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| Product | Description | |
|---|---|---|
| CP866087 | CP866087 is a selective mu-opioid receptor antagonist. Synonyms: CP-866087; CP 866087; CP866087; N-[3-[(1R, 5S)-6-ethyl-3-[(2-hydroxy-1, 3-dihydroinden-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]methanesulfonamide; Methanesulfonamide, N-(3-(3-((2,3-dihydro-2-hydroxy-1H-inden-2-yl)methyl)-6-ethyl-3-azabicyclo(3.1.0)hex-6-yl)phenyl)-. Grades: 98%. CAS No. 519052-02-9. Molecular formula: C24H30N2O3S. Mole weight: 426.57. |  |
| CP-8668 | CP-8668 is an orally active nonsteroidal progesterone receptor modulator with no significant affinity for human glucocorticoid receptor or human estrogen receptor and very weak affinity for rat androgen receptor. Synonyms: [(4aR,5R,6R,7R)-7-methoxy-1,3,4a,5-tetramethyl-2-oxo-4,5,6,7-tetrahydrobenzo[f]indol-6-yl] N-propylcarbamate; (4aR,5R,6R,7R)-7-methoxy-6-(N-propylaminocarbonyl)oxy-4a,5,6,7-tetrahydro-1,3,4a,5-tetramethylbenz(f)indol-2(4H)-one; CP-8668; CP8668; CP 8668; UNII-5371O2R79D. Grades: >98%. CAS No. 209331-43-1. Molecular formula: C21H30N2O4. Mole weight: 374.47. | |
| CP 93129 dihydrochloride | The hydrochloride salt form of CP 93129, which is a 5HT1B agonist and exhibits activities in decreasing body weight as well as reducing food intake in rats. Synonyms: 5H-Pyrrolo[3,2-b]pyridin-5-one, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, hydrochloride (1:2); 5H-Pyrrolo[3,2-b]pyridin-5-one, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, dihydrochloride; CP93129 dihydrochloride; CP-93129 dihydrochloride; 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H,4H,5H-pyrrolo[3,2-b]pyridin-5-one dihydrochloride; 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ol dihydrochloride. Grades: ≥95% by HPLC. CAS No. 879089-64-2. Molecular formula: C12H13N3O.2HCl. Mole weight: 288.18. | |
| CP 94253 hydrochloride | The hydrochloride salt form of CP 94253, which is a 5-HT1B agonist and exhibit anticonvulsant activities. Synonyms: CP94253 hydrochloride; CP-94253 hydrochloride; 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride; 1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, hydrochloride (1:1); 1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, monohydrochloride. Grades: ≥98% by HPLC. CAS No. 845861-39-4. Molecular formula: C15H19N3O.HCl. Mole weight: 293.80. | |
| CP 96345 | CP 96345 is an effective and selective non-peptide NK1 receptor antagonist and has been found to show activities in restraining neurogenic inflammation in vivo. Uses: Hypnotics and sedatives. Synonyms: CP-96345; CP 96345; CP96345; (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine. Grades: ≥98% by HPLC. CAS No. 132746-60-2. Molecular formula: C28H32N2O. Mole weight: 412.57. | |
| CP 99433 | CP 99433, a fluoroquinolone derivative, has been found to be a Type II DNA topoisomerase inhibitor that could be probably effective as an antibacterial agent. Synonyms: CP 99433; CP99433; CP-99433. 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv; 1,?8-Naphthyridine-3-carboxylic acid, 7-(6-amino-3-azabicyclo[3.1.0]?hex-3-yl)?-1-cyclopropyl-6-fluoro-1,?4-dihydro-4-oxo-, (1α,?5α,?6α)?-. Grades: 98%. CAS No. 147059-71-0. Molecular formula: C17H17FN4O3. Mole weight: 344.34. | |
| CP 99994 dihydrochloride | The hydrochloride salt form of CP 99994, which is a high affinity NK1 antagonist and could attenuate endothelium-dependent contraction induced by substance P. Synonyms: CP 99994 dihydrochloride; CP99994 dihydrochloride; CP-99994 dihydrochloride; (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 145148-39-6. Molecular formula: C19H24N2O.2HCl. Mole weight: 369.33. | |
| CPA inhibitor | CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA). Synonyms: carboxypeptidase inhibitor; Benzenepropanoic acid. alpha.-[[hydroxy(2-phenylacetyl)amino]methyl]-. Grades: >98%. CAS No. 223532-02-3. Molecular formula: C18H19NO4. Mole weight: 313.35. | |
| CPCCOEt | CPCCOEt has been found to be a mGluR-1 antagonist. Synonyms: 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester. Grades: ≥99% by HPLC. CAS No. 179067-99-3. Molecular formula: C13H13NO4. Mole weight: 247.25. | |
| CPDA | CPDA, a 4-substituted 2-pyridin-2-ylamide, has potential to inhibit SHIP2 which was found to enhance insulin signaling through the Akt pathway in viro and greatly improved abnormal glucose metabolism in diabetic animals. Synonyms: N-[4-[(4-chlorophenyl)methoxy]pyridin-2-yl]-2-(2,6-difluorophenyl)acetamide CPDA CHEMBL2337808 SCHEMBL14156872 AKOS027447209 CS-4991 AK517293 HY-18685 N-[4-(4-Chlorobenzyloxy)-2-pyridyl]-2,6-difluorobenzeneacetamide N-(4-((4-Chlorobenzyl)oxy)pyridin-2-yl). CAS No. 1415834-63-7. Molecular formula: C20H15ClF2N2O2. Mole weight: 388.79. | |
| CpdD hydrochloride | CpdD hydrochloride is a selective ghrelin receptor (GhrR aka GHSR-1a) antagonist. Synonyms: N-[(1R)-1-[3-[(4-bromophenyl)methyl]-1,2,4-oxadiazol-5-yl]-3-phenylpropyl]-3-(diethylamino)propane-1-sulfonamide hydrochloride. Grades: 99%. Molecular formula: C25H33BrN4O3S.HCl. Mole weight: 585.98. | |
| CPG52364 | CPG52364 a small molecule toll-like receptor(TLR) antagonist, which is a type I transmembrane receptors and the central components of the innate immune system. It has recently completed phase 1 clinical trial for SLE therapy. Uses: Cpg52364 is used for the sle therapy. Synonyms: CPG-52364; CPG 52364; CPG52364; 6,7-Dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholinoethyl)quinazolin-4-amine. Grades: >98%. CAS No. 1093135-60-4. Molecular formula: C27H36N6O3. Mole weight: 492.62. | |
| CPG52364 sulfate | CPG52364 sulfate is the sulfate form of CPG52364, which is a small molecule toll-like receptor(TLR) antagonist. It has recently completed phase 1 clinical trial for SLE therapy. Uses: Cpg52364 sulfate is used for the sle therapy. Synonyms: CPG-52364 sulfate; CPG 52364 sulfate; CPG52364 sulfate; 6,7-Dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholinoethyl)quinazolin-4-amine sulfate. Grades: >98%. CAS No. 1093135-62-6. Molecular formula: C27H38N6O7S. Mole weight: 590.70. | |
| CPI-169 | CPI-169 is a novel and potent EZH2 inhibitor, it decreases cellular levels of H3K27me3 and triggers cell cycle arrest and apoptosis in a variety of cell lines. Synonyms: CPI-169; CPI 169; CPI169. Grades: >98%. CAS No. 1450655-76-1. Molecular formula: C27H36N4O5S. Mole weight: 528.66. | |
| CPI-268456 | CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 and inhibits LPS-induced IL-6 secretion in THP-1 cells. Synonyms: 2-[(4S)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide. Grades: ≥98%. CAS No. 1380087-86-4. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.3. | |
| CPI-360 | CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases. Synonyms: CPI-360; CPI360; CPI 360. Grades: 98%. CAS No. 1802175-06-9. Molecular formula: C25H31N3O4. Mole weight: 437.53. | |
| CPI 4203 | CPI 4203 is a selective inhibitor of KDM5 demethylases structurally related to CPI 455. Synonyms: CPI-4203; CPI 4203; CPI4203; 6-ethyl-7-oxo-5-(o-tolyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grades: 99%. CAS No. 1628214-07-2. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI 455 | CPI 455 is a selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation (H3K4me3) in vitro and reduces survival of drug-tolerant cancer cells. Uses: Antitumor agent for drug-tolerant cancer. Synonyms: CPI-455; CPI-455; CPI-455; 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grades: 99%. CAS No. 1628208-23-0. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI-455 hydrochloride | CPI-455 is a specific inhibitor of KDM5 with IC50 of 10 ± 1 nM for full-length KDM5A in enzymatic assays. Synonyms: 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride. Grades: ≥99%. CAS No. 2095432-28-1. Molecular formula: C16H15ClN4O. Mole weight: 314.77. | |
| [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide | A Y5 receptor-selective agonist (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1-0.15 nM). Synonyms: GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY. CAS No. 313988-89-5. Molecular formula: C183H281N57O54S2. Mole weight: 4207.67. | |
| CPPG | CPPG is the most potent group II/III mGluR antagonist displaying approximately 20-fold selectivity for group III over group II (IC50 = 2.2 and 46.2 nM, respectively). Synonyms: (RS)-α-Cyclopropyl-4-phosphonophenylglycine; Cyclopropyl-4-phosphonophenylglycine; 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid. Grades: ≥98% by HPLC. CAS No. 183364-82-1. Molecular formula: C11H14NO5P. Mole weight: 271.21. | |
| CPPHA | CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It is thought to act at a novel allosteric site and potentiates mGlu5 responses by a mechanism distinct from that of VU 29. Grades: >98%. CAS No. 693288-97-0. Molecular formula: C22H15ClN2O4. Mole weight: 406.82. | |
| CPTH2 | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating Gcn5p network in vitro and in vivo. HAT is an enzyme playing an important role in histone acetylation and multiple cancer development. Uses: Antitumor agent. Synonyms: CPTH2; CPTH 2; CPTH-2; Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone. Grades: 99%. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8. | |
| CPTH2 hydrochloride | Gcn5 is a chromatin modifying factor that has HAT activity to acetylate histone H3 lysine 9 (K9) and K14. CPTH2 inhibits the HAT activity of Gcn5. It is used to study the influence of Gcn5-dependent acetylation in various biological systems. Synonyms: 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone monohydrochloride. Grades: ≥95%. CAS No. 2108899-91-6. Molecular formula: C14H14ClN3S·HCl. Mole weight: 328.3. | |
| CPTH6 hydrobromide | CPTH6 is a thiazole derivative structurally and it can inhibit the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP. Synonyms: 3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone cyclopentanone hydrobromide. Grades: ≥98%. CAS No. 2321332-57-2. Molecular formula: C15H16ClN3S·HBr. Mole weight: 386.7. | |
| CPUY201112 | CPUY201112 is an N-terminal Hsp90 inhibitor, which leads to decreased expression of Hsp90 client proteins and may result in increased tumor cell apoptosis. Synonyms: CPUY201112; CPUY 201112; CPUY-201112. Grades: >98%. CAS No. 1860793-58-3. Molecular formula: C19H23N3O4. Mole weight: 357.41. | |
| CRANAD 28 | CRANAD 28 is a curcumin derivative and a fluorescent probe for labeling amyloid-β (Aβ) plaques and cerebral amyloid angiopathy. The fluorescence intensity decreases when bound to A&beta. It also inhibits copper-induced and naturally occurring Aβ crosslinking. Synonyms: CRANAD-28; CRANAD 28; CRANAD28. Grades: ≥98%. CAS No. 1623747-97-6. Molecular formula: C27H23BF2N4O2. Mole weight: 484.3. | |
| Crenolanib | Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Synonyms: CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; Crenolanib. CAS No. 670220-88-9. Molecular formula: C26H29N5O2. Mole weight: 443.551. | |
| Crizotinib hydrochloride | Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grades: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. | |
| Cromakalim | Cromakalim is a prototypical Kir6 (KATP) channel opener. It is used as a potassium channel-opening vasodilator. It acts on ATP-sensitive potassium channels and causes membrane hyperpolarization. It displays cardioprotective and anti-ischemic effects in rat hearts. It can be used to treat hypertension because it will relax vascular smooth muscle to lower blood pressure. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance. It is orally active in vivo. Synonyms: BRL 34915; BRL-34915; BRL34915; Cromakalim; (±)-Cromakalim; (±)-Cromakalim; (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; (±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol. Grades: ≥99% by HPLC. CAS No. 94470-67-4. Molecular formula: C16H18N2O3. Mole weight: 286.33. | |
| CRSP-1 | CRSP-1 has been found to be an endogenous central calcitonin (CT) receptor agonist and could reduce plasma calcium levels in vivo. Synonyms: CRSP-1; CRSP 1; CRSP1. Grades: ≥95% by HPLC. CAS No. 697327-12-1. Molecular formula: C175H294N54O49S5. Mole weight: 4098.88. | |
| CRT0066854 | CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCΙ, respectively). CRT0066854 decreases colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. Synonyms: CRT0066854; CRT 0066854; CRT-0066854; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine. Grades: 99%. CAS No. 1438881-19-6. Molecular formula: C24H25N5S. Mole weight: 415.55. | |
| CRT 0066854 hydrochloride | The hydrochloride salt form of CRT 0066854, which has been found to be a PKC inhibitor. Synonyms: CRT 0066854 hydrochloride; CRT0066854 hydrochloride; CRT-0066854 hydrochloride; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C24H25N5S.2HCl. Mole weight: 488.48. | |
| CS1 | CS1 is a Topo IIα inhibitor with broad-spectrum in vitro antitumor activity. CS1 acts as a Topo II poison to stabilize Topo II/DNA complex causing DNA damage, cell cycle arrest at G2/M phase, and apoptosis. Uses: Antitumor agent. Synonyms: CS-1; CS 1; CS1; 4-(6-Hydroxy-2-naphthalenyl)-1,2-benzenediol. Grades: 99%. CAS No. 1448009-94-6. Molecular formula: C16H12O3. Mole weight: 252.26. | |
| CS-7017 monohydrate | CS-7017 monohydrate is a peroxisome proliferator activated receptor gamma (PPAR) agonist. It is a potential therapy for thyroid cancer and liposarcoma. It is also used for the treatment of rectal cancer and non-small cell lung cancer. It was developed by Daiichi Sankyo Company Limited. It is in clinic phase 2 with no progress. Uses: Cs-7017 monohydrate is a potential therapy for thyroid cancer and liposarcoma. it is also used for the treatment of rectal cancer and non-small cell lung cancer. Synonyms: CS-7017 monohydrate; CS 7017 monohydrate; CS7017 monohydrate; Efatutazone dihydrochloride monohydrate;5-[[4-[[6-(4-Amino-3,5-dimethylphenoxy)-1-methylbenzimidazol-2-yl]methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione hydrate dihydrochloride;Inolitazone dihydrochloride monohydrate;(+/-)-2,4-Thiazolidinedione, 5-((4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-yl)methoxy)phenyl)methyl)-, dihydrochloride, monohydrate. Grades: >99 %. CAS No. 1048002-36-3. Molecular formula: C27H30Cl2N4O5S. Mole weight: 593.52. | |
| CS-834 | CS-834, a carbapenem derivative, has been found to be a cell wall inhibitor that was once studied as an antiibacterial agent by Sankyo. Synonyms: CS 834; CS834; CS-834; UNII-H26S03B779; [(2,2-dimethylpropanoyl)oxy]methyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-{[(3R)-5-oxopyrrolidin-3-yl]sulfanyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate. Grades: 98%. CAS No. 157542-49-9. Molecular formula: C20H28N2O7S. Mole weight: 440.51. | |
| CT7001 hydrochloride | CT7001, also known as ICEC0942, is an orally bioavailable CDK7 inhibitor with IC50 value of 40nM. CDK7 phosphorylates the C-terminal domain (CTD) of RNA polymerase II (PolII) to enable transcription initiation, and also affects some transcriptional factor activities, resulting in suppression of types of cancers. Synonyms: ICEC0942 hydrochloride; (3R,4R)-4-[[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol hydrochloride. CAS No. 1805789-54-1. Molecular formula: C22H31ClN6O. Mole weight: 430.97. | |
| CTAP trifluoroacetate salt | CTAP is a water-soluble and selective antagonist of the μ opioid receptor (IC50 = 3.5 nM) over the δ receptor (IC50 = 4,500 nM). It is a cyclic octapeptide which acts as a poor antagonist of the somatostatin receptor (IC50 = 14.3 μM). CTAP is at least 10-fold more potent than naltrexone. Molecular formula: C51H69N13O11S2·xCF3COOH. Mole weight: 1104.31. | |
| CTEP | CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor (IC50=2.2 nM), showing >1000-fold selectivity over other mGlu receptors. Synonyms: RO4956371; RO-4956371; RO 4956371; CTEP. Grades: >98%. CAS No. 871362-31-1. Molecular formula: C19H13ClF3N3O. Mole weight: 391.77. | |
| CTOP trifluoroacetate salt | CTOP is a peptide that acts as a selective antagonist of the μ-opioid receptor (IC50 = 2.8 nM). CTOP inhibits the antinociceptive effect of morphine in the tail flick test in mice (ED50 = 0.018 nmol) and reverses morphine-induced increases in locomotor activity (ED50 = 0.02 nmol). Synonyms: Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr; D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide-cyclic (2?7)-disulfide trifluoroacetate salt. Grades: ≥98%. Molecular formula: C50H67N11O11S2·xCF3COOH. Mole weight: 1062.3 (free base). | |
| CTPB | CTPB is an amide derivative that acts as a selectively activator of the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl-benzamide. Grades: ≥98%. CAS No. 586976-24-1. Molecular formula: C31H43ClF3NO2. Mole weight: 554.1. | |
| CTS-1027 | CTS-1027 inhibits individual members of the MMP family that are believed to be important in inflammation and tissue damage. CTS-1027 was specifically designed, however, not to inhibit MMP 1, as inhibition of MMP 1 was believed to be associated with musculoskeletal side effects. Synonyms: RS 130830; Ro 1130830; CTS1027; CTS 1027; RS130830; Ro1130830; RS-130830; Ro-1130830. Grades: >98%. CAS No. 193022-04-7. Molecular formula: C19H20ClNO6S. Mole weight: 425.88. | |
| CTS-21166 | CTS-21166, the selective BACE1 inhibitor whose structure is not revealed, reduce brain Aβ levels by over 35% and plaque load by 40%. Phase 1 IC50=1.2-3.6 nM (cell line details NA) APP transgenic mice, 4mg/kg i.p. injection for 6 weeks, >35% ↓ brain Aβ, 40% ↓ plaque load. Human patients, 7.5.225 mg i.v. injection dose-dependant ↓ plasma Aβ, 80% ↓ at 225 mg. Synonyms: ATG-Z1; CTS-21166; ZPQ-21166; ATG Z1; CTS 21166; ZPQ 21166; ATGZ1; CTS21166; ZPQ21166. Molecular formula: none. | |
| CUDC-101 | CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC. Synonyms: CUDC101; CUDC 101; CUDC-101. CAS No. 1012054-59-9. Molecular formula: C24H26N4O4. Mole weight: 434.496. | |
| CUDC-907 | CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Synonyms: CUDC907; CUDC 907; CUDC-907. CAS No. 1339928-25-4. Molecular formula: C23H24N8O4S. Mole weight: 508.557. | |
| CUR 61414 | CUR 61414 inhibits the activity of hedgehog-induced cellular (IC50 = 100-200 nM). It binds directly with the pathway activator Smoothened (Ki = 44 nM). Synonyms: G-856; N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide. Grades: ≥98%. CAS No. 334998-36-6. Molecular formula: C31H42N4O5. Mole weight: 550.7. | |
| Curvulin | Curvulin is a phytotoxin that is first isolated from several species of the mold Curvularia. Curvulin inhibits microtubule assembly and has also been proved to inhibit iNOS expression. Synonyms: 2-acetyl-3,5-dihydroxy-benzeneacetic acid ethyl ester. Grades: ≥98%. CAS No. 19054-27-4. Molecular formula: C12H14O5. Mole weight: 238.2. | |
| Cuspin-1 | Cuspin-1 is an upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells). Increased phosphorylation of ERK initiates Ras-Raf-MEK signaling, upregulating SMN protein levels in spinal muscular atrophy (SMA) patient fibroblasts. Synonyms: 3-bromo-5-(4-methylbenzoyl)pyridine; (5-bromopyridin-3-yl)-(4-methylphenyl)methanone. Grades: 99%. CAS No. 337932-29-3. Molecular formula: C13H10BrNO. Mole weight: 276.13. | |
| Cutamesine | Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuroprotection and regeneration in the context of neurodegenerative disease. in vitro: reduced SOD1. Uses: Nootropic agents. Synonyms: 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (11C)SA4503 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride cutamesine SA 4503 SA-4503 SA4503. CAS No. 165377-43-5. Molecular formula: C23H32N2O2. Mole weight: 368.51. | |
| CV-6209 chloride | CV-6209 is a potent platelet-activating factor (PAF) receptor antagonist, which inhibits aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little effect on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo. Synonyms: 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium monochloride. Grades: ≥95%. CAS No. 100488-87-7. Molecular formula: C34H60N3O6·Cl. Mole weight: 642.3. | |
| CVT5440 | CVT5440 is a selective, high affinity A(2B) adenosine receptor antagonist. It may has the potential treatment of asthma and has good selectivity. Uses: Cvt5440 may has the potential treatment of asthma and has good selectivity. Synonyms: CVT-5440; CVT5440; CVT 5440; UNII-29S2U9DRGS;1H-Purine-2,6-dione, 3,7-dihydro-8-(4-((5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)-1,3-dipropyl-;8-[4-[[5-(3-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]methoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione. Grades: 98%. CAS No. 531506-64-6. Molecular formula: C27H28N6O5. Mole weight: 516.55. | |
| CW-069 | CW-069 is a novel and allosteric inhibitor of the microtubule motor protein HSET, it shows statistically significant selectivity over KSP. Synonyms: CW069; CW-069; CW 069. Grades: >98%. CAS No. 1594094-64-0. Molecular formula: C23H21IN2O3. Mole weight: 500.33. | |
| CX546 | It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine drug that facilitates activation of glutamatergic AMPA receptors. Synonyms: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone; 1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbonyl]piperidine; CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; GR87; BDP17; BDP-17. Grades: >98%. CAS No. 215923-54-9. Molecular formula: C14H17NO3. Mole weight: 247.29. | |
| CX 614 | CX 614 has been found to be an AMPA modulator and has also been found to be an ampakine drug facilitating activation of glutamatergic AMPA receptors. Synonyms: CX614; CX 614; CX-614. 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one. Grades: ≥99% by HPLC. CAS No. 191744-13-5. Molecular formula: C13H13NO4. Mole weight: 247.25. | |
| CXCR2-IN-1 | CXCR2-IN-1 is a CXCR2 antagonist (pIC50 = 9.3) with favorable central nervous system penetration property (Br/Bl>0.45). Synonyms: 1-(2-chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(1-methylpiperidin-4-yl)sulfonylphenyl]urea. CAS No. 1873376-49-8. Molecular formula: C19H20Cl2FN3O4S. Mole weight: 476.35. | |
| CXCR3 Antagonist 6c | CXCR3 Antagonist 6c is a potent and selective chemokine CXCR3 antagonist (IC50 value of 60 nM in a calcium mobilization functional assay). It inhibits CXCR3 functional response to CXCL11 as measured by T-cell chemotaxis. Synonyms: 4-[2-[ (3-chlorobenzoyl) amino]-4-[2- (2, 4-dichlorophenyl) ethylcarbamoyl]phenyl]-N-ethyl-1, 4-diazepane-1-carboxamide. Grades: 99%. CAS No. 870998-13-3. Molecular formula: C30H32Cl3N5O3. Mole weight: 616.97. | |
| CY 208-243 | CY 208-243 is a D1DR receptor agonist and has been found to show antiparkinsonian activity in animal models. Synonyms: CY 208-243; CY-208-243; CY208243; (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin. Grades: ≥95% by HPLC. CAS No. 100999-26-6. Molecular formula: C19H18N2. Mole weight: 274.36. | |
| Cyanoacetohydrazide | Cyanoacetohydrazide, a cyanoaceto compound, could be used in the treatment of tuberculosis. Uses: Cyanoacetohydrazide could be used in the treatment of tuberculosis. Synonyms: 2-cyanoacetohydrazide. Grades: 98 %. CAS No. 140-87-4. Molecular formula: C3H5N3O. Mole weight: 99.09. | |
| Cyanopindolol hemifumarate | Cyanopindolol hemifumarate is the hemifumarate salt of cyanopindolol, which is a 5-HT1A/1B antagonist. It is also a β-adrenoceptor antagonist. It has roughly equal affinity for each receptor. Synonyms: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate. Grades: ≥98% by HPLC. CAS No. 69906-86-1. Molecular formula: C18H23N3O5. Mole weight: 345.40. | |
| CYC065 | CYC065 is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with potential antineoplastic and chemoprotective activities. Synonyms: CYC065; CYC 065; CYC-065; (2R,3S)-3-[[6-[(4,6-dimethylpyridin-3-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol. CAS No. 1070790-89-4. Molecular formula: C21H31N7O. Mole weight: 397.52. | |
| CYC116 | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1. Synonyms: CYC116; CYC 116; CYC-116. CAS No. 693228-63-6. Molecular formula: C18H20N6OS. Mole weight: 368.46. | |
| Cyclapolin 9 | Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor with IC50 value of 500 nM. It is selective against a panel of 20 kinases. Synonyms: Cyclapolin-9; Cyclapolin 9; Cyclapolin9; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide. Grades: ≥98% by HPLC. CAS No. 40533-25-3. Molecular formula: C9H4F3N3O4S. Mole weight: 307.21. | |
| Cyclophilin inhibitor 1 | Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin inhibitor, and it shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a. Synonyms: Cyclophilin inhibitor 1|CHEMBL4176386|SCHEMBL15907884|BDBM 50450030|HY-112712|CS-0062849. Grades: >98%. CAS No. 1509904-96-4. Molecular formula: C31H39N5O7. Mole weight: 593.67. | |
| Cyclosomatostatin | Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. It blocks the effects of CRF-induced suppression of gastric empyting and sst on airway β-adrenergic function. It also prevents growth hormone, insulin, glucagon release and modulation of ACh release. It acts as a sst receptor agonist in human neuroblastoma cell line SH-SY5Y. Uses: Hormone antagonists. Synonyms: Cyclo(7-aminoheptanonyl-Phe-D-Trp-Lys-Thr[Bzl]); Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl]. CAS No. 84211-54-1. Molecular formula: C44H57N7O6. Mole weight: 779.98. | |
| Cyclothiazide | Cyclothiazide has been found to be a subunit-specific inhibitor of GABAC receptors and could be used as a diuretic agent as well as antihypertensive agent. Uses: Antihypertensive agents; diuretics, thiazide. Synonyms: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide. Grades: ≥98% by HPLC. CAS No. 2259-96-3. Molecular formula: C14H16ClN3O4S2. Mole weight: 389.87. | |
| CYM 9484 | CYM 9484 has been found to be an effective neuropeptide Y (NPY) Y2 receptor antagonist. Synonyms: CYM 9484; CYM9484; CYM-9484; N-[4-[(Dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide. Grades: ≥98% by HPLC. CAS No. 1383478-94-1. Molecular formula: C27H31N3O3S2. Mole weight: 509.63. | |
| CyPPA | CyPPA is a positive modulator of the small conductance calcium-activated potassium channels. It is selective for KCa2.2 (SK2) and KCa2.3 (SK3) channels with EC50 values of 14 and 5.6 μM for KCa2.2 and KCa2.3 respectively, but it shows no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels. So it can be used for distinguishing SK2 and SK3 from SK1 and IK. It is also used to evaluate the roles of SK2 and SK3 in such diverse processes as uterine muscle contraction, dopamine signaling and memory encoding. It reduces the activity of dopaminergic neurons, counteracts hyperdopaminergic behaviors induced by methyl phenidate and inhibits dopamine release. Synonyms: N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine; N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine; Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine. Grades: ≥99% by HPLC. CAS No. 73029-73-9. Molecular formula: C16H23N5. Mole weight: 285.39. | |
| CYR-101 | MIN-101, a novel cyclic amide derivative, is a 5-HT2A and sigma 2 receptor antagonist (Ki = 7.53 nM for 5-HT2A and 8.19 nM for sigma-2, respectively). Synonyms: 2-((1-(2-(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one; CYR-101; UNII-4P31I0M3BF; MT-210; MIN101; CYR101; MT210; MIN 101; CYR 101; MT 210. CAS No. 359625-79-9. Molecular formula: C22H23FN2O2. Mole weight: 366.43. | |
| Cysteine Protease inhibitor | Cysteine Protease inhibitor is a inhibitor of cysteine protease. Synonyms: 2-Pyrimidinecarbonitrile, 4-[[4'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-. Grades: >98%. CAS No. 921625-62-9. Molecular formula: C18H14N4O. Mole weight: 302.33. | |
| CYT387 Mesylate | CYT387 Mesylate is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Synonyms: Momelotinib Mesylate; CYT387 Mesylate; CYT 387 Mesylate; CYT-387 Mesylate. Grades: >98%. CAS No. 1056636-07-7. Molecular formula: C24H26N6O5S. Mole weight: 510.57. | |
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