BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| FGFR4-IN-1 | FGFR4-IN-1 is a potent and selective FGFR4 inhibitor with potential for the treatment of gastric cancer. Synonyms: N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide; FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1. CAS No. 1708971-72-5. Molecular formula: C24H27N7O5. Mole weight: 493.52. |  |
| FGIN-1-27 | FGIN-1-27 is a high affinity agonist of mitochondrial benzodiazepine receptors (PBR) binding to benzodiazepine receptors on mitochondrial membranes. FGIN-1-27 indirectly potentiates GABAA receptor signaling to exhibit anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models. Synonyms: FGIN-1-27; FGIN 1 27; FGIN-1 27; FGIN 1-27; FGIN127; N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide; 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide. Grades: ≥98% by HPLC. CAS No. 142720-24-9. Molecular formula: C28H37FN2O. Mole weight: 436.61. | |
| FGIN-1-43 | FGIN-1-43 is a potent and specific ligand for the mitochondial DBI receptor (MDR). Synonyms: FGIN-1-43; FGIN 1 43; FGIN 1-43; FGIN-1 43; FGIN143; N,N-Dihexyl-2-(4-chlorophenyl)-5-chloroindole-3-acetamide; 2-[5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide. Grades: ≥98%. CAS No. 145040-29-5. Molecular formula: C28H36Cl2N2O. Mole weight: 487.51. | |
| FH535 sodium salt | FH535 sodium salt is a dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, leading to the inhibition of proliferation and motility of multiple cancer cells. Synonyms: FH535 sodium salt; FH 535 sodium salt; FH-535 sodium salt; (2,5-dichlorophenyl)sulfonyl-(2-methyl-4-nitrophenyl)azanide sodium salt. Grades: 99%. Molecular formula: C13H9Cl2N2NaO4S. Mole weight: 383.18. | |
| Fibroblast Growth Factor | Fibroblast Growth Factors are a family of cell signalling proteins produced by macrophages, consisting of 23 members in humans. They have various functions so that is involved in multiple processes, regulating fundamental developmental pathways. Synonyms: FGF. | |
| FICT-FF-FMK | FICT-FF-FMK is a fluorescein isothiocyanate (FITC)-conjugated inhibitor of cathepsin B and cathepsin L, which can be used for detecting cathepsin B and cathepsin L in live cells. Synonyms: FICT-Phe-Phe-FMK; FICT-Phe-Phe-Fluoromethylketone. Grades: >95%. Molecular formula: C41H34FN3O6S. Mole weight: 715.80. | |
| Fiduxosin | Fiduxosin is a potent antagonist of α1-adrenoceptor, with Ki= 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively. Fiduxosin was found to have improved uroselectivity relative to tamsulosin. Synonyms: 3-[4-[(3aR,9bR)-9-methoxy-3,3a,4,9b-tetrahydro-1H-chromeno[3,4-c]pyrrol-2-yl]butyl]-8-phenyl-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione; 3-(4-(9-methoxy-1,2,3,3a,4,9b-hexahydro(1)benzopyran(3,4-c)pyrrol-2-yl)butyl)-8-phenylpyrazino(2',3'-4,5)thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione; ABT 980; ABT-980; ABT980; fiduxosin. CAS No. 208993-54-8. Molecular formula: C30H29N5O4S. Mole weight: 555.65. | |
| Fiduxosin hydrochloride | Fiduxosin hydrochloride is an alpha(1)-adrenoceptor antagonist used for the treatment of benign prostatic hyperplasia. Synonyms: 3-[4-[(3aR,9bR)-9-methoxy-3,3a,4,9b-tetrahydro-1H-chromeno[3,4-c]pyrrol-2-yl]butyl]-8-phenyl-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione;hydrochloride; Fiduxosin hydrochloride; Fiduxosin HCl; 208993-54-8 (Fiduxosin) ; 208992-74-9 ( Fiduxosin Hydrochlride). Grades: >98%. CAS No. 208992-74-9. Molecular formula: C30H29N5O4S.HCl. Mole weight: 592.11. | |
| FIIN-2 | FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. Synonyms: FIIN2; FIIN 2; FIIN-2. Grades: 98%. CAS No. 1633044-56-0. Molecular formula: C35H38N8O4. Mole weight: 634.73. | |
| FIIN-3 | FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. Synonyms: FIIN3; FIIN 3; FIIN-3. Grades: 98%. CAS No. 1637735-84-2. Molecular formula: C34H36Cl2N8O4. Mole weight: 691.61. | |
| Filaminast | Filaminast is a Type 4 cyclic nucleotide phosphodiesterase inhibitor. It is an analog of rolipram which served as a prototype molecule for several development efforts. In Oct 1999, phase II clinical trials for Asthma in European Union was discontinued. Uses: Asthma. Synonyms: UNII-CDD69JC61J; Way-pda-641; WAY-PDA 641; WAY-PDA-641; CDD69JC61J; SCHEMBL73843; 1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime. Grades: 98%. CAS No. 141184-34-1. Molecular formula: C15H20N2O4. Mole weight: 292.33. | |
| Filanesib | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grades: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. | |
| Filorexant | Filorexant, a selective reversible and orally bioavaliable antagonist of OX(1)R receptor and OX(2)R receptor, could probably be an effective compound in the treatment of insomnia. It is still under the Phase II trial by Merck. Binding Ki: less than 3 nM. Uses: Filorexant, a selective reversible and orally bioavaliable antagonist of ox(1)r receptor and ox(2)r receptor, could probably be an effective compound in the treatment of insomnia. Synonyms: FILOREXANT; MK-6096; UNII-E6BTT8VA5Z; MK6096; MK 6096. Grades: 98%. CAS No. 1088991-73-4. Molecular formula: C24H25FN4O2. Mole weight: 420.48. | |
| Finasteride acetate | Finasteride acetate is a specific inhibitor of 5α-reductase. Finasteride can be used in the treatment of men with benign prostatic, and through the assessment of the long-term safety and efficacy of finasteride hyperplasia (BPH) it was well tolerated, wit. Synonyms: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide;acetic acid Finasteride (acetate). CAS No. 222989-99-3. Molecular formula: C25H40N2O4. Mole weight: 432.60. | |
| Fipexide | Fipexide hydrochloride is a nootropic agent that displays a positive effect on cognitive function. Uses: A nootropic drug, mainly for the treatment of senile dementia. Synonyms: 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone. Grades: ≥98%. CAS No. 34161-24-5. Molecular formula: C20H21ClN2O4. Mole weight: 388.85. | |
| FIPI hydrochloride | FIPI hydrochloride is an inhibitor of phospholipase D (PLD) (IC50 values of 20-25 nM for both PLD1 and PLD2), which is an enzyme catalyzing the hydrolysis of phosphatidylcholine to form phosphatidic acid. FIPI blocks in vivo phosphatidic acid (PA) production with subnanomolar potency. FIPI is a candidate therapeutic for autoimmunity and cancer metastasis. Uses: Potential treatment of autoimmunity and cancer metastasis. Synonyms: AOB33782; AKOS024457709; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride; 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1781834-93-2. Molecular formula: C23H24FN5O2.HCl. Mole weight: 457.93. | |
| FITM | FITM is a potent mGlu1 inhibitor (Ki = 2.5 nM) with great selectivity that does not disrupt mGlu5. Synonyms: Benzamide, 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)?amino]?-4-pyrimidinyl]?-2-thiazolyl]?-; 4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide; 4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide. CAS No. 932737-65-0. Molecular formula: C18H18FN5OS. Mole weight: 371.43. | |
| FK-330 | FK-330 is a novel inducible nitric oxide synthase inhibitor for preventing ischemia and reperfusion injury in rat liver transplantation. Uses: A novel inducible nitric oxide synthase inhibitor. Synonyms: FK-330; FK 330; FK330; 2-Pyridinepropanamide, alpha-(((2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl)amino)-N-(2-oxo-2-(4-((6-(trifluoromethyl)-4-pyrimidinyl)oxy)-1-piperidinyl)ethyl)-, (alphaS)-. Grades: ≥98%. CAS No. 442198-67-6. Molecular formula: C29H28ClF3N6O4. Mole weight: 617.02. | |
| FK 866 hydrochloride | FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, visfatin, PBEF1) (Ki = 0.3 nM) and inhibits NAD biosynthesis. It induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM)and induces apoptosis in four different neuroblastoma cell lines. FK 866 exhibits antineoplastic and antiangiogenic activities. Synonyms: FK-866 Hydrochloride; FK 866 Hydrochloride; FK866 Hydrochloride; 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 2727965-45-7. Molecular formula: C24H29N3O2.HCl. Mole weight: 427.97. | |
| FK 960 | FK 960 is a somatostatin receptor agonist and a 5-HT agonist activating both serotonin and somatostatin production as a cognitive enhancer. The phase II clinical trial for the treatment of Alzheimer's disease is discontinued. Synonyms: FK-960; FK 960; FK960; 60MMJ100ZX; N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide. Grades: 99%. CAS No. 133920-70-4. Molecular formula: C13H16FN3O2. Mole weight: 265.28. | |
| FK962 | FK962 is an enhancer of somatostatin release, with cognitive enhancement and anti-dementia activity. Synonyms: FK-962; N-[1-Acetylpiperidin-4-Yl]-4-Fluorobenzamide. Grades: 98%. CAS No. 283167-06-6. Molecular formula: C14H17FN2O2. Mole weight: 264.29. | |
| FKGK 11 | FKGK 11 is a potent and selective inhibitor of iPLA2 with an XI(50) value of 0.0073. In contrast, it dispalys little or no inhibition against GIVA cPLA2 (XI(50) >0.91). Synonyms: 1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone. Grades: ≥98%. CAS No. 1071000-98-0. Molecular formula: C13H13F5O. Mole weight: 280.2. | |
| FKGK 18 | FKGK 18 is a potent and selective inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It displays 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2). Synonyms: 1,1,1-trifluoro-6-(2-naphthalenyl)-2-hexanone. Grades: ≥95%. CAS No. 1071001-09-6. Molecular formula: C16H15F3O. Mole weight: 280.3. | |
| Flavoxate HCL | Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors. Uses: Parasympatholytics. Synonyms: NSC-114649; NSC 114649; NSC114649. Grades: >98%. CAS No. 3717-88-2. Molecular formula: C24H25NO4.HCl. Mole weight: 427.92. | |
| Flecainide Acetate | Flecainide Acetate is an antiarrhythmic as a Na+ channel blocker that inhibits fast Na+ current in cardiac muscle. Synonyms: Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, acetate (1:1); Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate; (±)-Flecainide acetate; 2,5-Bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide acetate; Almarytm; Apocard; Ecrinal; R 818; R 818 (pharmaceutical); Tambocor. Grades: ≥98%. CAS No. 54143-56-5. Molecular formula: C19H24F6N2O5. Mole weight: 474.40. | |
| Flibanserin | Flibanserin, a benzimidazole derivative, has been found to be a Serotonin 1A/2A receptor agonist that was once studied as antidepressant as well as anxiolytic agent and could be used against female sexual dysfunction. Synonyms: EBD6396; EBD 6396; EBD-6396; Flibanserin;Bimt 17;3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one. Grades: 98%. CAS No. 167933-07-5. Molecular formula: C20H21F3N4O. Mole weight: 390.40. | |
| Flibanserin hydrochloride | Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that was developed for the treatment of hypoactive sexual desire disorder in women. Synonyms: 3-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-1H-benzimidazol-2-one;hydrochloride; 3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one;hydrochloride. CAS No. 147359-76-0. Molecular formula: C20H22ClF3N4O. Mole weight: 426.86. | |
| Flindokalner | Flindokalner, an anxiolytic agent, is a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Flindokalner can be also used to treat stroke. Synonyms: (3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one; (5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one; BMS 204352; BMS-204352; BMS204352; MaxiPost. Grades: >98%. CAS No. 187523-35-9. Molecular formula: C16H10ClF4NO2. Mole weight: 359.7. | |
| FLT3-IN-1 | FLT3-IN-1, a Flt3 inhibitor, has been found to have week activity against T lymphoma Jurkat cells and human lung cancer PC-9 and H292 cells. IC50: 10 nM (in vitro). Uses: Flt3-in-1 is a flt3 inhibitor that has been found to have week activity against t lymphoma jurkat cells and human lung cancer pc-9 and h292 cells. Synonyms: SKLB4771; SKLB-4771; SKLB 4771. FLT3-IN-1; FLT3-IN1; FLT3-IN 1; CHEMBL2046883; SKLB4771; AOB5016; AOB 5016; AOB-5016. Grades: 97%. CAS No. 1370256-78-2. Molecular formula: C25H27N7O3S2. Mole weight: 537.66. | |
| FLT3 Inhibitor III | FLT3 Inhibitor III, a cell-permeable 5-phenyl-2-thiazolamine compound, is a potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) with an IC50 of 50 nM. It displays high selectivity for FLT3 over a panel of 300 other kinases. Synonyms: Fms-like Tyrosine Kinase Inhibitor III; (5-Phenyl-thiazol-2-yl)-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-amine; 5-Phenyl-N-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-thiazolamine; 5-Phenyl-N-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-thiazolamine; (5-Phenyl-thiazol-2-yl)-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-amine. Grades: ≥98%. CAS No. 852045-46-6. Molecular formula: C21H23N3OS. Mole weight: 365.5. | |
| Fluconazole hydrate | Fluconazole (hydrate) is the hydrate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10(-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h. Synonyms: UK 49858 hydrate; UK49858 hydrate; UK-49858 hydrate. Grades: >98%. CAS No. 155347-36-7. Molecular formula: C13H14F2N6O2. Mole weight: 324.29. | |
| Fluconazole mesylate | Fluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10(-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h. Synonyms: UK 49858 mesylate; UK49858 mesylate; UK-49858 mesylate. Grades: >98%. CAS No. 159532-41-9. Molecular formula: C14H16F2N6O4S. Mole weight: 402.38. | |
| Fludalanine | Fludalanine, an analogue of D-alanine that irreversibly inactivates the racemase, inhibits the synthetase. Uses: Antibacterial. Synonyms: MK641; MK641; MK641; Fludalanine; 3-Fluoro-D-(2-2H)alanine;(S)-2-amino-3-fluoropropanoic-2-d acid. Grades: ≥98%. CAS No. 35523-45-6. Molecular formula: C3H6FNO2. Mole weight: 108.09. | |
| Flufenamic acid | Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. Synonyms: Flufenamic Acid; CI-440; CN-27554; INF-1837; CI 440; CN 27554; INF 1837; CI440; CN27554; INF1837. Grades: >98%. CAS No. 530-78-9. Molecular formula: C14H10F3NO2. Mole weight: 281.23. | |
| Flumatinib | Flumatinib is a multi-kinase inhibitor of c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2 nM, 307.6 nM and 2662 nM respectively. It can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell in vitro. It can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell in higher concentration. It has no or little effect on other tyrosine kinase including EGFR?KDR?c-Src andHER2. It can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. It effectively overcame the drug resistance of certain KIT mutants with activation loop mutations. It was developed by Jiangsu Hansoh Pharmaceutical Co., Ltd. and is currently in Phase III clinical trials in China for the treatment of chronic myelogenous leukemia (CML). Uses: Flumatinib is used for the treatment of chronic myelogenous leukemia (cml). Synonyms: 4-[(4-methylpiperazin-1-yl)methyl]-N-(6-methyl-5-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}pyridin-3-yl)-3-(trifluoromethyl)benzamide; HH-GV678; HHGV678; HH GV678; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(6-methyl-5-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}-3-pyridinyl)-3-(trifluoromethyl)benzamide. Grades: >98%. CAS No. 895519-90-1. Molecular formula: C29H29F3N8O. Mole weight: 562.59. | |
| Flumethasone pivalate | Flumethasone pivalate is a topical glucocorticoid receptor agonist with anti-inflammatory, antipruritic and vasoconstrictive properties. Uses: Anti-inflammatory drug. Synonyms: Locorten; Flumetasone pivalate; Lorinden; Locacorten; [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate. Grades: 99%. CAS No. 2002-29-1. Molecular formula: C27H36F2O6. Mole weight: 494.57. | |
| Flumizole | Flumizole is a non-steroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX). Uses: An antiinflammatory agent. Synonyms: Flumizole; UNII-Y4YQF944N9; CP-22665; Flumizolum; Flumizol; Flumizole (USAN/INN); AC1L1XWB; Flumizol [INN-Spanish]; CP 22665. CP-22,665; 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole. Grades: ≥98%. CAS No. 36740-73-5. Molecular formula: C18H15F3N2O2. Mole weight: 348.32. | |
| Flumorph | Flumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore germination and hyphal growth. In flumorph-treated hyphae, the most characteristic change was the development of periodic swelling ("beaded" morphology) and the disruption of tip growth. Upon removing flumorph, normal tip growth and organized F-actin were observed again. Flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen. Synonyms: Flumorph; SYP-L190; X-5977; SYP L190; X 5977; SYPL190; X5977. Grades: >98%. CAS No. 211867-47-9. Molecular formula: C21H22FNO4. Mole weight: 371.4. | |
| Flunarizine | Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity and duration of attacks of paralysis and is effective in rapid onset dystonia-parkinsonism. It is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy. It has been shown to significantly reduce headache frequency and severity in both adults and children. It was discovered at Janssen Pharmaceutica in 1968. It has been listed. Uses: Flunarizine is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. it is used as an adjuvant in the therapy of epilepsy. Synonyms: R-14950; R 14950; R14950; Sibelium; Flunarizinum; Flunarizina; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine; Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-. Grades: 95%. CAS No. 52468-60-7. Molecular formula: C26H26F2N2. Mole weight: 404.50. | |
| Fluocinolone acetonide | Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone. Uses: Glucocorticoids, synthetic; glucocorticoids, topical. Synonyms: Isepamicine (Isepamycin, sch21420) Sulphate. Grades: >98%. CAS No. 67-73-2. Molecular formula: C24H30F2O6. Mole weight: 452.488. | |
| Fluorobexarotene | Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors). Synonyms: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid. Grades: ≥97% by HPLC. CAS No. 1190848-23-7. Molecular formula: C24H27FO2. Mole weight: 366.47. | |
| fluoro-Dapagliflozin | fluoro-Dapagliflozin is an analog of dapagliflozin that demonstrates similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively). Synonyms: flouro-DAPA; (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4-deoxy-4-fluoro-D-glucitol. Grades: ≥95%. CAS No. 1181681-43-5. Molecular formula: C21H24ClFO5. Mole weight: 410.9. | |
| Flupenthixol dihydrochloride | Flupenthixol dihydrochloride is a dopamine receptor antagonist used as an antipsychotic drug for schizophrenia treatment. Mixture of E/Z isomers (ratio: 60:40). Uses: Antipsychotic drug. Synonyms: (E/Z)-Flupentixol Dihydrochloride; Emergil; FX 703; FX703; FX-703; Metamin; Siplarol; 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride. Grades: ≥99% by HPLC. CAS No. 2413-38-9. Molecular formula: C23H25F3N2OS.2HCl. Mole weight: 507.44. | |
| Fluphenazine decanoate dihydrochloride | Fluphenazine is a potent antipsychotic that acts by inhibiting dopamine receptors (Ki values 0.2 nM, 0.11 nM, and 2.0nM for D2, D3, and 5-HT2 receptors, respectively). Fluphenazine exhibits considerable affinity for 5-HT6 and 5-HT7 receptors (Ki values 15.8nM and 7.9 nM, respectively) as well. Uses: Antipsychotic. Synonyms: 2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate dihydrochloride. Grades: 99%. CAS No. 2376-65-0. Molecular formula: C32H44F3N3O2S.2HCl. Mole weight: 664.69. | |
| Flupirtine | Flupirtine is a selective neuronal potassium channel opener act as an Analgesic, having substituted pyridine with central analgesic properties. Uses: An analgesic, having substituted pyridine with central analgesic properties. Synonyms: D 9998; D9998; D-9998;Katadolon;ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate. Grades: ≥95%. CAS No. 56995-20-1. Molecular formula: C15H17FN4O2. Mole weight: 304.32. | |
| Flupirtine Hydrochloride | Flupirtine is an agonist of Kv7 potassium (KCNQ) channels, doubles channel currents when applied at 10 μM. Uses: Non-opioid analgesic with muscle relaxant properties. Synonyms: ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate;hydrochloride. Grades: ≥98%. CAS No. 33400-45-2. Molecular formula: C15H18ClFN4O2. Mole weight: 340.78. | |
| Fluprostenol methyl ester | Fluprostenol is an F-series prostaglandin analog which demonstrates as a luteolytic in veterinary animals. Synonyms: 7-[(1R,2R,3R5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-(5Z)-heptenoic acid, methyl ester. Grades: ≥98%. CAS No. 73275-76-0. Molecular formula: C24H31F3O6. Mole weight: 472.5. | |
| Fluspirilene | Fluspirilene, with antipsychotic activity, is a non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 μM). Fluspirilene is also a dopamine inhibitor. Synonyms: R6218; R-6218; R 6218; FLUSPIRILENE;8-(4,4-BIS[P-FLUOROPHENYL]BUTYL)-1-PHENYL-1,3,8-TRIAZINO(4,5)DECAN-4-ONE;R 6218;1-phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane;8-(4,4-bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one;8-triaza. Grades: >98%. CAS No. 1841-19-6. Molecular formula: C29H31F2N3O. Mole weight: 475.57. | |
| Fluvastatin | Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR) with IC50 of 8 nM. It belongs to a class of the statin drug and is structurally distinct from the fungal derivatives of this therapeutic class. It binds of the substrate HMG-CoA with Ki value of 0.3 nM but not with respect to binding of NADPH. It is marketed under the trade name Lescol® and is used to treat hypercholesterolemia and to prevent cardiovascular disease. It induces G2/M phase arrest and has antilipemic effect. Uses: Fluvastatin is used to treat hypercholesterolemia and to prevent cardiovascular disease. it has antilipemic effect. Synonyms: XU-62320; XU 62320; XU62320; Cranoc;Lescol;(+)-(3R,5S)-fluvastati;(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid;6-Heptenoic acid,7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-,[R*,S*-(E)]-. Grades: 99%. CAS No. 93957-54-1. Molecular formula: C24H26FNO4. Mole weight: 411.47. | |
| Fobrepodacin | Fobrepodacin is an orally active and potent phosphate prodrug of SPR719 and has potent bactericidal activities in vivo. Synonyms: 2-(5-{2-[(ethylcarbamoyl)amino]-6-fluoro-7-[(2R)-oxolan-2-yl]-1H-benzimidazol-5-yl}pyrimidin-2-yl)propan-2-yl dihydrogen phosphate; N-Ethyl-N'-(6-fluoro-5-(2-(1-methyl-1-(phosphonooxy)ethyl)-5-pyrimidinyl)-7-((2R)-tetrahydro-2-furanyl)-1H-benzimidazol-2-yl)urea; SPR720; SPR-720; SPR 720; pVXc-486; pVXc 486; pVXc486; (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate. Grades: ≥98%. CAS No. 1384984-31-9. Molecular formula: C21H26FN6O6P. Mole weight: 508.44. | |
| Folinic acid | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is a 5-formyl derivative of tetrahydrofolic acid and readily converted to other reduced folic acid derivatives, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. Synonyms: leucovorin. Grades: >98%. CAS No. 58-05-9. Molecular formula: C20H23N7O7. Mole weight: 473.44. | |
| Fonazine | Dimetotiazine is a histamine H1 receptor antagonist. It is a phenothiazine drug used for the treatment of migraine. Uses: Migraine. Synonyms: Fonazine; Dimetotiazine; Dimethothiazine; Dimetiotazine; Banistyl; Dimethodin; fonazine mesylate; fonazine monomesylate ;Migristene; Promaquid;10-(2-(Dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide;7455-39-2(Dimetotiazine Mesilate). Grades: 98%. CAS No. 7456-24-8. Molecular formula: C19H25N3O2S2. Mole weight: 391.55. | |
| Forasartan | Forasartan, a tetrazol derivative, has been found to be a angiotensin II receptor antagonist that could be effective against hypertension through influencing the vasoconstriction and the formation of aldosterone. Uses: Forasartan has been found to be a angiotensin ii receptor antagonist that could be effective against hypertension through influencing the vasoconstriction and the formation of aldosterone. Synonyms: Forasartan; SC-52458; SC 52458; SC52458. UNII-065F7WPT0B; CHEMBL315021; 5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine. Grades: 98%. CAS No. 145216-43-9. Molecular formula: C23H28N8. Mole weight: 416.52. | |
| Forodesine | Forodesine, also known as BCX-1777, is the hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction. Synonyms: Immucillin-H hydrochloride; Forodesine. Grades: 98%. CAS No. 209799-67-7. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
| Forodesine hydrochloride | Forodesine hydrochloride is the hydrochloride salt of Forodesine. Forodesine, also called as BCX-1777 or Immucillin-H, is an orally bioavailable inhibior of mammalian purine nucleoside phosphorylase (PNP). Forodesine is undergoing a phase II trial to trea. Synonyms: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitolBCX-1777; BCX1777BCX1777forodesineImmH cpdimmucillin Himmucillin-H. CAS No. 284490-13-7. Molecular formula: C11H15ClN4O4. Mole weight: 302.715. | |
| Fosamprenavir Calcium Salt | HIV protease inhibitor; water soluble prodrug of amprenavir. Synonyms: GW 433908G; Lexiva; GW433908G; GW-433908G. Grades: >98%. CAS No. 226700-81-8. Molecular formula: C25H34CaN3O9PS. Mole weight: 623.67. | |
| Fostamatinib | Fostamatinib, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibiting Syk but not Lyn, and 5-fold less potent to Flt3. Synonyms: R788; R 788; R-788. Grades: >98%. CAS No. 901119-35-5. Molecular formula: C23H26FN6O9P. Mole weight: 580.46. | |
| Fostamatinib sodium | R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. Synonyms: R935788. Code names: R788 sodium. R935788 sodium. CAS No. 1025687-58-4. Molecular formula: C23H24FN6O9P.2Na. Mole weight: 624.42. | |
| FPA 124 | FPA 124 is an Akt/PKB inhibitor (IC50 = 100 nM) that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Synonyms: FPA 124; FPA124; FPA-124; Akt Inhibitor XI; Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex. CAS No. 902779-59-3. Molecular formula: C11H9Cl2CuN3O2S. Mole weight: 381.73. | |
| FPL 55712 | FPL 55712 is a leukotriene receptor antagonist that inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4. Synonyms: FPL 55712; FPL55712; FPL-55712; 7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid. Grades: ≥97% by HPLC. CAS No. 40785-97-5. Molecular formula: C27H30O9. Mole weight: 498.52. | |
| FPL 64176 | FPL 64176 is a potent L-type Ca2+ channel activator (EC50 = 16 nM) displaying 40-fold potency against Bay K 8644 as a positive inotrope in guinea pig atria. Uses: Calcium channel agonists. Synonyms: FPL-64176; FPL 64176; FPL64176; 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester; Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate. Grades: ≥99% by HPLC. CAS No. 120934-96-5. Molecular formula: C22H21NO3. Mole weight: 347.41. | |
| FPS-ZM1 | FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. It binds exclusively to RAGE and inhibits β-secretase activity and Aβ production. It also suppresses microglia activation and the neuroinflammatory response in brain. It penetrates the blood-brain barrier and binds to RAGE, thus reducing the protein levels of various cytokines. It inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. It is not toxic to mice and can easily cross the blood-brain barrier in vivo. It might be a novel therapeutic agent to treat AD patients. Uses: Fps-zm1 might be a novel therapeutic agent to treat ad patients. Synonyms: FPS-ZM1; FPS ZM1; FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1; N-benzyl-4-chloro-N-cyclohexylbenzaMide;4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide. Grades: >98 %. CAS No. 945714-67-0. Molecular formula: C20H22ClNO. Mole weight: 327.85. | |
| FR 110302 | This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma in Japan. Synonyms: FR 110302; FR110302; FR-110302. 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-1-Naphthalenol. Grades: 98%. CAS No. 119256-94-9. Molecular formula: C28H35NO2. Mole weight: 417.58. | |
| FR 122047 hydrochloride | FR-122047 is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 values is 0.028μM for COX-1 and 65 μM for COX-2. FR-122047 displays 2300 fold greater selectivity towards inhibition of COX-1 over COX-2. It shows analgesic, anti-platelet and anti-inflammatory properties. No development was reported for the treatment of Pain, Rheumatoid arthritis and Thrombosis. Uses: Pain; rheumatoid arthritis; thrombosis. Synonyms: FR 122047 hydrochloride;1-[[4,5-bis-(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride. Grades: >98 %. CAS No. 130717-51-0. Molecular formula: C23H25N3O3S.HCl. Mole weight: 459.99. | |
| FR122047 hydrochloride hydrate | FR122047 is a selective inhibitor of COX-1 with an IC50 value of 0.028 μM. Synonyms: 1-[[4,5-bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine, monohydrochloride, monohydrate. Grades: ≥98%. Molecular formula: C23H25N3O3S·HCl·H2O. Mole weight: 478. | |
| FR 139317 | FR 139317 is a selective Endothelin A receptor antagonist originated by Fujisawa. (Ki values are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). No development was reported for the treatment of Cerebrovascular disorders, Coronary disorders, Diabetic nephropathies, Heart failure, Hypertension, Ischaemic heart disorders, Myocardial infarction and Renal failure. Uses: Cerebrovascular disorders; coronary disorders; diabetic nephropathies; heart failure; hypertension; ischaemic heart disorders; myocardial infarction; renal failure. Synonyms: FR 139317; FR139317; FR139317; PD 147953; PD147953; PD-147953; 2-((1-(Hexahydro-1H-azepinyl)carbonyl)amino-4-methylpentanoyl)-3-(-(1-methyl-1H-indolyl)propionyl)amino-3-(2-pyridyl)propionic acid. Grades: 98 %. CAS No. 142375-60-8. Molecular formula: C33H44N6O5. Mole weight: 604.75. | |
| FR-167653 Free base | FR-167653, a pyrazolo?triazin derivative, has been found to be a cytokine inhibitor as well as P38 mitogen-activated protein kinase inhibitor and was once studied as an anticoagulant. Synonyms: FR167653; FR-167653; FR 167653; 1,?2-Ethanedione, 1-[7-(4-fluorophenyl)?-3,?4-dihydro-8-(4-pyridinyl)?pyrazolo[5,?1-c]?[1,?2,?4]?triazin-2(1H)?-yl]?-2-phenyl-. Grades: 98%. CAS No. 158876-65-4. Molecular formula: C24H18FN5O2. Mole weight: 427.43. | |
| FR 171113 | FR 171113 is a protease-activated receptor 1 (PAR1) antagonist displaying significant antiplatelet activity in vitro. It inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time. Synonyms: FR 171113; FR171113; FR-171113; 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester. Grades: ≥98% by HPLC. CAS No. 173904-50-2. Molecular formula: C19H11Cl3N2O4S. Mole weight: 469.73. | |
| FR180204 | FR180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.FR180204 showed activity to inhibit ERKs (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Synonyms: FR180204; FR-180204; FR 180204. Grades: 0.98. CAS No. 865362-74-9. Molecular formula: C18H13N7. Mole weight: 327.351. | |
| FR-181157 Free base | FR-181157 is an orally active prostacyclin mimetic that shows high potency and agonist efficacy at the IP receptor. Synonyms: sodium;2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate; FR 181157; FR181157; 200433-03-0 (FR-181157 Free Base). Grades: >98%. CAS No. 200433-03-0. Molecular formula: C30H26NNaO4. Mole weight: 487.52. | |
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