BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| RITA (NSC 652287) | RITA is an inhibitor of p53-HDM-2 interaction, which binds to p53dN with a Kd of 1.5 nM, and also induces DNA-DNA cross-links. Synonyms: NSC-652287; NSC652287; NSC 652287; RITA. CAS No. 213261-59-7. Molecular formula: C14H12O3S2. Mole weight: 292.367. |  |
| Ritanserin | Ritanserin is a potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM) with high selectivity for 5-HT2A over 5-HT1 receptors (IC50s = 0.9 nM and >1000 nM, respectively). Synonyms: 6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one; Ritanserin; R-55667; R 55667; R55667. Grades: ≥99% by HPLC. CAS No. 87051-43-2. Molecular formula: C27H25F2N3OS. Mole weight: 477.57. | |
| Ritodrine Hydrochloride | Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.Ritodrine (discontinued preparation: Yutopar) is a tocolytic drug, used to stop premature labor. This drug has been removed from the US market, according to FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt, ritodrine hydrochloride. Uses: Tocolytic agents. Synonyms: NSC 291565; NSC291565; NSC-291565. Grades: >98%. CAS No. 23239-51-2. Molecular formula: C17H21NO3.HCl. Mole weight: 323.81. | |
| Rivastigmine tartrate | Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease. Synonyms: ENA 713; ENA713; ENA-713. Grades: >98%. CAS No. 129101-54-8. Molecular formula: C14H22N2O2.C4H6O6. Mole weight: 400.42. | |
| Rivenprost | Rivenprost is a potent and selective agonist for the EP4 receptor. It is selective for EP4 receptor over EP3, EP2, and EP1 receptors with Ki values of 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively. It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants. Synonyms: ONO-4819; Methyl 4- [2- [ (1R, 2R, 3R) -3-hydroxy-2- [ (E, 3S) -3-hydroxy-4- [3- (methoxymethyl) phenyl] but-1-enyl] -5-oxocyclopentyl] ethylsulfanyl] butanoate. Grades: ≥98%. CAS No. 256382-08-8. Molecular formula: C24H34O6S. Mole weight: 450.6. | |
| Riviciclib HCl | Riviciclib, also known as P276-00, is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Synonyms: 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride; P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl. CAS No. 920113-03-7. Molecular formula: C21H21Cl2NO5. Mole weight: 438.3. | |
| RJR-2403 | At concentrations up to 1 mM, RJR-2403 does not significantly activate nAChRs in PC12 cells, muscle type nAChRs or muscarinic receptors. Dose-response curves for agonist-induced ileum contraction indicate that RJR-2403 is less than one-tenth as potent as nicotine with greatly reduced efficacy. RJR-2403 does not antagonize nicotine-stimulated muscle or ganglionic nAChR function (IC50 > 1 mM). Chronic exposure of M10 cells to RJR-2403 (10 microM) results in an up-regulation of high-affinity nAChRs phenomenologically similar to that seen with nicotine. RJR-2403 significantly improved passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats with ibotenic acid lesions of the forebrain cholinergic projection system in an 8-arm radial maze paradigm. By comparison, RJR-2403 was 15 to 30-fold less potent than nicotine in decreasing body temperature, respiration, Y-maze rears and crosses and acoustic startle response. Metanicotine was about 5-fold less potent than nicotine in the tail-flick test after s.c administration, but slightly more potent after central administration. Synonyms: Rivanicline; Metanicotine; RJR-2403; RJR 2403; RJR2403; Metanicotine; Rivanicline oxalate. Grades: >98%. CAS No. 15585-43-0. Molecular formula: C10H14N2. Mole weight: 162.23. | |
| RJR-2403 oxalate | A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo. Synonyms: (E)-Metanicotine oxalate; Rivanicline oxalate; RJR 2403 oxalate; RJR2403 oxalate; RJR-2403 oxalate. Grades: >98%. CAS No. 220662-95-3. Molecular formula: C12H16N2O4. Mole weight: 252.27. | |
| RJR 2429 dihydrochloride | RJR 2429, a heterocyclic substituted pyridine compound, is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 ± 17 nM;Emax = 110 ± 09% vs.nicotine). It induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Synonyms: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride; RJR-2429 2HCL; RJR-2429 dihydrochloride; RJR2429 dihydrochloride; RJR 2429 dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1021418-53-0. Molecular formula: C12H16N2.2HCl. Mole weight: 261.19. | |
| RK-20448 | RK-20448 is the cis-isomer of A-419259. RK-20448 acts as an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2 (IC50s = 0.24, 1.19, 10.74, and 5.85 μM, respectively). Synonyms: 7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98%. CAS No. 479501-40-1. Molecular formula: C29H34N6O. Mole weight: 482.62. | |
| RK-24466 | RK-24466 is a cell-permeable and ATP-competitive inhibitor of lymphocyte-speci?c protein tyrosine kinase (Lck). It was shown to suppress cell receptor-stimulated IL-2 production in mice. Synonyms: Lck Inhibitor?; 4-Amino-5-(4-Phenoxyphenyl)-7H-Pyrrolo[2,3-D]pyrimidin-7-yl-Cyclopentane; 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine. Grades: ≥95%. CAS No. 213743-31-8. Molecular formula: C23H22N4O. Mole weight: 370.5. | |
| RKI 1447 dihydrochloride | RKI 1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 values of 14.5 nM and 6.2 nM, respectively. It suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM). Synonyms: RKI 1447 dihydrochloride; RKI1447 dihydrochloride; RKI-1447 dihydrochloride; N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride; RKI 1447 2Hcl. Grades: ≥99% by HPLC. Molecular formula: C16H14N4O2S.2HCl. Mole weight: 399.29. | |
| (R)-(-)-LY 426965 dihydrochloride | (R)-(-)-LY 426965 dihydrochloride is a selective 5-HT1A antagonist that is less active than its opposite (S)-(+)-enantiomer LY 426965. Synonyms: (R)-(-)-LY 426965 dihydrochloride; (R)-(-)-LY426965 dihydrochloride; (R)-(-)-LY-426965 dihydrochloride; (2R)-1-cyclohexyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methyl-2-phenylbutan-1-one dihydrochloride. Grades: 99%. CAS No. 228418-85-7. Molecular formula: C28H38N2O2.2HCl. Mole weight: 507.54. | |
| (R)-Midodrine hydrochloride | Midodrine is a Alpha adrenergic receptor under the development of Shire for the treatment of dysautonomia and orthostatic hypotension. In August 2010, the FDA proposed withdrawing this approval because Shire has failed to complete required studies after the medicine reached the market. In September 2011, Shire announced that it was continuing the process to work with the FDA towards a final approval of the drug. Uses: Dysautonomia and orthostatic hypotension. Synonyms: Amatine, ProAmatine, Gutron, ST-1085; ST 1085; ST1085; 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide; 3092-17-9(hydrochloride). Grades: 98%. CAS No. 133163-28-7. Molecular formula: C12H19ClN2O4. Mole weight: 290.74. | |
| RN-1734 | RN-1734 is selective antagonist of the TRPV4 channel. It completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50values for all three species with IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively. It is selective for TRPV4 in a TRP selectivity panel, thus is used as a valuable pharmacological probe for TRPV4 studies. It blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo. Uses: Rn-1734 is used as a valuable pharmacological probe for trpv4 studies. Synonyms: RN1734; RN 1734; RN-1734; 2, 4-Dichloro-N-isopropyl-N- (2-isopropylaminoethyl) benzenesulfonamide; 2, 4-Dichloro-N-propan-2-yl-N-[2- (propan-2-ylamino) ethyl]benzenesulfonamide; 2, 4-Dichloro-N- (1-methylethyl) -N-[2-[ (1-methylethyl) amino]ethyl]benzenesulfonamide. Grades: 95%. CAS No. 946387-07-1. Molecular formula: C14H22Cl2N2O2S. Mole weight: 353.31. | |
| RN 1747 | RN 1747, a selective TRPV4 agonist (EC50= 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively), represents the first drug-like TRPV4 antagonist with selectivity over closely related TRP channels. The activities of these compounds were characterized using two different systems: Ca2+ influx assay with human, mouse and rat TRPV4-expressing HEK293 cells and electrophysiology in hTRPV4-transfected Xenopus oocytes. Importantly, RN-1734 antagonized both ligand-gated activation and hypotonicity-induced opening of TRPV4 in both types of assay. Synonyms: Piperazine, 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-; 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)piperazine; RN1747; RN-1747; 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine. Grades: ≥95%. CAS No. 1024448-59-6. Molecular formula: C17H18ClN3O4S. Mole weight: 395.87. | |
| RN-18 | RN-18, a selective inhibitor of virion infectivity factor (Vif) APOBEC interactions and HIV-1 replication (IC50= 6 μM in nonpermissive H9 cells), antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. Synonyms: RN-18; RN 18; RN18; N-(2-methoxyphenyl)-2-(4-nitrophenyl)sulfanylbenzamide; 2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide; AC1LQ42R; Ambcb6776439. Grades: 99.37%. CAS No. 431980-38-0. Molecular formula: C20H16N2O4S. Mole weight: 380.42. | |
| RN486 | RN486 is a reversible Bruton's tyrosine kinase (Btk) inhibitor with IC50 value of 4.0 nM. Synonyms: RN486; RN-486; RN 486. Grades: >98%. CAS No. 1242156-23-5. Molecular formula: C35H35FN6O3. Mole weight: 606.69. | |
| RN983 | RN983 is a selective BTK enzyme inhibitor. It inhibits IgG production in B-cells with an IC50 value of 2.5?±?0.7?nM and PGD2 production from mast cells with an IC50 value of 8.3?±?1.1?nM. RN983 showed similar activities in the allergic mouse model of asthma. RN983 may be effective as a stand-alone asthma therapy or used in combination with inhaled steroids and β-agonists in severe asthmatics. Uses: Asthma. Synonyms: RN983; RN-983; RN 983. 6-(tert-butyl)-8-fluoro-2-(3-(hydroxymethyl)-4-(1-methyl-5-((5-(1-methylpiperidin-4-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydropyridazin-3-yl)pyridin-2-yl)phthalazin-1(2H)-one. Grades: 98%. CAS No. 1423129-83-2. Molecular formula: C34H37FN8O3. Mole weight: 624.72. | |
| RN 9893 hydrochloride | RN 9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4 (IC50= 320, 420 and 660 nM for mouse, human and rat channels, respectively), with >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Synonyms: N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride; RN9893 HCl; RN-9893 HCl; RN 9893 HCl; RN9893 Hydrochloride; RN-9893 Hydrochloride; RN 9893 Hydrochloride. Grades: ≥99% by HPLC. CAS No. 1803003-68-0. Molecular formula: C21H23F3N4O5S.HCl. Mole weight: 536.95. | |
| R(-)-N-Ethylnorapomorphine hydrochloride | R(-)-N-Ethylnorapomorphine hydrochloride is a dopamine D2 receptor agonist. Synonyms: (6aR)-6-ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide. Grades: 99%. CAS No. 123240-93-7. Molecular formula: C18H19NO2.HBr. Mole weight: 362.26. | |
| (R)-(-)-Niguldipine Hydrochloride | (R)-(-)-Niguldipine Hydrochloride, the less active enantiomer of Niguldipine Hydrochloride, is an L-type calcium channel protein inhibitor and α1A-AR (α1A-adrenoceptor) antagonist. Synonyms: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester, monohydrochloride, (4R)-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester, monohydrochloride, (R)-; (-)-Niguldipine hydrochloride; (R)-Niguldipine hydrochloride; B 8509-035; B 859-35; BY 935; Dexniguldipine hydrochloride. Grades: ≥95%. CAS No. 113145-70-3. Molecular formula: C36H39N3O6.HCl. Mole weight: 646.18. | |
| R(-)-Norapomorphine hydrobromide | R(-)-Norapomorphine hydrobromide is a potent dopamine receptor agonist. Synonyms: (R)-5,6,6a,7-Tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide. Grades: 98%. CAS No. 115017-61-3. Molecular formula: C16H15NO2.HBr. Mole weight: 334.21. | |
| (R)-(+)-Nor Verapamil Hydrochloride | This active molecular is a chiral metabolite of Verapamil which is a calcium channel blocker applicated in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches recently. Uses: Chiral metabolite of verapamil. Synonyms: (αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-benzeneacetonitrile Hydrochloride; (R)-Norverapamil Hydrochloride;Agi-003; Agi 003; Agi003. Grades: 98%. CAS No. 123932-43-4. Molecular formula: C26H36N2O4. Mole weight: 447.04. | |
| RNPA1000 | RNPA1000 isa RnpA inhibitor as an attractive antimicrobial development candidate. Uses: Rnpa inhibitor. Synonyms: RNPA1000; RNPA-1000; RNPA 1000; 4-[3-[(E)-3-(3-bromoanilino)-2-cyano-3-oxoprop-1-enyl]-2,5-dimethylpyrrol-1-yl]benzoic acid. Grades: ≥98%. CAS No. 359600-10-5. Molecular formula: C23H18BrN3O3. Mole weight: 464.3. | |
| R(-)-N-Propylnorapomorphine hydrobromide | A potent and selective dopamine D2 receptor agonist. Grades: 99%. CAS No. 85199-01-5. Molecular formula: C19H21NO2.HBr. Mole weight: 376.29. | |
| Ro 01-6128 | Ro 01-6128 is a positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM). Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM. Synonyms: (Diphenylacetyl)-carbamic acid ethy ester; Ro01-6128; Ro-01-6128; Ro 01-6128. Grades: ≥98% by HPLC. CAS No. 302841-86-7. Molecular formula: C17H17NO3. Mole weight: 283.32. | |
| Ro 0437626 | Ro 0437626, a benzimidazole-2-carboxamide derivative, is a selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) with >30-fold selectivity over the P2X 2 , P2X 3 and P2X 2/3 receptors. Synonyms: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide; RO1166446/008; RO116 6446/008; RO116-6446/008; RO116-6446008; RO-0437626; RO 0437626; RO0437626. Grades: ≥98% by HPLC. CAS No. 134362-79-1. Molecular formula: C27H35N5O4S. Mole weight: 525.66. | |
| Ro 04-5595 | Ro 04-5595 hydrochloride is a selective NMDA receptor inhibitor (Ki = 31 nM). Synonyms: 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride. Grades: ≥98% by HPLC. CAS No. 64047-73-0. Molecular formula: C19H22ClNO2.HCl. Mole weight: 368.3. | |
| Ro 04-6790 | Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi= 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Some studies indicate that Ro 04-6790 attenuates behavioural effects related to the hypofunction of the NMDA receptor suggesting that this compound might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. Synonyms: Ro 04-6790; Ro04-6790; Ro-04-6790. 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide; Ro 04-6790; Ro04-6790; Ro-04-6790. Grades: ≥98% by HPLC. CAS No. 202466-68-0. Molecular formula: C12H16N6O2S. Mole weight: 308.36. | |
| RO 04-6790 hydrochloride | RO 04-6790 hydrochloride is a potent and selective serotonin 5-HT6 receptor antagonist. Synonyms: RO 04-6790 hydrochloride; RO-04-6790 hydrochloride; RO046790 hydrochloride; RO 046790 hydrochloride; 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide Dihydrobromide. Grades: 98%. CAS No. 1197333-95-1. Molecular formula: C12H16N6O2S.2HCl. Mole weight: 381.28. | |
| RO10-5824 | RO10-5824 is a D4-selective partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM), and is approximately 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors. RO10-5824 is a potent candidate for the management of cocaine use disorders. Synonyms: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine; RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824. CAS No. 189744-46-5. Molecular formula: C17H20N4. Mole weight: 280.37. | |
| Ro 10-5824 dihydrochloride | Ro 10-5824, a D4R partial agonist, might have beneficial effects on attention and impulsivity by modulating baseline gamma activity in the frontal cortex. Synonyms: Ro 10-5824 dihydrochloride; Ro10-5824 dihydrochloride; Ro-10-5824 dihydrochloride; 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;dihydrochloride; Ro 10-5824 (dihydrochloride). CAS No. 189744-94-3. Molecular formula: C17H22Cl2N4. Mole weight: 353.29. | |
| Ro 106-9920 | Ro 106-9920, a cell-permeable tetrazolopyridazine-phenylsulfoxide compound, is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6 (IC50 < 1 μM in human peripheral blood mononuclear cells). Synonyms: Ro 106-9920; Ro106-9920; Ro-106-9920; 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine. Grades: ≥99% by HPLC. CAS No. 62645-28-7. Molecular formula: C10H7N5OS. Mole weight: 245.26. | |
| Ro 15-4513 | Ro 15-4513, a high affinity benzodiazepine ligand, acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Uses: Affinity labels. Synonyms: Ro 15-4513; Ro 154513; Ro-15-4513; 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester. Grades: ≥98% by HPLC. CAS No. 91917-65-6. Molecular formula: C15H14N6O3. Mole weight: 326.31. | |
| Ro 19-4603 | Ro 19-4603 is a novel potent partial inverse agonist of benzodiazepine (BZ) receptors. Ro19-4603 binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Synonyms: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester; Ro19-4603; Ro 19-4603; Ro-19-4603. Grades: ≥99% by HPLC. CAS No. 99632-94-7. Molecular formula: C15H17N3O3S. Mole weight: 319.38. | |
| Ro 25-6981 | Ro 25-6981, structurally related to ifenprodil and with no affinity for the known binding sites of non-competitive antagonists such as phencyclidine or MK-801, is a selective and activity-dependent blocker of NMDA receptors containing the NR2B subunit. Synonyms: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;(Z)-but-2-enedioic acid Ro 25-6981 (Maleate) Ro 25-6981 maleate 169274-78-6 1312991-76-6 SCHEMBL16669133 C22H29NO2.C4H4O4 4008AH 4-((1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methyl. Grades: >98 %. CAS No. 169274-78-6. Molecular formula: C22H29NO2.C4H4O4. Mole weight: 455.54. | |
| RO 25-6981 hydrochloride | RO 25-6981 hydrochloride is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit. Synonyms: Ro 256981 HCl; Ro 25 6981 HCl; Ro 25-6981 HCl; 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol hydrochloride. Grades: 99%. CAS No. 919289-58-0. Molecular formula: C22H29NO2.HCl. Mole weight: 375.93. | |
| Ro 25-6981 Maleate | The Maleate salt form of Ro 25-6981 which is a NMDA receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. IC50: 9 nM. Uses: The maleate salt form of ro 25-6981 which is a nmda receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. Synonyms: Ro 25-6981 Maleate; Ro25-6981 Maleate; Ro-25-6981 Maleate; αR-(4-hydroxyphenyl)-βS-methyl-4-(phenylmethyl)-1-piperidinepropanol, 2Z-butenedioate. Grades: 98%. CAS No. 1312991-76-6. Molecular formula: C26H33NO6. Mole weight: 455.54. | |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate is a competitive inhibitor of IL-2/ IL-2Rα receptor interaction. Synonyms: methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate; 2,2,2-trifluoroacetic acid; Ro26-4550; Ro-26-4550 trifluoroacetate; Ro 26-4550 trifluoroacetate; Ro264550 trifluoroacetate. CAS No. 1217448-66-2. Molecular formula: C26H30N4O3.CF3CO2H. Mole weight: 560.57. | |
| RO 28-0450 | RO 28-0450 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO-28-1674; RO 28 1674; RO-28 1674; RO281674; 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide. Grades: 98%. CAS No. 300352-96-9. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO 28-1674 | RO 28-1674 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO 28 1674; RO-28-1674; RO-28 1674; RO281674; (S)-3-cyclopentyl-2-(4-(methylsulfonyl)phenyl)-N-(thiazol-2-yl)propanamide. Grades: 99%. CAS No. 599164-57-5. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| Ro 28-1675 | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO-3 | RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively). RO-3 is used in a combination of compounds to develop a substance used for alleviating pain and skin disorders. Synonyms: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine; RO-3; RO 3; RO3. Grades: ≥98% by HPLC. CAS No. 1026582-88-6. Molecular formula: C16H22N4O2. Mole weight: 302.37. | |
| RO31-8220 | Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate or diacylglycerols by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells. Uses: Enzyme inhibitors. Synonyms: RO31-8220; RO 31-8220; RO-31-8220; RO318220. Grades: 0.98. CAS No. 125314-64-9. Molecular formula: C25H23N5O2S. Mole weight: 457.552. | |
| Ro 31-8220 Mesylate | Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-&epsilon. Synonyms: RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate; Bisindolylmaleimide IX; BIM IX.Bisindolylmaleimide IX Mesylate. Grades: >98%. CAS No. 138489-18-6. Molecular formula: C25H23N5O2S.CH4O3S. Mole weight: 553.65. | |
| Ro 32-0432 hydrochloride | Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold greater selectivity for PKC-βI over PKC- &epsilon (IC50 = 108 nM). Synonyms: Ro 32-0432; Ro 320432; Ro-32-0432. 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; RO 32-0432 HCL; RO 32-0432 HYDROCHLORIDE; BISINDOLYLMALEIMIDE XI, HCL; BISINDOLYLMALEIMIDE XI HYDROCHLORIDE; BISINDOLYLMALEIMIDE XL, HCL; BISINDOYLMALEIMIDE XI HYDROCHLORIDE. Grades: ≥99% by HPLC. CAS No. 151342-35-7. Molecular formula: C28H28N4O2.HCl. Mole weight: 489.01. | |
| Ro 32-3555 | Ro 32-3555 is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). It inhibits both the cartilage and bone changes in this mouse model of OA, and thus shows great potential as a treatment of OA in humans. Synonyms: Ro-32-3555; Ro 32 3555; Ro323555; (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide; Cipemastat; Ro32-3555; 190648-49-8; GFUITADOEPNRML-SJORKVTESA-N; UNII-02HQ4TYQ60; Trocade. Grades: ≥97% by HPLC. CAS No. 190648-49-8. Molecular formula: C22H36N4O5. Mole weight: 436.55. | |
| RO-3306 | RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis. Synonyms: RO-3306; RO 3306; RO3306. Grades: 0.98. CAS No. 872573-93-8. Molecular formula: C18H13N3OS2. Mole weight: 351.44. | |
| Ro 41-1049 hydrochloride | The hydrochloride salt form of Ro 41-1049 which is a MAO-A inhibitor and probably could be used in the study of Parkinson's disease. Uses: The hydrochloride salt form of ro 41-1049 which is a mao-a inhibitor and probably could be used in the study of parkinson's disease. Synonyms: RO-41-1049 hydrochloride; RO 41-1049 hydrochloride; RO-41-1049 HCl; UNII-19Z49HUF4G; N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide hydrochloride; Ro 41-1049 (hydrochloride); AC1NSKEH; R107_SIGMA. Grades: 98%. CAS No. 127917-66-2. Molecular formula: C12H13ClFN3OS. Mole weight: 301.77. | |
| RO462005 | RO462005 is an endothelin receptor selective agonist. Uses: Endothelin receptor antagonists. Synonyms: RO462005; RO-462005; RO 462005; Ro-46-2005; Ro 46-2005; Ro46-2005. Grades: 98%. CAS No. 150725-87-4. Molecular formula: C23H27N3O6S. Mole weight: 473.54. | |
| RO4987655 | RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: RO4987655; RO-4987655; RO 4987655; CH4987655; CH-4987655; CH 4987655. CAS No. 874101-00-5. Molecular formula: C20H19F3IN3O5. Mole weight: 565.288. | |
| RO5045337 | RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Synonyms: R7112, RG7112, RG 7112; RG-7112; RO5045337; RO 5045337; RO-5045337. CAS No. 939981-39-2. Molecular formula: C38H48Cl2N4O4S. Mole weight: 727.786. | |
| Ro 51 | Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3 (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively), without significant activity on other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Synonyms: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol; Ro51; Ro-51; CHEMBL494161; 1050670-85-3; SCHEMBL4970553. Grades: ≥98% by HPLC. CAS No. 1050670-85-3. Molecular formula: C17H23IN4O4. Mole weight: 474.29. | |
| RO5126766 | RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis. Synonyms: RO5126766; RO 5126766; RO-5126766; CH5126766; CH-5126766; CH 5126766. Grades: >98%. CAS No. 946128-88-7. Molecular formula: C21H18FN5O5S. Mole weight: 471.463. | |
| RO5166017 | RO5166017 is a highly potent, selective, and orally active agonist for the trace amine-associated receptor 1(TAAR1) with no significant activity at other targets. It is weak and rapidly metabolized (endogenous ligands). It has strong pharmacological activity at other targets. Uses: Ro5166017 has strong pharmacological activity. Synonyms: RO5166017; RO 5166017; RO-5166017; (4S)-4-[(N-ethylanilino)methyl]-4,5-dihydro-1,3-oxazol-2-amine;RO-5166017;(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine. Grades: >98 %. CAS No. 1048346-74-2. Molecular formula: C12H17N3O. Mole weight: 219.29. | |
| Ro5203280 | Ro5203280 is a small-molecular PLK1 inhibitor. Ro5203280 shows a high efficacy for suppressing nasopharyngeal carcinoma growth with low toxicity in mouse studies. It suppresses nasopharyngeal carcinoma growth by inducing G2-M arrest and mitotic arrest and finally induces apoptosis through inhibiting PLK1 phosphorylation. Ro5203280 may be a potential chemotherapeutic agent for nasopharyngeal carcinoma treatment. Synonyms: RO3280; RO-3280; RO 3280; Ro5203280; Ro-5203280; Ro 5203280. Grades: 0.98. CAS No. 1062243-51-9. Molecular formula: C27H35F2N7O3. Mole weight: 543.62. | |
| RO-5203648 | RO-5203648 is a novel selective full agonist of the trace amine-associated receptor 1 (TAAR1). It showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. It increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. It displayed clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties. Uses: Ro-5203648 displayed clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties. Synonyms: RO-5203648; RO 5203648; RO5203648; (4S)-4-(3,4-dichlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine;RO5203648;(S)-4-(3,4-dichlorophenyl)-4,5-dihydrooxazol-2-amine. Grades: >99 %. CAS No. 1043491-54-8. Molecular formula: C9H8Cl2N2O. Mole weight: 231.07. | |
| RO-5256390 | RO-5256390 is a novel selective full agonist of the trace amine-associated receptor 1 (TAAR1). It blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties. It promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models. It may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain. It may be used as treatment of cocaine addiction. Uses: Ro-5256390 has antipsychotic-like properties. it may be used as treatment of cocaine addiction. Synonyms: RO5256390; RO 5256390; RO-5256390; (S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine;(4S)-4-[(2S)-2-phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine. Grades: >98 %. CAS No. 1043495-96-0. Molecular formula: C13H18N2O. Mole weight: 218.30. | |
| Ro 5-3335 | Ro 5-3335, a benzodiazepine, is a core binding factor (CBF) leukemia inhibitor. It is highly active in vitro (IC50 = 0.1-1.0 microM [corrected]) against HIV-1 viruses of AIDS resistant or non-resistant to zidovudine (AZT). Synonyms: Ro 5-3335; Ro-5-3335; Ro 5 3335; 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-pyrrol-2-yl- (7CI,8CI); NSC 66020; NSC66020; NSC-66020. Grades: ≥98% by HPLC. CAS No. 30195-30-3. Molecular formula: C13H10ClN3O. Mole weight: 259.69. | |
| Ro 60-0175 fumarate | Ro 60-0175 fumarate is a potent and selective SR-2 agonist. It is a potent, selective 5-HT2 receptor agonist, with selectivity for the 5-HT2C subtype (pKi= 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Synonyms: Ro 60-0175 fumarate; Ro-60-0175 fumarate; Ro 60 0175 fumarate; Ro600175 fumarate; (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate. Grades: ≥98% by HPLC. CAS No. 169675-09-6. Molecular formula: C11H12ClFN2.C4H4O4. Mole weight: 342.75. | |
| Ro 64-5229 | Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. Synonyms: Ro64-5229; Ro64-5229; Ro64-5229; (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole; (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole; (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole (9CI); 1-[(1Z)-2-(Cycloheptyloxy)-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole. Grades: ≥99% by HPLC. CAS No. 246852-46-0. Molecular formula: C17H19Cl2N3O. Mole weight: 352.26. | |
| Ro 67-4853 | Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1) (pEC50 value is 7.16 for the rat mGlu1a receptor). It also enhance glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors. Synonyms: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester; Ro67-4853; Ro 67-4853; Ro-67-4853. Grades: ≥99% by HPLC. CAS No. 302841-89-0. Molecular formula: C19H19NO4. Mole weight: 325.36. | |
| Ro 8-4304 hydrochloride | Ro 8-4304 hydrochloride is a non-competitive NMDA receptor antagonist with > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Synonyms: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride; Ro 8-4304; Ro84304; Ro-8-4304; Ro 8-4304 hydrochloride; Ro 8-4304 HCl. Grades: ≥99% by HPLC. CAS No. 1312991-77-7. Molecular formula: C21H23FN2O3.HCl. Mole weight: 406.88. | |
| RO8994 | RO8994, a spiroindolinone derivative, is an effective MDM2 inhibitor and has been found to have prabable activity against haematological malignancies. IC50: 5 nM and 20 nM in HTRF binding assays and MTT proliferation assays respectively. Uses: Ro8994 is an effective mdm2 inhibitor and has been found to have prabable activity against haematological malignancies. Synonyms: RO8994; RO-8994; RO 8994. Grades: 98%. CAS No. 1309684-94-3. Molecular formula: C31H31Cl2FN4O4. Mole weight: 613.51. | |
| RO9021 | RO9021 is ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK) with IC50 value of 5.6 nM. RO-9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90). This indicates that SYK is the only kinase with 99% competition with RO-9021 (1 uM) in a total of 392 tested kinases. RO9021 also can selectively suppress B-cell receptor signaling. Synonyms: RO-9021; RO 9021; RO9021. 6-[(1R,2S)-2-Amino-cyclohexylamino]-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide. Grades: 98%. CAS No. 1446790-62-0. Molecular formula: C18H25N7O. Mole weight: 355.45. | |
| Ro 90-7501 | Ro 90-7501, under the IUPCA name 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine, a type of aminoquinolines, is an inhibitor of Aβ42 fibril assembly so that can reduce Aβ42-induced toxicity (EC50 = 2 μM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: RO 90-7501; RO 90 7501; RO 907501; RO907501; RO-90-7501; 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine; Ro 90-7501; 293762-45-5; GNF-Pf-5510; STK367782; CBChromo1_000149; AC1LGN68; Cambridge id 5180073; CBDivE_006377; R0529_SIGMA; CHEMBL578741; SCHEMBL10002475; STOCK2S-20922; CTK8E9490; DTXSID80356431; HMS3262E21; HMS3269A19; Tox21_500670; ZINC18206988; AKOS000635167; AKOS001483260; CCG-221974; LP00670; MCULE-7528949788; NCGC00094031-06; NCGC00261355-01; BAS 03420670; HE063215; HE332505; ST078196; AB00074940-01; AG-690/09405007; BRD-K58299615-001-02-7; 3B1-004024; 2'-(4-aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine; 2'-(4-aminophenyl)-1H,1'H-2,5'-bibenzimidazol-5-amine; 2-[2-(4-aminophenyl)benzimidazol-6-yl]benzimidazole-6-ylamine; 2'-(4-Amino-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-ylamine; 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine; Ro 90-7501|2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine; 2-[2-(4-aminophenyl)-1H-1,3-benzodiazol-6-yl]-1H-1,3-benzodiazol-6-amine; 2-[2-(4-AMINOPHENYL)-3H-1,3-BENZODIAZOL-5-YL]-3H-1,3-BENZODIAZOL-5-AMINE. CAS No. 293762-45-5. Molecular formula: C20H16N6. Mole weight: 340.39. | |
| RO-9187 | RO-9187 is a potent inhibitor of HCV virus replication in the replicon system. It is excellent substrates for deoxycytidine kinase and were phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. It is a new class of antiviral nucleoside with promising preclinical properties as potential medicines for the treatment of HCV infection. Synonyms: RO-9187; RO 9187; RO9187. Grades: >98%. CAS No. 876708-03-1. Molecular formula: C9H12N6O5. Mole weight: 284.23. | |
| Robotnikinin | Robotnikinin is an inhibitor of Shh signaling that functions via repressing Gli-mediated transcription in primary human keratinocytes and synthetic human skin in a concentration-dependent manner. Synonyms: N-[(4-Chlorophenyl)methyl]-2-(5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetamide. Grades: ≥97%. CAS No. 1132653-79-2. Molecular formula: C25H27ClN2O4. Mole weight: 455. | |
| ROCK-IN-1 | A potent inhibitor of ROCK2 (IC50= 1.2 nM). Synonyms: [1,1'-Biphenyl]-3-carboxamide, 6-(1-aminoethyl)-4'-fluoro-N-4-pyridinyl-. CAS No. 934387-35-6. Molecular formula: C20H18FN3O. Mole weight: 335.37. | |
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