BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| DMeOB | DMeOB is a negative allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor. It exhibits reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM). mGluR is the promising target for neurological disorder treatment. Synonyms: [(3-Methoxyphenyl)methylene]hydrazone-3-methoxybenzaldehyde; 3-Methoxybenzaldehyde. Grades: ≥98% by HPLC. CAS No. 40252-74-2. Molecular formula: C16H16N2O2. Mole weight: 268.31. |  |
| DMH2 | DMH2 is a type I bone morphogenetic protein (BMP) receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). It caused a decrease in cell growth and apoptosis of H1299 non-small cell lung carcinoma cells in vitro. Synonyms: DMH2; DMH-2; DMH 2; 4-[6-[4-[2- (4-Morpholinyl) ethoxy]phenyl]pyrazolo[1, 5-a]pyrimidin-3-yl]quinoline; 4-[2-[4-(3-quinolin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine. Grades: ≥98% by HPLC. CAS No. 1206711-14-9. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| DMH-25 | DMH-25, a chromene derivative, could be a covalent mTOR inhibitor that has be found to exhibit activity in restraining the growth and metastasis of triple-negative breast cancer cells. Synonyms: DMH25; DMH 25; 2H-1-Benzopyran, 6,8-dibromo-2-(4-bromophenyl)-3-nitro-; 6,8-Dibromo-2-(4-bromophenyl)-3-nitro-2H-1-benzopyran. Grades: 98%. CAS No. 1685280-21-0. Molecular formula: C15H8Br3NO3. Mole weight: 489.94. | |
| DMH4 | DMH4 is a selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I, respectively) with antiangiogenic activity in vitro and in vivo. Synonyms: 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyrimidine; 4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine. Grades: ≥98% by HPLC. CAS No. 515880-75-8. Molecular formula: C24H24N4O2. Mole weight: 400.47. | |
| DMOG | DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase. Synonyms: Dimethyloxalylglycine. Grades: >98%. CAS No. 89464-63-1. Molecular formula: C6H9NO5. Mole weight: 175.14. | |
| DMP 543 | DMP 543 is an acetylcholine release stimulator and a K-ATP channel blocker. It significantly enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). DMP 543 is a potential treatment of Alzheimer's diseases. Uses: Potential treatment of alzheimer's diseases. Synonyms: DMP-543; XR-543; DMP543; XR543; DMP 543; XR 543. 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone. Grades: ≥99% by HPLC. CAS No. 160588-45-4. Molecular formula: C26H18F2N2O. Mole weight: 412.44. | |
| DMP 777 | DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. Synonyms: L-694458; L 694458; L694458; DMP-777; DMP777. Grades: >98%. CAS No. 157341-41-8. Molecular formula: C31H40N4O6. Mole weight: 564.67. | |
| DMPQ dihydrochloride | DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). It displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C. Synonyms: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1123491-15-5. Molecular formula: C16H14N2O2.2HCl. Mole weight: 339.22. | |
| D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt | D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is the octapotassium salt of D-myo-Inositol-1,3,4,5-tetrakisphosphate, which is the phosphorylation product of inositol 1,4,5-trisphosphate and the enantiomer of the naturally-occurring D-myo-inositol 1,3,4,5-tetrakisphosphate. It is a potent inhibitor of Ins (1,4,5)P3 5-phosphatase with IC50 value of ~150 nM. It facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. It is a useful intermediate. Synonyms: L-myo-Inositol 1,3,4,5-(tetrakis)phosphate potassium salt. Grades: ≥98% by HPLC. CAS No. 145843-69-2. Molecular formula: C6H8O18P4K8. Mole weight: 804.73. | |
| D-myo-Inositol-1,3,4-triphosphate sodium salt | D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. Synonyms: D-myo-Inositol-1,3,5-triphosphate, sodium salt; 1,3,4-IP3 (sodium salt); 1,3,5-IP3 (sodium salt); HMS3650K09; Ins(1,3,5)P3 (sodium salt); Ins(1,3,4)-P3 (sodium salt); PD020265; D-myo-Inositol-1,3,4-triphosphate sodium salt. Grades: ≥98%. Molecular formula: C6H12Na3O15P3. Mole weight: 486.04. | |
| D-myo-Inositol-1,4,5-triphosphate potassium salt | D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium. Synonyms: D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE TRIPOTASSIUM SALT; tripotassium; [ (1R, 2S, 3R, 4R, 5S, 6R)-2, 3, 5-trihydroxy-4, 6-bis[[hydroxy (oxido)phosphoryl]oxy]cyclohexyl] hydrogen phosphate; D-Myo-inositol-1,2,5-tris(dihydrogen phosphate), tripotassium salt; PD020902; D-myo-Inositol 1,4,5-triphosphate tripotassium salt, >=95% (HPLC). Grades: ≥98%. CAS No. 141611-11-2. Molecular formula: C6H12O15P3·3K. Mole weight: 534.4. | |
| DNQX | DNQX is a selective non-NMDA receptor antagonist and could probably be useful in the treatment of Alzheimer's disease. Synonyms: 6,7-Dinitroquinoxaline-2,3-dione. Grades: ≥98% by HPLC. CAS No. 2379-57-9. Molecular formula: C8H4N4O6. Mole weight: 252.14. | |
| DNQX disodium salt | The sodium salt form of DNQX, which is a selective non-NMDA receptor antagonist and could probably be useful in the treatment of Alzheimer's disease. Synonyms: 6,7-Dinitroquinoxaline-2,3-dione disodium salt. Grades: ≥98% by HPLC. CAS No. 1312992-24-7. Molecular formula: C8H2N4O6Na2. Mole weight: 296.10. | |
| Docosatetraenoyl Ethanolamide | Docosatetraenoyl ethanolamide (DEA) is a potent endocannabinoid and anandamide analog containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors in microglia and binds to rat synaptosomal membranes (Ki = 34.4 nM). Synonyms: DEA; N-(2-hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide; 7,10,13,16-Docosatetraenylethanolamide; Adrenoyl-EA. Grades: ≥98%. CAS No. 150314-35-5. Molecular formula: C24H41NO2. Mole weight: 375.6. | |
| Dolasetron mesylate | The mesylate salt form of Dolasetron which is a pseudopelletierine derivative and could be used to relieve the nausea and vomiting caused by chemotherapy for behaving as a 5-HT3 receptor antagonist. Synonyms: Dolasetron methanesulfonate; Dolasetron mesilate. Grades: 98%. CAS No. 115956-13-3. Molecular formula: C19H20N2O3.CH4O3S. Mole weight: 420.48. | |
| Dolastatin 10 trifluoroacetate | Dolastatin 10 trifluoroacetate inhibits tubulin polymerization and induces tubulin aggregation in vitro. Synonyms: Dolastatin 10 trifluoroacetate; 2342568-65-2; EX-A8176; AKOS027470141; AKOS040745145; PD080063; Dolastatin 10 trifluoroacetate (110417-88-4 free base); (2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide; 2,2,2-trifluoroacetic acid; N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate. CAS No. 2342568-65-2. Molecular formula: C42H68N6O6S.CF3CO2H. Mole weight: 899.11. | |
| Donitriptan hydrochloride | The hydrochloride salt form of Donitriptan, which is a novel 5-HT derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors and could be probably used as an antimigraine agent. Synonyms: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazine hydrochloride; 4-[4-[2-[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]benzonitrile Hydrochloride. Grades: ≥98% by HPLC. CAS No. 170911-68-9. Molecular formula: C23H25N5O2.HCl. Mole weight: 439.94. | |
| Dopropidil | Dopropidil, also called as ORG 30701, is a cardioactive drug to be classified as a calcium antagonist with combined class I and class VI antiarrhythmic properties. Synonyms: 1-[1-(2-methylpropoxy)-3-(1-prop-1-ynylcyclohexyl)oxypropan-2-yl]pyrrolidine; 1- (1- ( (2-methylpropoxy) methyl) -2- ( (1- (1-propynyl) cyclohexyl) oxy) ethyl) pyrrolidine; 4205CERM; 4205CERM hydrochloride; CERM 4205; CERM4205; CERM-4205. CAS No. 79700-61-1. Molecular formula: C20H35NO2. Mole weight: 321.5. | |
| Dovitinib lactate | Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, RET, TrKA, and FLT3, and additionally targets FGFR (IC50 = 5 nM). Synonyms: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one;2-hydroxypropanoic acid; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate; Dovitinib(lactate); 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxy; CTK8B6779. CAS No. 692737-80-7. Molecular formula: C24H27FN6O4. Mole weight: 482.51. | |
| Doxapram | Doxapram is a respiratory stimulant with analeptic activity. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. It has been used as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease. Uses: Central nervous system stimulants; respiratory system agents. Synonyms: Dopram; 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one; Doxapramum; AHR-619; AHR 619; AHR619. Grades: ≥98%. CAS No. 309-29-5. Molecular formula: C24H30N2O2. Mole weight: 378.51. | |
| Doxazosin Mesylate | Doxazosin mesylate is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia. Grades: >98%. CAS No. 77883-43-3. Molecular formula: C24H29N5O8S. Mole weight: 547.58. | |
| DPCPX | DPCPX is an A1 adenosine receptor antagonist and could be useful in some physiological studies on cell cultures. Uses: Adenosine a1 receptor antagonists. Synonyms: 8-Cyclopentyl-1,3-dipropylxanthine. Grades: ≥99% by HPLC. CAS No. 102146-07-6. Molecular formula: C16H24N4O2. Mole weight: 304.39. | |
| DPH | DPH is a potent cell permeable c-Abl activator. It binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. DPH exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl and may be used in c-Abl tyrosine kinase-mediated cell signaling studies. Synonyms: 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione; 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione; MLS000036279; SMR000041163; 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione; Oprea1_189167; cid_660311; CHEMBL1311135; SCHEMBL13740728; BDBM66241; DTXSID30349772; HMS2301N21; DPH, >=98% (HPLC); AKOS002169217; AKOS016293917; CS-0251; NCGC00020328-05; HY-12070; F83225; A913925; 5-[3-(4-fluorophenyl)-1-phenyl-pyrazol-4-yl]hydantoin; 5-[3-(4-fluorophenyl)-1-phenyl-1h-pyrazol-4-yl]-2,4-imidazolidinedione; 5-[3-(4-fluorophenyl)-1-phenyl-4-pyrazolyl]imidazolidine-2,4-dione; 5-[3-(4-fluorophenyl)-1-phenyl-pyrazol-4-yl]imidazolidine-2,4-dione. Grades: >98%. CAS No. 484049-04-9. Molecular formula: C18H13FN4O2. Mole weight: 336.32. | |
| [D-Phe12]-Bombesin | [D-Phe12]-Bombesin is a bombesin receptor antagonist inhibiting bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Synonyms: [D-Phe12]-Bombesin; 12-Phe-bombesin; Bombesin, phe(12)-; PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-MET-NH2; Bombesin, phenylalanine(12)-; (D-Phe12)-Bombesin; Bombesin, 12-D-phenylalanine; AKOS024456850; PD079209. CAS No. 108437-87-2. Molecular formula: C74H112N22O18S. Mole weight: 1629.9. | |
| [D-Phe12,Leu14]-Bombesin | [D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist. It inhibits bombesin binding to rat brain (IC50 = 2 μM), inhibits amylase release in vitro (IC50 = 4 μM), and attenuates bombesin-mediated suppression of food intake in vivo. Synonyms: [D-Phe12,Leu14]-Bombesin; 108437-88-3; PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2; (D-Phe12,Leu14)-Bombesin; AKOS024457621; PD079499; HY-103287; CS-0027153. CAS No. 108437-88-3. Molecular formula: C75H114N22O18. Mole weight: 1610.9. | |
| DPNB-ABT 594 | DPNB-ABT 594 is nitrobenzyl-caged ABT 594, which is a selective α4β2 nAChR agonist. It is suitable for one- or two-photon photolysis. Synonyms: 5-(((2R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine. Grades: ≥98% by HPLC. Molecular formula: C31H46ClN3O11. Mole weight: 672.16. | |
| DPNI-caged-GABA | DPNI-caged-GABA, a kind of neurotransmitter, has been found to be allowed optical control of neural tissue with high spatial and temporal precision. Synonyms: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline. Grades: ≥98% by HPLC. CAS No. 927866-58-8. Molecular formula: C15H23N3O12P2. Mole weight: 499.30. | |
| DPPI 1c hydrochloride | The hydrochloride salt form of DPPI 1c, which has been found to be an inhibitor of DPP-IV and could improve glucose tolerance in diabetic mice. Synonyms: 1-[[[ (1-Hydroxymethyl) cyclopentyl]amino]acetyl]-2, 5-cis-pyrrolidinedicarbonitrile hydrochloride. Grades: ≥98% by HPLC. CAS No. 866396-70-5. Molecular formula: C14H20N4O2.HCl. Mole weight: 312.80. | |
| DPP-IV-IN-1 | A potent inhibitor of dipeptidyl peptidase IV (DPP-IV). Synonyms: 2-Pyrrolidinecarbonitrile, 4-fluoro-1-[2-[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]-, (2S,4S)-; (2S,4S)-4-fluoro-1-[2-[(1-hydroxy-2-methylpropan-2-yl)amino]acetyl]pyrrolidine-2-carbonitrile. CAS No. 625110-37-4. Molecular formula: C11H18FN3O2. Mole weight: 243.28. | |
| DPQ | DPQ is a potent inhibitor of poly(ADP-ribose) polymerases (PARPs), which is a family of enzymes that plays an important role in DNA repair and apoptosis in response to reactive oxygen and nitrogen species. DPQ inhibits PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: PARP Inhibitor III; 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone. Grades: ≥99%. CAS No. 129075-73-6. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| DPTIP | DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). DPTIP is metabolically stable and brain penetrant, regulating astrocyte-peripheral immune communication following brain inflammation. Synonyms: 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol. Grades: ≥98% by HPLC. CAS No. 351353-48-5. Molecular formula: C21H18N2O3S. Mole weight: 378.45. | |
| DQP 1105 | DQP 1105 has been found to be a NMDA receptor antagonist and could exhibit potential activities in the treatment of neurological disability. Synonyms: DQP-1105; DQP 1105; DQP1105; 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid. Grades: ≥97% by HPLC. CAS No. 380560-89-4. Molecular formula: C29H24BrN3O4. Mole weight: 558.42. | |
| DR 2313 | DR 2313 has been found to be a PARP-1/PARP-2 inhibitor and could exhibit neuroprotective avtivities as well as reduce cortical infarct volume in focal ischemia. Synonyms: 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one. Grades: ≥99% by HPLC. CAS No. 284028-90-6. Molecular formula: C8H10N2OS. Mole weight: 182.24. | |
| DR 4485 hydrochloride | The hydrochloride salt form of DR 4485, which has been found to be a 5-HT7 antagonist and is orally bioavailable. Synonyms: DR4485 HCl; DR4485 Hydrochloride; DR 4485 HCl; DR 4485 Hydrochloride; DR-4485 HCl; DR-4485 Hydrochloride; 6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride. Grades: ≥98% by HPLC. CAS No. 402942-53-4. Molecular formula: C26H28Cl2N2O.HCl. Mole weight: 491.88. | |
| Drinabant | Drinabant is a highly potent, selective antagonist for the CB1 receptor with Ki values of 0.16-0.44 nM. Uses: Cannabinoid receptor cb1 antagonists. Synonyms: AVE1625; AVE 1625; AVE-1625; Drinabant.N-[1-[bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide. Grades: ≥98%. CAS No. 358970-97-5. Molecular formula: C23H20Cl2F2N2O2S. Mole weight: 497.38. | |
| Drofenine hydrochloride | Drofenine hydrochloride is a widely used anticholinergic acts on smooth muscle to stop muscle spasms. Uses: A potent competitive inhibitor of bche. Synonyms: 2-(diethylamino)ethyl 2-cyclohexyl-2-phenylacetate;hydrochloride; α-Cyclohexyl-benzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride. Grades: ≥98%. CAS No. 548-66-3. Molecular formula: C20H32ClNO2. Mole weight: 353.93. | |
| Droxinostat | Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8. Droxinostat shows comparable inhibition of HDAC6 and HDAC8 (IC50 = 2.47 and 1.46 μmol/L, respectively). Synonyms: NS 41080; NS-41080; NS41080; 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide. CAS No. 99873-43-5. Molecular formula: C11H14ClNO3. Mole weight: 243.687. | |
| DS-1558 | This active molecular is a potent GPR40 agonist and it was found to have potent glucose lowering effects during an oral glucose tolerance test in animal models. DS-1558 improved hyperglycemia and increased insulin secretion dose-dependently during the oral glucose tolerance test in Zucker fatty rats. Uses: Improve hyperglycemia and increase insulin secretion. Synonyms: DS-1558; DS 1558; DS1558; (S)-3-ethoxy-3-(4-(((R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl)oxy)phenyl)propanoic acid. Grades: 98%. CAS No. 1202575-67-4. Molecular formula: C21H21F3O4. Mole weight: 394.39. | |
| DS16570511 | DS16570511 is an inhibitor of the mitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+ influx. It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). Synonyms: 4-(3-(3-(((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methyl)amino)benzoyl)-1H-indol-1-yl)butanoic acid. Grades: ≥95%. Molecular formula: C30H25Cl2N3O4. Mole weight: 562.44. | |
| DS2 | DS2 has been found to be a positive allosteric modulator of δ-GABAA receptors and could probably be useful against analgesics as well as sleep disorders. Synonyms: DS2; DS-2; DS 2; 4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide. Grades: ≥97% by HPLC. CAS No. 374084-31-8. Molecular formula: C18H12ClN3OS. Mole weight: 353.83. | |
| DS-2248 | DS-2248 is an orally active and small molecule inhibitor of Hsp90, with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor DS-2248 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may result in an inhibition of tumor cell proliferation. Synonyms: DS2248; DS-2248; DS 2248. Grades: >98%. CAS No. 1696408-04-4. | |
| DSP-4 | DSP-4 has been found to be an adrenergic neurotoxin and could exhibit neurotoxic effects on both peripheral and central noradrenergic neurons. Synonyms: DSP-4; DSP 4; DSP4; N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 40616-75-9. Molecular formula: C11H15BrClN.HCl. Mole weight: 313.06. | |
| [D-Trp34]-Neuropeptide Y | [D-Trp34]-Neuropeptide Y is a potent and selective NPY Y(5) receptor agonist (pEC50= 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively), with > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Unlike the prototype selective NPY Y(5) receptor agonist [D-Trp(32)]NPY, [D-Trp(34)]NPY markedly increases food intake in rats, an effect that is blocked by the selective NPY Y(5) receptor antagonist CGP 71683A. Synonyms: Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-D-Trp-Arg-Tyr-NH2. CAS No. 153549-84-9. Molecular formula: C196H289N55O56. Mole weight: 4311.77. | |
| [D-Trp 7,9,10]-Substance P | [D-Trp 7,9,10]-Substance P is a substance P analog that blocks activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors. Synonyms: Gpantagonist-2A; GPAnt-2 analog. CAS No. 89430-38-6. Molecular formula: C79H105N21O13S. Mole weight: 1588.89. | |
| [D-Trp8]-γ-MSH | [D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50= 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). It displays antiinflammatory efficacy in mice bearing a non-functional MC1R (recessive yellow e/e mouse) and these effects are abrogated in the presence of the HO-1 inhibitor ZnPPIX. Synonyms: L-tyrosyl-L-valyl-L-methionyl-glycyl-L-histidyl-L-phenylalanyl-L-arginyl-D-tryptophyl-L-alpha-aspartyl-L-arginyl-L-phenylalanyl-glycine. CAS No. 321351-81-9. Molecular formula: C74H99N21O16S. Mole weight: 1570.79. | |
| DU125530 | DU125530 is a selective 5-HT1A receptor antagonist (Ki = 0.7 nM). DU125530 has the potential to be used in the treatment of anxiety, depression and psychiatric disorders. Synonyms: DU-125530; DU125530; DU 125530; 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]butyl]-1,1-dioxo-1,2-benzothiazol-3-one. Grades: 99%. CAS No. 161611-99-0. Molecular formula: C23H26ClN3O5S. Mole weight: 491.99. | |
| DUBs-IN-1 | DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor for USP7/USP8. Synonyms: DUBs-IN-1; DUBs IN 1. Grades: >98%. CAS No. 924296-18-4. Molecular formula: C20H11N5O. Mole weight: 337.33. | |
| DUBs-IN-2 | DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor for USP7/USP8. Synonyms: DUBs IN 2. Grades: >98%. CAS No. 924296-19-5. Molecular formula: C15H9N5O. Mole weight: 275.26. | |
| DUBs-IN-3 | DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor for USP8. It is 30 fold selectivity over USP7. Synonyms: DUBs-IN-3; DUBs IN 3. Grades: >98%. CAS No. 924296-17-3. Molecular formula: C16H9N5O. Mole weight: 287.28. | |
| durvalumab | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody. It was approved by FDA for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy, or whose disease has progressed within 12 months of receiving platinum-containing chemotherapy before or after surgery. Uses: The treatment of locally advanced or metastatic urothelial carcinoma. Synonyms: Imfinzi. CAS No. 1428935-60-7. Molecular formula: C6502H10018N1742O2024S42. Mole weight: 146.3. | |
| Dutogliptin | Dutogliptin is a selective and orally active DPP4 inhibitor. It can improve glycaemic control in patients with type 2 diabetes. But phase III clinical trials for the treatment of type 2 diabetes were discontinued. Uses: Type 2 diabetes mellitus. Synonyms: PHX 1149; PHX1149; PHX-1149; (2R)-1-(((3R)-Pyrrolidin-3-ylamino)acetyl)pyrrolidin-2-yl)boronic acid;890402-81-0 (tartrate salt). Grades: 98%. CAS No. 852329-66-9. Molecular formula: C10H20BN3O3. Mole weight: 241.10. | |
| Duvelisib R enantiomer | The R isomer analogue of Duvelisib which is a high selective PI3K δ/γ inhibitor. Uses: The r isomer analogue of duvelisib which is a high selective pi3k δ/γ inhibitor. Synonyms: IPI-145 R enantiomer; IPI 145 R enantiomer; IPI145 R enantiomer; INK1197 R enantiomer; INK 1197 R enantiomer; INK-1197 R enantiomer. Grades: 95%. CAS No. 1261590-48-0. Molecular formula: C22H17ClN6O. Mole weight: 416.86. | |
| DV 7028 hydrochloride | The hydrochloride salt form of DV 7028, which has been found to be a 5-HT2A receptor antagonist and could restrain collagen-induced serotonin secretion and platelet aggregation. Synonyms: DV 7028 hydrochloride; DV7028 hydrochloride; DV-7028 hydrochloride; 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione hydrochloride. Grades: ≥99% by HPLC. CAS No. 133364-62-2. Molecular formula: C21H25FN4O3.HCl. Mole weight: 436.91. | |
| DW532 | DW532 is one of simplified analogues of hematoxylin that has been reported to have a broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity. IC50 value for EGFR inhibition was 4.9 μmol/L and for 5.5 μmol/L for VEGFR2 inhibition. It also suppressed their downstream signaling. DW532 inhibited tubulin polymerization dose-dependently via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. Moreover, treatment with DW532 potently and dose-dependently suppressed angiogenesis in vitro and in vivo. Uses: Anti-cancer. Synonyms: DW532; DW-532; DW 532. 7,8-dihydroxy-4-(3-hydroxy-4-methoxyphenyl)-2H-chromen-2-one. Grades: 98%. CAS No. 1267949-42-7. Molecular formula: C16 H12 O6. Mole weight: 300.26. | |
| DY131 | DY131 is a novel selective agonist of ERRβ and ERRγ, which displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. It could potentiate the ERRγ-induced growth inhibition in DU145- ERRγ and LNCaP- ERRγ prostate cancer cells in a dose-dependent manner. It inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. It had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). It appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. It has been demonstrated an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer. Uses: Dy131 has been demonstrated an antiproliferative/tumor-suppressing function for errγ in prostate cancer. Synonyms: N-[ (E) -[4- (diethylamino) phenyl]methylideneamino]-4-hydroxybenzamide; GSK4716; GW4716; GW574716; DY131; DY-131; DY 131; GSK-9089; GSK 9089; GSK9089. Grades: >99 %. CAS No. 95167-41-2. Molecular formula: C18H21N3O2. Mole weight: 311.38. | |
| DY-268 | DY-268, a pyrazol carboamide derivative, has been found to be a FXR antagonist that could be significant in studies of the biological activities of FXR. IC50: 7.5 nM. Synonyms: SCHEMBL16974048; MolPort-039-338-073; BDBM50015421; DY-268; DY 268; DY268; AKOS027470244; 1-[(3-methoxyphenyl)methyl]-N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-3-(4-methylphenyl)pyrazole-4-carboxamide. Grades: 98%. CAS No. 1609564-75-1. Molecular formula: C30H32N4O5S. Mole weight: 560.67. | |
| Dynorphin B (1-9) trifluoroacetate salt | Dynorphin B (1-9) is a neuropeptide and N-terminal cleavage product of dynorphin B. Dynorphin B (1-9) is a competitive inhibitor of dynorphin A (1-9). Grades: ≥95%. Molecular formula: C54H78N16O12·xCF3COOH. Mole weight: 1143.30. | |
| E17110 | E17110 is an LXRβ agonist. E17110 shows a significant activation effect on LXRβ, with an EC50 of 0.72 μmol/L. Synonyms: E-17110; E 17110. Grades: ≥98% by HPLC. Molecular formula: C16H15FN2O5. Mole weight: 334.30. | |
| E 2012 | E 2012, is a potent selective, orally bioavailable γ-secretase modulator without affecting Notch processing that can used to treat Alzheimer's Disease. Synonyms: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one; 870843-42-8; E 2012; (E)-1-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-3-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZYLIDENE]PIPERIDIN-2-ONE; UNII-3LSD4Y5F0F; 3LSD4Y5F0F; CHEMBL1224151; E-2012; (e)-1-((1s)-1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1h-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-((1S)-1-(4-Fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; GTPL7358; SCHEMBL1238634; SCHEMBL1238639; C25H26FN3O2; DTXSID30468614; PUOAETJYKQITMO-LANLRWRYSA-N; (S,E)-1-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; W-5462; J-501810; I14-15434; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylene]piperidin-2-one; 2-Piperidinone, 1-((1S)-1-(4-fluorophenyl)ethyl)-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)methylene)-, (3E)-. CAS No. 870843-42-8. Molecular formula: C25H26FN3O2. Mole weight: 419.49. | |
| E2609 | | |
| E 3810 dihydrochloride | E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, -2, and -3 and FGFR-1 and -2 kinases in the nanomolar range. Uses: Antitumor agent. Synonyms: E 3810 dihydrochloride; E3810 dihydrochloride; E-3810 dihydrochloride; Lucitanib dihydrochloride; 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide dihydrochloride. Grades: 99%. CAS No. 2108875-91-6. Molecular formula: C26H25N3O4.2HCl. Mole weight: 516.42. | |
| E4CPG | E4CPG is a group I/group II metabotropic glutamate receptor antagonist with higher potency than (RS)-MCPG. Synonyms: (RS)-α-Ethyl-4-carboxyphenylglycine; 4-(1-amino-1-carboxypropyl)benzoic acid. Grades: ≥99% by HPLC. CAS No. 170846-89-6. Molecular formula: C11H13NO4. Mole weight: 223.23. | |
| (E)-(4S,6S)-8-Methyl-6-((S)-3-methyl-2-{(S)-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-propionylamino}-butyrylamino)-5-oxo-4-((R)-2-oxo-pyrrolidin-3-ylmethyl)-non-2-enoic acid benzyl ester | A SARS-CoV inhibitor. Synonyms: Benzyl (E, 4S) -4- [ [ (2S) -4-methyl-2- [ [ (2S) -3-methyl-2- [ [ (2S) -2- [ (5-methyl-1, 2-oxazole-3-carbonyl) amino] propanoyl] amino] butanoyl] amino] pentanoyl] amino] -5- [ (3S) -2-oxopyrrolidin-3-yl] pent-2-enoate. Molecular formula: C35H48N6O8. Mole weight: 680.8. | |
| E 5555 hydrobromide | E 5555 hydrobromide is a potent and orally bioactive thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50 = 19 nM). It inhibits human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively. Synonyms: Atopaxar hydrobromide; ER 172594-06 HBr; E 5555 hydrobromide; E-5555 hydrobromide; E5555 hydrobromide. Grades: 99%. CAS No. 474550-69-1. Molecular formula: C29H38FN3O5.HBr. Mole weight: 608.54. | |
| E6446 | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E6446; E 6446; E-6446; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazoleBMS-790052; EBP 883; BMS 790052; EBP883; BMS790052; EBP-883; BMS-790052. CAS No. 1219925-73-1. Molecular formula: C27H35N3O3. Mole weight: 449.59. | |
| E7449 | E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2, which enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. Synonyms: E7449; E 7449; E-7449; 2X-121; 2X 121; 2X121. Grades: >98%. CAS No. 1140964-99-3. Molecular formula: C18H15N5O. Mole weight: 317.34. | |
| EA4 | EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grades: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8. | |
| Eact | Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Eact also stimulates transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). Stimulates submucosal gland secretion in human bronchi. Synonyms: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide. Grades: ≥99% by HPLC. CAS No. 461000-66-8. Molecular formula: C22H24N2O5S. Mole weight: 428.5. | |
| EB 47 dihydrochloride | EB 47 dihydrochloride is a PARP-1 inhibitor (IC50 = 45 nM) that reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. Synonyms: EB 47 dihydrochloride; EB47 dihydrochloride; EB-47 dihydrochloride; 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1190332-25-2. Molecular formula: C24H27N9O6.2HCl. Mole weight: 610.45. | |
| EBI-2511 | EBI-2511 is a highly potent and orally active EZH2 inhibitor (IC50 = 4 nM). Synonyms: EBI2511; N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl(tetrahydro-2H-pyran-4- yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide. Grades: ≥98%. CAS No. 2098546-05-3. Molecular formula: C34H48N4O4. Mole weight: 576.77. | |
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