BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Naquotinib mesylate | Naquotinib is irreversible, third-generation, epidermal growth factor receptor (EGFR) inhibitor with IC50 value of 70 nM for NCI-H1650 cell growth. It can covalently bind to and inhibit the activity of mutant forms of EGFR, including the T790M EGFR mutant. So Naquotinib can prevent EGFR-mediated signaling. This may induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. In Dec 2015, Phase-III clinical trials in Non-small cell lung cancer (First-line therapy, Late-stage disease) in Hungary was on-going. In Aug 2016, Phase-I clinical trials in Solid tumours in USA was on-going. Uses: Solid tumours;non-small cell lung cancer. Synonyms: ASP8273 mesilate; ASP 8273 mesilate; ASP-8273 mesilate; 6-Ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(((3R)-1-(1-oxoprop-2-en-1-yl)pyrrolidin-3-yl)oxy)pyrazine-2-carboxamide monomethanesulfonate;448232-80-1 (free base). Grades: 98%. CAS No. 1448237-05-5. Molecular formula: C31H46N8O6S. Mole weight: 658.82. |  |
| N-Arachidonoyl dopamine | N-Arachidonoyl dopamine (NADA) is an endocannabinoid isolated from bovine brain. It acts as an agonist of CB1 and inhibitor of vanilloid TRPV1 receptors. NADA promotes calcium mobilization via Gq-dependent processes and some CB1 receptor trafficking. Synonyms: NADA; (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide. Grades: ≥98%. CAS No. 199875-69-9. Molecular formula: C28H41NO3. Mole weight: 439.6. | |
| N-Arachidonoyl taurine | N-Arachidonoyl taurine is an activator of TRPV1 and TRPV4 with EC50 values of 28 and 21 μM, respectively. Synonyms: N-Arachidonoyltaurine; N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-taurine. Grades: ≥98%. CAS No. 119959-65-8. Molecular formula: C22H37NO4S. Mole weight: 411.6. | |
| N-ArachidonylGABA | N-ArachidonylGABA is first isolated from bovine brain. It was also found to inhibit normal responses to pain in vivo, but has not been fully characterized to date. Synonyms: 4-[[(5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraenyl]amino]butanoic acid; 4-[(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)amino]-butanoic acid. Grades: ≥98% by HPLC. CAS No. 128201-89-8. Molecular formula: C24H39NO3. Mole weight: 389.58. | |
| Naratriptan | Naratriptan, a 5-HT1B/1D receptor agonist, could be used in the treatment of migraine. Uses: Naratriptan is a 5-ht1b/1d receptor agonist that could be used in the treatment of migraine. Synonyms: Naratriptan;Naratriptane;N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide;N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]ethanesulfonamide. Grades: >99%. CAS No. 121679-13-8. Molecular formula: C17H25N3O2S. Mole weight: 335.47. | |
| Narlaprevir | Narlaprevir is a potent, selective, orally bioavailable inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metabolized by the cytochrome P450-3A4 system. Synonyms: SCH-900518; SCH 900518; SCH900518; Narlaprevir. Grades: >98%. CAS No. 865466-24-6. Molecular formula: C36H61N5O7S. Mole weight: 707.96. | |
| Naronapride | Naronapride is a selective 5-HT(4) receptor agonist for gastrointestinal motility disorders. It can accelerate overall colonic transit and tend to accelerate GE and AC emptying and loose stool consistency. In Nov 2016, Renexxion planed two phase III trials for Constipation in USA. Uses: Constipation. Synonyms: ATI-7505; ATI 7505; ATI7505. Grades: 98%. CAS No. 860174-12-5. Molecular formula: C27H41ClN4O5. Mole weight: 537.1. | |
| NAS-181 | NAS-181 is a 5-HT1B receptor antagonist with Ki value of 47 nM. It can increase synthesis and metabolism of 5-HT in the brain following systemic administration and improve passive avoidance retention performance in vivo. Synonyms: NAS-181; NAS 181; NAS181; (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate. Grades: ≥97% by HPLC. CAS No. 1217474-40-2. Molecular formula: C19H26N2O4.2CH3SO3H. Mole weight: 538.63. | |
| Naspm | A poliamine amide as potent Spermidine uptake inhibitor. Synonyms: 1-Naphthylacetyl spermine. Grades: >98%. CAS No. 122306-11-0. Molecular formula: C22H34N4O. Mole weight: 370.53. | |
| Naspm trihydrochloride | Naspm 3HCl is a potent and selective Ca2+ permeable AMPA receptor blocker. Synonyms: Naspm trihydrochloride. Grades: >98%. CAS No. 1049731-36-3. Molecular formula: C22H37Cl3N4O. Mole weight: 479.91. | |
| Nat-20(S)-yne | Nat-20(S)-yne is a potential agonist of hedgehog signaling. Synonyms: (3alpha, 17beta)-17-(1-Hydroxy-1methylpent-4-ynyl)-androst-5-en-3-ol; (3beta)-26,27-Dinorcholest-5-en-24-yne-3,20-diol. Grades: ≥95%. CAS No. 1397692-46-4. Molecular formula: C25H38O2. Mole weight: 370.6. | |
| Nav1.7 blocker 24 | Nav1.7 blocker 24 is a sodium channel blocker with selectivity for the voltage-gated Nav1.7 (pIC50 = 6.75). Synonyms: 2-[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-N-[[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]acetamide. Grades: 99%. CAS No. 1315451-25-2. Molecular formula: C20H16Cl2F3N3O3. Mole weight: 474.26. | |
| Nav1.7-IN-2 | Nav1.7-IN-2, a voltage-gated sodium channels, could be probably effective in chronic pain therapy. IC50: 80 nM. Uses: Nav1.7-in-2 is a voltage-gated sodium channels and could be probably effective in chronic pain therapy. Synonyms: Benzamide, 3-[[4-[3-(4-fluoro-2-methylphenoxy)-1-azetidinyl]-2-pyrimidinyl]amino]-N-methyl-. Grades: 98%. CAS No. 1332295-35-8. Molecular formula: C22H22FN5O2. Mole weight: 407.44. | |
| Nav1.7 inhibitor | Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia. Uses: Nav1.7 inhibitor is a voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia. Synonyms: Nav1.7 inhibitor; NAV1.7-INHIBITOR; 1355631-24-1; 5-Chloro-4-((3,4-dichlorophenoxy)methyl)-2-fluoro-N-(methylsulfonyl)benzamide; 5-Chloro-4-[(3,4-dichlorophenoxy)methyl]-2-fluoro-N-(methylsulfonyl)benzamide; C15H11Cl3FNO4S. Grades: 98%. CAS No. 1355631-24-1. Molecular formula: C15H11Cl3FNO4S. Mole weight: 426.67. | |
| NAV 26 | NAV 26 is a Nav1.7 channel blocker with IC50 value of 370 nM. It can reduce nociceptive behavior in rat models of pain. Synonyms: NAV26; NAV-26; NAV 26; 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide. Grades: ≥98% by HPLC. CAS No. 1198160-14-3. Molecular formula: C22H21F3N2O4. Mole weight: 434.41. | |
| Navarixin | Navarixin is a potent CXC chemokine receptor 2 (CXCR2) antagonist. It can be used for the treatment of Asthma and Chronic obstructive pulmonary disease. In Dec 2011, Merck terminated phase II trial in Chronic obstructive pulmonary disease. Uses: Asthma; chronic obstructive pulmonary disease. Synonyms: SCH 527123; MK 7123; PS 291822; SCH527123; MK7123; PS291822; SCH-527123; MK-7123; PS-291822; (R)-2-hydroxy-N,N-dimethyl-3-((2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)benzamide. Grades: 98%. CAS No. 862464-58-2. Molecular formula: C21H23N3O5.H2O. Mole weight: 428.48. | |
| Naveglitazar | Naveglitazar is a Dual peroxisome proliferator-activated receptor gamma and alpha (PPARgamma and PPARalpha) agonist. Uses: Peroxisome proliferator-activated receptor agonists. Synonyms: 2-methoxy-3-[4-[3- (4-phenoxyphenoxy) propoxy]phenyl]propanoic acid; LY519818; LY-519818; LY 519818; LY-9818; LY9818; LY 9818; CCRIS 9448; Naveglitazar. Grades: ≥98%. CAS No. 476436-68-7. Molecular formula: C25H26O6. Mole weight: 422.47. | |
| Naxifylline | Naxifylline, a xanthine derivative, has been found to be an adenosine A1 receptor antagonist as well as diuretic agent that was once studied in heart failure and hypertension. Synonyms: BG9719; CVT-124; CVT124; CVT 124; Naxifylline; Naxifylline (USAN/INN); DNC000519; D05125; 1,3-dipropyl-8-((1R,2R,4R,5R,6R)-3-oxatricyclo[3.2.1.02,4]octan-6-yl)-3,7-dihydro-1H-purine-2,6-dione. Grades: 98%. CAS No. 166374-49-8. Molecular formula: C18H24N4O3. Mole weight: 344.42. | |
| NBD-556 | NBD-556 is small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding. The CD4-induced conformational change in gp120 is necessary for interaction with CCR5. Synonyms: NBD-556; NBD 556; NBD556. Grades: >98%. CAS No. 333353-44-9. Molecular formula: C17H24ClN3O2. Mole weight: 337.84. | |
| NBD-557 | NBD-557 is a N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction. Synonyms: NBD-557; NBD 557; NBD557. Grades: >98%. CAS No. 333352-59-3. Molecular formula: C17H24BrN3O2. Mole weight: 382.3. | |
| N-Benzylacetamidine hydrobromide | N-Benzylacetamidine is a potent inhibitor of iNOS with IC50 value of 0.20 μM. Synonyms: 1-(Benzylamino)ethaniminium bromide. Grades: ≥98%. CAS No. 186545-76-6. Molecular formula: C9H12N2·HBr. Mole weight: 229.1. | |
| N-Benzylnaltrindole hydrochloride | N-Benzylnaltrindole is a long-acting δ2-selective opioid receptor antagonist. Synonyms: 1'-Benzyl-17-(cyclopropylmethyl)-6,7-didehydro-4,5a-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan hydrochloride. CAS No. 1206487-81-1. Molecular formula: C33H32N2O3·HCl. Mole weight: 541.09. | |
| NBI-27914 | NBI-27914 is antagonist of the CRF1 and CRF2 recepetors (Corticotropin-releasing factor). Synonyms: 5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine; 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; NBI 27914; NBI27914. Grades: >99 %. CAS No. 184241-44-9. Molecular formula: C18H20Cl4N4. Mole weight: 434.186. | |
| NBI 27914 hydrochloride | NBI 27914 hydrochloride is a corticotropin-releasing factor1 receptor antagonist. It can block behavioral seizures in vivo. Synonyms: NBI 27914 hydrochloride; NBI27914 hydrochloride; NBI-27914 hydrochloride; 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride. Grades: ≥99% by HPLC. CAS No. 1215766-76-9. Molecular formula: C18H20Cl4N4.HCl. Mole weight: 470.66. | |
| NBI-30545 | NBI-30545 is a potent corticotropin-releasing factor-1 antagonist with proper lipophilicity (log D=2.78) and good solubility in water (>10mg/mL), and exhibited good plasma and brain exposure when given orally used for stress disorders. Synonyms: 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine; NBI-30545; NBI30545; NBI 30545. Grades: >98%. CAS No. 195054-99-0. Molecular formula: C22H30N4O3. Mole weight: 398.507. | |
| NBI 31772 | NBI-31772 is an insulin-like growth factor-1 binding protein inhibitor. It increases cardiomyocyte proliferation in vivo. Synonyms: NBI-31772; NBI 31772; NBI31772; 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 374620-70-9. Molecular formula: C17H11NO7. Mole weight: 341.27. | |
| NBI-34041 | NBI-34041, also called as SB 723620, is potent and high-affinity corticotropin-releasing factor receptor 1 (CRF1) receptor antagonist. NBI-34041 shows that inhibition of the CRF system is a potential target for developing drug against depression and anxiety disorders. Synonyms: 1-(2,4-dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene; NBI-34041; NBI 34041; NBI34041; SB-723620; SB723620; SB 723620. Grades: >98%. CAS No. 268545-87-5. Molecular formula: C22H26Cl2N4. Mole weight: 417.378. | |
| NBI 35965 hydrochloride | NBI 35965 hydrochloride is a corticotropin-releasing factor receptor 1 antagonist. Some research shows that it has anxiolytic activity. Synonyms: NBI 35965 hydrochloride; NBI35965 hydrochloride; NBI-35965 hydrochloride; (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride. Grades: ≥98% by HPLC. CAS No. 1782228-59-4. Molecular formula: C21H22Cl2N4.HCl. Mole weight: 437.79. | |
| NBI 35965 mesylate | NBI 35965 is a selective corticotropin-releasing factor receptor 1 (CRF1) antagonist without activity against CRF2. It inhibited the stimulation of cAMP induced by sauvagine in CRF1 transfected cells and reduced stress-induced visceral hyperalgesia. Synonyms: (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene monomethanesulfonate; (S)-5-(Cyclopropylmethyl)-1-(2,4-dichlorophenyl)-4-ethyl-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene methanesulfonic acid. Grades: ≥95%. CAS No. 603151-83-3. Molecular formula: C21H22Cl2N4·CH3SO3H. Mole weight: 497.4. | |
| (±)-NBI 74330 | (±)-NBI 74330 is a potent and selective CXCR3 antagonist. Synonyms: rac-NBI-74330; rac NBI 74330; racNBI74330; N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide. CAS No. 473722-68-8. Molecular formula: C32H27F4N5O3. Mole weight: 605.58. | |
| NBI-74330 | NBI-74330 is a small molecule antagonist for CXCR3. Synonyms: NBI-74330; NBI 74330; NBI74330. N-1R-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido(2,3-d)pyrimidin-2-yl)-ethyl-N-pyridin-3-ylmethyl-2-(4-fluoro-3-trifluoromethylphenyl)acetamide. CAS No. 855527-92-3. Molecular formula: C32H27F4N5O3. Mole weight: 605.58. | |
| NBOH-2C-CN hydrochloride | NBOH-2C-CN hydrochloride is a selective 5-HT2A agonist. Synonyms: 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride. Grades: ≥98% by HPLC. CAS No. 1539266-32-4. Molecular formula: C18H20N2O3.HCl. Mole weight: 348.82. | |
| NBQX | This active molecular is an AMPA receptor antagonist which blocks AMPA receptors in 10-20μM concentrations. It is also a Glutamate receptor antagonist. NBQX was found to have anticonvulsant activity in rodent seizure models. This compound has neuroprotective properties. In Nov 1995, NBQX was discontinued preclinical for Stroke in Denmark and in United Kingdom. In Nov 1997, NBQX was discontinued preclinical for Parkinson's disease in USA. Uses: A potent and discriminating antagonist for ampa binding sites. this compound has neuroprotective properties. Synonyms: 6-nitro-2,3-dioxo-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide; NNC 079202; FG 9202; NNC079202; FG9202; NNC-079202; FG-9202. Grades: 98%. CAS No. 118876-58-7. Molecular formula: C12H8N4O6S. Mole weight: 336.28. | |
| NBQX disodium salt | The sodium salt form of NBQX, which has been found to be an AMPA receptor antagonist and could be used as neuroprotective as well as anticonvulsant agent. Synonyms: Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2); Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, disodium salt; NBQX disodium; 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt; 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide Disodium Salt. Grades: ≥98% by HPLC. CAS No. 479347-86-9. Molecular formula: C12H6N4Na2O6S. Mole weight: 380.24. | |
| NCC-149 | NCC149 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor. Synonyms: NCC-149; NCC 149; NCC149; N-hydroxy-3-(1-((phenylthio)methyl)-1H-1,2,3-triazol-4-yl)benzamide. Grades: 96%. CAS No. 1316652-41-1. Molecular formula: C16H14N4O2S. Mole weight: 326.37. | |
| NCX 466 | NCX 466 is a cyclooxygenase inhibiting nitric oxide donors (CINODs). NCX 466 shows higher efficacy in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis camparing to naproxen. Synonyms: (αS)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (5S)-5,6-bis(nitrooxy)hexyl ester. Grades: ≥98% by HPLC. CAS No. 1262956-64-8. Molecular formula: C20H24N2O9. Mole weight: 436.41. | |
| ND-336 | ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase MMP-2, MMP-9, and MMP-14 (Ki = 85, 150, and 120 nM, respectively). It has the potential to treat diabetes that accelerates healing of diabetic wounds. Synonyms: 4-[4-[(2-thiiranylmethyl)sulfonyl]phenoxy]-benzenemethanamine hydrochloride. Grades: ≥95%. CAS No. 1807453-83-3. Molecular formula: C16H17NO3S2·HCl. Mole weight: 371.9. | |
| ND-630 S enantiomer | ND-630 S enantiomer is the S enantiomer of ND-630 which is an acetyl-CoA carboxylase (ACC) inhibitor, and improves metabolic syndrome endpoints, decreases liver steatosis, decreases expression of inflammatory markers and improves fibrosis. Synonyms: 2-[1-[(2S)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid; ND-630 (S enantiomer); ND 630 (S enantiomer); ND630 (S enantiomer). Molecular formula: C28H31N3O8S. Mole weight: 569.63. | |
| NE 100 hydrochloride | NE 100 hydrochloride is a σ1 receptor antagonist with IC50 value of 4.16 nM. It displays antipsychotic activity in vivo. Uses: Antipsychotic agents. Synonyms: NE100 Hydrochloride; NE-100 Hydrochloride; NE 100 Hydrochloride; NE100 HCl; NE-100 HCl; NE 100 HCl; 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 149409-57-4. Molecular formula: C23H33NO2.HCl. Mole weight: 391.97. | |
| (+)-Nebivolol | This active molecular is a β-adrenergic receptor antagonist. Dexnebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and left ventricular failure in Europe. It is highly cardioselective under certain circumstances. In Apr 2015, US FDA approved an ANDA for nebivolol submitted by Amerigen. In Jan 2016, Forest Laboratories and the University of Chicago withdrew a phase II/III trial for Hypertension in patients with chronic obstructive pulmonary disease in USA. Uses: Treatment of hypertension and left ventricular failure. Synonyms: R67138; R-67138; R 67138; Dexnebivolol. (αR,α'R,2R,2'S)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; [2R-[2R*[R*[R*(S*)]]]]-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4- dihydro-2H-1-benzopyran-2-methanol; (S,R,R,R)-Nebivolol; Dexnebivolol; R 67138; d-Nebivolol; '. Grades: 98%. CAS No. 118457-15-1. Molecular formula: C22H25F2NO4. Mole weight: 405.44. | |
| Ned-K | Ned-K, a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist, effectively inhibits Ca2+ oscillations induced by simulated ischemia and reperfusion (sIR) in cardiomyocytes. Synonyms: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[3-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-, (1R,3S)-; (1R,3S)-1-(3-{[4-(2-Cyanophenyl)-1-piperazinyl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid. CAS No. 2250019-90-8. Molecular formula: C31H31N5O3. Mole weight: 521.61. | |
| NEFAZODONE | Nefazodone is a selective serotonin 5-HT2 receptor antagonist. It is an antidepressant under the development of Bristol-Myers Squibb. Its sale was discontinued in some countries due to the rare incidence of hepatotoxicity. Uses: Antidepressant. Synonyms: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one; 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-2H-1,2,4-triazol-3(4H)-one; 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-; BMY-13754; 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one. Grades: 95%. CAS No. 83366-66-9. Molecular formula: C25H32ClN5O2. Mole weight: 470.01. | |
| Neladenoson dalanate | Neladenoson dalanate is a potent adenosine A1 receptor agonist originated by Bayer HealthCare Pharmaceuticals. It is applicated for the treatment of Chronic heart failure. In Apr 2015, Bayer completed the phase II PARSiFAL trial in Chronic heart failure in Germany, Italy, Netherlands and Poland. Uses: Chronic heart failure. Synonyms: BAY 10-67197; BAY 10 67197; BAY-10-67197; BAY1067197; 2-[4-[2-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-3,5-dicyano-6-pyrrolidin-1-ylpyridin-4-yl]phenoxy]ethyl (2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoate. Grades: 98%. CAS No. 1239309-58-0. Molecular formula: C35H34ClN7O4S2. Mole weight: 716.27. | |
| Nelfinavir | An HIV-1 protease inhibitor. It inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Uses: Hiv protease inhibitors. Synonyms: Viracept; AG 1341; AG-1341; AG1341. Grades: ≥98%. CAS No. 159989-64-7. Molecular formula: C32H45N3O4S. Mole weight: 567.78. | |
| Nelonicline | Nelonicline is an Alpha7 nicotinic acetylcholine receptor(nAChR) agonist and Nicotinic acetylcholine receptor agonist. It plays a key role in inflammatory processes, thought to be involved in the pathophysiology of neuropsychiatric diseases. It is potentially useful for the treatment of Alzheimer's diseases. It may be useful to reduce dyskinesias in both early- and later-stage Parkinson's disease. Uses: Nelonicline is potentially useful for the treatment of alzheimer's diseases. it may be useful to reduce dyskinesias in both early- and later-stage parkinson's disease. Synonyms: ABT-126; ABT126; ABT 126; Nelonicline; (3R,4S,5S)-4-((5-Phenyl-1,3,4-thiadiazol-2-yl)oxy)-1-azaadamantane;ABT-126;ABT126;2-(((3R,4r,5S,7s)-1-azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole. Grades: >98 %. CAS No. 1026134-63-3. Molecular formula: C17H19N3OS. Mole weight: 313.42. | |
| Nelotanserin | Nelotanser is Serotonin 2A receptor inverse agonist. In Aug 2016, Axovant Sciences initiated a phase-II clinical trial in Lewy body disease in USA. Uses: Lewy body disease. Synonyms: 1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea;APD125; APD-125; APD 125; Nelotanserin. Grades: 98%. CAS No. 839713-36-9. Molecular formula: C18H15BrF2N4O2. Mole weight: 437.24. | |
| Nemadipine A | Nemadipine A is a cell-permeable L-type calcium channel blocker. It was shown to reduce the expression of survivin, an inhibitor of the apoptosis protein (IAP) family of proteins, sensitizing TRAIL-resistant cancer cells to TRAIL. Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(pentafluorophenyl)-3,5-pyridinedicarboxylic acid diethyl ester. Grades: ≥98%. CAS No. 54280-71-6. Molecular formula: C19H18F5NO4. Mole weight: 419.3. | |
| Nemonapride | Nemonapride, an atypical antipsychotic approved in Japan for the treatment of schizophrenia, is a highly potent dopamine D2-like receptor antagonist, which is selective over D1-like receptors (Ki= 0.1 and 740 nM for D2-like and D1-like receptors respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM). Uses: Antipsychotic agents. Synonyms: rel-5-Chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phennylmethyl)-3-pyrrolidinyl]benzamide; cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phennylmethyl)-3-pyrrolidinyl]benzamide; Emilace; Emonapride; YM 09151; YM09151; YM-09151; YM 09151-2; Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, rel-; Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, cis-. Grades: ≥99% by HPLC. CAS No. 75272-39-8. Molecular formula: C21H26ClN3O2. Mole weight: 387.91. | |
| Neostigmine Iodide | This active molecular is a reversible acetylcholinesterase inhibitor as a parasympathomimetic compound under the development of Flamel Technologies. Neostigmine Iodide is used to improve muscle tone in people with myasthenia gravis and it can also be used to reverse the effects of non-depolarizing muscle relaxants at the end of the surgery. Neostigmine Iodide also can be applicated for urinary retention resulting from general anesthesia and to treat curariform drug toxicity. Uses: Myasthenia gravis; neuromuscular blockade. Synonyms: [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;iodide;SB-24; TL-1321; SB 24; TL 1321; SB24; TL1321. Grades: 98%. CAS No. 1212-37-9. Molecular formula: C12H19IN2O2. Mole weight: 350.20. | |
| Neostigmine Methylsulfate | Neostigmine methyl sulfate is a cholinesterase inhibitor used in the treatment of myasthenia gravis, can not cross the blood-brain barrier. It can be used for gastrointestinal relaxation, constipation, urinary retention, myasthenia gravis and infertility after birth, etc.; it can also be used for the rescue of atropine overdose poisoning. Uses: Cholinergic. Synonyms: Hodostin; Neostigmeth. Grades: ≥98%. CAS No. 51-60-5. Molecular formula: C13H22N2O6S. Mole weight: 334.39. | |
| Nesbuvir | Nesbuvir, a novel selective nonstructural protein 5B (NS5B) polymerase inhibitor, acts as candidate for HCV treatment. It was reduced across different isolates. Synonyms: HCV-796; HCV 796; VB-19796 ; VB19796; HCV796; Nesbuvir. Grades: >98%. CAS No. 691852-58-1. Molecular formula: C22H23FN2O5S. Mole weight: 446.49. | |
| NESS 0327 | NESS 0327 is a potent and selective cannabinoid (CB) receptor antagonist with selectivity for CB1 receptor over CB2 receptor with Ki values of 0.35 pM and 21 nM, respectively. It shows more potent efficacy for CB1 over SR 141716A. Synonyms: NESS 0327; 494844-07-4; NESS-0327; X1BQI2J97I; NESS0327; UNII-X1BQI2J97I; CHEMBL376700; Benzo(6,7)cyclohepta(1,2-C)pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-; 8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide; N-(Piperidin-1-yl)-8-chloro-1-(2',4'-dichlorophenyl)-1,4,5,6-tetrahydrobenzo(6,7)cyclohepta(1,2-C)pyrazole-3-carboxamide. Grades: ≥98%. CAS No. 494844-07-4. Molecular formula: C24H23Cl3N4O. Mole weight: 489.8. | |
| N-Ethyl-p-menthane-3-carboxamide | WS 3 is a cooling agent that acts as an agonist at TRPM8 receptors (EC50 = 3.7 μM). Uses: Cooling agent. Synonyms: WS 3; WS3; WS-3; N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide; N-Ethyl-p-menthane-3-carboxamide; Ethyl menthane carboxamide. Grades: ≥99% by HPLC. CAS No. 39711-79-0. Molecular formula: C13H25NO. Mole weight: 211.34. | |
| Neuropeptide SF (mouse, rat) | Neuropeptide SF (mouse, rat) is a neuropeptide FF receptor agonist (Ki= 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). NPSF may play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH. Synonyms: Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2. CAS No. 230960-31-3. Molecular formula: C40H65N13O10. Mole weight: 888.03. | |
| Neuropeptide Y 13-36 (porcine) | Neuropeptide Y 13-36 (porcine) is a selective neuropeptide Y2 receptor agonist (Ki = 0.18 nM). It mimics the effects of NPY at presynaptic receptors in vas deferens. Synonyms: H-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2. CAS No. 113662-54-7. Molecular formula: C135H209N41O36. Mole weight: 2982.36. | |
| Neuropeptide Y (porcine) | Neuropeptide Y (porcine) is a widely distributed endogenous neuropeptide involved in regulation of circadian rhythms, sexual functioning, anxiety and stress response, and regulation of food intake (Ki= 0.17, 0.04 nM at human and Y2 respectively). It inhibits cholecystokinin- and secretin-stimulated pancreatic secretion. Synonyms: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2. CAS No. 83589-17-7. Molecular formula: C190H287N55O57. Mole weight: 4254. | |
| Neuropeptide Y (scrambled) | Neuropeptide Y (scrambled) is the control peptide for neuropeptide Y (NPY). Neuropeptide Y is a widely distributed endogenous neuropeptide involved in the control of food intake, sexual behavior and blood pressure. Synonyms: SKPQRDANREPTRYAIYDYSNPDIELHYLRPAYALG-NH2. Molecular formula: C190H287N55O57. Mole weight: 4253.7. | |
| Neutrophil Elastase Inhibitor | Neutrophil elastase inhibitor is an inhibitor that selectively targets the binding domain of neutrophil elastase, a serine proteinase secreted by neutrophils and macrophages during inflammation. It is potentially used for lung disease treatment. Uses: Protease inhibitors. Synonyms: 1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile. Grades: ≥95%. CAS No. 1448314-31-5. Molecular formula: C16H11N3O. Mole weight: 261.3. | |
| Nexturastat A | Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Nexturastat A possesses antiproliferative effects against melanoma cells. Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy. Synonyms: Nexturastat A. Grades: 0.98. CAS No. 1403783-31-2. Molecular formula: C19H23N3O3. Mole weight: 341.411. | |
| NF 023 | NF 023 is a subtype-selective P2X1 receptor antagonist with IC50 value of 0.21μM for human P2X1. Synonyms: NF 023; NF023; NF-023; 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt. Grades: ≥98% by HPLC. CAS No. 104869-31-0. Molecular formula: C35H20N4Na6O21S6. Mole weight: 1162.86. | |
| NF 110 | NF 110 is a P2X3 receptor antagonist with Ki value of 36nM. It shows antitumor activity against several tumor types. Synonyms: NF 110; NF110; NF-110; 4, 4', 4'', 4'''-[Carbonylbis[imino-5, 1, 3-benzenetriylbis (carbonylimino) ]]tetrakisbenzenesulfonic acid tetrasodium salt. Grades: ≥95%. CAS No. 111150-22-2. Molecular formula: C41H28N6Na4O17S4. Mole weight: 1096.9. | |
| NF 157 | NF 157 is a P2Y11 receptor antagonist with IC50 value of 463 nM. It inhibits NAD+-induced activation of human granulocytes. Synonyms: NF157; NF 157; NF-157. 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt. Grades: ≥96% by HPLC. CAS No. 104869-26-3. Molecular formula: C49H28F2N6Na6O23S6. Mole weight: 1437.08. | |
| NF 279 | NF 279 is a potent and selective P2X1 antagonist with IC50 value of 19 nM. Synonyms: NF 279; NF279; NF-279; 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt. Grades: ≥98% by HPLC. CAS No. 202983-32-2. Molecular formula: C49H30N6Na6O23S6. Mole weight: 1401.1. | |
| NF 340 | NF 340 is a selective P2Y11 antagonist. It shows competitive antagonism against ATPγS with pIC50 values of 6.43 and 7.14 in Ca2+ and cAMP assays respectively. Synonyms: NF 340; NF-340; NF340; 4, 4'- (Carbonylbis (imino-3, 1- (4-methyl-phenylene)carbonylimino))bis (naphthalene-2, 6-disulfonic acid) tetrasodium salt. Grades: ≥95% by HPLC. CAS No. 202982-98-7. Molecular formula: C37H26N4Na4O15S4. Mole weight: 986.84. | |
| NF 449 | NF449 is a selective P2X1 receptor antagonist. It can be used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism. NF449 also acts as a Gsα-selective antagonist. Synonyms: NF449; NF 449; NF-449. 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt. Grades: ≥90% by HPLC. CAS No. 627034-85-9. Molecular formula: C41H24N6Na8O29S8. Mole weight: 1505.06. | |
| NF 546 | NF 546 is a P2Y11 agonist with pEC50 value of 6.27. It can stimulate release of interleukin-8 from human monocyte-derived dendritic cells. Synonyms: NF 546; NF546; NF-546; 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt. Grades: ≥95% by HPLC. CAS No. 1006028-37-0. Molecular formula: C47H44N6Na4O17P4. Mole weight: 1180.74. | |
| NF-κB Activation Inhibitor III | NF-κB activation inhibitor III inhibits TNF-α-induced MMP-9 protein expression via blocking NF-κB activity. It has been used to suppress invasion and metastasis of tumor cells. Uses: Matrix metalloproteinase inhibitors. Synonyms: SM-7368; SM 7368; SM7368; 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide. Grades: ≥99%. CAS No. 380623-76-7. Molecular formula: C10H5ClN4O5S. Mole weight: 328.7. | |
| NF-κB Control | NF-κB Control is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit. It acts as a negative control of NF-κB signaling pathway. Synonyms: SN50M. Grades: ≥95%. CAS No. 201608-17-5. Molecular formula: C123H215N33O30S. Mole weight: 2668.3. | |
| NG 52 | NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 μM, respectively). It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 μM). It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases. Synonyms: Compound 52; NG-52; NG52. Grades: >98%. CAS No. 212779-48-1. Molecular formula: C16H19ClN6O. Mole weight: 346.81. | |
| NG-amino-L-arginine hydrochloride | NG-amino-L-arginine is a nitric oxide synthase (NOS) inhibitor that inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively. It caused concentration-dependent, competitive, and stereoselective antagonism of acetylcholine-elicited relaxation and cyclic GMP accumulation. Synonyms: L-NAA; Nomega-amino-L-arginine hydrochloride; (2S) -2-amino-5-[[amino (hydrazinyl) methylidene]amino]pentanoic acid hydrochloride. Grades: ≥97%. CAS No. 1031799-40-2. Molecular formula: C6H15N5O2·HCl. Mole weight: 225.7. | |
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