BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Isobavachalcone | Isobavachalcone is a naturally occurring chalcone mainly isolated from the seeds of Psoralea corylifolia Linn. Isobavachalcone inhibits Akt signaling pathway, inducing apoptosis in human cancer cells. Uses: Anti-inflammatory. Synonyms: Corylifolinin; Isobacachalcone. Grades: >98%. CAS No. 20784-50-3. Molecular formula: C20H20O4. Mole weight: 324.37. |  |
| Isoborneol | Isoborneol is a monoterpene that can be isolated from a variety of plants. It is used as a flavor in food additive. Isoborneol acts as an inhibitor of herpes simplex virus type 1 (HSV-1) replication. It also exhibits antitumor and neuroprotective effects. Uses: Antiviral reagents. Synonyms: Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1R,2R,4R)-rel-; Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, exo-; (±)-Isoborneol; 2-exo-Bornyl alcohol; DL-Isoborneol; dl-Isoborneol; exo-2-Hydroxy-1,7,7-trimethylnorbornane; Isobornyl alcohol; NSC 26350. Grades: ≥95%. CAS No. 124-76-5. Molecular formula: C10H18O. Mole weight: 154.25. | |
| Isocarboxazid | Isocarboxazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class. It is primarily used to treat mood and anxiety disorders. It is also used for the treatment of Parkinson's disease and other dementia-related disorders. It is also effective in the treatment of major depression, dysthymic disorder, and atypical depression. It blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine at central aminergic receptors. It was developed by Validus and has been listed. Uses: Isocarboxazid is primarily used to treat mood and anxiety disorders. it is also used for the treatment of parkinson's disease and other dementia-related disorders. it is also effective in the treatment of major depression, dysthymic disorder, and atypical. Synonyms: 1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine;3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide;3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide;5-Methyl-3-isoxazole-carboxylic Acid 2-Benzylhydrazide;3-(N-Benzylhydrazinocarbon. Grades: 95%. CAS No. 59-63-2. Molecular formula: C12H13N3O2. Mole weight: 231.25. | |
| Isoetarine | Isoetarine is a selective adrenergic beta-2 agonist. It is used as fast acting bronchodilator for emphysema, bronchitis and asthma. It has been listed. Uses: Isoetarine is used as fast acting bronchodilator for emphysema, bronchitis and asthma. Synonyms: Dilabron;Etyprenaline;Neoisuprel;WIN-3406;Bronkometer;4-[1-Hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol;Bronkosol;Etyprenalinum. Grades: 98%. CAS No. 530-08-5. Molecular formula: C13H21NO3. Mole weight: 239.31. | |
| Isoetharine mesylate | Isoetharine is a selective beta2-adrenergic receptor agonist, which is approved for the treatment of emphysema, bronchitis and asthma. Synonyms: Isoetharine mesylate salt. Grades: 95%. CAS No. 7279-75-6. Molecular formula: C14H25NO6S. Mole weight: 335.42. | |
| Isofagomine D-Tartrate | The D-Tartrate salt form of Isofagomine, an imino pyranose compound, has been found to be a glucosylceramidase stimulant and could exhibit activity in Gaucher's disease. Synonyms: (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol (2S,3S)-2,3-dihydroxysuccinate; AT2101; AT-2101, AT 2101; Isofagomine D-Tartrate; Isofagomine; Afegostat; D-Isofagomine; isoFagomine brand name: Plicera. Grades: 98%. CAS No. 957230-65-8. Molecular formula: C10H19NO9. Mole weight: 297.26. | |
| Isoguvacine hydrochloride | Isoguvacine hydrochloride is a selective GABA receptor agonist with anticonvulsant and antiepileptic effect, developed for Neuroscience research. Synonyms: Iso Guvacine Hydrochloride; 4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-, hydrochloride (1:1); 4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-, hydrochloride; Isoguvacine monohydrochloride; 1,2,3,6-Tetrahydro-4-pyridinecarboxylic Acid Hydrochloride. Grades: ≥95%. CAS No. 68547-97-7. Molecular formula: C6H10ClNO2. Mole weight: 163.60. | |
| Isoniazid/INH | Cas No. 54-85-3. | |
| Isonipecotic acid | Isonipecotic acid is a GABAA receptor partial agonist. Synonyms: 4-Piperidinecarboxylic acid; 4-Carboxypiperidine; Hexahydroisonicotinic acid; 4-Hexahydroisonicotinic acid; NSC 61049; H-Inp-OH; Isonipecotinic Acid. Grades: ≥95%. CAS No. 498-94-2. Molecular formula: C6H11NO2. Mole weight: 129.16. | |
| Iso-olomoucine | Iso-olomoucine is an inactive stereoisomer of olomoucine, a cyclin-dependent kinase (CDK) inhibitor. Olomoucine competitively inhibits the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. Iso-olomoucine can be a negative control compound of olomoucine. Synonyms: 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine; 2-[[6-(benzylamino)-7-methylpurin-2-yl]amino]ethanol. Grades: ≥98%. CAS No. 101622-50-8. Molecular formula: C15H18N6O. Mole weight: 298.3. | |
| iso-PPADS tetrasodium salt | iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS, which blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1-2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. Synonyms: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt. CAS No. 207572-67-6. Molecular formula: C14H10N3Na4O12PS2. Mole weight: 599.3. | |
| Isopropamide Iodide | Isopropamide Iodide is an anticholinergic compound and a muscarinic receptor antagonist, which can be used for Alzheimer's disease treatment. Synonyms: Darbid; (4-amino-4-oxo-3,3-diphenylbutyl)-methyl-di(propan-2-yl)azanium iodide. CAS No. 71-81-8. Molecular formula: C23H33IN2O. Mole weight: 480.434. | |
| Isopropyl dodec-11-enylfluorophosphonate | Isopropyl dodec-11-enylfluorophosphonate is a central cannabinoid (CB1) receptor antagonist and inhibits FAAH with similar potencies (IC50s = 2 nM). Synonyms: 12-[fluoro(propan-2-yloxy)phosphoryl]dodec-1-ene. Grades: ≥98%. CAS No. 623114-64-7. Molecular formula: C15H30FO2P. Mole weight: 292.4. | |
| isoproterenol | Isoproterenol can be used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. It is a non-selective β adrenoreceptor agonist and TAAR1 agonist that is structurally similar to epinephrine. Uses: Sympathomimetics. Synonyms: 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-; 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol; (±)-Isoprenaline; (±)-Isoproterenol; 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol; 3,4-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol; DL-(±)-Isoproterenol; DL-Isopropylnorepinephrine; DL-Isoproterenol; A 21; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; dl-Isadrine; dl-Isoprenaline; dl-N-Isopropylnoradrenaline; Epinephrine isopropyl homolog; ICI 46399; Isonorin; Isoprenalin; Isoprenaline; Isopropydrin; Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isorenin; Isupren; Lomupren; N-Isopropyl-β-dihydroxyphenyl-β-hydroxyethylamine; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine; Neo-Epinine; Neodrenal; Norisodrine; NSC 33791; NSC 9975; Racemic isoprenaline; Racemic isoproterenol; Respifral; Vapo-N-Iso; α - (Isopropylaminomoethyl) protocatechuyl alcohol. Grades: 98%. CAS No. 7683-59-2. Molecular formula: C11H17NO3. Mole weight: 211.26. | |
| Isoproterenol sulfate | Isoproterenol is a non-selective β adrenoreceptor agonist indicated for the treatment of heart block and Stoke-Adams syndrome. Uses: Cardiotonic agents. Synonyms: 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, sulfate (2:1); 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, sulfate (2:1) (salt); Benzyl alcohol, 3,4-dihydroxy-α-[(isopropylamino)methyl]-, sulfate (2:1) (salt); (±)-Isoprenaline sulfate; (±)-Isoproterenol sulfate; 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol sulfate (2:1); Aleudrin; dl-Isoprenaline sulfate; dl-Isoproterenol sulfate; dl-α-3,4-Dihydroxyphenyl-β-iso-propylaminoethanol sulfate; Isoprenaline sulfate; Isoprenaline sulfate (2:1); Isopropylnoradrenaline sulfate; Isoproterenol sulfate (2:1); Medihaler-ISO; N-Isopropylnorepinephrine sulfate; Novodrin; Novodrine. Grades: ≥95%. CAS No. 299-95-6. Molecular formula: C11H17NO3.1/2H2O4S. Mole weight: 520.60. | |
| Isosorbide | Isosorbide is a heterocyclic compound that is derived from glucose, used as a diuretic. Synonyms: 1,4,3,6-Dianhydrosorbitol; D-Isosorbide; 1,4:3,6-Dianhydro-D-sorbitol. Grades: 98%. CAS No. 652-67-5. Molecular formula: C6H10O4. Mole weight: 146.14. | |
| Isothipendyl | Isothipendyl is a first-generation histamine H1 antagonist with anticholinergic activity. It has been used as an antipruritic. Synonyms: Andanton; Nilergex; Odantol; Udantol; N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine. CAS No. 482-15-5. Molecular formula: C16H19N3S. Mole weight: 285.41. | |
| Isothipendyl hydrochloride | Isothipendyl is a first-generation histamine H1 antagonist with anticholinergic activity. It has been used as an antipruritic. Uses: Histamine antagonists. Synonyms: Andantol; Theruhistin; Adantol; Isothipendyl HCl; N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine hydrochloride. CAS No. 1225-60-1. Molecular formula: C16H20ClN3S. Mole weight: 321.867. | |
| ISOX DUAL | ISOX DUAL is a potent inhibitor of bromodomain-containing protein 4 (BRD4), as well as the bromodomain of CREB binding protein (CBP). Its IC50 values are 1.5 and 0.65 μM for BRD4 and CBP respectively. It downregulates IL-6, IL-1β and IFN-β in macrophages. Synonyms: [3- [4- [2- [5- (Dimethyl-1, 2-oxazol-4-yl) -1- [2- (morpholin-4-yl) ethyl] -1H-1, 3-benzodiazol-2-yl] ethyl] phenoxy] propyl] dimethylamine. Grades: ≥98% by HPLC. CAS No. 1962928-22-8. Molecular formula: C31H41N5O3. Mole weight: 531.69. | |
| ISOX INACT | ISOX INACT is an inactive control probe of the bromodomain of CREB binding protein (CBP) PF-CBP1. It shows negligible activity at CBP and BRD4. It was used to prepare and discover potent and selective in vivo probe for bromodomains of CBP/EP300. Synonyms: 5-(Dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]--4,6-dimethyl-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazole; 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-methoxyphenethyl)-4,6-dimethyl-1Hbenzo[d]imidazol-1-yl)ethyl)morpholine. Grades: ≥98% by HPLC. Molecular formula: C29H36N4O3. Mole weight: 488.62. | |
| Isoxsuprine hydrochloride | Isoxsuprine is a β-adrenergic receptor agonist and α-adrenergic receptor. Isoxsuprine has been shown to relax vascular smooth muscle and can be used in the treatment of blood vessel diseases. It is also used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. Synonyms: Benzenemethanol, 4-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride (1:1); Benzyl alcohol, p-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride; Norephedrine, p-hydroxy-N-(1-methyl-2-phenoxyethyl)-, hydrochloride; 1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1 hydrochloride; Dilavase; Divadilan; Duvadilan; Duviculine; Isolait; Isoxsuprin hydrochloride; Navilox; Suprilent; Suprox SR; Tidilan; Vadosilan; Vasodilan; Vasoplex; Vasotran. Grades: ≥98%. CAS No. 579-56-6. Molecular formula: C18H23NO3.HCl. Mole weight: 337.84. | |
| ISS610 | ISS610 is a Signal transducer and activator of transcription 3 (STAT3) inhibitor. Reported has shown that aberrant activation of oncogenic signal transducer and activator of STAT3 protein signaling pathways is implicated in human cancers. Uses: Cancer. Synonyms: ((S)-2-(4-cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanoyl)-L-leucine. Grades: 98%. CAS No. 725233-55-6. Molecular formula: C23H26N3O8P. Mole weight: 503.45. | |
| Istaroxime | Istaroxime, also called as PST 2744, is an inhibitor of sodium-potassium ATPase that exhibits the unique property of increasing SERCA2a activity. This has been demonstrated in sarcoplasmic reticulum vesicles from normal guinea pigs, where istaroxime incre. Synonyms: PST-2744; PST 2744; PST2744; Istaroxime; (3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochlorideIstaroxi. CAS No. 203737-93-3. Molecular formula: C21H32N2O3. Mole weight: 360.49. | |
| Istaroxime hydrochloride | Istaroxime is a adenosine triphosphatase inhibitor, inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Uses: Inhibitor of na+/k+ atpase. Synonyms: PST-2744 HCl; PST 2744 HCl; PST2744 HCl(3E,5α)-3-[(2-Aminoethoxy)imino]androstane-6,17-dione hydrochloride. Grades: ≥95%. CAS No. 374559-48-5. Molecular formula: C21H33ClN2O3. Mole weight: 396.95. | |
| IT1t | IT1t is a selective CXCR4 antagonist with IC50 value of 1.1 nM in calcium mobilization assays.It may be potential useful as anti-HIV agent. Uses: Anti-hiv agent. Synonyms: N,N'-Dicyclohexylcarbamimidothioic Acid (5,6-Dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl Ester;1092776-63-0 (HCl salt). Grades: 98%. CAS No. 864677-55-4. Molecular formula: C21H34N4S2. Mole weight: 406.65. | |
| IT1t dihydrochloride | IT1t dihydrochloride is a potent and orally CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Synonyms: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride; IT1t; IT1t dihydrochloride. Grades: ≥98% (HPLC). CAS No. 1092776-63-0. Molecular formula: C21H34N4S2.2HCl. Mole weight: 479.57. | |
| ITH 12575 | ITH 12575, a potent and selective inhibitor of mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor, reduced Ca(2+) influx through CALHM1 at low micromolar concentrations. It can be used to study the physiological roles of the mitochondrial sodium /calcium exchanger related to neurodegeneration. Synonyms: ITH-12575; ITH 12575; ITH12575; 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one; ITH-12575; ITH12575. Grades: ≥98% by HPLC. CAS No. 1802013-08-6. Molecular formula: C18H18ClNOS. Mole weight: 331.86. | |
| ITK inhibitor | ITK inhibitor is a potent inhibitor of ITK. Synonyms: ITK inhibitor; 439574-61-5; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3-methylbutan-2-ylamino)methyl]benzamideBENZAMIDE, N-[5-[[5-[(4-ACETYL-1-PIPERAZINYL)CARBONYL]-4-METHOXY-2-METHYLPHENYL]THIO]-2-THIAZOLYL]-4-[[(1,2-DIMETHYLPROPYL)AMINO]METHYL]-SCHEMBL14460568. Grades: >98%. CAS No. 439574-61-5. Molecular formula: C31H39N5O4S2. Mole weight: 609.82. | |
| ITSA1 | ITSA1 is a cell-permeable HDAC activator via inhibition of trichostatin A (TSA), which is a reversible inhibitor of HDAC. ITSA1 was showed to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation. Synonyms: ITSA-1; ITSA 1; N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide. Grades: ≥95%. CAS No. 200626-61-5. Molecular formula: C13H7Cl2N3O. Mole weight: 292.1. | |
| Ivacaftor hydrate | Ivacaftor hydrate is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. Synonyms: VX-770 hydrate; N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide hydrate; 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-, hydrate (1:1); N-[5-Hydroxy-2,4-bis(2-methyl-2-propanyl)phenyl]-4-oxo-1,4-dihydro-3-quinolinecarboxamide hydrate (1:1); Kalydeco hydrate. Grades: >98%. CAS No. 1134822-07-3. Molecular formula: C24H30N2O4. Mole weight: 410.51. | |
| Ivachtin | Ivachtin is a potent and non-competitive caspase-3 inhibitor. It exhibits 10-100 fold selectivity over other caspases and more potent anti-apoptotic activity than Z-VAD-FMK. Synonyms: Caspase-3 Inhibitor VII; 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate. Grades: 99%. CAS No. 745046-84-8. Molecular formula: C20H21N3O7S. Mole weight: 447.46. | |
| IWP 12 | IWP 12 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). It blocks post resection juvenile zebrafish tailfin regeneration and is suitable for in vivo assays. It is a membrane-bound O-acyltransferase (MBOAT) and activates Wnt proteins with IC50 value of 15 nM. It inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Synonyms: IWP12; IWP 12; IWP-12; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 688353-45-9. Molecular formula: C18H18N4O2S3. Mole weight: 418.56. | |
| IWP-2-V2 | IWP-2 is an inhibitor of Wnt production (IC50 = 27 nM) that inhibits porcupine, a membrane-bound acyltransferase that is essential to the pamitoylation of Wnt ligands. IWP-2-V2 is an IWP-2 derivative with less potency. Synonyms: 2-((3-benzyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98%. CAS No. 877618-79-6. Molecular formula: C23H20N4O2S3. Mole weight: 480.6. | |
| J 104129 fumarate | The fumarate salt form of J 104129, which has been found to be a muscarinic M3 receptor antagonist with high selectivity. Synonyms: J-104129 fumarate; J 104129 fumarate; J104129 fumarate; (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate. Grades: ≥99% by HPLC. CAS No. 257603-40-0. Molecular formula: C24H36N2O2.C4H4O4. Mole weight: 500.63. | |
| J 113863 | J 113863 is a potent CCR1 antagonist. Synonyms: J 113863; J-113863; J113863; UCB 35625; UCB-35625; UCB35625; 2,7-dichloro-N-[1-(cycloocten-1-ylmethyl)-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide; iodide. CAS No. 353791-85-2. Molecular formula: C30H37Cl2IN2O2. Mole weight: 655.44. | |
| J 2156 | J 2156 is a somatostatin receptor 4 agonist with >400-fold selectivity for human sst4 over other human sst receptor subtypes. Study revealed that J 2156 reduced mechanosensitivity of peripheral nerve afferents and spinal neurons in the Complete Freund?s Adjuvant (CFA) model. Synonyms: J-2156; (1'S,2S)-4-Amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide trifluoroacetate. Grades: ≥98% by HPLC. Molecular formula: C24H28N4O4S·C2HF3O2. Mole weight: 582.6. | |
| JAK2 Inhibitor IV | JAK2 Inhibitor IV is a potent and selective Janus Kinase 2 (JAK2) inhibitor that inhibits the activity of both the wild-type JAK2 and the V617F mutant (IC50 = 78 and 206 nM, respectively). Synonyms: JAK2 inhibitor 13. Grades: 99%. CAS No. 1110502-30-1. Molecular formula: C17H20N4O2S. Mole weight: 344.43. | |
| JAK3-IN-6 | JAK3-IN-6 is a potent and highly selective JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. Synonyms: JAK3-IN-2; Ethyl 4-[3-(2-methylprop-2-enoylamino)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate. CAS No. 1443235-95-7. Molecular formula: C19H18N4O3. Mole weight: 350.37. | |
| JBJ-04-125-02 | JBJ-04-125-02 is a mutation-selective EGFR inhibitor with anti-tumor activity. Synonyms: JBJ 04-125-02; JBJ04-125-02; JBJ-0412502. Grades: ≥98% by HPLC. CAS No. 2060610-53-7. Molecular formula: C29H26FN5O3S. Mole weight: 543.6. | |
| JDTic | A 4-phenylpiperidine derivative, for the κ-opioid receptor. Uses: A selective opioid kappa receptor antagonist. Synonyms: (3R)-7-hydroxy-N-[1-[(3R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide. Grades: ≥98%. CAS No. 361444-66-8. Molecular formula: C28H39N3O3. Mole weight: 465.64. | |
| JDTic dihydrochloride | JDTic dihydrochloride is a highly selective antagonist for the κ-opioid receptor with IC50 value of 0.02nM without affecting the μ- or δ-opioid receptors. It is a 4-phenylpiperidine derivative and distantly structurally related to analgesic drugs such as meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan. It is structurally distinct from other kappa antagonists such as norbinaltorphimine. It is more selective and potent for KOR activity than other KOR antagonists. It is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. It can also block the nicotine withdrawal signs in mice vi... it can also block the nicotine withdrawal signs in mice via effecting the expression of a cpa associated with nicotine withdrawal. it is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats. it may produce antidepressant and anxiolytic effects and may be used in the treatment of addiction to cocaine and morphine. Synonyms: JDTic (2HCl);(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride;(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4- . Grades: 95%. CAS No. 785835-79-2. Molecular formula: C28H41Cl2N3O3. Mole weight: 538.55. | |
| JFD00244 | JFD00244 is an inhibitor of sirtuin 2 (SIRT2), a NAD+-dependent protein deacetylase. It induces granulocytic differentiation in the acute promyelocytic leukemia (APL) cell line NB4. Synonyms: BML-266; 1,4-Bis[(P-hydroxyphenethyl)amino]-anthraquinone. Grades: ≥95%. CAS No. 96969-83-4. Molecular formula: C30H26N2O4. Mole weight: 478.5. | |
| JF-NP-26 | JF-NP-26 is a photoactive mGlu5 receptor negative allosteric modulator. Activated by visible light, JF-NP-26 releases the active molecule (raseglurant) that blocks the mGlu5 receptor. Synonyms: (7-(Diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-yl)carbamate. Grades: ≥98% by HPLC. CAS No. 2341841-03-8. Molecular formula: C30H28FN3O4. Mole weight: 513.56. | |
| JGB1741 | JGB1741 is a small-molecule inhibitor of SIRT1, a NAD+-dependent class III histone deacetylase (HDAC) which is overexpressed in many cancer cells. JGB1741 shows potent inhibitory effects against the proliferation of human metastatic breast cancer cells, MDA-MB 231. Synonyms: ILS-JGB-1741; N-Benzyl-2-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide. Grades: ≥98%. CAS No. 1256375-38-8. Molecular formula: C27H24N2O2S. Mole weight: 440.6. | |
| JH-II-127 | JH-II-127, a Pyrrolopyrimidine derivative, is a highly potent, selective, and brain penetrant LRRK2 inhibitor, of both wild-type and G2019S mutant LRRK2. IC50: LRRK2-wild-type= 6.6 nM, LRRK2-G2019S= 2.2 nM ,LRRK2-A2016T= 47.7 nM. Synonyms: [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone JH-II-127 (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 1700693-08-8 JH-II127 JH-II. CAS No. 1700693-08-8. Molecular formula: C19H21ClN6O3. Mole weight: 416.86. | |
| JI-101 | JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis. Synonyms: N-[1-[(2-Amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)urea; 1-[1-[(2-Aminopyridin-4-yl)methyl]-1H-indol-4-yl]-3-(5-bromo-2-methoxyphenyl)urea; CGI 1842; JI101; JI 101. Grades: 98%. CAS No. 900573-88-8. Molecular formula: C22H20BrN5O2. Mole weight: 466.33. | |
| JIB-04 | JIB-04 is a potent, selective and cell-permeable inhibitor used in compound for cancer research. It targets the histone demethylase KDM5A and effectively suppresses the growth of various cancer cells like triple-negative breast cancer and acute myeloid leukemia. Synonyms: JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627. CAS No. 199596-05-9. Molecular formula: C17H13ClN4. Mole weight: 308.769. | |
| JKC 363 | JKC 363 has been found to be a melanocortin MC4 receptor antagonist and could suppress the release of thyrotropin-releasing hormone (TRH). Synonyms: (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide; JKC363; JKC-363; 3-Mercaptopropionyl-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond); deamino-Cys-Glu-His-D-2Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asn-OH (Disulfide bridge: Cys1-Cys8); deamino-cysteinyl-L-alpha-glutamyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-asparagine (1->8)-disulfide; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-; [Deamino-Cys11,β-(2-Naphthyl)-D-Ala14,Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22. Grades: ≥95% by HPLC. CAS No. 436083-30-6. Molecular formula: C69H91N19O16S2. Mole weight: 1506.72. | |
| JLK 6 | JLK 6, under the IUPAC name 7-amino-4-chloro-3-methoxyisochromen-1-one, an inhibitor of γ-secretase (IC50 = between 10 μM-1 mM) that belongs to the class of isocoumarin analogs, prevents recovery of Aβ40 and Aβ42 (IC50 < 100 μM) in HEK293 cells overexpressing wild-type and Swedish-mutant β-amyloid precursor protein (APP). Synonyms: JCP-251; JCP 251; JCP251 7-amino-4-chloro-3-methoxyisochromen-1-one; 7-Amino-4-chloro-3-methoxyisocoumarin; jlk6; 62252-26-0; JLK 6; 7-Amino-4-chloro-3-methoxy-isocoumarin; gamma-Secretase Inhibitor XI; 7-amino-4-chloro-3-methoxyisochromen-1-one; AC1L1GQZ; AC1Q3FXG; JLK-6; CHEMBL149518; SCHEMBL3056620; CTK2F1888; AMDGKLWVCUXONP-UHFFFAOYSA-N; HMS3269N03; ZINC2523036; AR-1H3136; ZINC02523036; 7-amino-3-methoxy-4-chloroisocoumarin; AKOS024457236; NCGC00167827-01; AK396360; HE005374; HE366264; TX-017351; 7-Amino-4-chloro-3-methoxy-isochromen-1-one; 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one; 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-; BRD-K22010301-001-01-2; JLK 6|7-Amino-4-chloro-3-methoxy-1H-2-benzopyran; JLK 6; 7-AMINO-4-CHLORO-3-METHOXY-1H-2-BENZOPYRAN. CAS No. 62252-26-0. Molecular formula: C10H8ClNO3. Mole weight: 225.63. | |
| JNJ10181457 | JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 receptors respectively. It increases acetylcholine and extracellular norepinephrine levels in rat frontal cortex, but it does not stimulate dopamine release. It normalizes acetylcholine neurotransmission and shows efficacy in translational rat models of cognition. Uses: Jnj10181457 dihydrochloride normalizes acetylcholine neurotransmission. Synonyms: JNJ-10181457; JNJ10181457; JNJ 10181457; JNJ-10181457 dihydrochloride;4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine dihydrochloride. Grades: >98 %. CAS No. 544707-19-9. Molecular formula: C20H28N2O. Mole weight: 312.4. | |
| JNJ 10181457 dihydrochloride | The hydrochloride salt form of JNJ 10181457, which has been found to be a histamine H3 receptor inhibitor and could be a brain penetrant. Synonyms: JNJ 10181457 dihydrochloride; JNJ10181457 dihydrochloride; JNJ-10181457 dihydrochloride; 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 544707-20-2. Molecular formula: C20H28N2O.2HCl. Mole weight: 385.37. | |
| JNJ-10191584 | JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and analgesic effects in animal studies of acute inflammation. No development was reported for the treatment of Allergic rhinitis, Atopic dermatitis, Pruritus and Respiratory tract disorders. Uses: Allergic rhinitis; atopic dermatitis; pruritus; respiratory tract disorders. Synonyms: JNJ-10191584; JNJ10191584; JNJ 10191584; VUF-6002; VUF 6002; VUF6002; (5-Chloro-1H-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone;869497-75-6(maleate). Grades: 98%. CAS No. 73903-17-0. Molecular formula: C13H15ClN4O. Mole weight: 278.74. | |
| JNJ 10191584 maleate | The maleate salt form of JNJ 10191584, which has been found to be a selective histamine H4 receptor silent antagonist and could restrain mast cell and eosinophil chemotaxis in vitro. Synonyms: VUF6002; VUF 6002; VUF-6002; JNJ-10191584 maleate; JNJ 10191584 maleate; JNJ10191584 maleate; 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate. Grades: ≥99% by HPLC. CAS No. 869497-75-6. Molecular formula: C13H15ClN4O.C4H4O4. Mole weight: 394.81. | |
| JNJ10229570 | JNJ10229570 is a novel MC1R and MC5R antagonist. It was used to treat primary human sebaceous cells. It might have a potential for the treatment of acne and other sebaceous gland pathologies. It was developed by Johnson & Johnson. It was in phase II clinical trials, but has been terminated. Uses: Jnj10229570 was used to treat primary human sebaceous cells. it might have a potential for the treatment of acne and other sebaceous gland pathologies. Synonyms: JNJ-10229570; JNJ10229570; JNJ 10229570; UNII-N9IX402L35;2,3-Bis(2-methoxyphenyl)-N-phenyl-1,2,4-thiadiazol-5-imine;Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-. Grades: 98%. CAS No. 524923-88-4. Molecular formula: C22H19N3O2S. Mole weight: 389.47. | |
| JNJ-10258859 | JNJ-10258859 is a novel, potent, and selective phosphodiesterase type 5 inhibitor 5 with a K(I) of 0.23 nM and displayed excellent selectivity versus phosphodiesterase types 1-4. Uses: Phosphodiesterase type 5 inhibitor. Synonyms: JNJ-10258859; JNJ 10258859; JNJ10258859; UNII-4NPX9224XR. (3R)-3-(2,3-dihydro-1-benzofuran-5-yl)-2-[5-(4-methoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one. Grades: ≥98%. CAS No. 374927-03-4. Molecular formula: C30H24N4O3. Mole weight: 488.54. | |
| JNJ10311795 | JNJ10311795 is a dual inhibitor of Chymase and leukocyte Proteases Cathepsin G. It has inflammation therapeutic efficacy in animals models. Uses: Jnj10311795 has inflammation therapeutic efficacy. Synonyms: JNJ-10311795; JNJ 10311795; JNJ10311795. [2-[3-[Methyl-[1-(naphthalene-2-carbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid;Phosphonic acid, (2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naph. Grades: 98%. CAS No. 518062-14-1. Molecular formula: C40H35N2O6P. Mole weight: 670.70. | |
| JNJ-10397049 | JNJ-10397049 is a selective orexin-2 receptor (OX2) antagonist. pIC50 is 7.4 for chimeric OX2 receptors/ pKB values are 5.9 for OX1 and 8.5 for OX2 receptors respectively. JNJ-10397049 exhibits no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. It achieves high level of OX2 receptor occupancy in the rat brain. Synonyms: JNJ-10397049; JNJ 10397049; JNJ10397049; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-(1,3)dioxan-5-yl)urea. Grades: 98%. CAS No. 708275-58-5. Molecular formula: C19H20Br2N2O3. Mole weight: 484.19. | |
| JNJ-1250132 | JNJ-1250132, a new steroidal progestin antagonist, inhibits binding of the receptor to DNA in vitro. JNJ-1250132 induces a receptor conformation more similar to that induced by mifepristone, which promotes receptor binding to DNA. Synonyms: [(8S,11R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-11-(4-piperidin-1-ylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; JNJ-1250132; JNJ 1250132; JNJ1250132. Grades: >98%. CAS No. 240805-96-3. Molecular formula: C33H41NO4. Mole weight: 515.68. | |
| JNJ 16259685 | JNJ 16259685, a pyrano-quinolin derivative, has been found to be a metabotropic glutamate receptor-1 antagonist. Synonyms: JNJ16259685; JNJ 16259685; JNJ-16259685; (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone. Grades: ≥98% by HPLC. CAS No. 409345-29-5. Molecular formula: C20H23NO3. Mole weight: 325.41. | |
| JNJ 17029259 | JNJ 17029259 is an selective, nanomolar inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2), blocks VEGF-stimulated mitogen-activated protein kinase signaling, proliferation/migration. Uses: Vascular endothelial growth factor receptor-2 (vegf-2) kinase inhibitor. Synonyms: JNJ-17029259; JNJ 17029259; JNJ17029259. 4-[4-(2-aminopropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethyl)anilino]pyrimidine-5-carbonitrile. Grades: ≥98%. CAS No. 314267-57-7. Molecular formula: C26H30N6O. Mole weight: 442.56. | |
| JNJ17156516 | JNJ17156516 is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516; JNJ 17156516; JNJ17156516; (S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid. Grades: 98%. CAS No. 649551-06-4. Molecular formula: C26H22Cl2N2O3. Mole weight: 481.37. | |
| JNJ17156516 sodium | JNJ17156516 sodium is the sodium salt form of JNJ17156516, which is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516 sodium; JNJ 17156516 sodium; JNJ17156516 sodium; 1H-Pyrazole-3-propanoic acid, 5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-alpha-(3-methylphenyl)-, sodium salt (1:1), (alphaS)-;(S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid sodium s. Grades: 98%. CAS No. 648861-58-9. Molecular formula: C26H21Cl2N2NaO3. Mole weight: 503.35. | |
| JNJ-17203212 | JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human TRPV1 and rat TRPV1. It could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. It inhibits capsaicin- and H+-induced channel activation, which pIC50 values are 6.32 and 7.23 respectively. It exhibits antitussive and analgesic activity in vivo. Uses: Jnj-17203212 could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. it inhibits capsaicin- and h+-induced channel activation. it exhibits antitussive and analgesic activity in vivo. Synonyms: JNJ-17203212; JNJ 17203212; JNJ17203212. 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide;1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-;N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine. Grades: >99 %. CAS No. 821768-06-3. Molecular formula: C17H15F6N5O. Mole weight: 419.32. | |
| JNJ-19567470 | JNJ-19567470 is a selective Corticotropin releasing factor (CRF) receptor antagonist. It is a novel target for developing anti-panic drugs. JNJ-19567470 is as effective as benzodiazepines in treatment of a panic attack which prevents sodium lactate-induced acute panic-like responses. In Oct 2009, preclinical development in Anxiety disorders was ongoing in Japan. Uses: Anxiety disorders. Synonyms: JNJ-19567470; JNJ19567470; JNJ 19567470; TAI-041; TAI 041; TAI041; R-317573;1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-4-Piperidinemethanol. Grades: 98%. CAS No. 724471-26-5. Molecular formula: C22H27BrN4O. Mole weight: 443.38. | |
| JNJ 20788560 | JNJ-20788560 is a delta opioid agonist analgesics. No recent reports of development identified for preclinical development in Inflammatory-pain in USA. Uses: Inflammatory pain; pain. Synonyms: JNJ-20788560; JNJ 20788560; JNJ20788560; 9-(8-Azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide. Grades: 98%. CAS No. 825649-28-3. Molecular formula: C25H28N2O2. Mole weight: 388.51. | |
| JNJ26076713 | JNJ26076713 is an orally active alpha V integrin antagonist. It may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Uses: Jnj26076713 may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Synonyms: JNJ-26076713; JNJ26076713; JNJ 26076713;3-Quinolinepropanoic acid, 1,2,3,4-tetrahydro-beta-((1-(1-oxo-3-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)propyl)-4-piperidinyl)methyl)-, (betaS,3S)-;(3S)-4-[1-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoyl]piperidin-4-yl]-3-[(3S)-1,2. Grades: 98%. CAS No. 669076-03-3. Molecular formula: C29H38N4O3. Mole weight: 490.65. | |
| JNJ-26146900 | JNJ-26146900 is a selective, nonsteroidal androgen receptor modulator with tissue-selective activity in rats. It can bind to the rat AR with a Ki of 400nM and act as a pure androgen antagonist in an in vitro cell-based assay. But no development was reported for the treatment of Bone disorders and Cancer till now. Uses: Bone disorders; cancer. Synonyms: JNJ-26146900; JNJ 26146900; JNJ26146900. (-)(R)-2-(2-Ethylsulfonyl-1-hydroxy-1-methylethyl)-6-trifluoromethyl-1H-indole-5-carbonitrile. Grades: 98%. CAS No. 868691-50-3. Molecular formula: C15H15F3N2O3S. Mole weight: 360.35. | |
| JNJ 26481585 dihydrochloride | JNJ 26481585 dihydrochloride is a potent and second-generation pan-HDAC inhibitor (IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with antineoplastic activity. JNJ-26481585 inhibiting HDAC leads to continuous acetylation of histone H3, activation of the caspase cascade, upregulation of p21, and tumor cell apoptosis. Uses: Antitumor agent. Synonyms: JNJ 26481585 dihydrochloride; JNJ26481585 dihydrochloride; JNJ-26481585 dihydrochloride; Quisinostat HCl; N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride. Grades: 99%. CAS No. 875320-31-3. Molecular formula: C21H26N6O2.2HCl. Mole weight: 467.39. | |
| JNJ-26489112 | JNJ-26489112 is a CNS active agent that can be used to treat depression and photosensitive epilepsy. Synonyms: JNJ26489112; JNJ 26489112. CAS No. 871824-55-4. Molecular formula: C9H11ClN2O4S. Mole weight: 278.71. | |
| JNJ 27141491 | JNJ 27141491 is a potent and selective human CCR2 antagonist. Synonyms: JNJ27141491; JNJ 27141491; JNJ-27141491; 4,4-difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide; maraviroc; Pfizer Brand of maraviroc; Selzentry; UK-427,857; UK-427857. CAS No. 871313-59-6. Molecular formula: C17H15F2N3O3S. Mole weight: 379.38. | |
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