BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Rocuronium | Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker and a muscle relaxant used for modern anaesthesia during endotracheal intubation. Synonyms: Rocuronio; Zemuron; Esmeron. Grades: ≥98%. CAS No. 143558-00-3. Molecular formula: C32H53N2O4. Mole weight: 529.77. |  |
| Rodatristat ethyl | Rodatristat ethyl is a tryptophan hydroxylase 1 (TPH1) inhibitor, which reduces 5-HT levels and significantly reduces pulmonary hypertension (PAH). Synonyms: KAR5585; KAR-5585. Grades: ≥98% by HPLC. CAS No. 1673571-51-1. Molecular formula: C29H31ClF3N5O3. Mole weight: 590. | |
| Rolapitant HCl hydrate | Rolapitant, also known as SCH-619734, is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist with potential antiemetic activity. Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and late-phase CINV during the first 120 hours post-chemotherapy. Synonyms: (5S, 8S) -8- ( ( (R) -1- (3, 5-bis (trifluoromethyl) phenyl) ethoxy) methyl) -8-phenyl-1, 7-diazaspiro[4. 5]decan-2-one hydrochloride.; SCH619734 SCH-619734; SCH 619734; Rolapitant HCl; Rolapitant hydrochloride, Rolapitant, brand name: Varubi. CAS No. 914462-92-3. Molecular formula: C25H26F6N2O2.ClH.H2O. Mole weight: 554.95. | |
| Rolofylline metabolite M1-cis | Rolofylline metabolite M1-cis, an active metabolite of Rolofylline, is a potent and selective adenosine A1 receptor antagonist. Synonyms: Rolofylline metabolite M1-cis; Rolofylline metabolite M1-trans; 160943-06-6; 161167-65-3; SCHEMBL3263501; L011792; 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine-2,6-dione, cis; 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine-2,6-dione, trans. Grades: 98%. CAS No. 161167-65-3. Molecular formula: C20H28N4O3. Mole weight: 372.46. | |
| Rolofylline metabolite M1-trans | Rolofylline metabolite M1-trans, an active metabolite of Rolofylline, is a potent and selective adenosine A1 receptor antagonist. Grades: 99%. CAS No. 160943-06-6. Molecular formula: C20H28N4O3. Mole weight: 372.46. | |
| Ronacaleret | Ronacaleret is a calcium-sensing receptor (CaSR) antagonist under the development of GlaxoSmithKline. It is potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34). In Jul 2015, Phase-II for Stem cell mobilisation in USA was discontinued. In Mar 2016, Phase-I for Postmenopausal osteoporosis (In volunteers) in USA was discontinued. Uses: Postmenopausal osteoporosis; stem cell mobilisation. Synonyms: SB 751689; SB751689; SB-751689; (R)-3-(3-(3-((1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)-4,5-difluorophenyl)propanoic acid;753449-67-1 (HCl salt). Grades: 98%. CAS No. 753449-67-1. Molecular formula: C25-H31-F2-N-O4. Mole weight: 447.52. | |
| Ronopterin | Ronopterin is a potent Nitric oxide synthase inhibitor used as a neuroprotectant. Synonyms: VAS-203; VAS 203; VAS203; Ronopterin; (1R,2S)-1-[(6R)-2,4-diamino-5,6,7,8-tetrahydropteridin-6-yl]propane-1,2-diol; 4-aminotetrahydrobiopterin. Grades: >98%. CAS No. 206885-38-3. Molecular formula: C9H16N6O2. Mole weight: 240.27. | |
| Ropinirole HCl | Ropinirole a selective D-2 agonist with Ki of 29 nM. Uses: Antiparkinson agents. Synonyms: SKF-101468A; SKF 101468A; SKF101468A; AS-041164; AS 041164; AS041164. Grades: >98%. CAS No. 91374-20-8. Molecular formula: C16H24N2O·HCl. Mole weight: 296.84. | |
| Ropsacitinib | Ropsacitinib is a Janus kinase inhibitor. Synonyms: Tyk2-IN-8; PF-06826647; (1r,3r)-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile; trans-3-Cyano-1-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl]cyclobutaneacetonitrile. Grades: 98% by HPLC. CAS No. 2127109-84-4. Molecular formula: C20H17N9. Mole weight: 383.4. | |
| ROR gama modulator 1 | ROR gama modulator 1, a tetrahydropyranylmethoxy benzenesulfonamide compound, is a retinoid-related orphan receptor gamma (RORy) modulator. Synonyms: GSK2981278; GSK-2981278; GSK 2981278. N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-(oxan-4-ylmethoxy)benzenesulfonamideROR gama modulator 1SCHEMBL15352875CS-5449; CS 5449; CS5449. CAS No. 1474110-21-8. Molecular formula: C25H35NO5S. Mole weight: 461.61. | |
| ROR gamma-t-IN-1 | ROR gamma-t-IN-1, an orally bioavailable and CNS penetrant RORγt inhibitors. In vivo: it demonstrated EAE efficacy dose dependently via oral administration RORγ FRET assay: pIC50=8.4; Th17 assay: pIC50> 8.2. Synonyms: GSK805; GSK805; GSK805; ROR gamma-t-IN-1; RORγt Inverse Agonist II; N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamideROR gamma-t-IN-1SCHEMBL14746799CS-5079; HY-12776; CS 5079; HY 12776; CS5079; HY12776. CAS No. 1426802-50-7. Molecular formula: C23H18Cl2F3NO4S. Mole weight: 532.36. | |
| ROS 234 dioxalate | ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Synonyms: ROS 234 dioxalate; ROS234 dioxalate; ROS-234 dioxalate; N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate. Grades: ≥99% by HPLC. CAS No. 184576-87-2. Molecular formula: C13H15N5.2C2H2O4. Mole weight: 421.37. | |
| Rosiglitazone potassium salt | Rosiglitazone is an agonist of peroxisome proliferator-activated receptor γ (PPARγ) that binds to PPARγ and sensitizes its response to insulin. It has been indicated for the treatment of type 2 diabetes, however, its application was restricted for increasing the risk of heart failure. Synonyms: 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidin-3-ide-2,4-dione potassium salt. Grades: ≥98%. CAS No. 316371-84-3. Molecular formula: C18H18N3O3S·K. Mole weight: 395.5. | |
| Roslin-2 | Roslin-2 is a p53 reactivator that blocks the interaction of FAK and p53. It restores the transcriptional activity of p53. It reverses FAK-mediated suppression of the expression of p53-dependent p21, MDM2, and Bax in wild-type p53 HCT116 colon and MCF-7 breast cancer cells, but not in p53 mutant SW620 colon cancer cells, when used at concentrations ranging from 1 to 50 μM. Synonyms: 1-Benzyl-3,5,7-triaza-1-azoniaadamantane bromide. Grades: ≥98%. CAS No. 29574-21-8. Molecular formula: C13H19N4·Br. Mole weight: 311.2. | |
| Rosmarinic acid racemate | Rosmarinic acid racemate, the racemate of Rosmarinic acid, is found in many medicinal species of the plant Lamiaceae including Perilla frutescens. Rosmarinic acid appears to be a strong anti-inflammatory agent and is an antioxidant in several animal models. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively. Uses: Antiviral reagents. Synonyms: Benzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-; Benzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-; Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acid; Lactic acid, 3-(3,4-dihydroxyphenyl)-, 3,4-dihydroxycinnamate; α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid. Grades: ≥95%. CAS No. 537-15-5. Molecular formula: C18H16O8. Mole weight: 360.31. | |
| Rosonabant | Rosonabant is a CB1 receptor antagonist/inverse agonist originated by Esteve. It is an appetite suppressant for the treatment of obesity. But development of the drug for clinical use was apparently halted shortly after the related CB1 antagonist rimonabant was discontinued. Uses: Obesity. Synonyms: E-6776; E 6776; E6776; Rosonabant; (R)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide. Grades: 98%. CAS No. 861151-12-4. Molecular formula: C21H21Cl3N4O. Mole weight: 451.78. | |
| Rosuvastatin | Rosuvastatin, also called as ZD 4522 or Crestor, a synthetic statin, in the phase III HYDRA trial for Hypercholesterolaemia, is a competitive inhibitor of HMG-CoA reductase (IC50= 11 nM). Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid; (3R, 5S, 6E)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl]-3, 5-dihydroxy-6-heptenoic acid; (E)- (3R, 5S)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[ (methylsulfonyl) (methyl)amino]pyrimidin-5-yl]-3, 5-dihydroxyhept-6-enoic acid; AZD 4522; AZD-4522; AZD4522; X-Plended; ZD 4522. Grades: 98%. CAS No. 287714-41-4. Molecular formula: C22H28FN3O6S. Mole weight: 481.54. | |
| Rotigotine | Rotigotine is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease (PD) and Willis-Ekbom Disease. Synonyms: (S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol; 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-; (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol; 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (S)-; (-)-N 0437; (S)-(-)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol; (S)-(-)-Rotigotine; (-)-Rotigotine; (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-naphth-1-ol; Leganto; N 0923; Neupro; SPM 962. Grades: >98%. CAS No. 99755-59-6. Molecular formula: C19H25NOS. Mole weight: 315.47. | |
| Rottlerin | Rottlerin, a principal phenolic compound of the Kamala plant Mallotus philippinensis, originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Recently, it has been shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Uses: Enzyme inhibitors. Synonyms: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone. Grades: ≥98% (HPLC). CAS No. 82-08-6. Molecular formula: C30H28O8. Mole weight: 516.55. | |
| Rovatirelin | Rovatirelin, a novel synthetic agent that mimics the actions of thyrotropin-releasing hormone (TRH), binds to the human TRH receptor with higher affinity (Ki=702nM) than taltirelin (Ki=3877nM). Rovatirelin may have an orally effective therapeutic potential in patients with SCD. Synonyms: S-0373; S 0373; S0373. (4S,5S)-5-methyl-N-((S)-1-((R)-2-methylpyrrolidin-1-yl)-1-oxo-4-(thiazol-4-yl)butan-2-yl)-2-oxooxazolidine-4-carboxamide4-Oxazolidinecarboxamide, 5-methyl-N-[2-(2-methyl-1-pyrrolidinyl)-2-oxo-1-(4-thiazolylmethyl)ethyl]-2-oxo-, [4S-[4α[R*(S*)],5α]]-; UNII-9DL0X410PY; Ravatirelin [INN]; RAVATIRELIN; 9DL0X410PY; SCHEMBL14306794; (4S,5S)-5-methyl-N-((2S)-1-((2R)-2-methylpyrrolidin-1-yl)-1-oxo-3-((1,3-thiazol-4-yl)methyl)propan-2-yl)-2-oxo-1,3-oxazolidine-4-carboxamide; 204386-76-5. Grades: >98%. CAS No. 204386-76-5. Molecular formula: C16H22N4O4S. Mole weight: 366.436. | |
| Roxindole hydrochloride | Roxindole hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Synonyms: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 108050-82-4. Molecular formula: C23H26N2O.HCl. Mole weight: 382.93. | |
| RP-6530 | RP-6530, a purine derivative, has been found to be a PI3Kδ/γ inhibitor that could exhibit cytotoxicity in some lymphoma primary cells so that is significant in antineoplastic researches. It has already completed a Phase I trial for Haematological malignancies. Uses: Phosphoinositide-3 kinase inhibitors. Synonyms: RP-6530; RP6530; RP 6530; Tenalisib; (S)-2-(1-((7H-purin-6-yl)amino)propyl)-3-(3-fluorophenyl)-4H-chromen-4-one. Grades: 98%. CAS No. 1639417-53-0. Molecular formula: C23H18FN5O2. Mole weight: 415.43. | |
| RP 67580 | RP 67580 is a selective non-peptide tachykinin NK1 receptor antagonist with Ki of 2.9 nM, and shows no activity ofr NK2 and NK3 (Ki>10 uM). It exhibits antinociceptive activity in writhing and formalin paw tests in mice and gerbils. Synonyms: RP67580; RP 67580; RP-67580; (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol. Grades: ≥97% by HPLC. CAS No. 135911-02-3. Molecular formula: C29H30N2O2. Mole weight: 438.57. | |
| R-Palmitoyl-(2-methyl) ethanolamide | R-Palmitoyl-(2-methyl) ethanolamide is a metabolite of palmitoyl ethanolamide (PEA), an anti-inflammatory endogenous cannabinoid. R-Palmitoyl-(2-methyl) ethanolamide shows weak CB receptor affinity. Synonyms: RP-2ME; (R)-palmitic monoisopropanolamide; N-[(2R)-2-hydroxypropyl]hexadecanamide. Grades: ≥98%. CAS No. 179951-56-5. Molecular formula: C19H39NO2. Mole weight: 313.5. | |
| RPL-554 | RPL 554 is a potent and selective PDE3/4 inhibitor for respiratory diseases, particularly in patients with asthma. Uses: A potent and selective pde3/4 inhibitor. Synonyms: [2-[6,7-Dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-urea;UNII-3E3D8T1GIX;RPL-554; RPL-554; RPL-554; LS-193,855; LS 193,855; LS 193,855; LS193855; LS193855; LS-193855. Grades: ≥96%. CAS No. 298680-25-8. Molecular formula: C26H31N5O4. Mole weight: 477.56. | |
| (R)-PPHT hydrochloride | (R)-PPHT hydrochloride is a potent and selective D2 agonist. Uses: Dopamine agonists. Synonyms: (+/-)-PPHT hydrochloride; 71787-90-1; PPHT hydrochloride; (R)-PPHT hydrochloride; (S)-PPHT hydrochloride; 6-[2-phenylethyl(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol; hydrochloride; 159795-62-7; 161757-96-6; (+/-)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride; 6-(Phenethyl(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride; N 0434; (y)-PPHT hydrochloride; (?)-PPHT hydrochloride; EU-0101006; MLS000860001; CHEMBL1256754; DTXSID30474699; Tox21_501006; MFCD00055157; AKOS024418760; CCG-222310; LP01006; NCGC00094300-01; NCGC00261691-01; SMR000326860; NCG-C00094300-01; ( inverted question mark)-PPHT hydrochloride; FT-0757152; P-105; E98624; SR-01000075394; SR-01000075394-1; (+/-)-PPHT hydrochloride, >=98% (HPLC), solid; (+/-)-Ppht hydrochloride(N-0434)potentd2 dopamine re; ( inverted question mark)-2-(N-Phenylethyl)-N-propyl)amino-5-hydroxytetralin hydrochloride; 6-[(2-PHENYLETHYL)(PROPYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL HYDROCHLORIDE. Grades: 99%. CAS No. 161757-96-6. Molecular formula: C21H27NO.HCl. Mole weight: 345.91. | |
| RPR-200765A Mesylayte | RPR-200765A Mesylayte, a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM), could exhibit a profile of disease modifying activity in rheumatoid arthritis (RA) patients which is not observed with current drug therapies. RPR-200765A inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). Synonyms: [2-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-5-methyl-1,3-dioxan-5-yl]-morpholin-4-ylmethanone; RPR 200765A; RPR-200765 A; 218158-45-3 (RPR-200765, free base). Grades: >98%. CAS No. 218162-38-0. Molecular formula: C24H25FN4O4. Mole weight: 452.48. | |
| RPR-260243 | RPR-260243 is a selective activator of the Human Ether-ago-go-Related Gene (hERG) (IC50 = 58 nM). Uses: Selective activator of the human ether-ago-go-related gene (herg) cardiac k channel. Synonyms: RPR260243; RPR 260243; RPR-260243. (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid. Grades: ≥98%. CAS No. 668463-35-2. Molecular formula: C28H25F3N2O4. Mole weight: 510.51. | |
| RQ-00203078 | RQ-00203078 is a potent, selective and orally active TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). RQ-00203078 blocks TRPM8 activity and reduces the invasion potential of oral squamous carcinoma cell lines. Synonyms: RQ-00203078; RQ 00203078; RQ00203078. Grades: 98%. CAS No. 1254205-52-1. Molecular formula: C21H13ClF6N2O5S. Mole weight: 554.84. | |
| RQ-00311651 | RQ-00311651 is a novel T-type Ca channel inhibitor' which plays a role in neuropathic and visceral pain. RQ-00311651 notably inhibited T currents when tested at holding potentials of -65 ? -60 mV' but not -80 mV' in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also suppressed high K-induced Ca signaling in those cells. Synonyms: RQ-00311651; RQ00311651; RQ 00311651; (1S'2S)-2-(1H-benzo[d]imidazol-2-yl)-N-((R)-1-(5-(2'2'2-trifluoroethoxy)pyrazin-2-yl)ethyl)cyclopropane-1-carboxamide. CAS No. 1257116-00-9. Molecular formula: C19H18F3N5O2. Mole weight: 405.38. | |
| (R)-(-)-Rolipram | (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor. It is 2.5-fold more potent than (+)-rolipram in inhibiting membrane-bound PDE 4. Grades: >98%. CAS No. 85416-75-7. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
| (R,R)-THC | (R,R)-THC is a non-steroidal and selective estrogen receptor ligand. (R,R)-THC exhibits agonist activity at ERα receptor (Ki = 9.0 nM) and antagonist activity at ERβ receptor (Ki = 3.6 nM). (R,R)-THC also inhibits DHEA and DHEA metabolite transcriptional activity in ERβ-transfected cells. Synonyms: R,R-THC; R,R THC; R,RTHC; (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol; (R,R)-cis-Diethyl tetrahydro-2,8-chrysenediol. Grades: ≥98% by HPLC. CAS No. 138090-06-9. Molecular formula: C22H24O2. Mole weight: 320.42. | |
| RRX-001 | RRX-001 is a dinitroazetidine derivative with potential radiosensitizing activity. Upon administration, RRx-001 is able to dilate blood vessels, thereby increasing tumor blood flow and thus improving oxygenation to the tumor site. By increasing oxygen levels, these tumor cells may be more susceptible to radiation therapy. Tumor hypoxia is correlated with tumor aggressiveness, metastasis and resistance to radiotherapy. Synonyms: RRX001; RRX 001; RRx-001; ABDNAZ. CAS No. 925206-65-1. Molecular formula: C5H6BrN3O5. Mole weight: 268.022. | |
| RS 100329 hydrochloride | RS 100329 is a selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors), with 126- and 50-fold selectivity over human α1B and α1D receptors respectively. Synonyms: RS 100329 hydrochloride; RS100329 hydrochloride; RS-100329 hydrochloride; 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride. Grades: ≥99% by HPLC. CAS No. 1215654-26-4. Molecular formula: C20H25F3N4O3.HCl. Mole weight: 462.89. | |
| RS 102221 hydrochloride | RS 102221 is a selective 5-HT2C receptor antagonist (pKi = 8.7), and demonstrates nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. Synonyms: RS-102221 HCl; RS102221 HCl; RS 102221 HCl; 8-[5- (2, 4-Dimethoxy-5- (4-trifluoromethylphenylsulphonamido) phenyl-5-oxopentyl]-1, 3, 8-triazaspiro[4. 5]decane-2, 4-dione hydrochloride; N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)-benzenesulfonamide Monohydrochloride (9CI). Grades: ≥98% by HPLC. CAS No. 187397-18-8. Molecular formula: C27H31F3N4O7S.HCl. Mole weight: 649.08. | |
| RS102895 | RS102895 is a potent and specific CCR2 antagonist with binding IC50 of 360 nM. Synonyms: RS102895; RS 102895; RS-102895; 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-peperidin]-2(1H)-one. CAS No. 300815-41-2. Molecular formula: C21H21F3N2O2. Mole weight: 390.4. | |
| RS 102895 hydrochloride | RS 102895 hydrochloride is a CCR2b antagonist. Synonyms: RS 102895 hydrochloride; RS102895 hydrochloride; RS-102895 hydrochloride; 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, monohydrochloride. CAS No. 1173022-16-6. Molecular formula: C21H21F3N2O2.HCl. Mole weight: 426.86. | |
| RS 127445 | RS 127445 is a high affinity, orally bioavailable, selective serotonin antagonist of 5-HT2B receptor (pIC50= 10.4) with 1000 fold selectivity over the human recombinant 5-HT2A, 5-HT2C, 5-HT5, 5-HT6 and 5-HT7 receptors. Synonyms: 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine 2-amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine MT 500 MT-500 MT500 cpd RS 127445 RS 27354 RS-127445 RS-27354 RS127445 RS27354. Grades: >98 %. CAS No. 199864-87-4. Molecular formula: C17H17ClFN3. Mole weight: 317.79. | |
| RS 127445 hydrochloride | RS-127445 is a selective, high affinity, orally bioavailable serotonin 5-HT2B receptor antagonist (pKi = 9.5), which displays 1000-fold selectivity for 5-HT2B with good bioavailability. In isolated human cells, RS 127445 exbhites an IC50 greater than 10uM. Uses: Serotonin antagonists. Synonyms: RS 127445 hydrochloride; RS127445 hydrochloride; RS-127445 hydrochloride; 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride; 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine Monohydrochloride; MT 500 Hydrochloride. Grades: ≥98% by HPLC. CAS No. 199864-86-3. Molecular formula: C17H16FN3.HCl. Mole weight: 317.79. | |
| RS 17053 hydrochloride | RS 17053 is a novel, selective alpha 1A-adrenoceptor antagonist, which displayed high affinity for the alpha 1A-adrenoceptor (pKi and pA2 estimates of 9.1-9.9) and a 30-100-fold selectivity over the alpha 1B- and the alpha 1D-adrenoceptor subtypes (pK1 and pA2 estimates of 7.7-7.8). Synonyms: (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine) hydrochloride; RS 17053 HCl; RS 17053 HCl; RS17053; RS-17053. CAS No. 169505-93-5. Molecular formula: C24H29N2O2Cl.HCl. Mole weight: 449.42. | |
| RS 23597-190 hydrochloride | RS 23597-190 hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist with in vitro and in vivo efficacy. Synonyms: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride; RS 23597; RS-23,597-190; RS-23597-190; RS-23597; RS23597-190; RS23597. CAS No. 149719-06-2. Molecular formula: C16H23ClN2O3.HCl. Mole weight: 363.28. | |
| RS 25344 hydrochloride | RS 25344 hydrochloride is a potent and selective inhibitor of four cloned isoforms of PDE4 (A, B, C and D) and phosphorylated PDE4D (IC50= 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). It has been shown to inhibit eosinophil chemotaxis and increase progressive motility of spermatozoa in vitro. Synonyms: 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride; RS-25344 HCl; RS 25344 HCl; RS25344 HCl. Grades: ≥98% by HPLC. CAS No. 152815-28-6. Molecular formula: C19H13N5O4.HCl. Mole weight: 411.8. | |
| (RS)-3,5-DHPG | (RS)-3,5-DHPG is a group I metabotropic glutamate receptor (mGluR) agonist with selectivity for both mGlu1 and mGlu5. It is also acts as an antagonist at metabotropic glutamate receptors linked to phospholipase D. Synonyms: (RS)-3,5-Dihydroxyphenylglycine; α-Amino-3,5-dihydroxybenzeneacetic Acid; (±)-α-Amino-3,5-dihydroxybenzeneacetic Acid; 3,5-Dihydroxyphenylglycine; DL-2-(3,5-Dihydroxyphenyl)glycine. Grades: ≥99% by HPLC. CAS No. 19641-83-9. Molecular formula: C8H9NO4. Mole weight: 183.16. | |
| RS 39604 hydrochloride | RS 39604 is a high affinity and selective 5-HT4 receptor antagonist that is orally active and long-lasting in vivo, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. It is concluded that RS 39604 may be the preferable probe to use for investigating the physiological and pathophysiological role of 5-HT4 receptors in vivo. Synonyms: 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride; RS 39604; RS-39604; RS39604; RS 39604 HCl; RS 39604HCl; N-[2-[4-[3-[4-Amino-5-chloro-2-[(3,5-dimethoxyphenyl)methoxy]phenyl]-3-oxopropyl]-1-piperidinyl]ethyl]-methanesulfonamide Hydrochloride (1:1); N-[2-[4-[3-[4-Amino-5-chloro-2-[(3,5-dimethoxyphenyl)methoxy]phenyl]-3-oxopropyl]-1-piperidinyl]ethyl]-methanesulfonamide Monohydrochloride (9CI). Grades: ≥98% by HPLC. CAS No. 167710-87-4. Molecular formula: C26H36ClN3O6S.HCl. Mole weight: 590.56. | |
| (RS)-3-Hydroxyphenylglycine | (RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors. Synonyms: Amino(3-hydroxyphenyl)acetic acid; 2-Amino-2-(3-hydroxyphenyl)acetic acid. CAS No. 31932-87-3. Molecular formula: C8H9NO3. Mole weight: 167.16. | |
| RS4317 | A topically effective inhibitor of 5-lipoxygenase (5-LO). Synonyms: (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate; 6-chloro-2,3-dimethoxynaphthalene-1,4-diol diacetate; Lonapalene; RS-43179; RS 43179; RS43179. CAS No. 91431-42-4. Molecular formula: C16H15ClO6. Mole weight: 338.74. | |
| RS 504393 | RS 504393 is a highly selective CCR2 antagonist. Synonyms: RS504393; RS 504393; RS-504393; 6-methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one. CAS No. 300816-15-3. Molecular formula: C25H27N3O3. Mole weight: 417.5. | |
| RS 56812 hydrochloride | RS 56812 is a highly potent and selective 5-HT3 partial agonist (pKi= 9.6 in rat brain) with 1000-fold selectivity over a wide range of other neurotransmitter receptors. Synonyms: 1H-Indole-3-acetamide, N-1-azabicyclo[2.2.2]oct-3-yl-1-methyl-α-oxo-, monohydrochloride, (R)-; (R)-RS 56812 hydrochloride; (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 143339-12-2. Molecular formula: C18H21N3O2.HCl. Mole weight: 347.84. | |
| RS 67333 hydrochloride | RS 67333 hydrochloride is a selective, high affinity partial agonist toward 5-HT4 receptor with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Synonyms: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride; RS 67333 HCl; RS 67333; RS67333; RS-67333. Grades: ≥99% by HPLC. CAS No. 168986-60-5. Molecular formula: C19H29ClN2O2.HCl. Mole weight: 389.36. | |
| RS 67506 hydrochloride | RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. In vitro: RS 67506 acted as a potent partial agonist with respect to 5-HT at the 5-HT4 receptor regulating relaxation of the carbachol-precontracted oesophagus. Relaxant responses to RS 67506 was surmountably antagonized with apparent affinities (pKB) of 9.0. In vivo: RS 67506 induced dose-dependent potentiates heart rate of the anaesthetized micropig (ED50 5.4 pg kg-1, i.v.) with maximal increases of 47 beats min-1. Synonyms: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride; RS67506 HCl; RS67506 HCl; RS67506; RS 67506; RS-67506. CAS No. 168986-61-6. Molecular formula: C18H28ClN3O4S.HCl. Mole weight: 454.41. | |
| RS 79948 hydrochloride | RS 79948, a sulfur compound, is an α2-adrenoreceptor antagonist (Kd= 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat). It increases insulin secretion and synergistically augments insulinotropic effect of glibenclamide. Synonyms: 6H-Isoquino[2,1-g][1,6]naphthyridine, 12-(ethylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-, hydrochloride (1:1), (8aR,12aS,13aS)-; 6H-Isoquino[2,1-g][1,6]naphthyridine, 12-(ethylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-, monohydrochloride, (8aR,12aS,13aS)-; 6H-Isoquino[2,1-g][1,6]naphthyridine, 12-(ethylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-, monohydrochloride, [8aR-(8aα,12aα,13aα)]-; RS 79948-197; RS79948 hydrochloride; RS-79948 hydrochloride; (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride. Grades: ≥99% by HPLC. CAS No. 186002-54-0. Molecular formula: C19H28N2O3S.HCl. Mole weight: 400.96. | |
| (RS)-AMPA | (RS)-AMPA has been found to be a definitive agonist of the AMPA glutamatergic ionotropic receptor. Uses: Excitatory amino acid agonists. Synonyms: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. Grades: ≥99% by HPLC. CAS No. 74341-63-2. Molecular formula: C7H10N2O4. Mole weight: 186.17. | |
| (RS)-AMPA hydrobromide | The hydrobromide salt form of (RS)-AMPA, which has been found to be an agonist of the excitatory neurotransmitter L-glutamic Acid. Synonyms: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hydrobromide. Grades: ≥99% by HPLC. CAS No. 171259-81-7. Molecular formula: C7H10N2O4.HBr. Mole weight: 267.08. | |
| (RS)-APICA | (RS)-APICA has been found to be a group II metabotropic glutamate receptor antagonist and could increase extracellular glutamate concentrations and possesses unusual inverse agonist-like action. Synonyms: (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid. Grades: ≥95% by HPLC. CAS No. 170847-18-4. Molecular formula: C10H12NO5P. Mole weight: 257.18. | |
| (RS)-Butyryltimolol | (RS)-Butyryltimolol is the racemate of Butyryltimolol which is the butyryl ester of Timolol. Timolol, in the non-selective β blocker family of medication, has been shown to lower intraocular pressure in the normal and the glaucomatous rabbit eye. Synonyms: [1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-yl] butanoate. Molecular formula: C17H30N4O4S. Mole weight: 386.51. | |
| RSC-3388 | RSC-3388 is a potent inhibitor of cPLA2&alpha. It exhibited potent inhibitory effect against skin inflammation in mice. Synonyms: N-[[1-[2-(2,4-difluorobenzoyl)benzoyl]-4-[2-methylpropyl-[(2-phenylphenyl)methyl]amino]pyrrolidin-2-yl]methyl]-3-[4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl]prop-2-enamide. Grades: ≥95%. CAS No. 337307-06-9. Molecular formula: C49H44F2N4O5S. Mole weight: 839. | |
| (RS)-CPP | (RS)-CPP, a piperazin derivative, has been found to be an effective NMDA antagonist. Synonyms: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid. Grades: ≥95% by HPLC. CAS No. 100828-16-8. Molecular formula: C8H17N2O5P. Mole weight: 252.21. | |
| (R)-(+)-SLV 319 | (R)-(+)-SLV 319 is a less active enantiomer of SLV 319, which is a central cannabinoid (CB1) receptor antagonist. SLV 319 has the potential to treat neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. Synonyms: (R)-SLV 319; (R)-SLV319; (R)-SLV-319; (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide. Grades: 99%. CAS No. 656827-86-0. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.4. | |
| (RS)-MCPG | (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist. Synonyms: (RS)-α-Methyl-4-carboxyphenylglycine. Grades: ≥99% by HPLC. CAS No. 146669-29-6. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
| (RS)-MCPG Disodium Salt | (RS)-MCPG disodium salt is a non-selective group I/II metabotropic glutamate receptor antagonist. Synonyms: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt. Grades: ≥99% by HPLC. CAS No. 1303994-09-3. Molecular formula: C10H9NNa2O4. Mole weight: 253.16. | |
| (RS)-PPG | (RS)-PPG is a potent and selective group III metabotropic glutamate receptor (mGluR) agonist, with approximately 25-fold selectivity for hmGlu8. (RS)-PPG exhibits anticonvulsant and neuroprotective properties in vivo. Synonyms: (RS)-4-Phosphonophenylglycine; 2-amino-2-(4-phosphonophenyl)acetic acid. CAS No. 120667-15-4. Molecular formula: C8H10NO5P. Mole weight: 231.14. | |
| (RS)-(Tetrazol-5-yl)glycine | (RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating 20 times more active than NMDA. Synonyms: (±)-α-Amino-1H-tetrazole-5-acetic Acid; LY 285265. Grades: ≥98% by HPLC. CAS No. 138199-51-6. Molecular formula: C3H5N5O2. Mole weight: 143.1. | |
| RSV604 | RSV604 is a a novel benzodiazepine with submicromolar anti-RSV activity (EC50=0.86 uM). Uses: A putative rsv nucleoprotein(n) inhibitor in phase 2 clinical trials. Synonyms: RSV-604; A-60444; RSV604; A60444; RSV 604; A 60444; 1-(2-Fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea. Grades: ≥98%. CAS No. 676128-63-5. Molecular formula: C22H17FN4O2. Mole weight: 388.39. | |
| RSV604 racemate | RSV604 racemate is a racemic mixture of RSV604, an inhibitor of respiratory syncytial virus (RSV) replication. The racemate is less potent than the S-isomer. Synonyms: RSV604 racemate|676128-62-4|RSV604 (racemate)|1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)urea|RSV604 R enantiomer|RSV-604 racemate|RSV-604 R enantiomer|SCHEMBL641780|CHEMBL20262 6|BCB12862|BCP19832|BCP25029|HY-12993A|CS-6121|1- (2-Fluoro -phenyl ) -3- (2-oxo-5-phenyl -2, 3-di hydro-1H-benzo [e] [1, 4] diazepin-3-yl ) -urea. Grades: 98.60%. CAS No. 676128-62-4. Molecular formula: C22H17FN4O2. Mole weight: 388.39. | |
| RSV604 R enantiomer | RSV604 R enantiomer is the R-enantiomer of RSV604, an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV compared to RSV604. Synonyms: RSV604 (R enantiomer); RSV604 R enantiomer; 932108-20-8; 1-(2-fluorophenyl)-3-[(3R)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea; CHEMBL223191; HY-12993B; AKOS032944903; CS-6122; NCGC00522593-01. Grades: ≥98% (HPLC). CAS No. 932108-20-8. Molecular formula: C22H17FN4O2. Mole weight: 388.39. | |
| RSVA 405 | RSVA 405, an analog of resveratol, can significantly activate AMPK (EC50 = 1 μM) and inhibit acetyl-CoA carboxylase (ACC), one target of AMPK and a key regulator of fatty acid biogenesis, in nondifferentiated and proliferating 3T3-L1 adipocytes. It activates AMPK indirectly through a CaMKKβ-dependent mechanism. Synonyms: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid; RSVA405; RSVA 405; RSVA-405. Grades: ≥98% by HPLC. CAS No. 140405-36-3. Molecular formula: C17H20N4O2. Mole weight: 312.37. | |
| RSV-IN-1 | RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor with IC50 value of 0.11 μM. Synonyms: N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide. Grades: 99.95%. CAS No. 861139-16-4. Molecular formula: C20H21N5O4S. Mole weight: 427.48. | |
| (R)-(+)-Tolterodine | A muscarinic receptor antagonist. Used in the treatment of urinary incontinence. Uses: Urological agents. Synonyms: (+)-Tolterodine; (R)-Tolterodine; PNU-200583; PNU 200583; PNU200583. Grades: >98%. CAS No. 124937-51-5. Molecular formula: C22H31NO. Mole weight: 325.49. | |
| RU 24213 | RU 24213 is a dopamine D2 receptor agonist as well as a kappa opioid receptor antagonist. Synonyms: RU 24213; RU24213; RU-24213; 3-[2-[2-phenylethyl (propyl)amino]ethyl]phenol hydrochloride. Grades: 98%. CAS No. 67383-44-2. Molecular formula: C19H25NO.HCl. Mole weight: 319.87. | |
| RU-24969 | RU 24969 is a 5-HT1A and 5-HT1B receptors act as serotonin 1A/1B receptor agonists. Uses: Serotonin 1a receptor agonists; serotonin 1b receptor agonists. Synonyms: RU 24969 hemisuccinate; RU 24969; RU-24969; RU24969. 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;3-(1,2,3,6-Tetrahydropyridine-4-yl)-5-methoxy-1H-indole;5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate. Grades: ≥95%. CAS No. 66611-26-5. Molecular formula: C14H16N2O. Mole weight: 228.29. | |
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