BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Levobunolol hydrochloride | Levobunolol hydrochloride, a beta1- and beta2-adregergic blocking agent, has proved to be an effective ocular hypotensive agent to treat glaucoma. Synonyms: 5-[(2R)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride AKBeta Akorn Brand of Levobunolol Hydrochloride Allergan Brand of Levobunolol Hydrochloride Apo Levobunolol Apo-Levobunolol ApoLevobunolol Apotex Brand of Levobuno. Grades: 95%. CAS No. 27912-14-7. Molecular formula: C17H26ClNO3. Mole weight: 327.85. |  |
| Levonantradol hydrochloride | Levonantrado is a synthetic cannabinoid analog of dronabinol developed by Pfizer in the 1980s. Levonantrado is around 30x more potent than THC, and exhibits antiemetic and analgesic effects via activation of CB1 and CB2cannabinoid receptors. Now, Levonantradol is not used in medicine,but it is widely used in research into the potential therapeutic applications of cannabinoids. Uses: Used in research into the potential therapeutic applications of cannabinoids. Synonyms: CP 50,556-1; CP-50,556-1;UNII-V92884KHRI;[(6S,6aR,9R,10aR)-9-hydroxy-6-methyl-3-[(2R)-5-phenylpentan-2-yl]oxy-5,6,6a,7,8,9,10,10a-octahydrophenanthridin-1-yl] acetate;hydrochloride;71048-87-8(base). Grades: 98%. CAS No. 70222-86-5. Molecular formula: C27H36ClNO4. Mole weight: 474.03. | |
| Levonordefrin | Levonordefrin is a adrenergic receptor agonist and can be used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. Levonordefrin is also a metabolite of the antihypertensive drug methyldopa. Uses: Decongestant; vasoconstrictor. Synonyms: 4-[(1R,2S)-2-Amino-1-hydroxypropyl]-1,2-benzenediol; BA 2818; Corbadrine; D-(-)-Cobefrin; L-α-Methylnoradrenaline; Levonordefrin; Neo-cobefrin; l-Cobefrin; (-)-Nordefrin. Grades: 98%. CAS No. 829-74-3. Molecular formula: C9H13NO3. Mole weight: 183.20. | |
| Levophacetoperane hydrochloride | Levophacetoperane hydrochloride, a sympathomimetic central nervous system stimulant used to treat depression, inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake. Synonyms: Levophacetoperane hydrochloride; Levophacetoperan HCl; RP 8228; RP-8228; RP8228; [phenyl(piperidin-2-yl)methyl] acetate;hydrochloride. CAS No. 23257-56-9. Molecular formula: C14H20ClNO2. Mole weight: 269.77. | |
| Levoprotiline hydrochloride | Levoprotiline is a Histamine H1 receptor antagonist originated by Novartis. It is an antidepressant. But clinical trials for Major depressive disorder were discontinued. Uses: Major depressive disorder. Synonyms: Levoprotiline hydrochloride; Levoprotiline HCl; CGP 12103 A; CGP-12 103 A; CGP 12103; CGP 12103A; CGS 12103;(R)-alpha-((methylamino)methyl)-9,10-Ethanoanthracene-9(10H)-ethanol bydrochloride. Grades: 98%. CAS No. 76496-69-0. Molecular formula: C20H24ClNO. Mole weight: 329.87. | |
| Lexacalcitol | KH1060 metabolism could be blocked by the cytochrome P450 inhibitor, ketoconazole. KH1060 was not an effective competitor of C24 oxidation of 1alpha,25-(OH)2D3. Certain hydroxylated metabolites of KH1060 retained significant biological activity in vitamin D-dependent reporter gene systems (chloramphenicol acetyltransferase). KH 1060 inhibited PBMC proliferation and decreased TNF-alpha levels in IBD patients and this effect was synergistic with anti-TNF-alpha. VDR protein levels were significantly increased by PBMC treatment with KH 1060 or anti-TNF-alpha or their combination in ulcerative colitis (UC) patients, and decreased in Crohn's disease (CD) patients, treating the cells with KH 1060. A synergistic inhibition was registered combining KH 1060 and anti-TNF, at well-defined concentrations. 0.1 nM KH 1060 produced a significant decrease in TNF-alpha levels, determined by ELISA, although less remarkable than in the presence of anti-TNF. Uses: Antineoplastic agents. Synonyms: KH 106; KH 1060; KH-1060; KH1060. Grades: >98%. CAS No. 131875-08-6. Molecular formula: C28H46O4. Mole weight: 446.66. | |
| Lexanopadol | Lexanopadol is a potent Opioid mu receptor agonist originated by Grunenthal. Lexanopadol is suited for the management of moderate to severe chronic pain, including neuropathic pain. No recent reports of development were identified for phase-I development in Pain in Germany. Uses: Pain. Synonyms: GRT6006; GRT 6006; GRT-6006; GRT-13106G; GRT 13106G; GRT13106G; Lexanopadol; (1r,4r)-6'-fluoro-N-methyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine;trans-6'-Fluoro-N-methyl-4-phenyl-4',9'-dihydro-3'H-spiro(cyclohexane-1,1'-pyrano(3,4-b)indol)-4-amine;GRT6006. Grades: 98%. CAS No. 1357348-09-4. Molecular formula: C23H25FN2O. Mole weight: 364.46. | |
| Lexibulin | lexibulin, also known as CYT997, is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: CYT997; CYT-997; CYT 997. lexibulin. CAS No. 917111-44-5. Molecular formula: C24H30N6O2. Mole weight: 434.544. | |
| Lexibulin dihydrochloride | Lexibulin dihydrochloride is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. It inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase, which may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Synonyms: CYT-997 dihydrochloride; CYT 997 dihydrochloride; CYT997 dihydrochloride. Grades: >98%. CAS No. 917111-49-0. Molecular formula: C24H32Cl2N6O2. Mole weight: 507.46. | |
| LFM-A13 | LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). LFM-A13 may be useful as a new class of chemosensitizing and apoptosis-promoting antileukemic agents for treatment of patients with chemotherapy-resistant B-lineage leukemias or lymphomas. Synonyms: 2-Butenamide, 2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-; 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; 2-Cyano-3-hydroxy-but-2-enoic acid (2,5-dibromo-phenyl)-amide; LFM-A13/DDE-28; α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide. Grades: ≥95%. CAS No. 62004-35-7. Molecular formula: C11H8Br2N2O2. Mole weight: 360.00. | |
| LG 100268 | LG 100268 is a retinoid X receptor agonist with EC50 value of 4 nM. It can inhibit vinyl carbamate-induced lung tumor growth in mice in vivo. Synonyms: LG100268; LG-100268; 6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 153559-76-3. Molecular formula: C24H29NO2. Mole weight: 363.49. | |
| LG 100754 | LG 100754 is a RXR:PPARγ agonist. It can decrease glucose levels and relieve insulin resistance in mice. LG 100754 shows antidiabetic properties in vivo. Synonyms: CD 3159; CD-3159; CD3159; LG 100754; LG-100754; LG 100754; LGD 100754; LGD-100754; LGD100754; (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid. Grades: ≥99% by HPLC. CAS No. 180713-37-5. Molecular formula: C26H36O3. Mole weight: 396.56. | |
| LG 101506 | LG 101506 is a selective RXR modulator. Synonyms: LG 101506; LG101506; LG-101506; (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid. Grades: ≥98% by HPLC. CAS No. 331248-11-4. Molecular formula: C25H34F2O3. Mole weight: 420.53. | |
| LG190155 | LG190155 is a moderately potent VDR agonist. Synonyms: 1,1'-((pentane-3,3-diylbis(2-methyl-4,1-phenylene))bis(oxy))bis(3,3-dimethylbutan-2-one); LG190155; LG-190155; LG 190155; CAS# 233268-78-5. Grades: >98%. CAS No. 233268-78-5. Molecular formula: C31H44O4. Mole weight: 480.69. | |
| LGD-2226 | LGD-2226 is a selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis, shows to have an anabolic effect on muscle and bone tissue. Uses: A selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Synonyms: LGD 2941; LGD2941; LGD-2941; LGD-2226; LGD2226; LGD 2226.6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone. Grades: ≥98%. CAS No. 328947-93-9. Molecular formula: C14H9F9N2O. Mole weight: 392.22. | |
| LGD-6972 | LGD-6972 is an orally bioavailable small molecule glucagon receptor antagonist being developed as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. Synonyms: LGD-6972; LGD 6972; LGD6972; 2- [ [4- [ (2R) -2- [4- (4-tert-butylphenyl) phenyl] -3-oxo-3- [4- (2, 4, 6-trimethylphenyl) anilino] propyl] benzoyl] amino] ethanesulfonic acid. CAS No. 1207989-09-0. Molecular formula: C43H46N2O5S. Mole weight: 702.9. | |
| LH 21 | LH 21 is a CB1 receptor antagonist with poor brain-penetration. It inhibits food intake and body weight in rats by intraperitoneal administration via modulation of visceral adipose tissue, which may contribute to obesity therapy. Synonyms: LH-21; LH21; 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1,2,4-triazole. Grades: ≥98%. CAS No. 611207-11-5. Molecular formula: C20H20Cl3N3. Mole weight: 408.8. | |
| Liafensine | This active molecular is a SNDR (serotonin-norepinephrine-dopamine reuptake) inhibitor It was originated by Bristol-Myers Squibb for the treatment of major depressive disorder. In Feb 2013, Phase-II clinical trials in Major depressive disorder (treatment-experienced) in Argentina was on going. In May 2013, Bristol-Myers Squibb completed a phase II trial in Argentina, Australia, Austria, Canada, France, India, Italy, Puerto Rico, South Africa, Spain, United Kingdom and USA. In Oct 2013, Bristol-Myers Squibb discontinued a phase II trial in Major depressive disorder (treatment resistant) because of its increased capacity for side effects as well as potential for abuse. Uses: The treatment of major depressive disorder. Synonyms: 6-[(4S)-2-methyl-4-naphthalen-2-yl-3,4-dihydro-1H-isoquinolin-7-yl]pyridazin-3-amine;BMS-820836; BMS 820836; BMS820836; Liafensine. Grades: 98%. CAS No. 1198790-53-2. Molecular formula: C24H22N4. Mole weight: 366.47. | |
| Lifirafenib | Lifirafenib is a Raf monomer and dimer inhibitor. It has been developed for the treatment of solid tumors. Synonyms: BGB-283; Beigene-283. CAS No. 1446090-79-4. Molecular formula: C25H17F3N4O3. Mole weight: 478.42. | |
| Linaprazan | Linaprazan is an acid-suppressing compound with a rapid onset of action and potent acid inhibition. It inhibits gastric H+, K+-ATPase by K+-competitive binding. Synonyms: Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl-; 2, 3-Dimethyl-8-[ (2, 6-dimethylbenzyl) amino]-6-[N- (2-hydroxyethyl) aminocarbonyl]imidazo[1, 2-a]pyridine; AZD 0865; AZD-0865; AZD0865; 8-((2,6-dimethylbenzyl)amino)-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide. Grades: 98%. CAS No. 248919-64-4. Molecular formula: C21H26N4O2. Mole weight: 366.46. | |
| Linaprazan mesylate | Linaprazan can inhibit gastric H(+),K(+)-ATPase activity (IC 50: 1.0 ± 0.2 μM) and acid formation in vitro. Phase II clinical trials for the treatment of Gastroesophageal reflux disease (GERD) were discontinued. Uses: Gastroesophageal reflux disease (gerd). Synonyms: AR-h044277AW; AZD-0865 mesilate; AZD 0865 mesilate; AZD0865 mesilate; AZD-0865 mesylate; AZD 0865 mesylate; AZD0865 mesylate; Linaprazan mesilate; 8-((2,6-dimethylbenzyl)amino)-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide methanesulfonate;248919-64-4(base). Grades: 98%. CAS No. 855998-67-3. Molecular formula: C22H30N4O5S. Mole weight: 462.57. | |
| Linoleoyl ethanolamide | Linoleoyl ethanolamide is an endocannabinoid with weak affinity for CB1 and CB2 receptors. In mouse RAW264.7 macrophages, linoleoyl ethanolamide inhibited NF-κB signaling and exhibited potent anti-inflammatory effects, suggesting that it has the potential for the treatment of contact dermatitis. Synonyms: Linoleamide MEA; Linoleic ethanolamide; n-linoleoylethanolamine; N-(2-Hydroxyethyl)linoleamide; (9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide. Grades: ≥98%. CAS No. 68171-52-8. Molecular formula: C20H37NO2. Mole weight: 323.5. | |
| Linopirdine | Linopirdine is an enhancer of the release of several neurotransmitters, affecting neurotransmission and being used as a cognitive enhancer for the treatment of neurological disorders including Alzheimer's disease, Parkinsonism, and depression. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking M-type (Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 μM. Uses: Potassium channel blockers. Synonyms: 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-; 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one; DuP 996; 1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one; 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one. Grades: ≥98%. CAS No. 105431-72-9. Molecular formula: C26H21N3O. Mole weight: 391.46. | |
| Linopirdine dihydrochloride | Linopirdine dihydrochloride is a blocker of KV7 voltage-gated potassium channels. It can block KV7.1 + 7.3 (KCNQ2 + 3) / M-currents with IC50 value from 4 to 7 μM and KV7.1 homomeric channels with IC50 value of 8.9 μM. Synonyms: Linopirdine Dihydrochloride; Linopirdine 2HCl; DuP-996 Dihydrochloride; DuP996 Dihydrochloride; DuP 996 Dihydrochloride; DuP-996 2HCl; DuP996 2HCl; DuP 996 2HCl; 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 113168-57-3. Molecular formula: C26H21N3O.2HCl. Mole weight: 464.39. | |
| Linsitinib | Linsitinib, also known as OSI-906, is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis. Synonyms: OSI-906; OSI906; OSI 906. CAS No. 867160-71-2. Molecular formula: C26H23N5O. Mole weight: 421.504. | |
| Lintopride | Lintopride, also called as ACEMM, a new benzamid, is a 5HT4 antagonist with moderate 5HT3 antagonist properties that increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Synonyms: 4-amino-5-chloro-N-[(1-ethyl-4,5-dihydroimidazol-2-yl)methyl]-2-methoxybenzamide; 4-amino-5-chloro-N-((1-ethylimidazolin-2-yl)methyl); 2-methoxybenzamide; ACEMM; lintopride. CAS No. 107429-63-0. Molecular formula: C14H19ClN4O2. Mole weight: 310.78. | |
| Liranaftate | Liranaftate is a squalene epoxidase inhibitor exhabing anti-fungicidal activities. Synonyms: Liranaftate; M-732; M 732; M732; Piritetrate. Grades: >98%. CAS No. 88678-31-3. Molecular formula: C18H20N2O2S. Mole weight: 328.43. | |
| Lirilumab | A fully humanized monoclonal antibody against killer-cell immunoglobulin-like receptors (KIR), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, lirilumab binds to KIR, thereby preventing the binding of KIR ligands to KIR on natural killer (NK) cells. By blocking these inhibitory receptors, NK cells become activated and attack cancer cells leading to tumor cell death. KIR, a member of the immunoglobulin superfamily, is expressed on the surface of NK cells. Synonyms: Anti-KIR (1-7F9); Anti-KIR monoclonal antibody - Innate Pharma; BMS-986015; BMS 986015; BMS986015; IPH-21; IPH 21; IPH21; IPH-2101; IPH2102; IPH 2102;LIRI; NN 1975; NN1975; NN-1975. CAS No. 1000676-41-4. | |
| L-Isoproterenol Sulphate | The sulphate salt of isoproterenol, a β-adrenoreceptor agonist used to treat heart block. Synonyms: L-4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol Sulphate. Molecular formula: C11H19NO7S. Mole weight: 309.34. | |
| Lisuride | Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antiparkinsonian studies. Synonyms: LISURIDE;S-(-)-LISURIDE;CABERQOLINE;3-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-1,1-diethylurea;Lysuride;Methylergol carbamide;N'-[(5β)-9,10-Didehydro-6-methylergoline-8α-yl]-N,N-diethylurea;Lisuride (S)(-). Grades: 98%. CAS No. 18016-80-3. Molecular formula: C20H26N4O. Mole weight: 338.45. | |
| Lisuride maleate | Lisuride maleate, an ergot derivative, is a nonselective dopamine receptor agonist with high affinity for D2, D3 and D4 receptors along with 5-HT1A. As an anti-Parkinson's agent with anticonvulsive effects, Lisuride maleate has been shown to decrease the release of prolactin and reduce inflammatory mediators such as IL6 and TNF-&alpha. Synonyms: 3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]-1,1-diethylurea;(Z)-but-2-enedioic acid; Lisuride Maleate ; Cuvalit; Lysenyl; Lysenyl bimaleate; Lysenyl hydrogen maleate; Lisuride hydrogen maleate; Mesylate, Lisuride; Methylergol ;Carbamide Revanil. Grades: >99 %. CAS No. 19875-60-6. Molecular formula: C25H31N3O5. Mole weight: 454.58. | |
| Litorin | Litorin is an amphibian bombesin-like peptide. It can stimulate smooth muscle contraction, gastrin release, gastric acid and pancreatic secretion, and suppress food intake in vivo. Synonyms: L-pyroglutamyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide. Grades: ≥95%. CAS No. 55749-97-8. Molecular formula: C51H68N14O11S. Mole weight: 1085.25. | |
| Litronesib | litronesib, also known as LY2523355, is an inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance. Synonyms: litronesib; LY2523355; KF89617; LY 2523355; KF 89617; LY-2523355; KF-89617. CAS No. 910634-41-2. Molecular formula: C23H37N5O4S2. Mole weight: 511.7. | |
| LLY-507 | LLY-507, a lysine N-methyltransferase, is a cell-active, small molecule, and selective inhibitor of Protein-lysine Methyltransferase SMYD2 (IC50 = 15 nM), with >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Synonyms: LLY-507; LLY 507; LLY507; 5-cyano-2'-(4-(2-(3-methyl-1H-indol-1-yl)ethyl)piperazin-1-yl)-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide; LLY-507; LLY 507; LLY507. CAS No. 1793053-37-8. Molecular formula: C36H42N6O. Mole weight: 574.77. | |
| LM22B-10 | LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, which activates hippocampal and striatal TrkB and TrkC, and their downstream signaling, and increased hippocampal dendritic spine density. Synonyms: LM22B-10; LM22B 10; LM22B10; LM 22B10; LM-22B10; LM22B10; 2-[4-[[4-[bis(2-hydroxyethyl)amino]phenyl]-(4-chlorophenyl)methyl]-N-(2-hydroxyethyl)anilino]ethanol. CAS No. 342777-54-2. Molecular formula: C27H33ClN2O4. Mole weight: 485.01. | |
| LMK-235 | LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively). Uses: Histone deacetylase inhibitors. Synonyms: LMK-235; LMK 235; LMK235. Grades: 0.98. CAS No. 1418033-25-6. Molecular formula: C15H22N2O4. Mole weight: 294.351. | |
| L-NIL dihydrochloride | L-NIL is a relatively selective inhibitor of iNOS. It prevented ischemic-induced renal microvascular hypoxia via inhibiting iNOS-dependent early changes in renal oxygenation which disrupts the balance between microvascular oxygen supply and Vo(2)(ren). Synonyms: N-Iminoethyl-L-lysine dihydrochloride; L-N6-(1-Iminoethyl)lysine dihydrochloride. Grades: ≥95%. CAS No. 159190-45-1. Molecular formula: C8H17N3O2·2HCl. Mole weight: 260.2. | |
| L-NIL hydrochloride | L-NIL hydrochloride is a nitric oxide synthase inhibitor with IC50 value of 3.3 μM. Synonyms: L-NIL;N6-(1-Iminoethyl)-L-lysine hydrochloride. Grades: ≥95% by HPLC. CAS No. 150403-89-7. Molecular formula: C8H17N3O2.HCl. Mole weight: 223.7. | |
| L-NIO dihydrochloride | L-NIO dihydrochloride is a nitric oxide synthase inhibitor. It can inhibit iNOS, eNOS and nNOS. Active in vivo. Synonyms: N5-(1-Iminoethyl)-L-ornithine dihydrochloride. Grades: ≥95% by HPLC. CAS No. 159190-44-0. Molecular formula: C7H15N3O2.2HCl. Mole weight: 246.13. | |
| L-NIO hydrochloride | L-NIO is an irreversible and non-selective inhibitor of all NOS isoforms. Synonyms: L-NIO;N5-iminoethyl-l-ornithine hydrochloride; N5-(1-Iminoethyl)-L-ornithine hydrochloride; N(G)-Iminoethylornithine hydrochloride. Grades: ≥95%. CAS No. 36889-13-1. Molecular formula: C7H15N3O2·2HCl. Mole weight: 246.1. | |
| L-NMMA citrate | L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared. L-NMMA may contribute to the therapy of patients with cardiogenic shock. Synonyms: L-NG-monomethyl arginine citrate. Grades: ≥99%. Molecular formula: 3[C7H16N4O2]·C6H8O7. Mole weight: 756.8. | |
| Locostatin | Locostatin is a cell-permeable N-(crotonyl)oxazolidinone compound that acts as a potent inhibitor of RKIP (Raf kinase inhibitor protein)/Raf-1 kinase interaction. Synonyms: (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one; (N-Crotonyl)-(4S)-benzyl-2-oxazolidinone. Grades: 95%. CAS No. 133812-16-5. Molecular formula: C14H15NO3. Mole weight: 245.27. | |
| Lofepramine | Lofepramine is a serotonin and noradrenalin reuptake inhibitor as an antidepressant. Synonyms: 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone. Grades: ≥99% by HPLC. CAS No. 23047-25-8. Molecular formula: C26H27N2OCl. Mole weight: 418.97. | |
| Lofexidine hydrochloride | Lofexidine hydrochloride is the hydrochloride salt form of Lofexidine. Lofexidine, an analogue of clonidine, is an α2A-adrenergic receptor agonist for the treatment of opioid withdrawal symptoms as well as an anihypertensive. Uses: α2-adrenoceptor agonist related structurally to clonidine. used in treatment of opioid withdrawal symptoms; antihypertensive. Synonyms: 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride 2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline BritLofex lofexidine lofexidine hydrochloride Lofexidine mono-hydrochloride lofexidine monohydrochloride lofexidine, (+-)-isom. Grades: ≥98%. CAS No. 21498-08-8. Molecular formula: C11H13Cl3N2O. Mole weight: 295.59. | |
| Lomefloxacin | Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms, which is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice1 and modification of the kinetics of growth of Gram-negative bacteria. It inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. Uses: Anti-bacterial agents. Synonyms: Maxaquin; SC47111A. Grades: >98%. CAS No. 98079-51-7. Molecular formula: C17H19F2N3O3. Mole weight: 351.35. | |
| Longdaysin | Longdaysin is an inhibitor of protein kinases including CKIδ, CKIα, ERK2 and CDK7 with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM, respectively. Longdaysin inhibits Wnt/β-catenin signaling pathway and exhibits antitumor activity. Synonyms: 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine. CAS No. 1353867-91-0. Molecular formula: C16H16F3N5. Mole weight: 335.33. | |
| Lopixibat chloride | Lopixibat, also called as LUM-001 and Maralixibat, is an inhibitor of the sodium bile acid cotransporter and a selective Ileal bile acid transporter inhibitor. Lopixibat is in development for the treatment of cholestatic liver disorders in paediatric and adult patients. Synonyms: (4R,5R)-5-[4-[[4-(1-aza-4-azoniabicyclo[2.2.2]octan-4-ylmethyl)phenyl]methoxy]phenyl]-3,3-dibutyl-7-(dimethylamino)-1,1-dioxo-4,5-dihydro-2H-1$l^{6}-benzothiepin-4-ol;chloride; LUM-001; LUM001; LUM 001; SHP-625; SHP 625; SHP625; Lopixibat chloride. Grades: >98%. CAS No. 228113-66-4. Molecular formula: C40H56ClN3O4S. Mole weight: 710.41. | |
| LOR-253 | LOR-253 is a novel small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Krüppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. It demonstrats potent and selective growth inhibition of a variety of solid tumor cell lines, including colon cancer, non-small cell lung cancer (NSCLC), prostate cancer and melanoma in vitro. It demonstrats even great potency of growth inhibitory activity against leukemia cell lines, including AML, ALL and chronic myeloid leukemia (CML), as well as non-Hodgkin's lymphoma (NHL) cell lines. It exerts in vivoanti-tumor activity in solid tumors and hematologic cancers in vivo. It was developed by Aptose Biosciences and has been Cilinic Phase 1. Uses: Lor-253 has anti-tumor activity in cancer cells. it demonstrats potent and selective growth inhibition of a variety of solid tumor cell lines. Synonyms: LOR-253;APTO-253;CS-5226;LT-253; LOR 253;APTO 253;CS 5226;LT 253; LOR253;APTO253;CS5226;LT253; 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline. Grades: >98%. CAS No. 916151-99-0. Molecular formula: C22H14FN5. Mole weight: 367.38. | |
| Loreclezole hydrochloride | Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator. It acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Synonyms: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride. Grades: ≥99% by HPLC. CAS No. 117857-45-1. Molecular formula: C10H6Cl3N3.HCl. Mole weight: 311. | |
| Lorediplon | Lorediplon is a hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit. It is a novel nonbenzodiazepine of the pyrazolopyrimidine family. It is a drug for the treatment of insomnia. It demonstrated a dose-dependent improvement in sleep. It has been successfully completed with a best-in-class efficacy profile in terms of maintaining sleep and sleep quality. It demonstrates a minimum of 10-fold and 6-fold increase in potency in the spontaneous motor activation studies. It was developed by Ferrer and has been in Cilinic Phase 2. Uses: Lorediplon is a drug for the treatment of insomnia. Synonyms: Acetamide, N-(2-fluoro-5-(3-(2-thienylcarbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methyl-;N-(2-Fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methylacetamide. Grades: >98%. CAS No. 917393-39-6. Molecular formula: C20H15FN4O2S. Mole weight: 394.42. | |
| Loxapine Succinate | Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.oxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. Trade names for loxapine taken by mouth include Loxapac and Loxitane; the inhalable form is approved as Adasuve. Synonyms: Loxapine Succinate. Grades: >98%. CAS No. 27833-64-3. Molecular formula: C18H18ClN3O.C4H6O4. Mole weight: 445.9. | |
| LOXO-195 | LOXO-195 is an orally available inhibitor of the tyrosine receptor kinases (TRK). It binds to TRK including the fusion proteins containing sequences from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1), 2 (NTRK2), and 3 (NTRK3), which inhibits the interaction of neurotrophin and TRK, inducing cell apoptosis in tumors overexpressing TRK and NTRK. Uses: Enzyme inhibitors. Synonyms: Selitrectinib. Grades: ≥98%. CAS No. 2097002-61-2. Molecular formula: C20H21FN6O. Mole weight: 380.42. | |
| Loxoprofen Sodium | The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration. Synonyms: More Synonyms. Grades: >98%. CAS No. 80382-23-6. Molecular formula: C15H17NaO3. Mole weight: 268.28. | |
| LP 12 hydrochloride | LP 12 hydrochloride is a 5-HT7 receptor agonist. It can induce relaxation of substance P-induced contractions in guinea pig ileum with EC50 value of 1.77 μM. Synonyms: LP 12 hydrochloride; LP12 hydrochloride; LP-12 hydrochloride; 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1185136-22-4. Molecular formula: C32H39N3O.HCl. Mole weight: 518.13. | |
| LP 20 hydrochloride | LP 20 hydrochloride is a ligand of the 5-HT7 receptor. It shows agonist and antagonist activity. Synonyms: LP 20 hydrochloride; LP20 hydrochloride; LP-20 hydrochloride; 1-(4'-Methoxy[1,1-biphenyl]-2-yl)piperazine hydrochloride. Grades: ≥98% by HPLC. CAS No. 1386928-34-2. Molecular formula: C17H20N2O.HCl. Mole weight: 304.81. | |
| LP 44 | LP 44 is a 5-HT7 receptor agonist with Ki value of 0.22 nM that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). It induces relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 μM. Synonyms: LP-44; LP 44; LP44; 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 824958-12-5. Molecular formula: C27H37N3OS.HCl. Mole weight: 488.13. | |
| LP-533401 | LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that suppresses serotonin production in the gut. It prevents the development of osteoporosis in ovariectomized and aged mice. Synonyms: (2S)-2-Amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-[4-(3-fluorophenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid. Grades: ≥98%. CAS No. 945976-43-2. Molecular formula: C27H22F4N4O3. Mole weight: 526.5. | |
| LP99 | LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 inhibitor may have a similar function and utility to IL-6 neutralizing antibodies, such as tocilizumab, in the treatment of rheumatoid arthritis. Synonyms: N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamideN-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamideN-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamideGTPL8572; GTPL 8572; GTPL-8572; LP99; LP-99; LP 99. Grades: >98%. CAS No. 1808951-93-0. Molecular formula: C26H30ClN3O4S. Mole weight: 516.05. | |
| L-Phenylephrine | L-Phenylephrine is an α1 adrenergic receptor agonist (Ki = 1.4 μM) with selectivity for α1A over α1B and α1C receptor subtypes (Ki = 1.4, 23.9 and 47.8 μM, respectively). L-Phenylephrine has been used as a cardiotonic drug, mydriatic agent, vasoconstrictor agent, sympathomimetic agent and nasal decongestant. Synonyms: (R)-(-)-Phenylephrine; phenylephrine; Metasympatol; Mezaton; 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol. Grades: ≥98%. CAS No. 59-42-7. Molecular formula: C9H13NO2. Mole weight: 167.2. | |
| LRRK2-IN-1 | LRRK2-IN-1 is a benzodiazepine based derivative and is known as a selective inhibitor of the Parkinson's disease kinase LRRK2. Synonyms: LRRK2-IN-1; LRRK2-IN 1; LRRK2-IN1. Grades: >98%. CAS No. 1234480-84-2. Molecular formula: C31H38N8O3. Mole weight: 570.69. | |
| LSN 2463359 | LSN 2463359 is an allosteric modulator at the mGlu5 receptor with EC50 value of 24 nM. It is brain penetrant and can reverse learning deficits in a rat model of schizophrenia. LSN 2463359 can also promote wakefulness in animals. Synonyms: LSN2463359; LSN-2463359; LSN 2463359; N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide. Grades: ≥99% by HPLC. CAS No. 1401031-52-4. Molecular formula: C16H15N3O. Mole weight: 265.31. | |
| LSPN451 | LSPN451, was selected from a series of 10 synthetic derivatives, is a novel potent xanthine oxidase inhibitor may be potentially useful for the treatment of hyperuricemia and gout. Xanthine oxidase inhibition (XOI) reduces oxidative stress in the vasculature. Uses: Xanthine oxidase inhibitor. Synonyms: LSPN451; LSPN-451; LSPN 451. 3-Nitrobenzoyl 9-deazaguanine;2-amino-7-(3-nitrobenzoyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one. Grades: ≥98%. CAS No. 474555-58-3. Molecular formula: C13H9N5O4. Mole weight: 299.24. | |
| L-Stepholidine | L-Stepholidine, naturally occured herbal constituent of Stephania intermedia, with the potential to treat neural diseases including dyskinesia, parkinsonism, schizophrenia, is an antagonist D2 receptor with dual affinity for agonist of D1 receptor recepto. Uses: Antipsychotic agents. Synonyms: (13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol l-Stepholidine 16562-13-3 stepholidine (-)-Stepholidine (S)-3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,10-diol S-Stepholidine UNII-0UPX3E. Grades: >98%. CAS No. 16562-13-3. Molecular formula: C19H21NO4. Mole weight: 327.37. | |
| LT175 | LT175 is a dual PPARα/γ ligand with partial agonist activity against PPAR&gamma. LT175 exhibits low adipogenic activity, and decreased body weight, adipocyte size, and white adipose tissue mass in mice fed a high-fat diet. It improves glucose homeostasis and insulin sensitivity. Synonyms: (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid. Grades: ≥98%. CAS No. 862901-87-9. Molecular formula: C21H18O3. Mole weight: 318.4. | |
| L-threo-sphingosine (d18:1) | L-threo-Sphingosine (d18:1), an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length. Synonyms: (2S,3S,4E)-2-aminooctadec-4-ene-1,3-diol; 3-L-4-Sphingenine. Grades: >98%. CAS No. 25695-95-8. Molecular formula: C18H37NO2. Mole weight: 299.49. | |
| LTURM 36 | LTURM 36 is a PI3-kinase δ inhibitor with IC50 value of 0.64μM. It shows anticancer activity in a renal cancer cell line. Synonyms: LTURM-36; LTURM 36; LTURM36; 2-(4-Morpholinyl)-8-(1-naphthalenyl)-4H-1,3-benzoxazin-4-one. Grades: ≥98% by HPLC. CAS No. 1879887-94-1. Molecular formula: C22H18N2O3. Mole weight: 358.39. | |
| LU AA33810 | LU AA33810 is a neuropeptide Y Y5 receptor antagonist. It exhibits anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. Synonyms: N- [ [trans-4- [ (4, 5-Dihydro [1] benzothiepino [5, 4-d] thiazol-2-yl) amino] cyclohexyl] methyl] methanesulfonamide. Grades: ≥98% by HPLC. CAS No. 304008-29-5. Molecular formula: C19H25N3O2S3. Mole weight: 423.62. | |
| Lu AA 47070 | Lu AA 47070 is a prodrug of a potent and selective adenosine A2A receptor antagonist. Synonyms: Lu-AA47070; Lu AA47070; LuAA47070; 4-[(3,3-Dimethyl-1-oxobutyl)amino]-3,5-difluoro-N-[3-[(phosphonooxy)methyl]-2(3H)-thiazolylidene]benzamide. CAS No. 913842-25-8. Molecular formula: C17H20F2N3O6PS. Mole weight: 463.39. | |
| Lu AF21934 | Lu AF21934 is a selective and brain-penetrating positive allosteric modulator (PAM) of mGlu4 receptors (IC50 = 500 nM) on the harmaline-induced tremor and other forms of motor activity in rats using fully automated Force Plate Actimeters. Synonyms: Lu AF21934; Lu AF-21934; Lu AF 21934; Lu-AF21934; Lu-AF-21934; Lu-AF 21934; LuAF21934; LuAF-21934; LuAF 21934; (1R,2S)-2-N-(3,4-dichlorophenyl)cyclohexane-1,2-dicarboxamide; Lu AF21934; N1-(3,4-dichlorophenyl)-cyclohexane-1,2-dicarboxamide. CAS No. 1445605-23-1. Molecular formula: C14H16Cl2N2O2. Mole weight: 315.2. | |
| Lucitanib | Lucitanib, also known as E-3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. Synonyms: E3810; E-3810; E 3810; AL3810; AL 3810; AL-3810; Lucitanib. CAS No. 1058137-23-7. Molecular formula: C26H25N3O4. Mole weight: 443.503. | |
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