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| Product | Description | |
|---|---|---|
| RU 24969 hemisuccinate | RU 24969 hemisuccinate is a potent and selective agonist at the 5-HT1A and 5-HT1B receptors. It is centrally active following systemic administration. Synonyms: RU 24969 hemisuccinate; RU24969 hemisuccinate; RU-24969 hemisuccinate; 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate. Grades: ≥99% by HPLC. CAS No. 66611-27-6. Molecular formula: C14H16N2O.½C4H6O4. Mole weight: 287.34. |  |
| RU 28318 potassium salt | RU 28318 is a potent and selective antagonist of mineralocorticoid receptor (MR). It inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. It also decreases blood pressure in female rats following central administration in vivo. Uses: Mineralocorticoid receptor antagonists. Synonyms: Oxprenoate potassium; (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid potassium salt. Grades: ≥98% by HPLC. CAS No. 76676-34-1. Molecular formula: C25H37O4K. Mole weight: 440.66. | |
| RU 58668 | RU 58668 is a pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). It has been shown to display potent antiproliferative activity in vitro (IC50 = 0.035-0.09 nM in MCF-7 cells). Synonyms: RU 58668; RU58668; RU-58668; (11β , 17β ) -11-[4-[[5-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfonyl]pentyl]oxy]phenylestra-1, 3, 5, (10) -triene-3, 17-diol. Grades: ≥95% by HPLC. CAS No. 151555-47-4. Molecular formula: C34H43F5O5S. Mole weight: 658.76. | |
| RuBi-4AP | RuBi-4AP, a water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP), can be used as a fluorescent probe of for the treatment of cancers and other disorders. Synonyms: bis(2,2'-Bipyridine-N,N')bis(4-aminopyridine-N1) ruthenium(2+) dichloride complex; Rubi-4-aminopyridine. CAS No. 851956-02-0. Molecular formula: C30H28Cl2N8Ru. Mole weight: 672.58. | |
| RuBi-5-HT | RuBi-5-HT, a highly water-soluble caged-serotonin (5-HT) compound based on ruthenium photochemistry, is a monoamine neurotransmitter and has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907. Synonyms: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-5-hydroxytryptamine ruthenium(2+) dihexafluorophosphate complex. Molecular formula: C33H37F12N6OP3Ru. Mole weight: 955.66. | |
| RuBi-Dopa | RuBi-Dopa is RuBi-caged dopamine. RuBi-Dopa has a high uncaging efficiency and can be released with visible (blue-green) and IR light in a two-photon regime. It does not display phototoxicity at a concentration of 300 μM. Synonyms: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-(3,4-Dihydroxyphenyl)ethylamino ruthenium(2+) dichloride complex. Molecular formula: C31H36Cl2N5O2PRu. Mole weight: 713.6. | |
| RuBi-GABA | RuBi-GABA, a ruthenium-bipyridine-triphenylphosphine caged GABA, is a photolabile protecting group used for highly efficient visible light GABA uncaging. Synonyms: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex. CAS No. 1028141-88-9. Molecular formula: C42H39F6N5O2P2Ru. Mole weight: 922.8. | |
| RuBi GABA trimethylphosphine | RuBi GABA trimethylphosphine is the modified version of RuBi-GABA, which inhibits neural activity in vivo and is suitable for use as alternative for GABA agonists such as muscimol. It suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse. Synonyms: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-4-aminobutyric acid ruthenium complex sodium hexafluorophosphate salt. Molecular formula: C27H33N5O2PRu.PF6.NaPF6. Mole weight: 904.56. | |
| Ruboxistaurin | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Synonyms: 13-((dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione; Arxxant; LY 333531; LY-333531; LY333531; ruboxistaurin; ruboxistaurin mesilate hydrate. CAS No. 169939-94-0. Molecular formula: C28H28N4O3. Mole weight: 468.557. | |
| Rucaparib phosphate | Rucaparib Phosphate is a selective PARP inhibitor that suppresses the PARP1-mediated DNA repair via binding to PARP1 (Ki = <5 nM). It can be used to sensitize cancer cells to chemotherapy as an antineoplastic agent. Uses: Antineoplastic agent. Synonyms: AG-014699; PF-01367338; AG 014699; PF 01367338; AG014699; PF01367338; Rucaparib (phosphate). Grades:>98%. CAS No. 459868-92-9. Molecular formula: C19H21FN3O5P. Mole weight: 421.365. | |
| Rufloxacin hydroChloride | The hydrochloride salt form of rufloxacin, one of the fluoroquinolone antibiotics, shows broad spectrum antibioterial activity especially against gram negetive bacteria. Uses: The hydrochloride salt form of rufloxacin which shows broad spectrum antibioterial activity especially against gram negetive bacteria. Synonyms: RUFLOXACIN HCL;RUFLOXACIN HYDROCHLORIDE; 7h-pyrido (1, 2, 3-de) (1, 4)benzothiazine-6-carboxylicacid, 2, 3-dihydro-9-fluoro-1; mf-934; RUFLOXACINHYDROCHLORIDE (SUBJECTTOPATENTFREE); 2, 3-Dihydro-9-fluoro-10- (4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1, 2, 3-de][1, 4]benzo; MF 934; MF934; MF-934. Grades: 95%. CAS No. 106017-08-7. Molecular formula: C17H18FN3O3S.HCl. Mole weight: 399.87. | |
| Rupintrivir | Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). It has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction with a strictly conserved subset of amino acids in the 3C protease. It blocks processing of viral proteins, thus blocking viral replication. Uses: Antiviral agents. Synonyms: Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate; AG-7088; AG7088; AG 7088. Grades: ≥98%. CAS No. 223537-30-2. Molecular formula: C31H39FN4O7. Mole weight: 598.66. | |
| RU-SKI 201 hydrochloride | | |
| RU-SKI 43 | RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Synonyms: RU-SKI 43; RU SKI 43; RUSKI43. Grades: >98%. CAS No. 1043797-53-0. Molecular formula: C22H30N2O2S. Mole weight: 386.55. | |
| RU-SKI 43 hydrochloride | RU-SKI 43 is a potent and selective inhibitor of Hedgehog acyltransferase (HHAT). It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. Synonyms: 2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone hydrochloride. Grades: ≥98%. CAS No. 1782573-67-4. Molecular formula: C22H30N2O2S·HCl. Mole weight: 423. | |
| Ruxolitinib sulfate | Ruxolitinib sulfate (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: Ruxolitinib sulfate; 1092939-16-6; INCB018424 sulfate; beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(betaR)-1H-pyrazole-1-propanenitrile, (2Z)-2-butenedioate); SCHEMBL22127335; BCP27733; FT-0770538; 1092939-15-5; A921922; INCB018424 sulfate; INCB 018424 sulfate; INCB-018424 sulfate; 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile; sulfuric acid. Grades: >98%. CAS No. 1092939-16-6. Molecular formula: C17H20N6O4S. Mole weight: 404.44. | |
| Ruzinurad | Ruzinuradum is a urate transporter inhibitor. Synonyms: ruzinuradum. Grades: >98%. CAS No. 1638327-48-6. Molecular formula: C14H12BrNO2S. Mole weight: 338.22. | |
| RVD-Hpα | RVD-Hpα is a neuropeptide that acts as a selective CB1 receptor agonist. It has been demonstrated to increase the phosphorylation of ERK1/2 levels or release of intracellular Ca2+. CAS No. 1193362-76-3. Molecular formula: C65H105N19O17. Mole weight: 1424.66. | |
| RVT-501 | RVT-501, also referred to E6005, is a selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 2.8 nM) with potential effect to treat atopic dermatitis. Synonyms: E-6005; E6005; E6005; RVT-501; RVT501; RVT 501; lotamilast; methyl 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate; E6005; methyl 4-(((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)amino)carbonyl)benzoate. CAS No. 947620-48-6. Molecular formula: C26H24N4O5. Mole weight: 472.49. | |
| RVX-208 | RVX-208 is a potent inhibitor of BET bromodomains. RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results in increased HDL-C, but the molecular target was not previously reported. Using binding assays and X-ray crystallography, we now show that RVX-208 selectively binds to bromodomains of the BET (Bromodomain and Extra Terminal) family, competing for a site bound by the endogenous ligand, acetylated lysine, and that this accounts for its pharmacological activity. siRNA experiments further suggest that induction of ApoA-I mRNA is mediated by BET family member BRD4. These data indicate that RVX-208 increases ApoA-I production through an epigenetic mechanism and suggests that BET inhibition may be a promising new approach to the treatment of atherosclerosis. Synonyms: RVX208; RVX 208; RVX-208; Apabetalone. Grades: >98%. CAS No. 1044870-39-4. Molecular formula: C20H22N2O5. Mole weight: 370.40. | |
| RWJ 50271 | RWJ 50271 is a selective inhibitor of LFA-1/ICAM-1 mediated cell adhesion (sICAM) (IC50= 5 μM in HL60 cells). Synonyms: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide. Grades: ≥99% by HPLC. CAS No. 162112-37-0. Molecular formula: C18H17F3N4O2S. Mole weight: 410.41. | |
| RWJ 52353 | RWJ 52353 is an α2 agonist with analgesic activity (Ki= 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively). Synonyms: RWJ 52353; RWJ52353; RWJ-52353; 5-(6,7-Dihydrobenzo[b]thien-4-yl-1H-imidazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 245744-10-9. Molecular formula: C11H10N2S. Mole weight: 202.28. | |
| RWJ 52353 hydrochloride | RWJ 52353 is an agonist of α2D-adrenergic receptors (α2D-ARs) with Ki value of 1.5 nM. It also exhibits agonist activity against α2A-, α2B-, and α1-ARs with Ki values of 254, 621, and 443 nM, respectively. Synonyms: 5-(6,7-dihydro-1-benzothiophen-4-yl)-1H-imidazole hydrochloride. Grades: ≥98%. CAS No. 245744-13-2. Molecular formula: C11H10N2S·HCl. Mole weight: 238.7. | |
| RWJ 56110 | RWJ 56110 is a selective Thrombin R protease-activated receptor (PAR)-1 antagonist which exhibits no activity at PAR2, PAR3, or PAR4 subtypes. It blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Synonyms: (α S)-N-[ (1S)-3-Amino-1-[[ (phenylmethyl)amino]carbonyl]propyl]-α -[[[[1-[ (2, 6-dichlorophenyl)methyl]-3- (1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3, 4-difluoro-benzenepropanamide; RWJ-56110; RWJ 56110; RWJ56110. Grades: ≥96% by HPLC. CAS No. 252889-88-6. Molecular formula: C41H43Cl2F2N7O3.2HCl. Mole weight: 863.65. | |
| RX-3117 | RX-3117, also known as TV-1360 and fluorocyclopentenylcytosine, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway. Synonyms: RX3117; RX 3117; TV-1360; TV1360; TV 1360; fluorocyclopentenylcytosine. Grades: >98%. CAS No. 865838-26-2. Molecular formula: C10H12FN3O4. Mole weight: 257.221. | |
| RX 821002 hydrochloride | RX 821002 hydrochloride is a selective and potent α2-adrenoceptor antagonist, which exhibits selectivity for the α2D over the α2A subtypes (pKd= 9.7 and 8.2 respectively). Synonyms: RX821002 hydrochloride; RX-821002 hydrochloride; 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride; 1H-Imidazole, 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-, hydrochloride (1:1); 1H-Imidazole, 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-, monohydrochloride; 2-(2-Methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride; 2-Methoxyidazoxan monohydrochloride. Grades: ≥99% by HPLC. CAS No. 109544-45-8. Molecular formula: C12H14N2O3.HCl. Mole weight: 270.72. | |
| RY785 | RY785 is a selective inhibitor of voltage-gated potassium channels with preference for Kv2.1 (IC50 = 0.05 μM). Synonyms: HY-114608; CS-0063544; 3-(3-methoxyphenyl)-2-methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)propanamide hydrochloride. Grades: ≥98%. CAS No. 1393748-80-5. Molecular formula: C21H20N4O2S. Mole weight: 392.5. | |
| Ryuvidine | Ryuvidine, a cell-permeable dioxobenzothiazole compound, is an inhibitor of SETD8 (IC50 = 0.5 μM) that suppresses monomethylation of H4K20 in vitro.1 It less potently inhibits cyclin-dependent kinase 4 (Cdk4; IC50 = 6 μM for Cdk4/cyclin D1). Synonyms: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione; Cdk4 Inhibitor III; Cyclic-dependent Kinase 4 Inhibitor III; Ryuvidine; SPS8I2; SPS-8I2; SPS 8I2. Grades: ≥98% by HPLC. CAS No. 265312-55-8. Molecular formula: C15H12N2O2S. Mole weight: 284.33. | |
| S14161 | S14161 is an inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity. It induces apoptosis in myeloma and leukemia cell lines with IC50 value of 10 μM. Synonyms: 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene. Grades: ≥99%. CAS No. 883046-50-2. Molecular formula: C17H14FNO4. Mole weight: 315.3. | |
| S 14506 | S 14506 is a potent and selective 5-HT1A agonist. Synonyms: S-14506; S 14506; S14506; 4-fluoro-N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]benzamide. Grades: 98%. CAS No. 135722-25-7. Molecular formula: C24H26FN3O2. Mole weight: 407.48. | |
| S 14506 hydrochloride | S 14506 hydrochloride is a highly potent and selective 5-HT1A receptor full agonist (pKi = 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors, respectively). S 14506 possibly binds between the agonist binding site and the G protein interaction switch site. S 14506 exhibits anxiolytic and antihypertensive properties. Synonyms: S 14506 hydrochloride; S14506 hydrochloride; S-14506 hydrochloride; 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 286369-38-8. Molecular formula: C24H26FN3O2.HCl. Mole weight: 443.94. | |
| S16961 | S16961 is a nicotinic receptor agonist with antihyperlipidaemic property which was developed for the treatment of Hyperlipidaemia in France (PO). Synonyms: 2,3-di(hexadecanoyloxy)propyl pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2,3-bis((1-oxohexadecyl)oxy)propyl ester; S-16961; AC1L434K; S-16961-1; S 169611. CAS No. 153874-14-7. Molecular formula: C41H71NO6. Mole weight: 674.01. | |
| S 18986 | S 18986 is a positive allosteric modulator of AMPA receptors that enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices. S 18986 exhibits neuroprotective and cognitive-enhancing properties in rodent behavioral models. Synonyms: S18986; S-18986; S 18986; S18986-1; S-18986-1; S 18986-1. (3aS)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide. Grades: ≥98% by HPLC. CAS No. 175340-20-2. Molecular formula: C10H12N2O2S. Mole weight: 224.28. | |
| S-1 methanandamide | S-1 methanandamide is a CB1 receptor ligand. It inhibits electrically evoked contractions in isolated mouse vasa deferentia with an IC50 value of 230 nM. Synonyms: (R)-methanandamide; (S)-(-)-Arachidonyl-1'-Hydroxy-2'-Propylamide; (5Z,8Z,11Z,14Z)-N-[(2S)-1-hydroxypropan-2-yl]icosa-5,8,11,14-tetraenamide. Grades: ≥98%. CAS No. 157182-50-8. Molecular formula: C23H39NO2. Mole weight: 361.6. | |
| S1RA | The sigma-1 (σ1) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a potent, selective antagonist of σ1 receptors (Ki = 17 nM) that weakly binds σ2 receptors (Ki = 9,300 nM). Synonyms: S1RA; 878141-96-9; E-52862; ZW18DSD1H4; 4-(2-((5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine;4-[2-[[5-methyl-1-(2-naphthalenyl)-1h-pyrazol-3-yl]oxy]ethyl] morpholine; 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine; MORPHOLINE, 4-(2-((5-METHYL-1-(2-NAPHTHALENYL)-1H-PYRAZOL-3-YL)OXY)ETHYL)-. CAS No. 878141-96-9. Molecular formula: C20H23N3O2. Mole weight: 337.42. | |
| S1RA Hydrochloride | The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II clinical trial. IC50: 17 nM (Ki). Uses: The hydrochloride salt form of s1ra which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. Synonyms: S1RA hydrochloride; S1RA (hydrochloride); E-52862 hydrochloride; E 52862 hydrochloride; E52862 hydrochloride; SCHEMBL99116; UNII-18XZ7850YN. Grades: 98%. CAS No. 1265917-14-3. Molecular formula: C20H24ClN3O2. Mole weight: 373.88. | |
| S 24795 | S 24795 is a partial agonist of α7 nAChR with memory-enhancing activity. S 24795 improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Synonyms: S 24795; S24795; S-24795; 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide; 1-(4-bromophenyl)-2-(1-methylpyridin-1-ium-2-yl)ethanone;iodide. Grades: ≥99% by HPLC. CAS No. 304679-75-2. Molecular formula: C14H13BrINO. Mole weight: 418.07. | |
| S 25585 | S 25585 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 = 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors, respectively) without affinity for a wide range of other receptors. S 25585 significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors. Synonyms: S 25585; S-25585; S25585; 1-Benzoyl-2- [ [trans-4- [ [ [ [2-nitro-4- (trifluoromethyl) phenyl] sulfonyl] amino] methyl] cyclohexyl] carbonyl] hydrazine; N-[[4- (benzamidocarbamoyl) cyclohexyl]methyl]-2-nitro-4- (trifluoromethyl) benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 263849-50-9. Molecular formula: C22H23F3N4O6S. Mole weight: 528.5. | |
| S-2 methanandamide | S-2 methanandamide is a CB1 receptor agonist with Ki value of 26 nM. It also has weak affinity for FAAH. Synonyms: (S)-(+)-Arachidonyl-2'-Hydroxy-1'-Propylamide; (5Z,8Z,11Z,14Z)-N-(2-Hydroxypropyl)icosa-5,8,11,14-tetraenamide. Grades: ≥98%. CAS No. 157182-48-4. Molecular formula: C23H39NO2. Mole weight: 361.6. | |
| S 32212 hydrochloride | S 32212 hydrochloride is an inverse agonist of 5-HT2C receptors (pKi = 8.18 at human 5-HT2C INI, receptors), and also acts as an antagonist of human α2-adrenoceptors. S 32212 exhibits negligible affinity for α1A-adrenoceptors, histamine H1 receptors and muscarinic M1 receptors. S 32212 is identified as a potential antidepressant. Synonyms: S 32212 hydrochloride; S32212 hydrochloride; S-32212 hydrochloride; 1,2-Dihydro-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3H-benz[e]indole-3-carboxamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 847871-78-7. Molecular formula: C25H28N4O2.HCl. Mole weight: 452.98. | |
| (S)-3,5-DHPG | (S)-3,5-DHPG is a selective group I mGluR agonist used for the treatment of neuronal injury and cognitive enhancement. Uses: The treatment of neuronal injury and cognitive enhancement. Synonyms: (S)-3,5-Dihydroxyphenylglycine; (2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid. Grades: ≥98% by HPLC. CAS No. 162870-29-3. Molecular formula: C8H9NO4. Mole weight: 183.16. | |
| S 38093 | S 38093 is an inverse agonist of histamine H3 receptors. Synonyms: S-38093; S38093; 4-[3-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)propoxy]benzamide. CAS No. 862896-30-8. Molecular formula: C17H24N2O2. Mole weight: 288.38. | |
| (S)-3-Carboxy-4-hydroxyphenylglycine | (S)-3-Carboxy-4-hydroxyphenylglycine has been found to be a mixed group II mGlu agonist as well as group I metabotropic glutamate receptor antagonist. Synonyms: (S)-5-(amino(carboxy)methyl)-2-hydroxybenzoic acid. Grades: ≥98% by HPLC. CAS No. 55136-48-6. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
| (S)-3-Hydroxyphenylglycine | (S)-3-Hydroxyphenylglycine is an agonist at group I metabotropic glutamate receptors (mGlu1) with no effect at mGlu2 or mGlu4. Synonyms: (2S)-2-Amino-2-(3-hydroxyphenyl)acetic acid. Grades: ≥99% by HPLC. CAS No. 71301-82-1. Molecular formula: C8H9NO3. Mole weight: 167.16. | |
| S-49076 | This active molecular is a Axl receptor tyrosine kinase inhibitor, Proto oncogene protein c met inhibitor, Type-1, Type-2 and Type-3 fibroblast growth factor receptor antagonist originated by Servier. S49076 blocked cellular phosphorylation of MET, AXL and FGFRs and inhibited downstream signaling in vitro and in vivo. Clinical trials in Phase I/II for the treatment of Glioblastoma and Non-small cell lung cancer is on-going. Prexclinical trials for Hepatocellular carcinoma is on-going. Uses: Glioblastoma; non-small cell lung cancer. Synonyms: S-49076; S49076; S 49076; (Z)-3-((3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione;EBP 883; BMS 790052. Grades: 98%. CAS No. 1265965-22-7. Molecular formula: C22H22N4O4S. Mole weight: 438.50. | |
| (S)-4-Carboxy-3-hydroxyphenylglycine | (S)-4C3H-PG has been found to be a competitive GluR1 glutamate receptor antagonist as well as metabotropic GluR2/3 glutamate receptor agonist. Synonyms: (S)-4C3H-PG. Grades: ≥98% by HPLC. CAS No. 85148-82-9. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
| (S)-4-Carboxyphenylglycine | (S)-4-Carboxyphenylglycine has been found to be a competitive group I metabotropic glutamate receptor antagonist(S)-4-Carboxyphenylglycine has been found to be a competitive group I metabotropic glutamate receptor antagonist and selective for mGluR1. Synonyms: (S)-4CPG; (S)-4C-PG; (S)-4-Carboxyphenylglycine; (S)-4C-PG; (αS)-α-Amino-4-carboxybenzeneacetic Acid. Grades: ≥99% by HPLC. CAS No. 134052-73-6. Molecular formula: C9H9NO4. Mole weight: 195.17. | |
| S55746 | S55746 is an orally available BCL-2 specific inhibitor (Ki = 1.3 nM), displaying 70 to 400-fold selectivity for BCL-2 over BCL-XL. Synonyms: S-55746; S 55746; S 055746; BCL201. CAS No. 1448584-12-0. Molecular formula: C43H42N4O6. Mole weight: 710.82. | |
| S 5751 | S 5751 is a potent and orally bioactive antagonist of prostaglandin D2 (PGD2) receptor DP1 (Ki values 1.6 and 24.2 nM for human DP and TP receptors, respectively). S 5751 is identified as a potential treatment of allergic diseases. Uses: Potential antiallergic drug. Synonyms: S-5751; S5751; S 5751; (Z)-7-[(1S,3S,4R,5R)-4-[(5-hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: 99%. CAS No. 209268-36-0. Molecular formula: C25H31NO4S. Mole weight: 441.58. | |
| (S)-(-)-5-Fluorowillardiine | A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). Synonyms: (5S)-Fluorowillardiine; (S)-5-Fluorowillardiine. Grades: >98%. CAS No. 140187-23-1. Molecular formula: C7H8FN3O4. Mole weight: 217.15. | |
| (S)-(-)-5-Fluorowillardiine hydrochloride | (S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist. Synonyms: (5S)-Fluorowillardiine hydrochloride; (S)-5-Fluorowillardiine hydrochloride. Grades: >98%. CAS No. 1321546-70-6. Molecular formula: C7H9ClFN3O4. Mole weight: 253.62. | |
| (S)-5-Hydroxy-DPAT hydrobromide | A potent and selective dopamine (DA) D2 receptor agonist. Synonyms: Hydroxy-DPAT hydrobromide, (S)-5-; (S)-5-OH-DPAT HBr; (6S)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide. Grades: 98%. CAS No. 182210-74-8. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| (S)-(-)-5-Methoxy-2-Aminotetraline hydrochloride | (S)-(-)-5-Methoxy-2-Aminotetraline hydrochloride is a dopamine receptor agonist as a therapy for Parkinson's disease. Uses: The treatment of parkinson's disease. Synonyms: (S)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; (S)-2-amino-5-methoxytetralin hydrochloride; AK-77499; (2S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride. Grades: 99%. CAS No. 58349-17-0. Molecular formula: C11H15NO.HCl. Mole weight: 213.7. | |
| (S)-5-Methoxy-N-propyl-2-aminotetraline hydrochloride | (S)-5-Methoxy-N-propyl-2-Aminotetraline hydrochloride is a dopamine receptor agonist. Synonyms: (S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride; Aminotetraline hydrochloride, (S)-5-Methoxy-N-propyl-2-. Grades: 98%. CAS No. 93601-86-6. Molecular formula: C14H21NO.HCl. Mole weight: 255.78. | |
| S-63845 | S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP)> 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It has high affinity for the BH3-binding groove of MCL1. Study in vitro showed that S63845 could kill MCL1-dependent cancer cells; Study in vivo indicated that its potent antineoplastic activity and with an acceptable safety margin in different cancers. S63845 is promisingly to be an antineoplastic drug of various cancers. Uses: Antineoplastic drug. Synonyms: S63845; S-63845; S 63845. (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid. CAS No. 1799633-27-4. Molecular formula: C39H37ClF4N6O6S. Mole weight: 829.2646. | |
| (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one | Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer. Synonyms: (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one. Grades: > 98 %. CAS No. 154598-52-4. Molecular formula: C14H9ClF3NO2. Mole weight: 315.67. | |
| (S)-6-Hydroxybuspirone | (S)-6-Hydroxybuspirone is a major active metabolite of Buspirone. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer. Uses: 5-ht1a partial agonist. Synonyms: BMS-442606; BMS 442606; BMS442606; UNII-97L718J5KP; 97L718J5KP; ZINC22060380.8-Azaspiro(4.5)decane-7,9-dione, 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6S)-. Grades: ≥98%. CAS No. 477930-31-7. Molecular formula: C21H31N5O3. Mole weight: 401.5. | |
| (S)-6-Hydroxybuspirone hydrochloride | A major active metabolite of Buspirone and a 5-HT1A partial agonist. In comparison with the (R)-enantiomer, (S)-6-Hydroxybuspirone hydrochloride is cleared more slowly from blood and has lower affinity and selectivity for the 5HT1A receptor. Synonyms: BMS 442606 hydrochloride; BMS442606 hydrochloride; BMS-442606 hydrochloride; (10S)-10-hydroxy-8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride. Grades: 99%. CAS No. 2108875-94-9. Molecular formula: C21H31N5O3.HCl. Mole weight: 437.96. | |
| (S)-6-Hydroxy-DPAT hydrobromide | A dopamine receptor agonist. Synonyms: (6S)-6-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol; 2beta-(Dipropylamino)tetralin-6-ol; Hydroxy-DPAT hydrobromide, (S)-6-; (S)-6-OH-DPAT HBr. Grades: 98%. CAS No. 162992-70-3. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| (S)-(-)-7-Hydroxy-DPAT hydrochloride | A dopamine D3 receptor agonist that is less active compared to (R)-(+)-7-OH-DPAT. Synonyms: 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrochloride; (S)-7-OH-DPAT HCl. Grades: 99%. CAS No. 93503-07-2. Molecular formula: C16H25NO.HCl. Mole weight: 283.84. | |
| (S)-(-)-8-Hydroxy-DPAT hydrobromide | A 5-HT1A receptor partial agonist that is less active compared to R-(+)-8-hydroxy-DPAT. Synonyms: S-(-)-8-OH-DPAT HBr; Hydroxy-DPAT hydrobromide, (S)-(-)-8-; (7S)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide. Grades: 98%. CAS No. 78095-20-2. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| (S)-(-)-8-Methoxy-2-aminotetraline hydrochloride | (S)-(-)-8-Methoxy-2-Aminotetraline hydrochloride is a 5-HT1A agonist. Synonyms: Aminotetraline hydrochloride, (S)-(-)-8-Methoxy-2-; (2S)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride. Grades: 98%. CAS No. 197446-42-7. Molecular formula: C11H15NO.HCl. Mole weight: 213.7. | |
| S 9947 | S 9947 is a Kv1.5 or IKur channel blocker exhibiting a dual inhibitory effect against cloned (Kv1.5) and native (IKur) cardiac potassium current. Synonyms: S9947; S-9947; S 9947. Grades: 99%. CAS No. 332378-43-5. Molecular formula: C29H27N3O3. Mole weight: 465.54. | |
| SA 47 | SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. Synonyms: SA-47; SA 47; SA47; N-[2-[1-(6-Methyl-2-pyridinyl)-4-piperidinyl]ethyl]carbamic acid 2-(methylamino)-2-oxoethyl ester; [2-(methylamino)-2-oxoethyl] N-[2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate. Grades: ≥99% by HPLC. CAS No. 792236-07-8. Molecular formula: C17H26N4O3. Mole weight: 334.41. | |
| SA 57 | SA 57 is a potent fatty acid amide hydrolase (FAAH) inhibitor (IC50 <10 nM), and also inhibits MAGL at higher concentrations (IC50 = 410 nM and 1.4 μM, respectively). Synonyms: SA 57; SA57; SA-57; 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester; [2-(methylamino)-2-oxoethyl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate. Grades: ≥99% by HPLC. CAS No. 1346169-63-8. Molecular formula: C17H23ClN2O3. Mole weight: 338.83. | |
| Sabarubicin | Sabarubicina, a disaccharide analogue of doxorubicin, is an antineoplastic agent which can intercalate into the DNA of tumor cells and interact with topoisomerase II. Synonyms: BMS195615; MEN10755. BMS 195615; MEN 10755. BMS-195615; MEN-10755. (7S,9S)-7-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione; 4-demethoxy-7-O-(2,6-dideoxy-4-O-(2,3,6-trideoxy-3-amino-alpha-L-lyxo-hexopyranosyl)-alpha-L-lyxo-hexopyranosyl)-adriamycinone; sabarubicin. Grades: >98%. CAS No. 211100-13-9. Molecular formula: C32H37NO13. Mole weight: 643.64. | |
| Saclofen | Saclofen is a selective antagonist at GABAB receptors. Uses: Gaba antagonists. Synonyms: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid; 3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid. Grades: ≥99% by HPLC. CAS No. 125464-42-8. Molecular formula: C9H12ClNO3S. Mole weight: 249.72. | |
| Safingol | Safingol is a lyso-sphingolipid protein kinase C (PKC) inhibitor. It binds to and inhibits the regulatory phorbol-binding domain of PKC. It has the potential for the treatment of solid tumors. Synonyms: L-threo-Dihydrosphingosine; L-threo-Sphinganine; L-threo-2-Amino-1,3-octadecanediol; (2S,3S)-2-aminooctadecane-1,3-diol. Grades: ≥98%. CAS No. 15639-50-6. Molecular formula: C18H39NO2. Mole weight: 301.51. | |
| Safotibant | Safotibant is a non-peptide bradykinin B1 receptor antagonis. It is used for the topical treatment of diabetic macular oedema. It displayed binding Ki values of 0.35 and 6.5 nM at cloned human and mouse B1 receptors respectively. It also reversed acute inflammatory pain induced by carrageenan, and persistent inflammatory pain induced by CFA. It was developed by Sanofi and was in clinic phase 2 trials, but now it is terminated. Uses: Safotibant is used for the topical treatment of diabetic macular oedema. Synonyms: N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl-methylamino]ethoxy]-N-methylacetamide;LF-22-0542; LF22-0542; LF 22-0542; LF-220542; LF220542; LF 220542; Safotibant. Grades: 98%. CAS No. 633698-99-4. Molecular formula: C25H34N4O5S. Mole weight: 502.63. | |
| SAG 21k | SAG 21k is a potent, brain penetrating and orally available activator of Hedgehog signaling (EC50 = 0.4 nM). Synonyms: 3-Chloro-4, 7-difluoro-N-[[2-methoxy-5- (4-pyridinyl) phenyl]methyl]-N-trans-4- (methylamino) cyclohexyl]benzo[b]thiophene-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 946002-48-8. Molecular formula: C29H28ClF2N3O2S. Mole weight: 556.07. | |
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