BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
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Dybowskin-2
Dybowskin-2 has antibacterial and antifungal activity. The source of Dybowskin-2 is Rana dybowskii. Grade: >97% by HPLC.
Dybowskin-2CDYa
Dybowskin-2CDYa is an antimicrobial peptide. It has activity against the Gram-positive bacterium S.aureus (MIC=6 μM) and the Gram-negative bacterium E.coli (MIC=3 μM). Dybowskin-2CDYa lacks hemolytic activity against human erythrocytes. Grade: >96% by HPLC.
Dybowskin-2CDYb
Dybowskin-2CDYb is an antimicrobial peptide from Rana dybowskii.
Dybowskin-3
Dybowskin-3 is active against S. aureus, B. cereus, and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 50 uM). Synonyms: Brevinin-2DYc.
Dybowskin-4
Dybowskin-4 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. Grade: >96% by HPLC.
Dybowskin-5
Dybowskin-5 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. Grade: >96% by HPLC.
Dybowskin-6
Dybowskin-6 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii.
Dynorphin A (1-10) TFA
Dynorphin A (1-10) TFA is an endogenous opioid neuropeptide that binds to the extracellular loop 2 of the κ-opioid receptor. Synonyms: Dynorphin A (1-10) Trifluoroacetate; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-OH.TFA; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-proline Trifluoroacetate; Dynorphin A (1-10), porcine Trifluoroacetate. Grade: >98%. Molecular formula: C57H91N19O12.C2HF3O2. Mole weight: 1348.48.
Dynorphin A (1-13) amide
Dynorphin A (1-13) amide is an antagonist of human MC1, MC3 and MC4 receptors. Synonyms: Dynorphin A (1-13), amide, porcine; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-NH2; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-L-lysinamide; Linear Dyn A-(1-13)NH2; L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N5-(diaminomethylene)-L-ornithyl-N5-(diaminomethylene)-L-ornithyl-L-isoleucyl-N5-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-leucyl-L-lysinamide. Grade: ≥95%. CAS No. 79515-34-7. Molecular formula: C75H127N25O14. Mole weight: 1602.97.
Dynorphin A (2-12), porcine
Dynorphin A is an endogenous opioid peptide that preferentially activates κ opioid receptors. Synonyms: Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu. Molecular formula: C60H105N21O12. Mole weight: 1312.69.
E07LKK
E07LKK has antibacterial activity against S. aureus, E.coli.
E10KKL
E10KKL is a synthetic construct peptide. It has antibacterial activity.
E12LLK
E12LLK is a synthetic construct peptide. It has antibacterial activity.
E14KKL
E14KKL is a synthetic construct peptide. It has antibacterial activity.
E14LKK / H14LKK
E14LKK / H14LKK is a synthetic construct peptide. It has antibacterial activity.
E23GIG magainin 2
E23GIG magainin 2 is a synthetic construct peptide. It has antibacterial activity. Grade: >98% by HPLC.
E3 ligase Ligand-Linker Conjugates 30
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grade: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47.
E3 ubiquitin-protein ligase Mdm2 (53-60)
E3 ubiquitin-protein ligase Mdm2 (53-60) is a peptide derived from E3 ubiquitin-protein ligase Mdm2. The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel-Lindau tumor suppressor. Synonyms: Double minute 2 protein (53-60); RING-type E3 ubiquitin transferase Mdm2 (53-60); p53-binding protein Mdm2 (53-60).
E3 ubiquitin-protein ligase RNF43 (11-19(20))
A peptide fragment of E3 ubiquitin-protein ligase RNF43. E3 ubiquitin-protein ligase acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Synonyms: RING finger protein 43 (11-19(20)); RING-type E3 ubiquitin transferase RNF43 (11-19(20)).
E3 ubiquitin-protein ligase RNF43 (721-729)
A peptide fragment of E3 ubiquitin-protein ligase RNF43. E3 ubiquitin-protein ligase acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Synonyms: RING finger protein 43 (721-729); RING-type E3 ubiquitin transferase RNF43 (721-729).
E3 ubiquitin-protein ligase UBR4 (329-337)
E3 ubiquitin-protein ligase UBR4 (329-337) is a peptide derived from E3 ubiquitin-protein ligase UBR4. E3 ubiquitin-protein ligase is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Synonyms: RING-type E3 ubiquitin transferase UBR4 (329-337); Retinoblastoma-associated factor of 600 kDa (329-337).
E-76
E-76, a potent anticoagulant, is an inhibitor of coagulation factor VIIa. It acts by binding to an exosite on the VIIa protease domain and non-competitively inhibits the activation of factor X and amide hydrolytic activity. Synonyms: E-76; Acetyl-ALCDDPRVDRWYCQFVEG-amide; Ac-Ala-Leu-D-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bridge: Cys3-Cys13); N-acetyl-L-alanyl-L-leucyl-D-cysteinyl-L-alpha-aspartyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-valyl-L-alpha-aspartyl-L-arginyl-L-tryptophyl-L-tyrosyl-L-cysteinyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-alpha-glutamyl-glycinamide (3->13)-disulfide. Grade: ≥95% by HPLC. CAS No. 1926163-13-4. Molecular formula: C97H139N27O29S2. Mole weight: 2211.47.
EA-CATH1
EA-CATH1 has antibacterial activity. EA-CATH1 was found in Equus asinus. It appeared to be stable in serum and displayed no toxicity to human erythrocytes. Grade: >97% by HPLC.
EAFP1
EAFP1 is produced by Eucommia ulmoides. It has antifungal activity against P.infestans, A.lycopersici, V.dahliae, G.zeae, A.nicotianae, F.moniliforme, F.oxysporum and C.gossypii. Synonyms: Antifungal peptide 1.
EAFP2
EAFP2 is produced by Eucommia ulmoides. The inhibition activity of EAFP2 can be effective on both chitin-containing and chitin-free fungi. Synonyms: Antifungal peptide 2.
EAK16-II
EAK16-II is a self-assembled peptide that can form a stable β-sheet structure and can be used as a carrier or matrix for cell culture. Synonyms: Ac-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-NH2; L-Lysinamide, N-acetyl-L-alanyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-alanyl-. Grade: ≥95%. CAS No. 157675-61-1. Molecular formula: C70H121N21O25. Mole weight: 1656.84.
EAVRLFIEWLKNGGPSSGAPPPS
EAVRLFIEWLKNGGPSSGAPPPS is a polypeptide from patent CN 106029087 A. The incretin receptor ligands are derived from multiple skin toxicity Shan exosomes -3 skin of SDGTFTSDLSKQM Di EAVRLFIEWLKNGGPSSGAPPPS. Synonyms: Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser. Grade: >98%. Molecular formula: C110H169N29O32. Mole weight: 2409.75.
Ebecryl 3708 resin
Ebecryl 3708 resin is a modified bisphenol A epoxy bisacrylate with low viscosity and excellent curing reaction. Ebecryl 3708 resin films cured by ultraviolet light (UV) or electron beam (EB) show good flexibility, high gloss, toughness and excellent impact resistance. It can be used in clear coatings for paper, wood, flexible and rigid plastics, topcoats for wood and metal trim vehicles, adhesives for paper or film laminating, and lithography and screen ink vehicles.
Ecallantide
Ecallantide is a drug used for the treatment of hereditary angioedema and in the prevention of blood loss in cardiothoracic surgery. Synonyms: DX-88 cpd; EPI-KAL-2; Kalbitor. CAS No. 460738-38-9. Molecular formula: C305H442N88O91S8. Mole weight: 7053.83.
EcAMP1
EcAMP1 was shown to perform antifungal activity against several phytopathogenic fungi, with the most pronounced effect against members of the Fusarium genus.
EcAMP3
EcAMP3, a plant hairpin-like defense polypeptide isolated from the seeds of latent barnyard grass (Echinochloa crusgalli L.), has in vitro antifungal and antibacterial activities. Synonyms: H-Gly-Ala-Asp-Arg-Cys-Arg-Glu-Arg-Cys-Glu-Arg-Arg-His-Arg-Gly-Asp-Trp-Gln-Gly-Lys-Gln-Arg-Cys-Leu-Met-Glu-Cys-Arg-Arg-Arg-Glu-Gln-Glu-Glu-Asp-OH (Disulfide bridge: Cys5-Cys27, Cys9-Cys23). Grade: ≥95%. CAS No. 2243219-65-8. Molecular formula: C172H282N72O57S5. Mole weight: 4430.91.
EC-hepcidin3
EC-hepcidin3, a new four-cysteine hepcidin isoform gene, was cloned from the marine-cultured orange-spotted grouper (Epinephelus coioides).
EcLTP
EcLTP has antibacterial and antifungal activity. EcLTP was found in Echinochloa crusgalli L.
EC-proHep3
EC-proHep3 has strong, rapid activity against Staphylococcus aureus and Pseudomonas stutzeri. It was found in Epinephelus coioides.
EDDR1 (867-876)
EDDR1 (867-876) is a bioactive peptide of EDDR1. EDDR1, a membrane expressed protein associated with adhesion, has recently emerged as a new therapeutic target in several tumor types. Synonyms: Epithelial Discoidin Domain Receptor 1 (867-876).
Ee-CBP
Ee-CBP is a hevein-type antimicrobial peptide from bark of the spindle tree (Euonymus europaeus L.).
EEF2 (581-589)
EEF2 is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation. Synonyms: Eukaryotic Translation Elongation Factor 2 (581-589); Polypeptidyl-TRNA Translocase (581-589).
EFTUD2 is required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Synonyms: Elongation Factor Tu GTP Binding Domain Containing 2 (668-677); 116 KDa U5 Small Nuclear Ribonucleoprotein Component (668-677); Elongation Factor Tu GTP-Binding Domain-Containing Protein 2 (668-677).
A peptide fragment of EGF-R. Epidermal growth factor receptor (EGFR) is a prototypic cell-surface receptor belonging to the ErbB/HER onocogene family. Targeting of EGFR with specific blocking antibodies or inhibitors have been developing for treatment for EGFR-associated tumors. Synonyms: Epidermal growth factor receptor (1138-1147).
EGF Receptor Substrate 2 Phospho-Tyr5
EGF Receptor Substrate 2 Phospho-Tyr5 is a bioactive peptide derived from the autophosphorylation site (Tyr992) of the epidermal growth factor receptor (EGFR). Synonyms: H-Asp-Ala-Asp-Glu-pTyr-Leu-Ile-Pro-Gln-Gln-Gly-OH. Grade: ≥95%. Molecular formula: C54H82N13O24. Mole weight: 1328.28.
EGFRvIII peptide (PEPvIII)
EGFRvIII peptide (PEPvIII), a tumor-specific mutation and a target for anti-tumor immunotherapy, is widely expressed in glioblastoma multiforme (GBM) and other tumors, and its expression enhances tumorigenicity. Synonyms: H-Leu-Glu-Glu-Lys-Lys-Gly-Asn-Tyr-Val-Val-Thr-Asp-His-Cys-OH; L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysyl-glycyl-L-asparagyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-L-cysteine. Grade: ≥95%. CAS No. 129112-17-0. Molecular formula: C70H111N19O24S. Mole weight: 1634.81.
Egg Laying Hormone, aplysia
Egg Laying Hormone, aplysia is a neuropeptide containing 36 amino acids synthesized by the neurons of the bag cell, which can stimulate oviposition and ovulation in Aplysia by electrical discharge triggering of neurons. Egg Laying Hormone, aplysia induces a voltage-dependent slow inward current carried by Na+ in an identified motoneuron. Synonyms: Egg-laying hormone (Aplysia brasiliana bag cell); Ile-Ser-Ile-Asn-Gln-Asp-Leu-Lys-Ala-Ile-Thr-Asp-Met-Leu-Leu-Thr-Glu-Gln-Ile-Arg-Glu-Arg-Gln-Arg-Tyr-Leu-Ala-Asp-Leu-Arg-Gln-Arg-Leu-Leu-Glu-Lys-NH2; ELH, aplysia; L-Lysinamide, L-isoleucyl-L-seryl-L-isoleucyl-L-asparaginyl-L-glutaminyl-L-a-aspartyl-L-leucyl-L-lysyl-L-alanyl-L-isoleucyl-L-threonyl-L-a-aspartyl-L-methionyl-L-leucyl-L-leucyl-L-threonyl-L-a-glutamyl-L-glutaminyl-L-isoleucyl-L-arginyl-L-a-glutamyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosyl-L-leucyl-L-alanyl-L-a-aspartyl-L-leucyl-L-arginyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-a-glutamyl-. Grade: ≥95%. CAS No. 117680-39-4. Molecular formula: C190H329N59O57S. Mole weight: 4384.20.
Elamipretide TFA
Elamipretide TFA is a peptide that targets the mitochondrial intima and is an inhibitor of cardiolipin peroxidase. Synonyms: MTP-131 (TFA); RX-31 (TFA); SS-31 (TFA); (S)-6-Amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide 2,2,2-trifluoroacetate; D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide trifluoroacetic acid. Grade: ≥95%. CAS No. 1606994-55-1. Molecular formula: C34H50F3N9O7. Mole weight: 753.81.
Elamipretide triacetate
Elamipretide triacetate is an aromatic-cationic tetrapeptide that targets the mitochondrial intima and is an inhibitor of cardiolipin peroxidase. It easily penetrates cell membranes and has been used in therapeutic trials investigating Leber's Hereditary Optic Neuropathy. Synonyms: L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, acetate (1:3); SS-31 triacetate; H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2.3CH3CO2H; D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide acetic acid; D-Arg-2',6'-Dmt-Lys-Phe-NH2 triacetate. Grade: ≥95%. CAS No. 1849610-71-4. Molecular formula: C32H49N9O5.3C2H4O2. Mole weight: 819.95.
Elcatonin
Elcatonin is a calcitonin derivative used as an anti-parathyroid agent. Synonyms: Elcatonin Acetate. Grade: 98%. CAS No. 60731-46-6. Molecular formula: C148H244N42O47. Mole weight: 3363.82.
ENAP-1
ENAP-1 has antimicrobial activity against Gram-negative and Gram-positive bacteria.
eNAP-2
ENAP-2 is a novel cysteine-rich bactericidal peptide from equine leukocytes.
Endo-38a-Pro-Exenatide
Endo-38a-Pro-Exenatide is an impurity of exenatide. Synonyms: Endo-38a-Exendin-4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Pro-Ser-NH2. Grade: ≥95%. CAS No. 1678416-95-9. Molecular formula: C189H289N51O61S. Mole weight: 4283.75.
Endopeptidase L4
Endopeptidase L4 is an antibacterial peptide produced by Lysobacter sp. (strain XL1).
Endotoxin Substrate
Endotoxin Substrate is a chromogenic substrate for horseshoe crab clotting enzyme, which is used in quantitative assays of endotoxin. Synonyms: Boc-LGR-pNA. CAS No. 68223-96-1. Molecular formula: C25H40N8O7. Mole weight: 564.63.
Endotrophin (mouse)
Endotrophin, a carboxy-terminal cleavage product of the collagen 6α-3 chain produced and released by adipocytes, is greatly upregulated in malignant tumors of the breast, liver colon and pancreas. Endotrophin provides a link between obesity and aggressive tumor growth and may serve as a sensitive diagnostic marker and effective therapeutic target for designing better treatments for cancer and improving obesity-induced insulin resistance. Synonyms: H-Thr-Glu-Pro-Leu-Phe-Leu-Thr-Lys-Thr-Asp-Ile-Cys-Lys-Leu-Ser-Arg-Asp-Ala-Gly-Thr-Cys-Val-Asp-Phe-Lys-Leu-Leu-Trp-His-Tyr-Asp-Leu-Glu-Ser-Lys-Ser-Cys-Lys-Arg-Phe-Trp-Tyr-Gly-Gly-Cys-Gly-Gly-Asn-Glu-Asn-Arg-Phe-His-Ser-Gln-Glu-Glu-Cys-Glu-Lys-Met-Cys-Ser-Pro-Glu-Leu-Thr-Val-OH (Disulfide bridge: Cys12-Cys62, Cys21-Cys45, Cys37-Cys58, air oxidized). Grade: ≥95%. CAS No. 1678414-54-4. Molecular formula: C345H520N92O106S7. Mole weight: 7876.94.
Enhancer of rudimentary homolog
ERH is a small, highly conserved protein that has been found in Sus scrofa. It has antibacterial activity. Synonyms: ERH.
Enkelytin
The antibacterial spectrum shows that enkelytin is active against several Gram-positive bacteria including Staphylococcus aureus, but it is unable to inhibit the Gram-negative bacteria growth.
Enterocin 1071 A
Enterocin 1071 A is isolated from Enterococcus faecalis BFE 1071 and has antibacterial activity. Synonyms: Enterocin EntC1 peptide.
Enterocin 7B
Purified Ent7B is active against spoilage microorganisms and foodborne pathogens, including Clostridium sporogenes, Listeria monocytogenes, and Staphylococcus aureus as well as Brevundimonas diminuta, which has been associated with infections among immune-suppressed cancer patients. Synonyms: Ent7B.
Enterocin A
Enterocin A is a classic IIa bacteriocin isolated firstly from Enterococcus faecium CTC492 with selective antimicrobial activity against Listeria strains. However, the application of enterocin A as an anti-Listeria agent has been limited due to its very low native yield. Synonyms: EntA. Molecular formula: C49H70N14O16. Mole weight: 1111.2.
Enterocin B
Enterocin B is a new bacteriocin from Enterococcus faecium T136 which can act synergistically with enterocin A.
Enterocin EJ97
Enterocin EJ97 is active on several gram-positive bacteria including enterococci, several species of Bacillus, Listeria, and Staphylococcus aureus. Enterocin EJ97 also has a concentration-dependent bactericidal and bacteriolytic effect on E. faecalis S-47. Synonyms: Enterocin EJ97. Molecular formula: C88H144N20O18S2. Mole weight: 5340.
Enterocin-HF
Enterocin HF is an antilisterial bacteriocin produced by Enterococcus faecium M3K31. Synonyms: EntHF.
Enterocin L50A
Enterocin L50A is an antibacterial peptide isolated from Enterococcus faecium. Synonyms: EntL50A.
Enterocin L50B
Enterocin L50B is an antibacterial peptide isolated from Enterococcus faecium. Synonyms: EntL50B.
Enterocin NKR-5-3D
Enterocin NKR-5-3D is active against select Gram-positive bacteria. In addition, it induces the production of other entericins such as NKR-5-3A, NKR-5-3B, and NKR-5-3C. Enterocin NKR-5-3D was found in Enterococcus faecium. Grade: >95% by HPLC.
Enterocin P precursor
Enterocin P precursor is an antibacterial peptide isolated from Enterococcus faecium. Synonyms: preEntP.
Enterocin Q
Enterocin Q is an antibacterial peptide isolated from Enterococcus faecium.
Enterocin RJ-11
Enterocin RJ-11 is an antibacterial peptide isolated from Enterococcus faecium. Enterocin RJ-11 also effectively inhibited a spore-forming Bacillus that often contaminates food production processes.