BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Imiglitazar | Imiglitazar, also known as TAK-559,with hypoglycemic activity it is a non-thiazolidinedione dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist. Synonyms: (4E)-4-[[4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl]methoxyimino]-4-phenylbutanoic acid; Imiglitazar; TAK 559; TAK-559; TAK559. Grades: >98%. CAS No. 250601-04-8. Molecular formula: C28H26N2O5. Mole weight: 470.52. |  |
| Imiloxan hydrochloride | Imiloxan hydrochloride is the hydrochloride salt of imiloxan, which is a moderately potent and highly selective α2-adrenoceptor antagonist. It shows no affinity for α1-adrenoceptor. Synonyms: 1H-Imidazole, 2-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl-, hydrochloride (1:1); 1H-Imidazole, 2-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl-, monohydrochloride; Imiloxan monohydrochloride; 2-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl-1H-imidazole monohydrochloride; 1-Ethyl-2-(benzodioxan-2-yl)methylimidazole monohydrochloride; RS 21361 monohydrochloride; 2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-ethyl-1H-imidazole monohydrochloride. Grades: ≥98% by HPLC. CAS No. 81167-22-8. Molecular formula: C14H17N2O2Cl. Mole weight: 280.75. | |
| Imiquimod maleate | Imiquimod maleate is an immune response modifier. It acts as a toll-like receptor 7 agonist. It is commonly used topically to treat warts on the skin of the genital and anal areas. It is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. It can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system when applied to skin. Uses: Imiquimod maleat is commonly used topically to treat warts on the skin of the genital and anal areas. it is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. Synonyms: R 837 maleate; R837 maleate; R-837 maleate. Grades: >98%. CAS No. 896106-16-4. Molecular formula: C18H20N4O4. Mole weight: 356.38. | |
| Immepip dihydrobromide | Immepip dihydrobromide is the dihydrobromide salt of immepip, which is a potent and selective nonchiral histamine H3 receptor agonist with Ki values of 0.4 nM. It is selective equipotent to (R)-α-methylhistamine and is effective in vitro and in vivo. It is devoid of side activities elicited at H1, α2 receptors and 5-HT3 receptors. Synonyms: 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide. CAS No. 164391-47-3. Molecular formula: C9H17N3Br2. Mole weight: 327.06. | |
| Immethridine dihydrobromide | Immethridine dihydrobromide is the dihydrobromide salt of immethridine, which is a highly selective, potent and novel histamine H3 receptor agonist with pEC50 value of 9.74. It shows 300-fold selectivity over the histamine H4 receptor and does not bind to H1 or H2 receptors at concentrations up to 10 μM. Synonyms: 4-(1H-Imidazol-4-ylmethyl)pyridine dihydrobromide. Grades: ≥99% by HPLC. CAS No. 699020-93-4. Molecular formula: C9H11N3Br2. Mole weight: 321.01. | |
| Impentamine dihydrobromide | Impentamine dihydrobromide is the dihydrobromide salt of impentamine, which is a highly selective and the most potent histamine H3 antagonist with pA2 value of 8.4. It also acts as a partial agonist in SK-N-MC cells expressing human H3 receptors. It shows > 30000-fold selectivity over histamine H1 and H2 receptors. Synonyms: 1H-Imidazole-5-pentanamine, hydrobromide (1:2); 1H-Imidazole-4-pentanamine, dihydrobromide. Grades: ≥95%. CAS No. 149629-70-9. Molecular formula: C8H17N3Br2. Mole weight: 315.05. | |
| Impurity C of Alfacalcidol | Cas No. 82266-85-1. | |
| IN01001 | INO1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. It inhibits PARP and results in inhibition of tumor cell DNA repair mechanisms. It has tumor cell resistance and may be used to chemotherapy and radiation therapy. Uses: Ino1001 has tumor cell resistance and may be used to chemotherapy and radiation therapy. Synonyms: IN01001; IN 01001; IN-01001; N-(3-morpholin-4-ylpropyl)-5-oxo-6,11-dihydroindeno[1,2-c]isoquinoline-9-sulfonamide;INO-1001;5H-Indeno[1,2-c]isoquinoline-9-sulfonaMide, 6,11-dihydro-N-[3-(4-Morpholinyl)propyl]-5-oxo. Grades: 98%. CAS No. 501364-82-5. Molecular formula: C23H25N3O4S. Mole weight: 439.53. | |
| IN-1130 | IN-1130 is a selective ALK5 inhibitor with >100 fold selectivity over p38α and a panel of 26 other serine/threonine and tyrosine kinases. It also inhibit phosphorylation of Smad-2 with an IC50 value of 36 nM. IN-1130 is a suppressor of fibrogenic process of unilateral ureteral obstruction in rats underscoring the potential clinical benefits in the treatment of renal fibrosis. It can also inhibit cancer metastasis in MMTV/c-Neu breast cancer mice, and enhance CTL response in cancer mice. Preclinical clinical research for Cancer and Fibrosis is on-going. Uses: Cancer; connective tissue disorders; fibrosis. Synonyms: IN-1130; IN1130; IN 1130. 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl) methyl)benzamide. Grades: 98%. CAS No. 868612-83-3. Molecular formula: C25H20N6O. Mole weight: 420.47. | |
| Inauhzin | Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice. Synonyms: Inauhzin. Grades: 0.98. CAS No. 309271-94-1. Molecular formula: C25H19N5OS2. Mole weight: 469.58. | |
| INCA-6 | INCA-6, a cell-permeable quinone compound, is a selective and potent inhibitor of Calcineurin Nuclear Factor of Activated T cells (NFAT) signaling. It binds to calcineurin with high affinity and does not affect calcineurin activity or its downstream signaling. It blocks its dephosphorylation and nuclear import, thus interferes with downstream targets of NFAT including induction of cytokine mRNAs. Synonyms: INCA-6; INCA 6; INCA6; 9,10-Dihydro-9,10-o-benzenoanthracene-1,4-dione; 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione; 1,4-Triptycenoquinone; 12,15-Dihydro-12,15-dioxotriptycene; NSC 25996; Triptycene-1,4-quinone. Grades: ≥98% by HPLC. CAS No. 3519-82-2. Molecular formula: C20H12O2. Mole weight: 284.31. | |
| INCB054329 | INCB054329 is a novel bromodomain and extraterminal domain (BET) inhibitor. It induces vulnerabilities in myeloma cells by inhibition of BET protein. Uses: Antineoplastic agents. Synonyms: INCB-054329; INCB-54329; 7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one. CAS No. 1628607-64-6. Molecular formula: C19H16N4O3. Mole weight: 348.36. | |
| INCB057643 | INCB057643 is a bromodomain and extraterminal domain (BET) inhibitor. It binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. Synonyms: INCB-057643; 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one. CAS No. 1820889-23-3. Molecular formula: C20H21N3O5S. Mole weight: 415.46. | |
| INCB 3284 | INCB 3284 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM. Synonyms: N-(2-(((R)-1-((1r,4R)-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide dimethanesulfonate; INCB3284; INCB 3284; INCB-3284; INCB3284 mesylate; INCB3284 dimesylate. CAS No. 887401-92-5. Molecular formula: C26H31F3N4O4. Mole weight: 520.54. | |
| INCB 3284 dimesylate | INCB 3284 dimesylate is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM. Synonyms: INCB 3284 dimesylate; INCB3284 dimesylate; INCB-3284 dimesylate; N-[2-[[(3R)-1-[trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide, dimethanesulfonate. CAS No. 887401-93-6. Molecular formula: C26H31F3N4O4.2CH4O3S. Mole weight: 712.76. | |
| INCB-9471 Dihydrochloride | INCB-9471 HCl is an allosteric non-competitive small molecule antagonist of C-C chemokine receptor 5, which has strong inhibitory activity on monocyte migration and HIV-1 infection. Synonyms: Methanone,(4,6-Dimethyl-5-Pyrimidinyl)[4-[(3S)-4-[(1R,2R)-2-Ethoxy-2,3-Dihydro-5-(Trifluoromethyl)-1H-Inden-1-Yl]-3-Methyl-1-Piperazinyl]-4-Methyl-1-Piperidinyl]-,Hydrochloride (1:2). Grades: 98%. CAS No. 869725-27-9. Molecular formula: C30H42Cl2F3N5O2. Mole weight: 632.6. | |
| Incensole acetate | Incensole acetate, a Boswellia Resin constituent, is a novel TRPV3 agonist and NF-κB inhibitor. Incensole acetate exhibits anxiolytic and antidepressive properties in wild-type (WT) mice with concomitant changes in c-Fos activation in the brain. Synonyms: GTPL4220; 1,5,9-trimethyl-12-(propan-2-yl)-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl acetate. CAS No. 34701-53-6. Molecular formula: C22H36O3. Mole weight: 348.52. | |
| Indantadol | Indantadol is a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. Synonyms: 2-(2,3-dihydro-1H-inden-2-ylamino)acetamide; CHF-3381; CNP-3381; GT-3381; V-3381; CMP-3381; CHF 3381; CNP 3381; GT 3381; V 3381; CMP 3381; CHF3381; CNP3381; GT3381; V3381; CMP3381; N-(2-indanyl)glycinamide; N-(2-indanyl)glycinamide hydrochloride. Grades: >98%. CAS No. 202844-10-8. Molecular formula: C11H14N2O. Mole weight: 190.246. | |
| Indatraline hydrochloride | Indatraline hydrochloride is the hydrobromide salt of indatraline, which is a potent monoamine uptake inhibitor. It inhibits the synaptosomal uptake of noradrenaline, 3,4-dihydroxyphenylethylamine and 5-hydroxytryptamine with Ki values of 5.8, 1.7 and 0.42 nM respectively. It is centrally active following systemic administration in vivo. Synonyms: 1H-Inden-1-amine, 3-(3,4-dichlorophenyl)-2,3-dihydro-N-methyl-, hydrochloride (1:1), (1R,3S)-rel-; 1H-Inden-1-amine, 3-(3,4-dichlorophenyl)-2,3-dihydro-N-methyl-, monohydrochloride, (1R,3S)-rel-; 1H-Inden-1-amine, 3-(3,4-dichlorophenyl)-2,3-dihydro-N-methyl-, hydrochloride, trans-(±)-; 1H-Inden-1-amine, 3-(3,4-dichlorophenyl)-2,3-dihydro-N-methyl-, hydrochloride, trans-; Indatraline monohydrochloride; Lu 19-005. Grades: ≥99% by HPLC. CAS No. 96850-13-4. Molecular formula: C16H16Cl3N. Mole weight: 328.67. | |
| Indecainide | Indecainide is a Sodium channel antagonists originated by Eli Lilly. Treatment for Arrhythmias and Ventricular arrhythmias was discontinued. Uses: Arrhythmias; ventricular arrhythmias. Synonyms: Ricainid, Indecainida, Indecainidum, Decabid, Ricainide;9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide. Grades: 98%. CAS No. 74517-78-5. Molecular formula: C20H24N2O. Mole weight: 308.42. | |
| Indeglitazar | Indeglitazar is a peroxisome proliferator-activated receptor (PPAR) pan-agonist. Phase II clinical trials for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: PLX-204; PLX204; PLX 204; PPM-204; PPM204; PPM 204; Indeglitazar; 3-(5-Methoxy-1-((4-methoxyphenyl)sulfonyl)-1H-indol-3-yl)propanoic acid. Grades: 98%. CAS No. 835619-41-5. Molecular formula: C19H19NO6S. Mole weight: 389.43. | |
| Indibulin | Indibulin, also called D 24851, estabilizes tubulin polymerization (IC50 = 0.3 μM) and induces tumor cell cycle arrest and apoptosis. In vitro: blocking cell cycle progression at metaphase; In vivo: induce complete tumor remission in the Yoshida AH13 rat sarcoma model. Synonyms: 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide; D 24851; D-24851; indibulin; N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide; N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide. CAS No. 204205-90-3. Molecular formula: C22H16ClN3O2. Mole weight: 389.83. | |
| Indimilast | Indimilast is a phosphodiesterase IV inhibitor. It modulates lung inflammation and cause bronchodilation by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. It is potential useful in chronic obstructive pulmonary disease(COPD). Uses: Indimilast is potential useful in chronic obstructive pulmonary disease(copd). Synonyms: N-[4-[1-[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]-6-fluoro-2,4-dioxopyrido[2,3-d]pyrimidin-3-yl]cyclohexyl]-2-methyl-1,3-thiazole-4-carboxamide;N-{cis-4-[1-(4'-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}[1,1'-biphenyl]-3-yl)-6-fluoro-2,4-dioxo-1,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}-2-methyl-1,3-thiazole-4-carboxamide. Grades: >98 %. CAS No. 1038825-85-2. Molecular formula: C37H40FN7O3S. Mole weight: 681.83. | |
| Indinavir | Indinavir is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Indinavir is used as an antiviral. Uses: Hiv protease inhibitors. Synonyms: Crixivan; MK-639; L-735524; MK639; L735524; MK 639; L 735524. Grades: >98%. CAS No. 150378-17-9. Molecular formula: C36H47N5O4. Mole weight: 613.79. | |
| Indinavir sulfate | Indinavir is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV infection and AIDS. It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. However, indinavir demonstrates up to a 50-fold loss in potency against the HIV-1 protease drug-resistant mutations PRL24I, PRI50V, and PRG73S (Kis = 1.4, 27, and 0.55 nM). Uses: Hiv protease inhibitors. Synonyms: Crixivan sulfate; MK-639 sulfate; L-735524 sulfate; MK639 sulfate; L735524 sulfate; MK 639 sulfate; L 735524 sulfate. Grades: >98%. CAS No. 157810-81-6. Molecular formula: C36H49N5O8S. Mole weight: 711.87. | |
| Indiplon | Indiplon acts as a high-affinity positive and orally active allosteric modulator of the GABAA receptor (Ki=1.2 nM in rat frontal cortex and Ki=1.7 nM and in cerebellum). Uses: Sedative, hypnotic. Synonyms: NBI-34060; NBI34060; NBI 34060; CL285,489; CL-285,489; CL 285,489; CL-285489; CL 285489; CL285489; Indiplon; INDIPLON;N-Methyl-N-[3-[3-(thien-2-ylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide;Acetamide, N-methyl-N-(3-(3-(2-thienylcarbonyl)pyrazolo(1,5-A)pyrimidin-7-yl)phenyl)-;NBI 34060;Unii-8bt63da42e. Grades: >99 %. CAS No. 325715-02-4. Molecular formula: C20H16N4O2S. Mole weight: 376.43. | |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime, a chemical derivative of indirubin, is an inhibitor of GSK-3β with dual affinity for CDK1/5 receptor. It significantly inhibited the proliferation and induced apoptosis in all of the RCC cell lines. IC50: GSK-3β= 22nM; CDK1/5= 180/1. Synonyms: 3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one INDIRUBIN-3'-MONOXIME indirubin-3'-oxime 160807-49-8 indirubin-3-oxime Indirubin-3monoxime indirubin-3'-monooxime 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one Indirubin-3'-monoxime CHEMBL126077 CHEBI:43. CAS No. 160807-49-8. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| (-)-Indolactam V | (-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC), which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. It is weak tumor promoter. It binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 μM, respectively. It induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of PKC signaling at 1 μM. It may be used as an effective diabetes therapy. It may share an RA-dependent signaling pathway, allowing ultimately to streamline the process of efficient pancreatic endoderm derivation. It was predicted to be a biosynthetic intermediate and was confirmed via in vitro prenylation by LtxC due to the structural relatedness of the lyngbyatoxins and teleocidin. It induces differentiation of a substantial number of Pdx1-expressing cells from human ESCs. Uses: (-)-indolactam v induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of pkc signaling. it may be used as an effective diabetes therapy. Synonyms: (2S-(2R*,5R*))-ethyl)-1-methyl-2-(1-methylethyl);3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym;(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one;3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-;Indolactam V. Grades: >98%. CAS No. 90365-57-4. Molecular formula: C17H23N3O2. Mole weight: 301.38. | |
| Indolapril hydrochloride | Indolapril hydrochloride is a nonsulfhydryl ACE (angiotensin converting enzyme) inhibitor. It is an antihypertensive agent. Uses: Antihypertensive agent. Synonyms: (2S,3aS,7aS)-1-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylic Acid Hydrochloride; (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic Acid Monohydrochloride; [2S-[1[R*(R*)], 2α, 3aβ, 7aβ]]-1-[2-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic Acid Monohydrochloride; CI 907; CI907; CI-907; Indolapril Hydrochloride; REV 6000A(SS). Grades: 98%. CAS No. 80828-32-6. Molecular formula: C24H35ClN2O5. Mole weight: 467.00. | |
| Indole-5-carboxamide | SD-169 is an ATP-competitive and orally bioactive inhibitor of p38α MAP kinase (IC50 = 3.2 nM) with 38 fold selectivity over p38β MAP kinase (IC50 = 122 nM). SD-169 decreases p38 MAP kinase expression in T cells, lowers blood glucose and reduces the risk of diabetes. It has no inhibitory effect against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2. Synonyms: SD-169; SD169; 5-(Aminocarbonyl)-1H-indole; 5-Carbamoylindole. Grades: 99 %. CAS No. 1670-87-7. Molecular formula: C9H8N2O. Mole weight: 160.17. | |
| Indometacin sodium | Indomethacin sodium is the sodium salt of indomethacin, a non-selective, reversible, and competitive inhibitor of COX-1 and -2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects. Synonyms: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid sodium salt. Grades: ≥98% (HPLC). CAS No. 74252-25-8. Molecular formula: C19H21ClNNaO7. Mole weight: 433.82. | |
| Indoprofen | Indoprofen, a non-steroidal anti-inflammatory drug, is a cyclooxygenase inhibitor and used for the treatment of pain and inflammation and spinal muscular atrophies. Uses: A non-steroidal anti-inflammatory agent. Synonyms: Indoprofen; Flosint; Isindone; K 4277; K-4277; K4277; Reumofene; 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid;INDOPROFEN;ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID; 1-oxo-2- (p- ( (alpha-methyl) carboxymethyl) phenyl) isoindoline; 2- (4- (1-carboxyethyl) phenyl) -1-isoindolinone; 2- (p- (1-oxo-2-isoindolinyl) pheny. CAS No. 31842-01-0. Molecular formula: C17H15NO3. Mole weight: 281.31. | |
| Ingenol 3-Hexanoate | Ingenol 3-Hexanoate, an ingenol-derived compound, was more potent in reactivating latent HIV than other known activators such as SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. Synonyms: Hexanoic acid, (1aR, ?2S, ?5R, ?5aS, ?6S, ?8aS, ?9R, ?10aR) ?-1a, ?2, ?5, ?5a, ?6, ?9, ?10, ?10a-octahydro-5, ?5a-dihydroxy-4- (hydroxymethyl) ?-1, ?1, ?7, ?9-tetramethyl-11-oxo-1H-2, ?8a-methanocyclopenta [a]?cyclopropa [e]?cyclodecen-6-yl ester; Hexanoic acid, 1a, 2, 5, 5a, 6, 9, 10, 10a-octahydro-5, 5a-dihydroxy-4- (hydroxymethyl) -1, 1, 7, 9-tetramethyl-11-oxo-1H-2, 8a-methanocyclopenta [a]cyclopropa [e]cyclodecen-6-yl ester, [1aR-(1aα, 2β, 5β, 5aβ, 6β, 8aα, 9α, 10aα)]- (9CI); 1H-2, 8a-Methanocyclopenta [a]cyclopropa [e]cyclodecene, hexanoic acid deriv.; 3-Hexanoylingenol. CAS No. 83036-61-7. Molecular formula: C26H38O6. Mole weight: 446.58. | |
| Ingliforib | Ingliforib, with antihyperglycemic and cardioprotective properties, inhibits glycogen phosphorylase. Synonyms: Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296; 5-chloro-N-[(2S,3R)-4-[(3S,4R)-3,4-dihydroxypyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1H-indole-2-carboxamide; 5-Chloro-N-((1S,2R)-3-((3R,4S)-3,4-dihydroxy-1-pyrrolidinyl))-2-hydroxy-3-oxo-1-(phenylmethyl)propyl-1H-indole-2-carboxamide. Grades: >98%. CAS No. 186392-65-4. Molecular formula: C23H24ClN3O5. Mole weight: 457.91. | |
| Iniparib | BSI-201 is a small-molecule prodrug inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) with potential chemosensitizing, radiosensitizing and antineoplastic activities. In vivo, PARP-1 inhibitor BSI-201 is converted to the active drug, which selectively binds to PARP-1 and inhibits PARP-1- mediated DNA repair. Consequently, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. In addition, PARP-1 inhibitor BSI-201 may exhibit direct antineoplastic activity against cancers defective in DNA repair. PARP-1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: BSI-201; BSI201; BSI 201; NSC746045; NSC-746045; NSC 746045; ND-71677; NIBA; INO-2BA; SAR-240550; IND-71677. IND 71677; IND71677; Iniparib. Grades: 99.82%. CAS No. 160003-66-7. Molecular formula: C7H5IN2O3. Mole weight: 292.032. | |
| Inolitazone | Inolitazone is an orally bioavailable PAPR-gamma inhibitor with potential antineoplastic activity. Inolitazone binds to and activates peroxisome proliferation-activated receptor gamma (PPAR-gamma), which may result in the induction of tumor cell differentiation and apoptosis, and so a reduction in tumor cell proliferation. PPAR-gamma is a nuclear hormone receptor and ligand-activated transcription factor controlling gene expression involved in such cellular processes as differentiation, apoptosis, cell-cycle control, carcinogenesis, and inflammation. Synonyms: CS-7017, CS7017; CS 7017; RS5444; RS-5444; RS 5444; Efatutazone; PPAR-gamma agonist CS-7017, CS-7017, RS5444. Efatutazone. CAS No. 223132-37-4. Molecular formula: C27H26N4O4S. Mole weight: 502.58. | |
| Inolitazone dihydrochloride | In vitro, the IC50 for growth inhibition is approximately 0.8 nM while anaplastic thyroid carcinoma (ATC) tumor growth was inhibited three- to fourfold in nude mice. siRNA against PPARgamma and a pharmacological antagonist demonstrated that functional PPARgamma was required for growth inhibitory activity of RS5444. RS5444 upregulated the cell cycle kinase inhibitor, p21WAF1/CIP1. RS5444inhibited culture growth and caused irreversible G1 arrest, but did not induce apoptosis. In addition, RS5444 caused dramatic changes in cellular morphology which were associated with increased motility and diminished cellular adherence, but no increase in the ability of such cells to digest and invade Matrigel. Treatment with RS5444 leads to the up-regulation of RhoB and subsequent activation of p21, and that silencing of RhoB by RNAi blocks the ability of RS5444 to induce p21 and to inhibit ATC cells proliferation. The median peak efatutazone blood level was 8.6 ng/mL for 0.15-mg dosing vs 22.0 ng/mL for 0.3-mg twice daily dosing. Although efatutazone treatment did not reduce percentage of mice developing invasive cancer, it significantly reduced prevalence of noninvasive cancer and total number of cancers per mouse and increased prevalence of well-differentiated cancer subtypes not usually seen in this mouse model. Uses: Antineoplastic agents. Synonyms: Efatutazone; Efatutazone hydrochloride; CS 7017; CS-7017; CS7017 ;RS-5444; RS5444; UNII-76B44WEA8O. Grades: >98%. CAS No. 223132-38-5. Molecular formula: C27H28Cl2N4O4S. Mole weight: 575.51. | |
| Inotilone | Inotilone is a potent and selective COX-2 inhibitor with IC50 value of 0.03 μM. Study indicated that inotilone exhibited anti-inflammatory effects via inhibition of MMP-9, NF-κB, and MAPK. Synonyms: 2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone. Grades: ≥98%. CAS No. 906366-79-8. Molecular formula: C12H10O4. Mole weight: 218.2. | |
| inS3-54A18 | inS3-54A18 is a potent inhibitor of the DNA-binding domain (DBD) of STAT3, with anti-cancer properties. Synonyms: inS3-54-A18; inS3-54A18; inS3-54 A18; inS354-A18; inS354 A18; inS354A18; (3Z)-3-[(4-chlorophenyl)methylidene]-1-(4-hydroxyphenyl)-5-phenylpyrrol-2-one. CAS No. 328998-53-4. Molecular formula: C23H16ClNO2. Mole weight: 373.83. | |
| Insulin-like Growth Factor | Insulin-like Growth Factors are a type of proteins with similar sequence to insulin. They function to stimulate growth as well as also possess some ability to decrease blood glucose levels. Synonyms: IGF. | |
| Insulin Sudelidec | Insulin Sudelidec is a hypoglycemic agent. Synonyms: N6.B29-{4-[N2-(15-carboxypentadecanoyl)-L-lysin-N6-yl]-4-oxobutanoyl}-B30-des-L-threonine-insulin (human). CAS No. 2415174-82-0. Molecular formula: C279H420N66O82S6. Mole weight: 6203.20. | |
| INT 131 | INT 131 is a hypoglycemic agent, displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs. Uses: Selective ppargamma modulator, enhancing insulin sensitivity. Synonyms: AMG-131; AMG 131; AMG131; INT-131; NT-131; INT-131; T-0903131; T-1312,4-Dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide. Grades: ≥98%. CAS No. 315224-26-1. Molecular formula: C21H12Cl4N2O3S. Mole weight: 511.93. | |
| INT-767 | INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was just planed a Phase II trial for Hepatic fibrosis. IC50: 30 nM(EC50, FXR), 630 nM(EC50, TGR5). Uses: Int-767 has been found to be a inhibitor of fxr and tgf5 and could have probable effect against some liver and metabolic diseases. Synonyms: INT-767; INT 767; INT767; CS-5007; CS 5007; CS5007; HY-12434; HY 12434; HY12434; Sulfuric acid sodium 3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5beta-cholane-23-yl ester salt. Grades: 98%. CAS No. 1000403-03-1. Molecular formula: C25H43NaO6S. Mole weight: 494.66. | |
| Integrin Antagonists 27 | Integrin Antagonists 27, as s novel anticancer agent., is a small molecule integrin αvβ3 antagonist. Uses: Anticancer agent. Synonyms: MDK-4976; Integrin Antagonist 27; MDK4976; MDK 4976; 3-{2-[(Z)-(1-{2-[(4-Methylphenyl)amino]-2-oxoethyl}-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-pyrrol-1-yl}benzoic acid. Grades: ≥96%. CAS No. 593274-97-6. Molecular formula: C24H20N4O5. Mole weight: 444.44. | |
| Iodophenpropit dihydrobromide | Iodophenpropit dihydrobromide is a selective and high affinity histamine H3 antagonist (KD = 0.3 nM). Synonyms: Carbamimidothioic acid, [2-(4-iodophenyl)ethyl]-, 3-(1H-imidazol-4-yl)propyl ester, dihydrobromide; N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide; 3-(1H-imidazol-5-yl)propyl (4-iodophenethyl)carbamimidothioate dihydrobromide. Grades: ≥98% by HPLC. CAS No. 145196-87-8. Molecular formula: C15H19IN4S.2HBr. Mole weight: 576.13. | |
| IOWH032 | iOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. Synonyms: iOWH-032; IOWH032; IOWH 032. Grades: 0.99. CAS No. 1191252-49-9. Molecular formula: C22H15Br2N3O4. Mole weight: 545.187. | |
| IOX1 | IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases. Synonyms: IOX1; IOX-1; IOX 1. Grades: >98%. CAS No. 5852-78-8. Molecular formula: C10H7NO3. Mole weight: 189.17. | |
| IOX4 | IOX4 is a potent and selective triazole-based inhibitor of Hypoxia-Inducible Factor (HIF) with selectivity for Prolyl-Hydroxylase 2 (PHD2) (IC50 = 1.6 nM). IOX4 induces HIFα in cells and in wild-type mice with marked induction in the brain tissue, revealing that it is useful for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke. Synonyms: Tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate. Grades: ≥98%. CAS No. 1154097-71-8. Molecular formula: C15H16N6O3. Mole weight: 328.3. | |
| IPAG | IPAG is a potent NMDA receptor antagonist at σ sites. It was used as an old antipsychiatric. Synonyms: 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine. Grades: ≥98% by HPLC. CAS No. 193527-91-2. Molecular formula: C17H22IN3. Mole weight: 395.29. | |
| Ipatasertib HCl | Ipatasertib, also known as GDC-0068, is a highly selective pan-Akt inhibitor targeting Akt1/2/3 (IC50= 5 nM/18 nM/8 nM in cell-free assays) with 620-fold selectivity over PKA. Ipatasertib is advancing in clinical development including a Phase 3 trial in patients with prostate cancer and three Phase 2 trials in patients with breast cancer, gastric cancer and prostate cancer. Synonyms: (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one hydrochloride.; GDC0068; GDC-0068; GDC 0068; RG7440; RG-7440; RG 7440; Ipatasertib; Ipatasertib hydrochloride, Ipatasertib HCl. CAS No. 1489263-16-2. Molecular formula: C24H33Cl2N5O2. Mole weight: 494.46. | |
| Iperoxo iodide | Iperoxo is an extremely potent agonist of muscarinic acetylcholine receptors (mAChR). Synonyms: Iperoxo; 4-((4,5-Dihydroisoxazol-3-yl)oxy)-N,N,N-trimethylbut-2-yn-1-aminium iodide. Grades: ≥98%. CAS No. 247079-84-1. Molecular formula: C10H17N2O2·I. Mole weight: 324.16. | |
| IPI-3063 | IPI-3063 is a potent and selective phosphoinoside-3-kinase (PI3K) p110δ inhibitor. IPI-3063 was shown to inhibit mouse B cell proliferation, survival, and plasmablast differentiation, and also inhibit human B cell proliferation in vitro. Synonyms: 4-Amino-6-[1-[8-(1-methyl-6-oxopyridin-3-yl)-1-oxo-2-propan-2-ylisoquinolin-3-yl]ethylamino]pyrimidine-5-carbonitrile. CAS No. 1425043-73-7. Molecular formula: C25H25N7O2. Mole weight: 455.51. | |
| Ipidacrine | Ipidacrine is a reversible acetylcholinesterase (AChE) inhibitor for the treatment of cognitive disorders. Synonyms: Amiridine; 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-ylamine; 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine. CAS No. 62732-44-9. Molecular formula: C12H16N2. Mole weight: 188.274. | |
| Iproniazid phosphate | Iproniazid phosphate is a non-selective, irreversible inhibitor of monoamine oxidase (MAOI) that has potential to treat hypertension. Synonyms: phosphoric acid;N'-propan-2-ylpyridine-4-carbohydrazide Iproniazid phosphate 305-33-9 Iproniazide phosphate Marsilid phosphate Isoproniazid phosphate Iproniazid as phosphate N'-Isopropylisonicotinohydrazide phosphate Iproniazid dihydrogen phosphate Iproni. CAS No. 305-33-9. Molecular formula: C9H16N3O5P. Mole weight: 277.21. | |
| Ipsapirone | Ipsapirone is a selective partial agonist of the serotonin (5-HT) receptor 5-HT1A. Its Ki value is 10 nM in hippocampal membranes. It reduces 5-HT release in rat ventral hippocampus in vivo. It also inhibits passive avoidance behavior and foot shock-induced aggression in rats. It has anxiolytic effects in vivo. It has been used to treat borderline personality disorder and depression. Uses: Anti-anxiety agents. Synonyms: TVX Q 7821; 1,1-Dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2-benzothiazol-3-one; 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide. Grades: ≥99% by HPLC. CAS No. 95847-70-4. Molecular formula: C19H23N5O3S. Mole weight: 401.48. | |
| IPSU | IPSU is a selective, orally available and brain penetrant OX2 receptor antagonist (pKi = 7.85) with 6-fold selectivity over OX1 receptors. Synonyms: 2-(1H-indol-3-ylmethyl)-9-(4-methoxypyrimidin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one. CAS No. 1373765-19-5. Molecular formula: C23H27N5O2. Mole weight: 405.49. | |
| IQ 1S | IQ 1S is a c-Jun N-terminal kinase (JNK) inhibitor. It inhibits the production of nitric oxide in vitro and inhibits the release of nitric oxide upon metabolism by liver microsomes. It attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. It also inhibits the production of LPS-induced proinflammatory cytokine. It has anti-inflammatory and immunosuppressive effects. Synonyms: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt. Grades: ≥99% by HPLC. CAS No. 1421610-21-0. Molecular formula: C15H8N3NaO. Mole weight: 269.23. | |
| IQ-1S free acid | IQ-1S free acid is a potent, selective c-Jun N-Terminal Kinase inhibitor with a preference for JNK3 (IC50=390, 360 and 87 nM for JNK1, 2 and 3 respectively). In vivo IQ-1S free acid exhibits immunosuppressant property and it inhibits murine delayed-type h. Synonyms: 11-nitroso-10H-indeno[1,2-b]quinoxaline IQ-1S (free acid) CHEMBL3393601 11-(hydroxyimino)indeno[2,3-b]quinoxaline 11-nitroso-10H-indeno[1,2-b]quinoxaline. CAS No. 23146-22-7. Molecular formula: C15H9N3O. Mole weight: 247.25. | |
| IQ 3 | IQ 3 is a selective and specific c-Jun N-terminal kinase 3 (JNK3) inhibitor with Kd value of 66 nM. It inhibits TNF-α and IL-6 production in vitro and inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells. Synonyms: IQ3; IQ-3; IQ 3; 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime. Grades: ≥98% by HPLC. CAS No. 312538-03-7. Molecular formula: C20H11N3O3. Mole weight: 341.32. | |
| iralukast | Iralukast is a Leukotriene D4 receptor antagonist originated by Novartis as a a structural analogue of LTD4. It is applicated for the treatment of asthma and inflammatory effects of these leukotrienesand. Uses: Asthma. Synonyms: Cgp 45715A; Cgp-45715A; Cgp45715A;sodium;6-acetyl-3-[(5E,7E,10R)-9-(2-carboxy-4-oxochromen-7-yl)sulfanyl-10-hydroxy-10-[3-(trifluoromethyl)phenyl]deca-5,7-dienoxy]-2-propylphenolate. Grades: 98%. CAS No. 125617-94-9. Molecular formula: C38H36F3NaO8S. Mole weight: 732.74. | |
| Irdabisant | Irdabisant is a potent, selective histamine H3 receptor inverse agonist. It displayed potent antagonist and inverse agonist activities in [³?S]guanosine 5'-O-(γ-thio)triphosphate binding assays. It may also have therapeutic utility in treating schizophrenia or be used as adjunctive therapy to approved antipsychotics. Uses: Irdabisant may also have therapeutic utility in treating schizophrenia or be used as adjunctive therapy to approved antipsychotics. Synonyms: CEP-26401; CEP 26401; CEP26401; Irdabisant; 3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one;CEP-26401;CEP26401;(R)-6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)pyridazin-3(2H)-one. Grades: >98 %. CAS No. 1005402-19-6. Molecular formula: C18H23N3O2. Mole weight: 313.40. | |
| IRL-1038 | IRL-1038 is an ETB endothelin receptor antagonist. It inhibits ETB receptor-mediated contraction of tracheal smooth muscle and guinea-pig ileal without any significant agonist activity. But it does not affect the ETA receptor-mediated contraction of rat aortic smooth muscle. Synonyms: Cys(11)-Cys(15)-endothelin-1 (11-21); Irl-1038; 144602-02-8; Irl 1038; Endothelin-1 (11-21), cys(11)-cys(15)-; Endothelin-1(11-21), cysteinyl(11)-cysteine(15)-; Endothelin 1 (pig reduced), 1-de-L-cysteine-2-de-L-serine-3-de-L-cysteine-4-de-L-serine-5-de-L-serine-6-de-L-leucine-7-de-L-methionine-8-de-L-aspartic acid-9-de-L-lysine-10-de-L-glutamic acid-, cyclic (11-15)-disulfide. CAS No. 144602-02-8. Molecular formula: C68H92N14O15S2. Mole weight: 1410.00. | |
| IRL-2500 | IRL-2500, an indol derivative, has been found to be an endothelin B receptor antagonist that was once studied in hypertension. Synonyms: IRL-2500; IRL2500; CHEMBL72410; (2S)-2-[[(2R)-2-[(3,5-dimethylbenzoyl)-methylamino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid. Grades: 98%. CAS No. 169545-27-1. Molecular formula: C36H35N3O4. Mole weight: 573.68. | |
| Irsenontrine | Irsenontrine is a phosphodiesterase (PDE) 9 inhibitor for the treatment of lewy body dementia and Parkinson's disease dementia. Synonyms: 7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-[(3S)-oxolan-3-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one; (S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-pyrazolo[4,3-c]quinolin-4(5H)-one; 4H-Pyrazolo(4,3-c)quinolin-4-one, 1,5-dihydro-7-(2-methoxy-3,5-dimethyl-4-pyridinyl)-1-((3S)-tetrahydro-3-furanyl)-; WHO11606; WHO-11606; WHO 11606. Grades: >98%. CAS No. 1429509-82-9. Molecular formula: C22H22N4O3. Mole weight: 390.44. | |
| Irsogladine | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Uses: Anti-ulcer agents. Synonyms: Irsogladine; 57381-26-7; dicloguamine; 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine; Irsogladine [INN]; 1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-; QBX79NZC1D; 2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine;[4-amino-6-(2,5-dichlorophenyl)-s-triazin-2-yl]amine; maleic acid; (Z)-2-butenedioic acid; 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine; 6-[2,5-bis(chloranyl)phenyl]-1,3,5-triazine-2,4-diamine; (Z)-but-2-enedioic acid. Grades:>98%. CAS No. 57381-26-7. Molecular formula: C9H7Cl2N5. Mole weight: 256.09. | |
| Irsogladine Maleate | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. It inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice. It up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. It also produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions. Synonyms: Dicloguamine maleate; MN1695; MN 1695; MN-1695. Grades: >98%. CAS No. 84504-69-8. Molecular formula: C13H11Cl2N5O4. Mole weight: 372.16. | |
| ISAM 140 | ISAM 140 is a potent and highly selective A2B adenosine receptor antagonist (A2BAR) with Ki value of 3.49 nM. It shows high affinity for A2B over A1, A2A, and A3 adenosine receptors. Synonyms: ISAM-140; ISAM 140; ISAM140; 4-(2-Furanyl)-4,10-dihydro-2-methylpyrimido[1,2-a]benzimidazole-3-carboxylic acid-1-methylethyl ester; (±)-Isopropyl 4-(Furan-2-yl)-2-methyl-1,4-dihydrobenzo-[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate. Grades: ≥98% by HPLC. CAS No. 932191-62-3. Molecular formula: C19H19N3O3. Mole weight: 337.37. | |
| Isamoltane hemifumarate | Isamoltane hemifumarate, an analog of isamoltane, is a beta-adrenoceptor ligand with approximately 30-fold selective over 5-HT1A. Synonyms: 2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(1H-pyrrol-1-yl)phenoxy]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(1H-pyrrol-1-yl)phenoxy]-, (2E)-2-butenedioate (2:1) (salt); Isamoltane fumarate (2:1); 1-(2-(1H-pyrrol-1-yl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; 1-(Isopropylamino)-3-[2-(1H-pyrrol-1-yl)phenoxy]-2-propanol hemifumarate. Grades: ≥99% by HPLC. CAS No. 874882-92-5. Molecular formula: C16H22N2O2.1/2C4H4O4. Mole weight: 332.40. | |
| Isatin | Isatin is an indole derivative used as an intermediate. It also acts as an endogenous MAO inhibitor with an IC50 value of 15 μM. Synonyms: 1H-indole-2,3-dione. CAS No. 91-56-5. Molecular formula: C8H5NO2. Mole weight: 147.13. | |
| ISCK03 | ISCK03, a phenyl-imidazolosulfonamide compound, is a cell-permeable, specific SCF/c-Kit inhibitor (IC50 <<2.5 μM in cell-free kinase assays). Synonyms: 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide; c-Kit Inhibitor II; Stem-Cell Factor/c-Kit Inhibitor; ISCK-03; ISCK 03. CAS No. 945526-43-2. Molecular formula: C19H21N3O2S. Mole weight: 355.45. | |
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