BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CYT387 sulfate salt | CYT387 sulfate is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Synonyms: momelotinib;CYT 387 sulfate salt; CYT387 sulfate salt; CYT-387 sulfate salt. Grades: >98%. CAS No. 1056636-06-6. Molecular formula: C23H26N6O10S2. Mole weight: 610.62. |  |
| Cytosporone B | Cytosporone B, also called as Csn-B or Dothiorelone G, is the first naturally nuclear orphan receptor Nur77 agonist with an EC50 of 0.278 nM. Synonyms: 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester; Cytosporone B, Csn-B. CAS No. 321661-62-5. Molecular formula: C18H26O5. Mole weight: 322.4. | |
| CZC24832 | CZC24832 is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target- and cell-based profiling of CZC24832 revealed regulation of interleukin-17-producing T helper cell (T(H)17) differentiation by PI3Kγ, thus reinforcing selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Synonyms: CZC24832; CZC-24832; CZC 24832. Grades: 0.98. CAS No. 1159824-67-5. Molecular formula: C15H17FN6O2S. Mole weight: 364.399. | |
| CZC-25146 | CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons. Synonyms: CZC25146; CZC 25146. Grades: >98%. CAS No. 1191911-26-8. Molecular formula: C22H25FN6O4S. Mole weight: 488.54. | |
| CZC-25146 hydrochloride | CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons's disease, and is ATP-competitive. Synonyms: CZC25146 hydrochloride; CZC 25146 hydrochloride. Grades: 0.98. CAS No. 1330003-04-7. Molecular formula: C22H26ClFN6O4S. Mole weight: 524.996. | |
| CZC-54252 | Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Synonyms: CZC-54252; CZC 54252; CZC54252. Grades: >98%. CAS No. 1191911-27-9. Molecular formula: C22H25ClN6O4S. Mole weight: 504.99. | |
| CZC-8004 | CZC-8004 is an aminopyrimidine which is a pan-kinase inhibitor that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Synonyms: Dianilinopyrimidine-01; CZC-00008004. Grades: ≥98%. CAS No. 916603-07-1. Molecular formula: C17H16FN5. Mole weight: 309.3. | |
| D 106669 | D 106669 is a potent and selective PI3K inhibitor. Synonyms: D-106669; D 106669; D106669; N-ethyl-N'-[3-[(4-methylphenyl)amino]pyrido[2,3-b]pyrazin-6-yl]Urea; 3-ethyl-1-{3-[(4-methylphenyl)amino]pyrido[2,3-b]pyrazin-6-yl}urea. Grades: 98%. CAS No. 938444-93-0. Molecular formula: C17H18N6O. Mole weight: 322.36. | |
| D2343 | D2343 is a dual inhibitor of β2-adrenoceptor and α1- adrenoceptor. Inhaled D2343 has a longer bronchodilating effect than terbutaline. Synonyms: 4-[1-hydroxy-2-[[4-(2-methoxyphenyl)-2-methylbutan-2-yl]amino]ethyl]phenol; D 2343; D2343; D-2343; N-(3-(2-methoxyphenyl)-1,1-dimethylpropyl)-1-(p-hydroxyphenyl)ethanolamine hydrochloride. CAS No. 72734-63-5. Molecular formula: C20H27NO3. Mole weight: 329.43. | |
| D609 | D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor and is antiviral and antitumor agent. It suppresses LPS- and IFNγ-induced NO production and blocks oxidative glutamate toxicity in nerve cells. Synonyms: D-609; D 609; D609; D-609 free. Grades: >98%. CAS No. 83373-60-8. Molecular formula: C11H15KOS2. Mole weight: 266.46. | |
| D-64131 | D-64131, under the IUPAC name (5-methoxy-1H-indol-2-yl)-phenylmethanone, is a 2-aroylindole derivative that inhibits tubulin polymerization. In vitro: Inhibits tumor cell proliferation (IC50 = 74 nM); In vivo: After oral administration, prevents tumor models growing in mice. Synonyms: 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; 1-(3,4,5-trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene; D-64131; 74588-78-6; (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE; CHEMBL140220; C16H13NO2; (5-methoxy-1H-indol-2-yl)-phenylmethanone; (5-Methoxy-1H-indol-2-yl)(phenyl)methanone; (5-Methoxy-1H-indol-2-yl)-phenyl-methanone; NCGC00025243-01; Tocris-1643; AC1N0QCR; 2-Benzoyl-5-methoxyindole; SCHEMBL5828518; CTK8F8930; DTXSID30397970; ICMIJSRDISNKOC-UHFFFAOYSA-N; HMS3268K07; ZINC2526466; 3570AH; BDBM50107658; AKOS022507157; CS-1008; 2-BENZOYL-5-METHOXY-1H-INDOLE; NCGC00025243-02; AN-25376; HE053371; HE187776; HY-15482; LS-83224; QC-11710; AB0165802; KB-208742; D64131; W-5310; BRD-K26997899-001-01-4; D-64131|(5-Methoxy-1H-indol-2-yl)phenylmethanone. CAS No. 74588-78-6. Molecular formula: C16H13NO2. Mole weight: 251.28. | |
| D77 | D77 is anti-HIV-1 inhibitor, which inhibits HIV-1(IIIB) replication (EC50=23.8 μM). Uses: Anti-hiv-1 inhibitor. Synonyms: D77; D 77; D-77; 4-[(5-Bromo-4-{(Z)-[2,4-dioxo-3-(2-oxo-2-phenylethyl)-1,3-thiazolidin-5-ylidene]methyl}-2-ethoxyphenoxy)methyl]benzoic acid. Grades: ≥98%. CAS No. 497836-10-9. Molecular formula: C28H22BrNO7S. Mole weight: 596.44. | |
| Dabrafenib Mesylate | Dabrafenib, also known as GSK2118436, is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. On May 29, 2013, FDA approved this drug. Synonyms: N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide methanesulfonate; Dabrafenib mesylate; GSK 2118436B; GSK2118436B; GSK-2118436B; GSK2118436 Methane sulfonate salt; Brand name: Taflinar. Grades: >98%. CAS No. 1195768-06-9. Molecular formula: C24H24F3N5O5S3. Mole weight: 615.67. | |
| Dacetuzmumab | Cas No. 880486-59-9. | |
| Dacinostat | Dacinostat, also known as LAQ824, is a hydroxamate histone deacetylase inhibitor with potential anticancer activity. LAQ824 sensitized nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. LAQ824 reduced clonogenic survival of the H23 and H460 cell lines five-fold compared with controls and four-fold compared with either agent alone (P<0.001). In phase I trials, LAQ824 was well tolerated at doses that induced accumulation of histone acetylation, with higher doses inducing changes consistent with HSP90 inhibition. Synonyms: NVP-LAQ824; NVP LAQ824; LAQ-824; LAQ824; LAQ 824; Dacinostat. CAS No. 404951-53-7. Molecular formula: C22H25N3O3. Mole weight: 379.46. | |
| Daclatasvir | Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV). Synonyms: Daclatasvir; BMS-790052; BMS 790052; BMS790052; EBP-883; EBP 883; EBP883; trade name Daklinza. Grades: 0.98. CAS No. 1009119-64-5. Molecular formula: C40H50N8O6. Mole weight: 738.89. | |
| Daclizumab | Daclizumab is a humanized monoclonal antibody of the human IgG1 isotype that binds specifically to the Tac epitope on the α-subunit (CD25) of the IL-2R. Synonyms: Zenapax; Ro 24-7375. CAS No. 152923-56-3. Molecular formula: C6332H9808N1678O1989S42. Mole weight: 142612.1. | |
| Dacomitinib Hydrate | Dacomitinib is a second-generation small molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) tyrosine kinase family (ErbB family) with potential anti-tumor activity. Uses: Tyrosine kinase inhibitors. Synonyms: PF-00299804; PF00299804; PF 00299804; PF299804. CAS No. 1042385-75-0. Molecular formula: C24H25ClFN5O2.H2O. Mole weight: 487.96. | |
| Dactolisib | Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BEZ235; BEZ-235; BEZ 235; NVPBEZ235; NVP-BEZ235; NVP-BEZ-235; NVP-BEZ 235; Dactolisib. Grades: 0.98. CAS No. 915019-65-7. Molecular formula: C30H23N5O. Mole weight: 469.548. | |
| [D-Ala2]-GIP (human) | A highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD. Synonyms: (D-Ala2)-Gastric Inhibitory Polypeptide (human); H-Tyr-D-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH; L-tyrosyl-D-alanyl-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-isoleucyl-L-histidyl-L-glutaminyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-asparagyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-glycyl-L-lysyl-L-lysyl-L-asparagyl-L-alpha-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparagyl-L-isoleucyl-L-threonyl-L-glutamine. Grades: ≥98% by HPLC. CAS No. 444073-04-5. Molecular formula: C226H338N60O66S. Mole weight: 4983.53. | |
| Danirixin | Danirixin is a small-molecule, selective, reversible, and non-peptide CXCR2 antagonist with high affinity (IC50 for CXCL8 binding = 12.5 nM). Synonyms: GSK1325756; GSK-1325756; GSK 1325756; Danirixin; N-(4-chloro-2-hydroxy-3-(3-piperidinylsulfonyl)phenyl)-N'-(3-fluoro-2-methylphenyl)urea. CAS No. 954126-98-8. Molecular formula: C19H21ClFN3O4S. Mole weight: 441.9. | |
| Danoprevir | Danoprevir(ITMN-191;R7227; RO5190591;RG7227) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Synonyms: RG7227; RG 7227; RG-7227; ITMN191; ITMN-191; ITMN 191; RO5190591; RO-5190591; RO 5190591. Grades: 0.98. CAS No. 850876-88-9. Molecular formula: C35H46FN5O9S. Mole weight: 731.837. | |
| Danshensu | Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. | |
| Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by blocking excitation-contraction coupling in the muscle fiber. Uses: Muscle relaxants, central. Synonyms: Dantrolene sodium salt; Dantrium; Sodium dantrolene. Grades: ≥99%. CAS No. 24868-20-0. Molecular formula: C14H9N4O5·7/2H2O·Na. Mole weight: 399.29. | |
| Danusertib | Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA-739358 binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division. Synonyms: PHA739358; PHA-739358; PHA 739358; Danusertib. CAS No. 827318-97-8. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
| D-AP5 | D-AP5, a more active form of AP5, has been found to be an NMDA antagonist. Synonyms: D-(-)-2-Amino-5-phosphonopentanoic acid. Grades: ≥99% by HPLC. CAS No. 79055-68-8. Molecular formula: C5H12NO5P. Mole weight: 197.13. | |
| D-AP7 | D-AP7 is a selective NMDA receptor antagonist that inhibits the glutamate binding site and activation of NMDA receptor. It is the 8-Bromo-cGMP and the more active form of DL-AP7. It shows anticonvulsant and anxiogenic-like effects. Synonyms: Heptanoic acid, 2-amino-7-phosphono-, (2R)-; D-AP7; D(-)-2-Amino-7-phosphonoheptanoic acid; (2R)-2-amino-7-phosphonoheptanoic acid. CAS No. 81338-23-0. Molecular formula: C7H16NO5P. Mole weight: 225.181. | |
| Dapiprazole | An alpha-adrenergic blocker. It is used in ophthalmic solutions to reverse mydriasis after eye examination. Synonyms: Dapiprazol; Glamidolo; Reversil. CAS No. 72822-12-9. Molecular formula: C19H27N5. Mole weight: 325.45. | |
| Daratumumab | Daratumumab is a recombinant IgG1k monoclonal antibody that binds to CD38 and leads to cell apoptosis. Daratumumab was granted orphan drug designation for the treatment of multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma. Uses: Antitumor agent. Synonyms: Darzalex; HuMax-CD38; UNII-4Z63YK6E0E. CAS No. 945721-28-8. Molecular formula: C6466H9996N1724O2010S42. Mole weight: 145391.67. | |
| [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: 1-Arg-5-Phe-7,9-Trp-11-Leu-substance P; D-Arg(10)-D-Phe(5)-D-Trp(7,9)-Leu(11)-SP; substance P, phenylalanyl(5)-tryptophyl(7,9)-leucine(11)-. CAS No. 96736-12-8. Molecular formula: C79H109N19O12. Mole weight: 1516.85. | |
| Darglitazone | Darglitazone is a thiazolidinedione (TZD) which is a proliferator-activated receptor γ (PPARγ) agonist. It increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations by increasing the expression of the p85 subunit of PI3K. Synonyms: CP 86325. Grades: ≥95%. CAS No. 141200-24-0. Molecular formula: C23H20N2O4S. Mole weight: 420.5. | |
| Darodipine | Darodipine, also known as PY 108-068, is an antagonist of calcium channel. Synonyms: diethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; darodipine; PY-108068; PY108068; PY108068; PY108-068; PY-108-068; PY 108-068; Darodipine. CAS No. 72803-02-2. Molecular formula: C19H21N3O5. Mole weight: 371.39. | |
| DASA-58 | DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. Synonyms: DASA-58; DASA 58; DASA58. Grades: 98%. CAS No. 1203494-49-8. Molecular formula: C19H23N3O6S2. Mole weight: 453.53. | |
| Dasatinib hydrochloride | Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor. It inhibits c-Kit (WT)/c-Kit (D816V). Synonyms: BMS-354825 hydrochloride; BMS 354825 hydrochloride; BMS354825 hydrochloride;Sprycel hydrochloride. Grades: >98%. CAS No. 854001-07-3. Molecular formula: C22H27Cl2N7O2S. Mole weight: 524.47. | |
| DAU 5884 hydrochloride | DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. It inhibits methacholine-dependent effects on cell proliferation and muscle contractility in bovine tracheal smooth muscle. Synonyms: DAU 5884 hydrochloride; DAU5884 hydrochloride; DAU-5884 hydrochloride; 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-oxo-1,4-dihydroquinazoline-3-carboxylate hydrochloride. Grades: ≥99% by HPLC. CAS No. 131780-48-8. Molecular formula: C17H21N3O3.HCl. Mole weight: 351.83. | |
| Dazucorilant | Dazucorilant is a glucocorticoid receptor antagonist. Synonyms: {(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)benzene-1-sulfonyl]-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl}(pyridin-2-yl)methanone; (R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl)(pyridin-2-yl)methanone. CAS No. 1496508-34-9. Molecular formula: C29H22F4N4O3S. Mole weight: 582.58. | |
| DB07268 | DB07268 is a potent and selective JNK1 inhibitor. It has some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Synonyms: DB07268; DB-07268; DB 07268. Grades: >98%. CAS No. 929007-72-7. Molecular formula: C17H15N5O2. Mole weight: 321.33. | |
| DBM 1285 dihydrochloride | DBM 1285 dihydrochloride is a p38 MAPK inhibitor supressing p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. It was shown to attenuate zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Synonyms: DBM 1285 dihydrochloride; DBM1285 dihydrochloride; DBM-1285 dihydrochloride; N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782532-29-9. Molecular formula: C21H22FN5S.2HCl. Mole weight: 468.42. | |
| DBPR108 | DBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus. Synonyms: DBPR-108; DBPR 108; DBPR108. Grades: >98%. CAS No. 1186426-66-3. Molecular formula: C16H25FN4O2. Mole weight: 324.39. | |
| DC 260126 | DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist that decreases intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. It was shown to lower serum insulin levels, improve insulin sensitivity and reduces the rate of apoptotic pancreatic β cells in obese diabetic (db/db) rats. Synonyms: DC 260126; DC260126; DC-260126; N-(4-Butylphenyl)-4-fluorobenzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 346692-04-4. Molecular formula: C16H18FNO2S. Mole weight: 307.38. | |
| DCB | DCB is an allosteric ligand for the metabotropic glutamate receptor mGlu5 that displays neutral modulation. It inhibits the modulation of mGlu5 by other allosteric modulators without affecting agonist-stimulated mGlu5 responses. Synonyms: [(3-Chlorophenyl)methylene]hydrazone-3-chlorobenzaldehyde; (E,E)-Bis[(3-chlorophenyl)methylidene]hydrazine. Grades: ≥98% by HPLC. CAS No. 6971-97-7. Molecular formula: C14H10Cl2N2. Mole weight: 277.15. | |
| DCEBIO | DCEBIO is a Ca2+ sensitive K+ channel (SKCa) agonist stimulating Cl- secretion via activation of hKCa3.1 (IK1) potassium channels and activation of an apical Cl- conductance. Synonyms: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one; Dichloro-EBIO. Grades: ≥99% by HPLC. CAS No. 60563-36-2. Molecular formula: C9H8Cl2N2O. Mole weight: 231.08. | |
| DCG IV | DCG IV is a potent group II mGluR agonist and a presynaptic depressant. Uses: Anticonvulsants. Synonyms: (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine; (1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 147782-19-2. Molecular formula: C7H9NO6. Mole weight: 203.15. | |
| d[Cha4]-AVP | d[Cha4]-AVP is a selective and potent human vasopressin V1B receptor agonist with Ki value of 1.2 nM. It stimulates corticosterone and ACTH secretion. It shows negligible vasopressor activity in vivo. Synonyms: 3-Mercaptopropionyl-Tyr-Phe-b-cyclohexyl-Ala-Asn-Cys-Pro-Arg-Gly-NH2; (Deamino-Cys¹,β-cyclohexyl-Ala?,Arg?)-Vasopressin. CAS No. 500170-27-4. Molecular formula: C50H71N13O11S2. Mole weight: 1094.31. | |
| DCPG | DCPG is a potent and selective mGlu8a agonist (EC50 = 31 nM) displaying > 100-fold selectivity over mGlu1-7. It increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Synonyms: (S)-3,4-DCPG; (S)-3,4-Dicarboxyphenylglycine; 4-[Amino(carboxy)methyl]phthalic acid. Grades: ≥98% by HPLC. CAS No. 201730-11-2. Molecular formula: C10H9NO6. Mole weight: 239.18. | |
| D-CPP-ene | D-CPP-ene has been found to be an effective and competitive NMDA antagonist. Synonyms: D-CPP-ene; SDZ-EAA 494; SDZ-EAA-494; SDZ-EAA494; Midafotel; D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid. Grades: ≥95% by HPLC. CAS No. 117414-74-1. Molecular formula: C8H15N2O5P. Mole weight: 250.19. | |
| DDP-38003 trihydrochloride | DDP-38003 trihydrochloride is the trihydrochloride salt of DDP-38003 which is a potent, selective, oral bioavailable irreversible inhibitor of KDM1A. Synonyms: DDP-38003 trihydrochloride; DDP 38003 trihydrochloride; DDP38003 trihydrochloride; N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methylpiperazin-1-yl)benzamide;trihydrochloride; DDP-38003 (trihydrochloride). Molecular formula: C21H29Cl3N4O. Mole weight: 459.84. | |
| DDR1-IN-1 hydrate | DDR-IN-1 has been shown to inhibit colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an IC50 value of 105 nM and an EC50 value of 87 nM. Synonyms: Discoidin Domain Receptor 1-IN-1. Grades: ≥95%. Molecular formula: C30H31F3N4O3·3/4H2O. Mole weight: 566.1. | |
| DDX3-IN-1 | DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor for HCV and HIV, respectively. Synonyms: DDX3-IN-1|1919828-83-3|CHEMBL4164410|SCHEMBL17978530|HY-121832|CS-0083520|1-[4-(4-methyltriazol-1-yl)phenyl]-3-(o-tolyl)urea|1-(2-methylphenyl)-3-[4-(4-methyltriazol-1-yl)phenyl]urea. Grades: 99.57%. CAS No. 1919828-83-3. Molecular formula: C17H17N5O. Mole weight: 307.35. | |
| Debio 0932 | Debio 0932, also known as CUDC-305, is a novel Hsp90 inhibitor with strong affinity for Hsp90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. Furthermore, Debio 0932 is able to extend animal survival in models of brain metastasis due to its ability to cross the blood-brain barrier, and it enhances the activity of several standard-of-care agents in animal models of cancer. Synonyms: Debio0932; Debio 0932; CUDC-305; CUDC305; CUDC 305. Grades: >98%. CAS No. 1061318-81-7. Molecular formula: C22H30N6O2S. Mole weight: 442.58. | |
| Debio-1347 | Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential for tumor cellular proliferation, differentiation and survival. Synonyms: Debio-1347; Debio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF-284; FF284; FF 284. CAS No. 1265229-25-1. Molecular formula: C20H16N6O. Mole weight: 356.389. | |
| Debromohymenialdisine | Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2, blocking G2 arrest. DBH also inhibits cyclin-dependent kinase 5/p25, protein tyrosine kinase 6, MAP kinase kinase 1, glycogen synthase kinase 3β and other kinases largely unrelated to DNA damage/repair and cell cycling. Synonyms: DBH; SKF 108753. Grades: ≥95%. CAS No. 75593-17-8. Molecular formula: C11H11N5O2. Mole weight: 245.2. | |
| Decamethonium Bromide | Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent. Uses: Neuromuscular depolarizing agents. Synonyms: Decamethonium; Decamethonum; Syncurine; DECAMETHONIUM ION; Lopac-D-1260; (DM)Br2. Grades: >98%. CAS No. 541-22-0. Molecular formula: C16H38N2.2Br. Mole weight: 418.29. | |
| (±)-Decanoylcarnitine chloride | Homolog of acetylcarnitine chloride and (±)-Acetylcarnitine chloride is a weak AChR (cholinergic) agonist. Synonyms: (+/-)-Decanoylcarnitine chloride; (3-carboxy-2-decanoyloxypropyl)-trimethylazanium chloride. Grades: ≥98% by HPLC. CAS No. 14919-36-9. Molecular formula: C17H34ClNO4. Mole weight: 351.91. | |
| Decloxizine hydrochloride | The hydrochloride salt form of Decloxizine, a hydroxyzine analogue, is a histamine 1 receptor antagonist and often known as an impurity of Hydroxyzine. Uses: The hydrochloride salt form of decloxizine is a histamine 1 receptor antagonist and often known as an impurity of hydroxyzine. Synonyms: 2-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]ethanol Hydrochloride; 1-[2-(2-Hydroxyethoxy)ethyl]-4-α-phenylbenzyldiethylenediamine Dihydrochloride; Autokar; Hydroxydiethylphenamine; Rescupal; UCB 1402; UCB1402; UCB-1402. Grades: 95%. CAS No. 13073-96-6. Molecular formula: C21H28N2O2?2ClH. Mole weight: 413.39. | |
| Defactinib hydrochloride | Defactinib HCl is a potent FAK phosphorylation inhibitor, overcoming YB-1-mediated paclitaxel resistance by an AKT-dependent pathway. Synonyms: N-Methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide monohydrochloride; Defactinib hydrochloride; Defactinib HCl; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878. Grades: >98%. CAS No. 1073160-26-5. Molecular formula: C20H22ClF3N8O3S. Mole weight: 546.95. | |
| Defensin HNP-2 (human) trifluoroacetate salt | Defensin HNP-2 is a peptide with antimicrobial properties that is secreted by human polymorphonuclear leukocytes (PMNs). Defensin HNP-2 binds to recombinant HIV-1 envelope glycoprotein gp120 and human CD4. Synonyms: DEFA2 Protein; α-Defensin 2; Human Neutrophil Peptide 2; Neutrophil Defensin 2. Grades: ≥95%. Molecular formula: C147H217N43O37S6·xCF3COOH. Mole weight: 3370.96. | |
| Degrasyn | Degrasyn, also known as WP1130, is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells and Hsp90/Hsp70 ratios within the cells. WP1130 was more effective in reducing leukemic versus normal hematopoietic colony formation and strongly inhibited colony formation of cells derived from patients with T315I mutant Bcr/Abl-expressing CML in blast crisis. WP1130 suppressed the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells transplanted into nude mice. WP1130 may be useful in treating CML. MM1: IC50 = 1 μM (human); U-266: IC50 = 1.3 μM (human); USP9X: IC50 = 3 μM (human); UCH-L1: IC50 = 3 μM (human); USP5: IC50 = 3 μM (human) In vitro: a partly selective DUB inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function; In vivo: suppressed the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells transplanted into nude mice. Synonyms: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide; 2-cyano-N-(1-phenylbutyl)-3-(6-bromopyridin-2-yl)acrylamide; degrasyn; WP1130; WP 1130; WP-1130; 856243-80-6; WP 1130; WP-1130; (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide; CHEMBL1923233; (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide; WP 1130, WP-1130, 856243-80-6; Degrasyn (WP1130); C19H18BrN3O. Grades: ≥ 98.0%. CAS No. 856243-80-6. Molecular formula: C23H25ClN2O4S. Mole weight: 460.97. | |
| Dehydroandrographolide | Dehydroandrographolide is a natural diterpenoid found in Andrographis paniculata. It possesses activity against hepatitis B virus DNA replication. Uses: Dehydroandrographolide is a natural diterpenoid found in andrographis paniculata and possesses activity against hepatitis b virus dna replication. Synonyms: Andrographolide, dehydro-; Deoxy-11,12-didehydroandrographolide; (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone; 14-Deoxy-11-dehydroandrographolide. Grades: >98%. CAS No. 134418-28-3. Molecular formula: C20H28O4. Mole weight: 332.43. | |
| Dehydroevodiamine hydrochloride | Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. Synonyms: 14-Methyl-8,14-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one hydrochloride; Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,14-dihydro-14-methyl-, hydrochloride (1:1); Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,14-dihydro-14-methyl-, monohydrochloride; 14-Methyl-7,8-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(14H)-one hydrochloride; Dehydroevodiamine chloride. Grades: ≥95%. CAS No. 111664-82-5. Molecular formula: C19H15N3O.HCl. Mole weight: 337.80. | |
| Delafloxacin | Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus. It has an anionic structure, which enhances its potency in acidic environments and in skin and soft tissue infections. Uses: Anti-infective agents. Synonyms: ABT-492; RX-3341; WQ-3034; Abt 492. Grades: 98%. CAS No. 189279-58-1. Molecular formula: C18H12ClF3N4O4. Mole weight: 440.8. | |
| Delanzomib | Delanzomib, also known as CEP-18770, is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Uses: Proteasome inhibitors. Synonyms: CEP18770; CEP 18770; CEP-18770; Delanzomib. CAS No. 847499-27-8. Molecular formula: C21H28BN3O5. Mole weight: 413.27. | |
| Delapril hydrochloride | Delapril Hydrochloride is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive effect. Synonyms: Alindapril hydrochloride; Delapril HCl; CV 3317; UNII-2SMM3M5ZMH. CAS No. 83435-67-0. Molecular formula: C26H33ClN2O5. Mole weight: 489. | |
| Delavirdine | Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1. Synonyms: U 90152; U90152; U-90152; BHAP-U 90152. Grades: >98%. CAS No. 136817-59-9. Molecular formula: C22H28N6O3S. Mole weight: 456.56. | |
| Deltarasin | Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. Synonyms: Deltarasin; 1440898-61-2; CHEMBL3286929; 1-benzyl-2-[4-[(2S)-2-(2-phenylbenzimidazol-1-yl)-2-piperidin-4-ylethoxy]phenyl]benzimidazole; 1440898-82-7; SCHEMBL15474539; BCP20971; EX-A1042; BDBM50019865; MFCD26793865; NSC779408; s7224; AKOS030526539; CCG-270204; CS-1611; NSC-779408; NCGC00378602-10; AC-32917; HY-15747; MS-30649; SW219816-1; J-690178; (S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole; 1-[(1S)-2-[4-(1-benzyl-1H-1,3-benzodiazol-2-yl)phenoxy]-1-(piperidin-4-yl)ethyl]-2-phenyl-1H-1,3-benzodiazole; 1-benzyl-2-{4-[(2S)-2-(2-phenyl-1H-1,3-benzodiazol-1-yl)-2-(piperidin-4-yl)ethoxy]phenyl}-1H-1,3-benzodiazole; O7T. Grades: >98%. CAS No. 1440898-61-2. Molecular formula: C40H37N5O. Mole weight: 603.75. | |
| Deltarasin hydrochloride | Small molecule inhibitor of the KRAS-PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS. Synonyms: Deltarasin hydrochloride. Grades: >98%. CAS No. 1440898-82-7. Molecular formula: C40H38ClN5O. Mole weight: 640.22. | |
| Deltorphin 2 | Deltorphin 2, an anion transporting peptid, is a selective peptide agonist for theδ opioid receptor. Synonyms: Deltorphin II; Deltorphin B; H-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2; L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-glutamyl-L-valyl-L-valyl-glycinamide. CAS No. 122752-16-3. Molecular formula: C38H54N8O10. Mole weight: 782.88. | |
| Demethylasterriquinone B1 | Demethylasterriquinone B1 is a nonpeptidyl fungal metabolite and has been found to be a selective IR activator. Synonyms: 2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione. Grades: ≥98% by HPLC. CAS No. 78860-34-1. Molecular formula: C32H30N2O4. Mole weight: 506.59. | |
| Denaverine hydrochloride | Denaverine hydrochloride is a phosphodiesterase inhibitor. Denaverine hydrochloride is applied in relaxation and delatation of birth canal in animals and spasms in humans for its anticholinergic effects. Uses: A phosphodiesterase inhibitor used for dilatation of the birth canal and spasms. Synonyms: 2-(dimethylamino)ethyl 2-(2-ethylbutoxy)-2,2-diphenylacetate; UNII-2AFK8FCD4R;Spasmalgan; Spasmalgan (TN); 2AFK8FCD4R. Grades: >98%. CAS No. 3321-06-0. Molecular formula: C24H34ClNO3. Mole weight: 419.99. | |
| Denufosol | An inhaled drug for the treatment of cystic fibrosis. Synonyms: [[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate. CAS No. 211448-85-0. Molecular formula: C18H27N5O21P4. Mole weight: 773.32. | |
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