BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SKF 83959 hydrobromide | SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki = 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors, respectively), exhibiting anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. SKF 83959 also acts as an allosteric modulator of the σ1 receptor via potentiating binding of the σ1 receptor. Synonyms: SKF83959 hydrobromide; SKF-83959 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol hydrobromide; 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, hydrobromide (1:1); 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, monohydrobromide. Grades: ≥98% by HPLC. CAS No. 67287-95-0. Molecular formula: C18H20ClNO2.HBr. Mole weight: 398.73. |  |
| SKF 86002 dihydrochloride | SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM) with anti-inflammatory activity. SKF 86002 was indicated inhibition of LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). It also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 = 10 and 100 μM, respectively). Synonyms: SKF 86002 dihydrochloride; SKF86002 dihydrochloride; SKF-86002 dihydrochloride; 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride. Grades: ≥98% by HPLC. CAS No. 116339-68-5. Molecular formula: C16H12FN3S.2HCl. Mole weight: 370.27. | |
| SKF 86466 hydrochloride | SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki = 13 and 17 nM, respectively). SKF 86466 exhibits antihypertensive activity in a rat model. Uses: Adrenergic alpha-antagonists. Synonyms: SKF 86466 hydrochloride; SKF86466 hydrochloride; SKF-86466 hydrochloride; 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride. Grades: ≥98% by HPLC. CAS No. 86129-54-6. Molecular formula: C11H14ClN.HCl. Mole weight: 232.15. | |
| SKF 97541 | SKF 97541 is a highly potent GABAB agonist, and also acts as a GABAA-ρ antagonist. SKF 97541 exhibits sedative effects in mammals and has the potential to be used in the treatment of various addictions due to neurochemical imbalances. Uses: Potential treatment of addictions. Synonyms: SKF 97541; SKF97541; SKF-97541; 3-Aminopropyl(methyl)phosphinic acid; 3-Apmpa. CAS No. 127729-35-5. Molecular formula: C4H12NO2P. Mole weight: 137.12. | |
| SKLB1002 | SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy. Synonyms: SKLB1002; SKLB 1002; SKLB-1002. Grades: 0.98. CAS No. 1225451-84-2. Molecular formula: C13H12N4O2S2. Mole weight: 320.39. | |
| SKLB-1028 | SKLB1028 is a novel Bcr-abl tyrosine kinase inhibitor, Epidermal growth factor inhibitor and Fms-like tyrosine kinase 3 inhibitor originated by CSPC Ouyi Pharmaceutical. Phase-I clinical trials in Acute myeloid leukaemia (Monotherapy, Second-line therapy or greater) in China is on-going. Uses: Acute myeloid leukaemia. Synonyms: SKLB-1028; SKLB 1028; SKLB1028; 9-isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine. Grades: 98%. CAS No. 1350544-93-2. Molecular formula: C24H29N9. Mole weight: 443.56. | |
| SKLB-23bb | SKLB-23bb is an orally bioavailable and selective HDAC6 inhibitor exhibiting microtubule-disrupting ability. Synonyms: HDAC6-IN-1; N-hydroxy-4-[2-methoxy-5-[methyl-(2-methylquinazolin-4-yl)amino]phenoxy]butanamide. CAS No. 1815580-06-3. Molecular formula: C21H24N4O4. Mole weight: 396.44. | |
| SKLB610 | SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated. Synonyms: SKLB610; SKLB 610; SKLB-610. Grades: 0.98. CAS No. 1125780-41-7. Molecular formula: C21H16F3N3O3. Mole weight: 415.372. | |
| SL327 | SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization. Synonyms: SL 327; SL-327. Grades: 0.98. CAS No. 305350-87-2. Molecular formula: C16H12F3N3S. Mole weight: 335.348. | |
| SL 651498 | SL 651498 is a GABAA agonist selectively for subtype α2, and has the potential for the treatment of anxiety. Uses: Potential treatment of anxiety. Synonyms: SL-65,1498; SL-651498; SL65,1498; SL651498; SL 65,1498; SL 651498; 6-fluoro-9-methyl-2-phenyl-4-(pyrrolidine-1-carbonyl)pyrido[3,4-b]indol-1-one. Grades: 99%. CAS No. 205881-86-3. Molecular formula: C23H20FN3O2. Mole weight: 389.42. | |
| SLIGRL-NH2 trifluoroacetate salt | SLIGRL-NH2 is a recombinant peptide PAR2 activator (EC50 = ~5 μM), without activity for PAR1. Synonyms: SLIGRL-NH2 TFA. Grades: ≥98%. Molecular formula: C29H56N10O7·xCF3COOH. Mole weight: 656.82. | |
| SLV 320 | SLV 320 is a potent and selective adenosine A1 receptor antagonist (Ki = 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors, respectively). SLV320 prevents nephrectomy-dependent rise in plasma levels of creatinine kinase (CK), ALT and AST. SLV 320 inhibits cardiac fibrosis and attenuates albuminuria, without affecting blood pressure in animal models of chronic renal failure. Synonyms: SLV320; SLV-320; SLV 320; Derenofylline; trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol. Grades: ≥99% by HPLC. CAS No. 251945-92-3. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| SM 16 | SM 16 is a potent and selective TGF-β receptor type 1 (TGF-βRI) inhibitor with IC50 value of 64 nM in luciferase assay. SM 16 blocked TGF-beta and activin-induced Smad2/3 phosphorylation and TGF-beta-induced plasminogen activator inhibitor (PAI)-luciferase activity in cells. Synonyms: SM-16; SM16; 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide. Grades: ≥98% by HPLC. CAS No. 614749-78-9. Molecular formula: C25H26N4O3. Mole weight: 430.5. | |
| SM-21 maleate | SM-21 maleate is a potent and selective σ2 antagonist that can increase acetylcholine release at central muscarinic synapses. SM-21 is used as a potent analgesic and nootropic agent. Uses: Analgesic and nootropic agent. Synonyms: SM-21 maleate; SM 21 maleate; SM21 maleate; (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate. Grades: ≥99% by HPLC. CAS No. 155059-42-0. Molecular formula: C18H24ClNO3.C4H4O4. Mole weight: 453.92. | |
| SM 324405 | SM 324405 is a potent TLR7 agonist (EC50 = 50 nM). Synonyms: SM-324405; SM324405; SM 324405; Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate. CAS No. 677773-91-0. Molecular formula: C19H23N5O4. Mole weight: 385.42. | |
| SMANT hydrochloride | SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. SMANT inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy. Synonyms: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1177600-74-6. Molecular formula: C16H23BrN2O.HCl. Mole weight: 375.73. | |
| SMBA 1 | SMBA 1 is a selelctive and high affinity Bax activator (Ki = 43.3 nM) that binds to the S184 binding pocket and inhibits Bax phosphorylation. SMBA 1 exhibits no affinity for other Bcl-2 family members, including Bcl-2, Bak and Bid. SMBA 1 induces apoptosis in lung cancer cell lines which expresses high levels of Bax. Synonyms: SMBA1; SMBA-1; SMBA 1; NSC-408730; NSC408730; NSC 408730; CYD-1-94; CYD 1 94; CYD194; 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol. Grades: ≥98% by HPLC. CAS No. 906440-37-7. Molecular formula: C20H13NO3. Mole weight: 315.32. | |
| (S)-MCPG | (S)-MCPG, the active isomer of (RS)-MCPG, is a non-selective group I/group II mGluR antagonist. Synonyms: (S)-α-Methyl-4-carboxyphenylglycine; (+)-MCPG; 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid. Grades: ≥99% by HPLC. CAS No. 150145-89-4. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
| SMER18 | SMER18 is a small molecule enhancer of rapamycin. It act as a mTOR-independent autophagy inducer. It is a positive regulators of autophagy acting independently of rapamycin. It has additive protective effects on the clearance and toxicity of mutant aggregate-prone proteins in vitro. Uses: Smer18 has additive protective effects on the clearance and toxicity of mutant aggregate-prone proteins. Synonyms: SMER18; SMER 18; SMER-18. Grades: >98 %. CAS No. 944153-47-3. Molecular formula: C15H14ClNO2. Mole weight: 287.74. | |
| S-Methylisothiourea hemisulfate salt | (S)-Methylisothiourea sulfate is a more potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS). The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively. Synonyms: methyl carbamimidothioate;sulfuric acid. Grades: ≥98% (HPLC). CAS No. 867-44-7. Molecular formula: C4H14N4O4S3. Mole weight: 139.19. | |
| S-methyl-L-thiocitrulline hydrochloride | Cas No. 209589-59-3. | |
| SMK-17 | SMK-17 is a MEK1/2 inhibitor. It can inhibit MEK1 kinase activity in a non-ATP-competitive manner and it is highly selective to MEK1 and 2. SMK-17 can inhibit the growth of tumor cell lines in vitro. But it did not inhibit the phosphorylation of ERK5. SMK-17 selectively blocked the MAPK pathway signaling without affecting other signal pathways, which resulted in significant antitumor efficacy without notable side effects. Uses: Antitumor. Synonyms: SMK17; SMK 17; SMK17; N-(2-((2-chloro-4-iodophenyl)amino)-3,4-difluorophenyl)-4-(isopropylamino)piperidine-1-sulfonamide. Grades: 98%. CAS No. 765958-29-0. Molecular formula: C20H24ClF2IN4O2S. Mole weight: 584.85. | |
| SN 003 | SN 003 is a reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki = 3.4 and 7.9 nM at rat and human CRF1, respectively) that displays >1000-fold selectivity over CRF2 receptors. SN 003 was shown to inhibit CRF-induced ACTH release in vitro (IC50 = 241 nM). Synonyms: SN 003; SN003; SN-003; N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine; 1-(1-methoxybutan-2-yl)-N-(4-methoxy-2-methylphenyl)-6-methyltriazolo[4,5-c]pyridin-4-amine. Grades: ≥98% by HPLC. CAS No. 197801-88-0. Molecular formula: C19H25N5O2. Mole weight: 355.43. | |
| SN 2 | SN 2 is a novel and potent small molecule activator of TRPML3. Its EC50 value is 1.13 uM. It had a similar synergistic effect and reached up-to 10-fold enhancement of the combined response when compared with the individual responses. Synonyms: SN 2; SN2; SN-2; 5-mesityl-3-oxa-4-azatricyclo[5.2.1.0~2,6~]dec-4-ene. Grades: >98%. CAS No. 823218-99-1. Molecular formula: C17H21NO. Mole weight: 255.35. | |
| SN-6 | SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor that displays some selectivity for NCX1 (IC50 = 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3, respectively). SN-6 shows some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). SN-6 exhibits anti-ischemic activity. Synonyms: SN-6; SN 6; SN6; 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester. Grades: ≥99% by HPLC. CAS No. 415697-08-4. Molecular formula: C20H22N2O5S. Mole weight: 402.16. | |
| SNAP 5089 | SNAP 5089 is an α1A-adrenoceptor antagonist with >600-fold selectivity over other adrenoceptors (Ki = 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B and α2A subtypes respectively and 540 nM for L-type Ca2+ channels). SNAP 5089 exhibits an inhibitory effect on noradrenalin-induced contractions in rabbit vascular and lower urinary tissues. Synonyms: 3-Pyridinecarboxylic acid, 5-[[[3-(4,4-diphenyl-1-piperidinyl)propyl]amino]carbonyl]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-, methyl ester; Methyl 5-[[[3-(4,4-diphenyl-1-piperidinyl)propyl]amino]carbonyl]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-pyridinecarboxylate; SNAP5089; SNAP-5089; 2,6-Dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid N-(3-(4,4-diphenylpiperidine-1-yl)propyl]amide methyl ester. Grades: ≥95%. CAS No. 157066-76-7. Molecular formula: C36H40N4O5. Mole weight: 608.73. | |
| SNAP-8719 HCl | SNAP-8719, structurally very similar to BMY-7378, is a selective, orally active α1D-AR antagonist with lower binding affinity for the 5-HT1A receptor. Synonyms: (R)-8-(1-(4-(2,4,5-trifluorophenyl)piperazin-1-yl)propan-2-yl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride; SNAP-8719; SNAP 8719; SNAP8719. Grades: >98%. CAS No. 255893-38-0. Molecular formula: C22H29ClF3N3O2. Mole weight: 459.94. | |
| SNC 162 | SNC 162 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM), displaying > 8000-fold selectivity over μ-opioid receptors. SNC 162 is centrally active following systemic administration in vivo. Synonyms: SNC 162; SNC162; SNC-162; 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide. Grades: ≥99% by HPLC. CAS No. 178803-51-5. Molecular formula: C27H37N3O. Mole weight: 419.61. | |
| SNC 80 | SNC 80 is a potent and non-peptide δ-opioid agonist, displaying 2000-fold selectivity over μ-opioid receptors. SNC 80 exhibits antinociceptive as well as pro-convulsant effects in vivo. Synonyms: SNC80; SNC-80; SNC80; (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide; 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide. Grades: ≥98% by HPLC. CAS No. 156727-74-1. Molecular formula: C28H39N3O2. Mole weight: 449.64. | |
| SNG-1153 | SNG-1153 is an estrogen receptor ER-α36 modulator derived from icaritin which is purified from Epimedium Genus. SNG-1153 regulates ER-α36, induces phosphorylation of β-catenin, and down-regulates β-catenin, a crucial component of the WNT pathway. It plays a key role in tumor stem cells. Synonyms: 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]-; 3,5,7-Trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]-4H-1-benzopyran-4-one; Fukelading; SNG 1153; SNG1153. Grades: ≥95%. CAS No. 1446712-19-1. Molecular formula: C21H17F3O5. Mole weight: 406.35. | |
| (S)-(+)-Niguldipine hydrochloride | (S)-(+)-Niguldipine hydrochloride, the more active enantiomer of Niguldipine hydrochloride, acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM), and also is a L-type Ca2+ channel blocker. Uses: Antihypertensive agents. Synonyms: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[3-(4,4-diphenyl-1-piperidinyl)propyl] 5-methyl ester, hydrochloride (1:1), (4S)-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester, monohydrochloride, (4S)-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester, monohydrochloride, (S)-; (+)-Niguldipine hydrochloride; (S)-Niguldipine hydrochloride; B 8509-034; BY 934; Niguldipine hydrochloride. Grades: ≥95%. CAS No. 113145-69-0. Molecular formula: C36H39N3O6.HCl. Mole weight: 646.18. | |
| SNOG | SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). Uses: Bronchodilator agents. Synonyms: S-Nitroso-L-glutathione;S-Nitrosoglutathione; Nitrosoglutathione; Glutathione thionitrite; GNSO. Grades: ≥97%. CAS No. 57564-91-7. Molecular formula: C10H16N4O7S. Mole weight: 336.32. | |
| SNS-032 | SNS-032, also known as BMS-387032, is a 2-aminothiazole-derived, small-molecule cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDK inhibitor SNS-032 selectively binds to CDKs 2, 7, and 9, preventing their phosphorylation and activation; inhibition of CDK activity may result in cell cycle arrest, the induction of apoptosis and decreased tumor cell proliferation in susceptible tumor cell populations. This agent has been shown to sensitize radioresistant tumor cells to ionizing radiation. Synonyms: BMS-387032; BMS 387032; SNS 032; BMS387032; SNS032; 4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-; N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide; N-[5-[[(5-tert-Butyloxazol-2-yl)methyl]thio]thiazol-2-yl]piperidine-4-carboxamide. Grades: >98%. CAS No. 345627-80-7. Molecular formula: C17H24N4O2S2. Mole weight: 380.53. | |
| SNS-314 Mesylate | SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. Synonyms: SNS-314 Mesylate; SNS 314 Mesylate; SNS314 Mesylate. Grades: >98%. CAS No. 1146618-41-8. Molecular formula: C18H15ClN6OS2.CH4O3S. Mole weight: 527.04. | |
| SNX-2112 | SNX-2112 is an Hsp90 inhibitor which selectively binds to the ATP pocket of Hsp90α and Hsp90β with Ka of 30 nM and 30 nM. In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGFR, and AKT as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest. Synonyms: PF 04928473; PF04928473; PF-04928473; SNX-2112; SNX 2112; SNX2112. Grades: >98%. CAS No. 908112-43-6. Molecular formula: C23H27F3N4O3. Mole weight: 464.48. | |
| SNX-7081 | SNX-7081 is a novel small molecule inhibitor of Hsp90 that promotes cell cycle arrest and apoptosis of tumor cells. SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp70. NF-kappaB nuclear translocation was blocked by SNX-7081 at nanomolar concentrations, and cytokine production was potently inhibited. Growth factor activation of ERK and JNK signaling was significantly reduced by SNX-7081. NO production was also sharply inhibited. In animal models, SNX-4414 fully inhibited paw swelling and improved body weight. Synonyms: SNX 7081; SNX-7081; SNX7081. Grades: >98%. CAS No. 908111-22-8. Molecular formula: C24H31N3O3. Mole weight: 409.52. | |
| Sodium Channel inhibitor 1 | Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatment, exhibiting concentration-dependent efficacy in studies. Uses: Sodium channel inhibitor1 is an effective voltage-gated sodium channel blocker that could be used for pain treatment. Synonyms: Sodium Channel inhibitor 1; CHEMBL2164368; 7-FLUORO-3-OXO-2-(2-(PYRIDIN-2-YL)ETHYL)-N-(4-(TRIFLUOROMETHOXY)BENZYL)ISOINDOLINE-1-CARBOXAMIDE; SCHEMBL3900840. Grades: 98%. CAS No. 1198117-23-5. Molecular formula: C24H19F4N3O3. Mole weight: 473.42. | |
| Sodium Indanylcarbinicillin | Sodium Indanylcarbinicillin, a penicillin-derived, has been used as a β-lactam antibiotic which inhibits the synthesis of peptidoglycan, a key component of the bacterial cell wall. It also has been shown to reduce blood pressure in mammals. Uses: Anti-bacterial agents. Synonyms: (2S,5R,6R)-6-[[3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt; (2S,5R,6R)-6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; [2S-(2α,5α,6β)]-6-[[3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; CP 15464-2; Carbenicillin Indanyl Sodium; Carindacillin Sodium; Carindapen; GU-Pen; Geocillin; Indanyl Carbenicillin Sodium Salt; Monosodium Indanyl Carbenicillin; Sodium 5-indanylcarbenicillin; Sodium Indanylcarbenicillin; 4800-94-6 (Carbenicillin Disodium). Grades: >98%. CAS No. 26605-69-6. Molecular formula: C26H25N2NaO6S. Mole weight: 516.54. | |
| Sodium valproate | Valproic acid is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Uses: Anticonvulsants. Synonyms: Valproic Acid, Convulex, Depakote, Epilim, Stavzor, Vilapro. Grades: >98%. CAS No. 1069-66-5. Molecular formula: C8H15NaO2. Mole weight: 166.19. | |
| Sofinicline | Sofinicline is a novel nicotinic acetylcholine receptor agonist under development of Abbott Laboratories. Till now, no development was reported for Phase-II for Attention-deficit hyperactivity disorder in USA. Uses: Attention-deficit hyperactivity disorder. Synonyms: ABT-894; ABT 894; ABT894; A-422894; A-422894.0; A 422894.0; Sofinicline;(1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane. Grades: 98%. CAS No. 799279-80-4. Molecular formula: C10H11Cl2N3. Mole weight: 244.12. | |
| Solabegron hydrochloride | Solabegron hydrochloride is a selective β3-adrenergic receptor agonist used for the treatment of irritable bowel syndrome. Uses: Adrenergic beta-3 receptor agonists. Synonyms: 3'-[[2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3-carboxylic Acid Hydrochloride; 3'-[[2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3-carboxylic Acid Monohydrochloride; (R)-3'-((2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic Acid Hydrochloride; GW 427353B. Grades: ≥98%. CAS No. 451470-34-1. Molecular formula: C23H23ClN2O3.HCl. Mole weight: 447.361. | |
| Solifenacin hydrochloride | Muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence. Synonyms: Vesicare hydrochloride; YM905 hydrochloride; YM 905 hydrochloride; YM-905 hydrochloride. Grades: >98%. CAS No. 180468-39-7. Molecular formula: C23H27ClN2O2. Mole weight: 398.93. | |
| Sonepiprazole | Sonepiprazole is a selective, brain penetrating and orally bioactive antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM) with low affinity at other monoamine receptors (Ki > 2000 nM). Sonepiprazole was shown to induce c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine. Synonyms: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 170858-33-0. Molecular formula: C21H27N3O3S. Mole weight: 401.52. | |
| Sonepiprazole hydrochloride | Sonepiprazole hydrochloride is a selective dopamine D4 antagonist and displays low affinity for other dopamine receptors, and noradrenalin, serotonin and histamine receptor families (Ki > 2000 nM). Synonyms: PNU 101387 hydrochloride; PNU101387 hydrochloride; PNU-101387 hydrochloride; 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide hydrochloride. Grades: 98%. CAS No. 170857-36-0. Molecular formula: C21H27N3O3S.HCl. Mole weight: 437.98. | |
| Sotrastaurin | Sotrastaurin, also known as AEB-701, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. PKC, a family of serine/threonine protein kinases overexpressed in certain types of cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and the activation and survival of lymphocytes. Synonyms: AEB-071; AEB071; AEB 071. Grades: >98%. CAS No. 425637-18-9. Molecular formula: C25H22N6O2. Mole weight: 438.491. | |
| Sovilnesib | Sovilnesibum is a kinesin-like protein KIF18A inhibitor and antineoplastic. Synonyms: Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-. Grades: >98%. CAS No. 2410796-79-9. Molecular formula: C26H34F2N6O4S. Mole weight: 564.65. | |
| SP 100030 | SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). SP 100030 blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. It inhibits cytokine production selectively in T cells and exhibits minimal inhibitory effects on cytokine production in other cell types. Synonyms: SP-100030; SP 100030; SP100030; N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide. Grades: ≥99% by HPLC. CAS No. 154563-54-9. Molecular formula: C14H5ClF9N3O. Mole weight: 437.65. | |
| SP 141 | SP 141 is a cell-permeable and high affinity MDM2 inhibitor (Ki = 28 nM). SP 141 directly binds MDM2 to inhibit MDM2 expression and induce MDM2 autoubiquitination aw well as proteasomal degradation. SP 141 has been shown to attenuate growth of breast cancer xenograft tumors. Synonyms: SP-141; SP 141; SP141; 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole. Grades: ≥98% by HPLC. CAS No. 1253491-42-7. Molecular formula: C22H16N2O. Mole weight: 324.38. | |
| SP187 | SP187, also known as N-9-DNJ and UV-4B, is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo and used to treat dengue fever and influenza infection. Synonyms: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(9-methoxynonyl)piperidine-3,4,5-triol; N-9-Methoxynonyldeoxynojirimycin; SP-187; SP187; SP 187; N-9-DNJ; UV-4B; N9DNJ; UV4B; N 9 DNJ; UV 4B. Grades: 99.30%. CAS No. 615253-61-7. Molecular formula: C16H33NO5. Mole weight: 319.44. | |
| SP2509 | SP2509 inhibits the association of LSD1 with CoREST, increases promoter-specific H3K4Me3 and induces p53, p21 and C/EBP&alpha. SP2509 also significantly inhibits the colony growth and induces apoptosis of OCI-AML3. Synonyms: HCI-2509; SP2509; SP 2509; SP-2509. Grades: >98%. CAS No. 1423715-09-6. Molecular formula: C19H20ClN3O5S. Mole weight: 437.90. | |
| (-)-Sparteine sulfate pentahydrate | (-)-Sparteine sulfate pentahydrate is an alkaloid compound which could be used as in the treatment of antiarrhythmic by blocking sodium channel. Uses: (-)-sparteine sulfate pentahydrate is an alkaloid compound which could be used as in the treatment of antiarrhythmic by blocking sodium channel. Synonyms: LUPINIDINE;(-)-LUPINIDINE SULFATE PENTAHYDRATE;LUPINIDINE SULFATE PENTAHYDRATE;(-)-SPARTEINE SULFATE PENTAHYDRATE;SPARTEINE SULFATE PENTAHYDRATE;(-)-SPARTEINE SULFATE SALT PENTAHYDRATE;SPARTEINE SULFATE, CRYSTALLIZED;(-)-Sparteine sulfate pentahydrate. Grades: >99.0%(T). CAS No. 6160-12-9. Molecular formula: C15H26N2.H2SO4.5(H2O). Mole weight: 422.53. | |
| Spautin-1 | Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ?0.6-0.7 μM. Synonyms: Spautin-1; Spautin1; Spautin 1. Grades: 99%. CAS No. 1262888-28-7. Molecular formula: C15H11F2N3. Mole weight: 271.26. | |
| Spermidine trihydrochloride | Spermidine trihydrochloride is a polyamine that binds to NMDA receptor. Spermidine has been described as an agonist for its ability to enhance the binding of [3H]-MK801. It also acts as a NOS1 inhibitor. Synonyms: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride. CAS No. 334-50-9. Molecular formula: C7H19N3.3HCl. Mole weight: 254.63. | |
| Spermine | Spermine is an endogenous polyamine derived from spermidine. Spermine acts as an inhibitor of nNOS, and an antagonist of NMDA glutamate receptor. Synonyms: Gerontine; Musculamine; Neuridine; NSC 268508; 1,5,10,14-Tetraazatetradecane; N,N'-bis(3-aminopropyl)butane-1,4-diamine. Grades: ≥95%. CAS No. 71-44-3. Molecular formula: C10H26N4. Mole weight: 202.3. | |
| Spermine tetrahydrochloride | Spermine tetrahydrochloride is a polyamine that binds to and modulates NMDA receptor channel. Spermine also acts as a GluR inhibitor, PLCα inhibitor and PLCδ activator. Uses: Found widely in nature and essential for tissue growth; used as a tool in biochemical research; spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. formed from spermidine, it is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. spermine is associated with nucleic acids and is thought to stabilize helical structure, in particular, in viruses. Synonyms: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Neuridine tetrahydrochloride; Musculamine tetrahydrochloride. Grades: >98.0%(T)(N). CAS No. 306-67-2. Molecular formula: C10H26N4.4HCl. Mole weight: 348.19. | |
| (S)-(-)-Pindolol | (S)-(-)-Pindolol, the more active enantiomer of pindolol, is 5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. Synonyms: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; AGI-001; MT-102; AGI001; MT102; AGI 001; MT 102; Espindolol; (S)-(-)-Pindolol. Grades: ≥99% by HPLC. CAS No. 26328-11-0. Molecular formula: C14H20N2O2. Mole weight: 248.32. | |
| Spiperone hydrochloride | Spiperone hydrochloride is a 5-HT2A and selective dopamine D2 receptor antagonist (Ki = 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) used as an antipsychotic. It also acts as an activator of calcium-activated chloride channels (EC50 = 9.3 μM). Uses: Antipsychotic. Synonyms: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride; SR-01000000261. Grades: ≥98% by HPLC. CAS No. 2022-29-9. Molecular formula: C23H26FN3O2.HCl. Mole weight: 431.94. | |
| Spirapril | Spirapril is an ACE inhibitor. It can be used for the treatment of hypertension. Spirapril belongs to dicarboxy group of ACE inhibitors. Uses: Hypertension. Synonyms: BRN4277924; BRN-4277924; BRN 4277924; Spirapril; Spiraprilum; Espirapril;(S)-7-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid; 94841-17-5(hydrochloride). Grades: 98%. CAS No. 83647-97-6. Molecular formula: C22H30N2O5S2. Mole weight: 466.61. | |
| Spiroxatrine | Spiroxatrine is a 5-HT1A antagonist and a potent α2C adrenergic receptor antagonist. Spiroxatrine exhibits great anxiolytic effects in combination with buspirone. Synonyms: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one. CAS No. 1054-88-2. Molecular formula: C22H25N3O3. Mole weight: 379.46. | |
| SPK-601 | SPK-601 is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor,a useful antimicrobial agent. Synonyms: LMV-601; LMV601; LM -601; SPK601; SPK-601; SPK 601. Grades: >98%. CAS No. 1096687-52-3. Molecular formula: C11H15KOS2. Mole weight: 266.46. | |
| sPLA2 Inhibitor | sPLA2 Inhibitor is an orally active inhibitor of secreted phospholipases A2 IIA (sPLA2-IIA). It exhibits anti-inflammatory effects, and attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats. Synonyms: KH064; Secretory Phospholipase A2 Inhibitor; (S)-5-(4-Benzyloxy-phenyl)-4-(7-phenyl-heptanoylamino)-pentanoic acid; (4S)-4-(7-phenylheptanoylamino)-5-(4-phenylmethoxyphenyl)pentanoic acid. Grades: ≥95%. CAS No. 393569-31-8. Molecular formula: C31H37NO4. Mole weight: 487.6. | |
| (S)-PPHT hydrochloride | (S)-PPHT hydrochloride is a potent and selective D2 agonist. Uses: Dopamine agonists. Synonyms: (6S)-6-[2-phenylethyl(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride. Grades: 98%. CAS No. 159795-62-7. Molecular formula: C21H27NO.HCl. Mole weight: 345.91. | |
| SQ109 | SQ109 is a novel antitubercular drug. It was screened out from a big chemical library designed around the active pharmacophore of ethambutol (EMB). SQ109 displayed potent activity against all the substrains of Mtb including XDR- and MDR-TB clinical strains. Synonyms: SQ109; SQ-109; SQ 109; NSC 722041; NSC-722041; NSC722041. Grades: >98%. CAS No. 502487-67-4. Molecular formula: C22H38N2. Mole weight: 330.55. | |
| Squalamine | Squalamine is a naturally derived broad-spectrum antibiotic that is predominantly derived from the livers of dogfish and other shark species. Squalamine is undergoing trials for treatment of non-small cell lung cancer (stage I/IIA) as well as general phase I pharmacokinetic studies. In 2005, the Food and Drug Administration granted squalamine Fast Track status for approval for treatment of age-related macular degeneration. However, the Genaera Corporation, the company that has done the most work with squalamine, discontinued trials for its use in treating prostate cancer and wet age-related macular degeneration in 2007. The Squalamine project was acquired by Ohr Pharmaceutical from the now liquidated Genaera, with the prospect of continuing the development of this drug to treat wet age-related macular degeneration. Synonyms: MSI 1256; MSI-1256; MSI1256. Grades: ≥98% (HPLC). CAS No. 148717-90-2. Molecular formula: C34H65N3O5S. Mole weight: 627.96. | |
| SR-01000946410 | SR-01000946410 is a structural analog of PGE2 and a selective agonist for the EP2 receptor subtype. It binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor. It does not bind appreciably to any of the other murine EP receptors. BIt has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1 methyl ester; TR 4979. Grades: ≥98%. CAS No. 69685-22-9. Molecular formula: C24H40O5. Mole weight: 408.6. | |
| SR 0987 | SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay) that induces IL-17 expression and decreases PD-1 expression in T cells in vitro. Synonyms: SR-0987; SR0987; SR 0987; 2-Chloro-N-[4-[2, 2, 2-trifluoro-1-hydroxy-1- (trifluoromethyl) ethyl]phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 303126-97-8. Molecular formula: C16H10ClF6NO2. Mole weight: 397.7. | |
| SR1001 | Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Synonyms: SR 1001; SR-1001. Grades: >98%. CAS No. 1335106-03-0. Molecular formula: C15H13F6N3O4S2. Mole weight: 477.4. | |
| SR1078 | SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays. Synonyms: SR 1078; SR-1078. Grades: >98%. CAS No. 1246525-60-9. Molecular formula: C17H10F9NO2. Mole weight: 431.25. | |
| SR 11237 | SR 11237 is a pan retinoid X receptor (RXR) agonist with no RAR activity. Synonyms: SR12813; SR 12813; SR-12813. 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid. Grades: ≥98% by HPLC. CAS No. 146670-40-8. Molecular formula: C24H28O4. Mole weight: 380.48. | |
| SR121566A | SR121566A, a non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, has been shown to block platelet aggregation induced by a wide variety of agonists including HIT serum/heparin, reduced in a dose-dependent manner the HIT serum/heparin-induced, platelet mediated expression and release of the above mentioned proteins. Synonyms: 3-[[1-(carboxymethyl)piperidin-4-yl]-[4-(4-methanehydrazonoylphenyl)-1,3-thiazol-2-yl]amino]propanoic acid; CTK0H1193; 1-Piperidineaceticacid, 4-[[4-[4-(aminoiminomethyl)phenyl]-2-thiazolyl](2-carboxyethyl)amino]-. CAS No. 180144-61-0. Molecular formula: C20H25N5O4S. Mole weight: 431.51. | |
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