.37832. | |
| Tepoxalin | Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase and may be used to treat asthma and osteoarthritis (OA). Synonyms: ORF 20485; Orf-20485; Tepoxalina; Tepoxaline; RWJ 20485. Grades: 98%. CAS No. 103475-41-8. Molecular formula: C20H20ClN3O3. Mole weight: 385.84. | |
| Terazosin | Terazosin, works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls, is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). Uses: A selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (bph). Synonyms: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone. Grades: ≥98%. CAS No. 63590-64-7. Molecular formula: C19H25N5O4. Mole weight: 387.44. | |
| Tertatolol | Tertatolol, a benzothiopyran derivative, is a potent dual antagonist of beta-adrenoceptor and 5-HT receptor, with antihypertensive effect. Synonyms: 2-Propanol, 1-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]-3-[(1,1-dimethylethyl)amino]-; 1-[(3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol; (±)-Tertatolol; dl-Tertatolol; Racemic Tertatolol; rac Tertatolol. Grades: ≥95%. CAS No. 83688-84-0. Molecular formula: C16H25NO2S. Mole weight: 295.44. | |
| tert-Butyl 2-[(4R,6S)-2,2-Dimethyl-6-[(1-phenyl-1H-terazol-5-ylsulfonyl)methyl]-1,3-dioxan-4-yl]acetate | A heterocyclic-substituted dihydroxyheptenoic acid as an HMG-CoA reductase inhibitor. Synonyms: 2,4,6-Trideoxy-3,5-O-(1-methylethylidene)-6-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-D-erythro-hexanoic Acid 1,1-Dimethylethyl Ester. Grades: 97%. CAS No. 380460-37-7. Molecular formula: C20H28N4O6S. Mole weight: 452.52. | |
| Tertiapin LQ | Tertiapin LQ is a Kir1.1 channel blocker with >250-fold selectivity for Kir1.1 (Kd = 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4, respectively). Tertiapin LQ is a derivative of tertiapin-Q. Molecular formula: C106H179N33O24S4. Mole weight: 2428.03. | |
| Terutroban | Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 induced increase pressure in the bronchi. Synonyms: Terutroban; S 18886; S-18886; S18886; 3-[(6R)-6-[(4-chlorophenyl)sulfonylamino]-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoic acid3-((6-amino-(4-chlorobenzenesulfonyl)-2-methyl-5,6,7,8-tetrahydronapht)-1-yl)propionic acid3-((6R)-6-(((4-chlorophenyl)sulfonyl)amino)-2-methyl-5,6,7,8 te. CAS No. 165538-40-9. Molecular formula: C20H22ClNO4S. Mole weight: 407.91. | |
| Tesaglitazar | Tesaglitazar is a dual-acting agonist of PPARα/γ (IC50 = 0.35 and 3.8 μM for PPARγ and PPARα, respectively). It reduces insulin resistance in obese Zucker rats that has the potential for the treatment of type 2 diabetes. Tesaglitazar also prevents atherosclerosis progression in E3L.CETP transgenic mice. Synonyms: (S) -2-Ethoxy-3-[4-[2- (4-methanesulfonyloxyphenyl) ethoxy]phenyl]propanoic acid; Tesaglitazar; AR-H-039242XX; AZ-242; AZ242; AZ 242; ARH-039242XX; Galida. Grades: ≥98% by HPLC. CAS No. 251565-85-2. Molecular formula: C20H24O7S. Mole weight: 408.47. | |
| Tetraethylammonium bromide | Tetraethylammonium bromide is a selective potassium channel blocker. Synonyms: TEAB; TEA bromide. CAS No. 71-91-0. Molecular formula: C8H20BrN. Mole weight: 210.16. | |
| Tetrahydromagnolol | Tetrahydromagnolol is a major metabolite of magnolol, a natural compound isolated from the bark of the Houpu magnolia. It acts as a peripheral CB2 receptor agonist with an improved potency. It also behaves as an antagonist at GPR55. Synonyms: Magnolignan; 2-(2-hydroxy-5-propylphenyl)-4-propylphenol. Grades: ≥98%. CAS No. 20601-85-8. Molecular formula: C18H22O2. Mole weight: 270.4. | |
| Tetrahydrozoline Hydrochloride | Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity. Grades: >98%. CAS No. 522-48-5. Molecular formula: C13H16N2.HCl. Mole weight: 236.74. | |
| Tetramisole Hydrochloride | Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic. Grades: >98%. CAS No. 5086-74-8. Molecular formula: C11H12N2S.HCl. Mole weight: 240.75. | |
| Tetrindole mesylate | Tetrindole mesylate is a selective monoamine oxidase A (MAO-A) inhibitor identified as an antidepressant drug candidate. Uses: Potential antidepressant. Synonyms: 1H-Pyrazino[3,2,1-jk]carbazole, 8-cyclohexyl-2,3,3a,4,5,6-hexahydro-, methanesulfonate (1:1); 2,3,3a,4,5,6-Hexahydro-8-cyclohexyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate; Tetrindole Methanesulfonate; 8-Cyclohexyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole mesylate; 1H-Pyrazino[3,2,1-jk]carbazole, 8-cyclohexyl-2,3,3a,4,5,6-hexahydro-, monomethanesulfonate. Grades: ≥99% by HPLC. CAS No. 170964-68-8. Molecular formula: C20H26N2.CH3SO3H. Mole weight: 390.54. | |
| Tetrodotoxin, citrate (1:1) (salt) | Tetrodotoxin, citrate (1:1) (salt), also called as TTX citrate, is the citrate salt of tetrodotoxin. Tetrodotoxin is a neurotoxin that reversibly and selectively blocks sodium channel. Synonyms: TETRODOTOXIN;TETRODOTOXIN CITRATE;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE; citratodetetrodotoxina; tetrodotoxin, citrate(1:1)(salt); Octahydro-12-(hydroxymethyl)-2-imino-5, 9:7. Grades: 95%. CAS No. 18660-81-6. Molecular formula: C17H25N3O15. Mole weight: 511.39. | |
| Tetryzoline | Tetryzoline is an alpha receptor agonist used in some over-the-counter eye drops and nasal sprays. Uses: Ophthalmic solutions; sympathomimetics; nasal decongestants. Synonyms: Tetrahydrozoline; Tetryzolin; Tetryzolinum; 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole. CAS No. 84-22-0. Molecular formula: C13H16N2. Mole weight: 200.28. | |
| Texasin | Texasin is a selective human leukocyte 5-lipoxygenase (5-LOX) inhibitor. Synonyms: 6,7-Dihydroxy-4'-Methoxyisoflavone; 6,7-Dihydroxy-3-(4-Methoxyphenyl)-4-Benzopyrone. Grades: 95%. CAS No. 897-46-1. Molecular formula: C16H12O5. Mole weight: 284.26. | |
| TFAP | TFAP is a selective COX-1 inhibitor displaying analgesic properties. Synonyms: COX-1 Inhibitor IV; N-(5-aminopyridin-2-yl)-4-(trifluoromethyl)benzamide. CAS No. 1011244-68-0. Molecular formula: C13H10F3N3O. Mole weight: 281.23. | |
| TG 100572 | TG 100572 is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases. Synonyms: TG 100572; TG100572; TG-10057. Grades: >98%. CAS No. 867334-05-2. Molecular formula: C26H26ClN5O2. Mole weight: 475.97. | |
| TG 100572 Hydrochloride | TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse. Synonyms: TG 100572 Hydrochloride; TG100572 Hydrochloride; TG-100572 Hydrochloride. Grades: >98%. CAS No. 867331-64-4. Molecular formula: C26H27Cl2N5O2. Mole weight: 512.43. | |
| TG 100801 | TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases. It is currently in a clinical trial as a first in class, VEGFr2 targeting, topically applied compound for the treatment of AMD. It is a new drug that inhibits ocular angiogenesis, vascular leak, and inflammation in laboratory studies. Synonyms: TG 100801; TG100801; TG-100801. Grades: >98%. CAS No. 867331-82-6. Molecular formula: C33H30ClN5O3. Mole weight: 580.08. | |
| TG 100801 Hydrochloride | TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fy. Synonyms: TG 100801 Hydrochloride; TG100801 Hydrochloride; TG-100801 Hydrochloride. Grades: >98%. CAS No. 1018069-81-2. Molecular formula: C33H31Cl2N5O3. Mole weight: 616.54. | |
| TG6-10-1 | TG6-10-1, a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, has been shown antagonist activity at human EP2 receptor expressed in rat C6 cells. It shows low-nanomolar antagonist activity against EP2 (>300-fold selectivity ov. Synonyms: (E)-N-[2-[2-(trifluoromethyl)indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamideTG6-10-1; TG 6-10-1; TG-6-10-1; TP6101; TP-6101; TP 6101. CHEMBL32642041415716-58-3C23H23F3N2O4BDBM50016950AKOS0274399 55CS-4637; AK-499428; HY-16978; CS 4637; AK 499428; HY 16978; CS4637; AK499428; HY16978(E)-N-(2-(2-(Trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trime. CAS No. 1415716-58-3. Molecular formula: C23H23F3N2O4. Mole weight: 448.43. | |
| TG6-129 | TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with IC50 value of 1.6 μM. It reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. Synonyms: SID 17503974; (E)-N-[[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]carbamothioyl]-3-(4-fluorophenyl)prop-2-enamide. Grades: ≥98%. CAS No. 1164464-14-5. Molecular formula: C20H18FN5O3S3. Mole weight: 491.6. | |
| TGN 020 | TGN 020 is a derivative of thiadiazole and an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). TGN 020 increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice. Synonyms: TGN-020; TGN 020; TGN020; N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide; 2-(Nicotinamido)-1,3,4-thiadiazole. Grades: ≥99% by HPLC. CAS No. 51987-99-6. Molecular formula: C8H6N4OS. Mole weight: 206.22. | |
| TGR-1202 hydrochloride | TGR-1202 hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202, also known as RP5264, is a highly specific, orally available, PI3Kdelta inhibitor which is approximately 1000 -fold selective over alpha isoform, >30-50 fold over beta isoform and >15-. Synonyms: RP5264 hydrochloride; TGR1202 hydrochloride; RP 5264 hydrochloride; TGR 1202 hydrochloride; RP-5264 hydrochloride; TGR-1202 hydrochloride. CAS No. 1532533-78-0. Molecular formula: C31H25ClF3N5O3. Mole weight: 608.01. | |
| TH 1020 | TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). TH 1020 competes with flagellin for TLR5 binding to inhibit the downstream TNF-α signaling pathways. Synonyms: TH1020; TH-1020; TH 1020; 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine. Grades: ≥98% by HPLC. CAS No. 1841460-82-9. Molecular formula: C23H15N7S2. Mole weight: 453.54. | |
| TH 1834 | TH 1834 is a Tip60 histone acetyltransferase inhibitor. TH 1834 causes apoptosis and increases unrepaired DNA damage (following ionizing radiation treatment) in breast cancer cells, yet not control cell lines or affect the activity of related HAT MOF. Synonyms: TH 1834; TH1834; TH-1834; 2-[5- (4-{[ (2-phenylethyl) ({4-[4- (pyrrolidin-1-ylmethyl) phenoxy]butyl}) amino]methyl}phenyl) -2H-1, 2, 3, 4-tetrazol-2-yl]acetic acid. Grades: 99%. Molecular formula: C33H40N6O3.2HCl. Mole weight: 641.63. | |
| TH34 | TH34 is a HDAC inhibitor with selectivity for HDAC6, 8 and 10. It has been shown to induce DNA damage and G2/M phase cell cycle arrest in neuroblastoma cell lines as well as primary neuroblastoma cells, suggesting that it is identified as a potential antineoplastic agent. Synonyms: 3-(benzylamino)-N-hydroxy-4-methylbenzamide. CAS No. 2196203-96-8. Molecular formula: C15H16N2O2. Mole weight: 256.30. | |
| THDOC | THDOC is a positive allosteric modulator of GABAA receptors. Uses: Anesthetics. Synonyms: Tetrahydrodeoxycorticosterone; (3α,5α)-3,21-Dihydroxypregnan-20-one; 3alpha,21-Dihydroxy-5alpha-pregnan-20-one; 21-Hydroxyallopregnanolone; Allotetrahydrodeoxycorticosterone. Grades: ≥95% by HPLC. CAS No. 567-02-2. Molecular formula: C21H34O3. Mole weight: 334.49. | |
| Theliatinib | Theliatinib is a highly potent, ATP-competitive EGFR inhibitor with 50-fold greater selectivity for EGFR compared to 72 other kinases. It exhibits anti-tumor activity in multiple xerographs such as A-431, Bcap-37 and Fadu. Synonyms: HMPL-309; (3aR,6aR)-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxamide. CAS No. 1353644-70-8. Molecular formula: C25H26N6O2. Mole weight: 442.51. | |
| Theodrenaline | Theodrenaline, also known as noradrenalinoethyltheophylline, is a cardiac stimulant with anti-hypotensive property together with cafedrine. Synonyms: 7-[2-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]ethyl]-1,3-dimethylpurine-2,6-dione; noradrenaline theophylline; noradrenaline theophylline, (R)-isomer; noradrenaline theophylline, hydrochloride; noradrenaline theophylline, monohydrochloride, (R)-isomer; theodrenaline; theodrenaline hydrochloride; theodrenaline hydrochloride, (R)-isomer; theodrenaline, (R)-isomer. CAS No. 13460-98-5. Molecular formula: C17H21N5O5. Mole weight: 375.38. | |
| Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride | An inhibitor of CHK1 and CHK2. Synonyms: Thieno[2,?3-d]?pyridazine-7-carboxamide, 2-(3-fluorophenyl)?-4-[(3S)?-3-piperidinylamino]?-, hydrochloride (1:1). CAS No. 1278405-51-8. Molecular formula: C18H19ClFN5OS. Mole weight: 407.89. | |
| thiethylperazine | Thiethylperazine is a dopamine receptor antagonist It is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects. It is useful in the treatment of nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. Uses: Antiemetic. Synonyms: 2-ethylthio-10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine; thiethylperazine; Tietylperazine; Ethylthioperazine.; 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; 2-(Ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine; Tor. Grades: 98%. CAS No. 1420-55-9. Molecular formula: C22H29N3S2. Mole weight: 399.62. | |
| Thifluzamide | Thifluzamide, a highly potent fungicide, could be commonly used in potatoes and rice against basidiomycete fungi. Uses: Thifluzamide is a highly potent fungicide that could be commonly used in potatoes and rice against basidiomycete fungi. Synonyms: Greatam;Thifluzamide. Grades: 95%. CAS No. 130000-40-7. Molecular formula: C13H6Br2F6N2O2S. Mole weight: 528.06. | |
| Thioetheramide-PC | Thioetheramide-PC is a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). It binds to the catalytic site and the activator site of sPLA2. At low concentrations, thioetheramide-PC may activate phospholipase activity rather than inhibiting it. Synonyms: 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine; 2-[[(2S)-2-(hexadecanoylamino)-3-hexadecylsulfanylpropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium. Grades: ≥95%. CAS No. 116457-99-9. Molecular formula: C40H83N2O5PS. Mole weight: 735.1. | |
| Thioguanine | Thioguanine incorporation alters the DNA cleavage induced by topoisomerase II in the presence and absence of etoposide. Uses: Antimetabolites, antineoplastic. Synonyms: thioguanine|6-Thioguanine|154-42-7|Tioguanine|2-Amino-6-mercaptopurine|6-Mercaptoguanine|Tioguanin|Tabloid|2-Amino-6-purinethiol|Lanvis|2-Amino 6MP|2-Aminopurin-6-thiol|2-Aminopurine-6-thiol|2-Aminopurine-6(1H)-thione|Wellcome U3B|6-Mercapto-2-aminopurine|2-Amino-9H-purine-6-thiol|6-TG|2-Amino-6-merkaptopurin|Tioguaninum|Guanine, thio-|Tioguanina|6H-Purine-6-thione, 2-amino-1,7-dihydro-|2-Amino-1,7-dihydro-6H-purine-6-thione|BW 5071|Purine-6-thiol, 2-amino-|Purine-6(1H)-thione, 2-amino-|2-Amino-1,9-Dihydro-6h-Purine-6-Thione|NSC-752|Thioguanine Anhydrous|TG|Thioguanine Hemihydrate|THG|NSC 752|2-Amino-1,7-dihydro-6H-purin-6-thion|X 27|UNII-WIX31ZPX66|Tioguanine (INN)|Thioguanine, anhydrous|9H-Purine-6-thiol, 2-amino-|2-amino-1, 9-dihydropurine-6-thione|CHEMBL727|WIX31ZPX66|2-amino-3, 7-dihydro-6H-purine-6-thione|2-amino-6, 7-dihydro-3H-purine-6-thione|CHEBI: 9555|NSC752|Thioguanine2-Amino-6-purinethiol|2-Thioguanine|2-amino-1H-purine-6(9H)-thione|Tioguanine [INN] |2-amino-1, 7-di hydropurine-6-thione|NCGC00094792-01|DSSTox_CID_3652|2-Amino-6-MP|DSSTox_RID_77129|DSSTox_GSID_2365 2|Tioguaninum [INN-Latin]|.. Grades: >98%. CAS No. 154-42-7. Molecular formula: C5H5N5S. Mole weight: 167.19. | |
| Thiomuscimol | Thiomuscimol is a GABAA receptor agonist with IC50 value of 19 nM. It has been used as a photoaffinity label for the complex of GABA binding sites and the GABAA receptor. Synonyms: 5-(Aminomethyl)isothiazol-3(2H)-one; 3(2H)-Isothiazolone,5-(aminomethyl)-; 5-Aminomethyl-3-isothiazolol. Grades: ≥95%. CAS No. 62020-54-6. Molecular formula: C4H6N2OS. Mole weight: 130.2. | |
| Thioperamide | Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist (Ki = 25 and 27 nM for human recombinant H3 and H4 receptors, respectively). Thioperamide can cross the blood-brain barrier freely. Synonyms: N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide. Grades: ≥99% by HPLC. CAS No. 106243-16-7. Molecular formula: C15H24N4S. Mole weight: 292.44. | |
| Thioperamide maleate | Thioperamide maleate is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. Synonyms: MR-12842; SR-01000075293; (Z)-but-2-enedioic acid;N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide. Grades: ≥98%. CAS No. 148440-81-7. Molecular formula: C15H24N4S·C4H4O4. Mole weight: 408.5. | |
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