BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| MLN120B | MLN120B is a potent and effective IKKbeta inhibitor. It is currently being explored for treatment of inflammatory diseases such as COPD and asthma. Synonyms: MLN-120B; MLN120B; MLN 120B. Grades: >98%. CAS No. 783348-36-7. Molecular formula: C19H15ClN4O2. Mole weight: 366.8. |  |
| MLN2480 | MLN2480 is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf. Synonyms: TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; AMG 2112819; AMG2112819; AMG-2112819. Grades: >98%. CAS No. 1096708-71-2. Molecular formula: C17H12Cl2F3N7O2S. Mole weight: 506.29. | |
| MLN8054 | MLN8054 is an aurora kinase inhibitor MLN8054, which is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. Synonyms: MLN8054; MLN 8054; MLN-8054. CAS No. 869363-13-3. Molecular formula: C25H15ClF2N4O2. Mole weight: 476.86. | |
| ML RR-S2 CDA | ML RR-S2 CDA, a synthetic CDN-derivative molecule, compared to endogenous and pathogen-derived CDNs, as a attractive compound for anticancer clinical development, it improves both stability and lipophilicity, promoting significantly increased STING signal. Synonyms: 2',3'-c-di-AM(PS)2(Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-, cyclic nucleotide; (R,R)-(2',3')c-diAM(PS)2; (2',3')-Rp,Rp-c-diAMPSS; dithio-(RP, RP)-[cyclic[A(2',5')pA(3',5')p]]; ML RR-S2 CDA (STING-Inducer-1). Grades: ≥95%. CAS No. 1638241-89-0. Molecular formula: C20H24N10O10P2S2. Mole weight: 690.54. | |
| MLS 1547 | MLS 1547 is a dopamine D2 receptor agonist. It may be used in the combination with antipsychotic drugs. Synonyms: MLS 1547; MLS1547; MLS-1547; 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Grades: ≥98% by HPLC. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.83. | |
| MM-102 Trifluoroacetate | MM102 is a WDR5/MLL interaction inhibitor with IC50 value of 2.4 nM. It can inhibit cell growth and induce apoptosis in leukemia cells harbouring MLL1 fusion proteins. Synonyms: MM 102; MM102; MM-102; 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate. Grades: ≥98% by HPLC. CAS No. 1883545-52-5. Molecular formula: C35H49F2N7O4.CF3CO2H. Mole weight: 783.83. | |
| MM 11253 | MM 11253 is a RARγ antagonist. It can block the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Synonyms: MM 11253; MM-11253; MM11253. 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 345952-44-5. Molecular formula: C28H30O2S2. Mole weight: 462.67. | |
| MM-206 | MM-206 is a cell-permeable STAT3 inhibitor. Synonyms: 2,3,4,5,6-Pentafluoro-N-(4-hydroxy-3-phenylsulfanylnaphthalen-1-yl)benzenesulfonamide. Grades: ≥98%. CAS No. 1809581-87-0. Molecular formula: C22H12F5NO3S2. Mole weight: 497.5. | |
| MM 77 dihydrochloride | MM 77 dihydrochloride is a 5-HT1A receptor antagonist. Uses: Serotonin 5-ht1 receptor antagonists. Synonyms: MM 77 dihydrochloride; MM77 dihydrochloride; MM-77 dihydrochloride; 1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine dihydrochloride. Grades: ≥95%. CAS No. 159187-70-9. Molecular formula: C19H27N3O3.2HCl. Mole weight: 418.36. | |
| MMP-13 Inhibitor | MMP-13 Inhibitor is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 value of 8 nM. Synonyms: Collagenase-3 Inhibitor; Matrix Metalloproteinase-13 Inhibitor; 4,6-Pyrimidinedicarboxamide; N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide. Grades: ≥98%. CAS No. 544678-85-5. Molecular formula: C22H20F2N4O2. Mole weight: 410.4. | |
| MMP-2 Inhibitor I | MMP-2 Inhibitor I is a reversible inhibitor of matrix metalloproteinase 2 (MMP-2) with Ki value of 1.6 μM. It attenuates cancer cell migration via inhibition of MMP-2. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor I; cis-9-Octadecenoyl-N-hydroxylamide; Oleylhydroxamate; N-Hydroxyoleamide; OA-Hy; Oleoyl-N-hydroxylamide. Grades: ≥98%. CAS No. 10335-69-0. Molecular formula: C18H35NO2. Mole weight: 297.5. | |
| MMP-2 Inhibitor II | MMP-2 Inhibitor II is an irreversible inhibitor of matrix metalloproteinase-2 (MMP-2) with Ki value of 2.4 μM. It also less potently inhibits MMP-1 and MMP-7. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor II; (4- (4- (Methanesulfonamido) phenoxy) phenylsulfonyl) methyloxirane. Grades: ≥98%. CAS No. 869577-51-5. Molecular formula: C16H17NO6S2. Mole weight: 383.4. | |
| MMP-2/MMP-9 Inhibitor I | MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 310 and 240 nM, respectively. It blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor I; 3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanoic acid. Grades: ≥99%. CAS No. 193807-58-8. Molecular formula: C21H19NO4S. Mole weight: 381.4. | |
| MMP-2/MMP-9 Inhibitor II | MMP-2/MMP-9 inhibitor II is a potent inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 17 and 30 nM, respectively. It was shown to suppress lung colonization of Lewis lung carcinoma cells and inhibit tumor-induced angiogenesis, tumor growth, and liver metastasis in mouse models. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II; (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide. Grades: ≥98%. CAS No. 193807-60-2. Molecular formula: C21H20N2O4S. Mole weight: 396.46. | |
| MMP-2/MMP-9 Inhibitor III trifluoroacetate salt | MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 10-20 μM for both. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥95%. Molecular formula: C52H71N13O14S2·xCF3COOH. Mole weight: 1166.33. | |
| MMP-3 Inhibitor | MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with Ki value of 95 nM. Synonyms: Matrix Metalloproteinase-3 Inhibitor; N-acetyl-L-arginyl-L-cysteinyl-glycyl-L-valyl-L-prolyl-L-isoasparagine. Grades: ≥95%. CAS No. 158841-76-0. Molecular formula: C27H46N10O9S. Mole weight: 686.78. | |
| MMP-3 Inhibitor VIII | MMP-3 inhibitor VIII is a cell-permeable inhibitor of matrix metalloproteinase-3 (MMP-3) with Ki value of 23 nM. It also inhibits mouse macrophage metalloelastase MME/MMP-12. Synonyms: Matrix Metalloproteinase-3 Inhibitor VIII; Stromelysin-1 Inhibitor VIII; N-Hydroxy-2(R)-{[(4-methoxyphenyl)sulfonyl]-[benzylamino]}-4-methylpentanamide. Grades: ≥95%. CAS No. 208663-26-7. Molecular formula: C20H26N2O5S. Mole weight: 406.5. | |
| MMP-8 Inhibitor I | MMP-8 Inhibitor I is a selective and cell-permeable inhibitor of matrix metalloproteinase-8 (MMP-8) with IC50 value of 4 nM. MMP-8 is a neutrophil collagenase that cleaves interstitial collagens. MMP-8 is associated with diseases including arthritis, cancer, osteoporosis and arteriosclerosis. Synonyms: Matrix Metalloproteinase-8 Inhibitor I; N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide. Grades: ≥95%. CAS No. 236403-25-1. Molecular formula: C17H18N2O5S. Mole weight: 362.4. | |
| MMP-9 Inhibitor I | MMP-9 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinase-9 (MMP-9) with IC50 value of 5 nM, respectively. Synonyms: Matrix Metalloproteinase-9 Inhibitor I; 2-[Benzyl(4-methoxyphenylsulfonyl)amino]-3-methyl-5-(diethylaminomethyl)benzohydroximic acid. Grades: ≥95%. CAS No. 1177749-58-4. Molecular formula: C27H33N3O5S. Mole weight: 511.6. | |
| MMP-9/MMP-13 Inhibitor I | MMP-9/MMP-13 inhibitor I is a selective and cell-permeable inhibitor of matrix metalloproteinases MMP-9/MMP-13 with IC50 values of 0.9 nM for both. It also less potently inhibits MMP-1, MMP-3, and MMP-7. Synonyms: Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I; N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide. Grades: ≥98%. CAS No. 204140-01-2. Molecular formula: C25H25N3O6S. Mole weight: 495.6. | |
| MMP Inhibitor II | MMP Inhibitor II is an inhibitor of matrix metalloproteinase MMP-1/MMP-3/MMP-7/MMP-9 with IC50 values of 24, 18.4, 30 and 2.7 nM, respectively. Synonyms: Matrix Metalloproteinase Inhibitor II; NHDDPC; PG 117025; PGE 4410186; N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide. Grades: ≥95%. CAS No. 203915-59-7. Molecular formula: C21H27N3O8S2. Mole weight: 513.6. | |
| MMP Inhibitor I trifluoroacetate salt | MMP inhibitor I is an inhibitor of matrix metalloproteinase MMP-1/MMP-2/MMP-3 with IC50 values of 1.3, 30, and 150 μM, respectively. Synonyms: FN 439; Matrix Metalloproteinase Inhibitor I. Grades: ≥95%. Molecular formula: C23H35N6O6·xCF3COOH. Mole weight: 491.56. | |
| MMPIP hydrochloride | MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM). It was demonstrated to reduce pain responses and affective/cognitive impairments in neuropathic pain conditions. Synonyms: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-C]pyridin-4(5H)-one hydrochloride. Grades: ≥98%. CAS No. 1215566-78-1. Molecular formula: C19H15N3O3·HCl. Mole weight: 369.8. | |
| MMPX | MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM). It causes an increase in cGMP but not cAMP, prolonging signal transduction for cGMP-dependent pathways. Synonyms: 8-Methoxymethyl-3-isobutyl-1-methylxanthine; MMPX; 8-METHOXYMETHYL-1-METHYL-3-(2-METHYLPROPYL)XANTHINE; 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE; 8-METHOXYMETHYL-3-ISOBUTYRYL-1-METHYLXANTHINE; 8-METHOXYMETHYL-IBMX. CAS No. 78033-08-6. Molecular formula: C12H18N4O3. Mole weight: 266.3. | |
| MNI-caged-NMDA | MNI-caged-NMDA, NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group, is used as a ligand for glutamate receptor subtypes in the isolation of post-synaptic receptor activation. Synonyms: (R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid. Grades: ≥99% by HPLC. CAS No. 1227675-52-6. Molecular formula: C14H17N3O6. Mole weight: 323.3. | |
| Mocetinostat | Mocetinostat is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated with a poor prognosis. Synonyms: MGCD-0103; MGCD 0103; MGCD0103. Grades: >98%. CAS No. 726169-73-9. Molecular formula: C23H20N6O. Mole weight: 396.454. | |
| Modaline sulfate | Modaline sulfate, also called as W3207B, is an active inhibitor of monoamine oxidase to treat depression. Synonyms: 2-methyl-3-piperidin-1-ylpyrazine;sulfuric acid MODALINE SULFATE Modaline (sulfate) 2-Methyl-3-piperidinopyrazine monosulfate 2856-75-9 UNII-NH3315AI6E NSC-89277 W3207B W 3207B W 3207 B Pyrazine, 2-methyl-3-piperidino-, sulfate Modaline sulfate [USAN] M 7. CAS No. 2856-75-9. Molecular formula: C10H17N3O4S. Mole weight: 275.32. | |
| Modipafant | This active molecular is a dihydropyridine Platelet-Activating Factor (PAF) antagonist under the development of Pfizer. In Sep 2015, treatment for Asthma in USA was discontinued. In Sep 2015, Phase-I clinical trials in Dengue in USA was on-going. Uses: Dengue;asthma. Synonyms: UK-80067; UK 80067; UNII-1DMI0E5023;122957-06-6;UK80067;AC1MILSU;(R)-ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate. Grades: 95%. CAS No. 122957-06-6. Molecular formula: C34H29ClN6O3. Mole weight: 605.09. | |
| Moexipril HCl | Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 μM, which is used for the treatment of hypertension and congestive heart failure. Uses: Angiotensin-converting enzyme inhibitors. Synonyms: CI-906, PD-109452-2; CI 906, PD 109452-2; CI906, PD109452-2. Grades: >98%. CAS No. 82586-52-5. Molecular formula: C27H35ClN2O7. Mole weight: 535.03. | |
| Mofegiline HCl | The hydrochloride salt form of Mofegiline which is an irreversible inhibitor of MAO-B and was studied about its potential effect against Parkinson's disease and Alzheimer's disease. IC50: 3.6 nM. Uses: The hydrochloride salt form of mofegiline which is an irreversible inhibitor of mao-b and was studied about its potential effect against parkinson's disease and alzheimer's disease. Synonyms: Mofegiline hydrochloride;Mofegiline HCl. Grades: ≥ 95.0%. CAS No. 120635-25-8. Molecular formula: C11H13F2N.HCl. Mole weight: 233.69. | |
| Molindone | Molindone is dopamine D2 receptor antagonist which can be used in the treatment of schizophrenia. Molindone can block the effects of dopamine in the brain, leading to diminished psychoses. Uses: Schizophrenia. Synonyms: Molindone, Moban, Molindonum; 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one;5622-65-8(hydrochloride). Grades: 98%. CAS No. 7416-34-4. Molecular formula: C16H24N2O2. Mole weight: 276.37. | |
| Molindone hydrochloride | Molindone hydrochloride, an indole derivative, as an antipsychotic agent it blocks the effects of dopamine in the brain which can be used for the treatment of schizophrenia. Uses: Antipsychotic agents. Synonyms: 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one;hydrochloride Endo Brand of Molindone Hydrochloride Hydrochloride, Molindone Moban Molindone Molindone Hydrochloride Molindone Monohydrochloride Monohydrochloride, Molindone. CAS No. 15622-65-8. Molecular formula: C16H25ClN2O2. Mole weight: 312.83. | |
| MONNA | MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM) that does not interact with anion channels such as CFTR, ClC-2 and bestrophin 1. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Synonyms: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid. Grades: ≥98% by HPLC. CAS No. 1572936-83-4. Molecular formula: C18H14N2O5. Mole weight: 338.31. | |
| Moricizine | Moricizine, a Phenothiazine derivative, is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. And moricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances. Synonyms: ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate EN 313 EN-313 EN313 Ethmozin Ethmozine Etmozin Hydrochloride, Moricizine Moracizin Moracizine Moricizine Moricizine Hydrochloride. CAS No. 31883-05-3. Molecular formula: C22H25N3O4S. Mole weight: 427.52. | |
| Morinidazole | Morinidazole is a novel 5-nitroimidazole antimicrobial drug. It undergoes extensive metabolism in humans via N+-glucuronidation and sulfation. It is used for the treatment of bacterial infections including pelvic inflammatory disease and appendicitis caused by anaerobic bacteria. It was developed by Jiangsu Hansoh Pharmaceutical Co., Ltd. and has been listed by China Food and Drug Administration (CFDA) on February 24, 2014. Uses: Morinidazole is used for the treatment of bacterial infections including pelvic inflammatory disease and appendicitis caused by anaerobic bacteria. Synonyms: alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol. Grades: >98 %. CAS No. 92478-27-8. Molecular formula: C11H18N4O4. Mole weight: 270.29. | |
| Morphothiadin | Morphothiadin is a potent inhibitor of Hepatitis B virus (HBV). It is active against both wild-type and adefovir-resistant HBV with IC50 value of 12 nM. Morphothiadin exhibits strong inhibitory effects against virus DNA in mouse models. Synonyms: GLS4; Ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate. Grades: 99.84%. CAS No. 1092970-12-1. Molecular formula: C21H22BrFN4O3S. Mole weight: 509.39. | |
| Moxifloxacin | Moxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. The antibacterial spectrum of moxifloxacin includes all major upper and lower respiratory tract pathogens; it is one of the most active fluoroquinolones against pneumococci, including penicillin- and macrolide-resistant strains. Moxifloxacin has limited phototoxic potential. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%. Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. Moxifloxacin possibly stimulates lipid peroxidation and enhances phagocytosis, as depicted by MDA production and survival prolongation, without being toxic as depicted by white blood cell count. Synonyms: Avelox. Grades: >98%. CAS No. 151096-09-2. Molecular formula: C21H24FN3O4. Mole weight: 401.43. | |
| Moxisylyte hydrochloride | Moxisylyte hydrochloride is alpha 1-adrenoceptor antagonist. It can vasodilates cerebral vessels without reducing blood pressure. It is used as peripheral vasodilator. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine. It is used as sympathomimetic agents. It has been listed. Uses: Moxisylyte hydrochloride is used as peripheral vasodilator. it is also used as sympathomimetic agents. Synonyms: Carvacrol,5-[2-(dimethylamino)ethoxy]-, acetate (ester), hydrochloride (8CI);Phenol,4-[2-(dimethylamino)ethoxy]-2-methyl-5-(1-methylethyl)-, acetate (ester),hydrochloride (9CI);4-(2-Dimethylaminoethoxy)-5-isopropyl-2-methylphenyl acetatehydrochloride;Opilon hydrochloride; (2- (4-acetoxy-2-isopropyl-5-methylphenoxy) ethyl) dimethylaminehydrochloride; 5- (2- (N, N-dimethylamino) ethoxy) carvacrolacetatehydrochloride; Arlitene; Vasoklin; Moxisylyte HCl;[4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] acetate;hydrochloride;Thymoxamine hydrochloride. Grades: >98 %. CAS No. 964-52-3. Molecular formula: C16H26ClNO3. Mole weight: 315.84. | |
| Moxonidine hydrochloride | Moxonidine hydrochloride is a mixed agonist of α2-adrenergic receptor (α2AR) and imidazoline-1 receptor(I1R). Its Ki values is 4.2±3.2 nmol/L, 13.0±4.2 nmol/L, 9.5±4.1 nmol/L and 15.6±9.8 nmol/L for I1R, α2AAR, α2BAR and α2CAR, respectively. It is used as antihypertensive agent. It displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. It reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM. It has shown low affinity for I2-relative to I1R sites in bovine adrenal medullary cells. Uses: Moxonidine hydrochloride is used as antihypertensive agent. it has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3h]-clonidine to vlm (ventrolateral medulla) membranes in a dose-dependent manner with the ic50 value of 53 ± 10nm. Synonyms: BDF5895 hydrochloride; BDF 5895 hydrochloride; BDF-5895 hydrochloride; 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride. Grades: 98%. CAS No. 75536-04-8. Molecular formula: C9H13Cl2N5O. Mole weight: 278.14. | |
| MPC-0767 | MPC-0767 is a novel L-alanine ester pro-drug of MPC-3100, designed to have improved aqueous solubility compared to MPC-3100. Synonyms: MPC-0767; MPC 0767; MPC0767. Grades: >98%. CAS No. 1310540-32-9. Molecular formula: C26H36BrN7O9S2. Mole weight: 733.64. | |
| MPC-3100 | MPC-3100 targets the N-terminal ATP-binding site of Hsp90 and blocks the activity of ATPase. In the Her2-luciferase degradation assay, MPC-3100 reduces this client protein of Hsp90 with IC50 value of 60nM. In HCT-116 cell lines, MPC-3100 inhibits cell proliferation with IC50 value of 540 nM. Besides that, MPC-3100 shows a broad spectrum anti-proliferative activity against various cancer cell lines, such as NCI-N87 and DU-145. MPC-3100 also inhibits tumor growth in the NCI-N87 gastric cancer xenograft mode. Moreover, PK studies show that MPC-3100 displays a superior oral PK profile, good overall exposure and a reasonable hepatic clearance rate. Phase I clinical studies demonstrate MPC-3100 is safe and tolerated when administered at doses below 600 mg per day. Synonyms: MPC-3100; MPC 3100; MPC3100. Grades: >98%. CAS No. 958025-66-6. Molecular formula: C22H25BrN6O4S. Mole weight: 549.40. | |
| MPC 6827 hydrochloride | MPC 6827 hydrochloride, the hydrochloride salt form of verubulin, inhibits of microtubule formation (IC50 = 1.5 - 3.4 nM). in vitro: inhibits polymerization of tubulin in vivo: inhibits tumor growth. Synonyms: N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine; hydrochloride; MPC-6827; MPC6827; N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine; verubulin; verubulin hydrochloride; Azixa; MPC-6827; UNII-33380QZ0QW; 917369-31-4. CAS No. 917369-31-4. Molecular formula: C17H17N3O.HCl. Mole weight: 315.8. | |
| MPDC | MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter and may be useful in the treatment of neurodegeneration. Synonyms: L-anti-endo-3,4-Methanopyrrolidinedicarboxylic acid. CAS No. 159262-32-5. Molecular formula: C7H9NO4. Mole weight: 171.15. | |
| MPDL3280A | A human, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Synonyms: Atezolizumab; RG 7446; RO 5541267; RG7446; RO5541267; RG-7446; RO-5541267; TECENTRIQ. CAS No. 1380723-44-3. Molecular formula: C37H62N4O2S. Mole weight: 627. | |
| MPEP | MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibiting no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. Grades: >98%. CAS No. 96206-92-7. Molecular formula: C14H11N. Mole weight: 193.24. | |
| MPEP Hydrochloride | Potent and selective antagonist for metabotropic glutamate receptor subtype 5 (mGluR5); Systemically active in vivo. Synonyms: 2-Methyl-6-(phenylethynyl)pyridine Hydrochloride. Grades: >98%. CAS No. 219911-35-0. Molecular formula: C14H12ClN. Mole weight: 229.7. | |
| MPI-0479605 | MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics. Synonyms: MPI-0479605; MPI 0479605; MPI0479605. Grades: 0.98. CAS No. 1246529-32-7. Molecular formula: C22H29N7O. Mole weight: 407.522. | |
| MPI-5a | MPI-5a is a cell-permeable and potent histone deacetylase 6 (HDAC6) inhibitor. It is a cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, leading to inhibition of cancer development, proliferation and invasion. Synonyms: N-hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide. Grades: ≥95%. CAS No. 1259296-46-2. Molecular formula: C16H17N3O3. Mole weight: 299.3. | |
| MPP dihydrochloride | MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors, with > 200-fold selectivity for ERα over Erβ (Ki= 2.7 and 1800 nM at ERα and ERβ receptors respectively). It cannot block EE2 induced luciferase activity with any isoform of zebrafish estrogen receptor. Synonyms: 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride. Grades: ≥98% by HPLC. CAS No. 911295-24-4. Molecular formula: C29H31N3O3.2HCl. Mole weight: 542.5. | |
| MR 16728 hydrochloride | MR 16728 hydrochloride, an analog of cetiedil, enhanced acetylcholine (ACh) release (up to 145% of control) from Torpedo synaptosomes when the release was triggered by a Ca2+ ionophore, A23187 or ionomycin, in the presence of 4 mM Ca2+ in the release medium, but inhibited ACh release induced by KCl depolarization of the presynaptic membrane. Synonyms: Benzeneacetamide, α-cyclohexyl-N-[3-(hexahydro-1H-azepin-1-yl)propyl]-, hydrochloride (1:1); Benzeneacetamide, α-cyclohexyl-N-[3-(hexahydro-1H-azepin-1-yl)propyl]-, monohydrochloride; NSC 662128; α-Cyclohexyl-N-[3-(hexahydro-1H-azepin-1-yl)propyl]benzeneacetamide monohydrochloride; MR-16728 hydrochloride; MR16728 hydrochloride; N-(3-(Azepan-1-yl)propyl)-2-cyclohexyl-2-phenylacetamide monohydrochloride. Grades: ≥95%. CAS No. 207403-36-9. Molecular formula: C23H36N2O.HCl. Mole weight: 393.01. | |
| MRE 3008F20 | MRE 3008F20 is a potent adenosine A3 receptor competitive antagonist, which is selective for human A3 receptors over human A1 and A2A receptors (Ki= 0.29, 141 and 1197 nM respectively). MRE 3008F20 has also been studied extensively in recent advances in adenosine receptor ligand in pulmonary diseases. Synonyms: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea; MRE 3008-F20; MRE 3008F20; MRE 3008 F20; MRE-3008-F20; MRE3008F20; MRE3008F20; MCP-NECA; MCP NECA; MCPNECA. Grades: ≥98% by HPLC. CAS No. 252979-43-4. Molecular formula: C21H20N8O3. Mole weight: 432.44. | |
| MRK 016 | MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator with EC50 value of 3 nM. It has nootropic properties. MRK-016 can produce rapid, ketamine-like antidepressant effects in animal models of depression. Uses: Antidepressant effect. Synonyms: MRK-016; MRK016; 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-pyrazolo[1,5-d][1,2,4]triazine; 3-(9-(tert-Butyl)-8-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)pyrazolo[1,5-d][1,2,4]triazin-2-yl)-5-methylisoxazole; 3-t-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1h-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine; 7-(5-Methyl-1,2-oxazol-3-yl)-3-(2-methyl-2-propanyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine. Grades: >98%. CAS No. 783331-24-8. Molecular formula: C17H20N8O2. Mole weight: 368.40. | |
| MRK 560 | MRK 560, under the IUPAC name N-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide, is a novel orally bioavailable γ-secretase inhibitor and inhibites the production of Aβ40 and Aβ42 (in vitro: IC50 = 0.65 nM). in vivo: Reduces Aβ in the brain (ED50 = 6 mg/kg) and cerebrospinal fluid (CSF) (ED50 = 10 mg/kg) in the rat markedly. Synonyms: N-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide; MRK560; MRK 560; MRK-560; 677772-84-8. CAS No. 677772-84-8. Molecular formula: C19H17ClF5NO4S2. Mole weight: 517.92. | |
| MRS 1220 | MRS 1220, a derivative of the triazoloquinazoline, is a potent and highly selective antagonist at the human A3 adenosine receptor (Ki= 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively.) It exhibits an IC50 value > 1 μM for inhibition of binding to rat A3 receptors. Synonyms: N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide; MRS1220; MRS-1220; MRS 1220. Grades: ≥98% by HPLC. CAS No. 183721-15-5. Molecular formula: C21H14ClN5O2. Mole weight: 403.83. | |
| MRS 1334 | MRS 1334 is a potent and highly specific antagonist for the human adenosine A3 receptor (Ki= are 2.69 nM at hA3). Synonyms: MRS 1334; MRS1334; MRS-1334; 1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester. Grades: ≥98% by HPLC. CAS No. 192053-05-7. Molecular formula: C31H26N2O6. Mole weight: 522.56. | |
| MRS 1477 | MRS 1477, a dihydropyridine derivative, is a TRPV1 positive allosteric modulator, and potentiates vanilloid and proton activation of TRPV1 channels. Synonyms: MRS-1477; MRS 1477; MRS1477; 4-Ethyl-1,4-dihydro-5-[[(2-methoxyethyl)thio]carbonyl]-6-methyl-2-phenyl-3-pyridinecarboxylic acid ethyl ester. Grades: ≥98% by HPLC. CAS No. 212200-21-0. Molecular formula: C21H27NO4S. Mole weight: 389.51. | |
| MRS 1845 | MRS 1845 is a potent SOCE inhibitor that can block Ca2+ capacitative entry resulting in an antiinflammatory effect. MRS 1845 inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). Synonyms: MRS 1845; MRS1845; MRS-1845; N-PROPARGYLNITRENDIPENE; MRS 1845; 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-1-(2-PROPYNYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL, METHYL ESTER; 1, 4-Dihydro-2, 6-di methyl -4- (3-nitrophenyl) -1- (2-propynyl) -3, 5-pyridinedicarboxylicacidethyl methyl ester. Grades: ≥98% by HPLC. CAS No. 544478-19-5. Molecular formula: C21H22N2O6. Mole weight: 398.41. | |
| MRS 2159 | DBO-83 is an agonist of nicotinic acetylcholine receptors (nAChRs), which has anti-injury and anti-forgetting effects. DBO-83 dose-dependently increased the incubation period of paw licking in hot plate mice and decreased the number of abdominal coarctation in acetic acid mice, which was reduced by the nAChR antagonist mecamylamine. Grades: ≥98%. CAS No. 195211-53-1. Molecular formula: C15H11N3O8PNa3. Mole weight: 461.21. | |
| MRS2179 ammonium salt | MRS2179 is a competitive P2Y1 receptor antagonist that inhibits platelet aggregation. Grades: ≥98%. CAS No. 228264-19-5. Molecular formula: C11H17N5O9P2·xNH3. Mole weight: 425.23. | |
| MRS 2211 | MRS 2211 is a competitive P2Y13 receptor antagonist (pIC50 = 5.97), with > 20-fold selectivity over P2Y1 and P2Y12 receptors. It is known that MRS 2211 inhibits ADP-induced inositol trisphosphate (IP3) formation. Research suggests that MRS 2211 inhibits phospholipase C (PLC) response to 2-methylthio-ADP in 1321N1 astrocytoma cells. Synonyms: 2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt; MRS2211; MRS-2211. Grades: ≥96% by HPLC. Molecular formula: C14H10N4O8Na2PCl. Mole weight: 474.66. | |
| MRS 2219 | MRS 2219, a cyclic pyridoxine-alpha4, 5-monophosphate compound, is a selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC50 = 5.9 μM). Synonyms: 1,5-Dihydro-3-hydroxy-8-methyl[1,3,2]dioxaphosphepino[5,6-c]pyridin-9-ol-3-oxide; MRS 2219; MRS-2219; MRS2219. Grades: ≥99% by HPLC. CAS No. 14141-47-0. Molecular formula: C8H10NO5P. Mole weight: 231.14. | |
| MRS 2279 | MRS 2279 is the first broadly applicable, selective and high affinity competitive antagonist radioligand for a P2Y receptor (Ki = 2.5 nM; IC50 = 51.6 nM). Synonyms: MRS2279; MRS-2279; MRS 2279. (1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester diammonium salt. Grades: ≥98% by HPLC. CAS No. 367909-40-8. Molecular formula: C13H18ClN5O8P2.2NH3. Mole weight: 503.78. | |
| MRS 2365 | MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM), with no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Synonyms: [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt; MRS2365; MRS 2365; MRS-2365. Grades: ≥98% by HPLC. CAS No. 436847-09-5. Molecular formula: C13H16N5O9P2SNa3. Mole weight: 549.28. | |
| MRS 2500 tetraammonium salt | MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). It inhibits ADP-induced aggregation of human platelets. Synonyms: (1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt; Bicyclo[3.1.0]hexane-1-methanol, 4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)-, dihydrogen phosphate (ester), tetraammonium salt, (1R,2S,4S,5S)-; MRS-2500 tetraammonium; (1R, 2S, 4S, 5S)-4-(2-iodo-6-(methylamino)-9H-purin-9-yl)-1-((phosphonooxy)methyl)bicyclo[3. 1. 0]hexan-2-yl dihydrogen phosphate, tetraammonia salt. Grades: ≥96% by HPLC. CAS No. 630103-23-0. Molecular formula: C13H18N5O8P2I.4NH3. Mole weight: 629.29. | |
| MRS 2578 | MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. Synonyms: MRS-2578; MRS2578; MRS 2578. Grades: >98%. CAS No. 711019-86-2. Molecular formula: C20H20N6S4. Mole weight: 472.67. | |
| MRS 2690 | MRS 2690 is a potent P2Y14 receptor agonist (EC50 = 49 nM), with 7-fold higher potency than UDP-glucose. Synonyms: Diphosphoric acid 1-α-D-glucopyranosyl ester 2-[(4'-methylthio)uridin-5''-yl] ester disodium salt; MRS2690; MRS-2690; MRS 2690. Grades: ≥98% by HPLC. CAS No. 15039-58-4. Molecular formula: C15H22N2Na2O16P2S. Mole weight: 626.33. | |
| MRS 2768 tetrasodium salt | MRS 2768 tetrasodium salt is a selective P2Y2 agonist (EC50 = 1.89 μM), with no affinity for human P2Y4 or P2Y6 receptors. Synonyms: Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt; MRS 2768 tetrasodium salt; MRS2768 tetrasodium salt; MRS-2768 tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 1047980-83-5. Molecular formula: C15H16N2O18P4Na4. Mole weight: 728.14. | |
| MRS 2905 | MRS 2905 is a potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM), with >2000-fold selectivity over P2Y6. Synonyms: MRS 2905; MRS-2905; MRS2905; 2-Thiouridine-5'-O-(α, β-methylene)diphosphate trisodium salt. Grades: ≥98% by HPLC. Molecular formula: C10H13N2Na3O10P2S. Mole weight: 484.2. | |
| MRS 2957 triethylammonium salt | MRS 2957 triethylammonium salt 7 is a selective P2Y6 receptor agonists (EC50 = 12 nM) for the treatment of muscle wasting and neurodegeneration. It exhibits 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively. Synonyms: MRS 2957 triethylammonium salt; MRS2957 triethylammonium salt; MRS-2957 triethylammonium salt; P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt. Grades: ≥99% by HPLC. CAS No. 1228271-30-4. Molecular formula: C19H28N5O20P3.3(C2H5)3N. Mole weight: 1042.94. | |
| MRS 3777 hemioxalate | MRS 3777 hemioxalate is a high affinity adenosine A3 receptor antagonist (Ki = 47 nM), with > 200-fold selectivity versus A1, A2A and A2B receptors. It may be used in the modulation of blood platelet aggregation. Synonyms: MRS 3777 hemioxalate; MRS3777 hemioxalate; MRS-3777 hemioxalate; 2-Phenoxy-6-(cyclohexylamino)purine hemioxalate. Grades: ≥98% by HPLC. CAS No. 1186195-57-2. Molecular formula: C17H19N5O.½C2H2O4. Mole weight: 354.39. | |
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