BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| EBPC | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy (hydroxy)methylidene]pyrrolidine-2, 3-dione. Grades: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. |  |
| Ebrotidine | Ebrotidine(FI 3542), a competitive H2-receptor antagonist, has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. IC50: 127.5 nM (Ki)[1]; 0.21mg/kg (ED50, histamine- stimulated acid secretion). It also. Uses: Ebrotidine(fi 3542) is a competitive h2-receptor antagonist and has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. Synonyms: FI-3542; FI 3542; FI3542; Ebrotidine. Grades: 95%. CAS No. 100981-43-9. Molecular formula: C14H17BrN6O2S3. Mole weight: 477.43. | |
| EC 144 | EC 114 is a high affinity, potent and selective Hsp90 inhibitor. IC50 1.1 nM. It exhibits selectivity for Hsp90 over Grp94 and TRAP1 (Ki values are 61 and 255 nM respectively) and has no effect (IC50 > 10μM) against a panel of 285 kinases. Degrades Her-2 in MCF-7 breast cancer cells (EC50 = 14 nM). Blocks tumor growth and induces partial tumor regression in an N87 gastric tumor mouse model. Also inhibits LPS-induced TNFα release in an LPS shock mouse model and suppresses disease development in a rat model of collagen-induced arthritis. Exhibits < 20-fold efficacy over BIIB 021 in mice. Orally available and brain penetrant. Synonyms: EC144; EC-144; EC 144; Alkyne 40; Alkyne-40; Alkyne40. Grades:>98%. CAS No. 911397-80-3. Molecular formula: C21H24ClN5O2. Mole weight: 413.90. | |
| Ec2la | Ec2la is a positive allosteric modulator of CB2 receptor. It enhances CP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2 receptors, but doesn't have effect in the absence of agonist. Synonyms: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide. Grades: ≥98% by HPLC. CAS No. 2244579-87-9. Molecular formula: C21H24BrFN2O2. Mole weight: 435.33. | |
| Ecabet sodium | Ecabet sodium is a Prostaglandin agonist under the development of Mitsubishi Tanabe Pharma Corporation. Now ecabet sodium is marketed in Japan a for treatment of gastric ulcers and gastritis. Uses: Gastric ulcer; gastritis. Synonyms: 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt;Sulfodehydroabietic acid monosodium salt. Grades: 98%. CAS No. 86408-72-2. Molecular formula: C20H27NaO5S. Mole weight: 402.48. | |
| eCF309 | eCF309 is a potent and cell-permeable inhibitor of mTOR signaling (IC50 value 10 - 15 nM in vitro and in vivo) that exhibits >60-fold selectivity over PI3Ks. It is used as a highly valuable probe for chemical biology and biomedicine for its more potent activity compared to other mTOR inhibitors. Uses: Antitumor agent. Synonyms: 5-[4-amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine; ECF 309; ECF-309; GTPL9571. Grades: 98%. CAS No. 2001571-40-8. Molecular formula: C18H21N7O3. Mole weight: 383.4. | |
| eCF506 | eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentration (IC50 < 0.5 nM). It is said that eCF506 is the first drug candidate of a second generation of Src inhibitors that will not only help to understand the complexity of some cancers but also the development of safer combination therapies. Synonyms: eCF506; eCF-506; eCF 506.; tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate; eCF506; Derivative 11a; GTPL9186; derivative 11a [PMID: 27115835]; tert-butyl N-[4-(4-amino-1-{2-[4-(dimethylamino)piperidin-1-yl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate. Grades:>98%. CAS No. 1914078-41-3. Molecular formula: C26H38N8O3. Mole weight: 510.643. | |
| Ecopipam | Ecopipam, a synthetic benzazepine derivative drug, acts as a selective dopamine D1/D5 receptor antagonist with little affinity for either dopamine D2-like or 5-HT2 receptors. It was developed by Schering plough. It is currently in clinical trials conducted by the biotechnology company Psyadon Pharmaceuticals for the treatment of Tourette syndrome in children. It has received FDA treatment of Lesch-Nyhan disease orphan drug certification. Uses: Ecopipam was used for the treatment of tourette syndrome in children. Synonyms: Sch 39166;(6aS)-11-Chloro-6,6aβ,7,8,9,13bα-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol;(6aβ,13bα)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol;5H-Benzo(D)naphth(2,1-B)azepin-12-ol, 11-chloro-6,6A,7,8,9,13B-hexahydro-7-methyl-, trans-(-)-;6, 7, 7A, 8, 9, 13B-Hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo(D)naphtho(2, 1B)azepine;(6aS, 13bR)-11-chloro-7-methyl-5, 6, 6a, 8, 9, 13b-hexahydronaphtho[1, 2-a][3]benzazepin-12-ol;5H-Benzo(d)naphth(2, 1-b)azepin-12-ol, 11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-, (6aS,13bR)-. Grades: >98%. CAS No. 112108-01-7. Molecular formula: C19H20ClNO. Mole weight: 313.83. | |
| Eculizumab | Eculizumab is a recombinant human IgG2/4κ monoclonal antibody used for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Eculizumab acts as a terminal complement inhibitor that binds to the terminal complement component 5, or C5 and suppresses the complement cascade. Uses: The treatment of pnh and ahus. Synonyms: Soliris. CAS No. 219685-50-4. | |
| Edaglitazone | Edaglitazone is a potent and selective PPARγ agonist (EC50 = 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively). Edaglitazone enhances insulin sensitivity in obese and can be a potential treatment of type 2 diabetes. Uses: Potential treatment of type 2 diabetes. Synonyms: Edaglitazone; Edaglitazone sodium; R-483; RO-2052349-602; BM-13.1258; RO-2052349-000; Ro-205-2349. 5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione; BM 131258; R 483. Grades: ≥98% by HPLC. CAS No. 213411-83-7. Molecular formula: C24H20N2O4S2. Mole weight: 464.56. | |
| Edasalonexent | Edasalonexent, also known as CAT-1004, is a NF-kappa B inhibitor under the development of Catabasis Pharmaceuticals and Sarepta Therapeutics. It is a Inflammation mediator inhibitor and could be an anti-inflammatory drug candidate. In Apr 2016, Phase-II clinical trials in Duchenne muscular dystrophy (In children) in USA were on-going. In Sep 2016, Catabasis Pharmaceuticals and Sarepta Therapeutics agreed to co-develop edasalonexent with an exon skipping treatment together in USA for Duchenne muscular dystrophy. Uses: Anti-inflammatory; duchenne muscular dystrophy. Synonyms: CAT-1004; CAT1004; CAT 1004; Edasalonexent; Sodium salicylate-docosahexaenoic acid conjugate;N-(2-((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamido)ethyl)-2-hydroxybenzamide. Grades: 98%. CAS No. 1204317-86-1. Molecular formula: C31H42N2O3. Mole weight: 490.69. | |
| Edelfosine | Edelfosine, an orally administered antileishmanial drug, has anti-metastasis effect in experimental tumors. Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. Uses: Phosphodiesterase inhibitors. Synonyms: ALP; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-OMe; ET 18-OCH3; rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine; NSC-324368; (±)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium hydroxide inner salt 4-oxide. Grades: ≥95%. CAS No. 70641-51-9. Molecular formula: C27H58NO6P. Mole weight: 523.73. | |
| Edonentan | Edonentan, also known as BMS-207940, is a very potent and selective ETA endothelin receptor antagonist (Ki= 10 pM) that shows 80000-fold selective for ETA vs ETB. Synonyms: BMS-207940; BMS207940; BMS 207940; Edonentan; N-[[2-[2-[(4,5-dimethyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-N,3,3-trimethylbutanamide; Edonentan; UNII-S5016F5ZH4 ;CHEMBL383581; 210891-04-6; UNII-2CCC8CH216; Edonentan[INN]; 210891-04-6 (Edonentan); 264609-13-4 (Edonentan hydrate). Grades: 95%. CAS No. 210891-04-6. Molecular formula: C28H32N4O5S. Mole weight: 536.64. | |
| EDO-S101 | EDO-S101 is a pan HDAC inhibitor (IC50 = 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3, respectively). EDO-S101 is a first-in-class fusion molecule that combines DNA damaging effect of bendamustine with the pan-HDACi vorinostat. Synonyms: 7-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]-N-hydroxyheptanamide; EDO-S101; EDO-S 101; EDO-S-101; EDO-S101 HCl; EDO-S101 hydrochloride; Tinostamustine hydrochloride. CAS No. 1236199-60-2. Molecular formula: C19H28Cl2N4O2. Mole weight: 415.36. | |
| Edoxaban | Edoxaban is an oral factor Xa (FXa) inhibitor, also contraindicated in patients with active pathological bleeding. Uses: A direct factor xa inhibitor. Synonyms: DU-176; DU 176; DU176DU-176b;N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide. Grades: ≥98%. CAS No. 480449-70-5. Molecular formula: C24H30CLN7O4S. Mole weight: 548.06. | |
| Edoxaban TsOH salt | Edoxaban is an oral factor Xa (FXa) inhibitor, also contraindicated in patients with active pathological bleeding. Uses: A direct factor xa inhibitor. Synonyms: Edoxaban Tosylate; N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide;4-methylbenzenesulfonic acid. Grades: ≥98%. CAS No. 480449-71-6. Molecular formula: C31H38ClN7O7S2. Mole weight: 720.26. | |
| Edrophonium | Edrophonium is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of disease. Uses: Edrophonium is a reversible acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of disease. Synonyms: N-Ethyl-3-hydroxy-N,N-dimethyl-benzenaminium Chloride. Grades: > 95%. CAS No. 312-48-1. Molecular formula: C10H16NO+. Mole weight: 166.24. | |
| Edrophonium chloride | Edrophonium chloride is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts o. Uses: Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively so that could be commonly used in the diagnosis of myasthenia gravis and other sorts of diseases. Synonyms: ETHYL[M-HYDROXYPHENYL]-DIMETHYLAMMONIUM CHLORIDE;EDROPHONIUM CHLORIDE; antirex; dimethylethyl(m-hydroxyphenyl)-ammoniuchloride; ethyl(m-hydroxyphenyl)dimethyl-ammoniuchloride; n-ethyl-3-hydroxy-n, n-dimethyl-benzenaminiuchloride; tensilon; ethyl(3-hydroxyphenyl. Grades: ≥99%. CAS No. 116-38-1. Molecular formula: C10H16NOCl. Mole weight: 201.69. | |
| Efaroxan hydrochloride | Efaroxan hydrochloride is a potent and selective α2 adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi = 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A, α2B, α2C, I1, and I2 receptors, respectively). Efaroxan promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3 receptor) in vitro and in vivo. Synonyms: Efaroxan HCl; RX 821037A; RX821037A; RX-821037A; EU-0100521; EU0100521; EU 0100521; 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride. Grades: ≥99% by HPLC. CAS No. 89197-00-2. Molecular formula: C13H16N2O.HCl. Mole weight: 252.74. | |
| (E)-FeCP-oxindole | (E)-FeCP-oxindole is a human vascular endothelial cell growth factor receptor 2 (VEGFR-2) inhibitor (IC50 = 214 nM). (E)-FeCP-oxindole exhibits anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Synonyms: (E)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one. CAS No. 884338-18-5. Molecular formula: C19H15FeNO. Mole weight: 329.17. | |
| EFONIDIPINE | Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. It could also present as the hydrochloride salt form. Uses: Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of t-type and l-type calcium channels. Synonyms: NZ-105; NZ 105; NZ105; Efonidipine; Efonidipine[INN]; 111011-63-3; C34H38N3O7P; Efonidipine(INN); Landel. Grades: 95%. CAS No. 111011-63-3. Molecular formula: C34H38N3O7P. Mole weight: 631.66. | |
| EFONIDIPINE HCL | The hydrochloride salt form of Efonidipine which could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. Uses: The hydrochloride salt form of efonidipine which could be effective in the treatment of cardiovascular disease as a blocker of t-type and l-type calcium channels. Synonyms: EFONIDIPINE HCL;Efonidipine hydrochloride. Grades: 95%. CAS No. 111011-53-1. Molecular formula: C34H38N3O7P.HCl. Mole weight: 668.12. | |
| Efonidipine hydrochloride monoethanolate | The hydrochloride monoethanolate salt form of Efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders. Uses: The hydrochloride monoethanolate salt form of efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders. Synonyms: Efonidipine hydrochloride ethanol; Efonidipine hydrochloride ethanolate; NZ 105 ethanolate; NZ105 ethanolate; NZ-105 ethanolate; EFONIDIPINE HYDROCHLORIDE MONOETHANOLATE; 111011-76-8; Efonidipine.HCl ethanolate. Grades: >98%. CAS No. 111011-76-8. Molecular formula: C36H45ClN3O8P. Mole weight: 631.66. | |
| EG 00229 Trifluoroacetate | EG00229 is a small molecule inhibitor of neuropilin-1(Nrp1) with an IC50 of 3μM. EG00229 has been reported to inhibit VEGF-A binding to PAE/NRP1 in the Nrp1and bt-VEGF-A binding to purified Nrp1 b1 domain in a cell-free assay with an IC50 value of 8μM and 3μM, respectively. In addition, EG00229 has also shown the inhibition of VEGF-A binding to VEGFR2, VEGFR1 and Nrp1 in human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner with an IC50 value of 23μM [1]. Besides, EG00229 has been revealed to prevent tuftsin binding to the Nrp1 which is at the cell surface. Moreover, EG00229 has been noted to suppress the anti-inflammatory M2 shift in microglia induced by tuftsin and thus potently prevent tuftsin's action. Synonyms: EG 00229; EG-00229. Grades: >98%. CAS No. 1210945-69-9. Molecular formula: C19H20F3N7O7S3. Mole weight: 611.6. | |
| Eg5-I | Eg5, also known as KSP and Kif11, is a kinesin-like spindle protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). Synonyms: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol. Grades: ≥98%. CAS No. 1338701-15-7. Molecular formula: C23H25NO2S. Mole weight: 379.5. | |
| EGF816 mesylate | EGF816 mesylate is the mesylate salt of EGF816 which is a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M. Synonyms: N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide;methanesulfonic acid. CAS No. 1508250-72-3. Molecular formula: C27H35ClN6O5S. Mole weight: 591.12. | |
| EGFR/ErbB2 Inhibitor | EGFR/ErbB2 inhibitor is a cell-permeable 4-anilino quinazoline compound, which is a potent and reversible inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively). It inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 μM). Synonyms: 4557W; 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline; EGFR/ErbB-2 Inhibitor. Grades: ≥95%. CAS No. 179248-61-4. Molecular formula: C23H21N3O3. Mole weight: 387.4. | |
| EGFR-IN-2 | EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. It showed excellent cellular activity against both the single and double mutants of EGFR, demonstrating target engagement in vivo and ADME-PK properties that are suitable for further evaluation. CAS No. 1643497-70-4. Molecular formula: C26H33N9O3S. Mole weight: 551.66. | |
| EGFR Inhibitor | A cell-permeable and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nanomolar range. Inhibition of EGFR induces apoptosis of tumor cells by ownregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim. Uses: Antitumor agent. Synonyms: EGFR inhibitor; EGFR-inhibitor; EGFRinhibitor; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; N- (3- ( (6- ( (3- (Trifluoromethyl) phenyl) amino) pyrimidin-4-yl) amino) phenyl) cyclopropanecarboxamide; K00598a. Grades: 99%. CAS No. 879127-07-8. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| EGIS-8332 | EGIS-8332 potently decreased AMPA and quisqualate induced LDH release (IC50 = 5.2 ± 0.4 and 7.4 ± 1.3 μM, respectively) from the cells. The inhibition of the AMPA/kainate ion channels by EGIS-8332 is non-competitive, not use dependent, and depends neither on the closed/open state of the channel, nor the membrane potential. Synonyms: 7-acetyl-5-(4-aminophenyl)-8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-8-carbonitrile; EGIS-8332; EGIS 8332; EGIS8332. Grades: >98%. CAS No. 220725-87-1. Molecular formula: C20H18N4O3. Mole weight: 362.389. | |
| EGLU | EGLU is a group II mGluR antagonist and also a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord. Synonyms: (2S)-α-Ethylglutamic acid; (2S)-2-amino-2-ethylpentanedioic acid. Grades: ≥95% by HPLC. CAS No. 170984-72-2. Molecular formula: C7H13NO4. Mole weight: 175.18. | |
| EGT1442 | EGT1442 is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively. It significantly prolonged the median survival of SHRSP rats. It attenuates blood glucose and HbA(1c) levels and prolongs the survival of stroke-prone rats in db/db mice. It showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients. It was developed by Theracos and in clinic phase 1 trials. Uses: Egt1442 showed favorable properties and could be beneficial to the management of type 2 diabetic patients. Synonyms: THR1442; THR-1442; THR 1442; EGT1442; EGT-1442; EGT 1442; Bexagliflozin; (1S) -1, 5-Anhydro-1-C-[4-chloro-3-[[4-[2- (cyclopropyloxy) ethoxy]phenyl]methyl]phenyl]-D-glucitol; Bexagliflozin; THR1442; EGT0001442; EGT-1442; THR-1442; EGT-0001442; (2S, 4R, 6R) -2- (4-chloro-3- (4- (2-cyclopropoxyethoxy) benzyl) phenyl) -6- (hydroxymethyl) tetrahydro-2H-pyran-3, 4, 5-triol; (3R, 4R, 5S, 6R) -2- (4-chloro-3- (4- (2-cyclopropoxyethoxy) benzyl) phenyl) -6- (hydroxymethyl) tetrahydro-2H-pyran-3, 4, 5-triol. Grades: >98%. CAS No. 1118567-05-7. Molecular formula: C24H29ClO7. Mole weight: 464.94. | |
| (±)-E-Homocamptothecin | (±)-E-Homocamptothecin is a potent topoisomerase I (Topo 1) inhibitor. Synonyms: (+/-)-E-Homocamptothecin; BN-80245; BN 80245; BN80245; E-Homocamptothecin, (+/-)-. Grades: 99%. CAS No. 186668-40-6. Molecular formula: C21H18N2O4. Mole weight: 362.38. | |
| EHT-6706 dihydrochloride | EHT-6706 can target the colchicine-binding site to inhibit tubulin polymerization as a tubulin polymerisation inhibitor. It is under the development of Diaxonhit. EHT 6706 also is a vascular-disrupting agent. It can prevent endothelial cell tube formation and disrupt pre-established vessels, change the permeability of endothelial cell monolayers and inhibit endothelial cell migration. In Jul 2013, preclincal development for treatment of cancer was ongoing in the USA. Uses: Cancer. Synonyms: EHT-6706 dihydrochloride; EHT 6706 dihydrochloride; EHT6706 dihydrochloride; 7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine dihydrochloride. Grades: 98%. CAS No. 1351592-09-0. Molecular formula: C21H26Cl2N2O4. Mole weight: 441.35. | |
| EI1 | EI1 inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. Synonyms: EI1; ei-1; KB-145943; 6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide; 6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide; 6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide; 6-cyano-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-1-(pentan-3-yl)-1H-indole-4-carboxamide; 6-cyano-n-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-1-(1-ethylpropyl)-1h-indole-4-carboxamide; EI1; Ezh2 inhibitor; Ezh2 inhibitor; EI-1; EI 1; GTPL7013; SCHEMBL16197843; DTXSID101111134; BCP23699; EX-A2431; s7611; AKOS030526508; CCG-268533; CS-1654; SB19343; NCGC00351776-01; NCGC00351776-03; AC-36069; AS-55788; HY-15573; C72647; A911213; Q27077166. Grades: >98%. CAS No. 1418308-27-6. Molecular formula: C23H26N4O2. Mole weight: 390.48. | |
| Eicosatetraynoic Acid | ETYA is a nonspecific and cell permeable inhibitor of cyclooxygenases and lipoxygenases. ETYA inhibits phospholipase A2 (PLA2), cytochrome P-450, cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase in whole cells. Synonyms: ETYA; 5,8,11,14-eicosatetraynoic acid; Octadehydroarachidonic acid. Grades: ≥98%. CAS No. 1191-85-1. Molecular formula: C20H24O2. Mole weight: 296.4. | |
| EIT hydrobromide | EIT hydrobromide is a potent and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively). Uses: Enzyme inhibitors. Synonyms: (S)-Ethylisothiourea hydrobromide; 2-Ethyl-2-thiopseudourea hydrobromide; Ethiron bromide. CAS No. 1071-37-0. Molecular formula: C3H8N2S.HBr. Mole weight: 185.08. | |
| ELA-11 (human) | ELA-11 (human) is a high affinity apelin receptor agonist (Ki = 14 nM). It is a bioactive fragment of ELA-32. ELA-11 (human) inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. Synonyms: Elabela/Toddler-11; 1784687-32-6; ELA-11; GTPL8526; CHEMBL3809035; BDBM50172365. Grades: ≥95%. CAS No. 1784687-32-6. Molecular formula: C58H90N16O13S2. Mole weight: 1283.57. | |
| ELA-21 (human) | ELA-21 (human) is a high affinity apelin receptor agonist that binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). It is a bioactive fragment of ELA-32. Grades: ≥98%. Molecular formula: C112H184N40O25S3. Mole weight: 2587.12. | |
| Elacestrant | Elacestrant, also referred to RAD1901, is a selective and orally available estrogen receptor (ERR) degrader (IC50= 48 and 870 nM for ERα and ERβ, respectively) and selective estrogen receptor modulator (SERM). Synonyms: RAD1901; RAD-1901; RAD 1901. CAS No. 722533-56-4. Molecular formula: C30H38N2O2. Mole weight: 458.65. | |
| Elacestrant S enantiomer | Elacestrant S enantiomer is a low activity enantiomer of Elacestrant, which is a selective and orally bioavailable small-molecule SERD (IC50s = 48 and 870 nM for ERα and ERβ, respectively). Synonyms: RAD1901 S enantiomer; 2-Naphthalenol, 6-[2-[ethyl[[4-[2- (ethylamino) ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5, 6, 7, 8-tetrahydro-, (6S)-; (6S)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol. CAS No. 2309762-29-4. Molecular formula: C30H38N2O2. Mole weight: 458.63. | |
| Elacestrant S enantiomer dihydrochloride | Elacestrant S enantiomer dihydrochloride is a low activity enantiomer of Elacestrant, which is a selective and orally bioavailable small-molecule SERD (IC50s = 48 and 870 nM for ERα and ERβ, respectively). Synonyms: RAD1901 S enantiomer dihydrochloride; (6S)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol dihydrochloride; 2-Naphthalenol, 6-[2-[ethyl[[4-[2- (ethylamino) ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5, 6, 7, 8-tetrahydro-, (6S)-, hydrochloride (1:2). Grades: ≥95%. CAS No. 2309762-30-7. Molecular formula: C30H40Cl2N2O2. Mole weight: 531.56. | |
| Elaidamide | Elaidamide has been found in the cerebrospinal fluid of sleep-deprived cats. Elaidamide is a fatty acid amide that inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM) and porcine pancreatic and human synovial phospholipase A2 (PLA2). Uses: Food additives. Synonyms: Elaidoylamide; (E)-9,10-Octadecenamide; 9E-octadecenamide. Grades: ≥95%. CAS No. 4303-70-2. Molecular formula: C18H35NO. Mole weight: 281.5. | |
| Elastatinal | Elastatinal is a potent and irreversible inhibitor of pancreatic elastase. It is a much stronger inhibitor of pancreatic elastase than the leukocyte-derived enzyme. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands. Synonyms: (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxyethyl]-L-glutamamide. Grades: ≥ 95 %. CAS No. 51798-45-9. Molecular formula: C21H36N8O7. Mole weight: 512.56. | |
| Elenbecestat | Elenbecestat is a novel, potent and orally bioavailable BACE1 inhibitor for the treatment of Alzheimer's disease (AD), which demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing. Synonyms: E2609; N-[3-[(4aS,5R,7aS)-2-amino-5-methyl-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide. Grades: ≥98%. CAS No. 1388651-30-6. Molecular formula: C19H18F3N5O2S. Mole weight: 437.44. | |
| Eletriptan | Eletriptan is Serotonin 1D receptor agonist originated by Pfizer. It is a second generation triptan drug. It is used as an abortive medication, blocking a migraine attack which is already in progress. Eletriptan was approved by the FDA for the acute treatment of migraine with or without aura in adults in 2002. Uses: Menstrual migraine; migraine. Synonyms: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole; (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-methylpyrrolidin-2-yl)methyl]-1H-indole; Eletriptan; UK 116044; UK-116,044; UK-116,044-04 [as hydrobromide]; UNII-22QOO9B8KI; Relpax free amine. Grades: 98%. CAS No. 143322-58-1. Molecular formula: C22H26N2O2S. Mole weight: 382.52. | |
| Elinafide | Elinafide, an isoquinoline derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in anticancer studies. Synonyms: Elinafide; UNII-HL580335SI; Elinafide [INN]; 2- [2- [3- [2- (1, 3-dioxobenzo [de]isoquinolin-2-yl) ethylamino]propylamino]ethyl]benzo [de]isoquinoline-1, 3-dione; LU-79553. Grades: 98%. CAS No. 162706-37-8. Molecular formula: C31H28N4O4. Mole weight: 520.59. | |
| Elinogrel | Elinogrel is a P2Y12 antagonist displaying antiplatelet activity. Synonyms: 5-Chloro-N-[[[4-[6-Fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide. Grades: ≥98% by HPLC. CAS No. 936500-94-6. Molecular formula: C20H15ClFN5O5S2. Mole weight: 523.95. | |
| ELN 441958 | ELN441958 is a novel, potent and selective bradykinin B1 receptor antagonist with Ki value of 0.26 nM. It competitively inhibited the binding of the agonist [3H]DAKD to the human B1 receptor in IMR-90 lung fibroblast cell membranes. It is highly selective for B1 over B2 receptors and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor. It also inhibited human μ-, δ-, κ- opioid receptors and muscarinic M1 receptor with Ki values of 0.13, 0.69, 1.5 and 0.37 μM, respectively. It exhibited good permeability and metabolic stability in vitro. It exhibited high oral bioavailability and moderate plasma half-lives in rats and rhesus monkeys. It does not inhibit the activation of the human bradykinin B2 receptor at concentrations up to 10 μM. It has a moderate clearance and volume of distribution in both species following i.v. administration, consistent with the high metabolic stability in rat, rhesus, and human microsomes. Uses: Eln441958 exhibited high oral bioavailability and moderate plasma half-lives. Synonyms: ELN441958; ELN 441958; ELN-441958;7-Chloro-2-[3-[[9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecan-3-yl]carbonyl]phenyl]-2,3-dihydroisoindol-1-one. Grades: >98%. CAS No. 913064-47-8. Molecular formula: C29H29ClN4O2. Mole weight: 501.02. | |
| ELND006 | ELND006 is one of the newest molecules to be reported on regarding the testing of the β-amyloid hypothesis. ELND006 is a novel oral γ-secretase inhibitor. At the 2010 Alzheimer's Association International Conference on Alzheimer's Disease in which ELND006 was reported to have an in vitro IC50 = 0.34 nM against APP and IC50 = 5.3 nM versus Notch signaling. Synonyms: ELND006; ELND-006; ELND 006. (4R)-4-cyclopropyl-7,8-difluoro-5-[4-(trifluoromethyl)phenyl]sulfonyl-1,4-dihydropyrazolo[4,3-c]quinoline; UNII-7F5QGV49GL; ELND006; ELND-006; 959997-22-9; (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo(4,3-c)quinoline; (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline; 7F5QGV49GL; SCHEMBL486044; GTPL7337; CHEMBL2396778. CAS No. 1333990-84-3. Molecular formula: C20H14F5N3O2S. Mole weight: 455.07. | |
| ELND007 | ELND007 is a γ-secretase inhibitor. Synonyms: ELND007; ELND-007; ELND 007. (R)-4-cyclopropyl-8-fluoro-5-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline; ELND007; ELND-007; ELND 007. CAS No. 1444006-79-4. Molecular formula: C19H14F4N4O2S. Mole weight: 438.08. | |
| Elomotecan HCl salt | Elomotecan, also referred to BN 80927 and R 1559, characterized by a stable seven-membered beta-hydroxylactone ring, is a DNA topoisomerase inhibitor. In vivo elomotecan shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Synonyms: 220997-99-9; 220998-10-7 (Elomotecan free base); (5R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methylpiperidin-1-yl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione hydrochloride (1:1). Grades: >98%. CAS No. 220997-99-9. Molecular formula: C29H33Cl2N3O4. Mole weight: 558.5. | |
| Elpetrigine | Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders and epilepsy. Synonyms: 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine; GW273293; GW-273293; GW 273293; JZP-4; JZP 4; JZP4; Elpetrigine. Grades: >98%. CAS No. 212778-82-0. Molecular formula: C10H7Cl3N4. Mole weight: 289.54. | |
| ELR510444 | ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR510444 potently inhibited cell proliferation with an IC(50) value of 30.9 nM in MDA-MB-231 cells, inhibited the rate and extent of purified tubulin assembly, and displaced colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site. ELR510444 is not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines, suggesting that it circumvents both clinically relevant mechanisms of drug resistance to this class of agents. ELR510444 also shows potent antitumor activity in the MDA-MB-231 xenograft model with at least a 2-fold therapeutic window. Synonyms: ELR510444; ELR-510444; ELR 510444. Grades: >98%. CAS No. 1233948-35-0. Molecular formula: C19H16N2O2S2. Mole weight: 368.47. | |
| Eltoprazine | Eltoprazine belongs the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It is closely related to fluprazine and batoprazine, which are similarly acting drugs. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It was found to (synergistically) potentiate the antidyskinetic effect of amantadine. It has been shown to reduce 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-;1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine;DU-28853;DU28853. Grades: >98 %. CAS No. 98224-03-4. Molecular formula: C12H16N2O2. Mole weight: 220.27. | |
| Elubrixin | Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist. It is potentially useful for Inflammatory bowel disease therapies. It inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. It may be an effective agent in neutrophil-predominant diseases. It was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated. Uses: Elubrixin is potentially useful for inflammatory bowel disease therapies. it may be an effective agent in neutrophil-predominant diseases. Synonyms: 1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea;SB-656933;SB656933;SB-656933-AAF;SB-656933-AAA;SB656933AAA;SB656933AAF;1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea. Grades: 98%. CAS No. 688763-64-6. Molecular formula: C17H17Cl2FN4O4S. Mole weight: 463.30. | |
| Elzasonan citrate | Elzasonan citrate is a selective 5-hydroxytryptamine 1B receptor antagonist for treat patients with major depressive disorder and obsessive compulsive disorder. Uses: Serotonin 1b receptor antagonists; serotonin 1d receptor antagonists. Synonyms: (2Z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one;2-hydroxypropane-1,2,3-tricarboxylic acid. Grades: ≥98%. CAS No. 361343-20-6. Molecular formula: C28H31Cl2N3O8S. Mole weight: 640.53. | |
| Elzasonan hydrochloride | Elzasonan, also called as CP 448187, exhibits potent and selective antagonism of 5-HT1B receptors in vitro, and preclinical in vivo studies demonstrate enhanced 5-HT neurotransmission. Elzasonan is able to improve signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects. Synonyms: (2Z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one;hydrochloride; Elzasonan hydrochloride; Elzasonan HCl; UNII-X38F62RR8L. Grades: >98%. CAS No. 220322-05-4. Molecular formula: C22H24Cl3N3OS. Mole weight: 484.86. | |
| EM574 | EM574 is an agonist of motilin receptor with an IC50 value of 6.17 nM which binds to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay. Synonyms: Idremcinal; 8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin. Grades: ≥98%. CAS No. 110480-13-2. Molecular formula: C39H69NO12. Mole weight: 743.96. | |
| EMA401 | EMA401 is an orally bioavailable, potent and highly selective antagonist of the angiotensin II type 2 receptor (AT2; IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively). It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite density and length in rat DRG neuronal cultures. Synonyms: EMA 401; EMA-401; Olodanrigan; (3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid. Grades: ≥ 95 %. CAS No. 1316755-16-4. Molecular formula: C32H29NO5. Mole weight: 507.6. | |
| Embusartan | Embusartan, an oxopyridine derivative, has been found to be an angiotensin II receptor antagonist that was once studied against hypertension by Bayer. Synonyms: Embusartan; UNII-4MY73645XA; Embusartan [INN]; Bay 10-6734; Bay-10-6734; methyl 2-butyl-1-[[2-fluoro-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-6-oxopyridine-4-carboxylate. Grades: 98%. CAS No. 156001-18-2. Molecular formula: C25H24FN5O3. Mole weight: 461.49. | |
| EMD 281014 hydrochloride | EMD 281014 hydrochloride is a selective 5-HT2A antagonist with preference for human 5-HT2A over 5-HT2C receptors (Ki = 0.87 and 557 nM, respectively). EMD 281014 has the potential to treat insomnia. Uses: Potential treatment of insomnia. Synonyms: EMD 281014 hydrochloride; EMD281014 hydrochloride; EMD-281014 hydrochloride; Pruvanserin hydrochloride; Pruvanserin HCl; 7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride. Grades: ≥98% by HPLC. CAS No. 443144-27-2. Molecular formula: C22H21FN4O.HCl. Mole weight: 412.89. | |
| EMD 386088 hydrochloride | EMD 386088 hydrochloride is a potent and selective 5-HT6 receptor agonist (EC50 = 1.0 nM) (IC50 = 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors, respectively) used as an antidepressant. Synonyms: 1H-Indole, 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, hydrochloride (1:1); EMD386088 hydrochloride; EMD-386088 hydrochloride; 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 1171123-46-8. Molecular formula: C14H15N2Cl.HCl. Mole weight: 283.20. | |
| EMD638683 R-Form | EMD638683 (R-Form) is a SGK1 inhibitor with an IC50 of < 300 nM. Synonyms: EMD 638683 (R-Form); EMD638683 (R-Form); EMD-638683 (R-Form). Grades:>98%. CAS No. 1184940-47-3. Molecular formula: C18H18F2N2O4. Mole weight: 364.34. | |
| EMD638683 S-Form | EMD638683 (S-Form) is a SGK1 inhibitor with an IC50 of >300 nM. Synonyms: EMD 638683 (S-Form); EMD638683 (S-Form); EMD-638683 (S-Form). Grades: >98%. CAS No. 1184940-46-2. Molecular formula: C18H18F2N2O4. Mole weight: 364.34. | |
| EMD 66684 | EMD 66684 is a potent and selective non-peptide angiotensin AT1 receptor antagonist (IC50 = 0.7 and >10000 nM for AT1 and AT2 receptors, respectively). It inhibits isolated rabbit aorta contractions induced by angiotensin II (IC50 = 0.2 nM) and lowers blood pressure in hypertensive rats. Synonyms: 5H-Imidazo[4,5-c]pyridine-5-acetamide, 2-butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, potassium salt (1:1); Potassium 5-(4'-((2-butyl-5-(2-(dimethylamino)-2-oxoethyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-yl)tetrazol-1-ide; 5H-Imidazo[4,5-c]pyridine-5-acetamide, 2-butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, potassium salt; EMD-66684; EMD66684. Grades: ≥95%. CAS No. 187683-79-0. Molecular formula: C28H29KN8O2. Mole weight: 548.69. | |
| EMDT oxalate | EMDT oxalate is a selective 5-HT6 agonist (Ki = 16 nM at human 5-HT6 receptors) with antidepressant-like activity. It shows potency comparable to serotonin for the activation of adenylate cyclase. Synonyms: J-016404; J 016404; J016404; 2-Ethyl-5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine oxalate. Grades: ≥98% by HPLC. CAS No. 263744-72-5. Molecular formula: C15H22N2O.C2H2O4. Mole weight: 336.38. | |
| Emedastine | Emedastine is a potent, high affinity and selective antagonist of histamine H1-receptor with Ki of 1.3 for H1-receptors while significantly weaker at H2- (K1 = 49,067 nM) and H3-receptors (Ki = 12,430 nM). Uses: Anti-allergic agents. Synonyms: 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole. Grades: ≥97%. CAS No. 87233-61-2. Molecular formula: C17H26N4O. Mole weight: 302.41. | |
| Emricasan | Emricasan is a pan-caspase inhibitor with antiapoptotic and antiinflammatory activity. It was shown that emricasan decreased caspase activity, serum alanine aminotransferase (ALT), and hepatic fibrogenesis in a murine model of non-alcoholic steatohepatitis. Emricasan has been granted fast track designation by the FDA for the treatment of non-alcoholic steatohepatitis cirrhosis. Uses: Liver disease therapy. Synonyms: IDN-6556; IDN6556; IDN 6556; PF 03491390; PF-03491390; PF03491390; (3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid. Grades: 99.59%. CAS No. 254750-02-2. Molecular formula: C26H27F4N3O7. Mole weight: 569.51. | |
| Enadoline hydrochloride | Enadolineis a potent selective Opioid kappa receptor agonists originated by Pfizer. However, clinical trials for the treatment of Arrhythmias, Neuroprotection and Pain were discontinued. Uses: Arrhythmias; neuroprotection; pain. Synonyms: UNII-086I9HO04E; CAM 570; CI-977; NIH 10672; CAM570; CI977; NIH10672; CAM-570; CI 977; NIH-10672; 2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide;hydrochloride. Grades: 98%. CAS No. 124439-07-2. Molecular formula: C24H33ClN2O3. Mole weight: 432.99. | |
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