BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| p-MPPI | p-MPPI is a selective 5-HT1A antagonist. Synonyms: 4-Mppi; 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine; 4-Iodo-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinylbenzamide. Grades: 98%. CAS No. 155204-23-2. Molecular formula: C25H27IN4O2. Mole weight: 542.41. |  |
| PMX 53c | PMX 53c is negative control for PMX 53. PMX-53 functions as a potent CD88 antagonist and a low-affinity agonist for MrgX2. Furthermore, Trp and Arg residues are required for the ability of PMX53 to act as both a CD88 antagonist and a MrgX2 agonist. Synonyms: PMX 53c; PMX-53c; PMX53c; N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide. CAS No. 827600-15-7. Molecular formula: C39H60N10O7. Mole weight: 780.96. | |
| p-nitro-Cyclic Pifithrin-α | p-nitro-Cyclic PFT-α is a cell-permeable p53 inhibitor that prevents p53 posttranscriptional activity. Synonyms: Cyclic pifithrin-α-p-nitro; p-nitro-Cyclic PFT-&alpha. Grades: ≥95%. CAS No. 60477-38-5. Molecular formula: C15H13N3O2S. Mole weight: 299.3. | |
| p-nitro-Pifithrin-α | p-nitro-Pifithrin-α is a cell-permeable p53 inhibitor. It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-&alpha. It also suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet. Synonyms: p-nitro-PFT-α; 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone hydrobromide. Grades: ≥95%. CAS No. 389850-21-9. Molecular formula: C15H15N3O3S·HBr. Mole weight: 398.3. | |
| PNRI-299 | PNRI-299 is a selective AP-1 transcription inhibitor without affecting NF-kappaB transcription or thioredoxin. Synonyms: PNRI-299; PNRI299; PNRI 299. Grades: >98%. CAS No. 550368-41-7. Molecular formula: C21H15N5O4. Mole weight: 401.37. | |
| PNU-104489 | PNU-104489, a sulfonamidoindol derivative, has been found to be a HIV-1 specific inhibitor and was proved to exhibit activity against BHA-P-resistant HIV-1MF harboring the Pro-236->Leu RT. Synonyms: U 104489; U-104489; U104489; PNU-104489; PNU104489; PNU 104489; Alkylamino-piperidine analog; 1-((5-Methanesulfonamidoindol-2-yl)carbonyl)-4-(N-ethyl-N-(3-((1,1-dimethylethyl)amino)-2-pyridinyl)amino)piperidine. Grades: 98%. CAS No. 177577-60-5. Molecular formula: C26H36N6O3S. Mole weight: 512.67. | |
| PNU-120596 | PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. Synonyms: PNU-120596; PNU 120596; PNU120596; NSC 216666; NSC-216666; NSC216666. Grades: >98%. CAS No. 501925-31-1. Molecular formula: C13H14ClN3O4. Mole weight: 311.72. | |
| PNU 142633 | PNU 142633 is a selective, high affinity 5-HT1D receptor antagonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively). It is an experimental drug candidate for the treatment of migraine. Synonyms: (1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide; PNU-142633; PNU 142633; PNU142633. Grades: ≥98% by HPLC. CAS No. 187665-65-2. Molecular formula: C24H30N4O3. Mole weight: 422.53. | |
| PNU177836 | PNU177836 is an esteemed inhibitor, finding extensive utilization in the research of maladies, encompassing cancer, neurodegenerative disorders as well as ischemic heart diseases. Synonyms: PNU177836; 5-(2-{2-[(TERT-BUTOXY-HYDROXY-METHYL)-AMINO]-1-HYDROXY-3-PHENYL-PROPYLAMINO}-3-HYDROXY-3-PENTYLAMINO-PROPYL)-2-CARBOXYMETHOXY-BENZOIC ACID; DB02977; Q27465943; 5-[(2S,3R)-2-{[(1S,2S)-2-{[(S)-tert-butoxy(hydroxy)methyl]amino}-1-hydroxy-3-phenylpropyl]amino}-3-hydroxy-3-(pentylamino)propyl]-2-(carboxymethoxy)benzoic acid. Molecular formula: C31H47N3O9. Mole weight: 605.72. | |
| PNU 177864 | PNU 177864, a trifluromethoxy-phenylsulphonylamine, is a highly selective dopamine D3 receptor antagonist, which induces phospholipidosis and exhibits antischizophrenic activity in vivo. Synonyms: PNU 177864 hydrochloride; PNU177864 hydrochloride; PNU-177864 hydrochloride; N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 250266-51-4. Molecular formula: C18H21F3N2O3S. Mole weight: 402.4. | |
| PNU 177864 hydrochloride | PNU 177864 is a selective dopamine D3 receptor antagonist with antischizophrenic activity. Synonyms: N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1783978-03-9. Molecular formula: C18H21F3N2O3S·HCl. Mole weight: 438.89. | |
| PNU 22394 hydrochloride | PNU 22394 is virtually a full agonist at 5-HT2C receptors (87% of 5-HT), but a partial agonist at 5-HT2A (65% of 5-HT), and 5-HT2B (<15% of 5-HT) receptors. It is non-selective between 5-HT2 receptor subtypes (Ki= 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Synonyms: PNU22394 hydrochloride; PNU-22394 hydrochloride; 1,2,3,4,5,6-Hexahydro-6-methyl-azepino[4,5-b]indole hydrochloride; Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro-6-methyl-, monohydrochloride; PNU 186053A; Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro-6-methyl-, hydrochloride (1:1). Grades: ≥99% by HPLC. CAS No. 15923-42-9. Molecular formula: C13H16N2.HCl. Mole weight: 236.74. | |
| PNU 282987 | PNU 282987 is a potent and selective agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits nootropic effects, suggesting its potential use in the treatment of schizophrenia. Synonyms: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide. Grades: ≥98%. CAS No. 711085-63-1. Molecular formula: C14H17ClN2O. Mole weight: 264.8. | |
| PNU 37883 hydrochloride | PNU 37883 is a potent, euglycemic vascular K-ATP blocker that also exerts a K+-sparing diuresis at higher doses. It selectively inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. PNU 37883 is useful biological tool in distinguishing between Kir6.1 and Kir6.2 chimeric protein functions as well as the different sulfonylurea-sensitive K+ channel subtypes. Uses: Diuretics. Synonyms: U 37883A; U37883A; U-37883A; PNU 37883; PNU37883; PNU-37883; N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 57568-80-6. Molecular formula: C21H35N3O.HCl. Mole weight: 381.98. | |
| PNU 96415E | PNU 96415E, chemically unrelated to clozapine, exhibits high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki= 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). PNU-96415E has a profile of behavioral effects in rodents very similar to that of clozapine, including complete discriminative stimulus generalization. Synonyms: PNU 96415E; PNU96415E; PNU-96415E; 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 170856-41-4. Molecular formula: C21H25FN2O.2HCl. Mole weight: 413.36. | |
| Poloxin | Poloxin is the first small-molecule inhibitor specifically targeting the function of the Plk1 PBD. Poloxin induces centrosome fragmentation and abnormal spindle and chromosome misalignment, which activate the spindle assembly checkpoint and prolong mitosis. Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes. Moreover, Poloxin strongly inhibits proliferation of a panel of cancer cells by inducing mitotic arrest, followed by a surge of apoptosis. More important, we report, for the first time to our knowledge, that the PBD inhibitor, Poloxin, significantly suppresses tumor growth of cancer cell lines in xenograft mouse models by lowering the proliferation rate and triggering apoptosis in treated tumor tissues. Targeting the PBD by Poloxin is a powerful approach for selectively inhibiting Plk1 function in vitro and in vivo. Synonyms: Poloxin. Grades: 0.98. CAS No. 321688-88-4. Molecular formula: C18H19NO3. Mole weight: 297.354. | |
| Polyadenylic acid-Polyuridylic acid sodium salt | Cas No. 24936-38-7. | |
| Ponalrestat | Ponalrestatis an aldose reductase inhibitor originator byAstraZeneca. It can block the conversion of glucose to sorbitol. Ponalrestatis shows selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM. Phase III for the treatment of diabetes was discontinued. Uses: Diabetes. Synonyms: Ponalrestat, ICI-128436; ICI 128436; ICI128436; MK-538; MK 538; MK538. Brand name: Statil; Statyl. QJ0339; QJ0339; QJ-0339; 2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid. Grades: 98%. CAS No. 72702-95-5. Molecular formula: C17H12BrFN2O3. Mole weight: 391.20. | |
| Posaconazole hydrate | Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses. Synonyms: SCH56592 hydrate; SCH-56592 hydrate; SCH 56592 hydrate. Grades: >98%. CAS No. 1198769-38-8. Molecular formula: C37H44F2N8O5. Mole weight: 718.79. | |
| Posizolid | Posizolid is an oxazolidinone antibiotic that had been in phase II clinical trials for the treatment of tuberculosis but was discontinued. Synonyms: (4R)-3-[4-[1-[(2S)-2,3-dihydroxypropanoyl]-3,6-dihydro-2H-pyridin-4-yl]-3,5-difluorophenyl]-4-(1,2-oxazol-3-yloxymethyl)-1,3-oxazolidin-2-one; AZD-5847; AZD5847; AZD 5847; AZD2563; AZD 2563; AZD-2563, Posizolid. Grades: >98%. CAS No. 252260-02-9. Molecular formula: C21H21F2N3O7. Mole weight: 465.40. | |
| Poziotinib | Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: HM781-36B; NOV120101; NOV-120101; NOV 120101; Poziotinib. CAS No. 1092364-38-9. Molecular formula: C23H21Cl2FN4O3. Mole weight: 491.344. | |
| PP121 | PP121 is a multitargeted dual receptor tyrosine kinases inhibitor. PP121 blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases. Synonyms: PP121; PP 121; PP-121. CAS No. 1092788-83-4. Molecular formula: C17H17N7. Mole weight: 319.372. | |
| PP 3 | PP 3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2. It inhibits EGFR kinase (IC50 = 2.7 μM). Synonyms: PP 3; PP3; PP-3; 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 5334-30-5. Molecular formula: C11H9N5. Mole weight: 211.22. | |
| PPA-904 | PPA-904 is a specific phenothiazine photosensitizer that reached a phase II trial in patients with chronic venous Leg ulcer but was subsequently discontinued. Synonyms: PPA-904; PPA 904; PPA904; dibutyl-[7-(dibutylamino)phenothiazin-3-ylidene]azanium;bromide; Phenothiazin-5-ium, 3,7-bis(dibutylamino)-, bromide. CAS No. 30189-85-6. Molecular formula: C28H42BrN3S. Mole weight: 532.62. | |
| PPADS tetrasodium salt | PPADS tetrasodium salt, a non-selective P2 purinergic antagonist, blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. It delays onset of calcium responses to mild hypoosmotic stress in cortical slices. Synonyms: 1,3-Benzenedisulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-, sodium salt (1:4); 1,3-Benzenedisulfonic acid, 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-, tetrasodium salt; PPADS tetrasodium; 4-[2-[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic Acid; Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt. Grades: ≥95%. CAS No. 192575-19-2. Molecular formula: C14H10N3Na4O12PS2. Mole weight: 599.30. | |
| PPAHV | PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM), and is agonist at rat VR1(TRPV1) (EC50 between 3 and 10 μM) but virtually inactive at human VR1(TRPV1) (EC50>10 μM). It displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Synonyms: [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9-[phenylacetyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester benzeneacetic acid; Phorbol 12-phenylacetate 13-acetate 20-homovanillate. Grades: ≥98% by HPLC. CAS No. 175796-50-6. Molecular formula: C39H44O11. Mole weight: 688.77. | |
| PPAR agonist 1 | An agonist of PPAR α and PPAR &gamma. Synonyms: Benzenepropanoic acid, α -methoxy-4-[[3-[4-[ (methylsulfonyl) oxy]phenyl]propyl]amino]-, (αS)-. CAS No. 539813-69-9. Molecular formula: C20H25NO6S. Mole weight: 407.48. | |
| PPARα-MO-1 | A potent PPARα modulator. Synonyms: Benzenepropanoic acid, α-ethoxy-4-[2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy]-. CAS No. 810677-36-2. Molecular formula: C27H37NO5. Mole weight: 455.59. | |
| (±)-PPCC oxalate | (±)-PPCC oxalate is a selective sigma (σ) receptor ligand, which is noted to exhibit high affinity for σ1 and also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Synonyms: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester; (1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic Acid Methyl Ester Ethanedioate (2:1). Grades: ≥99% by HPLC. CAS No. 932736-91-9. Molecular formula: C24H29NO3.C2H2O4. Mole weight: 469.53. | |
| PPDA | PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (Ki= 0.096, 0.125, 0.31 and 0.55 μM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively). PPDA with its high affinity and distinct subunit selectivity may represent an important lead compound for the development of NMDA receptor antagonists of yet greater selectivity. Synonyms: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 684283-16-7. Molecular formula: C21H18N2O5. Mole weight: 378.38. | |
| PPHT hydrochloride | PPHT hydrochloride is a potent and selective dopamine D2 agonist. Uses: Dopamine agonists. Synonyms: (+/-)-PPHT hydrochloride; 6-[2-phenylethyl(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride. Grades: 98%. CAS No. 71787-90-1. Molecular formula: C21H27NO.HCl. Mole weight: 345.91. | |
| PPM-18 | PPM-18 is a synthetic naphthoquinone compound and an anti-inflammatory agent. It potently inhibits the expression of inducible nitric oxide synthase (iNOS) via suppressing NF-κB activation in vitro and in vivo (IC50 = 5 μM). Synonyms: NSC 73233; n-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide; NQN-1; 2-Benzoylamino-1,4-naphthoquinone. Grades: ≥95%. CAS No. 65240-86-0. Molecular formula: C17H11NO3. Mole weight: 277.3. | |
| PPPA | PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki=0.13, 0.47, 1.10 and 3.86 μM for GluN2A, GluN2B, GluN2C and GluN2D subunits respectively). Some findings support the hypothesis that PPPA and reward synergize to enhance initiate dopamine (DA) excitation. Synonyms: (2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylic acid. CAS No. 113190-92-4. Molecular formula: C9H18NO5P. Mole weight: 251.22. | |
| PPQ-102 | PPQ-102 is a remarkable and highly specialized inhibitor, used in studying prostate cancer. Synonyms: PPQ-102; PPQ102; PPQ 102. CAS No. 931706-15-9. Molecular formula: C26H22N4O3. Mole weight: 438.487. | |
| PPT | PPT, also known as Propyl pyrazole triol, is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ER&alpha. PPT significantly decreased infarct size in an in vivo rabbit model of ischemia-reperfusion injury. PPT also exerts anti-diabetic effects in mouse models. Synonyms: 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol; Propyl pyrazole triol. Grades: ≥99% by HPLC. CAS No. 263717-53-9. Molecular formula: C24H22N2O3. Mole weight: 386.45. | |
| PPTN hydrochloride | PPTN, a 4,7-disubstituted 2-naphthoic acid derivative, is a high affinity and selective P2Y14 antagonist (KB = 434 pM) with >10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN blocks UDP-glucose-promoted chemotaxis of human neutrophils and does so across a concentration range consistent with its KB determined in the P2Y14-R-expressing cell line. Synonyms: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 1992047-65-0. Molecular formula: C29H24F3NO2.HCl. Mole weight: 511.96. | |
| PPY A | PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50= 9 and 20 nM, respectively) that inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. Synonyms: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 875634-01-8. Molecular formula: C22H20N4O2. Mole weight: 372.42. | |
| PQ-10 | PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10). Synonyms: 6,7-dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline. Grades: ≥98%. CAS No. 927691-21-2. Molecular formula: C22H21N5O3. Mole weight: 403.4. | |
| PQ 401 | PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. Synonyms: PQ401; PQ-401; PQ 401. Grades:>98%. CAS No. 196868-63-0. Molecular formula: C18H16ClN3O2. Mole weight: 341.79. | |
| PQ 69 | PQ 69 is a potent and selective A1 receptor inverse agonist, with high binding affinity at A1 receptor (Ki= 0.07 and 0.96 nM for rat and human receptors respectively). It exhibits 217-fold more selective compared with hA2A receptors and >1,000-fold selectivity for hA1 over hA3 receptor. PQ-69 exhibits potent antagonist effects on A1AR in vitro, ex vivo and in vivo. Synonyms: 4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one; PQ-69; PQ 69; PQ69. Grades: ≥98% by HPLC. CAS No. 910045-32-8. Molecular formula: C20H19FN4O. Mole weight: 350.39. | |
| PQCA | This active molecular is a muscarinic M1 receptor positive allosteric modulator which is able to improve cognitive measures in rat and rhesus monkeys. PQCA is very efficient in rodent and nonhuman primate (NHP) cognition assays and it can improve performance on translatable tests of Memory and Attention in rhesus monkeys. PQCA attenuates learning and memory deficits in Alzheimer's disease model. PQCA may be potential useful in treating Alzheimer's diseases in the future. Uses: Treatment of alzheimer's diseases. Synonyms: 1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid,1401512-98-8 (sodium). Grades: 98%. CAS No. 1144504-35-7. Molecular formula: C22H20N4O3. Mole weight: 388.43. | |
| PQR309 | PQR309, a pan inhibitor of phosphoinositide-3-kinases, is still under Phase II clinical trial against Glioblastoma and Lymphoma. Uses: Pqr309 is a pan inhibitor of phosphoinositide-3-kinases and is still under phase ii clinical trial against glioblastoma and lymphoma. Synonyms: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine; PQR309; PQR-309; PQR309; Bimiralisib free base. Grades: 98%. CAS No. 1225037-39-7. Molecular formula: C17H20F3N7O2. Mole weight: 411.38. | |
| PQR530 | PQR530 is a potent dual pan PI3K/mTOR inhibitor undergoing phase II clinical trials in 2016. Aberrant activation of the PI3K/mTOR signaling pathway promotes the growth of malignant tumor cells. Study showed that PQR530 inhibited all PI3K isoforms and the mammalian target of rapamycin (mTOR) complexes C1/2 potently and selectively against tumor progression. Synonyms: PQR530; PQR0530; PQR 530. (S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine. Grades: ≥98%. CAS No. 1927857-61-1. Molecular formula: C18H23F2N7O2. Mole weight: 407.42. | |
| PR-073 | PR-073 is a novel 5-HT7 antagonist, which can inhibit immune responses and treat inflammatory bowel disease (IBD). Preclinical studies demonstrated that PR-073 has a high potency (Ki = 89 nM) and selectivity. Its oral bioavailability in the mouse is 17% as well as half-life is 3.4 h after oral dosing. Uses: The treatment of inflammatory bowel disease (ibd). Synonyms: PR-073; PR 073; PR073. | |
| PR-619 | Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells. Synonyms: PR-619; PR 619; PR619. CAS No. 2645-32-1. Molecular formula: C7H5N5S2. Mole weight: 223.272. | |
| Practolol | Practolol is a selective beta-1 adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. lt competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. lt inhibits the effects of the catecholamines epinephrine and norepinephrine and decreases heart rate, cardiac output, and systolic and diastolic blood pressure. lt has anti-hyperstensive activity. Uses: Practolo has been used in the emergency treatment of cardiac arrhythmias. lt has anti-hyperstensive activity. Synonyms: Practolol; Dalzic; Eraldin; Teranol; ICI 50172; Eralzdin Practolol; ICI 50172; ICI-50172; ICI50172; Practolol; Practolol, Eralzdin; Practololum;N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide;rac Practolol; (±)-Practolol; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; Dalzic; Eraldin; 4'-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilide; ICI-50172; ICI50172. Grades: 98%. CAS No. 6673-35-4. Molecular formula: C14H22N2O3. Mole weight: 266.34. | |
| Pramipexole | Pramipexole (Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. Uses: Antioxidants; antiparkinson agents; dopamine agonists. Synonyms: SND 919; SND919; SND-919. Grades: >98%. CAS No. 104632-26-0. Molecular formula: C10H17N3S. Mole weight: 211.33. | |
| Prasugrel Hydrochloride | Prasugrel is a platelet inhibitor (IC50=1.8 μM) , as a third-generation thienopyridine. Uses: Antiplatelets; antithrombotics. Synonyms: [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate;hydrochloride. Grades: ≥98%. CAS No. 389574-19-0. Molecular formula: C20H21ClFNO3S. Mole weight: 409.9. | |
| Prasugrel Maleic acid | Prasugrel is a platelet inhibitor (IC50=1.8 μM) , as a third-generation thienopyridine. Uses: Antiplatelets; antithrombotics. Synonyms: Save3DZoom 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate (2Z)-2-butenedioate (1:1). Grades: ≥98%. CAS No. 389574-20-3. Molecular formula: C24H24FNO7S. Mole weight: 489.51. | |
| Pravadoline | Pravadoline is a COX inhibitor and cannabinoid CB agonist used as an anti-inflammatory and analgesic agent. It inhibits prostaglandin synthesis, and it also suppresses neuronally stimulated contractions in mouse model, which differs from NSAIDs. Synonyms: Methanone, (4-methoxyphenyl)[2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-; (4-Methoxyphenyl)[2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]methanone; (4-Methoxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone; WIN 48098. Grades: 99%. CAS No. 92623-83-1. Molecular formula: C23H26N2O3. Mole weight: 378.46. | |
| Pravastatin | Pravastatin is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase with IC50 of 5.6 μM. It is used in combination with diet, exercise, and weight loss for lowering cholesterol and preventing cardiovascular disease. It is a synthetic lipid-lowering agent. It lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. It is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Uses: Pravastatin acts as a competitive inhibitor of hmg coa reductase. it is a synthetic lipid-lowering agent. it is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. it is used to reduce ldl cholesterol and triglyceride levels and increase hdl cholesterol in the prevention of cardiovascular disease. Synonyms: 1-Naphthaleneheptanoicacid, 1, 2, 6, 7, 8, 8a-hexahydro-b, d, 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, [1S-[1a(bS*, dS*), 2a, 6a, 8b(R*), 8aa]]-; 3b-Hydroxycompactin; Eptastatin; Mevalothin; Pravastatin acid;Pravachol; Pravastatina; Pravastatine; Pravastatinum; (3R, 5R)-7-[(1S, 2S, 6S, 8S, 8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1, 2, 6, 7, 8, 8a-hexahydronaphthalen-1-yl]-3, 5-dihydroxyheptanoic acid. Grades: 98%. CAS No. 81093-37-0. Molecular formula: C23H36O7. Mole weight: 424.53. | |
| Prazobind | Prazobind is an α1-adrenergic receptor (AR) antagonist, exhibiting antihypertensive properties. Synonyms: SZL-49; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone. Grades: ≥95%. CAS No. 107021-36-3. Molecular formula: C23H27N5O3. Mole weight: 421.5. | |
| Prazosin | Prazosin, a selective and orally active antagonist of adrenergic alpha-1, is a synthetic piperazine derivative to treat high blood pressure and anxiety, PTSD, and panic disorder. Uses: Adrenergic alpha-1 receptor antagonists. Synonyms: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone Douglas Brand of Prazosin Hydrochloride Furazosin HCL, Prazosin Hydrochloride, Prazosin Minipress Pfizer Brand of Prazosin Hydrochloride Pratsiol Prazosin Prazosin HCL Prazosin. Grades: 95%. CAS No. 19216-56-9. Molecular formula: C19H21N5O4. Mole weight: 383.40. | |
| PRE-084 hydrochloride | PRE-084 hydrochloride is a high affinity, selective receptors exhibiting neuroprotective effects. Its IC50 value is 44 nM in the sigma receptor assay. In vitro, it has an IC50 of more than 100,000 nM for PCP receptors. In vivo, it has nootropic and antidepressant actions and has antitussive and reinforcing effects. It could improve motor neuron survival and motor performance in wobbler mice. It enhances BDNF-mediated trophic support. Uses: Pre-084 hydrochloride has nootropic and antidepressant actions and has antitussive and reinforcing effects in vivo. it could improve motor neuron survival and motor performance in wobbler mice. it enhances bdnf-mediated trophic support. Synonyms: PRE-084 hydrochloride; PRE 084 hydrochloride; PRE084 hydrochloride; 1-Phenylcyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester hydrochloride;Cyclohexanecarboxyli?c acid, 1-phenyl-, 2-(4-morpholinyl)?ethyl ester, hydrochloride (1:1). Grades: 98%. CAS No. 75136-54-8. Molecular formula: C19H28NO3Cl. Mole weight: 353.88. | |
| Pregnanolone | Pregnanolone, also known as Kabi-2213, SKF 6455, Eltanolone, is a GABAA receptor positive allosteric modulator potentially for the treatment of pain. Uses: Anesthetics. Synonyms: Pregnanolone; Kabi-2213; Kabi 2213; Kabi2213; SKF 6455; SKF6455; Eltanolone; 3a5b-Pregnanolone. CAS No. 128-20-1. Molecular formula: C21H34O2. Mole weight: 318.49. | |
| Pregnenolone sulfate sodium salt | Pregnenolone sulfate, a metabolite of the natural steroid hormone pregnenolone, is a neurosteroid that has been demonstrated to antagonize the GABAA receptor chloride channel. Synonyms: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt; (3β-3-(Sulfooxy)pregn-5-en-20-one Sodium Salt; 3β-Hydroxypregn-5-en-20-one Hydrogen Sulfate Sodium Salt; Pregnenolone Sulfate Sodium Salt. CAS No. 1852-38-6. Molecular formula: C21H31NaO5S. Mole weight: 418.52. | |
| Prenyl-IN-1 | Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor. Synonyms: Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-2-phenoxy-. CAS No. 360561-53-1. Molecular formula: C28H24ClN5O2. Mole weight: 497.98. | |
| Prexasertib mesylate | Prexasertib, also known as LY2606368, is an ATP-competitive CHK1 inhibitor (Ki= 0.9 nmol/L), with minor activity against CHK2 and RSK with IC50= 8 nM and 9 nM respectively in cell-free assay. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population. Synonyms: 2-Pyrazinecarbonitrile, 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)-, methanesulfonate; Prexasertib mesylate; LY2606368; LY-2606368; LY 2606368. CAS No. 1234015-55-4. Molecular formula: C19H23N7O5S. Mole weight: 461.49. | |
| PRIMA-1 | PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high μM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. Synonyms: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one. Grades: ≥99% by HPLC. CAS No. 5608-24-2. Molecular formula: C9H15NO3. Mole weight: 185.22. | |
| Primaquine bisphosphate | Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria. Uses: Antimalarials. Synonyms: 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid. Grades: > 98 %. CAS No. 63-45-6. Molecular formula: C15H21N3O · 2H3PO4. Mole weight: 455.34. | |
| [Pro3]-GIP (Mouse) | [Pro3]-GIP (Mouse) is a GIP receptor antagonist (IC50 = 2.6μM). It suppresses GIP-stimulated insulin release from pancreatic β cells in vitro. It blocks the effects of GIP on insulin release and plasma glucose levels in ob/ob mice. Grades: ≥97%. Molecular formula: C225H342N62O64S. Mole weight: 4971.62. | |
| [Pro3]-GIP (Rat) | [Pro3]-GIP (Rat) is a high affinity partial agonist at rat GIP receptor (Kd = 13 nM). It increases cAMP accumulation in COS-7 cells transfected with rat GIP receptor, while also acting as a competitive antagonist of GIP. Grades: ≥95%. Molecular formula: C226H343N61O64S. Mole weight: 4970.63. | |
| Prochlorperazine Dimaleate | Prochlorperazine is a dopamine D2 receptor antagonist. It belongs to the phenothiazine class of antipsychotic agents and can be used for the antiemetic treatment of nausea and vertigo. Prochlorperazine is also used to treat migraine headaches. Uses: Nausea and vertigo. Synonyms: Buccastem; Compazine; Emetiral; Meterazin Maleate; Pasotomin;Prochlorperazine Hydrogen Maleate; Prochloroperazine Dimaleate; Prochlorperazine Maleate; Stemetil; Stemetil Dimaleate; Vertigon. Grades: 98%. CAS No. 84-02-6. Molecular formula: C20H24ClN3S.C8H8O8. Mole weight: 606.09. | |
| Procodazole | Procodazole, widely used as an immunomodulator against viral and bacterial infections, after administration it reduced the parasitic burden. Synonyms: 3-(1H-benzimidazol-2-yl)propanoic acid benzimidazolyl-2-propionic acid procodazol propazole propazole, monosodium salt. CAS No. 23249-97-0. Molecular formula: C10H10N2O2. Mole weight: 190.20. | |
| Procyclidine hydrochloride | The hydrochloride salt form of Procyclidine which has been found to be a muscarinic antagonist that could be effective against Parkinson's disease and some related disorders. Synonyms: Procyclidine hydrochloride; Procyclidine HCl; Tricyclamol hydrochloride; (-)-Tricyclamol iodide; Procyclidine (hydrochloride); 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride. Grades: 98%. CAS No. 1508-76-5. Molecular formula: C19H29NO.HCl. Mole weight: 323.90. | |
| Progabide | Progabide is a gamma-aminobutyric acid (GABA) antagonist. It has agonistic activity for both the GABAA and GABAB receptors. It has antiepileptic activity and is commonly used in the treatment of epilepsy. It also has been used for many diseases, including schizophrenia, Parkinson's disease, clinical depression and anxiety disorder with varying success. Uses: Progabide has antiepileptic activity and is commonly used in the treatment of epilepsy. it also has been used for many diseases, including schizophrenia, parkinson's disease, clinical depression and anxiety disorder with varying success. Synonyms: Progabide; Halogabide; Gabrene; Gabren; Progabida; Progabidum; progabide; SL 76002; SL76002; SL-76002; DB00837; DB 00837; DB-00837; LS-45438; LS 45438; LS45438; 4-[[ (4-Chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene]amino]butanamide; Gabren; Gabrene; Halogabide; SL76-002; SL76002; (E) -4- ( (4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methyleneamino) butanamide; 4-[[ (Z) - (4-Chlorophenyl) - (3-fluoro-6-oxo-1-cyclohexa-2, 4-dienyli. Grades: 95%. CAS No. 62666-20-0. Molecular formula: C17H16ClFN2O2. Mole weight: 334.77. | |
| Proglumide sodium salt | Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. Synonyms: 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt. Grades: ≥99% by HPLC. CAS No. 99247-33-3. Molecular formula: C18H25N2NaO4. Mole weight: 356.39. | |
| Proguanil hydrochloride | Proguanil hydrochloride is the hydrochloride salt form of proguanil, which is a synthetic biguanide derivative of pyrimidine. It is used as an folate antagonist with antimalarial property. It is used to treat and prevent malaria together with chloroquine or atovaquone. lt is converted by the liver to its active metabolite, cycloguanil. It may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. It was developed by AstraZeneca and has been listed. Uses: Proguanil hydrochloride is used as an folate antagonist with antimalarial property. Synonyms: 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride; 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride; 3359rp; chlorguanidehydrochloride; chloroguanidehydrochloride; chloroguanidinehydrochloride; diguanyl; drinupalhydrochloride. Grades: BP/EP/USP. CAS No. 637-32-1. Molecular formula: C11H17Cl2N5. Mole weight: 290.19. | |
| Promethazine hydrochloride | Promethazine hydrochloride is first-generation antihistamine of the phenothiazine family used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. It shows an effect against allergy via inhibiting histamine H1. Uses: Antihistaminic, antiemetic. Synonyms: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride; N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride. Grades: ≥98%. CAS No. 58-33-3. Molecular formula: C17H21ClN2S. Mole weight: 320.88. | |
| Pronetalol | Pronethalol is a non-selective beta-adrenergic blocking agentused in treatment due to carcinogenic properties. Uses: A non-selective beta blocker. Synonyms: 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol; Naphthylisoproterenol; Nethalide. Grades: ≥95%. CAS No. 54-80-8. Molecular formula: C15H19NO. Mole weight: 229.32. | |
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