BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Enalapril | Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies. Its IC50 values range from 2 to 800 nM. lt belongs to a class of medications called angiotensin converting enzyme inhibitors. pressure. lt decreases levels of angiotensin II leading to less vasoconstriction and decreased blood pressure by inhibiting ACE. lt has been shown to lower the death rate in systolic heart failure. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Uses: Enalapril is used in the treatment of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies. lt decreases levels of angiotensin ii leading to less vasoconstriction and decreased blood pressure by inhibiting ace. lt lowers the death rate in systolic heart failure. Synonyms: (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid. Grades: 98 %. CAS No. 75847-73-3. Molecular formula: C20H28N2O5. Mole weight: 376.45. |  |
| Enalkiren | Enalkiren: Introducing Enalkiren is an efficacious and exclusive suppressor of human renin, a pivotal enzyme within the renin-angiotensin-aldosterone system. Its indispensable role lies in studying hypertension (increased blood pressure) and congestive heart failure. Uses: Protease inhibitors. Synonyms: Enalquireno; Enalkirene; 3-amino-N-[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-methylbutanamide. CAS No. 113082-98-7. Molecular formula: C35H56N6O6. Mole weight: 656.86. | |
| Enasidenib mesylate | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes indicated for the treatment of adult patients with replased or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. Synonyms: methanesulfonic acid;2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol; Enasidenib (mesylate); AG-221 mesylate; Enasidenib mesilate; Enasidenib methanesulfonate; Enasidenib mesylate [USAN]. CAS No. 1650550-25-6. Molecular formula: C20H21F6N7O4S. Mole weight: 569.48. | |
| Enazadrem phosphate | Enazadrem phosphate is a 5-lipoxygenase inhibitor as an Antipsoriatic agent. Uses: Antipsoriatic agent. Synonyms: UNII-93VML10KA9; ENAZADREM PHOSPHATE; Enazadrem phosphate (USAN); Enazadrem phosphate [USAN]; SCHEMBL219332; 93VML10KA9; D03990;4,6-Dimethyl-2-((6-phenylhexyl)amino)-5-pyrimidinol phosphate (1:1) (salt);107361-33-1(base). Grades: 98%. CAS No. 132956-22-0. Molecular formula: C18H28N3O5P. Mole weight: 397.41. | |
| Encainide Hydrochloride | Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated sodium channels and slows conduction within the His-Purkinje system and myocardium. It has antifibrillatory activity. It was developed by Bristol-Myers Squibb and is no longer used because of its frequent proarrhythmic side effects. Uses: Encainide hydrochloride is a sodium channel blocker and class ic antiarrhythmic agent. Synonyms: Encainide HCl;MJ9067 hydrochloride;MJ-9067 hydrochloride;4-Methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide hydrochloride;4-Methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide hydrochloride. Grades: 98%. CAS No. 66794-74-9. Molecular formula: C22H29ClN2O2. Mole weight: 388.94. | |
| Encaleret | Encaleret is a calcium-sensing receptor (CaSR) antagonist. But in Oct 2011, Phase-II for Osteoporosis in USA was discontinued. Uses: Osteoporosis. Synonyms: 1214922-52-7 (sulfate salt);JIT-305; JIT 305; JIT305; 2'-((R)-1-((R)-3-((1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)ethyl)-3-methyl-[1,1'-biphenyl]-4-carboxylic acid. Grades: 98%. CAS No. 787583-71-5. Molecular formula: C29H33ClFNO4. Mole weight: 514.03. | |
| ENCALERET SULFATE | This active molecular is an CaSR (calcium-sensing receptor antagonist) under the developmet of Tobacco and Merck & Co. Calcium-sensing receptor is a member of the G protein-coupled receptor and it is very important to modulate Ca2+ homeostasis via its role in the parathyroid glands and kidneys. Encaleret was used for the treatment of osteoporosis., but was discontinued in Phase-II in Japan, India and USA in 2011. Uses: The treatment of osteoporosis. Synonyms: 4-[2-[(1R)-1-[(2R)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid;sulfuric acid;hydrate; JIT305; JIT 305; JIT-305. Grades: 98%. CAS No. 1214922-52-7. Molecular formula: C58H70Cl2F2N2O13S. Mole weight: 1144.16. | |
| Encenicline, HCl salt | EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor. In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drugs. Synonyms: EVP-6124; EVP 6124; EVP6124; MT-4666; MT 4666; MT4666; Encenicline. IUPAC/Chemical name:(R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride. Grades: 0.98. CAS No. 550999-74-1. Molecular formula: C16H18Cl2N2OS. Mole weight: 357.293. | |
| Endomorphin 1 trifluoroacetate salt | Endomorphin 1, an endogenous neuropeptide, is found in the brain and, to a lesser extent, in the spinal cord. It is an agonist of μ-opioid receptor (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties, which is selective for μ- over δ- and κ-opioid receptors (Ki = 1,506 and 5,428 nM, respectively). Synonyms: L-tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C34H38N6O5·xCF3COOH. Mole weight: 610.70. | |
| Endomorphin 2 trifluoroacetate salt | Endomorphin 2, an endogenous neuropeptide, is found in the spinal cord and, to a lesser extent, in the brain. It is an agonist of μ-opioid receptor (Ki = 0.69 nM) that has analgesic, negative reinforcing, and gastrointestinal properties, which is selective for μ- over δ- and κ-opioid receptors (Kis = 9,233 and 5,240 nM, respectively). Synonyms: L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C32H37N5O5·xCF3COOH. Mole weight: 571.67. | |
| Endothelin-1 (human, porcine) trifluoroacetate salt | Endothelin-1 is a peptide vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells. It is an agonist of endothelin (ET) receptors ETA and ETB (IC50s = 0.15 and 0.12 nM, respectively). Synonyms: ET-1. Grades: ≥95%. Molecular formula: C109H159N25O32S5·xCF3COOH. Mole weight: 2491.91. | |
| Endothelin-2 (human) trifluoroacetate salt | Endothelin-2 is a secretory peptide vasoconstrictor and ligand for the endothelin (ET) receptors ETA and ETB (Kbs= 32.8 and 1.33 nM, respectively). It displays similar selectivity for ETA and ETB endothelin receptors. Synonyms: ET-2. Grades: ≥95%. Molecular formula: C115H160N26O32S4·xCF3COOH. Mole weight: 2546.92. | |
| Endoxifen E-isomer hydrochloride | The hydrochloride salt form of E-isomer of Endoxifen which is a significant metamolite of Tamoxifen, could be a regulator of estrogen receptor and could be effective in the treatment of estrogen-dependent breast cancer. Uses: The hydrochloride salt form of e-isomer of endoxifen which could be a regulator of estrogen receptor and could be effective in the treatment of estrogen-dependent breast cancer. Synonyms: E-Endoxifen hydrochloride. Grades: 98%. CAS No. 1197194-61-8. Molecular formula: C25H28ClNO2. Mole weight: 409.95. | |
| Endoxifen HCl | Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2. Endoxifen shows anti-estrogenic effects, and decreases the E2-induced PR expression in MCF-7 cells. In vivo, Endoxifen (8 mg/kg, ) inhibits growth of MCF-7 human mammary tumor xenografts in mice. Synonyms: Z-Endoxifen HCl; Z Endoxifen HCl; ZEndoxifen HCl; Z Endoxifen Hydrochloride; ZEndoxifen Hydrochloride. Grades: 98%. CAS No. 1032008-74-4. Molecular formula: C25H28ClNO2. Mole weight: 409.95. | |
| Endoxifen hydrochloride | Endoxifen hydrochloride is a metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM) that inhibits the growth of estrogen-stimulated BT474 cells (IC50 = 54 nM). Endoxifen is used for the treatment of estrogen receptor (ER) positive breast cancer. Uses: Anticancer drug. Synonyms: 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-Phenol hydrochloride (1:1). Grades: 99%. CAS No. 1197194-41-4. Molecular formula: C25H28ClNO2. Mole weight: 409.95. | |
| ENMD-2076 L-(+)-Tartaric acid | ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2. Synonyms: ENMD-2076 L-(+)-Tartaric acid; ENMD 2076 L-(+)-Tartaric acid; ENMD2076 L-(+)-Tartaric acid. Grades: >98%. CAS No. 1291074-87-7. Molecular formula: C25H31N7O6. Mole weight: 525.56. | |
| Enoxacin hydrate | Enoxacin hydrate is a synthetic antibiotic belonging to quinolone carboxylic acid compound. It is bactericidal and has a postantibiotischen effect. It is a broad-spectrum antibacterial agent and inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. Uses: Enoxacin hydrate is bactericidal and has a postantibiotischen effect. it is a broad-spectrum antibacterial agent. Synonyms: Enoxacin sesquihydrate;AT-2266 hydrate;CI-919 hydrate; AT 2266 hydrate;CI 919 hydrate; AT2266 hydrate;CI919 hydrate; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid hydrate. Grades: >98%. CAS No. 84294-96-2. Molecular formula: C30H40F2N8O9. Mole weight: 694.694. | |
| Enoximone | Enoximone is a selective phosphodiesterase III (PDE3) inhibitor. It can be used for the treatment of heart failure. Uses: Heart failure. Synonyms: Enoximone; Perfan; Fenoximone; MDL-17043; Enoximonum [Latin]; MDL 19438; MDL-17,043; MDL-17043; MDL-19,438; MDL17,043; MDL17043; MDL19,438; Myogen Brand of Enoximone; Perfan; 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one; Fenoximone; MDL 17043; Perfan; Perfane; RMI 17043. Grades: 98%. CAS No. 77671-31-9. Molecular formula: C12H12N2O2S. Mole weight: 248.3. | |
| Enrasentan | Enrasentan, an indene derivative, has been found to be an endothelin receptor antagonist that was once studied in reperfusion injury and heart failure therapy. Synonyms: Enrasentan; SB-217242; UNII-QG16H8A6ZH; SB 217242; SB217242; CHEMBL431651; (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid. Grades: 98%. CAS No. 167256-08-8. Molecular formula: C29H30O8. Mole weight: 506.55. | |
| Entacapone sodium salt | Entacapone is a specific, potent catechol-O-methyl transferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. Synonyms: Entacapone sodium salt; 1047659-02-8; Entacapone (sodium salt); Entacapone Sodiumsodium; 4-[(E)-2-cyano-3-(diethylamino)-3-oxoprop-1-enyl]-2-hydroxy-6-nitrophenolate. Grades: >98%. CAS No. 1047659-02-8. Molecular formula: C14H14N3NaO5. Mole weight: 327.27. | |
| EO 1428 | EO 1428 is a selective inhibitor of p38α and p38β2 MAP kinase, but displays no activity at p38γ, p38δ, ERK1/2 and JNK1. EO 1428 inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 - 4, 5, 17, 30 and 74 nM, respectively) and acts against inflammation in murine models of acute and chronic dermatitis. Synonyms: EO-1428; EO 1428; EO1428; (2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone. Grades: ≥98% by HPLC. CAS No. 321351-00-2. Molecular formula: C20H16BrClN2O. Mole weight: 415.71. | |
| EP-024297 | EP-024297 is a novel agonist of farnesoid X receptor (FXR). Study in Chinese hamster ovary cells showed that it is 20000-fold more potent than obeticholic acid (OCA). EP-024297 is selective for FXR over TGR5. It promisingly becomes a new treatment of NASH. Uses: The potential treatment of nash. Synonyms: EP-024297; EP 024297; EP024297. | |
| EP1013 | EP1013 is a broad-spectrum caspase selective inhibitor with no observed toxicity in rodents, used in the research of type 1 diabetes. Synonyms: EP 1013; EP-1013; (3S) -5-fluoro-3-[[ (2S) -3-methyl-2- (phenylmethoxycarbonylamino) butanoyl]amino]-4-oxopentanoic acid; benzyloxycarbonyl-valyl-aspartic acid fluoromethyl ketone; EP1013; F573 compound; MX1013; N-benzyloxycabonyl-Val Asp-fluoromethyl ketone; Z-VD-FMK; zVD-FMK. CAS No. 223568-55-6. Molecular formula: C18H23FN2O6. Mole weight: 382.38. | |
| EP1-antanoist-1 | A EP1 antagonist (pKi= 7.54) (pIC50= 8.5). Synonyms: 1-[[5-Bromo-2-[[ (2, 4-dichlorophenyl) methyl]oxy]phenyl]methyl]-5-methyl-1H-pyrazole-3-carboxylic acid. CAS No. 851204-35-8. Molecular formula: C19H15BrCl2N2O3. Mole weight: 470.14. | |
| EP6 | EP6 is a 5-lipoxygenase (5-LO) inhibitor. Synonyms: EP-6; EP 6. Grades: ≥98% by HPLC. CAS No. 1353567-32-4. Molecular formula: 24H30N4O. Mole weight: 390.5. | |
| Eperezolid | Eperezolid(PNU-100592) is a oxazolidinone antibacterial agent, Eperezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml). Synonyms: PNU-100592; PNU100592; PNU 100592. Grades: >98%. CAS No. 165800-04-4. Molecular formula: C18H23FN4O5. Mole weight: 394.4. | |
| Epertinib | Epertinib, also known as S-222611, is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively, currently under trials in patients with solid tumours. It also inhibited intracellular kinase activity and the growth of EGFR-expressing and HER2-expressing cancer cells. Synonyms: Epertinib; S-22611; S22611; S 22611; (R, Z) -1- (4- ( (3-chloro-4- ( (3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) but-2-yn-1-one O-morpholin-3-ylmethyl oxime; Epertinib; S-222611; S222611; S 222611; 2-Butyn-1-one, 1-(4-((3-chloro-4-((3-fluorophenyl)methoxy)phenyl)amino)-6-quinazolinyl)-, O-((3R)-3-morpholinylmethyl)oxime, (1Z)-; N-{3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl}- 6-[(1Z)-N-{[(3R)-morpholin-3-yl]methoxy}but- 2-ynimidoyl]quinazolin-4-amine. CAS No. 908305-13-5. Molecular formula: C30H27ClFN5O3. Mole weight: 559.178. | |
| EPI-001 | EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ?6 μM and a selective PPAR-gamma modulator. Synonyms: EPI001; EPI 001. Grades: 98%. CAS No. 227947-06-0. Molecular formula: C21H27ClO5. Mole weight: 394.89. | |
| Epiallopregnanolone | Epiallopregnanolone, a metabolite of progesterone, is a novel derivative of the steroid Dehydroepiandrosterone (DHEA). Epiallopregnanolone is a 3β-isomer of allopregnanolone. Epiallopregnanolone is inactive as a GABAA receptor modulator and is used as a control substance to examine GABA neurotransmission. Synonyms: 5α-Pregnan-20-one; 3β,21-dihydroxy-5α-Pregnan-20-one; 3β,5α-Tetrahydrodeoxycorticosterone; 3β,5α-Tetrahydroprogesterone; 2-hydroxy-1-[(3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone. Grades: ≥95%. CAS No. 567-01-1. Molecular formula: C21H34O3. Mole weight: 334.5. | |
| Epiberberine | The anti-adipogenic effect of Epiberberine is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. Uses: Anti-adipogenic. Synonyms: epiberberine; 11,12-Dihydro-8,9-dimethoxybenzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium; Epiberberine Chloride; BerbiniuM. Grades: >98%. CAS No. 6873-9-2. Molecular formula: C20H18NO4. Mole weight: 336.36. | |
| Epidermal Growth Factor | Epidermal Growth Factor (EGF) is a protein that stimulates the proliferation of different types of cells via binding to its receptor EGFR. EGF has been found in many human tissues such as submandibular gland and parotid gland. Synonyms: EGF. Molecular formula: C257H381N73O83S7. Mole weight: 6046. | |
| Epinastine | Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for the H1 receptor and does not cross the blood-brain-barrier. It shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. It inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. It is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. It antagonises octopamine-induced cAMP formation in the insect brain. It is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance. It is produced by Allergan and marketed by Inspire in the United States. Uses: Epinastine is used in eye drops to treat allergic conjunctivitis. it is highly selective for the h1 receptor and does not cross the blood-brain-barrier. Synonyms: 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine;3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine;Apinastine Base;WAL 801. Grades: >98%. CAS No. 80012-43-7. Molecular formula: C16H15N3. Mole weight: 249.31. | |
| Eplivanserin hemifumarate | Eplivanserin hemifumarate is a potent and selective 5-HT2A antagonist (IC50 = 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively) with no activity for dopamine, histamine and adrenergic receptors. It attenuates cocaine-induced hyperactivity, increases dopamine (DA) release in rat medial prefrontal cortex (mPFC) and potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens. Synonyms: SR-46349B; SR 46349B; SR46349B; (1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate. Grades: ≥98% by HPLC. CAS No. 130580-02-8. Molecular formula: C19H21FN2O2.1/2C4H4O4. Mole weight: 386.42. | |
| EPPTB | EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist that inihbits the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. EPPTB enhances DA potency at the D2 receptor. Synonyms: Ro 5212773; Ro5212773; Ro-5212773; N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide. Grades: ≥99% by HPLC. CAS No. 1110781-88-8. Molecular formula: C20H21F3N2O2. Mole weight: 378.39. | |
| Eprobemide | Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor and can be used as an antidepressant. Synonyms: LIS 630. Grades: 98%. CAS No. 87940-60-1. Molecular formula: C14H19ClN2O2. Mole weight: 282.769. | |
| Eptapirone | Eptapirone, a triazine derivative, has been found to be a 5-HT1A receptor agonist and was once studied as an antidepressant agent. pKi: 8.33. Synonyms: F11440; F-11440; F 11440; Eptapirone; L0068; L-0068; L 0068; Eptapirone; Eptapirone [INN]; F 11440; 4-methyl-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,4-triazine-3,5-dione. Grades: 98%. CAS No. 179756-85-5. Molecular formula: C16H23N7O2.C4H4O4. Mole weight: 461.47. | |
| EPZ004777 hydrochloride | EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells. EPZ004777 selectively inhibits proliferation of MLL-AF10 and CALM-AF10-transformed murine bone marrow cells. DOT1L inhibition by EPZ004777 results in significantly decreased proliferation, decreased expression of MLL-AF6 target genes, and cell cycle arrest of MLL-AF6-transformed cells. Synonyms: EPZ 004777 hydrochloride; EPZ-004777 hydrochloride; EPZ004777 hydrochloride. Grades: >98%. CAS No. 1380316-03-9. Molecular formula: C28H42ClN7O4. Mole weight: 576.13. | |
| EPZ005687 | EPZ005687 is a selective EZH2 enzyme inhibitor with Ki of 24 nM. It is 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. EPZ005687 can block trimethylation of the PRC2 target histone 3 lysine 27 with IC50 value of 80 nM, decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2. No development of preclinical research for the treatment of Cancer, Lymphoma and Solid tumours was reported. Uses: Cancer; lymphoma; solid tumours. Synonyms: EPZ005687; EPZ 005687; EPZ-005687; 1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide; 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide. Grades: 98%. CAS No. 1396772-26-1. Molecular formula: C32H37N5O3. Mole weight: 539.67. | |
| EPZ011989 trifluoroacetate | EPZ011989 trifluoroacetate is the trifluoroacetate salt form of EPZ011989. EPZ011989 is a potent and orally bioavailable inhibitor that specifically targets the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2), with significant tumor growth in. Synonyms: EPZ011989 TFA salt; EPZ011989 TFA; EPZ 011989 TFA; EPZ-011989 TFA; N-[ (4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl (methyl)amino]cyclohexyl]amino]-2-methyl-5- (3-morpholin-4-ylprop-1-ynyl)benzamide; 2, 2, 2-trifluoroacetic acidEPZ011989 (trifluoroacetate). CAS No. 1598383-41-5. Molecular formula: C37H52F3N5O6. Mole weight: 719.83. | |
| (±)-Equol | (R,S)-Equol is a flavonoid. Racemic mixture. This is a metabolite that is produced in vivo from soy phytoestrogen daidzein from gut microflora. (R,S)-Equol inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. (R,S)-Equol shows positive effects on the incidence of prostate cancer. Functions as a DHT blocker. Preferentially activates estrogen receptor β (ERβ). Uses: Phytoestrogens. Synonyms: 3-(4-hydroxyphenyl)chroman-7-ol. Grades: ≥98%. CAS No. 94105-90-5. Molecular formula: C15H14O3. Mole weight: 242.3. | |
| ER 27319 maleate | ER 27319 maleate is a selective Syk kinase inhibitor. It suppresses tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells, causing the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events. Synonyms: ER27319 maleate; ER-27319 maleate; 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate; 9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1); 3,4-Dimethyl-10-(3-aminopropyl)-9-acridone maleate. Grades: ≥99% by HPLC. CAS No. 1204480-26-1. Molecular formula: C18H20N2O.C4H4O4. Mole weight: 396.17. | |
| ER 50891 | ER 50891 is an RARα receptor antagonist (IC50 = 31.2 nM). Synonyms: ER 50891; ER50891; ER-50891; 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid. Grades: ≥99% by HPLC. CAS No. 187400-85-7. Molecular formula: C29H24N2O2. Mole weight: 432.51. | |
| ER 819762 | ER 819762 is a potent and selective EP4 receptor antagonist (IC50 = 59 nM) that inhibits EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. It was shown to suppress Th1 and Th17 cytokine production, collagen- and GPI-induced arthritis in mice. It attenuates CFA-induced inflammatory pain in rats. Uses: Analgesic. Synonyms: ER819762; ER 819762; ER-819762. (10S)-1'-[(3,5-Dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methylspiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one. Grades: ≥98% by HPLC. CAS No. 1155773-15-1. Molecular formula: C30H39N3O3. Mole weight: 489.65. | |
| ERA63 | A selective agonist of estrogen receptor &alpha. Synonyms: ERA63; ERA 63; ERA-63; (7R,8R,9S,13S,14S,17R)-17-ethynyl-7,13-dimethyl-3-methylidene-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol. CAS No. 343248-86-2. Molecular formula: C22H30O. Mole weight: 310.47. | |
| Eravacycline dihydrochloride | Eravacycline, a novel fluorocycline previously known as TP-434, in virto has broad-spectrum activity against both Gram-positive and Gram-negative aerobic and anaerobic pathogens including important antimicrobial resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and extended-spectrum ?-lactamase (ESBL)-producing and carbapenemaseproducing Enterobacteriaceae and multidrug-resistant Acinetobacter baumannii. Synonyms: (4S,4aS,5aR,12aR)-4-(dimethylamino)-7-fluoro-1,10,11,12a-tetrahydroxy-3,12-dioxo-9-[(2-pyrrolidin-1-ylacetyl)amino]-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;dihydrochloride; Eravacycline (dihydrochloride). CAS No. 1334714-66-7. Molecular formula: C27H33Cl2FN4O8. Mole weight: 631.48. | |
| ERB-041 | ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Er&alpha. Uses: Potent erβ agonist. Synonyms: Prinaberel;2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol; ERB041; ERB 041; ERB041; Prinaberel; WAY-202041; WAY202041; WAY 202041 (4Z)-4-(7-ethenyl-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)-2-fluorocyclohexa-2,5-dien-1-one. Grades: ≥98%. CAS No. 524684-52-4. Molecular formula: C15H10FNO3. Mole weight: 271.24. | |
| Eribaxaban | Eribaxaban is an orally active inhibitor of coagulation factor Xa (activated factor X). It has anticoagulant activity and is used as an anticoagulant drug. It is used for the treatment and prevention of thrombotic disorders. It inhibited arterial thrombosis comparable to aspirin plus clopidogrel. It was developed by Pfizer. It was in phase II clinical trials, but has been terminated. Uses: Eribaxaban has anticoagulant activity and is used as an anticoagulant drug. it is used for the treatment and prevention of thrombotic disorders. Synonyms: PD348292; PD-348292; PD 348292; PD0348292; PD-0348292; PD 0348292; PD348,292; PD-348,292; PD 348,292; Eribaxaban;(2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide. Grades: 98%. CAS No. 536748-46-6. Molecular formula: C24H22ClFN4O4. Mole weight: 484.91. | |
| Eritoran | Eritoran is a TLR4 antagonist that is developed for the treatment of severe sepsis. Grades: 95%. CAS No. 185955-34-4. Molecular formula: C66H126N2O19P2. Mole weight: 1313.7. | |
| ERK5-IN-2 | ERK5-IN-2 is a submicromolar selective ERK5 inhibitor with oral activity, which can inhibit tumor xenograft growth and basic fibroblast growth factor (bFGF)-driven Matrigel plug angiogenesis. Synonyms: 4-(2-Bromanyl-6-Fluoranyl-Phenyl)Carbonyl-{N}-Pyridin-3-Yl-1{H}-Pyrrole-2-Carboxamide; SCHEMBL17607180; BCP32587; EX-A4938. Grades: 98%. CAS No. 1888305-96-1. Molecular formula: C17H11BrFN3O2. Mole weight: 388.2. | |
| ERK Inhibitor | ERK inhibitor, a reversible thiazolidinedione compound, is a cell-permeable inhibitor that binds ERK2 near its docking domain with a KD of 5 μM and prevents its interaction with protein substrates. Synonyms: Extracellular Regulated Kinase Inhibitor; 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione, monohydrochloride. Grades: ≥95%. CAS No. 1049738-54-6. Molecular formula: C14H16N2O3S·HCl. Mole weight: 328.8. | |
| Erlotinib mesylate | Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. Synonyms: Tarceva; CP-358774; CP 358774; CP358774; OSI-774; OSI 774; OSI774; NSC 718781; NSC718781; NSC-718781; R 1415; R1415; R-1415. Grades: >98%. CAS No. 248594-19-6. Molecular formula: C23H27N3O7S. Mole weight: 489.54. | |
| (E)-(S)-4-[(S)-4-Methyl-2-((S)-3-methyl-2{(S)-2-[(5-methyl-isoxazole-3- carbonyl) -amino] -propionylamino}-butyrylamino) -pentanoylamino] -5- ( (S) -2- oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester | A SARS-CoV Mpro inhibitor. Synonyms: ethyl (E, 4S) -4- [ [ (2S) -4-methyl-2- [ [ (2S) -3-methyl-2- [ [ (2S) -2- [ (5-methylisoxazole-3-carbonyl) amino] propanoyl] amino] butanoyl] amino] pentanoyl] amino] -5- [ (3S) -2-oxopyrrolidin-3-yl] pent-2-enoate. Molecular formula: C30H46N6O8. Mole weight: 618.7. | |
| Esaxerenone | Esaxerenone is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist. Esaxerenone is currently under clinical trials developed by Daiichi Sankyo Company for the treatment of hypertension, essential hypertension, hyperaldosteronism, and diabetic nephropathies. Uses: Potential treatment of hypertension, diabetic nephropathies, etc. Synonyms: Esaxerenone; CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550; 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide. CAS No. 1632006-28-0. Molecular formula: C22H21F3N2O4S. Mole weight: 466.475. | |
| Espatropate | Espatropate is a Muscarinic receptor antagonist originated by Pfizer. It is a bronchodilator with antimuscarinic activity. No development was reported for the treatment of Asthma. Uses: Asthma. Synonyms: UK-88060; UNII-13MIU3750H; UK 88060; UNII 13MIU3750H; UK88060; UNII13MIU3750H; (R)-3-Quinuclidinyl (R)-alpha-(hydroxymethyl)-alpha-phenylimidazole-1-acetate. Grades: 98%. CAS No. 132829-83-5. Molecular formula: C19H23N3O3. Mole weight: 341.41. | |
| Estetrol | Estetrol is a human steroid hormone produced by fetal liver from estradiol and estriol during pregnancy. Synonyms: (8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol. CAS No. 15183-37-6. Molecular formula: C18H24O4. Mole weight: 304.386. | |
| Estradiol dipropionate | Cas No. 113-38-2. | |
| Estramustine phosphate sodium | Estramustine phosphate sodium is an antimicrotubule chemotherapy agent. It arrests prostate cancer cells in the G2/M phase of the cell cycle. Uses: Antineoplastic agents, hormonal. Synonyms: estramustine Phosphate, Emcyt, Estracyt, Leo-299; Ro 22-2296/000. Grades: >98%. CAS No. 52205-73-9. Molecular formula: C23H30Cl2NNa2O6P. Mole weight: 564.347. | |
| Estropipate | Estropipate is an estrogen receptor agonist used in post-menopausal women for hormonal replacement therapy, with benefits to improved cognition and prevention of osteoporosis. Also inhibits organic anion transporting polypeptide 1B1 (OATP1B1) (IC50= 70 nM. Uses: Used in post-menopausal women for hormonal replacement therapy, with benefits to improved cognition and prevention of osteoporosis. Synonyms: Piperazine estrone sulfate; 3-Sulfatoxyestra-1,3,5(10)-trien-17-one piperazine Salt. Grades: ≥96%. CAS No. 7280-37-7. Molecular formula: C18H22O5S.C4H10N2. Mole weight: 436.56. | |
| Etamicastat | Etamicastat is a selective dopamine β-hydroxylase (DBH) inhibitor. etamicastat can effectively decrease blood pressure, although can not prevent the development of hypertension in the spontaneously hypertensive rat. In Aug 2016, Phase-II for Hypertension in France was discontinued. Uses: Heart failure; hypertension. Synonyms: (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione;BIA 5-453;677773-32-9 (HCl salt). Grades: 98%. CAS No. 760173-05-5. Molecular formula: C14H15F2N3OS. Mole weight: 311.35. | |
| Etamicastat HCl salt | Etamicastat HCl salt is a potent, peripherally selective, reversible, dopamine β-hydroxylase inhibitor (DBH inhibitor). It effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat. It was developed by Bial-Portela and was in clinic phase 2 trials, but now it is terminated. Uses: Etamicastat hcl salt effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat. Synonyms: BIA5-453 HCl salt; BIA-5-453 HCl salt;(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride. Grades: 98%. CAS No. 677773-32-9. Molecular formula: C14H16ClF2N3OS. Mole weight: 347.81. | |
| Etamsylate | Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance and platelet adhesion. Synonyms: E 141; MD 141; E141; MD141; E-141; MD-141; Aglumin; Altodor; Eselin. Grades: >98%. CAS No. 2624-44-4. Molecular formula: C6H6O5S.C4H11N. Mole weight: 263.31. | |
| Etarfolatide | A folate receptor-targeting radiopharmaceutical consisting of a folate-containing tetrapeptide chelator to which technetium Tc 99m is linked. The folate component of folate receptor-targeted technetium Tc99m-EC20 binds to folic acid receptors, which are frequently upregulated in many types of tumor cells and activated macrophages. An investigational drug in clinical trials for the treatment of breast neoplasms, non small cell lung cancer (NSCLC), and adenocarcinoma of the lung. CAS No. 479578-27-3. Molecular formula: C29H34N10O11S. Mole weight: 730.71. | |
| ETC-159 | ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. Synonyms: ETC-159; ETC159; ETC 159; ETC-1922159; ETC 1922159; ETC1922159. Grades: 98%. CAS No. 1638250-96-0. Molecular formula: C19H19N7O3. Mole weight: 393.41. | |
| Ethacridine lactate monohydrate | Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent. Uses: Anti-infective agents, local. Synonyms: AMN-107; AMN107; AMN107. Grades: >98%. CAS No. 6402-23-9. Molecular formula: C15H15N3O·C3H6O3·H2O. Mole weight: 361.39. | |
| Ethisterone | Ethisterone is a progestogen hormone being considered to treat prostate cancer.It was the first orally-active progestin. Synonyms: Aethisteron; NSC 9565; NSC-9565; NSC9565; Progestoral; Ethisterone. Grades: >98%. CAS No. 434-03-7. Molecular formula: C21H28O2. Mole weight: 312.45. | |
| Ethosuximide | Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used for the treatment of Absence epilepsy and absence seizures. It may be used by itself or with other antiseizure medications such as valproic acid. Uses: Absence epilepsy;absence seizures. Synonyms: 3-Ethyl-3-methyl-2,5-pyrrolidinedione; 2-Ethyl-2-methylsuccinimide; Atysmal; Capitus; Emeside; Etosuximid; H 940; Mesentol; NSC 64013; Simatin; Succimal; Succimitin; Suxilep; Suximal. Grades: >95%. CAS No. 77-67-8. Molecular formula: C7H11NO2. Mole weight: 141.17. | |
| ETHOTOIN | Ethotoin is an anticonvulsant drug. It is a sodium channel inhibitor. Ethotoin can be used for the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Uses: Anticonvulsant drug. Synonyms: (±)-Ethotoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; AC-695; AC 695; AC695; Accenon; Peganone; 3-Ethyl-5-phenyl-2,4-Imidazolidinedione. Grades: 95%. CAS No. 86-35-1. Molecular formula: C11H12N2O2. Mole weight: 204.23. | |
| Ethyl 3-aminobenzoate methanesulfonate | Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels. It is mainly used as an anesthetic for fish and also used for the euthanasia of all fish species especially zebrafish, which is commonly used in research. Uses: Anesthetics. Synonyms: ethyl 3-aminobenzoate;methanesulfonic acid. Grades: 95 %. CAS No. 886-86-2. Molecular formula: C9H11NO2·CH4O3S. Mole weight: 261.29. | |
| Ethyl (E,4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-(furan-3-carbonylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate | A SARS-CoV Mpro inhibitor. Molecular formula: C32H49N5O8. Mole weight: 631.8. | |
| Ethyl-L-NIO hydrochloride | Ethyl-L-NIO is a modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 μM, respectively. Synonyms: L-N5-(1-Iminobutyl)ornithine hydrochloride. Grades: ≥95%. CAS No. 150403-97-7. Molecular formula: C9H19N3O2·HCl. Mole weight: 237.7. | |
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