BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SB 328437 | SB 328437 is a potent and selective CCR3 antagonist. Synonyms: methyl 2-naphthoylamino-3-(4-nitrophenyl)propionate; SB328437; SB 328437; SB-328437. CAS No. 247580-43-4. Molecular formula: C21H18N2O5. Mole weight: 378.38. |  |
| SB-334867 | SB-334867, with sedative and anorectic effects, it is the first non-peptide selective antagonist of orexin receptor subtype OX1 (pKb= 7.2) with 50 -fold selectivity for OX1 over OX2 receptors. in vitro: inhibited the orexin-A (10 nM) and orexin-B (100 nM). Synonyms: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hydrochloride SB 334867-A SB 334867A SB-334867 SB-334867-A SB-334867A SB3348. Grades: >99 %. CAS No. 249889-64-3. Molecular formula: C17H13N5O2. Mole weight: 319.32. | |
| SB-366791 | SB-366791 is a potent, and selective cinnamide TRPV1 antagonist (pA2 = 7.71 at hVR1) with IC50 of 5.7±1.2 nM. Uses: A potent, and selective cinnamide trpv1 antagonist. Synonyms: SB-366791; SB 366791; SB366791. N-(4-Methoxyphenyl)-4-chlorocinnamamide;3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide. Grades: ≥98%. CAS No. 472981-92-3. Molecular formula: C16H14ClNO2. Mole weight: 287.74. | |
| SB 399885 hydrochloride | SB 399885 hydrochloride is a brain penetrating and orally active 5-HT6 antagonist, displaying > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi = 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors, respectively). Synonyms: SB 399885 hydrochloride; SB399885 hydrochloride; SB-399885 hydrochloride; N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 402713-81-9. Molecular formula: C18H21Cl2N3O4S.HCl. Mole weight: 482.81. | |
| SB408124 | SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. Synonyms: SB-408124; SB 408124; SB408124. Grades: >98%. CAS No. 288150-92-5. Molecular formula: C19H18F2N4O. Mole weight: 356.37. | |
| SB-408124 (Hydrochloride) | SB-408124 (Hydrochloride) is the hydrochloride salt form of SB-408124. SB-408124 is a selective antagonist of OX1 (for human OX1 Kb= 21.7nM; for human OX2 Kb=1405nM). In vivo: after oral administration it moderates Orexin-A blocking the vasopressin (VP) l. Synonyms: 1-(6, 8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea; hydrochlorideSB-408124 (Hydrochloride)1431697-90-3C19H18F2N4O.ClH3024AHCS-1073; HY-76612; W-5807; SB-408124 (Hydrochloride); CS 1073; HY 76612; W 5807; SB 408124 (Hydrochloride); CS1073; HY76612; W5807; SB408124 (Hydrochloride);1-(6,8-Difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea hydrochloride. CAS No. 1431697-90-3. Molecular formula: C19H19ClF2N4O. Mole weight: 392.84. | |
| SB-423562 | SB-423562 is a short-acting calcium sensitive receptor (CaR) antagonist. Synonyms: UNII-615K7YBS59. Grades: 98%. CAS No. 351490-27-2. Molecular formula: C26H32N2O4. Mole weight: 436.5. | |
| SB 452533 | SB 452533 is a potent and selective TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Synonyms: SB452533; SB 452533; SB-452533. N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea; 1-(2-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea. Grades: ≥98% by HPLC. CAS No. 459429-39-1. Molecular formula: C18H22BrN3O. Mole weight: 376.29. | |
| SB-505124 hydrochloride | SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β-induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells. Synonyms: SB 505124 hydrochloride; SB505124 hydrochloride; SB505124 HCl; SB 505124 HCl; SB-505124 HCl. Grades: >98%. CAS No. 356559-13-2. Molecular formula: C20H22ClN3O2. Mole weight: 371.86. | |
| SB-590885 | SB-590885 is a novel triarylimidazole that selectively inhibits Raf kinases. SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration. Malignant cells expressing oncogenic B-Raf show selective inhibition of mitogen-activated protein kinase activation, proliferation, transformation, and tumorigenicity when exposed to SB-590885, whereas other cancer cell lines and normal cells display variable sensitivities or resistance to similar treatment. Synonyms: SB590885; SB 590885. Grades: 0.98. CAS No. 405554-55-4. Molecular formula: C27H27N5O2. Mole weight: 453.54. | |
| SB 611812 | SB 611812 is a urotensin-II (UT) antagonist that inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. SB 611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation, and decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling. Synonyms: SB-611812; SB 611812; SB611812. 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 345892-71-9. Molecular formula: C17H16Cl3F3N2O3S. Mole weight: 491.74. | |
| SB 612111 hydrochloride | SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki = 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors, respectively). SB 612111 exhibits antagonist activity at the pronociceptive action of nociceptin in an acute pain model. SB 612111 potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride. Grades: ≥97% by HPLC. CAS No. 371980-94-8. Molecular formula: C24H29Cl2NO.HCl. Mole weight: 454.86. | |
| SB-649868 | SB-649868 is a novel, orally active dual orexin receptor antagonist of orexin(OX)1 and OX2 receptor (pKi=9.4 and 9.5 at the OX1 and OX2 receptor, respectively), potentially for the treatment of insomnia and sleep disorder. Synonyms: N-[[(2S)-1-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]piperidin-2-yl]methyl]-1-benzofuran-4-carboxamide; (14C)SB 649868; (14C)SB-649868; (14C)SB649868; N-((1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide; SB 649868; SB-649868; SB649868; GSK-649868; GSK-649868; GSK649868. CAS No. 380899-24-1. Molecular formula: C26H24FN3O3S. Mole weight: 477.55. | |
| SB 657510 | SB 657510 is a selective urotensin-II (UT) receptor/GRP14 antagonist (Ki = 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors, respectively). SB 657510 was also shown to inhibit U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonize the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). Synonyms: SB 657510; SB657510; SB-657510; 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 474960-44-6. Molecular formula: C19H22BrClN2O5S. Mole weight: 505.81. | |
| SB-674042 | SB-674042 is potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM), by binding with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells. Uses: Potent and selective non-peptide orexin ox1 receptor antagonist. Synonyms: SB 674042; SB-674042; SB674042; [5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone. Grades: ≥98%. CAS No. 483313-22-0. Molecular formula: C24H21FN4O2S. Mole weight: 448.51. | |
| SB 699551 dihydrochloride | SB 699551 is a selective 5-HT5A receptor antagonist (pKi = 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors, respectively). Synonyms: SB 699551 dihydrochloride; SB699551 dihydrochloride; SB-699551 dihydrochloride; N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 864741-95-7. Molecular formula: C34H45N3O.2HCl. Mole weight: 584.66. | |
| SB 706375 | SB 706375 is a high affinity and non-peptide antagonist of the mammalian urotensin-II (UT) receptor displaying ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones. SB 706375 also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Synonyms: SB-706375; SB 706375; SB706375. 2-Bromo-4, 5-dimethoxy-N-[3-[[ (3R) -1-methyl-3-pyrrolidinyl]oxy]-4- (trifluoromethyl) phenyl]benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 733734-61-7. Molecular formula: C20H22BrF3N2O5S. Mole weight: 539.36. | |
| SB 706504 | SB 706504 is a p38 MAPK inhibitor. SB 706504 inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs), and it also suppresses LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Synonyms: SB 706504; SB706504; SB-706504; N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine; 1-cyano-2-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine. Grades: ≥98% by HPLC. CAS No. 911110-38-8. Molecular formula: C24H19F3N8O. Mole weight: 492.46. | |
| SB 742457 hydrochloride | SB 742457 hydrochloride is a selective 5-HT6 antagonist with >100-fold selectivity over other receptors. It is a potential agent added to stabilize donepezil treatment in subjects with mild-to-moderate Alzheimer's disease. Uses: Potential treatment of alzheimer's disease in combination with donepezil. Synonyms: GSK-742457 hydrochloride; RVT-101 hydrochloride; SB-742457 hydrochloride; GSK 742457 hydrochloride; RVT 101 hydrochloride; SB 742457 hydrochloride; GSK742457 hydrochloride; RVT101 hydrochloride; SB742457 hydrochloride; Intepirdine hydrochloride; 3-Phenylsulfonyl-8-piperazin-1-yl-quinoline hydrochloride. Grades: 99%. CAS No. 607742-55-2. Molecular formula: C19H19N3O2S.HCl. Mole weight: 389.9. | |
| SB-743921 HCl | SB-743921 is a synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. Synonyms: SB-743921; SB 743921; SB743921. Grades: >98%. CAS No. 940929-33-9. Molecular formula: C31H34Cl2N2O3. Mole weight: 553.524. | |
| SB 772077B dihydrochloride | SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC50 ~ 5.6 nM at recombinant human ROCK1 and 2) exhibiting potent vasodilator activity. SB 772077B decreases pulmonary and systemic arterial blood pressure levels and increases cardiac output. Synonyms: SB-7720770 2HCl; SB 7720770 2HCl; SB7720770 2HCl; SB-7720770 dihydrochloride; SB 7720770 dihydrochloride; SB7720770 dihydrochloride; (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 607373-46-6. Molecular formula: C15H18N8O2.2HCl. Mole weight: 415.28. | |
| S(-)-BAY K 8644 | S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the enantiomer of (±)-Bay K 8644. It increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked further stimulatio. It enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or (+/-)-Bay T 5006, reflecting the differences in coronary constrictor activity. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. It can enable reprogramming of mouse embryonic fibroblasts after transduction with Oct4/Klf when combined with BIX01294. Uses: S(-)-bay k 8644 has positive inotropic, vasoconstrictive and behavioral effects. Synonyms: Methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate;Bay-K-8644 (S)-(-)-;(S)-(-)-Bay-K-8644;(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;S-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester;[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester. Grades: >99 %. CAS No. 98625-26-4. Molecular formula: C16H15F3N2O4. Mole weight: 356.30. | |
| SBE13 | SBE13 is a cell-permeable highly potent polo-like kinase (Plk1) inhibitor that targets the inactive conformation of the kinase. Its IC50 value is 0.2 nM. It does not effect the activity of Plk2, Plk3 and Aurora A kinases. It may be used in cell signaling studies. Uses: Sbe13 may be used in cell signaling studies. Synonyms: SBE13; SBE 13; SBE-13; STK510569;N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine. Grades: >98%. CAS No. 775294-82-1. Molecular formula: C24H27ClN2O4. Mole weight: 442.94. | |
| SBE-13 HCl | SBE13 is a cell-permeable highly potent polo-like kinase (Plk1) inhibitor that targets the inactive conformation of the kinase. SBE13 does not effect the activity of Plk2, Plk3, Aurora A kinases. Synonyms: SBE 13 HCl; SBE13 HCl. Grades: 0.98. CAS No. 1052532-15-6. Molecular formula: C24H28Cl2N2O4. Mole weight: 479.398. | |
| SC26304 | SC26304, also called as spirolactone, inhibited the effects of aldosterone on urinary K+:Na+ ratios and the binding of [3H]aldosterone to renal cytoplasmic and nuclear receptors in vivo. Synonyms: propan-2-yl (7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-carboxylate; SC 26304; SC-26304. CAS No. 41020-79-5. Molecular formula: C26H36O5. Mole weight: 428.56. | |
| (S)-C33 | (S)-C33 is a potent and selective PDE9 inhibitor (IC50 = 11 nM). Synonyms: PDE9-IN-(S)-C33; PDE9IN(S)C33; PDE9 IN (S) C33; (S)-C33; 49D; 6-[[(1S)-1-(4-Chlorophenyl)ethyl]amino]-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. Grades: ≥98% by HPLC. CAS No. 2066488-39-7. Molecular formula: C18H20ClN5O. Mole weight: 357.84. | |
| SC-514 | SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. Synonyms: GK 01140; GK01140; GK-01140; SC-514; SC 514; SC514. Grades: >98%. CAS No. 354812-17-2. Molecular formula: C9H8N2OS2. Mole weight: 224.3. | |
| SC-560 | SC-560 is an orally active and highly selective cyclooxygenase-1 (COX-1) inhibitor with IC50=0.009 μM for COX-1, and 6.3 μM for COX-2. SC-560 also significantly reduces ovarian surface epithelial tumor growth in vivo by causing cell cycle arrest at the G1 phase. Uses: Cyclooxygenase inhibitors. Synonyms: 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole; 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole; SC 560; SC-560; SC560. Grades: >98%. CAS No. 188817-13-2. Molecular formula: C17H12CIF3N2O. Mole weight: 352.74. | |
| SC57666 | A selective COX2 inhibitor (IC50= 26 nM). Synonyms: 1-fluoro-4-[2-(4-methylsulfonylphenyl)cyclopenten-1-yl]benzene; SC 57666; SC-57666. CAS No. 158959-32-1. Molecular formula: C18H17FO2S. Mole weight: 316.39. | |
| SC66 | SC66 is a novel and potent AKT inhibitor, which reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reduction in total and phospho-AKT levels. Synonyms: SC66; SC66; SC 66. Grades: 98%. CAS No. 871361-88-5. Molecular formula: C18H16N2O. Mole weight: 276.33. | |
| SC79 | SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation. Synonyms: SC-79; SC 79; SC79. Grades: 98%. CAS No. 305834-79-1. Molecular formula: C17H17ClN2O5. Mole weight: 364.78. | |
| SC-9 | SC-9 is a potent activator of protein kinase C in the presence of Ca2+. Synonyms: SC-9; SC 9; SC9; 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide. Grades: ≥99% by HPLC. CAS No. 102649-78-5. Molecular formula: C22H24ClNO2S. Mole weight: 401.95. | |
| SCH-1473759 | SCH-1473759 is a novel sub-nanomolar Aurora A/B inhibitor. SCH 1473759 was active against a large panel of tumor cell lines from different tissue origin and genetic backgrounds. SCH-1473759 demonstrated potent mechanism-based activity, and activity was shown to be enhanced in combination with taxanes and KSP inhibitors. Synonyms: SCH1473759; SCH 1473759. Grades: 0.98. CAS No. 1094069-99-4. Molecular formula: C20H26N8OS. Mole weight: 426.54. | |
| SCH1473759 (HCl salt) | The hydrochloride salt form of SCH-1473759, a new sub-nanomolar Aurora A/B inhibitor which could result in cell death by inhibiting Aurora kinases. It is proved to have oral bioavailability as well as high cell potency with high intrinsic aqueous solubili. Uses: The hydrochloride salt form of sch-1473759 which could result in cell death by inhibiting aurora kinases. Synonyms: SCH-1473759 (hydrochloride); SCH 1473759 (hydrochloride); SCH1473759 (hydrochloride); CHEMBL1650533; CS-3477; CS 3477; CS3477. Grades: 95%. CAS No. 1094067-13-6. Molecular formula: C20H27ClN8OS. Mole weight: 463.00. | |
| SCH 221510 | SCH 221510 is a potent and selective nociceptin opioid receptor (NOP) agonist (EC50 = 12, 693, 683 and 8071 nM, and Ki = 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors, respectively). SCH 221510 exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo. SCH 221510 is used as the therapy of neuropathic and inflammatory pain. Uses: Potential anti-inflammatory agent. Synonyms: SCH221510; SCH 221510; SCH-221510; 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol. Grades: ≥99% by HPLC. CAS No. 322473-89-2. Molecular formula: C28H31NO. Mole weight: 397.55. | |
| SCH 23390 hydrochloride | SCH 23390 hydrochloride is the hydrochloride salt of SCH 23390 which is a dopamine receptor antagonist. SCH 23390, a halobenzazepine, is a selective antagonist of the dopamine D1-like receptor subtypes D1 (Kis = 0.2 nM) and D5 (Kis = 0.3 nM). Synonyms: SCH 23390 hydrochloride; SCH-23390 hydrochloride; SCH23390 hydrochloride; (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride. CAS No. 125941-87-9. Molecular formula: C17H19Cl2NO. Mole weight: 324.24. | |
| SCH 28080 | SCH 28080 is a potent inhibitor of H+/K+-ATPase (IC50 = 20 nM). SCH 28080 binds to the K+ recognition site and is competitive with respect to K+. SCH 28080 blocks gastric acid secretion in vitro and in vivo via inhibiting gastric H+/K+-ATPase. Uses: Anti-ulcer agents. Synonyms: SCH 28080; SCH28080; SCH-28080; 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile; Schering compound 28080. Grades: ≥99% by HPLC. CAS No. 76081-98-6. Molecular formula: C17H15N3O. Mole weight: 277.33. | |
| SCH 336 | SCH 336 is a potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM) with 100-fold selectivity over CB1. SCH 336 has been shown to increase forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. It inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and suppresses antigen-induced lung eosinophilia in a mouse allergy model. Synonyms: SCH-336; SCH 336; SCH336. N- [ (1S) -1- [4- [ [4-Methoxy-2- [ (4-methoxyphenyl) sulfonyl] phenyl] sulfonyl] phenyl] ethyl] methanesulfonamide. Grades: ≥98% by HPLC. CAS No. 447459-51-0. Molecular formula: C23H25NO8S3. Mole weight: 539.64. | |
| SCH 39166 hydrobromide | SCH 39166 hydrobromide is a high affinity dopamine D1/D5 receptor antagonist (Ki = 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively). SCH 39166 is used in the treatment of schizophrenia, cocaine addiction and obesity. Uses: The treatment of schizophrenia, cocaine addiction and obesity. Synonyms: SCH 39166 hydrobromide; SCH39166 hydrobromide; SCH-39166 hydrobromide; (6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide; Ecopipam hydrobromide. Grades: ≥99% by HPLC. CAS No. 1227675-51-5. Molecular formula: C19H20ClNO.HBr. Mole weight: 394.73. | |
| Sch412348 | 412348 is an adenosine A2A receptor antagonist with anti-Parkinsonian activity in both rodent andprimate animal models. Because of its high affinity for the adenosine A2A receptor and pronounced selectivity over the adenosine A1 receptor,SCH 412348 is an excellent tool compound to assess the role of the adenosine A2A receptorinmovement. Uses: Adenosine a2 receptor antagonists. Synonyms: (7-(2-(4-difluorophenyl)-1-piperazinyl)ethyl)-2-(2-furanyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine; SCH 412348; SCH-412348; SCH412348. CAS No. 377727-26-9. Molecular formula: C22H21F2N9O. Mole weight: 465.46. | |
| SCH 442416 | SCH 442416 is a very selective, high affinity A2A antagonist. Synonyms: SCH-442416; SCH 442416; SCH442416. 2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine. CAS No. 316173-57-6. Molecular formula: C20H19N7O2. Mole weight: 389.42. | |
| SCH-50911 | CH-50911 is a selective GABA-B antagonist with IC50 value of 1.1 μM. It is developed by Schering-Plough Corporation. CH-50911 is often used in pharmacology research and it also acts as an anticonvulsant under normal conditions. Preclinical trials for Absence seizures and Cognition disorders in USA were discontinued. Uses: Absence epilepsy; cognition disorders. Synonyms: SCH-50911; SCH 50911; SCH50911; (S)-2-(5,5-dimethylmorpholin-2-yl)acetic acid. Grades: 98%. CAS No. 733717-87-8. Molecular formula: C8H15NO3. Mole weight: 173.21. | |
| SCH 527123 | A potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively. Synonyms: 2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide; SCH527123; SCH-527123; SCH 527123; MK-7123; MK7123; MK 7123; PS291822; PS-291822; PS 291822; Navarixin monohydrate; Navarixin. CAS No. 473727-83-2. Molecular formula: C21H23N3O5. Mole weight: 397.42. | |
| SCH 546738 | SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM. Synonyms: SCH546738; SCH 546738; SCH-546738; 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide. CAS No. 906805-42-3. Molecular formula: C23H31Cl2N7O. Mole weight: 492.44. | |
| SCH 563705 | SCH 563705 is a potent dual CXCR2/CXCR1 antagonist with IC50 of 1.3 and 7.3 nM, respectively. Synonyms: SCH-563705; SCH 563705; SCH563705. 3-[[3,4-dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide. CAS No. 473728-58-4. Molecular formula: C23H27N3O5. Mole weight: 425.48. | |
| Sch59498 | Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c) with antihypertensive and antiplatelet effect. Synonyms: Sch59498; Sch 59498; Sch-59498; 2-hexyl-5-methyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one; 2-Hexyl-5-methyl-7,8-propano-1,4,7beta,8beta-tetrahydro-5H-imidazo[2,1-b]purine-4-one; (6aR,9aS)-2-Hexyl-5,6a,7,8,9,9a-hexahydro-5-methylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one; DYIUKMSMAJWWAT-NEPJUHHUSA-N. CAS No. 224157-99-7. Molecular formula: C17H25N5O. Mole weight: 315.41. | |
| SCH 79797 dihydrochloride | SCH 79797 dihydrochloride is a potent and selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). SCH 79797 blocks haTRAP-induced human platelet aggregation. It also inhibits PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in vascular smooth muscle cells. Synonyms: SCH79797 dihydrochloride; SCH-79797 dihydrochloride; N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride; 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-, hydrochloride (1:2); N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine Hydrochloride (1:2). Grades: ≥99% by HPLC. CAS No. 1216720-69-2. Molecular formula: C23H25N5.2HCl. Mole weight: 444.41. | |
| SCH900776 | SCH900776, also known as MK-8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest. Synonyms: SCH-900776; SCH 900776, MK-8776; MK 8776; MK8776. Grades: >98%. CAS No. 891494-63-6. Molecular formula: C15H18BrN7. Mole weight: 376.262. | |
| SCH900776 S-isomer | SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner. Uses: Sch900776 s-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. Synonyms: SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer. Grades: >98%. CAS No. 891494-64-7. Molecular formula: C15H18BrN7. Mole weight: 376.25. | |
| SCHEMBL14831541 | SCHEMBL14831541, also called as Mutant IDH1 inhibitor, is an inhibitor of mutant IDH1 which is key enzymes found in cellular metabolism. Synonyms: Mutant IDH1 inhibitor; MDK-0084; MDK 0084; MDK0084; (4S) -3-[2-[[ (1S) -1-[4-[ (4-acetylpiperazin-1-yl) methyl]phenyl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1, 3-oxazolidin-2-oneMutant IDH1 inhibitorSCHEMBL14831541BDBM146427; BDBM 146427; BDBM-146427CS-2102; CS 2102; CS2102HY-13972; HY 13972; HY13972US8957068, 556. CAS No. 1429180-08-4. Molecular formula: C25H34N6O3. Mole weight: 466.58. | |
| SC-III3 | SC-III3 is a scopoletin derivative and has been found to induce the autophagy of hepatoma HepG2 cells so that could be significant in anticancer studies. Synonyms: SC-III3; SC III3; SCIII3; (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl) acrylamide. Grades: 98%. CAS No. 1660110-65-5. Molecular formula: C19H14ClNO5. Mole weight: 371.77. | |
| Scopine HCl | Scopine HCl is the hydrochloride of Scopine, which is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. Synonyms: Bay o 9867; Bay-o 9867; Bayo 9867; Bayo9867. Grades: >98%. CAS No. 85700-55-6. Molecular formula: C8H14ClNO2. Mole weight: 191.66. | |
| (S)-CPW 399 | (S)-CPW 399 has been found to be a subtype-selective weakly desensitising AMPA agonist. Synonyms: (S)-CPW 399; (S)-CPW399; (S)-CPW-399; (S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid. Grades: ≥98% by HPLC. CAS No. 389888-02-2. Molecular formula: C10H13N3O4. Mole weight: 239.23. | |
| SCR-1481B1 | SCR-1481B1, also known as c-Met inhibitor 2, is an effective inhibitor of MET kinase so that probably has anti-tumor activity. It is also found to be an inhibitor of VEGFR. IC50: 1.7 nM for MET kinase. Uses: Scr-1481b1 is an effective inhibitor of met kinase so that probably has anti-tumor activity. Synonyms: SCR-1481B1; SCR-1481B1; SCR-1481B1; c-Met inhibitor 2; c Met inhibitor 2. Grades: 98%. CAS No. 1174161-86-4. Molecular formula: C28H29ClF2N5O10P. Mole weight: 699.98. | |
| Scriptaid | Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. Synonyms: GCK 1026; GCK-1026; GCK1026; Scriptaid. Grades: >98%. CAS No. 287383-59-9. Molecular formula: C18H18N2O4. Mole weight: 326.35. | |
| SCS | SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 = 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors, respectively). Synonyms: Salicylidene salicylhydrazide; Chel 180. CAS No. 3232-36-8. Molecular formula: C14H12N2O3. Mole weight: 256.26. | |
| Scutellartln | Cas No. 529-53-3. | |
| SD 1008 | SD 1008 is a JAK2/STAT3 signaling pathway inhibitor that inhibits activation of STAT3, JAK2 and Src. SD 1008 induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. Synonyms: SD 1008; SD1008; SD-1008; (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester. Grades: ≥99% by HPLC. CAS No. 960201-81-4. Molecular formula: C18H19NO5. Mole weight: 329.35. | |
| SD 1029 | SD 1029 is cel-permeable and selective inhibitor of JAK2. It directly abrogates the Jak-Stat3 signaling pathway in human cancer cells expressing constitutively active Stat, suggesting its potential for cancer therapy. Synonyms: JAK2 Inhibitor III; Janus-Associated Kinase 2 Inhibitor III; SD1029; SD-1029; 9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione dihydrobromide. CAS No. 118372-34-2. Molecular formula: C25H30Cl2N2O3·2HBr. Mole weight: 639.3. | |
| SD 2590 hydrochloride | SD 2590 hydrochloride is a potent and orally bioactive MMP inhibitor (IC50 <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3, respectively) displaying 100,000-fold selectivity for MMP-2 and -13 over MMP-1. SD 2590 may be beneficial for cancer, arthritis and cardiovascular disease treatment. Synonyms: SD-2590 HCl; SD 2590 HCl; SD2590 HCl; SD-2590 Hydrochloride; SD 2590 Hydrochloride; SD2590 Hydrochloride; SC-78080; SC 78080; SC78080; N-Hydroxy-1- (2-methoxyethyl) -4-[4-[4- (trifluoromethoxy) phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 226395-93-3. Molecular formula: C22H25F3N2O7S.HCl. Mole weight: 554.96. | |
| SDM25N hydrochloride | SDM25N is a highly selective non-peptide δ receptor antagonist. Synonyms: SDM25N HCl; (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride. Grades: ≥99% by HPLC. CAS No. 342884-71-3. Molecular formula: C26H26N2O3·HCl. Mole weight: 450.96. | |
| (±)-SDZ-201 106 | (±)-SDZ-201 106 is a diphenylpiperazinylindole derivative that prolongs the open state of cardiac voltage-gated Na+ channels. It has been shown to increase net Na+ influx and the activity of reverse mode Na+/Ca2+ exchange, which leads to an increase in intracellular Ca2+, as well as to partially inhibit the Na+ pump in cardiac myocytes. Uses: Cardiotonic agents. Synonyms: DPI 201-106; 4-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy]-1H-indole-2-carbonitrile. Grades: ≥98%. CAS No. 97730-95-5. Molecular formula: C29H30N4O2. Mole weight: 466.6. | |
| SDZ 205-557 hydrochloride | SDZ 205-557 hydrochloride is a 5-HT3/5-HT4 receptor antagonist that can promote intestinal peristalsis and gastric emptying. Synonyms: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride; 2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride. Grades: ≥99% by HPLC. CAS No. 1197334-02-3. Molecular formula: C14H21ClN2O3.HCl. Mole weight: 337.25. | |
| SDZ 21009 | SDZ 21009 is a β-adrenoceptor and 5-HT1A/1B receptor antagonist (pKB/pA2 = 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors, respectively). Synonyms: Carpindolol; LM 21009; LM-21009; LM21009; SDZ 21009; SDZ21009; SDZ-21009; 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester. CAS No. 39731-05-0. Molecular formula: C19H28N2O4. Mole weight: 348.44. | |
| SDZ 220-040 | SDZ 220-040 is a potent competitive antagonist at the NMDA receptor (pKi = 8.5). Synonyms: SDZ 220-040; SDZ220-040; SDZ-220-040; (S)-α-Amino-2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid. CAS No. 174575-40-7. Molecular formula: C16H16Cl2NO6P. Mole weight: 420.19. | |
| SDZ 220-581 | SDZ 220-581 is a competitive NMDA receptor antagonist (pKi = 7.7). SDZ 220-581 was indicated a reverse effect on haloperidol-induced catalepsy in the rat model of Parkinson's disease. Synonyms: (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid. Grades: ≥98% by HPLC. CAS No. 174575-17-8. Molecular formula: C16H17ClNO5P. Mole weight: 369.74. | |
| SDZ SER 082 fumarate | SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. SDZ SER 082 fumarate inhibits [3H]-mesulergine binding to 5-HT2C receptors (pKD = 7.8), and suppresses 5-HT2B mediated responses in the rat fundus (pKB = 7.34). Synonyms: 7H-Indolo[1,7-bc][2,6]naphthyridine, 4,5,7a,8,9,10,11,11a-octahydro-10-methyl-, (7aR,11aS)-rel-, (2E)-2-butenedioate (1:1); (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine fumarate; rel-(7aR,11aS)-4,5,7a,8,9,10,11,11a-Octahydro-10-methyl-7H-indolo[1,7-bc][2,6]naphthyridine fumarate; SDZ-SER 082 fumarate. Grades: ≥95%. CAS No. 1417343-80-6. Molecular formula: C15H20N2.C4H4O4. Mole weight: 344.41. | |
| SDZ WAG 994 | SDZ WAG 994 is a potent and selective adenosine A1 receptor agonist (Ki = 23, > 10000 and 25000 nM for A1, A2A and A2B receptors, respectively). SDZ WAG 994 has been shown to lower blood pressure levels and heart rate in spontaneous hypertensive rats, and inhibit adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM). Synonyms: Adenosine, N-cyclohexyl-2'-O-methyl-; N-Cyclohexyl-2'-O-methyladenosine; SDZ-WAG 994; WAG 994. Grades: ≥99% by HPLC. CAS No. 130714-47-5. Molecular formula: C17H25N5O4. Mole weight: 363.41. | |
| SEA0400 | SEA0400 is a selective inhibitior of Na+/Ca2+ exchanger. In an MPTP mouse model of Parkinson's disease, SEA0400 prevents dopaminergic neurotoxicity. It has an obvious suppressing effect on tachyarrhythmias induced by digitalis in in vivo canine models. Synonyms: 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline 2-(4-((2,5-difluorophenyl)methoxy)phenoxy)-5-ethoxyaniline SEA 0400 SEA-0400 SEA0400. CAS No. 223104-29-8. Molecular formula: C21H19F2NO3. Mole weight: 371.38. | |
| Secukinumab | Secukinumab is a recombinant human IgG1κ monoclonal antibody that specifically binds to and inhibits interleukin (IL)-17A. Secukinumab was developed by Novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Uses: The treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Synonyms: Cosentyx. CAS No. 875356-43-7. Molecular formula: C6584H10134N1754O2042S44. Mole weight: 147944.39. | |
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