BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GYKI-46903 HCl | GYKI-46903 is a Muscarinic M3 receptor and Serotonin 3 receptor antagonist. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron binding to rat cerebral cortex membranes were 6.91. No development was reported for the treatment of Cognition disorders, Nausea and vomiting. Uses: Cognition disorders; nausea and vomiting. Synonyms: GYKI-46903; GYKI 46903; GYKI46903; GYKI-46,903; GYKI 46,903; GYKI46,903; (4R,5R)-6-(4-fluorophenyl)-1-azabicyclo[3.3.1]non-6-en-4-yl propionate hydrochloride. Grades: 98%. CAS No. 142999-59-5. Molecular formula: C17H21ClFNO2. Mole weight: 325.81. |  |
| GYKI-47261 | GYKI-47261 is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM) and a CYP2E1 inducer. GYKI-47261 shows broad spectrum anticonvulsive activity and neuroprotective effects in vivo. Synonyms: 4-(8-chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline; GYKI 47261; GYKI47261; GYKI-47261. Grades: >99 %. CAS No. 220445-20-5. Molecular formula: C18H15ClN4. Mole weight: 322.796. | |
| GYKI 47261 dihydrochloride | This active molecular is Non-competitiv a AMPA antagonist with IC50 value of 2.5 μM. GYKI-47261 is also a CYP2E1 inducer. GYKI-47261 showed broad spectrum of anticonvulsive and really good neuroprotective effect in vivo. AMPA and NMDA receptors have been implicated in the regulation of corticostriatal synaptic efficacy which abundantly expressed on striatal medium spiny neurons. In 2000, preclinical development for Epilepsy in Hungar was on-going, but no development was reported yet. Uses: Epilepsy; parkinson's disease; stroke. Synonyms: GYKI 47261 dihydrochloride; GYKI47261 dihydrochloride; GYKI-47261 dihydrochloride; 4-(8-chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline;dihydrochloride;220445-20-5 (free base). Grades: 98%. CAS No. 1217049-32-5. Molecular formula: C18H17Cl3N4. Mole weight: 395.71. | |
| GYKI-52466 | GYKI-52466 is a non-competitive AMPA receptor antagonist. It belongs to 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist. It has anticonvulsant and neuroprotective properties. It is an orally-active anticonvulsant and skeletal muscle relaxant. It also was found to have therapeutic potential for cocaine addiction treatment. Uses: Gyki-52466 is an orally-active anticonvulsant and skeletal muscle relaxant. it also was found to have therapeutic potential for cocaine addiction treatment. Synonyms: 4-(8-Methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline;GYKI-52466; GYKI52466; GYKI 52466; GYKI-5,2466; GYKI52,466; GYKI 52,466. Grades: >99 %. CAS No. 102771-26-6. Molecular formula: C17H15N3O2. Mole weight: 293.33. | |
| GYKI 53655 | GYKI 53655 is a selective AMPA receptor antagonist with anticonvulsant activity. Synonyms: GYKI 53655; GYKI53655; GYKI-53655; 5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide. Grades: 99%. CAS No. 143692-18-6. Molecular formula: C19H20N4O3. Mole weight: 352.39. | |
| GYKI 53655 hydrochloride | GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist displaying anticonvulsant activity. It also acts as a blocker of GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. GYKI 53655 prolongs the survival time after MgCl2- induced global cerebral ischemia. Synonyms: GYKI53655 Hydrochloride; GYKI53655 HCl; GYKI53655; GYKI 53655; GYKI-53655. LY 300168 hydrochloride; LY300168 hydrochloride; LY-300168 hydrochloride; 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride; 5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 143692-48-2. Molecular formula: C19H20N4O3.HCl. Mole weight: 388.85. | |
| GYKI 53784 | GYKI-53784, a dioxolbenzene derivative, has been found to be a AMPA receptor antagonist that could block excitotoxicity and decrease auditory nerve activity at some extent. Synonyms: GYKI-53784; GYKI53784; GYKI 53784; LY 303070; LY-303070; LY303070; 7H-1,3-Dioxolo(4,5-h)(2,3)benzodiazepine-7-carboxamide, 8,9-dihydro-5-(4-aminophenyl)-N,8-dimethyl-, (R)-; UNII-91N8O25H4L; AC1MIO7T. Grades: 98%. CAS No. 161832-71-9. Molecular formula: C19H20N4O3. Mole weight: 352.39. | |
| GZD824 | GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50) values of 0.2 and 0.13 nM, respectively. It also displayed good oral bioavailability (48.7%), a reasonable half-life (10.6 h), and promising in vivo antitumor efficacy. GZD824 induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT) or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I). Synonyms: GZD824; GZD 824; GZD-824. Grades: >98%. CAS No. 1257628-77-5. Molecular formula: C29H27F3N6O. Mole weight: 532.56. | |
| H10 | H10 is a potent and cell-active PARP14 inhibitor (IC50 = 490 nM), which exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Synonyms: 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid. Grades: ≥98% by HPLC. CAS No. 2084811-68-5. Molecular formula: C24H27N7O7S. Mole weight: 557.58. | |
| H-1152 Dihydrochloride | H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. It inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. It selectively blocks lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells. Synonyms: (S) - (+) -2-Methyl-1-[ (4-methyl-5-isoquinolynyl) sulfonyl]homopiperazine Dihydrochloride;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline dihydrochloride;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrochloride. Grades: >98 %. CAS No. 871543-07-6. Molecular formula: C16H23Cl2N3O2S. Mole weight: 392.34. | |
| H 151 | H 151 is a highly potent, selective STING antagonist, which reduces TBK1 phosphorylation and suppresses human STING palmitoylation. Synonyms: H-151; H151; Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-; N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea; N-(4-Ethylphenyl)-N'-1H-indol-3-ylurea; H 151 (pharmacological agent). Grades: ≥98%. CAS No. 941987-60-6. Molecular formula: C17H17N3O. Mole weight: 279.34. | |
| H-7 dihydrochloride | H-7 dihydrochloride is a protein kinase inhibitor (IC50 = 6.0, 5.8, 3.0 and 97.0 μM for inhibition of PKC, PKG, PKA and myosin light chain kinase, respectively). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. It was also shown to inhibit Topo I and II in murine L929 cells and induce apoptosis via PKC inhibition. Synonyms: H7 dihydrochloride; H7 HCl. (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 108930-17-2. Molecular formula: C14H17N3O2S.2HCl. Mole weight: 364.29. | |
| H-9 dihydrochloride | H-9 dihydrochloride is a protein kinase inhibitor. It inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM). H-9 hydrochloride reduces the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons2 and inhibits PKA-mediated phosphorylation in a rat seizure model. Synonyms: H-9 dihydrochloride; H 9 dihydrochloride; H9 dihydrochloride; N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 116700-36-8. Molecular formula: C11H13N3O2S.2HCl. Mole weight: 324.22. | |
| HA-1077 dihydrochloride | HA-1077 is a potent and selective inhibitor of Rho kinase (ROCK). HA-1077 exhibited neuroprotective effects and enhanced cognition in mouse models of amyotrophic lateral sclerosis (ALS), suggesting its potential use for cognitive disorders such as ALS, Alzheimer's disease and spinal muscular atrophy. It also suppresses tumor cell motility and metastasis. Synonyms: Fasudil dihydrochloride; 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride. Grades: ≥98%. CAS No. 203911-27-7. Molecular formula: C14H17N3O2S·2HCl. Mole weight: 364.3. | |
| HA-130 | HA-130, an effective autotaxin (ATX) inhibitor, has been found to restrain the cell migration related to ATX in in an A2058 melanoma cells. IC50: 28 nM. Uses: Ha-130 is an effective autotaxin (atx) inhibitor that has been found to restrain the cell migration related to atx in in an a2058 melanoma cells. Synonyms: SCHEMBL1555945; 1229652-21-4; HA130; HA-130; HA 130. Grades: >98 %. CAS No. 1229652-21-4. Molecular formula: C24H19BFNO5S. Mole weight: 463.29. | |
| HA14-1 | HA14-1 is a potent Bcl-2 inhibitor with potential anticancer activity. HA14-1 induces apoptosis in various human cancer cells. HA14-1 suppressed NF-kappaB activation through inhibition of phosphorylation and degradation of IkappaBalpha. Synonyms: HA-141, HA 141, HA141. CAS No. 65673-63-4. Molecular formula: C17H17BrN2O5. Mole weight: 409.23. | |
| Halofantrine Hydrochloride | Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel used to treat malaria. Uses: A blocker of delayed rectifier potassium. Synonyms: 1,3-dichloro-alpha-[2-(dibutylamino)ethyl]-6- (trifluoromethyl)-9-phenathrenemethanol hydrochloride; halofantrine hydrochloride; 1,3-dichloro-alpha-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride; Halofantarine HCL; Halfan, 1. Grades: >98% BP/EP. CAS No. 36167-63-2. Molecular formula: C26H30Cl2F3NO.ClH. Mole weight: 536.89. | |
| Halopemide | Halopemide is a potent inhibitor of phospholipase D (PLD), and also a dopamine blocker. It is structurally related to butyrophenones and acts as a psychotropic agent, without parkinsonian side effects. Synonyms: NSC 354856; R34301; N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide. Grades: ≥98%. CAS No. 59831-65-1. Molecular formula: C21H22ClFN4O2. Mole weight: 416.9. | |
| Haloperidol hydrochloride | Haloperidol hydrochloride is a dopamine antagonist that specifically targets D2-like receptors, with effect to treat schizophrenia, acute psychosis, and delirium. And it is also a non-competitive inhibitor of NOS1 (nNOS). Ki: D2 receptors=1.2, D3 receptor. Synonyms: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one;hydrochloride haloperidol hydrochloride UNII-UM06W2ADRY UM06W2ADRY Haloperidol (hydrochloride) CHEMBL545608 1511-16-6. CAS No. 1511-16-6. Molecular formula: C21H24Cl2FNO2. Mole weight: 412.33. | |
| Haloprogin | Haloprogin is an antifungal drug. It can be used for the treatment of athlete's foot and other fungal infections. Uses: Athlete's foot and other fungal infections. Synonyms: M 1028; NSC 100071; M1028; NSC100071; M-1028; NSC-100071; 1,2,4-Trichloro-5-[(3-iodo-2-propynyl)oxy]benzene; 2,4,5-Trichlorophenyl γ-Iodopropargyl Ether; 3-Iodo-2-propynyl 2,4,5-Trichlorophenyl Ether; 1,2,4-Trichloro-5-[(3-iodo-2-propyn-1-yl)oxy]benzene. Grades: 98%. CAS No. 777-11-7. Molecular formula: C9H4Cl3IO. Mole weight: 361.39. | |
| Halopyramine | Halopyramine is known as a competitive reversible H1-receptor antagonist. It exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. It inhibits the vasodilation, increased vascular permeability, and tissue edema associated with histamine release in the tissue by blocking the effects of histamine. It is a first generation antihistamine drug for the treatment of allergic rhinitis, allergic conjunctivitis, bronchial asthma, and other allergic conditions. It has been listed. Uses: Halopyramine is a first generation antihistamine drug for the treatment of allergic rhinitis, allergic conjunctivitis, bronchial asthma, and other allergic conditions. Synonyms: Chloropyramine;1,2-Ethanediamine, N-[(4-chlorophenyl)methyl]-N', N'-dimethyl-N-2-pyridinyl-; 2-((p-Chlorobenzyl)(2-(dimethylamino)ethyl)amino)pyridine; Allergan; Anaphylline; Avapena; Suprastin; Synopen; N'-[(4-chlorophenyl)methyl]-N, N-dimethyl-N'-pyridin-2-yleth. Grades: 98%. CAS No. 59-32-5. Molecular formula: C16H20ClN3. Mole weight: 289.81. | |
| Haloxon | Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants. Synonyms: Haloxon. Grades: >98%. CAS No. 321-55-1. Molecular formula: C14H14Cl3O6P. Mole weight: 415.59. | |
| HAMI3379 | HAMI3379 is a cysteinyl leukotriene 2 (CysLT2) receptor antagonist. It can inhibit radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >30,000 nM. In a CysLT2 receptor reporter cell line, it can antagonize LTD4- and LTC4-induced intracellular calcium mobilization with IC50 values of 3.8 and 4.4 nM, respectively, but it only weakly inhibits that for a CysLT1 receptor reporter cell line with IC50 value >10,000 nM. HAMI3379 may represent a new type of therapeutic agent in the treatment of ischemic stroke. Uses: Ischemic stroke. Synonyms: HAMI3379; HAMI-3379; HAMI 3379; CHEMBL3342944;GTPL6197; SCHEMBL4518791; DTXSID80439859; 3-[ (3-carboxycyclohexyl) carbamoyl]-4-[3-[4- (4-cyclohexyloxybutoxy) phenyl]propoxy]benzoic acid. Grades: 90%. CAS No. 712313-35-4. Molecular formula: C34H45NO8. Mole weight: 595.73. | |
| HAT Inhibitor II | HAT Inhibitor II is a cell-permeable and selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 μM). It has been shown to decrease histone H3 acetylation (IC50 ≤ 40 μM) and induce chromatin condensation in HeLa cells. Synonyms: Histone Acetyltransferase Inhibitor II; (2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one. Grades: ≥98%. CAS No. 932749-62-7. Molecular formula: C20H16Br2O3. Mole weight: 464.2. | |
| HBX 19818 | HBX 19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3, showing this compound's specificity for USP7 over a panel of active DUBs under physiological conditions proved to be active in cells, as it almost completely inhibited USP7 labeling at 25 mM. MS/MS spectrum revealed that HBX 19,818 is attached to Cys315. Based on UV chromatogram (l = 332 nm) peak areas, HBX 19,818 partially reverses the deubiquitination of Mdm2 by USP7 in HEK293 cells, confirming that HBX 19,818 inhibits a biological activity of USP7 in living cells. HBX 19,818 has additional off-target, p53-independent proapoptotic effects. Synonyms: HBX19818; HBX-19818. Grades: >98%. CAS No. 1426944-49-1. Molecular formula: C25H28ClN3O. Mole weight: 421.96. | |
| HC-067047 | HC-067047 is a potent and selective TRPV4 antagonist. It has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis. HC-067047 also attenuated allodynia in diabetic mice, suggesting its potential application for the treatment of painful diabetic neuropathy (PDN). Synonyms: HC 067047; HC067047; 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide. Grades: ≥98%. CAS No. 883031-03-6. Molecular formula: C26H28F3N3O2. Mole weight: 471.5. | |
| HCV-IN-4 | HCV-IN-4 is a potent and orally bioactive HCV NS5A inhibitor, displaying great potency against GT1a, GT2b, GT3a, GT1a Y93H and GT1a L31V, with EC90s values of 3 pM, 0.3 nM, 0.01 nM, 0.5 nM and 0.02 nM, respectively. Synonyms: HCV-IN-4|CHEMBL3980210|HY-P0162|CS-0020242. Grades: ≥98% (HPLC). CAS No. 2058080-25-2. Molecular formula: C52H58FN9O8. Mole weight: 956.07. | |
| HDAC3 Inhibitor | HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM, IC50s = 0.95 nM). HDAC3 inhibitors increase histone acetylation and restore normal transcriptional patterns. Treatment with inhibitors primarily targeting HDAC3, including some with additional activity on HDAC1, led to improvement in motor function and working memory in N-terminal transgenic HD mice. Synonyms: Histone Deacetylase 3 Inhibitor; (E) -3-Phenyl-N-[[4- (propylaminocarbamoyl) phenyl]methyl]prop-2-enamide. Grades: ≥98%. CAS No. 2044701-99-5. Molecular formula: C20H23N3O2. Mole weight: 337.4. | |
| HDAC-IN-1 | HDAC-IN-1, an analogue of MC 1568, is a Iia HDACs inhibitor that could probably influence myogenesis and adipogenesis. Uses: Hdac-in-1 is a iia hdacs inhibitor that could probably influence myogenesis and adipogenesis. Synonyms: MC1568; MC 1568; MC-1568; HDAC-IN-1; HDAC IN 1. Grades: 98%. CAS No. 1239610-44-6. Molecular formula: C17H15FN2O3. Mole weight: 314.31. | |
| HDAC-IN-2 | HDAC-IN-2, a selective HDAC inhibitor, has been found to probably restrain the transcription and division of tumor oncogene and could also lead to the apoptosis of tumor cells.It is under Phase II trials against Multiple myeloma. IC50: 4 nM and 76 nM for. Uses: Hdac-in-2 is a selective hdac inhibitor that has been found to probably restrain the transcription and division of tumor oncogene and could also lead to the apoptosis of tumor cells.it is under phase ii trials against multiple myeloma. Synonyms: ACY-241; ACY 241; ACY241; HDAC-IN-2; Citarinostat; 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-441P620G3P; 441P620G3P; Citarinostat. Grades: 98%. CAS No. 1316215-12-9. Molecular formula: C24H26ClN5O3. Mole weight: 467.95. | |
| HDS 029 | HDS 029 is a potent inhibitor of the ErbB receptor family including EGFR, ErbB2 and ErbB4 (IC50 = 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2, respectively). HDS 029 inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 = 2.5 and 24 nM, respectively). Synonyms: HDS 029; HDS 029; HDS 029; N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide; EGFR/ErbB-2/ErbB-4 Inhibitor. Grades: ≥97% by HPLC. CAS No. 881001-19-0. Molecular formula: C17H11ClFN5O. Mole weight: 355.76. | |
| HEAT hydrochloride | HEAT hydrochloride is a selective α1-adrenoceptor antagonist, precursor to the 3-[125I]-derivative. Synonyms: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride; BE 2254; BE2254; BE-2254. Grades: ≥98% by HPLC. CAS No. 30007-39-7. Molecular formula: C19H21NO2.HCl. Mole weight: 331.84. | |
| Heat Shock Protein Inhibitor II | Heat shock protein (HSP) inhibitor II is the active metabolite of Hsp inhibitor I and suppresses the synthesis of inducible HSPs, such as HSP105, HSP72, and HSP40. Synonyms: HSP Inhibitor II; KNK 423; (3E)-3-(1,3-benzodioxol-5-ylmethylidene)pyrrolidin-2-one. Grades: ≥98%. CAS No. 1859-42-3. Molecular formula: C12H11NO3. Mole weight: 217.2. | |
| Helioxanthin | Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture model. Helioxanthin analogue 8-1 exhibited anti-DHBV activity as demonstrated by quantification of viral DNA, RNA, covalently closed circular DNA and protein synthesis. Analogue 8-1 did not affect the stability of cellular macromolecules and did not have a sustained antiviral effect after drug removal. When DHBV replication was induced, virus-harbouring cells were more susceptible to the cytotoxicity of 8-1 than non-induced cells. Synonyms: ACH-126447; ACH 126447; ACH126447; HE-145; HE 145; HE145. Helioxanthin. Grades: >98%. CAS No. 18920-47-3. Molecular formula: C20H12O6. Mole weight: 348.31. | |
| Helioxanthin 8-1 | Helioxanthin 8-1 is an analogue of helioxanthin, which exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity. It showed the most potent antiHBV activity among those helioxanthin analogues tested. It exhibited moderately potent activity against HIV and effective inhibition on DHBV replication. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam. Synonyms: Helioxanthin 8 1; Helioxanthin analogue 8-1; Helioxanthin analogue 8 1. Grades: >98%. CAS No. 840529-13-7. Molecular formula: C20H12N2O6. Mole weight: 376.32. | |
| Helioxanthin derivative 5-4-2 | Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively. Synonyms: Helioxanthin 5-4-2; Helioxanthin 5 4 2. Grades: >98%. CAS No. 203935-39-1. Molecular formula: C20H13NO5. Mole weight: 347.32. | |
| Hellebrin | Hellebrin is a cardiotoxin that acts as an ATPase inhibitor. It potently inhibits the Na+/K+-ATPase and was shown to significantly reduce the oxygen consumption rate in cardenolide- and bufadienolide-treated cells, reflecting a direct impact on mitochondrial oxidative phosphorylation. It exhibits anticancer effects. Synonyms: NSC 93134; Neuro_000039. Grades: ≥99%. CAS No. 13289-18-4. Molecular formula: C36H52O15. Mole weight: 724.8. | |
| HEMADO | HEMADO is a selective and high affinity adenosine A3 receptor agonist (Ki = 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors, respectively). Synonyms: 2-(1-Hexynyl)-N-methyladenosine. Grades: ≥99% by HPLC. CAS No. 403842-38-6. Molecular formula: C17H23N5O4. Mole weight: 361.4. | |
| Hemopressin (human, mouse) | Hemopressin (human, mouse) is a bioactive endogenous peptide substrate for endopeptidase 24.15, neurolysin and ACE (Ki = 27.76, 3.43 and 1.87 μM, respectively). Hemopressin (human, mouse) acts as a selective CB1 receptor inverse agonist with antinociceptive and hypotensive activity. Synonyms: Hemopressin (human, mouse); 1314035-51-2; (2S) -2- [ [ (2S) -2- [ [ (2S) -2- [ [ (2S) -2- [ [ (2S) -6-amino-2- [ [ (2S) -2- [ [ (2S) -4-amino-2- [ [ (2S) -3-methyl-2- [ [ (2S) -pyrrolidine-2-carbonyl] amino] butanoyl] amino] -4-oxobutanoyl] amino] -3-phenylpropanoyl] amino] hexanoyl] amino] -4-methylpentanoyl] amino] -4-methylpentanoyl] amino] -3-hydroxypropanoyl] amino] -3- (1H-imidazol-5-yl) propanoic acidHemopressin (human, bovine, porcine) trifluoroacetate salt H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH trifluoroacetate salt; HY-P1091. CAS No. 1314035-51-2. Molecular formula: C50H79N13O12. Mole weight: 1054.26. | |
| Hemopressin (rat) | Hemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15, neurolysin and ACE (Ki = 27.76, 3.43 and 1.87 μM, respectively). Hemopressin (rat) acts as a selective CB1 receptor inverse agonist with antinociceptive and hypotensive activity. Synonyms: hemopressin; Hemopressin (rat); 568588-77-2; Hemopressin(rat); CHEMBL510801; PVNFKFLSH; DTXSID301029393; HY-P1090; BDBM50242451; AKOS024456765; CS-0027673; Q5712532; (2S) -2- [ [ (2S) -2- [ [ (2S) -2- [ [ (2S) -2- [ [ (2S) -6-amino-2- [ [ (2S) -2- [ [ (2S) -4-amino-2- [ [ (2S) -3-methyl-2- [ [ (2S) -pyrrolidine-2-carbonyl] amino] butanoyl] amino] -4-oxobutanoyl] amino] -3-phenylpropanoyl] amino] hexanoyl] amino] -3-phenylpropanoyl] amino] -4-methylpentanoyl] amino] -3-hydroxypropanoyl] amino] -3- (1H-imidazol-5-yl) propanoic acid. CAS No. 568588-77-2. Molecular formula: C53H77N13O12. Mole weight: 1088.27. | |
| Heneicosapentaenoic acid | Heneicosapentaenoic acid (HPA) is a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid. Grades: ≥95%. CAS No. 24257-10-1. Molecular formula: C21H32O2. Mole weight: 316.5. | |
| Heneicosapentaenoic acid methyl ester | Heneicosapentaenoic acid methyl ester is a derivative of heneicosapentaenoic acid (HPA), a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA methyl ester; Methyl 6,9,12,15,18-heneicosapentaenoate; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid methyl ester; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid methyl ester. Grades: ≥98%. CAS No. 65919-53-1. Molecular formula: C22H34O2. Mole weight: 330.5. | |
| Hesperadin | Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential for infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors. Synonyms: Hesperadin. Grades: ≥98% (HPLC). CAS No. 422513-13-1. Molecular formula: C29H32N4O3S. Mole weight: 516.65. | |
| Hetacillin potassium | Hetacillin potassium is a penicillin beta-lactam antibiotic reatment for use against a wide range of common Gram-positive and Gram-negative bacteria. Uses: A penicillin beta-lactam antibiotic. Synonyms: potassium;(2S,5R,6R)-6-[(4R)-2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. Grades: ≥95%. CAS No. 5321-32-4. Molecular formula: C19H22KN3O4S. Mole weight: 427.56. | |
| Hexadecyl acetyl glycerol | Hexadecyl acetyl glycerol (HAG) is an inhibitor of protein kinase C (PKC). It also inhibits the growth and induces differentiation of HL-60 cells. Synonyms: HAG; 1-O-Hexadecyl-2-acetyl-sn-glycerol; 1-Palmityl-2-acetylglycerol; (S)-1-(Hexadecyloxy)-3-hydroxypropan-2-yl acetate. Grades: ≥90%. CAS No. 77133-35-8. Molecular formula: C21H42O4. Mole weight: 358.6. | |
| Hexadecyl methyl glycerol | Hexadecyl methyl glycerol is a synthetic diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. It inhibits protein kinase C (PKC) activity in human neutrophils. Synonyms: 1-O-hexadecyl-2-O-methyl-sn-glycerol. Grades: ≥98%. CAS No. 96960-92-8. Molecular formula: C20H42O3. Mole weight: 330.6. | |
| Hexamethonium Bromide | Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia. Synonyms: Hexamethionium bromide; Esametina; Simpatoblock; Vegolysen. Grades: >98%. CAS No. 55-97-0. Molecular formula: C12H30N2.2Br. Mole weight: 362.19. | |
| HexylHIBO | HexylHIBO is a Group I mGlu receptor antagonist (Ki = 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively). HexylHIBO was shown to decrease sEPSCs in rat pyramidal neurons in vitro. Synonyms: α-Amino-4-hexyl-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid; Hexylhomoibotenic acid. Grades: ≥98% by HPLC. CAS No. 334887-43-3. Molecular formula: C12H20N2O4. Mole weight: 256.3. | |
| HG-10-102-01 | HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM) IC50 Value: 23.3 nM (WT LRRK2); 3.2 nM (LRRK2 G2019S) [1] Target: LRRK2 HG-. Synonyms: HG-10-102-01; HG 10-102-01; HG10-102-01; HG-1010201; HG 1010201; HG1010201; LRRK2 inhibitor 1. Grades: >98%. CAS No. 1351758-81-0. Molecular formula: C17H20ClN5O3. Mole weight: 377.83. | |
| HG-14-10-04 | HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. Synonyms: HG-14-10-04. Grades: >98%. CAS No. 1356962-34-9. Molecular formula: C29H34ClN7O. Mole weight: 532.08. | |
| HG6-64-1 | HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. Synonyms: HG-6-64-1; HG 6 64 1; HG6641. Grades: >98%. CAS No. 1315329-43-1. Molecular formula: C32H34F3N5O2. Mole weight: 577.64. | |
| HIF Phd Inhibitor 4 | An inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD). Synonyms: N-(4-Chlorobenzyl)-3-(5,6-dimethoxy-2-pyridinyl)-2,4-dioxo-1. Grades: 98%. CAS No. 1227946-51-1. Molecular formula: C21H17ClN4O5S. Mole weight: 472.9. | |
| Histamine | Histamine is an organic nitrogenous compound produced by basophils and by mast cells found in nearby connective tissues. Uses: An organic nitrogenous compound. Synonyms: 1h-imidazole-4-ethanamine;2-(4-IMIDAZOLYL)ETHYLAMINE;2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE;4-(2-Aminoethyl)-1H-imidazole;HISTAMINE BASE;HISTAMIN. Grades: ≥97%. CAS No. 51-45-6. Molecular formula: C5H9N3. Mole weight: 111.15. | |
| HIV-1 integrase inhibitor | HIV-1 integrase inhibitor is uesful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. Synonyms: (Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid. Grades: >98%. CAS No. 544467-07-4. Molecular formula: C11H9N3O4. Mole weight: 247.21. | |
| HIV-1 integrase inhibitor 2 | HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. It did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase. Synonyms: CX04328; CX-04328; CX 04328; 3-Quinolineacetic acid, 6-chloro-2-methyl-4-phenyl-a-propyl-. Grades: >98%. CAS No. 957890-42-5. Molecular formula: C21H20ClNO2. Mole weight: 353.84. | |
| HKI 357 | HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proliferation of NCI-H1975 cells containing L858R and T790M mutations. Uses: Antitumor agent. Synonyms: HKI 357; HKI357; HKI-357; (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Grades: ≥98% by HPLC. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. | |
| HLCL-61 hydrochloride | The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia. Uses: The hydrochloride salt form of hlcl-61 is an effective inhibitor of prmt5 and could probably useful in the treatment of acute myeloid leukemia. Synonyms: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride; HLCL61; HLCL 61; HLCL-61. Grades: 98%. CAS No. 1158279-20-9. Molecular formula: C23H25ClN2O. Mole weight: 380.91. | |
| HLY78 | HLY78 is an activator of the Wnt/β-catenin pathway. It targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. In zebrafish embryos, HLY78 was shown to increase the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb. Synonyms: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine. Grades: ≥98%. CAS No. 854847-61-3. Molecular formula: C17H17NO2. Mole weight: 267.3. | |
| HMB-Val-Ser-Leu-VE | HMB-val-ser-leu-VE is a potent and selective inhibitor of the trypsin-like activity of the 20S proteasome. Synonyms: Ethyl (E, 4S) -4- [ [ (2S) -3-hydroxy-2- [ [ (2S) -2- [ (3-hydroxy-2-methylbenzoyl) amino] -3-methylbutanoyl] amino] propanoyl] amino] -6-methylhept-2-enoate. Grades: ≥98%. CAS No. 862891-04-1. Molecular formula: C26H39N3O7. Mole weight: 505.6. | |
| HMR 1098 | HMR 1098 is a KATP channel antagonist inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. HMR 1098 is an inhibitor of Kir6.2/SUR1-composed K(ATP) channels. Synonyms: HMR 1098; HMR1098; HMR-1098; 5-chloro-2-methoxy-n-[2-[4-methoxy-3- (3-methylthioureidosulfonyl) phenyl]ethyl]benzamide sodium salt. Grades: 98%. CAS No. 261717-22-0. Molecular formula: C19H21ClN3NaO5S2. Mole weight: 493.96. | |
| HNHA | HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) (IC50 = 100 nM). HNHA exhibits activity aganist various cancers like breast cancer and anaplastic thyroid cancer (ATC). Synonyms: Histone Deacetylase Inhibitor VI; N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide. Grades: ≥98%. CAS No. 926908-04-5. Molecular formula: C17H21NO2S. Mole weight: 303.4. | |
| HNMPA | HNMPA is a cell-impermeable insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Synonyms: Hydroxy-2-naphthalenylmethyl phosphonic acid. Grades: ≥95%. CAS No. 132541-52-7. Molecular formula: C11H11O4P. Mole weight: 238.2. | |
| HNMPA-(AM)3 | HNMPA-(AM)3 is a cell-permeable analog of HNMPA, an insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Synonyms: Hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester. Grades: ≥95%. CAS No. 120944-03-8. Molecular formula: C20H23O10P. Mole weight: 454.4. | |
| Hoku-81 | Hoku 81 is a bronchodilator, and one of the metabolites of tulobuterol. Uses: Bronchodilators,metabolite of tulobuterol. Synonyms: Hoku 81; Hoku-81; Hoku81. 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol;2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-benzenemethanol;4-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol. Grades: ≥98%. CAS No. 58020-43-2. Molecular formula: C12H18ClNO2. Mole weight: 243.73. | |
| Homoquinolinic acid | Homoquinolinic acid is a potent NMDA receptor agonist and neurotoxic agent. Synonyms: 3-Pyridineacetic acid, 2-carboxy-; 2-carboxy-3-Pyridineacetic acid; Homoquinolinate; 3-(carboxymethyl)pyridine-2-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 490-75-5. Molecular formula: C8H7NO4. Mole weight: 181.15. | |
| HPGDS-inhibitor-1 | HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM. Synonyms: MDK36122; MDK36122; MDK-36122; H-PGDS Inhibitor I; Prostaglandin D Synthase (hematopoietic-type) Inhibitor I. CAS No. 1033836-12-2. Molecular formula: C19H19F4N3O. Mole weight: 381.3746. | |
| HPI 1 | HPI 1 is a hedgehog (Hh) signaling inhibitor that blocks Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 = 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation) with no effect on Wnt signaling. HPI 1 also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM), and prevents the proliferation of cerebellar granule neuron precursors expressing SmoM2. Synonyms: HPI 1; HPI1; HPI-1; 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester. Grades: ≥95% by HPLC. CAS No. 599150-20-6. Molecular formula: C27H29NO6. Mole weight: 463.52. | |
| HPP854 | HPP854, developed by High Point Pharmaceuticals, is a small molecule BACE1 protein inhibitor. Phase 1. Synonyms: HPP854; TTP-854. | |
| HS 014 | HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki = 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors, respectively). HS 014 promotes food intake in rats and nociception in mice following central administration in vivo. HS 014 also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus. Synonyms: HS 014; HS014; HS-014. CAS No. 207678-81-7. Molecular formula: C71H94N20O17S2. Mole weight: 1563.77. | |
| HS 024 | HS 024 is a potent melanocortin MC4 receptor antagonist (Ki = 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors, respectively). HS 024 promotes food intake, blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo. Synonyms: Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide; N-acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinamide (1->9)-disulfide; Ac-Cys(1)-Nle-Arg-His-D-2Nal-Arg-Trp-Gly-Cys(1)-NH2; HS024; HS-024. Grades: ≥95%. CAS No. 212370-59-7. Molecular formula: C58H79N19O10S2. Mole weight: 1266.52. | |
Our database is helping our users find suppliers everyday.
