BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Org 37684 | Org 37684 is a 5-HT2C receptor agonist. Synonyms: Org-37684; Org 37684; Org37684; (3S)-3-[(2,3--Dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine hydrochloride. Grades: ≥98% by HPLC. CAS No. 213007-95-5. Molecular formula: C14H19NO2.HCl. Mole weight: 269.77. |  |
| Org 48762-0 | Org 48762-0 is a p38 mitogen-activated protein kinase inhibitor. It can be used for the treatment of autoimmune disease and neuropathic pain. Synonyms: UR-13870, UR 13870, UR13870; 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridyl)-2H-pyrazolo[3,4-b]pyridine; Org 48762-0. Grades: ≥98% by HPLC. CAS No. 755753-89-0. Molecular formula: C24H16F2N4. Mole weight: 398.41. | |
| Org OD 02-0 | Org OD 02-0 is a membrane progesterone receptor agonist. Org OD 02-0 mimics the protective effects of progestin hormones on serum starvation-induced cell death and apoptosis in both granulosa and breast cancer cells without altering caspase 3 activity. Org OD 02-0 significantly increased mitochondrial membrane potential (MMP) in serum starved MB468 cells. Synonyms: 19-Norpregn-4-ene-3,20-dione, 10-vinyl-; 10-Vinyl-19-norprogesterone. Grades: 99%. CAS No. 13258-85-0. Molecular formula: C22H30O2. Mole weight: 326.47. | |
| [Orn8]-Urotensin II (human) trifluoroacetate salt | [Orn8]-Urotensin II is a peptide analog of urotensin II and agonist of the urotensin II receptor. Synonyms: L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5?10)-disulfide, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C63H83N13O18S2·xCF3COOH. Mole weight: 1374.54. | |
| Ornidazole Levo- | Ornidazole Levo-, the levo-isomer of Ornidazole, with good tolerance, and good in vivo distribution, it can be used to prepare anti-anaerobic bacteria infection drugs. Synonyms: (2S)-1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol Ornidazole (Levo-) NCGC00016723-01 CAS-16773-42-5 ZINC563 AC1O71N3 CHEMBL1742294 SCHEMBL15158378. CAS No. 166734-83-4. Molecular formula: C7H10ClN3O3. Mole weight: 219.63. | |
| Orotic acid | Orotic acid is a heterocyclic compound and an acid. It is manufactured in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase, or a cytoplasmic enzyme of pyrimidine synthesis pathway. Synonyms: UK-20349; UK 20349; UK20349. Grades: >98%. CAS No. 65-86-1. Molecular formula: C5H4N2O4. Mole weight: 156.1. | |
| Oroxylin A | Cas No. 480-11-5. | |
| Osanetant | Osanetant is a non-peptide neurokinin 3 (NK3) receptor antagonist. It is developed for the treatment of schizophrenia and other central nervous system (CNS) disorders. Uses: Potential treatment of schizophrenia. Synonyms: SR-142801; SR142801; SR 142801; N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-methylacetamide. Grades: 98%. CAS No. 160492-56-8. Molecular formula: C35H41Cl2N3O2. Mole weight: 606.62. | |
| OSI-027 | mTOR kinase inhibitor OSI-027 is an orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. Synonyms: OSI-027; OSI 027; OSI027. Grades: >98%. CAS No. 936890-98-1. Molecular formula: C21H22N6O3. Mole weight: 406.446. | |
| Otenabant (CP-945,598) | Otenabant, also known as CP-945,598, is a drug which acts as a potent and highly selective CB1 antagonist. It was developed by Pfizer for the treatment of obesity, but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant. Synonyms: Otenabant; CP-945,598; CP-945598; CP 945598; CP945598. Grades: 0.99. CAS No. 686344-29-6. Molecular formula: C25H25Cl2N7O. Mole weight: 510.423. | |
| Otenabant HCl | Otenabant HCl is a selective and high affinity antagonist of CB1 with Ki value of 0.7 nM. Synonyms: 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide hydrochloride; CP945598; CP-945598; CP 945598; CP945,598; CP-945,598; CP 945,598; Otenabant HCl. Grades: >98%. CAS No. 686347-12-6. Molecular formula: C22H18N4O2S3. Mole weight: 466.6. | |
| Otilonium bromide | Otilonium Bromide is an antimuscarinic used as a spasmolytic agent. Synonyms: Otilonium Bromide. Grades: >98%. CAS No. 26095-59-0. Molecular formula: C29H43BrN2O4. Mole weight: 563.57. | |
| OUL 35 | OUL 35 is a PARP-10 inhibitor with IC50 value of 0.329 μM. It can rescue HeLa cells from ARTD10 induced apoptotic cell death. Synonyms: OUL35; OUL 35; OUL-35; NSC39047; NSC 39047; NSC-39047; 4,4'-Oxybis[benzamide];4-(4-Carbamoylphenoxy)benzamide. Grades: ≥98% by HPLC. CAS No. 6336-34-1. Molecular formula: C14H12N2O3. Mole weight: 256.26. | |
| OUP16 | OUP16 is a potent and selective histamine H4 receptor(hH4R) agonist with 40-fold selectivity over the hH3R and superior to its (2S,5S)-configured optical antipode. It expressed in various cells of the immune system. It palys a role in inflammatory, autoimmune, and allergic disorders. Uses: Oup16 palys a role in inflammatory, autoimmune, and allergic disorders. Synonyms: OUP-16; OUP 16; OUP16; Guanidine, N-cyano-N''-methyl-N'-[[(2R,5R)-tetrahydro-5-(1H-imidazol-5-yl)-2-furanyl]methyl]-, rel-. Grades: >98 %. CAS No. 1038917-11-1. Molecular formula: C11H16N6O. Mole weight: 248.29. | |
| OXA-01 | OXA-01 is an mTORC1/mTORC2 inhibitor with IC50 values of 11 and 29 nM, respectively. It exhibits broad antitumor activity in several different human xenograft models of various histologies. Synonyms: 4-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]cyclohexane-1-carboxylic acid. Grades: ≥98%. CAS No. 936889-68-8. Molecular formula: C21H20ClN5O2. Mole weight: 409.9. | |
| OXA 06 dihydrochloride | OXA 06 dihydrochloride is a ROCK inhibitor with IC50 value of 10 nM. It can suppress pMYPT1 and pCofilin levels in non-small cell lung carcinoma cell lines. Synonyms: 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C21H18FN3.2HCl. Mole weight: 404.31. | |
| Oxacillin Sodium Salt | The sodium salt form of Oxacillin which is a narrow-spectrum antibiotic and commonly used for studying the mechanisms of penicillinase resistance. It can be used for penicillin-resistant Staphylococcus infections. Uses: The sodium salt form of oxacillin which is a narrow-spectrum antibiotic and commonly used for studying the mechanisms of penicillinase resistance. Synonyms: 3,3-Dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; (2S,5R,6R)-3,3-Dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt; [2S-(2α,5α,6β)]-3,3-Dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; 5-Methyl-3-phenyl-4-isoxazolyl Penicillin Sodium Salt; BRL 1400; Bactocil; Bactocil Sodium; Bristopen; Cryptocillin; Micropenin; Monosodium Oxacillin; NSC 527712; Oxabel; Oxacillin Sodium Salt; Penicillin P12; Penstapho; Penstaphocid; Prostaphlin; SQ 16423; 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-6-(5-methyl-3;5-methyl-3-phenyl-4-isoxazolylpenicillin,sodium; bactocill; bristopen; brl1400. Grades: > 90%. CAS No. 1173-88-2. Molecular formula: C19H18N3NaO5S. Mole weight: 423.42. | |
| Oxalomalic acid sodium salt | Oxalomalic acid is an inhibitor of both aconitase and NADP-dependent isocitrate dehydrogenase, At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons. Synonyms: Oxalomalic acid trisodium salt. Grades: ≥95%. CAS No. 89304-26-7. Molecular formula: C6H6O8·3Na. Mole weight: 275. | |
| Oxamflatin | Oxamflatin, also known as Metacept-3, an aromatic sulfonamide derivative, is a cell-permeable, potent HDAC inhibitor (IC50= 15.7 nM) with antitumor effect. Synonyms: 2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-; (2E)-N-Hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2-penten-4-ynamide; 2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (E)-; Metacept 3; (E)-N-hydroxy-5-(3-(phenylsulfonamido)phenyl)pent-2-en-4-ynamide; (2E)-5-(3-(phenylsulfonylamino)phenyl)pent-2-ene-4-ynohydroxamic acid. Grades: ≥95%. CAS No. 151720-43-3. Molecular formula: C17H14N2O4S. Mole weight: 342.37. | |
| OXF BD 02 | OXF BD 02 is a first bromodomain of BRD4 inhibitor with IC50 value of 382 nM. It can reduce viability of lung adenocarcinoma cell lines and attenuate proliferation of MV-4-11 leukemia cells. Cell permeable. Synonyms: OXFBD02; OXFBD-02; OXFBD 02; 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol. Grades: ≥98% by HPLC. CAS No. 1429129-68-9. Molecular formula: C18H17NO3. Mole weight: 295.33. | |
| Oxidopamine hydrochloride | Oxidopamine hydrochloride, also called as 6-OHDA, is a selective catecholaminergic neurotoxin that selectively destroy dopaminergic and noradrenergic neurons in the brain. Synonyms: 5-(2-aminoethyl)benzene-1,2,4-triol;hydrochloride 6 Hydroxydopamine 6-Hydroxydopamine 6-OHDA Hydrobromide, Oxidopamine Hydrochloride, Oxidopamine Oxidopamine Oxidopamine Hydrobromide Oxidopamine Hydrochloride. CAS No. 28094-15-7. Molecular formula: C8H12ClNO3. Mole weight: 205.64. | |
| Oxitropium Bromide | Oxitropium bromide, a quaternary ammonium congener of hyoscine with anticholinergic properties, is an mAChR antagonist used for the treatment of asthma and chronic obstructive pulmonary disease. Uses: Parasympatholytics. Synonyms: (8r)-6 beta,7 beta-epoxy-8-ethyl-3 alpha((-)-tropoyl)-1 alpha H, 5 alpha H-tropanium bromide; Ba 253; Ba 253Br; Ba-253; Ba-253Br; oxitropium; oxitropium bromide; oxitropium iodide, (R)-isomer; oxitropium iodide, (S)-isomer; Oxivent; oxytropium bromide; Tersigat; Ventilat. CAS No. 30286-75-0. Molecular formula: C19H26BrNO4. Mole weight: 412.32. | |
| Oxotremorine M | Oxotremorine M is a selective muscarinic acetylcholine receptor agonist used as a parasympathomimetic drug. Uses: Muscarinic agonists. Synonyms: 2-Butyn-1-aminium, N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)-; N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium; N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium. Grades: ≥95%. CAS No. 63939-65-1. Molecular formula: C11H19N2O+. Mole weight: 195.29. | |
| Oxotremorine sesquifumarate | A derivative of Oxotremorine. Oxotremorine is a selective muscarinic acetylcholine receptor agonist. It can be used as a parasympathomimetic drug. Synonyms: 1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone sesquifumarate. Grades: ≥98% by HPLC. CAS No. 17360-35-9. Molecular formula: C12H18N2O.1.5C4H4O4. Mole weight: 380.4. | |
| Oxprenolol hydrochloride | Oxprenolol is an orally bioavailable and non-selective β-adrenergic receptor (β-AR) inhibitor. It exhibits some intrinsic sympathomimetic activity and is used for the treatment of hypertension, angina pectoris, arrhythmias, and anxiety. Uses: Adrenergic beta-antagonists. Synonyms: DL-Alprenolol; DL-Oxprenolol; Oxprenolol HCl; Evinrozit; Ranidrox; 1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol hydrochloride. Grades: ≥98%. CAS No. 6452-73-9. Molecular formula: C15H23NO3·HCl. Mole weight: 301.8. | |
| OXSI 2 | OXSI 2 is a Syk kinase inhibitor with IC50 value of 14 nM. OXSI-2 can inhibit inflammasome assembly, caspase-1 activation, IL-1β processing and release, mitochondrial ROS generation, and pyroptotic cell death. Synonyms: Syk Inhibitor, OXSI-2; OXSI2; OXSI 2. 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide. Grades: ≥98% by HPLC. CAS No. 622387-85-3. Molecular formula: C18H15N3O3S. Mole weight: 353.39. | |
| Oxy-arachidonoyl ethanolamide | Oxy-arachidonoyl ethanolamide is an analog of Δ9-THC, the psychotropic component of marijuana. It has high affinity for the peripheral cannabinoid (CB2) receptor with Ki values of 0.47 and 0.081 μM for hCB1 and hCB2, respectively. Synonyms: oxy-AEA; oxy-Anandamide; N-arachidonoyl-O-(2-hydroxyethyl)hydroxylamine; (5Z,8Z,11Z,14Z)-N-(2-hydroxyethoxy)icosa-5,8,11,14-tetraenamide. Grades: ≥98%. CAS No. 883296-70-6. Molecular formula: C22H37NO3. Mole weight: 363.5. | |
| Oxyclozanide | Oxyclozanide is a salicylanilide anthelmintic used in the treatment and control of Fascioliasis in ruminants mainly domestic animals like Cattle, Sheep and Goats. Uses: Antiplatyhelmintic agents. Synonyms: ICI 46683; ICI-46683; ICI46683; 2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide, 3,3',5,5',6-Pentachloro-2'-hydroxysalicylanilide. Grades: >98%. CAS No. 2277-92-1. Molecular formula: C13H6Cl5NO3. Mole weight: 401.46. | |
| oxyphencyclimine | Oxyphencyclimine is a muscarinic cholinergic receptor antagonist and trade name is called as Daricon. Now it is applicated for the treatment of peptic ulcers and the relief of smooth muscle spasms in gastrointestinal. Synonyms: Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester; 2-Pyrimidinemethanol, 1,4,5,6-tetrahydro-1-methyl-, α-phenylcyclohexaneglycolate (ester); Cyclohexaneglycolic acid, α-phenyl-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester; (±)-Oxyphencyclimine; 1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinemethanol α-phenylcyclohexaneglycolate (ester); Antulcus; Caridan; Naridan; Zamanil. Grades: 98%. CAS No. 125-53-1. Molecular formula: C20H28N2O3. Mole weight: 344.46. | |
| P005091 | P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo. The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Synonyms: P005091; P-005091; P 005091; P5091; P-5091; P 5091. Grades: 0.98. CAS No. 882257-11-6. Molecular formula: C12H7Cl2NO3S2. Mole weight: 348.212. | |
| P1075 | P 1075 is a Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM) by causing relaxation of various isolated animal and human blood vessels. Uses: Vasodilator agents. Synonyms: P-1075; PNU-83757; U-83757; P1075; PNU83757; U83757; P 1075; PNU 83757; U 83757; N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine. Grades: ≥99% by HPLC. CAS No. 60559-98-0. Molecular formula: C12H17N5. Mole weight: 231.3. | |
| P2647 | P2647, also known as Benzquinamide, is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. P2647 binds to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Uses: Antipsychotic agents; antiemetics. Synonyms: P2647; P 2647; P-2647; [3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] acetate; benzquinamide; benzquinamide hydrochloride; benzquinamide, (2alpha,3beta,11balpha)-isomer; Emite-con. CAS No. 63-12-7. Molecular formula: C22H32N2O5. Mole weight: 404.5. | |
| P32/98 hemifumarate | P32/98 is a competitive dipeptidyl peptidase IV (DPP IV) inhibitor exhibiting anti-diabetic activity. Study shows that long-term treatment with P32/98 improves glucose tolerance, insulinemia, beta-cell glucose responsiveness, and peripheral insulin sensitivity. Synonyms: (2S,3S)-2-amino-3-methyl-1-(3-thiazolidinyl)-1-Pentanone (2E)-2-butenedioate (2:1). Grades: ≥98%. CAS No. 251572-86-8. Molecular formula: C9H18N2OS·1/2C4H4O4. Mole weight: 260.4. | |
| p38 MAPK-IN-1 | p38 MAPK-IN-1, a naphthyridine N-oxide, is a novel potent and selective inhibitor of p38 MAPK and it was found to have proper balance between potency and pharmacokinetics and excellent action in a chronic model of arthritis for further study in some sorts. Uses: P38 mapk-in-1 is a novel potent and selective inhibitor of p38 mapk and could be useful in studying some sorts of inflammatory conditions. Synonyms: p38alpha-IN-4; p38alpha IN 4; p38alphaIN4; p38alpha inhibitor 4; p38alpha-inhibitor-4; p38 MAP Kinase Inhibitor XI; P38 MAPK-IN-1; CHEMBL1916344; SCHEMBL2077831; BDBM50357886; HY-12839; HY 12839; HY12839. Grades: 95%. CAS No. 1006378-90-0. Molecular formula: C21H15F2N2O. Mole weight: 349.35. | |
| p38 MAPK-IN-2 | An inhibitor of p38 kinase. Synonyms: Ethanone, 1-[4-[5-(4-chloro-2-fluorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-; 1-[4-[3-(4-chloro-2-fluorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone. CAS No. 635725-16-5. Molecular formula: C20H19ClFN5O2. Mole weight: 415.85. | |
| p38 MAPK Inhibitor | p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase with IC50 value of 35 nM. Synonyms: p38 MAP Kinase Inhibitor; p38 Mitogen-activated Protein Kinase Inhibitor; 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one. Grades: ≥98%. CAS No. 219138-24-6. Molecular formula: C20H13ClFN3O. Mole weight: 365.8. | |
| p38 MAPK Inhibitor IV | p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38α/β MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38??, and p38δ, respectively. Synonyms: p38 MAP Kinase Inhibitor IV; p38 Mitogen-activated Protein Kinase Inhibitor IV; 2,2'-sulfonylbis(3,4,6-trichlorophenol); 3,4,6-trichloro-2-(2,3,5-trichloro-6-hydroxyphenyl)sulfonylphenol. Grades: ≥98%. CAS No. 1638-41-1. Molecular formula: C12H4Cl6O4S. Mole weight: 456.9. | |
| PA 1 dihydrochloride | PA 1 dihydrochloride is a photoswitchable epithelial sodium channel blocker with IC50 values of 90 and 390 nM for αβγ and δβγENaCs in the trans conformation. Synonyms: PA 1 dihydrochloride; PA-1 dihydrochloride; PA1 dihydrochloride; 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C18H16ClN9O.2HCl. Mole weight: 482.75. | |
| PA 452 | PA 452 is a RXR antagonist. It can attenuate cell proliferation and induce apoptosis in MCF-7 breast cancer cells. Synonyms: PA-452; PA 452; PA452; 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 457657-34-0. Molecular formula: C26H37N3O3. Mole weight: 439.59. | |
| PA 8 | PA 8 is a PAC1 receptor antagonist. It attenuates the second phase of formalin-induced nociceptive responses to relieve the inflammatory pain in mice. Synonyms: 2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione; 2-amino-5-(3-methoxy-4-prop-2-enoxyphenyl)-3,6-dihydropyrido[2,3-d]pyrimidine-4,7-dione. Grades: ≥98% by HPLC. CAS No. 878437-15-1. Molecular formula: C17H18N4O4. Mole weight: 342.35. | |
| PACOCF3 | PTK is an analog of palmitic acid. It is a phospholipase A2 inhibitor. Synonyms: 1,1,1-Trifluoro-2-heptadecanone. Grades: ≥99% by HPLC. CAS No. 141022-99-3. Molecular formula: C17H31F3O. Mole weight: 308.43. | |
| PAF-AN-1 | PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist. Synonyms: SDZ 64-412; SDZ-64-412; SDZ64-412. 5-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline; 5-(4'-(3,4,5-trimethoxyphenylethyl)phenyl)-2,3-dihydroimidazo(2,1-a)isoquinoline; SDZ 64-412; SDZ-64-412. CAS No. 115621-84-6. Molecular formula: C28H28N2O3. Mole weight: 440.53. | |
| PAF (C16) | PAF (C16) is an endogenous platelet-activating factor (PAF). It can induce increased vascular permeability. Synonyms: C16-02:0 PC; PC(16:0e/2:0); C16 PAF; 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; PAF C-16. Grades: 98%. CAS No. 74389-68-7. Molecular formula: C26H54NO7P. Mole weight: 523.68. | |
| Pafuramidine | DB289 (pafuramidine maleate; 2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) is a prodrug of DB75 (furamidine dihydrochloride; 2,5-bis(4-guanylphenyl)furan dihydrochloride), an aromatic dication related to pentamidine that has demonstrated good efficacy against African trypanosomiasis, Pneumocystis carinii pneumonia, and malaria, but lacks adequate oral availability. Synonyms: DB289; DB-289; DB 289; Pafuramidine. Grades: >98%. CAS No. 186953-56-0. Molecular formula: C20H20N4O3. Mole weight: 364.4. | |
| (±)-Palmitoylcarnitine chloride | (±)-Palmitoylcarnitine chloride, a long-chain acylcarnitine with both intracellular and extracellular roles, has a wide range of biological actions including the inhibition of protein kinase C and cell membrane disruption. Synonyms: 3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium, chloride; NSC 628323; Palmitoyl-DL-carnitine chloride. CAS No. 6865-14-1. Molecular formula: C23H46ClNO4. Mole weight: 436.07. | |
| Palmitoylisopropylamide | Palmitoyl-N-isopropylamide, a synthetic analog of palmitoyl ethanolamide, is an inhibitor of the FAAH (fatty acid amide hydrolase); pIC50=4.89 for inhibition of [3H]-anandamide metabolism. It displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Synonyms: N-(1-Methylethyl)-hexadecanamide; PIA. CAS No. 189939-61-5. Molecular formula: C19H39NO. Mole weight: 297.52. | |
| Palmitoyl serotonin | Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, an antagonist of FAAH. Study has shown that palmitoyl serotonin attenuates the development of L-DOPA-induced dyskinesia (LID) and enhance of ERK1/2 phosphorylation and FosB/ΔFosB expression in the hemi-parkinsonian mouse model. Synonyms: N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]hexadecanamide; Palmitoylserotonin. Grades: ≥98%. CAS No. 212707-51-2. Molecular formula: C26H42N2O2. Mole weight: 414.6. | |
| Palomid 529 | Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Synonyms: Palomid 529; Palomid-529; Palomid529; P529; P 529; P-529. Grades: >98%. CAS No. 914913-88-5. Molecular formula: C24H22O6. Mole weight: 406.434. | |
| Pam2CSK4 | Pam2CSK4 is a TLR2 agonist and synthetic diacylated lipopeptide. Synonyms: S-[(2R)-2,3-Bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine; L-Lysine, S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-; Pam2Cys-SKKKK; S-((R)-2,3-bis(palmitoyloxy)propyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine. Grades: ≥95%. CAS No. 868247-72-7. Molecular formula: C65H126N10O12S. Mole weight: 1271.83. | |
| Pam2CSK4 Biotin | Pam2CSK4 Biotin is the biotinylated Pam2CSK4. Pam2CSK4, a synthetic diacylated lipopeptide (LP), is a toll-like receptor 2/6 (TLR2/6) agonist, and induces TNF-α production in human mononuclear cells. Synonyms: Pam2CSK4 (Biotin Conjugate); N2-S-((R)-2,3-bis(palmitoyloxy)propyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-N6-(6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanoyl)-L-lysine. Grades: ≥95%. CAS No. 1883545-45-6. Molecular formula: C87H162N14O16S2. Mole weight: 1724.44. | |
| Pam3CSK4 Biotin | Pam3CSK4 Biotin is the biotinylated Pam3CSK4. Pam3CSK4 is a synthetic tripalmitoylated lipopeptide that mimicks the acylated amino terminus of bacterial lipoproteins. Pam3CSK4 is a potent activator of the proinflammatory transcription factor NF-κB and a toll-like receptor 1/2 (TLR1/2) agonist. It stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, and promotes differentiation of naive CD4+ T cells into Th17 cells. Synonyms: (2S, 3Z, 5S, 6Z, 8S, 9Z, 11S, 12Z, 14S, 15Z, 17R)-5, 8, 11-tris(4-aminobutyl)-4, 7, 10, 13, 16-pentahydroxy-2-(4-((Z)-(1-hydroxy-6-((Z)-(1-hydroxy-6-((Z)-(1-hydroxy-5-((3aR, 6S, 6aS)-2-hydroxy-3a, 4, 6, 6a-tetrahydro-1H-thieno[3, 4-d]imidazol-6-yl)pentylidene)amino)hexylidene); Pam3CysSerLys4. Grades: ≥95%. CAS No. 1429504-10-8. Molecular formula: C103H192N14O17S2. Mole weight: 1962.85. | |
| p-Aminosalicylic acid sodium salt dihydrate | p-Aminosalicylic acid sodium salt dihydrate is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.It is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. Uses: Antitubercular agents. Synonyms: Sodium 4-aminosalicylate dihydrate; Parasal sodium; sodium 4-amino-2-hydroxybenzoate dihydrate; Pamisyl sodium; Sodium aminosalicylate; AMINOSALICYLATE SODIUM; TEEBACIN; Nemasol sodium; Paramisan sodium; Sodium P.A.S.; 4-Aminosalicylic acid sodium salt dihydrate;4-amino-2-hydroxybenzoate; dihydrate; AMINOSALICYLATE SODIUM [ORANGE BOOK]; p-Aminosalicylate acid sodium salt dihydrate; FT-0617611; sodium 4-azanyl-2-oxidanyl-benzoate dihydrate;Sodium Aminosalicylate dihydrate for equipment qualification; Benzoic acid, 4-amino-2-hydroxy-, sodium salt, hydrate (1:1:2); Sodium aminosalicylate dihydrate, European Pharmacopoeia (EP) Reference Standard; Sodium aminosalicylate dihydrate for equipment qualification, European Pharmacopoeia (EP) Reference Standard; Sodium Aminosalicylate Dihydrate, Pharmaceutical Secondary Standard; Certified Reference Material. Grades: >98%. CAS No. 6018-19-5. Molecular formula: C7H7NO3.2H2O.Na. Mole weight: 211.15. | |
| Pamoic acid | Pamoic acid is a potent agonist of GPR35 orphan receptors with antinociceptive effects. It was shown to activate ERK and beta-arrestin2. Synonyms: 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid. Grades: 99 %. CAS No. 130-85-8. Molecular formula: C23H16O6. Mole weight: 388.37. | |
| Pancuronium bromide | Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine. Uses: Neuromuscular nondepolarizing agents; nicotinic antagonists. Synonyms: PANCURONIUM BROMIDE; 15500-66-0; Pancuronium dibromide; PavulonMioblock. Grades: >98%. CAS No. 15500-66-0. Molecular formula: C35H60N2O4.2Br. Mole weight: 732.67. | |
| Panomifene | Panomifene is an Estrogen receptor antagonist under the development of Egis Pharmaceuticals. Phase II clinical trials for the treatment of breast cancer was discontinued. Uses: Breast cancer. Synonyms: GYKI-13504; GYKI 13504; GYKI13504; EGIS-5650; EGIS5650; EGIS 5650; PAN; Panomifene; 2-[[2-[4-[(1E)-3,3,3-Trifluoro-1,2-diphenyl-1-propen-1-yl]phenoxy]ethyl]amino]-ethanol; (E)-2-[[2-[4-(3,3,3-Trifluoro-1,2-diphenyl-1-propenyl)phenoxy]ethyl]amino]-ethanol; 2-[[2-[4-[(1E)-3,3,3-Trifluoro-1,2-diphenyl-1-propenyl]phenoxy]ethyl]amino]-ethanol; EGIS 5660; GYKI 13504. Grades: 95%. CAS No. 77599-17-8. Molecular formula: C25H24F3NO2. Mole weight: 427.46. | |
| Pantoprazole sodium hydrate | Pantoprazole sodium hydrate is a proton pump inhibitor which acts as selective inhibiton of H+/K+-ATPase. With antiulcerative effects in vivo, it treats or ameliorates peptic ulcer or irritation of the gastrointestinal tract. Synonyms: sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;hydrate BY 1023 BY-1023 pantoprazole pantoprazole sodium Protonix SK and F 96022 SK and F-96022 SKF-96022. Grades: >98%. CAS No. 164579-32-2. Molecular formula: C16H14F2N3NaO4S. Mole weight: 405.35. | |
| PAOPA | PAOPA is an allosteric modulator of dopamine D2 receptors. It can prevent and reverse behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia. Synonyms: (3R)-2-Oxo-3-[[(2S)-2-Pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide. Grades: ≥98% by HPLC. CAS No. 114200-31-6. Molecular formula: C11H18N4O3. Mole weight: 254.29. | |
| Paprotrain | Paprotrain is a reversible, non-ATP competitive inhibitor of the kinesin MKLP-2 with selectivity over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Paprotrain shows a moderate inhibition activity on DYRK1A (IC50 = 5.5 μM). Synonyms: (Z)-2-(1H-indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile; 2-(1H-indol-3-yl)-3-(pyridin-3-yl)acrylonitrile. CAS No. 57046-73-8. Molecular formula: C16H11N3. Mole weight: 245.28. | |
| PAR1 (1-6) (mouse, rat) trifluoroacetate salt | PAR1 (1-6) is a hexapeptide agonist of proteinase-activated receptor 1 (PAR1) in smooth muscle cells. PAR1 is a high-affinity thrombin receptor expressed in epithelium, neurons, astrocytes, immune cells, and cancer-associated fibroblasts. Synonyms: PAR1-AP; Proteinase-Activated Receptor 1; SFFLRN; TRAP; Thrombin Receptor Activating Peptide. Grades: ≥95%. Molecular formula: C37H54N10O9·xCF3COOH. Mole weight: 782.89. | |
| PAR-2-IN-1 | PAR-2-IN-1 is a protease activated receptor 2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anti-cancer activities. Synonyms: Methyl 8-(tert-butyl)-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate. Grades: 98%. CAS No. 1690176-75-0. Molecular formula: C12H14ClN3O2. Mole weight: 267.71. | |
| PAR3 (1-6) amide (human) trifluoroacetate salt | PAR3 (1-6) amide is a synthetic hexapeptide agonist of proteinase-activated receptor 1 (PAR1) and PAR2. PAR1 is a high-affinity thrombin receptor expressed in epithelium, neurons, astrocytes, immune cells, and cancer-associated fibroblasts. PAR2 is a cell surface receptor of which activation by serine proteinases and some compounds promotes obesity and regulates cellular metabolism. Synonyms: Proteinase-Activated Receptor 3; TFRGAP-NH2. Grades: ≥95%. Molecular formula: C29H46N10O7·xCF3COOH. Mole weight: 646.74. | |
| PAR3 (1-6) amide (mouse) trifluoroacetate salt | PAR3 (1-6) amide is a synthetic hexapeptide agonist of proteinase-activated receptor 1 (PAR1) and PAR2. PAR1 is a high-affinity thrombin receptor expressed in epithelium, neurons, astrocytes, immune cells, and cancer-associated fibroblasts. PAR2 is a cell surface receptor of which the activation by serine proteinases and some compounds promotes obesity and regulates cellular metabolism. Synonyms: SFNGGP amide; SFNGGP-NH2; SFN-NH2. Grades: ≥95%. Molecular formula: C25H36N8O8·xCF3COOH. Mole weight: 576.60. | |
| PAR3 (1-6) (human) | PAR3 (1-6) is a synthetic hexapeptide agonist of proteinase-activated receptor 1 (PAR1). PAR1 is a high-affinity thrombin receptor expressed in epithelium, neurons, astrocytes, immune cells, and cancer-associated fibroblasts. Synonyms: Thrombin Receptor-Like 2 (1-6) (human); L-threonyl-L-phenylalanyl-L-arginyl-glycyl-L-alanyl-L-proline; H-TFRGAP-OH; L-Proline, L-threonyl-L-phenylalanyl-N5-(diaminomethylene)-L-ornithylglycyl-L-alanyl-; L-Threonyl-L-phenylalanyl-N5-(diaminomethylene)-L-ornithylglycyl-L-alanyl-L-proline. Grades: ≥98%. CAS No. 320347-28-2. Molecular formula: C29H45N9O8. Mole weight: 647.72. | |
| PAR4 (1-6) (mouse) trifluoroacetate salt | PAR4 (1-6) is a synthetic hexapeptide agonist of proteinase-activated receptor 4 (PAR4). PAR4 is a thrombin receptor activated by platelet, and acts as a modulator of cellular responses that serve as hallmarks of inflammation. Synonyms: GYPGKF. Grades: ≥95%. Molecular formula: C33H45N7O8·xCF3COOH. Mole weight: 667.75. | |
| Pardoprunox | Pardoprunox, also called as SLV308 or DU-126891, is a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%) that has shown antiparkinsonian potential in animal. Synonyms: 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one2(3H)-benzoxazolone, 7-(4-methyl-1-piperazinyl)-monohydrochloridepardoprunoxSLV-308; SME-308; SLV 308; SME 308; SLV308; SME308. CAS No. 269718-84-5. Molecular formula: C12H15N3O2. Mole weight: 233.27. | |
| Pardoprunox hydrochloride | Pardoprunox hydrochloride is the hydrochloride salt form of Pardoprunox. Pardoprunox, also called as SLV308 or DU-126891, is a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full. Synonyms: 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one;hydrochloride; 2(3H)-benzoxazolone, 7-(4-methyl-1-piperazinyl)-monohydrochloride; pardoprunox; SLV-308; SLV 308; SLV308; SME-308; SME 308; SME308. CAS No. 269718-83-4. Molecular formula: C12H16ClN3O2. Mole weight: 269.73. | |
| Pargyline | Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties(IC50=8.2 nM), and has been found to bind with high affinity to the I2 imidazoline receptor. Uses: Monoamine oxidase b (mao-b) inhibitor. Synonyms: N-benzyl-N-methylprop-2-yn-1-amine. Grades: ≥ 95 %. CAS No. 555-57-7. Molecular formula: C11H13N. Mole weight: 159.23. | |
| Pargyline hydrochloride | Pargyline hydrochloride, a benzene derivative, is an irreversible monoamine oxidase (MAO) inhibitor that is used clinically to treat moderate hypertension but is less effective than TCAs. Uses: Antihypertensive agents. Synonyms: N-benzyl-N-methylprop-2-yn-1-amine;hydrochloride Hydrochloride, Pargyline Pargyline Pargyline Hydrochloride. Grades: >98%. CAS No. 306-07-0. Molecular formula: C11H14ClN. Mole weight: 195.69. | |
| Parogrelil | Parogrelil is a selective and potent PDE III (PDE3) inhibitor with bronchodilating and anti-inflammatory activities. Synonyms: 5-bromo-3-[3-(4-chlorophenyl)propoxy]-4-(pyridin-3-ylmethylamino)-1H-pyridazin-6-one. Grades: 99%. CAS No. 139145-27-0. Molecular formula: C19H18BrClN4O2. Mole weight: 449.73. | |
| Paroxetine maleate | Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki = 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Synonyms: (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate; BRL-29060; FG-7051; BRL 29060; FG 7051; BRL29060; FG7051. Grades: ≥99% by HPLC. CAS No. 64006-44-6. Molecular formula: C19H20FNO3.C4H4O4. Mole weight: 445.44. | |
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