BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Seglitide | Seglitide is a selective sst2 and sst5 somatostatin receptor agonist. Uses: Hormone antagonists. Synonyms: MK 678; MK-678; MK678. CAS No. 81377-02-8. Molecular formula: C44H56N8O7. Mole weight: 808.98. |  |
| SEL120-34A | SEL120-34A is an ATP-competitive and orally bioavailable inhibitor of Cyclin-dependent kinase 8 (CDK8), showing selectivity for CDK8/Cyclin C and CDK19/Cyclin C with IC50 values of 4.4 nM and 10.4 nM, respectively. Synonyms: SEL120; SEL120-34. CAS No. 1609522-33-9. Molecular formula: C15H18Br2N4. Mole weight: 414.14. | |
| Selatinib | Selatinib is a Epidermal growth factor receptor(EGFR) and ERbB-2 receptor antagonist as an analog of the quinazoline lapatinib with potential antineoplastic activity originated by Qilu Pharmaceutical. Upon administration, selatinib reversibly blocks phosphorylation of both EGFR and ErbB-2 and this leads to suppress tumor growth in EGFR/ErbB-2-overexpressing tumor cells. Treatment for lung cancer and breast cancer is in Phase I clinical trials in China. Uses: Lung cancer and breast cancer. Synonyms: UNII-6TLR8U8O3C; N- (3-chloro-4- ( (3-fluorobenzyl) oxy) phenyl) -6- (5- ( ( (2- (methylsulfinyl) ethyl) amino) methyl) furan-2-yl) quinazolin-4-amine. Grades: 98%. CAS No. 1275595-86-2. Molecular formula: C29H26ClFN4O3S. Mole weight: 565.07. | |
| Seliciclib | Seliciclib is an orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Mcl-1 belongs to the Bcl-2 family of antiapoptotic proteins and is a protein crucial to the survival of a range of tumor cell types. Synonyms: R-roscovitine. CYC202; CYC202; CYC 202; R-Roscovitine; Roscovitin; Roscovitine; Seliciclib. R-Roscovitine; Roscovitin; Roscovitine. Grades: >98%. CAS No. 186692-46-6. Molecular formula: C19H26N6O. Mole weight: 354.44. | |
| Semapimod | An investigational new drug in a clinical trial for the treatment of Crohn's Disease. It exhibits anti-inflammatory, anti-cytokine, immunomodulatory, antiviral and antimalarial activities. Synonyms: CNI-1493; CNI 1493; CNI1493; N, N'-bis [3, 5-bis [ (E) -N- (diaminomethylideneamino) -C-methylcarbonimidoyl] phenyl] decanediamide. CAS No. 352513-83-8. Molecular formula: C34H52N18O2. Mole weight: 744.91. | |
| Sematilide hydrochloride | Sematilide, also known as CK-1752, is a class III antiarrhythmic compound showing selective delayed rectifier K+ current channel blocking. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness. Uses: Anti-arrhythmia agents. Synonyms: Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monohydrochloride; Sematilide hydrochloride; Sematilide HCl; Sematilide hydrochloride; Sematilide; CK-1752A; CK1752A; CK 1752A; CK-1752; CK1752; CK 1752. CAS No. 101526-62-9. Molecular formula: C14H24ClN3O3S. Mole weight: 349.87. | |
| SEN 12333 | SEN 12333 is a brain penetrating and orally bioactive α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs) exhibiting neuroprotective property. SEN 12333 also displays functional antagonist activity at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Synonyms: WAY 317538; SEN 12333; WAY317538; SEN12333; WAY-317538; SEN-12333; N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide; 5-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)pentanamide. Grades: ≥99% by HPLC. CAS No. 874450-44-9. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| SEN 1269 | SEN 1269, under the IUPAC name 3-[[5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl]amino]phenol, is a derivative of pyrimidine that inhibits Amyloid-β (Aβ) aggregation and protects neuronal cell lines exposed to Aβ(1-42). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: SEN-1269; SEN 1269; SEN1269; 956128-01-1; 3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol; 3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol; 3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol; SCHEMBL3602388; CHEMBL2386874; CTK5H7888; DTXSID40676566; 4350AF; ZINC49582255; AKOS015850742; AK213225; HE061847; DB-080315; TC-064564; FT-0682533; A11161; I06-2365; 3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol; SEN 1269|3-[[5-[3-(Dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol. CAS No. 956128-01-1. Molecular formula: C18H18N4O2. Mole weight: 322.36. | |
| Senexin A | Senexin A is a selective Cell division protein kinase 8 (CDK8) inhibitor with IC50 value of 280 nM. Senexin A can bind to cdk19 in an ATP-competitive manner and it can also inhibit p21-induced transcription. Senexin A may inhibit the activation of tumor-promoting and pro-inflammatory secreted factors in the tumor microenvironment through preventing transcriptional activation of NFκB-induced genes. Uses: Anti-tumor. Synonyms: 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitril. Grades: 98%. CAS No. 1366002-50-7. Molecular formula: C17H14N4. Mole weight: 274.33. | |
| Seocalcitol | Seocalcitol is a synthetic vitamin D analog which is 50-200 times more potent than calcitriol at inhibiting cell proliferation and differentiation. It has been shown to promote tumor regression in vitro by inducing apoptosis. Synonyms: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol; [1R-[1α(1R*, 2E, 4E), 3aβ, 4E(1R*, 3S*, 5Z), 7aα]]-5-[[1-(6-Ethyl-6-hydroxy-1-methyl-2, 4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1, 3-Cyclohexanediol; (1R,3S,5Z)-5-[(2E)-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol. Grades: 95% by HPLC. CAS No. 134404-52-7. Molecular formula: C30H46O3. Mole weight: 454.68. | |
| SEP-363856 | SEP-363856 is a psychotropic drug with CNS activity and a unique non-D2/5-HT2A mechanism of action. Synonyms: SEP-856. CAS No. 1310426-33-5. Molecular formula: C9H13NOS. Mole weight: 183.27. | |
| SEP-363856 HCl | SEP-363856 HCl is a psychotropic drug with CNS activity and a unique non-D2/5-HT2A mechanism of action. Synonyms: SEP-363856 Hydrochloride. CAS No. 1310422-41-3. Molecular formula: C9H14ClNOS. Mole weight: 219.73. | |
| SER-601 | SER-601 is a potent and selective peripheral cannabinoid (CB2) receptor agonist with Ki value of 6.3 and 1,220 nM for CB2 and CB1 receptors, respectively. It exhibits analgesic, antidiabetic and neuroprotective effects. Synonyms: N-(Adamant-1-yl)-6-isopropyl-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide; 4-Oxo-1-pentyl-6-(propan-2-yl)-N-(tricyclo[3.3.1.1~3,7~]decan-1-yl)-1,4-dihydroquinoline-3-carboxamide. Grades: ≥98%. CAS No. 1048038-90-9. Molecular formula: C28H38N2O2. Mole weight: 434.6. | |
| Serdemetan | Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2-p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, this oncoprotein has been implicated in cancer cell proliferation and survival. Synonyms: JNJ-26854165; JNJ26854165; JNJ 26854165. Grades: >98%. CAS No. 881202-45-5. Molecular formula: C21H20N4. Mole weight: 328.42. | |
| S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea hydrochloride | EPIT is an inhibitor of nNOS, displaying 115-fold and 29-fold selectivity for nNOS versus iNOS and eNOS, respectively. Synonyms: EPIT hydrochloride; TFPI hydrochloride; EPIT HCl; TFPI HCl. Grades: ≥98%. CAS No. 163490-78-6. Molecular formula: C10H11F3N2S·HCl. Mole weight: 284.7. | |
| Setiptiline | Setiptiline is is a serotonin receptor antagonist acts as a noradrenergic and specific serotonergic antidepressant. Uses: A serotonin receptor antagonist. Synonyms: Org-8282; Org 8282; Org8282; 2,3,4,9-tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine. Grades: ≥95%. CAS No. 57262-94-9. Molecular formula: C19H19N. Mole weight: 261.36. | |
| Setiptiline maleate | Setiptiline maleate is a serotonin receptor antagonist. It is used as a tetracyclic antidepressant (TeCA) and acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It also acts as a norepinephrine reuptake inhibitor, serotonin receptor antagonist, α2-adrenergic receptor antagonist and H1 receptor inverse agonist/antihistamine. It was launched in 1989 for the treatment of depression in Japan by Mochida. It has been listed. Uses: Setiptiline maleate is used as a tetracyclic antidepressant (teca) and acts as a noradrenergic and specific serotonergic antidepressant (nassa). it also acts as a norepinephrine reuptake inhibitor, serotonin receptor antagonist, α2-adrenergic receptor antagonist and h1 receptor inverse agonist/antihistamine. Synonyms: 2,3,4,9-tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridyl maleate;Bisopool;MO-8282;MOD-20;Teciptiline maleate;1H-Dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine,2,- 3,4,9-tetrahydro-2-methyl-,(2Z)-2- butenedioate (1:1);2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine (2Z)-but-2-enedioate. Grades: >98%. CAS No. 85650-57-3. Molecular formula: C23H23NO4. Mole weight: 377.43. | |
| SF 11 | SF 11 is a selective and brain penetrating neuropeptide Y (NPY) Y2 antagonist (IC50 = 199 nM) displaying no affinity for Y1 receptor at concentrations up to 35 μM. SF 11 causes significant lethality in mice. Synonyms: SF 11; SF11; SF-11; N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide. Grades: ≥99% by HPLC. CAS No. 443292-81-7. Molecular formula: C27H30N2O2S. Mole weight: 446.6. | |
| SF2523 | SF2523 is a dual inhibitor of phosphatidylinositol 3-kinase and bromodomain-containing protein 4 with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively. In vivo SF2523 shows anti- tumor activity in xenograft studies. Synonyms: 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one; SF-2523; SF 2523; CHEMBL2322228. CAS No. 1174428-47-7. Molecular formula: C19H17NO5S. Mole weight: 371.41. | |
| SGC 0946 | SGC0946 is a potent and selective inhibitor of DOT1L, which potently and selectively kills cells containing an MLL translocation. SGC0946 inhibits DOT1L with an IC50 of 0.3nM in a radioactive enzyme assay and is over 100-fold selective for other HMTs. Synonyms: SGC-0946; SGC 0946; SGC0946. Grades: >98%. CAS No. 1561178-17-3. Molecular formula: C28H40BrN7O4. Mole weight: 618.57. | |
| SGC2085 | SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1), which has an IC50 of 50 nM for CARM1 and is over 100-fold selective for CARM1 over PRMT6. Synonyms: SGC2085; SGC-2085; SGC 2085. Grades: 99.05 %. CAS No. 1821908-48-8. Molecular formula: C19H24N2O2. Mole weight: 312.41. | |
| SGC2085 HCl | SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. Synonyms: SGC2085 HCl; SGC 2085 HCl; SGC-2085 HCl; (2S)-2-amino-N-[[4-(3, 5-dimethylphenoxy)-3-methylphenyl]methyl]propanamide; hydrochloride; 1821908-48-8 (SGC2085 free base). Grades: >98%. CAS No. 1821908-49-9. Molecular formula: C19H25ClN2O2. Mole weight: 348.87. | |
| SGC707 | SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase?3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively. Synonyms: SGC-707; SGC 707. Grades: 98%. CAS No. 1687736-54-4. Molecular formula: C16H18N4O2. Mole weight: 298.34. | |
| SGC AAK1 1 | SGC AAK1 1 is a potent and selective inhibitor of adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor. It activates Wnt signaling. Synonyms: AAK1 inhibitor 1; N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide. Grades: ≥98% by HPLC. CAS No. 2247894-32-0. Molecular formula: C21H25N5O3S. Mole weight: 427.52. | |
| SGK1 Inhibitor | SGK1 Inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2 with IC50 values of 4.8 and 2.8 nM, respectively. It prevents phosphorylation of GSK3β in U2OS cells with IC50 value of 1.4 μM. Synonyms: SGK-1 Inhibitor; N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide. Grades: ≥95%. CAS No. 1426214-51-8. Molecular formula: C17H12Cl2N6O2S. Mole weight: 435.29. | |
| (S)-Gossypol acetic acid | (S)-Gossypol acetic acid, a Bcl-2 inhibitor, could effectively induce the death of Jurkat cells in which Bcl-2 or Bcl-xL is overexpressed. IC50: 18.1μM and 22.9μM for Bcl-2 and Bcl-xL respectively. Uses: (s)-gossypol acetic acid is a bcl-2 inhibitor that could effectively induce the death of jurkat cells in which bcl-2 or bcl-xl is overexpressed. Synonyms: (S)-(+)-Gossypol acetic acid. Grades: 98%. CAS No. 1189561-66-7. Molecular formula: C32H34O10. Mole weight: 578.61. | |
| SGS 518 | SGS 518 is a selective 5-HT6 antagonist developed for the treatment of Cognitive Impairment Associated with Schizophrenia (CIAS). Uses: The treatment of cognitive impairment associated with schizophrenia (cias). Synonyms: SGS-518; LY 483518; SGS 518; SGS518; LY483518; LY-483518; 1-methyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl 2,6-difluorobenzenesulfonate. Grades: 99%. CAS No. 445441-26-9. Molecular formula: C21H22F2N2O3S. Mole weight: 420.47. | |
| SGS 518 oxalate | SGS 518 oxalate is a selective 5-HT6 antagonist used for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease. Synonyms: LY 483518; SGS 518 oxalate; LY483518; SGS518 oxalate; LY-483518; SGS-518 oxalate; 1-Methyl-3-(1-methyl-4-piperindin-4-yl)-5-hydroxy-1H-indole 2,6-difluorobenzenesulfonic acid ester oxalate. Grades: ≥98% by HPLC. CAS No. 445441-27-0. Molecular formula: C21H22F2N2O3S.C2H2O4. Mole weight: 510.51. | |
| SGX-523 | SGX523 is a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L and is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. Crystallographic study revealed that SGX523 stabilizes MET in a unique inactive conformation that is inaccessible to other protein kinases, suggesting an explanation for the selectivity. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases, including the closely related RON, even at micromolar concentrations. SGX523 inhibition of MET in vivo was associated with the dose-dependent inhibition of growth of tumor xenografts derived from human glioblastoma and lung and gastric cancers, confirming the dependence of these tumors on MET catalytic activity. Our results show that SGX523 is the most selective inhibitor of MET catalytic activity described to date and is thus a useful tool to investigate the role of MET kinase in cancer without the confounding effects of promiscuous protein kinase inhibition. Synonyms: SGX-523; SGX 523; SGX523. Grades: >98%. CAS No. 1022150-57-7. Molecular formula: C18H13N7S. Mole weight: 359.411. | |
| (S)-H-1152 dihydrochloride | (S)-H-1152 dihydrochloride is a Rho-kinase inhibitor and cell permeable inhibitor of ROCK (Ki = 1.6 nM). Uses: Rho-kinase inhibitor. Synonyms: 4-Methyl-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline dihydrochloride; 4-Methyl-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline dihydrochloride. Grades: ≥98%. CAS No. 451462-58-1. Molecular formula: C16H21N3O2S. Mole weight: 319.42. | |
| SH-1242 | SH-1242 is an analog of deguelin that binds the C-terminus of Hsp90 and inhibits its function, resulting in decreased tumor cell growth. Synonyms: SH-1242; SH 1242; SH1242. Grades: >98%. CAS No. 100359-59-9. | |
| (S)-(-)-HA-966 | (S)-(-)-HA-96 is an NMDA antagonist/partial agonist and possesses potent sedative and ataxic action. It causes disruption of striatal dopaminergic mechanisms. Synonyms: (S)-(-)-HA-966; (S)-(-)-HA 966; (S)-(-)-HA966; (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one; (3S)-3-Amino-1-hydroxypyrrolidin-2-one. Grades: ≥98% by HPLC. CAS No. 111821-58-0. Molecular formula: C4H8N2O2. Mole weight: 116.12. | |
| (S)-HexylHIBO | (S)-HexylHIBO is a Group I mGlu receptor antagonist (Kb = 30 and 61 μM at mGlu1a and mGlu5a receptors, respectively). Synonyms: (S)-hexylhomoibotenic acid; (αS)-α-Amino-4-hexyl-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid. Grades: ≥99% by HPLC. CAS No. 334887-48-8. Molecular formula: C12H20N2O4. Mole weight: 256.3. | |
| SHU 9119 | SHU 9119 is a potent antagonist at human melanocortin 3 (IC50 = 0.23 nM) and 4 receptors (IC50 = 0.06 nM), and a partial agonist at the hMC5R (IC50 = 0.09 nM). Synonyms: L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2?7)-lactam; L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, cyclic (2?7)-peptide; MBX 36; SHU-9119; SHU9119. Grades: ≥95%. CAS No. 168482-23-3. Molecular formula: C54H71N15O9. Mole weight: 1074.24. | |
| SIB 1508Y maleate | SIB 1508Y maleate is a potent neuronal nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors, respectively). SIB 1508Y has been shown to increase dopamine release and exhibit antidepressant activity. SIB 1508Y is used for the treatment of Parkinson's disease. Uses: The treatment of parkinson's disease. Synonyms: Altinicline maleate, SIB-1508Y maleate; SIB 1508Y maleate; SIB1508Y maleate; 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt; Altinicline maleate. Grades: ≥98% by HPLC. CAS No. 192231-16-6. Molecular formula: C12H14N2.C4H4O4. Mole weight: 302.33. | |
| SIB 1553A hydrochloride | SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist with selectivity for β4 subunit-containing receptors. It stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes, and acts as a cognitive enhancer potentially used for the treatment of Alzheimer's disease (AD). Uses: Potential treatment of alzheimer's disease. Synonyms: SIB1553A; SIB 1553A; SIB-1553A; (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride. Grades: ≥98% by HPLC. CAS No. 191611-89-9. Molecular formula: C13H19NOS.HCl. Mole weight: 273.82. | |
| SIB 1757 | SIB 1757 is a highly selective antagonist for the metabotropic glutamate mGlu5 receptor subtype (IC50 = 0.4 μM and > 30 μM at hmGlu5, hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8, respectively). Synonyms: SIB-1757; SIB 1757; SIB1757; 6-Methyl-2-(phenylazo)-3-pyridinol; (2E)-6-methyl-2-(phenylhydrazinylidene)pyridin-3-one. CAS No. 31993-01-8. Molecular formula: C12H11N3O. Mole weight: 213.24. | |
| SIB 1893 | SIB 1893 is a selective and noncompetitive antagonist for the metabotropic glutamate mGlu5 receptor subtype (IC50 = 0.3 μM and > 100 μM at hmGlu5, hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8, respectively). SIB 1893 also acts as a positive allosteric modulator at mGlu4 receptors. Synonyms: SIB-1893; SIB 1893; SIB1893; 2-Methyl-6-(2-phenylethenyl)pyridine; 2-methyl-6-[(E)-2-phenylethenyl]pyridine. CAS No. 6266-99-5. Molecular formula: C14H13N. Mole weight: 195.26. | |
| SID 26681509 | SID 26681509 is a potent and reversible human cathepsin L inhibitor (IC50 = 56 nM) with antimalarial activity. SID 26681509 has no inhibitory effect on cathepsin G. Synonyms: SID 26681509; SID26681509; SID-26681509; N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide. Grades: ≥97% by HPLC. CAS No. 958772-66-2. Molecular formula: C27H33N5O5S. Mole weight: 539.65. | |
| Siguazodan | Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor (IC50 = 117 nM). Siguazodan acts as a potent vasodilator. Uses: Vasodilator. Synonyms: N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine; SKF 94836; SKF-94836; SKF94836. Grades: ≥99% by HPLC. CAS No. 115344-47-3. Molecular formula: C14H16N6O. Mole weight: 284.32. | |
| Sildenafil mesylate | Cas No. 1308285-21-3. | |
| Simeprevir sodium salt | Simeprevir is an orally bioavailable inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It has been approved in combination with peginterferon-alfa and ribavirin for the treatment of HCV and HBV infections. Uses: Antiviral agents. Synonyms: TMC 435 sodium salt; TMC 435 sodium. Grades: ≥98%. CAS No. 1241946-89-3. Molecular formula: C38H47N5O7S2·xNa. Mole weight: 749.94. | |
| Sinapoyl coenzyme A | Sinapoyl coenzyme A is a fundamental metabolic intermediary utilized within the compound sector is assumes a pivotal role in the amalgamation of diverse significant compounds, encompassing sinapoylmalate, sinapic acid and sinapoylglucose. Esteemed for their antioxidative, anti-inflammatory and anticancer characteristics, these compounds used in the research of afflictions linked to oxidative stress, inflammation and cancerous manifestations. Synonyms: Sinapoyl CoA. Molecular formula: C32H44N7O20P3S. Mole weight: 971.71. | |
| Sipatrigine | Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) and a glutamate release inhibitor. Sipatrigine exhibits neuroprotective activity in rat models of cerebral ischemia. It was also reported to block Ca2+ channels. Uses: Neuroprotective agents. Synonyms: 619C; 619C-89; BW-619C-89; BW-619C89; 619 C; 619C 89; BW 619C-89; BW 619C89; 619C; 619C89; BW619C89; 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine. Grades: ≥99% by HPLC. CAS No. 130800-90-7. Molecular formula: C15H16Cl3N5. Mole weight: 372.68. | |
| Siramesine | Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in vivo. It was originally devevloped for treating depressant and it has pro-apoptotic activity on various transformed cell types. Synonyms: 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine] 1-(4-fluorophenyl)-3-(4-(4-(4-fluorophenyl)-1-piperidinyl)-1-butyl)-1H-indole Lu 28-179 Lu-28-179 Siramesine. CAS No. 147817-50-3. Molecular formula: C30H31FN2O. Mole weight: 454.58. | |
| Siramesine fumarate | Siramesine is a sigma receptor agonist with selectivity for σ2 over σ1 (IC50 = 0.19 and 17 nM, respectively). It exhibits anxiolytic and antidepressant effects. Siramesine has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. Synonyms: Lu 28-179; Siramesine fumarate salt; 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine] fumarate. Grades: ≥98%. CAS No. 163630-79-3. Molecular formula: C30H31FN2O·C4H4O4. Mole weight: 570.7. | |
| Sirtinol | Sirtinol is a SIRT inhibitor. Sirtinol significantly increased the acetylation of p53, which has been reported to be a target of SIRT1/2. Sirtinol significantly increased the G1 phase of the cell cycle. Synonyms: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; 2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide; 2-[(2-hydroxynaphthalen-1-yl)methylideneamino]-N-(1-phenylethyl)benzamide; Sir Two Inhibitor Naphthol; (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide; 2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide; 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]- N -(1-phenylethyl)benzamide; (E)-2-(((2-HYDROXYNAPHTHALEN-1-YL)METHYLENE)AMINO)-N-(1-PHENYLETHYL)BENZAMIDE; {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol. Grades: 0.98. CAS No. 410536-97-9. Molecular formula: C26H22N2O2. Mole weight: 394.474. | |
| S-Isopropylisothiourea hydrobromide | S-Isopropylisothiourea hydrobromide is the hydrobromide form of S-Isopropylisothiourea, which is a potent non-selective nitric oxide synthase (NOS) inhibitor. It has selectivity for the inducible form and is selective in vitro but may lack good in vivo efficacy due to poor cellular penetration. Its Ki values are 9.8, 22, and 37 nM using purified human iNOS, eNOS, and nNOS, respectively. It may be useful as a target for various disease models. Synonyms: Carbamimidothioic acid, 1-methylethyl ester, monohydrobromide; 2-Isopropyl-2-thiopsuedourea Hydrobromide; IPITU hydrobromide; S-Isopropylthiuronium bromide; Pseudourea, 2-isopropyl-2-thio-, hydrobromide; Isopropyl carbamimidothioate hydrobromide; S-Isopropyl-ITU hydrobromide; S-Isopropylisothiourea monohydrobromide. Grades: ≥95%. CAS No. 4269-97-0. Molecular formula: C4H11N2SBr. Mole weight: 199.11. | |
| Sitafloxacin Hydrate | Sitafloxacin is active against methicillin-resistant staphylococci, Streptococcus pneumoniae and other streptococci with reduced susceptibility to levofloxacin and other quinolones and enterococci. Synonyms: DU-6859a; DU 6859a; DU6859a. Grades: >98%. CAS No. 163253-35-8. Molecular formula: C19H20ClF2N3O4. Mole weight: 427.8. | |
| Sitaxentan sodium | Sitaxentan sodium inhibits ET-1-induced stimulation of phosphoinositide turnover with a Ki of 0.69 nM and a pA2 of 8.0. Synonyms: TBC-11251; TBC 11251; TBC11251. Grades: >98%. CAS No. 210421-74-2. Molecular formula: C18H14ClN2O6S2.Na. Mole weight: 476.89. | |
| Sitaxsentan | Sitaxsentan, also called as IPI 1040 or TBC 11251, is a potent orally bioactive ET receptor antagonist that has a long duration of action (t1/2, 5-7 hours) and is approximately 6,500-fold more selective as an antagonist for ETA compared with ETB receptors. Synonyms: N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide Sitaxentan Sitaxsentan Thelin 184036-34-8 UNII-J9QH779MEM CHEMBL282724 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-((6-methyl-1,3-ben. Grades: 95%. CAS No. 184036-34-8. Molecular formula: C18H15ClN2O6S2. Mole weight: 454.90. | |
| Sitravatinib | Sitravatinib, a new inhibitor of tyrosine kinase, has been studied to have effective in inhibiting tyrosine kinases receptors involved in driving sarcoma cell growth. It is still under a phase II trial for Non small cell lung cancer. IC50: 3980 nmol/L. Uses: Sitravatinib has been studied to have effective in inhibiting tyrosine kinases receptors involved in driving sarcoma cell growth. it is still under a phase ii trial for non small cell lung cancer. Synonyms: MGCD516; MGCD-516; MGCD 516; MG516; MG 516; MG-516; Sitravatinib. Grades: 98%. CAS No. 1123837-84-2. Molecular formula: C33H29F2N5O4S. Mole weight: 629.68. | |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
| Sivelestat sodium | Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. Synonyms: Sivelestat sodium. Grades: >98%. CAS No. 150374-95-1. Molecular formula: C20H21N2NaO7S. Mole weight: 456.44. | |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| SJ000291942 | SJ000291942 is a bone morphogenetic protein (BMP) signaling pathway activator. It activates BMP4 in C33A-2D2 human cervical cancer clone reporter cells (EC50 = ≤1 μM). Synonyms: CBMicro_010677; Oprea1_383864; SCHEMBL20620014; ZINC444226; BCP29880. Grades: 98%. CAS No. 425613-09-8. Molecular formula: C16H15FN2O4. Mole weight: 318.3. | |
| SJ 172550 | SJ 172550 is a MDMX inhibitor (EC50 = 2.3 μM), controls the biological activity of MDMX. Uses: Mdmx inhibitor. Synonyms: MDMX Inhibitor II; SJ-172550; SJ 172550; SJ172550Methyl {2-chloro-6-ethoxy-4-[(E)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]phenoxy}acetate;2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid, methyl est. Grades: ≥98 %. CAS No. 431979-47-4. Molecular formula: C22H21ClN2O5. Mole weight: 428.9. | |
| SJB2-043 | SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. It inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes and inhibited the labeling of USP1 with Ub-VS in a dose dependent manner. Synonyms: SJB2-043; SJB2043; SJB2 043. Grades: >98%. CAS No. 63388-44-3. Molecular formula: C17H9NO3. Mole weight: 275.26. | |
| SKA-121 | SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3.1). It also activates KCa2.2 and KCa2.3 channels. In blood pressure telemetry experiments, SKA-121 (100 mg/kg i.p.) significantly lowered mean arterial blood pressure in normotensive and hypertensive wild-type but not in KCa3.1-/- mice. Synonyms: SKA121; SKA 121; 5-methylnaphtho[2,1-d]oxazol-2-amine. Grades: ≥98%. CAS No. 1820708-73-3. Molecular formula: C12H10N2O. Mole weight: 198.2. | |
| SKA 31 | SKA 31 is a KCa3.1 and KCa2 channel activator (EC50 = 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2, respectively). SKA 31b has been shown to potentiate acetylcholine-induced EDHF-type dilations of mouse carotid arteries and reduce blood pressure levels in normotensive and hypertensive mice. Synonyms: SKA-31; SKA 31; SKA31; Naphtho[1,2-d]thiazol-2-ylamine; 2-Amino-beta-naphthothiazole; 2-Aminonaphthiazole. Grades: ≥99% by HPLC. CAS No. 40172-65-4. Molecular formula: C11H8N2S. Mole weight: 200.26. | |
| Skepinone-L | Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. Grades: >98%. CAS No. 1221485-83-1. Molecular formula: C24H21F2NO4. Mole weight: 425.42. | |
| (S)-Ketorolac | (S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). Synonyms: (-)-Ketorolac; (1S)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. Grades: ≥98%. CAS No. 66635-92-5. Molecular formula: C15H13NO3. Mole weight: 255.3. | |
| SKF 38393 hydrobromide | SKF 38393 hydrobromide is a selective dopamine D1-like receptor partial agonist (Ki = 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors, respectively). Synonyms: SKF 38393 hydrobromide; SKF38393 hydrobromide; SKF-38393 hydrobromide; (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide; 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide. Grades: ≥99% by HPLC. CAS No. 20012-10-6. Molecular formula: C16H17NO2.HBr. Mole weight: 336.23. | |
| SKF-38393 hydrochloride | SKF-38393, aslo known as (+/-)-SKF-38393, is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. Synonyms: SKF-38393; SKF 38393; SKF38393; SKF-38,393; SKF 38,393; SKF38,393; SKF-38393 HCl; SKF-38393 hydrochloride. Grades: 98%. CAS No. 62717-42-4. Molecular formula: C16H18ClNO2. Mole weight: 291.78. | |
| SKF 77434 hydrobromide | SKF 77434 hydrobromide is a selective dopamine D1-like receptor partial agonist (IC50 = 19.7 and 2425 nM for binding to D1-like and D2-like receptors, respectively). Synonyms: SKF 77434 hydrobromide; SKF77434 hydrobromide; SKF-77434 hydrobromide; SKF-77434 HBr; SKF 77434 HBr; SKF77434 HBr; N-Allyl-SKF38393 HBr; 2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide; N-Allyl-(+/-)-SKF-38393 hydrobromide. Grades: ≥99% by HPLC. CAS No. 300561-58-4. Molecular formula: C19H21NO2.HBr. Mole weight: 376.29. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide is a selective dopamine D1-like receptor agonist. Synonyms: SKF 81297 hydrobromide; SKF81297 hydrobromide; SKF-81297 hydrobromide; (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide; 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide. Grades: ≥98% by HPLC. CAS No. 67287-39-2. Molecular formula: C16H16ClNO2.HBr. Mole weight: 370.67. | |
| SKF81367 | SKF81367, an impurity of Cefuroxime, is a cephalosporin antibiotic. Synonyms: SKF81367; SKF 81367; SKF-81367; (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefuracetime; Cefuracetima; Cefuracetimum. CAS No. 39685-31-9. Molecular formula: C17H17N3O8S. Mole weight: 423.4. | |
| SKF-82958 hydrobromide | SKF-82958 hydrobromide is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. It has characteristic anorectic effects, hyperactivity and self-administration in animals. It also acts as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. It could induce PPD, SP and PPE mRNA expression in the intact rat striatum. Uses: Skf-82958 hydrobromide has characteristic anorectic effects, hyperactivity and self-administration in animals. it also acts as an agonist of erα with negligible activity at erβ, making it a subtype-selective estrogen. Synonyms: (±)-SKF-82958 hydrobromide; SKF 82958 hydrobromide; SKF82958 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol;Chloro-APB hydrobromide;(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide;6-Chloro-N-allyl-SKF-38393 hydrobromide. Grades: >98%. CAS No. 80751-65-1. Molecular formula: C19H21BrClNO2. Mole weight: 410.73. | |
| SKF 83566 hydrobromide | SKF 83566 hydrobromide is a potent and selective dopamine D1-like receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). SKF 83566 is also reported to be an antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Uses: Adenylyl cyclase inhibitors. Synonyms: SKF 83566 hydrobromide; SKF83566 hydrobromide; SKF-83566 hydrobromide; 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide. Grades: ≥98% by HPLC. CAS No. 108179-91-5. Molecular formula: C17H18BrNO.HBr. Mole weight: 413.15. | |
| SKF 83822 hydrobromide | SKF 83822 hydrobromide is a selective and high affinity dopamine D1-like receptor agonist (Ki = 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors, respectively). SKF 83822 stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Synonyms: SKF 83822 hydrobromide; SKF83822 hydrobromide; SKF-83822 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide; 9-chloro-5-(3-methylphenyl)-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide. Grades: ≥98% by HPLC. CAS No. 74115-10-9. Molecular formula: C20H22ClNO2.HBr. Mole weight: 424.76. | |
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