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| Product | Description | |
|---|---|---|
| LY 302148 | LY 302148 is a 5-HT1F receptor agonist with potential for migraine therapeutics. Synonyms: 5-fluoro-3-[1-[2-(1-methylpyrazol-4-yl)ethyl]piperidin-4-yl]-1H-indole; 5-fluoro-3-(1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-4-piperidinyl)-1H-indole; LY 302148; LY 302148, monohydrochloride; LY-302148. Grades: >98%. CAS No. 182564-47-2. Molecular formula: C19H23FN4. Mole weight: 326.42. |  |
| LY-3023414 | LY3023414, a quinoline derivative, has been found to be a PI3Kα and mTOR inhibitor that could influence cell proliferation and cycle of tumor cells. It was just planed a Phase II trial for Pancreatic cancer by Eli Lilly. Uses: Ly3023414 has been found to be a pi3kα and mtor inhibitor that could influence cell proliferation and cycle of tumor cells. Synonyms: LY3023414; UNII-C88817F47Y; LY-3023414; C88817F47Y; GTPL8918; 8-[5-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one. Grades: 98%. CAS No. 1386874-06-1. Molecular formula: C23H25N4O3. Mole weight: 406.48. | |
| LY 303511 | LY 303511 is an inactive analogue of the phosphoinositide 3-kinase inhibitor LY294002, but it does not inhibit PI3K. It enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells, and reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM in MIN6 insulinoma cells. Synonyms: EM 101; 8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one; 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-; 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one; NSC736787. Grades: >98%. CAS No. 154447-38-8. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
| LY303511 hydrochloride | Cas No. 854127-90-5. | |
| LY-306669 | LY-306669, a tetrazol derivative, has been found to be a leukotriene B4 receptor antagonist that was once studied its effect in acute lung injury. Synonyms: LY306669; LY 306669; 5-Ethyl-3'-fluoro-4-((6-methyl-6-(1H-tetrazol-5-yl)heptyl)oxy)-(1,1'-bipenyl)-2-ol monosodium salt; LY-306669; DTXSID70165296; HE116606. Grades: 98%. CAS No. 153227-04-4. Molecular formula: C23H28FN4NaO2. Mole weight: 434.49. | |
| LY310762 | LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. Synonyms: LY310762; LY 310762; LY-310762; LY310762 HCl. Grades: >98%. CAS No. 192927-92-7. Molecular formula: C24H27FN2O2.HCl. Mole weight: 430.94. | |
| LY311727 | LY311727 is an inhibitor of Group IIA sPLA2 (IC50 = 0.47 μM). LY311727 inhibited sPLA2-induced platelet aggregation. Synonyms: LY-311727; LY 311727; 3-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxypropylphosphonic acid. Grades: ≥95%. CAS No. 164083-84-5. Molecular formula: C22H27N2O5P. Mole weight: 430.4. | |
| LY3130481 | LY3130481, a benzothiazol derivative, has been found to be the first AMPA receptor antagonist that could be probably effective in studies of epilepsy. It has just been planed a Phase I trial by Cerecor. Synonyms: LY3130481; LY-3130481; LY 3130481; CERC-611; CERC611; CERC 611. (S)-6-(1-(1-(5-(2-hydroxyethoxy)pyridin-2-yl)-1H-pyrazol-3-yl)ethyl)benzo[d]thiazol-2(3H)-one. Grades: 98%. CAS No. 1610802-47-5. Molecular formula: C19H18N4O3S. Mole weight: 382.44. | |
| LY 320135 | LY 320135 is a selective CB1 receptor antagonist. Uses: Cannabinoid receptor antagonists. Synonyms: LY320135; LY 320135; LY-320135. 4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile. Grades: ≥98% by HPLC. CAS No. 176977-56-3. Molecular formula: C24H17NO4. Mole weight: 383.4. | |
| LY3214996 | LY3214996 is a highly selective and orally available inhibitor of ERK1 an dERK2 (IC50= 5 nM for both enzymes in biochemical assays)and thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. Synonyms: temuterkib; LY-3214996; LY 3214996. CAS No. 1951483-29-6. Molecular formula: C22H27N7O2S. Mole weight: 453.56. | |
| LY-326325 | LY-326325, a decahydroisoquinaline derivative, has been found to be an AMPA receptor antagonist and was once studied for neuroprotection. Synonyms: LY 326325; LY326325; LY326325; (-)-(3S,4aR,6R,8R)-6-(2-(1(2)H-Tetrazol-5-yl)ethyl)dec ahydroisoquinaline-3-carboxylic acid; (4aalpha,8aalpha)-6beta-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3beta-carboxylic acid. Grades: 98%. CAS No. 177314-99-7. Molecular formula: C13H21N5O2. Mole weight: 279.34. | |
| LY 333531 mesylate | LY 333531 mesylate is an orally-available protein kinase C β (PKC-β) specific inhibitor used for the treatment of diabetic nephropathy and diabetic macular edema. Uses: The treatment of diabetic nephropathy and diabetic macular edema. Synonyms: LY 333531 mesylate; LY333531 mesylate; LY-333531 mesylate; Ruboxistaurin mesylate; (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione mesylate. Grades: 99%. CAS No. 192050-59-2. Molecular formula: C28H28N4O3.CH4O3S. Mole weight: 564.65. | |
| LY 334370 hydrochloride | LY 334370 hydrochloride is a 5-HT1F receptor agonist. It shows antimigraine effects. Synonyms: Benzamide, 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-, hydrochloride (1:1); Benzamide, 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-, monohydrochloride; LY-334370 hydrochloride; LY334370 hydrochloride. Grades: ≥99% by HPLC. CAS No. 199673-74-0. Molecular formula: C21H22FN3O.HCl. Mole weight: 387.88. | |
| LY341495 | Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo. Synonyms: LY 341495; LY-341495. Grades: >98%. CAS No. 201943-63-7. Molecular formula: C20H19NO5. Mole weight: 353.37. | |
| LY 341495 disodium salt | Disodium salt of LY 341495. LY 341495 is a group II metabotropic glutamate receptor antagonist. Synonyms: LY 341495 disodium salt; LY341495 disodium salt; LY-341495 disodium salt; (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt. Grades: ≥97% by HPLC. Molecular formula: C20H17NNa2O5. Mole weight: 397.33. | |
| LY 344864 | LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for SR-1F, SR-1A, SR-1B. Synonyms: N-[(6R)-6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]-4-fluorobenzamide;hydrochlorideLY-344864; LY344864; LY 344864; LY-344864 HCl; LY-344864 hydrochloride. Grades: >99 %. CAS No. 186544-26-3. Molecular formula: C21H22FN3O. Mole weight: 351.42. | |
| LY 344864 hydrochloride | LY 344864 hydrochloride is a 5-HT1F receptor agonist with EC50 value of 3 nM. Synonyms: LY 344864 hydrochloride; LY344864 hydrochloride; LY-344864 hydrochloride; N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217756-94-9. Molecular formula: C21H22N3OF.HCl. Mole weight: 387.88. | |
| LY 344864 racemate | LY 344864 racemate is a 5-HT1F receptor agonist. Synonyms: LY 344864 racemate; LY344864 racemate; LY-344864 racemate. CAS No. 186543-64-6. Molecular formula: C21H22FN3O. Mole weight: 351.42. | |
| LY 354740 | LY 354740 is a selective group II mGlu receptors agonist with EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors. It shows antianxiety and antiaddictive activity. Synonyms: Eglumetad; LY-354740; LY354740; LY 354740; (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 176199-48-7. Molecular formula: C8H11NO4. Mole weight: 185.18. | |
| (±)-LY 367385 | (±)-LY367385 is a selective mGlu1a antagonist. Synonyms: 4-[Amino(carboxy)methyl]-3-methylbenzoic acid; LY 367385; LY-367385; LY367385. Grades: 98%. CAS No. 198419-90-8. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
| LY 367385 | LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is used to treat inflammatory diseases and neurodegenerative diseases. Synonyms: LY367385; LY 367385; LY-367385; (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid; 4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid. Grades: ≥99% by HPLC. CAS No. 198419-91-9. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
| LY 379268 | LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY379268 can attenuate cocaine-induced increases in DA in nonhuman primates. Synonyms: LY379268; LY 379268; LY-379268; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid. Grades: ≥99% by HPLC. CAS No. 191471-52-0. Molecular formula: C7H9NO5. Mole weight: 187.15. | |
| LY 379268 disodium salt | Sodium salt of LY 379268. LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY379268 can attenuate cocaine-induced increases in DA in nonhuman primates. Synonyms: LY 379268 disodium salt; LY379268 disodium salt; LY-379268 disodium salt; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt. Grades: ≥98% by HPLC. Molecular formula: C7H7NNa2O5. Mole weight: 231.11. | |
| LY 393558 | LY 393558 is a 5-HT reuptake inhibitor with pIC50 value of 8.48. It is also a dual 5-HT1B/1D receptor antagonist with pKB values of 9.05 and 8.98 respectively. Synonyms: LY 393558; LY-393558; LY393558; 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide. Grades: ≥97% by HPLC. CAS No. 271780-64-4. Molecular formula: C26H31FN4O4S2. Mole weight: 546.68. | |
| (±)-LY 395756 | (±)-LY 395756 is a mixed mGlu2 agonist/mGlu3 antagonist. Synonyms: LY 395756; LY395756; LY-395756; (1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 852679-66-4. Molecular formula: C9H13NO4. Mole weight: 199.21. | |
| LY 404187 | LY 404187 is an allosteric modulator of AMPA receptors (IC50 = 0.15μM, 0.21μM, 1.66μM and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i, respectively). Synonyms: LY-404187; LY 404187; LY404187. N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide. Grades: ≥98% by HPLC. CAS No. 211311-95-4. Molecular formula: C19H22N2O2S. Mole weight: 342.46. | |
| LY-411575 isomer 1 | LY-411575 isomer 1, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50 = 0.078 nM/0.082 nM in membrane-assay/in cell-based γ-secretase assays) and also inhibits Notch clevage (IC50 = 0.41 nM). Synonyms: LY 411575 isomer 1; LY411575 isomer 1; (2S)-2-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; LY-411575 (isomer 1); HY-50752A; ZINC38382410; CS-3132; 209984-58-7. CAS No. 209984-58-7. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| LY-411575 isomer 2 | LY-411575 isomer 2 is an isomer of LY411575, which is a potent and cell-permeable γ-secretase inhibitor with IC50s of 0.078 and 0.082 nM in membrane-assay and cell-based γ-secretase assays, respectively. LY411575 also inhibits Notch clevage with an IC50 of 0.41 nM. Synonyms: N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-D-alaninamide; Benzeneacetamide, N-[(1R)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-; LY411575 isomer 2; LY 411575 isomer 2. Grades: ≥98%. CAS No. 2070009-70-8. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| LY-411575 isomer 3 | LY-411575 isomer 3 is an isomer of LY411575, which is a potent and cell-permeable γ-secretase inhibitor with IC50s of 0.078 and 0.082 nM in membrane-assay and cell-based γ-secretase assays, respectively. LY411575 also inhibits Notch clevage with an IC50 of 0.41 nM. Synonyms: N2-[(2R)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-D-alaninamide; Benzeneacetamide, N-[(1R)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αR)-; LY411575 isomer 3; LY 411575 isomer 3. Grades: ≥98%. CAS No. 2070009-28-6. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| (±)-LY 426965 dihydrochloride | (±)-LY 426965 dihydrochloride is a selective 5-HT1A antagonist. Synonyms: (±)-LY 426965 dihydrochloride; (±)-LY426965 dihydrochloride; (±)-LY-426965 dihydrochloride; 1-Cyclohexyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]-2-methyl-2-phenyl-1-butanone dihydrochloride. Grades: 99%. CAS No. 228418-81-3. Molecular formula: C28H38N2O2.2HCl. Mole weight: 507.54. | |
| LY 426965 dihydrochloride | LY 426965 dihydrochloride is a potent and selective 5-HT1A antagonist that is more active than its opposite enantiomer (R)-(-)-LY 426965. Synonyms: LY 426965 dihydrochloride; LY426965 dihydrochloride; LY-426965 dihydrochloride; (2S)-1-cyclohexyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methyl-2-phenylbutan-1-one dihydrochloride. Grades: 98%. Molecular formula: C28H38N2O2.2HCl. Mole weight: 507.54. | |
| LY450108 | AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian central nervous system (CNS). Recent evidence has shown that in addition to modulating fast synaptic plasticity and memory processes, AMPA receptor potentiators alter downstream signalling pathways and may thereby have utility in other CNS disorders. Synonyms: LY 450108; LY-450108. Grades: >98%. CAS No. 376594-67-1. Molecular formula: C19H22F2N2O3S. Mole weight: 396.45. | |
| LY 450139 | Semagacestat is a gamma-secretase inhibitor originally developed by Eli Lilly. In Aug 2010, Phase-III for Alzheimer's disease was discontinued. Uses: Alzheimer's disease. Synonyms: LY 450139; LY450139; LY-450139. (S)-2-hydroxy-3-methyl-N-((S)-1-(((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)amino)-1-oxopropan-2-yl)butanamide. Grades: 98%. CAS No. 866488-53-1. Molecular formula: C19-H27-N3-O4. Mole weight: 361.44. | |
| LY451395 | Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species. LY404187 and LY451395 reverses the central effects of an acutely intoxicating dose of ethanol in the rat. LY451395 significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward. Synonyms: Mibampator; LY 451395; LY-451395. Grades: >98%. CAS No. 375345-95-2. Molecular formula: C21H30N2O4S2. Mole weight: 438.6. | |
| LY 456236 hydrochloride | Cas No. 338736-46-2. | |
| LY 487379 hydrochloride | LY-487379 is an allosteric modulator for the metabotropic glutamate receptor group II subtype. It has anti-hyperthermic effects. Synonyms: LY 487379 hydrochloride; LY-487379 hydrochloride; LY487379 hydrochloride; 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 353229-59-1. Molecular formula: C21H19F3N2O4S.HCl. Mole weight: 488.91. | |
| LY-518674 | LY518674, a phenoxypropionic acid derivative, is a Potent and selective PPAR-alpha agonist produced a dose-dependent increase in serum HDL-c, resulting in 208 +/- 15% elevation at optimum dose. Uses: Peroxisome proliferator-activated receptor alpha agonists. Synonyms: LY518674; LY-518674; LY 518674. 2-(4-(3-(2,5-dihydro-1-((4-methylphenyl)methyl)-5-oxo-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methyl-Propanoic acid. Grades: ≥95%. CAS No. 425671-29-0. Molecular formula: C23H27N3O4. Mole weight: 409.48. | |
| LY-53857 | LY-53857 is a selective and potent 5-HT2 serotonin receptor antagonist. It was developed by Eli Lilly and Company. Synonyms: LY 53857; LY-53857; LY53857. 6-Methyl-1-(1-methylethyl)ergoline-8β-carboxylic acid 2-hydroxy-1-methylpropyl ester maleate salt;LY53857;Ergoline-8-carboxylic acid, 6-methyl-1-(1-methylethyl)-, 2-hydroxy-1-methylpropyl ester, (8beta)-, (Z)-2-butenedioate (1:1) (salt). Grades: 98%. CAS No. 60634-51-7. Molecular formula: C23H32N2O3. Mole weight: 500.58. | |
| LYC-55716 | LYC-55716 is a first-in-class oral, small-molecule agonist of nuclear receptor retinoic acid-related orphan receptor γ (RORγ). Synonyms: LYC-55716; LYC 55716; LYC55716; Cintirorgon; 3-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid; SCHEMBL18302870. CAS No. 2055536-64-4. Molecular formula: C27H23F6NO6S. Mole weight: 603.53. | |
| Lyn-IN-1 | Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor, but it does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. It can block the autophosphorylation of Bcr-Abl and suppresses the growth of Bcr-Abl-positive leukemic cell lines including K562, KU812 and BaF3/wt. It is also highly potent to inhibit tumor growth in murine tumor models. Synonyms: INNO-406; NS-187; INNO 406; NS 187; INNO406; NS187. Grades: >98%. CAS No. 887650-05-7. Molecular formula: C30H31F3N8O. Mole weight: 576.62. | |
| [Lys5,?MeLeu9,?Nle10]?-?Neurokinin A (4-10) Fragment | [Lys5,MeLeu9,Nle10]-Neurokinin A (4-10) Fragment is a neurokinin A derivative. It is an NK2 agonist with IC50 value of 6.1 nM. It can induce contraction in smooth muscle cells of rodents. Synonyms: (3S,6S,9S,12S,18S,21S)-3-Amino-6-(4-aminobutyl)-9-benzyl-21-carbamoyl-18-isobutyl-12-isopropyl-17-methyl-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosan-1-oic acid. Grades: ≥95% by HPLC. CAS No. 137565-28-7. Molecular formula: C39H65N9O9. Mole weight: 804. | |
| Lys-CoA | | |
| Lys-γ3-MSH | Lys-γ3-MSH, a melanocortin peptide derived from the C-terminal of the 16?kDa fragment of POMC, potentiates the steriodogenic action of corticotrophin on the adrenal cortex, possibly via the MC3 receptor. CAS No. 156159-18-1. Molecular formula: C128H193N45O39S. Mole weight: 3018.27. | |
| M 084 hydrochloride | M 084 hydrochloride is a TRPC4/5 channel blocker with IC50 values of 3.7-10.3 and 8.2 μM, respectively. It weakly blocks TRPC3 channels. It has rapid anxiolytic and antidepressant effects in vivo. It is a useful intermediate. Synonyms: M 084 hydrochloride; M084 hydrochloride; M-084 hydrochloride; N-Butyl-1H-benzimidazol-2-amine hydrochloride. Grades: ≥99% by HPLC. Molecular formula: C11H16N3Cl. Mole weight: 225.72. | |
| M 24 | M 24 is the first selective AT2 receptor agonist (Ki 0.4nM and 10.000 nM for AT2 and AT1 respectively). M 24 effects against endothelial inflammation and leukocyte adhesion both in vitro and in vivo. Synonyms: M 24; M24; M-24; butyl N-[3-[4-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate. Grades: 98%. CAS No. 477775-14-7. Molecular formula: C23H29N3O4S2. Mole weight: 475.62. | |
| M 25 | M 25 is a potent Smoothened (Smo) receptor antagonist with IC50 value of 5 nM. It inhibits the Hedgehog signaling pathway. It also inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells. It antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line. Synonyms: M 25; M25; M-25; N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide. Grades: ≥98% by HPLC. Molecular formula: C23H29N3O2. Mole weight: 379.50. | |
| M2 ion channel blocker | M2 ion channel blocker is an antiviral agent that works through blocking the activity of M2 ion channel. Uses: M2 ion channel blocker is an antiviral agent that works through blocking the activity of m2 ion channel. Synonyms: methyl(2S)-2-(1-adamantylmethylamino)-3-(1H-imidazol-5-yl)propanoate; 1190215-03-2; CHEMBL2324198; SCHEMBL15029083; 3801AH; W-6012; W 6012; W6012. Grades: 95%. CAS No. 1190215-03-2. Molecular formula: C18H27N3O2. Mole weight: 317.43. | |
| M344 | M344 is a potent HDAC inhibitor, which can also induce expression of the pro-apoptotic genes, Puma and Bax, together with the morphological features of apoptosis, in MCF-7 cells. Synonyms: M 344; M-344; Histone Deacetylase Inhibitor III. Grades: >98%. CAS No. 251456-60-7. Molecular formula: C16H25N3O3. Mole weight: 307.39. | |
| m-3M3FBS | m-3M3FBS is a direct activator of phospholipase C (PLC) that stimulates the increase in cytoplasmic calcium, inositol phosphate formation and superoxide generation in a variety of cell types. It is used in biological studies on Ca2+ homeostasis independently of phospholipase C activation. It is also used to study PLC signaling in cells and animals, often in conjunction with the PLC inhibitor U-73122. It has also been used for intracellular calcium analysis and MAP kinase assay in 293T cells. It also inhibits growth of the leukemic cell lines U937 and THP-1. Synonyms: m-3M3FBS; m 3M3FBS; m3M3FBS; 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide; N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 200933-14-8. Molecular formula: C16H16F3NO2S. Mole weight: 343.36. | |
| M3 receptor antagonist 1 | An antagonist of muscarinic M3-receptor. Synonyms: CHF5407; CHF-5407; CHF 5407; 1-Azoniabicyclo[2.2.2]octane, 3-[[[ (3-fluorophenyl) [ (3, 4, 5-trifluorophenyl) methyl]amino]carbonyl]oxy]-1-[2-oxo-2- (2-thienyl) ethyl]-, bromide,(3R)-. CAS No. 1004312-94-0. Molecular formula: C27H25BrF4N2O3S. Mole weight: 613.46. | |
| M40 | M40 is a potent, non-selective antagonist of galanin receptor, and has no effect on chow or fat intake. Synonyms: M 40; M-40; H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2; L-Alaninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-; Glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-alaninamide; M 40 (peptide). Grades: ≥95%. CAS No. 143896-17-7. Molecular formula: C95H146N22O24. Mole weight: 1980.31. | |
| M50054 | M50054 is a cell-permeable inhibitor of apoptosis induction, blocking the caspase-3 activation. It was shown to suppress apoptosis induced by various stimuli via inhibiting caspase-3. Synonyms: Apoptosis Inhibitor; 2,2'-Methylenebis(cyclohexane-1,3-dione); 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione; 2,2'-methylenedicyclohexane-1,3-dione; 2-[(2,6-Dioxocyclohexyl)methyl]cyclohexane-1,3-dione. Grades: ≥98%. CAS No. 54135-60-3. Molecular formula: C13H16O4. Mole weight: 236.3. | |
| M62812 | M62812 is a toll-like receptor 4 (TLR4) transduction inhibitor. It inhibits LPS-induced NF-κB activation in HEK293 cells with IC50 value of 2.4 μg/mL). It also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. It could prolong survival in a mouse septic shock model. It suppresses endothelial cell and leukocyte activation, preventing lethal septic shock in mice. Synonyms: 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride; 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine Hydrochloride (1:2). Grades: ≥98% by HPLC. CAS No. 613263-00-6. Molecular formula: C13H13N3OSCl2. Mole weight: 330.23. | |
| M8 B hydrochloride | M8 B hydrochloride is a selective and potent channel blocker of transient receptor potential melastatin 8 (TRPM8). It blocks cold-induced and icilin or methol-induced activation of rat, human, and murine TRPM8 channels. It displays no effect at other TRP channels with IC50 value of > 20 mM. It decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice. It may be used to induce therapeutic hypothermia, which is an effective treatment in cardiac arrest. Synonyms: N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride; N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride; N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride. Grades: ≥99% by HPLC. CAS No. 883976-12-3. Molecular formula: C22H25N2O3SCl. Mole weight: 432.96. | |
| MA 2029 | MA 2029 is a novel, potent, selective and competitive motilin receptor antagonist with IC50 value of 4.9 nM. It inhibits motilin-induced duodenal muscle contractions in animal models and colonic and abdominal contractions in rabbits. It may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility such as IBS. It is selective for the motilin receptor over a range of other receptors and ion channels. It is orally active. Synonyms: MA-2029; MA 2029; MA2029; 4-Fluoro-N-methyl-L-phenylalanyl-N-methyl-L-valyl-3-(1,1-dimethylethyl)-N-ethyl-L-tyrosinamide; (2S)-N-[(2S)-3-(3-tert-butyl-4-hydroxyphenyl)-1-(ethylamino)-1-oxopropan-2-yl]-2-[[(2S)-3-(4-fluorophenyl)-2-(methylamino)propanoyl]-methylamino]-3-methylbutanamide. Grades: ≥98% by HPLC. CAS No. 287206-61-5. Molecular formula: C31H45FN4O4. Mole weight: 556.71. | |
| Mabuterol | Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR) used as an antiasthmatic. Synonyms: 1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol. Grades: ≥98%. CAS No. 56341-08-3. Molecular formula: C13H18ClF3N2O. Mole weight: 310.7. | |
| Mabuterol hydrochloride | Mabuterol hydrochloride is a salt form of Mabuterol, which is a selective β2 adrenoreceptor agonist. Synonyms: 1-(4-Amino-3-chloro-5-trifluoromethylphenyl)-2-tert-butylaminoethanol hydrochloride. CAS No. 54240-36-7. Molecular formula: C13H19Cl2F3N2O. Mole weight: 347.203. | |
| MAC13243 | MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA. Synonyms: MAC13243 HCl; MAC 13243; MAC-13243; MAC13243 hydrochloride. Grades: >98%. CAS No. 1071638-38-4. Molecular formula: C20H25Cl2N3O2S. Mole weight: 442.4. | |
| Macbecin I | Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 by binding to the ATP-binding site (IC50 = 2μM). It exhibits antitumor and cytocidal activities (IC50~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. It exhibits higher affinity and potency than geldanamycin. Grades: >98%. CAS No. 73341-72-7. Molecular formula: C30H42N2O8. Mole weight: 558.67. | |
| mAChR-IN-1 | mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM. Synonyms: mAChR-IN-1; 119391-56-9; 1'-(4-IODOBENZYL)-3-PHENYL-[3,4'-BIPIPERIDINE]-2,6-DIONE; CHEMBL274789; 3-[1-[(4-iodophenyl)methyl]piperidin-4-yl]-3-phenylpiperidine-2,6-dione; SCHEMBL9110529; BCP30855; EX-A3202; BDBM50228211; FD5014; MFCD27992056; AKOS027253854; CS-3430; NCGC00390609-01; HY-12426; 1'-[(4-IODOPHENYL)METHYL]-3-PHENYL-[3,4'-BIPIPERIDINE]-2,6-DIONE. Grades: >98%. CAS No. 119391-56-9. Molecular formula: C23H25IN2O2. Mole weight: 488.36. | |
| Mafenide | Mafenide is a sulfonamide-type medication. Synonyms: Sulfamylon. Grades: >98%. CAS No. 138-39-6. Molecular formula: C7H10N2O2S. Mole weight: 186.23. | |
| Mafenide Acetate | Mafenide is a bacteriostatic antibiotic with a broad activity against Gram positive, Gram negative bacteria and Clostridia. Mafenide acetate penetrates eschar and prevents heavy colonization in burn wounds. Uses: Anti-bacterial agents. Synonyms: Sulfamylon Acetate. Grades: >98%. CAS No. 13009-99-9. Molecular formula: C9H14N2O4S. Mole weight: 246.28. | |
| Mafenide hydrochloride | The hydrochloride salt form of Mafenide, a Sulfanilamide derivative, could be used as an antibiotic. Mafenide could oftn be existed as acetate salt form. Uses: The hydrochloride salt form of mafenide could be used as an antibiotic. mafenide could oftn be existed as acetate salt form. Synonyms: Mafenide hydrochloride; 4-Aminomethylbenzenesulfonamide hydrochloride; Marfanil; 4-(Aminomethyl)benzenesulfonamide hydrochloride. Grades: 98%. CAS No. 138-37-4. Molecular formula: C8H12N2O2S. Mole weight: 222.69. | |
| Malotilate | Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis. Synonyms: Malotilate; CL-1500; NKK 105; NKK-105. Grades: >98%. CAS No. 59937-28-9. Molecular formula: C12H16O4S2. Mole weight: 288.38. | |
| MAP4 | MAP4 is a selective group III metabotropic glutamate receptor (mGluR) antagonist in some electrophysiological systems. It acts as a group II/group III agonist in certain neurochemical systems. It modulates transmission of gustatory inputs in the brain system. It has displayed its potency in the perforant path of rat hippocampal slices. Synonyms: (S)-2-Amino-2-methyl-4-phosphonobutyric acid; α-Methyl-AP4; MAP-4; MAP 4. Grades: ≥96% by HPLC. CAS No. 157381-42-5. Molecular formula: C5H12NO5P. Mole weight: 197.13. | |
| Marimastat | Marimastat is an orally-active synthetic broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Synonyms: BB-2516; BB2516; BB 2516; TA-2516; TA2516; TA 2516; Marimastat; N-[2,2-dimethyl-1- (methylcarbamoyl)propyl]-2- [hydroxy-(hydroxycarbamoyl)methyl]- 4- methyl-pentanamide; (2S,3R)-3-(((1S)-2,2-dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid; (2S,3R)-3-{(S)-[2,2-dimethyl-1-(methylcarbamoyl) propyl]carbamoyl}-2-hydroxy-5-methylhexanohydroxamic acid. CAS No. 154039-60-8. Molecular formula: C15H29N3O5. Mole weight: 331.413. | |
| Marinopyrrole A | Marinopyrrole A, a new Mcl-1 inhibitor, could influence Mcl-1-Bim interaction and induce the degradation of Mcl-1 proteasomal and also lead to the apoptosis of Mcl-1-dependent cancer cells. IC50: 10.1 uM. Uses: Marinopyrrole a is a new mcl-1 inhibitor and could influence mcl-1-bim interaction and induce the degradation of mcl-1 proteasomal and also lead to the apoptosis of mcl-1-dependent cancer cells. Synonyms: Maritoclax; (±)-Marinopyrrole A. Grades: 95%. CAS No. 1227962-62-0. Molecular formula: C22H12Cl4N2O4. Mole weight: 510.15. | |
| Maropitant | Maropitant is a neurokinin (NK1) receptor antagonist. Synonyms: Maropitant; CJ-11972; CJ-11,972; CJ11,972. Cerenia. Grades: >98%. CAS No. 147116-67-4. Molecular formula: C32H40N2O. Mole weight: 468.685. | |
| Mavatrep | Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CYP isoforms 3A4, 1A2, and 2D6. It antagonizes capsaicin-induced Ca2+ influx, with an IC50 value of 4.6 nM in a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels. It blocks the activation of hTRPV1 channels by Capsaicin and pH in a concentration-dependent fashion, with IC50 values of 23 and 6.8 nM respectively. It exhibits superior pharmacodynamic properties in the CFA model of inflammatory pain in vivo. It was selected for clinical development for the treatment of pain. It was developed by Johnson & Johnson and now in clinic phase 1 with no progress. Uses: Mavatrep was selected for clinical development for the treatment of pain. Synonyms: JNJ-39439335; JNJ 39439335; JNJ39439335; 2-[2-[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol. Grades: >98 %. CAS No. 956274-94-5. Molecular formula: C25H21F3N2O. Mole weight: 422.44. | |
| Mavoglurant | Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist (IC50=30 nM), as a selective non-competitive antagonist. Synonyms: AFQ056; AFQ-056; AFQ 056; (3aR,4S,7aR)-Octahydro-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-1H-indole-1-carboxylic acid methyl ester; methyl (3aR,4S,7aR)-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-3,3a,5,6,7,7a-hexahydro-2H-indole-1-carboxylate. Grades: ≥95%. CAS No. 543906-09-8. Molecular formula: C19H23NO3. Mole weight: 313.39. | |
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