BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| FR-188582 | FR-188582, with anti-inflammatory and ulcerogenic properties, is a highly selective inhibitor of COX-2 with IC50=0.017 microM. Synonyms: 3-chloro-5-(4-methylsulfonylphenyl)-1-phenylpyrazole; FR 188582; FR188582; FR-188582. Grades: >98%. CAS No. 189699-82-9. Molecular formula: C16H13ClN2O2S. Mole weight: 332.8. |  |
| FR-193879 | FR-193879, a cephem derivative, is an efficacious anti-Helicobacter pylori cephalosporin. Synonyms: (6R,7R)-3-[[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; FR-193879; FR193879; FR 193879. Grades: >98%. CAS No. 194928-82-0. Molecular formula: C20H18N4O5S3. Mole weight: 490.58. | |
| FR-194921 | FR-194921 is a potent, selective and orally active antagonist for central adenosine A1 receptors that displays high affinity and selectivity for the adenosine A1 receptor (Ki= 2.9 nM) and did not show species differences in binding affinity. Synonyms: 2-(1-methylpiperidin-4-yl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3-one; FR-194921; FR 194921; FR194921; 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-3(2H)-pyridazinone. Grades: >98%. CAS No. 202646-80-8. Molecular formula: C23H23N5O. Mole weight: 385.46. | |
| FR-221647 | FR-221647 is a non-nucleoside adenosine deaminase inhibitor. Synonyms: 1-(1-hydroxy-4-phenylbutan-2-yl)imidazole-4-carboxamide; FR-221647; FR 221647; FR221647. Grades: >98%. CAS No. 256461-28-6. Molecular formula: C14H17N3O2. Mole weight: 259.3. | |
| FR-229934 | FR-229934 is a Type 5 cyclic nucleotide phosphodiesterase inhibitor. In Feb 2008, preclinical for Erectile dysfunction in Japan was discontinued. Uses: Erectile dysfunction. Synonyms: FR-229934; FR229934; FR 229934. 1-((3,4-dichlorophenyl)methyl)-2-methyl-N-(pentylsulfonyl)-1H-Benzimidazole-6-carboxamide. Grades: 98%. CAS No. 799841-02-4. Molecular formula: C21H23Cl2N3O3S. Mole weight: 468.40. | |
| FR-234938 | FR-234938, with anti-inflammatory property, is a non-nucleoside recombinant human adenosine deaminase enzyme inhibitor. Synonyms: 1-[(3R,4S)-4-hydroxy-1-naphthalen-1-ylpentan-3-yl]imidazole-4-carboxamide; FR-234938; FR 234938; FR234938. Grades: >98%. CAS No. 256461-79-7. Molecular formula: C19H21N3O2. Mole weight: 323.39. | |
| FR236913 | FR236913 is a compoundused in studying chronic lymphocytic leukemia (CLL) and other hematologic malignancies. This targeted therapy inhibits Bruton's tyrosine kinase (BTK) is a key enzyme in the B-cell receptor signaling pathway. By disrupting abnormal B-cell signaling, FR236913 helps control the progression of CLL. Synonyms: 1-[(2R)-4-{6-[(Benzylcarbamoyl)amino]-1H-indol-1-yl}-1-hydroxybutan-2-yl]-1H-imidazole-4-carboxamide. Molecular formula: C24H26N6O3. Mole weight: 446.5. | |
| FR 236924 | FR 236924 is a selective PKCε activator with > 7-fold selectivity over other PKC isozymes. FR 236924 promotes glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. It has the potential for the treatment of Alzheimer disease. Synonyms: FR 236924; FR236924; FR-236924; Dcp-LA; 2-[ (2-Pentylcyclopropyl) methyl]cyclopropaneoctanoic acid. Grades: ≥99% by HPLC. CAS No. 28399-31-7. Molecular formula: C20H36O2. Mole weight: 308.5. | |
| FR252384 | FR252384 is novel potent antagonists of human neuropeptide Y-Y5 receptor (IC50= 2.3 nM). Synonyms: FR252384; FR 252384; FR-252384; 9-methyl-2-pyridin-3-yl-3,4,5,6-tetrahydrobenzo[2,3]cyclohepta[2,4-b]imidazole; Benzo[3,4]cyclohept[1,2-d]imidazole, 1,4,5,6-tetrahydro-9-methyl-2-(3-pyridinyl)-. CAS No. 447405-11-0. Molecular formula: C18H17N3. Mole weight: 275.35. | |
| FR-62765 | FR-62765, a derivative of WF-3681, is a novel aldose reductase inhibitor. It might be a useful drug for diabetic neuropathy. Uses: Fr-62765 might be a useful drug for diabetic neuropathy. Synonyms: FR 62765; FR-62765; FR62765. 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester;FR62765;2,5-Dihydro-4-methoxy-5-oxo-3-phenylfuran-2-propanoic acid ethyl ester;Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate;Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate. Grades: >98 %. CAS No. 105346-34-7. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| FR-A 19 | FR-A 19 is a Histamine H2 receptor agonist with potent anti-allergic properties. It can inhibit IgE-mediated human basophil histamine release in a nanomolar range. Uses: Anti-allergic agent. Synonyms: FR-A 19; FR-A-19; FRA19; N,N-bis(3-(4-fluorophenyl)propyl)-N'-(3-(1H-imidazol-4-yl)propyl)-Guanidine trihydrochloride. Grades: 98%. CAS No. 141099-46-9. Molecular formula: C25H34Cl3F2N5. Mole weight: 548.93. | |
| Framycetin sulphate | Cas No. 4146-30-9. | |
| Frentizole | Frentizole is a novel inhibitor of the Aβ-ABAD interaction (IC50 = 200 lM). Frentizole, a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus, displayed a slightly improved activity (IC50 = 200 lM) compared to thioflavine T (IC50 = 230 lM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: LY 53616; LY53616; LY-53616; Frentizole; 1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea; 7EY946394I; frentizole; mono-hydrate of frentizole; FRENTIZOLE; 26130-02-9; Frentizol; Compound 53616; MLS000555007; CHEMBL128988; UNII-7EY946394I; 1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea; NCGC00160657-01; SMR000147124; 1-(6-Methoxy-benzothiazol-2-yl)-3-phenyl-urea; DSSTox_CID_26279; DSSTox_RID_81505; 1-(6-methoxybenzo[d]thiazol-2-yl)-3-phenylurea; DSSTox_GSID_46279; CAS-26130-02-9; Frentizolum; Frenazole; AC1Q4EVH; Frentizole (USAN/INN); Opera_ID_1653; Frentizol [INN-Spanish]; Frentizolum [INN-Latin]; AC1L1PF2; Oprea1_516941; cid_33334; MLS001201824; Bio-0413; Frentizole [USAN:INN:BAN]; SCHEMBL599582; DTXSID5046279; HMS2233G12; HMS3370C02; ZINC8994439; Tox21_111964; 3684AH; BDBM50189352; STK078558; ZINC08994439; AKOS001049350; Tox21_111964_1; 7EY946394I; CS-0841; MCULE-7561551977; NCGC00160657-03; AK468739; DR001179; HE329695; HY-15374; LY 53616; ST50103599; 1-(6-Methoxy-2-benzothiazolyl)-3-phenylurea; 1-(6-methoxybenzothiazol-2-yl)-3-phenylurea; D00159; W-5046; Urea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-; 3-(6-methoxy-1,3-benzothiazol-2-yl)-1-phenylurea; N-(6-methoxybenzothiazol-2-yl)(phenylamino)carboxamide; T0510-0233. CAS No. 26130-02-9. Molecular formula: C15H13N3O2S. Mole weight: 299.35. | |
| FRG8701 | FRG-8701 is a novel Histamine H2 receptor antagonist (IC50= 0.25~ 0.43 μM). FRG-8701 has relatively long-lasting antisecretory ef fects in comparison with famotidine and cimetidine. Synonyms: FRG8701;FRG 8701; FRG-8701; 2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide; FRG 8701; FRG-8701; N-(3-(3-(piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide. CAS No. 108498-50-6. Molecular formula: C22H30N2O4S. Mole weight: 418.55. | |
| Frovatriptan succinate hydrate | Frovatriptan is a selective agonist of the 5-HT1B and 5-HT1D (Kis = 2.51 and 3.98 nM, respectively). Synonyms: SB 209509; VML 251; butanedioic acid, compd. with (R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide, hydrate (1:1:1); R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate. Grades: ≥98%. CAS No. 158930-17-7. Molecular formula: C14H17N3O·C4H6O4·H2O. Mole weight: 379.41. | |
| Ftaxilide | Ftaxilide is an antituberculosis agent used as antiseptic. Synonyms: 2-[(2,6-dimethylphenyl)carbamoyl]benzoic acidFtaxilide2',6'-Dimethylphthalanilic acidHistanorm19368-18-4Ftaxilide [INN:DCF]Ftaxilidum [INN-Latin]Ftaxilida [INN-Spanish]Phthalic 2,6-dimethylanilideUNII-7Z71845H3FMP-12-PMP 12; NSC 16112; MP12; NSC16112; MP-12; NSC-16112Phthalanil. CAS No. 19368-18-4. Molecular formula: C16H15NO3. Mole weight: 269.295. | |
| FTI-277 | FTI-277, a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Treatment of H-Ras oncogene-transformed NIH 3T3 cells with FTI-277 blocked recruitment to the plasma membrane and subsequent activation of the serine/threonine kinase c-Raf-1 in cells transformed by farnesylated Ras (H-RasF), but not geranylgeranylated, Ras (H-RasGG). FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells. FTI-277 also inhibited oncogenic K-Ras4B processing and constitutive activation of MAPK, but the concentrations required were 100-fold higher than those needed for H-Ras inhibition. The results demonstrate that FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm, hence preventing constitutive activation of the MAPK cascade. Uses: Radiation-sensitizing agents. Synonyms: FTI-277; FTI 277; FTI277. CAS No. 170006-73-2. Molecular formula: C22H29N3O3S2. Mole weight: 447.612. | |
| FTI 277 HCl | FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. Synonyms: FTI277 HCl; FTI 277 HCl; FTI-277 HCl. Grades: >98%. CAS No. 180977-34-8. Molecular formula: C22H30ClN3O3S2. Mole weight: 484.07. | |
| FTIDC | FTIDC is an orally bioactive mGlu1 receptor negative allosteric modulator (IC50 = 5.8 and 6200 nM for mGlu1 and mGlu5, respectively) and an mGlu1 receptor inverse agonist (IC50 = 7 nM) in the absence of ligand. FTIDC exhibits anxiolytic and antipsychotic effects in vivo. Synonyms: 4-[1-(2-Fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3,6-dihydro-N-methyl-N-(1-methylethyl)-1(2H)-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 873551-53-2. Molecular formula: C18H23FN6O. Mole weight: 358.41. | |
| Funapide | Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is applicated for the treatment of a variety of chronic painconditions, including osteoarthritis, neuropathic pain, postherpetic, neuralgia, erythromelalgia and dental pain. In July 2014, Funapide has reached phase IIb clinical trials. Uses: Chronic painconditions. Synonyms: UNII-A5595LHJ2L; A5595LHJ2L; XEN-401-S; TV-45070; TV 45070; TV45070; XEN402; XEN-402; XEN 402; Funapide.(7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one. Grades: 98%. CAS No. 1259933-16-8. Molecular formula: C22H14F3NO5. Mole weight: 429.35. | |
| Furagin | Furagin (a nitrofurantoin analog) has the same efficacy in treating acute cystitis as Ciprofloxacin, however the duration of therapy is longer. Antibacterial. Synonyms: NF 416; NF416; NF-416; F-35; Akritoin; Furazidin; Furazidine; Furagin. Grades: >98%. CAS No. 1672-88-4. Molecular formula: C10H8N4O5. Mole weight: 264.19. | |
| Fuzuloparib | Fuzuloparib is a poly (ADP-ribose) polymerase (PARP) inhibitor potentially for the treatment of solid tumours. Synonyms: 4-({4-fluoro-3-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carbonyl]phenyl}methyl)phthalazin-1(2H)-one; 1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-; Fuzuopali; SHR-3162; Fuzuloparibum. Grades: ≥98%. CAS No. 1358715-18-0. Molecular formula: C22H16F4N6O2. Mole weight: 472.40. | |
| FX1 | FX1 is a selective inhibitor of B cell lymphoma 6 (BCL6) (IC50 = 35 μM in reporter assays), which can disrupt formation of the BCL6 repression complex, reactivate BCL6 target genes and mimick the phenotype of mice engineered to express BCL6 with corepressor binding site mutations. FX1 also inhibits ABC-DLBCL cells. Synonyms: FX1; FX-1; FX 1. SCHEMBL16323186; CHEBI:133537; AKOS015865677; CS-7688; HY-102027; 3-[(5Z)-5-(5-chloro-2-oxo-1H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid. Grades: 99.75 %. CAS No. 1426138-42-2. Molecular formula: C14H9ClN2O4S2. Mole weight: 368.82. | |
| G007-LK | G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK was first discovered by Dr. Stefan Krauss's team. Synonyms: G007LK; G007LK; G007 LK. Grades: >98%. CAS No. 1380672-07-0. Molecular formula: C25H16ClN7O3S. Mole weight: 529.96. | |
| G 28UCM | G 28UCM is a fatty acid synthase inhibitor that potently inhibits the proliferation of breast cancer cell. G 28UCM blocks HER2 signaling, induces apoptosis, and suppresses growth of breast cancer xenografts in mice without causing anorexia. Synonyms: 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate; 1,3-Bis[(3,4,5-Trihydroxybenzoyl)Oxy]Naphthalene. Grades: ≥98% by HPLC. CAS No. 1094451-90-7. Molecular formula: C24H16O10. Mole weight: 464.38. | |
| G3335 | G3335 is a cell-permeable dipeptide that selectively and reversibly antagonizes PPARγ with a Kd value of 8.34 μM. G3335 reversiblyand competitively blocks activation of PPARγ by rosiglitazone. Synonyms: tryptophanyl-glutamic acid; Tryptophyl-Glutamate; L-Trp-L-Glu; L-tryptophyl-L-glutamic acid; N-L-Tryptophyl-L-glutamic acid; (S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-pentanedioic acid. Grades: ≥98%. CAS No. 36099-95-3. Molecular formula: C16H19N3O5. Mole weight: 333.34. | |
| G-749 | G-749 potently inhibits autophosphorylation of FLT3 with IC50 of ≤8 nM. In leukemia cells, G-749 shows antiproliferative activity by inducing apoptosis. Synonyms: G749; G-749; G 749. Grades: >98%. CAS No. 1457983-28-6. Molecular formula: C25H25BrN6O2. Mole weight: 521.41. | |
| Gabapentin hydrochloride | Gabapentin HCl is a GABA analogue.Originally it was developed to treat epilepsy, and is currently used to relieve neuropathic pain and restless leg syndrome. Synonyms: Gabapentin Hydrochloride; Gabapentin HCl; 60142-95-2; Gabapentin (hydrochloride); Gabarone; 1-(Aminomethyl)cyclohexaneacetic acid HCl; Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride; N0PY5N5AFW; 2-(1-(aminomethyl)cyclohexyl)acetic acid hydrochloride; 60142-95-2 (HCl); 2-[1-(aminomethyl)cyclohexyl]acetic acid hydrochloride; UNII-N0PY5N5AFW; 1-(Aminomethyl)cyclohexaneacetic acid hydrochloride; Neurontin HCl. Grades: >98%. CAS No. 60142-95-2. Molecular formula: C9H17NO2.HCl. Mole weight: 207.7. | |
| Gabexate mesylate | Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. Synonyms: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate; Gabexate; Gabexate mesylate; gabexate mesilate. Arodate; Megacart; Megacert; Mesyl Gabexate; Arodate. CAS No. 56974-61-9. Molecular formula: C17H27N3O7S. Mole weight: 417.48. | |
| Gaboxadol | Gaboxadol is a GABA agonist. It was a non-opioid analgesic and a novel type of hypnotic. It was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-Larsen. It is an experimental sleep aid drug developed by Lundbeck and Merck. It was used as an analgesic and anxiolytic, as well as a treatment for tardive dyskinesia, Huntington's disease, Alzheimer's disease, and spasticity. It was in clinic phase 3 trials, but now it was terminated. Uses: Gaboxadol was used as an analgesic and anxiolytic, as well as a treatment for tardive dyskinesia, huntington's disease, alzheimer's disease, and spasticity. Synonyms: OV-101;Lu-02-030;MK-0928;Lu-02030;MK0928;Lu02030;THIP;4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3(2H)-one;4,5,6,7-Tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-one. Grades: 98%. CAS No. 64603-91-4. Molecular formula: C6H8N2O2. Mole weight: 140.14. | |
| Gadolinium chloride | Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist that induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Gadolinium chloride blocks stretch-activated calcium channels, and disrupts the increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Gadolinium chloride also exhibits an inhibitory effect on TRPML channel currents and other TRP channels. Synonyms: Gadolinium trichloride; trichlorogadolinium. CAS No. 10138-52-0. Molecular formula: GdCl3. Mole weight: 263.61. | |
| GAL-021 | GAL-021 a novel intravenous BKCa-channel blocker potentially for the treatment of respiratory depression. Synonyms: 2-N-methoxy-2-N-methyl-4-N,6-N-dipropyl-1,3,5-triazine-2,4,6-triamine; GAL-021; GAL021. CAS No. 1380341-99-0. Molecular formula: C11H22N6O. Mole weight: 254.33. | |
| galacto-Dapagliflozin | Galacto-Dapagliflozin potently inhibits human SGLT2 (Ki = 2 nM) which is 1,000-fold less potent at human SGLT1 (Ki = 25,000). Synonyms: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-galactitol. Grades: ≥95%. CAS No. 1408245-02-2. Molecular formula: C21H25ClO6. Mole weight: 408.9. | |
| Galanthamine | Galanthamine, also called Razadyne, found in GALANTHUS and other AMARYLLIDACEAE, a cholinesterase inhibitor prescribed to treat symptoms of mild to moderate Alzheimer's, enhances cholinergic function accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. Uses: Treatment of alzheimer's disease. Synonyms: NSC 100058; NSC100058; NSC-100058; BRN 0093736; BRN0093736; BRN-0093736; Galantamine; Reminyl; Lycoremine; (-)-Galanthamine; Galantamin; Lycoremin; Jilkon; Nivalin; Razadyne; Galantamina; Galanthaminum; Galantaminum; Razadyne ER; Galantaminum. Grades: >98%. CAS No. 357-70-0. Molecular formula: C17H21NO3. Mole weight: 287.35. | |
| Galantide | Galantide, a neuropeptide, is a reversible and non-specific galanin receptor antagonist. Galantide showed a more than 10-fold higher affinity to the galanin receptors than did galanin. Galantide was not only the very high-affinity ligand at pancreatic and Rin m 5F cell galanin receptors but it also acted as the first galanin antagonist. Synonyms: Galanin (1-13)-Substance P (5-11) amide; H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparagyl-L-seryl-L-alanyl-glycyl-L-tyrosyl-L-leucyl-L-leucyl-glycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl-L-methioninamide. Grades: ≥95%. CAS No. 138579-66-5. Molecular formula: C104H151N25O26S. Mole weight: 2199.53. | |
| Gallamine Triethiodide | Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. It is is a non-depolarising muscle relaxant. Synonyms: Gallamine Triethiodide; Flaxedil; Tricuran; Gallamoni jodidum; Gallaminii iodidum; Triethyl Iodide, Gallamine; Iodide, Gallamine; Triethyl Iodide, Gallamonium; Gallamine Triethochloride. Grades: >98%. CAS No. 65-29-2. Molecular formula: C30H60I3N3O3. Mole weight: 891.53. | |
| Gallocyanine | Gallocyanine belongs to the oxazine class of dyes and is often used to stain animal cells, mostly the nucleic acids. Gallocyanine is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Synonyms: IIIC3; Alizarine Navy Blue; Anthracene Blue SWGG; Brilliant Chrome Blue P; C.I. 51030; Fast Violet; Mordant Blue 10; 7-Dimethylamino-4-hydroxy-3-oxo-phenoxazine-1-carboxylic acid. Grades: ≥95%. CAS No. 1562-85-2. Molecular formula: C15H13N2O5·Cl. Mole weight: 336.7. | |
| Gamabufotalin | Gamabufotalin is a major bufadienolide of Chansu and has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. Uses: Strong heart, antitumor. Synonyms: Gamabufagin. Grades: >98%. CAS No. 465-11-2. Molecular formula: C24H34O5. Mole weight: 402.52. | |
| γ1-MSH | γ1-MSH, a hormone derived from ACTH 1-13, is an endogenous melanocortin MC3 receptor agonist (pKi = 7.46) with ~ 40-fold selectivity over MC4. It stimulates melanogenesis and facilitates learning and memory, and can affect inflammatory and immune responses and peripheral nerve regeneration. Synonyms: TYR-VAL-MET-GLY-HIS-PHE-ARG-TRP-ASP-ARG-PHE-NH2; YVMGHFRWDRFG-NH2; MELANOCYTE STIMULATING HORMONE, GAMMA-1-HUMAN; GAMMA1-MELANOCYTE STIMULATING HORMONE; GAMMA-1-MELANOCYTE STIMULATING HORMONE, AMIDE; GAMMA1-MSH; GAMMA-1-MSH, AMIDE; GAMMA-1-MSN, HUMAN. CAS No. 72629-65-3. Molecular formula: C72H97N21O14S. Mole weight: 1512.76. | |
| γ-Linolenic acid ethyl ester | γ-Linolenic acid (GLA) is an ω-6 fatty acid that acts as a weak leukotriene B4 (LTB4) receptor antagonist. Synonyms: Gamma-Linolenic acid ethyl ester; GLA ethyl ester; Ethyl gamma-linolenate. Grades: ≥98%. CAS No. 31450-14-3. Molecular formula: C20H34O2. Mole weight: 306.5. | |
| γ-Linolenic acid methyl ester | γ-Linolenic acid (GLA) is an ω-6 fatty acid that acts as a weak leukotriene B4 (LTB4) receptor antagonist. Synonyms: Methyl GLA; Methyl γ-Linolenate; Methyl gamma-linolenate; Gamma-Linolenic acid methyl ester; Methyl (6Z,9Z,12Z)-octadeca-6,9,12-trienoate; Methyl (Z,Z,Z)-6,9,12-octadecatrienoate. Grades: ≥98%. CAS No. 16326-32-2. Molecular formula: C19H32O2. Mole weight: 292.5. | |
| gamma-secretase modulator 1 | gamma-secretase modulator 1 is a gamma-secretase modulator, useful for Alzheimer's disease. Synonyms: gamma-secretase modulator 1; 1172637-87-4; 4,5,6,7-Tetrahydro-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4-phenyl-2-benzothiazolamine; N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine; VFSGAZRYSCNFDF-UHFFFAOYSA-N; SCHEMBL1616912; CHEMBL1915569; DTXSID90655321; XWB63787; AKOS030526283; CS-0329; NCGC00378743-01; HY-10043; MS-27256; F83676; A908573; [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(4-phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine; N-[3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine. Grades: >98%. CAS No. 1172637-87-4. Molecular formula: C24H24N4OS. Mole weight: 416.54. | |
| gamma-secretase modulator 2 | gamma-secretase modulator 2, a triazole derivative, a potent and selective γ-secretase modulator so as to selectively attenuate production of Aβ(1-42) and hence has the potential for treatment of Alzheimer's disease. Synonyms: 6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one; gamma-secretase modulator 2; 1093978-89-2; SCHEMBL3040102; DTXSID70732149; C25H22F4N6O2; 3374AH; ABP000472; BCP9000905; CS-0310; HE070827; HE211077; HY-50754; DB-014988; W-5511; 2H-1-BENZAZEPIN-2-ONE,6-FLUORO-1,3,4,5-TETRAHYDRO-3-[4-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)PHENYL]-1H-1,2,3-TRIAZOL-1-YL]-1-(2,2,2-TRIFLUOROETHYL)-; 6-fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-Benzazepin-2-on; 6-Fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-benzazepin-2-one; 6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]-1h-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2h-1-benzazepin-2-one; 6-FLUORO-3-{4-[3-METHOXY-4-(4-METHYLIMIDAZOL-1-YL)PHENYL]-1,2,3-TRIAZOL-1-YL}-1-(2,2,2-TRIFLUOROETHYL)-4,5-DIHYDRO-3H-1-BENZAZEPIN-2-ONE. CAS No. 1093978-89-2. Molecular formula: C25H22F4N6O2. Mole weight: 514.47. | |
| gamma-secretase modulator 3 | gamma-secretase modulator 3 is a γ-secretase inhibitor. Synonyms: 4-(4-fluorophenyl)-N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine; gamma-secretase modulator 3; CS-1149; HY-50889; W-6019; CS 1149; HY 50889; W 6019; CS1149; HY50889; W6019; 1431697-84-5. CAS No. 1431697-84-5. Molecular formula: C24H23FN4OS. Mole weight: 434.53. | |
| gamma-Secretase modulators | gamma-Secretase Modulators is a potent modulator of γ-secretase derived from oxadiazine. (IC50: Aβ42 = 11 nM, Aβ total/ Aβ42 = 1170). Synonyms: (4R,7E,9aS)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one; gamma-Secretase Modulators; 937812-80-1; (E)-(4R,9aS)-7-[3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one; QCR-41; SCHEMBL2589995; DTXSID90647302; C26H24F3N3O3; hexahydro-7-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-4-(3,4,5-trifluorophenyl)-(4R,7E,9aS)-Pyrido[2,1-c][1,4]oxazin-6(1H)-one; 3690AH; ZINC95644683. CAS No. 937812-80-1. Molecular formula: C26H24F3N3O3. Mole weight: 483.48. | |
| Ganetespib | Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor STA-9090 binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional Hsp90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. Synonyms: STA-9090; STA 9090; STA9090. Grades: >98%. CAS No. 888216-25-9. Molecular formula: C20H20N4O3. Mole weight: 364.40. | |
| Ganstigmine hydrochloride | Ganstigmine hydrochloride is a selective inhibitor of AChE as a useful therapeutic drug for Alzheimer's disease patients with cognitive impairment accompanied by depression. Uses: Ache inhibitor. Synonyms: CHF 2819; CHF2819; CHF-2819; Ganstigmine hydrochloride; Ganstigmine HCl. Carbamic acid, (2-ethylphenyl)-, (1R,3aS,8aS)-1,2,3,3a,8,8a-hexahydro-1,3a-dimethyl-1-oxidopyrrolo(2,3-b)indol-5-yl ester, monohydrochloride;[(3R,3aS,8bS)-3,8b-dimethyl-3-oxido-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-(2-ethylphenyl)carbamate;hydrochloride. Grades: ≥98%. CAS No. 412044-92-9. Molecular formula: C21H26ClN3O3. Mole weight: 403.9. | |
| Garenoxacin | Garenoxacin, also called as BMS 284756, a new desfluoro(6)quinolone, is a topoisomerase II inhibitor with actibacterial activity to treat Gram-positive and Gram-negative bacterial infections. Uses: Des-f(6)-quinolone antibacterial; topoisomerase ii inhibitor. antibacterial. Synonyms: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid BMS 284756 BMS-284756 BMS284756 garenoxacin. CAS No. 194804-75-6. Molecular formula: C23H20F2N2O4. Mole weight: 426.41. | |
| Garenoxacin mesylate | Garenoxacin mesylate is a novel oral des-fluoro quinolone with potent antimicrobial activity for the treatment of Gram-positive and Gram-negative bacterial infections. Synonyms: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid; 1-cyclopropyl-8-(difluoromethoxy)-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate; T 3811ME; BMS 284756; BM-284756; BMS284756; T-3811ME; T3811ME. Grades: >98%. CAS No. 223652-82-2. Molecular formula: C24H24F2N2O7S. Mole weight: 522.52. | |
| Garenoxacin Mesylate hydrate | Garenoxacin Mesylate hydrate is the Mesylate hydrate salt form of Garenoxacin. Garenoxacin, also called as BMS 284756, a new desfluoro(6)quinolone, is a topoisomerase II inhibitor with actibacterial activity to treat Gram-positive and Gram-negative bacter. Synonyms: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid;hydrate BMS 284756 BMS-284756 BMS284756 garenoxacin. CAS No. 223652-90-2. Molecular formula: C24H26F2N2O8S. Mole weight: 540.53. | |
| Garomefrine hydrochloride | Garomefrine hydrochloride is a Alpha 1A adrenergic receptor agonist under the development of Nippon Shinyaku. Phase II clinical trials for the treatment of Stress incontinence and Urinary incontinence was discontinued in USD in 2001. Uses: Stress incontinence; urinary incontinence. Synonyms: NS 49;ABT 232; PNO 49B;((R)-(-)-3'-(2-Amino-1-hydroxyethyl)-4'-fluoro-methanesulfonanilide hydrochloride. Grades: 98%. CAS No. 137431-04-0. Molecular formula: C9H14ClFN2O3S. Mole weight: 284.74. | |
| Gartisertib | Gartisertib is an orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival. Synonyms: ATR inhibitor 2; VX-803 (M4344); M-4344; 2-Amino-6-fluoro-N-[5-fluoro-4-(4-{[4-(3-oxetanyl)-1-piperazinyl]carbonyl}-1-piperidinyl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide. Grades: ≥95%. CAS No. 1613191-99-3. Molecular formula: C25H29F2N9O3. Mole weight: 541.55. | |
| Gastric Inhibitory Peptide (human) trifluoroacetate salt | Gastric inhibitory peptide (GIP) is a biologically active 42-amino acid peptide and it acts as a GIP receptor agonist that binds to rat recombinant GIP receptors expressed in CHO-K1 cells (IC50 = 3.2 nM) and increases cAMP accumulation (EC50 = 377 pM). Synonyms: GIP (human); Glucose-dependent Insulinotropic Peptide (human). Grades: ≥95%. Molecular formula: C226H338N60O66S·xCF3COOH. Mole weight: 4983.53. | |
| Gastrin/CCK antagonist 1 | An antagonist of gastrin/CCK. Synonyms: Urea, N-[1-cyclohexyl-2,3,4,5-tetrahydro-2,4-dioxo-5-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-1,5-benzodiazepin-3-yl]-N'-(4-fluorophenyl)-. CAS No. 162271-52-5. Molecular formula: C28H32FN5O4. Mole weight: 521.58. | |
| GAT107 | GAT107 is an allosteric agonist (EC50 value 28 μM) and positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors (nAChR). GAT107 is the bioactive enantiomer of 4BP-TQS. It reverses nociception in mouse models of inflammatory and neuropathic pain. Synonyms: GAT107; GAT-107; GAT 107; (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide. Grades: 99%. CAS No. 1476807-74-5. Molecular formula: C18H17BrN2O2S. Mole weight: 405.31. | |
| GAT211 | GAT211 is a positive allosteric modulator (PAM) and acts as a selective inhibitor of cannabinoid receptor 1 (CB1). It is a racemic mixture of GAT228 and GAT229. Uses: Cannabinoid receptor agonists. Synonyms: 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole. Grades: ≥98%. CAS No. 102704-40-5. Molecular formula: C22H18N2O2. Mole weight: 342.39. | |
| GAT228 | GAT228 is the R-(+)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT229 and a component of the racemic mixture GAT211. GAT228 is an allosteric agonist of cannabinoid receptor 1 (CB1). Synonyms: 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole. Grades: ≥98%. CAS No. 1446648-15-2. Molecular formula: C22H18N2O2. Mole weight: 342.39. | |
| GAT229 | GAT229 is the S-(-)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT228 and a component of the racemic mixture GAT211. GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) which can't activate the receptor on its own but enhances the binding and activity of CB agonists. Uses: Cannabinoid receptor agonists. Synonyms: 3-[(1S)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole; S-(-)-3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole. Grades: ≥98%. CAS No. 889860-85-9. Molecular formula: C22H18N2O2. Mole weight: 342.39. | |
| Gatifloxacin hydrochloride | Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Synonyms: Gatifloxacin hydrochloride. Grades: >98%. CAS No. 121577-32-0. Molecular formula: C19H23ClFN3O4. Mole weight: 411.86. | |
| Gavestinel | Gavestinel is a non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), displaying >1000-fold selectivity over NMDA, AMPA, and kainate binding sites. Gavestinel exhibits a neuroprotective property in animal models of ischaemic stroke. Uses: Glycine agents. Synonyms: 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, (E)-; 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-1H-indole-2-carboxylic acid; GV 150526; GV 150526X; (E)-4,6-dichloro-3-(3-oxo-3-(phenylamino)prop-1-en-1-yl)-1H-indole-2-carboxylic acid. Grades: ≥95%. CAS No. 153436-22-7. Molecular formula: C18H12Cl2N2O3. Mole weight: 375.21. | |
| GB 83 | GB 83 is a selective antagonist of human protease activated receptor 2 (PAR2) (IC50 = 2 mM). Synonyms: GB83; GB 83; GB-83; N-((S)-3-Cyclohexyl-1-((2S,3S)-1-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)-3-methyl-1-oxopentan-2-ylamino)-1-oxopropan-2-yl)isoxazole-5-carboxamide. Grades: 99%. CAS No. 1252806-86-2. Molecular formula: C32H44N4O4. Mole weight: 548.72. | |
| GDC-0068 dihydrochloride | Testing against a broad panel of 230 kinases, GDC-0068 only inhibits 3 kinases by >70% at 1 μM concentration (PRKG1α, PRKG1β, and p70S6K, with IC50 of 98 nM, 69 nM, and 860 nM, respectively). GDC-0068 displays >100-fold selectivity for Akt over PKA with IC50 of 3.1 μM. In LNCaP, PC3 and BT474M1 cells, GDC-0068 treatment inhibits the phosphorylation of the Akt substrate, PRAS40 with IC50 of 157 nM, 197 nM, and 208 nM, respectively. Furthermore, GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by Akt signaling, including those with defects in the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2, with strongest effects in HER2+ and Luminal subtypes. Oral administration of GDC-0068 in PC3 prostate tumor xenografts model induces down-regulation of p-PRAS40. In BT474-Tr xenografts, GDC-0068 treatment reduces pS6 and peIF4G levels, re-localizes FOXO3a to nucleus, and induces feedback upregulation of HER3 and pERK. Administration of GDC-0068 exhibits potent antitumor efficacy in multiple xenograft tumor models, including the PTEN-deficient prostate cancer models LNCaP and PC3, the PIK3CA H1047R mutant breast cancer model KPL-4, and MCF7-neo/HER2 tumor model. Synonyms: Ipatasertib dihydrochloride; RG-7440 dihydrochloride; GDC-0068 dihydrochloride; RG 7440 dihydrochloride; GDC 0068 dihydrochloride; RG7440 dihydrochloride; GDC0068 dihydrochloride. Grades: >98%. CAS No. 1396257-94-5. Molecular formula: C24H34Cl3N5O2. Mole weight: 530.92. | |
| GDC-0326 | GDC-0326 is a selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor. GDC-0326 is highly selective over other kinases. It has low plasma CL in human. In PI3 kinase family, there are four class I PI3K isoforms including α, β, δ, and γ and PI3Kα is the most commonly associated with cancers, so GDC-0326 may become a drug candidate for cancer treatment. Uses: Anti-cancer. Synonyms: GDC-0326; GDC 0326; GDC0326; (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide. Grades: 98%. CAS No. 1282514-88-8. Molecular formula: C19H22N6O3. Mole weight: 382.42. | |
| GDC-0349 | GDC-0349 is a small molecule anticaner drug candidate, being developed by Genentech. As of July 2012, Genentech has filed phase I trial of GDC-0349 for evaluating the Safety and Tolerability of GDC-0349 in Patients With Locally Advanced or Metastatic Solid Tumors or Non Hodgkin's Lymphoma. Synonyms: GDC-0349; GDC 0349; GDC0349; RG7603. CAS No. 1207360-89-1. Molecular formula: C24H32N6O3. Mole weight: 452.559. | |
| GDC-0425 | This active molecular is an selective Checkpoint kinase 1 (Chk1) inhibitors and it enhances gemcitabine efficacy in tumor xenograft models. GDC-0425 was safe and yielded responses in patients with a variety of cancers. In Oct 2013, GDC 0425 was in phase I trials for Solid tumours and Lymphoma (late-stage disease) in USA and France. In May 2014, Genentech completed a phase I trial in Lymphoma and Solid tumours (late-stage disease) in USA and France. Uses: Solid tumours and lymphoma. Synonyms: GDC-0425; GDC 0425; GDC0425; 5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile;RG-7602; RG 7602; RG7602. Grades: 98%. CAS No. 1200129-48-1. Molecular formula: C18H19N5O. Mole weight: 321.38. | |
| GDC-0575 | GDC-0575 is a highly-selective, potent and oral small-molecule Chk1 inhibitor (IC50 = 1.2?nM). Uses: Protein kinase inhibitors. Synonyms: ARRY-575; RG7741; GDC0575. Grades: ≥98%. CAS No. 1196541-47-5. Molecular formula: C16H20BrN5O. Mole weight: 378.27. | |
| GDC-0623 | GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868. CAS No. 1168091-68-6. Molecular formula: C16H14FIN4O3. Mole weight: 456.216. | |
| GDC-0810 (ARN-810) | GDC-0810, also known as ARN-810 and RG6046, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. Synonyms: GDC0810; GDC 0810; GDC-0810; ARN810; ARN 810; ARN-810; RG6046; RG-6046; RG 6046. Grades: 98%. CAS No. 1365888-06-7. Molecular formula: C26H20ClFN2O2. Mole weight: 446.91. | |
| GDC-0834 | GDC-0834 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. In vitro metabolite identification studies in hepatocytes revealed predominant formation of an inactive metabolite (M1) via amide hydrolysis in human. Synonyms: GDC-0834; GDC0834; GDC 0834. CAS No. 1133432-46-8. Molecular formula: C33H36N6O3S. Mole weight: 596.74. | |
| GDC-0837 | GDC-0834 is a small molecule inhibitor of Btk potentially useful in the treatment of RA and lymphoid malignancies. Administration of GDC-0834 (30 -- 100 mg/kg) in a rat CIA model induced a decrease of ankle swelling and reduction of morphologic pathology in a dose-dependent manner. Synonyms: GDC-0837; GDC 0837; GDC0837. CAS No. 1133432-49-1. Molecular formula: C33H36N6O3S. Mole weight: 596.74. | |
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