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Pavinetant
Pavinetant is a selective neurokinin-3 (NK3) receptor antagonist under the development of hot flashes, polycystic ovary syndrome (PCOS) and schizophrenia treatment. Synonyms: AZD 2624; AZD 4901;MLE-4901; 3-(methanesulfonamido)-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide. Grades: ≥98%. CAS No. 941690-55-7. Molecular formula: C26H25N3O3S. Mole weight: 459.6.
Pazufloxacin
Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively. Synonyms: T-3761; T3761; T 3761. Grades: >98%. CAS No. 127045-41-4. Molecular formula: C16H15FN2O4. Mole weight: 318.3.
PB 28 dihydrochloride
PB 28 dihydrochloride is a high affinity σ2 receptor agonist. It displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells. Synonyms: PB 28 dihydrochloride; PB28 dihydrochloride; PB-28 dihydrochloride; 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 172907-03-8. Molecular formula: C24H38N2O.2HCl. Mole weight: 443.5.
PBOX-15
PBOX-15 is a novel microtubule inhibitor, which induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Uses: Microtubule inhibitor. Synonyms: PBOX-15; PBOX15; PBOX 15; 5-(naphthalen-1-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate. Grades: ≥98%. CAS No. 354759-10-7. Molecular formula: C28H19NO3. Mole weight: 417.13.
PC786
PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. It exhibits potent antiviral activity against RSV-A and RSV-B. Synonyms: N-(2-fluoro-6-methylphenyl)-6-[4-[[5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyridine-3-carbonyl]amino]benzoyl]-4,5-dihydrothieno[3,2-d][1]benzazepine-2-carboxamide. Grades: 99.70%. CAS No. 1902114-15-1. Molecular formula: C41H38FN5O4S. Mole weight: 715.83.
PCI-27483
PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities. FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2). Upon subcutaneous administration, factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells. In addition, this agent inhibits both the extrinsic and intrinsic coagulation cascades, preventing blood clot formation. TF, a blood protein overexpressed on the cell surface of a variety of tumor cell types, may correlate with poor prognosis; PAR-2 (also known as thrombin receptor-like 1) is a G protein-coupled receptor (GPCR) and a protease-activated receptor. PCI-27483 is in a clinical trial for the treatment of advanced pancreatic cancer in combination with Gemcitabine. Synonyms: PCI27483; PCI 27483; (2S) -2-[[2-[3- (6-carbamimidoyl-1H-benzimidazol-2-yl) -4-hydroxy-5- (2-hydroxy-5-sulfamoylphenyl) phenyl]acetyl]amino]butanedioic acid. Grades: ≥98%. CAS No. 871266-63-6. Molecular formula: C26H24N6O9S. Mole weight: 596.6.
PCI 29732
Potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells. Synonyms: PCI-29732; PCI 29732; PCI29732. Grades: >98%. CAS No. 330786-25-9. Molecular formula: C22H21N5O. Mole weight: 371.44.
PCI-32765 Racemate
PCI-32765 Racemate is a potent and highly selective inhibitor of Bruton tyrosine kinase (BTK), modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. It is a covalent and irreversible inhibitor of BTK through bonding to Cys-481 in the ATP binding domain. It inhibits phosphorylation of BTK in a B cells as well as the downstream substrates phosphoinositide phospholipase Cγ (PLC γ) and ERK in cell assays. It has in vivo efficacy in B cell lymphoma and efficacious in autoimmune disease. It also diminished FcγRIII-induced production of pro-inflammatory cytokines. Synonyms: Ibrutinib Racemate; PCI-32765 Racemate; PCI 32765 Racemate; PCI32765 Racemate. Grades: >98%. CAS No. 936563-87-0. Molecular formula: C25H24N6O2. Mole weight: 440.5.
PCI-34051
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. PCI-34051 could offer benefits including a greater therapeutic index for treating T-cell malignancies. Synonyms: PCI-34051; PCI 34051; PCI34051. Grades: 0.98. CAS No. 950762-95-5. Molecular formula: C17H16N2O3. Mole weight: 296.326.
PD0176078
PD0176078 is a novel N-type calcium channel blocker. Synonyms: (2S)-N-[4,4-bis(4-fluorophenyl)butyl]-4-methyl-2-(methylamino)pentanamide; PD176078; PD 0176078; PD-0176078. CAS No. 248922-46-5. Molecular formula: C23H30F2N2O. Mole weight: 388.49.
PD 0332991 hydrochloride
PD 0332991 hydrochloride is a cyclin-dependent kinase (CDK) inhibitor with high affinity for CDK4 and CDK6. It has the potential for breast cancer treatment. Uses: Potential treatment of breast cancer. Synonyms: PD 0332991 hydrochloride; PD0332991 hydrochloride; PD-0332991 hydrochloride; Palbociclib HCl; Palbociclib hydrochloride; 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one hydrochloride. Grades: 99%. CAS No. 571189-11-2. Molecular formula: C24H29N7O2.37/20HCl. Mole weight: 514.99.
PD 102807
PD 102807 is a selective mAChR M4 antagonist with IC50 values of 91, 6559, 3441, 95 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. Synonyms: PD 102807; PD102807; PD-102807; 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester. Grades: ≥98% by HPLC. CAS No. 23062-91-1. Molecular formula: C23H24N2O4. Mole weight: 392.45.
PD-113413
PD-113413 is a metabolite of quinapril, which is an angiotensin-converting enzyme(ACE) inhibitor. It is used in the treatment of hypertension and congestive heart failure. Uses: Pd-113413 is used in the treatment of hypertension and congestive heart failure. Synonyms: PD-113413; PD113413; PD 113413; 2H-Pyrazino(1,2-b)isoquinoline-2-acetic acid, 1,3,4,6,11,11a-hexahydro-3-methyl-1,4-dioxo-alpha-(2-phenylethyl)-, (3S-(2(R*),3alpha,11abeta))-;(2S)-2-[(3S,11aS)-3-methyl-1,4-dioxo-3,6,11,11a-tetrahydropyrazino[1,2-b]isoquinolin-2-yl]-4-phenylbutanoic acid;PD113413;(S)-2-((3S,11aS)-3-methyl-1,4-dioxo-3,4,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-2(6H)-yl)-4-phenylbutanoic acid. Grades: >98 %. CAS No. 103733-50-2. Molecular formula: C23H24N2O4. Mole weight: 392.45.
PD-117302
PD-117302, a new nonpeptide opioid compound, is a selective kappa-opioid agonist. It has been evaluated in vivo for antinociceptive activity and other effects characteristic of kappa-receptor activation. It also causes naloxone-reversible locomotor impairment and diuresis. It is used as an Anticonvulsants, an Anti-Arrhythmia agent, a Central Nervous System agent and a Cardiovascular agent. Uses: Pd-117302 is used as an anticonvulsants, an anti-arrhythmia agent, a central nervous system agent and a cardiovascular agent. Synonyms: PD117302; PD-117302; PD 117302; Trans-N-Methyl-N-(2-(1-pyrrolidinyl)cyclohexyl-)benzo-(b)-thiophene-4-acetamide;Benzo(b)thiophene-4-acetamide, N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, trans-(+-)-;2-(1-Benzothiophen-4-yl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide;PD117302. Grades: >98%. CAS No. 111728-01-9. Molecular formula: C21H28N2OS. Mole weight: 356.52.
PD 118057
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, with no major effect on INa, ICa/L, IK1 and IKs currents. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure. Synonyms: 2-[[4-[2- (3, 4-Dichlorophenyl) ethyl]phenyl]amino]benzoic acid; PD-118057; PD118057; PD 118057. Grades: ≥99% by HPLC. CAS No. 313674-97-4. Molecular formula: C21H17Cl2NO2. Mole weight: 386.27.
PD-118440
PD-118440 is a dopamine antagonist. It was identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests including [3H]-haloperidol and [3H]-N-propylnorapomorphine binding. It inhibits striatal DA synthesis, DA neuronal firing and spontaneous locomotor activity. Synonyms: 2-Amino-4-[(1-propyl-1,2,5,6-tetrahydropyridin)-3-yl]thiazole;2-Thiazolamine,4-(1,2,5,6-tetrahydro-1-propyl-3-pyridinyl)-;4-(1-propyl-3,6-dihydro-2H-pyridin-5-yl)-1,3-thiazol-2-amine; PD118440; PD 118440; PD118440. Grades: >98%. CAS No. 108351-90-2. Molecular formula: C11H17N3S. Mole weight: 223.33.
PD-118717
PD-118717 is a putative piperazinyl benzopyranone dopamine autoreceptor(DA) agonist. It has the profile of a DA autoreceptor agonist in neurochemical and neurophysiological tests. It has antipsychotic efficacy without neurological side effect liability in preclinical behavioral tests. Uses: Pd-118717 has antipsychotic efficacy. Synonyms: PD-118717; PD 118717; PD118717; 2H-1-Benzopyran-2-one,7-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propoxy]-;7-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propoxy]chromen-2-one sulfuric acid;PD118717;7-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propoxy)-2H-chromen-2-one sulfate. Grades: >98 %. CAS No. 104229-37-0. Molecular formula: C20H24N4O7S. Mole weight: 464.49.
PD-119819
PD-119819, a heterocyclic piperazine, is an extremely selective DA autoreceptor agonist. It binds [3H]haloperidol in tests in rats. It inhibits of spontaneous locomotor activity and inhibits of brain DA synthesis or neuronal firing in tests in rats. Synonyms: 4H-1-Benzopyran-4-one,7-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]-, hydrochloride (1:2);7-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]chromen-4-one;PD119819; PD-119819; PD 119819. Grades: >98 %. CAS No. 105277-43-8. Molecular formula: C21H23N3O3. Mole weight: 365.43.
PD-120697
PD-120697 is a novel dopamine antagonist with central dopamine agonist properties. It was identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests including [3H]-haloperidol and [3H]-N-propylnorapomorphine binding. It inhibits striatal DA synthesis, DA neuronal firing and spontaneous locomotor activity. Synonyms: PD-120697; PD120697; PD 120697; 4-(1,2,5,6-Tetrahydro-1-allyl-3-pyridinyl)-2-thiazolamine;2-Thiazolamine, 4-[1,2,5,6-tetrahydro-1-(2-propen-1-yl)-3-pyridinyl]-;4-(1-Prop-2-enyl-3,6-dihydro-2H-pyridin-5-yl)-1,3-thiazol-2-amine;PD120697;4-(1-Allyl-1,2,5,6-tetrahydropyridin-3-yl)thiazol-2-amine. Grades: >98%. CAS No. 108351-91-3. Molecular formula: C11H15N3S. Mole weight: 221.32.
PD 122860
This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular contractility, decrease coronary resistance and alter the shape of the electrocardiogram T-wave in the animal model. PD 122860 can relax potassium-contracted aortic rings selectively and inhibit [3H] nitrendipine binding to rat brain membranes. But it is discontinued for Heart failure and Ischaemic heart disorders preclinical treatment in USA in 2000. Uses: Heart failure; ischaemic heart disorders. Synonyms: PD122860; PD-122860; PD 122860; ethyl 5-cyano-6-methyl-2-((pyridin-4-ylsulfonyl)methyl)-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate. Grades: 98%. CAS No. 122576-86-7. Molecular formula: C23H20F3N3O4S. Mole weight: 491.48.
PD 123177
PD 123177 is a Nonpeptide angiotensin type 2 receptor inhibitor. In Dec 1995, Preclinical development of it for cardiovascular disorders was began in USA. Uses: Cardiovascular disorders. Synonyms: Exp 655; Exp655; Exp-655; PD123177; PD-123177; PD 123177,1-[(4-amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid. Grades: 98%. CAS No. 114785-12-5. Molecular formula: C29H28N4O3. Mole weight: 480.56.
PD-123319 TFA salt
The ditrifluoroacetate salt form of PD-123319, a nonpeptide AT2R antagonist, could have potential effect against hypertension. It has already been discontinued by Pfizer for the study of hypertension. IC50: 34 nM. Uses: The ditrifluoroacetate salt form of pd-123319 is a nonpeptide at2r antagonist that could have potential effect against hypertension. Synonyms: (S)-1-(4-(dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2); PD-123319; PD 123319; PD123319; PD-123319 TFA; PD 123319 ditrifluoroacetate. Grades: 98%. CAS No. 136676-91-0. Molecular formula: C35H34F6N4O7. Mole weight: 736.66 (anhydrous basis).
PD 127443
This active molecular is a Leukotriene B4 antagonist. PD- 127443 is also a 5-lipoxygenase and cyclooxygenase inhibitor and it has been reported to have antiinflammatory effects in vivo. Uses: Antiinflammatory. Synonyms: PD-127443; PD127443; PD 127443; (E)-2,6-di-tert-butyl-4-(2-(5-methyl-1H-pyrazol-3-yl)vinyl)phenol. Grades: 98%. CAS No. 121502-05-4. Molecular formula: C20H28N2O. Mole weight: 312.45.
PD 128907
PD 128907 is a selective D2 and D3 dopamine receptor agonist that can be used as an antipsychotic. Uses: Antipsychotic. Synonyms: PD 128907; PD128907; PD-128907; 4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol; 2H,5H-[1]Benzopyrano[4,3-b]-1,4-oxazin-9-ol,3,4,4a,10b-tetrahydro-4-propyl-, (4aS,10bS)-rel-; 3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol. Grades: 99%. CAS No. 123594-64-9. Molecular formula: C14H19NO3. Mole weight: 249.31.
(+)-PD 128907 hydrochloride
(+)-PD 128907 hydrochloride, the more active enantiomer of trans-(±)-PD 128907, is a potent D3 dopamine receptor agonist (Ki = 2.3 nM), with 18-200-fold selectivity over other dopamine receptor subtypes. Synonyms: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride; (+)-PD 128907 HCl; (+)-PD-128907 HCl; (+)-PD128907 HCl; (+)-PD128907 hydrochloride; (+)-PD-128907 hydrochloride; (+)-PD 128907 hydrochloride; PBPO; PBTO. Grades: ≥99% by HPLC. CAS No. 300576-59-4. Molecular formula: C14H19NO3.HCl. Mole weight: 285.77.
PD 134922
PD 134922 has been found to be a HIV-1 protease inhibitor that could probably be effective against HIV infections. Synonyms: PD-134922; PD134922; PD 134922; AC1L3V1C; DTXSID30164523; AM008268; (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]-2-propan-2-ylhexanamide. Grades: 98%. CAS No. 150351-30-7. Molecular formula: C37H61N5O7S. Mole weight: 719.98.
PD 135158
PD 135158 is a nonpeptide CCK2 receptor antagonist. It also exhibits agonist activity at the rat pancreatic CCKA receptor to stimulate pancreatic enzyme secretion. Uses: Anti-anxiety agents. Synonyms: 4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[[[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid. Grades: ≥98% by HPLC. CAS No. 130285-87-9. Molecular formula: C35H44N4O6. Mole weight: 616.76.
PD 135390
PD 135390 has been found to be a HIV-1 protease inhibitor that could probably be effective against HIV infections. Synonyms: PD-135390; PD135390; PD 135390; 5-((2S)-N-(1-(allylthio)-2-amino-2-oxoethyl)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide. Grades: 98%. CAS No. 150351-31-8. Molecular formula: C37H61N5O7S2. Mole weight: 752.04.
PD 140248
PD 140248, a fluoronaphthyridine compound, has been found to have potential antibacterial effect especially against gram-positive pathogens. It has not been reported about its development status since 2000. Synonyms: PD-140248; PD140248; PD 140248; 7-(3-(1-Aminoethyl)-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 7-(3-(1-aminoethyl-1-pyrrolidinyl))-1-(2,4-difluorophenyl)-6-fluoro-1,4-d. Grades: 98%. CAS No. 147208-55-7. Molecular formula: C21H19F3N4O3. Mole weight: 432.39.
PD-140376
PD-140376 has been found to be a cholecystokininB/gastrin receptor antagonist that could probably be useful in the study of sorts of gastrointestinal disorders. Synonyms: PD-140376; PD 140376; AC1L52KZ; 3-((4-Aminophenyl)methyl)-N-(alpha-methyl-N-((tricyclo(3.3.1.1)dec-2-yloxy)carbonyl)-D-tryptophyl)-beta-alanine; OR223333. Grades: 98%. CAS No. 149027-97-4. Molecular formula: C33H40N4O5. Mole weight: 572.71.
PD 144418 oxalate
PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other receptors and that sigma 1 site may modulate actions in the CNS. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration, and also attenuates cocaine-induced hyperactivity in mice. Synonyms: PD 144418 oxalate; PD144418 oxalate; PD-144418 oxalate; 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate. Grades: ≥98% by HPLC. CAS No. 154130-99-1. Molecular formula: C18H22N2O.C2H2O4. Mole weight: 372.42.
PD 146176
PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM), without effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). It is known that PD-146176 acts as a noncompetitive inhibitor towards 15-LO, displaying a Ki=197 nM. Furthermore, PD-146176 reduces monocyte macrophage enrichment of atherosclerotic lesions and development of fibrofoamy and fibrous plaque. Synonyms: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole; PD 146176; PD-146176; PD146176; NSC 168807; NSC-168807; NSC168807. Grades: ≥98% by HPLC. CAS No. 4079-26-9. Molecular formula: C15H11NS. Mole weight: 237.32.
PD 150606
PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)). It targets the calcium binding sites of calpain. PD 150606 demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. Synonyms: PD-150606; PD150606. Grades: ≥95% by HPLC. CAS No. 179528-45-1. Molecular formula: C9H7IO2S. Mole weight: 306.12.
PD 151746
PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. Synonyms: PD-151746; PD 151746; PD151746. Grades: >98%. CAS No. 179461-52-0. Molecular formula: C11H8FNO2S. Mole weight: 237.25.
PD-153035
PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). Uses: Antineoplastic agents. Synonyms: AG 1517; AG1517; AG-1517; NSC 669364; NSC669364; NSC-669364; PD 153035; PD153035; SU 5271; SU5271; SU-5271; WHI-P 79. Grades: >98%. CAS No. 153436-54-5. Molecular formula: C16H14BrN3O2. Mole weight: 360.211.
PD153035 HCl
PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. Synonyms: SU5271; SU 5271; AG 1517; AG-1517; SU-5271 (AG1517) HCl; ZM 252868 HCl; ZM-252868 HCl; ZM252868 HCl; PD153035 HCl; PD 153035 HCl; PD-153035 HCl; AG 1517 hydrochloride; AG1517 hydrochloride; AG-1517 hydrochloride. Grades: >98%. CAS No. 183322-45-4. Molecular formula: C16H14BrN3O2.HCl. Mole weight: 396.67.
PD158780
PD158780 is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity with IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4). Synonyms: PD-158780; PD 158780; PD158780. Grades: >98%. CAS No. 171179-06-9. Molecular formula: C14H12BrN5. Mole weight: 330.18.
PD 160170
PD 160170 is a potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM), which is selective over Y2 and Y5 receptors (Ki > 10 μM). Synonyms: PD 160170; PD160170; PD-160170; 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine. Grades: ≥98% by HPLC. CAS No. 181468-88-2. Molecular formula: C18H17N3O4S. Mole weight: 371.41.
PD-161570
PD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. In addintion, PD-161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro. Synonyms: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; PD-161570; PD 161570; PD161570. CAS No. 192705-80-9. Molecular formula: C26H35Cl2N7O. Mole weight: 532.51.
PD 166285 dihydrochloride
PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. Synonyms: PD 166285 dihydrochloride; PD166285 dihydrochloride; PD-166285 dihydrochloride6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 212391-63-4. Molecular formula: C26H27Cl2N5O2.2HCl. Mole weight: 585.35.
PD 166793
PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. Synonyms: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine; PD-166793; PD 166793; PD166793; PD-166793-0000. Grades: ≥99% by HPLC. CAS No. 199850-67-4. Molecular formula: C17H18BrNO4S. Mole weight: 412.3.
PD 168077 maleate
PD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. It is suitable for central and peripheral delivery, and used in studies of penile erection, learning and memory. Synonyms: PD 168077 maleate; PD168077 maleate; PD-168077 maleate; N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate. Grades: ≥99% by HPLC. CAS No. 630117-19-0. Molecular formula: C20H22N4O.C4H4O4. Mole weight: 450.49.
PD-168393
PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice. Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; PD168393; PD 168393; PD-168393. CAS No. 194423-15-9. Molecular formula: C17H13BrN4O. Mole weight: 369.222.
PD 168568 dihydrochloride
PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki= 8.8 and 1842 nM at D4 and D2 receptors respectively). Synonyms: PD 168568 dihydrochloride; PD168568 dihydrochloride; PD-168568 dihydrochloride; 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride. Grades: ≥98% by HPLC. CAS No. 210688-56-5. Molecular formula: C22H27N3O.2HCl. Mole weight: 422.39.
PD 169316
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. Synonyms: PD-169316; PD 169316; PD169316. Grades: 98.0%. CAS No. 152121-53-4. Molecular formula: C20H13FN4O2. Mole weight: 360.348.
PD 173212
PD 173212 is a potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM), with selectivity over K+, Na+ and L-type Ca2+ channels. Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. Synonyms: PD-173212; PD 173212; PD173212; N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide. Grades: ≥98% by HPLC. CAS No. 217171-01-2. Molecular formula: C38H53N3O3. Mole weight: 599.85.
PD 174265
PD 174265 is a cell-permeable, reversible inhibitor of EGFR tyrosine kinase activity with IC50 value of 0.45 nM. Synonyms: 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline; N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide. Grades: ≥98%. CAS No. 216163-53-0. Molecular formula: C17H15BrN4O. Mole weight: 371.2.
PD 176252
PD 176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD 176252 inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Synonyms: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide; PD-176252; PD 176252; PD176252. Grades: ≥98% by HPLC. CAS No. 204067-01-6. Molecular formula: C32H36N6O5. Mole weight: 584.67.
PD 198306
PD 198306, an amino-benzamide compound, is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC50=8 nM). It inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30-100 nM. It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 μM). Synonyms: PD-198306; PD 198306; PD198306; N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide. Grades: ≥98% by HPLC. CAS No. 212631-61-3. Molecular formula: C18H16F3IN2O2. Mole weight: 476.23.
PD318088
PD318088 is a MEK inhibitor. Synonyms: PD318088; PD 318088; PD-318088. CAS No. 391210-00-7. Molecular formula: C16H13BrF3IN2O4. Mole weight: 561.094.
PD 334581
PD 334581, an analog of PD 184352, is an inhibitor of MEK1 that is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. Synonyms: PD 334581; PD334581; PD-334581; N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine. Grades: ≥98% by HPLC. CAS No. 548756-68-9. Molecular formula: C20H19F3IN5O2. Mole weight: 545.3.
PD 81723
PD 81723, an aminothiophene derivative, has been shown to act as an allosteric enhancer of the adenosine A1 receptor in brain membranes and thyroid cells, which acts via agonist-dependent and independent mechanisms. Synonyms: (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone; PD 81723; PD81723; NCGC00025124-01; CPD000468734; SAM001247067; PD-81,723; Methanone. Grades: ≥99% by HPLC. CAS No. 132861-87-1. Molecular formula: C14H12F3NOS. Mole weight: 299.31.
PDE10-IN-1 is a potent PDE10-IN-1 inhibitor
Cas No. 1516896-09-5.
PDE1-IN-1
PDE1-IN-1 is a potent PDE1 inhibitor and neuroprotective agent. Synonyms: PDE1-IN-1. Grades: >98%. CAS No. 1160521-50-5. Molecular formula: C29H26FN7O. Mole weight: 507.56.
PDE1-IN-2
PDE1-IN-2 is an inhibitor of PDE1 that has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. Synonyms: PDE1 IN 2; 6-bromo-7-(cyclopentylmethyl)-3-(oxan-4-yl)-[1,2,4]triazolo[4,3-a]pyrazin-8-one. CAS No. 1904611-63-7. Molecular formula: C16H21BrN4O2. Mole weight: 381.27.
PDE5 inhibitor 42
PDE5 inhibitor 42 is a second-generation phosphodiesterase type 5 (PDE5) inhibitor (IC50 = 0.04 nM). Synonyms: PDE5 Inhibitor 42; PDE5-Inhibitor-42; PDE5Inhibitor42; PDE5-IN-42; PDE5 IN 42; PDE5IN42; 1-[1-(2-Ethoxyethyl)-3-ethyl-7-[(4-methylpyridin-2-yl)amino]pyrazolo[4,3-d]pyrimidin-5-yl]piperidine-4-carboxylic acid. Grades: 98%. CAS No. 936449-28-4. Molecular formula: C23H31N7O3. Mole weight: 453.54.
PDE-9 inhibitor
PDE-9 inhibitor is useful for neurodegenerative diseases. Synonyms: PDE 9 inhibitor; PDE9 inhibitor; PDE-9 inhibitor. Grades: >98%. CAS No. 1082743-70-1. Molecular formula: C22H27N5O2. Mole weight: 393.48.
PDE IV-IN-1
An inhibitor of phosphodiesterase IV with potential for the treatment of asthma, COPD or other inflammatory diseases. Synonyms: 9H-Purine, 2-chloro-9-[[3-(cyclopentyloxy)-4-methoxyphenyl]methyl]-6,8-dimethyl-; 2-chloro-9-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-6,8-dimethylpurine. CAS No. 225100-12-9. Molecular formula: C20H23ClN4O2. Mole weight: 386.88.
PDP-EA
PDP-EA, an activator of fatty acid amide hydrolase (FAAH) from plant and mammalian species, is a FAAH activator, which is proposed to enhance amidohydrolase activity of FAAH by reducing negative feedback mechanisms. Synonyms: N-(2-Hydroxyethyl)-2-(3-pentadecylphenoxy)acetamide. Grades: ≥98% by HPLC. CAS No. 861891-72-7. Molecular formula: C25H43NO3. Mole weight: 405.61.
PE 154
PE 154 is a fluorescent inhibitor of both AChE and BChE with IC50 values of 280 pM and 16 nM. PE 154 targets and labels β-amyloid plaques in histochemical analysis. Synonyms: PE 154; PE154; PE-154; 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide. Grades: ≥97% by HPLC. CAS No. 1192750-33-6. Molecular formula: C35H35N5O4. Mole weight: 589.68.
PE859
PE859 is a potent dual inhibitor of tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. Synonyms: 6-[(E)-2-[5-[(E)-2-[2-methoxy-4-(pyridin-2-ylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-1H-indole; PE859; PE-859; PE 859. CAS No. 1402727-29-0. Molecular formula: C28H24N4O2. Mole weight: 448.52.
PEAQX
PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM). Synonyms: NVP-AAM077 tetrasodium hydrate; NVP-AAM 077 tetrasodium hydrate; NVP-AAM077; NVP-AAM 077; NVP-AAM-077; AAM-077; AAM077; AAM 077; PEAQX. Grades: 0.98. CAS No. 459836-30-7. Molecular formula: C17H17BrN3O5P. Mole weight: 454.217.
PEAQX tetrasodium salt
PEAQX is a competitive NMDA receptor antagonist (IC50 = 8 nM) that exhibits >100-fold selectivity for hGluN2A over hGluN2B. It shows anticonvulsant activity in vivo. Synonyms: [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt; 5-[[[(1S)-1-(4-bromophenyl)ethyl]amino]-phosphonatomethyl]quinoxaline-2,3-diolate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 2102348-87-6. Molecular formula: C17H13BrN3Na4O5P. Mole weight: 542.14.
Pegloxenatide
Pegloxenatide is a glucagon-like peptide 1 receptor agonist. Polymer. Synonyms: PEG loxenatide; Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 39,39-diester with L-histidyl-D-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-norleucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-glutaminylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-S-[1-[3-[[2-[[(2S)-2,6-bis(carboxyamino)-1-oxohexyl]amino]ethyl]amino]-3-oxopropyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinamide. CAS No. 2420483-82-3. Molecular formula: C206H317N55O67S.(C2H4O)2n.
Pelitinib
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Synonyms: EKB 569; EKB-569; EKB569; WAY-EKB 569; WAY-EKB569; WAY-EKB-569; CHEBI:38927; NSC729742; WAY-172569; WAY172569; WAY 172569; D05399; D 05399; D-05399. Grades: >98%. CAS No. 257933-82-7. Molecular formula: C24H23ClFN5O2. Mole weight: 467.929.
Pemirolast potassium
Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. Synonyms: BMY26517; BMY 26517; BMY-26517. Grades: >98%. CAS No. 100299-08-9. Molecular formula: C10H7N6O.K. Mole weight: 266.3.
Penbutolol sulfate
Penbutolol is a sympathomimetic drug used to treat mild to moderate high blood pressure by binding to both beta-1 adrenergic receptors and beta-2 adrenergic receptors. Uses: A β-adrenoceptor antagonist. antihypertensive. Synonyms: (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol;sulfuric acid. Grades: ≥95%. CAS No. 38363-32-5. Molecular formula: C18H29NO2. Mole weight: 291.43.
Penfluridol
Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Uses: Antipsychotic agents. Synonyms: TLP-607; TLP 607; TLP607. Grades: >98%. CAS No. 26864-56-2. Molecular formula: C28H27ClF5NO. Mole weight: 523.97.
Pentamidine dihydrochloride
Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. It is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinII), a severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African Trypanosomiasis). Synonyms: Pentamidine dihydrochloride; Pentamidine-d4 2HCl; Pentamidine (dihydrochloride); Pentamidine HCl; Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI); PENTAMIDINE 2HCL; Pentamidinedihydrochloride; MP601205 dihydrochloride; CHEMBL543544; SCHEMBL7060561; HY-B0537A; DTXSID20964635; EX-A1489; 4-[5- (4-carbamimidoylphenoxy) pentoxy]benzenecarboximidamide; dihydrochloride; SW196985-3; A923917; 4,4'-(pentane-1,5-diylbis(oxy))dibenzimidamide 2HCl; Q27280201; 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide dihydrochloride; 4,4'-[Pentane-1,5-diylbis(oxy)]di(benzene-1-carboximidamide)--hydrogen chloride (1/2). Grades: >98%. CAS No. 50357-45-4. Molecular formula: C19H24N4O2.2HCl. Mole weight: 413.34.
Pentolinium Tartrate
Pentolonium tartrate is the tartrate salt form of pentolinium, which is a ganglionic blocking agent and acts as a nicotinic acetylcholine receptor antagonist. It has been used as a ganglionic blocking agent in hypertension. Uses: Pentolonium tartrate has been used as a ganglionic blocking agent in hypertension. Synonyms: 1, 1'-Pentamethylenebis(1-methylpyrrolidiniumtartrate); Ansolysenbitartrate; Tensilest tartrate;1-Methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium;(2R,3R)-2,3,4-trihydroxy-4-oxobutanoate. Grades: 98%. CAS No. 52-62-0. Molecular formula: C23H42N2O12. Mole weight: 538.59.
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