BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Cobimetinib racemate | Cobimetinib racemate is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Synonyms: GDC-0973 racemate; XL-518; GDC 0973 racemate; XL 518; GDC0973 racemate; XL518. Grades: >98%. CAS No. 934662-91-6. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31. |  |
| Cobimetinib (R-enantiomer) | Cobimetinib (R-enantiomer) is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Synonyms: GDC-0973 R-enantiomer; XL-518 R-enantiomer; GDC0973 R-enantiomer; XL518 R-enantiomer; GDC 0973 R-enantiomer; XL 518 R-enantiomer. Grades: >98%. CAS No. 934660-94-3. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31. | |
| Colterol acetate | Colterol acetate is a short-acting β2-adrenoreceptor agonist. Bitolterol is the prodrug of Colterol used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Synonyms: 4-(2-tert-Butylamino-1-hydroxyethyl)-benzene-1,2-diol acetate. CAS No. 10255-14-8. Molecular formula: C14H23NO5. Mole weight: 285.336. | |
| Combretastatin | Combretastatin is a dihydrostilbenoid that found in Combretum caffrum. Members of the combretastatin family shows varying ability to cause vascular disruption in tumors. Combretastatin can bind to the β-subunit of tubulin. It is a tubulin polymerisation inhibitor and can be used for the treatment of tumor. Uses: Tumor. Synonyms: COMBRETASTATIN;(R)-(-)-Combretastatin;(R)-3-Hydroxy-4-methoxy-α-(3,4,5-trimethoxyphenyl)benzeneethanol;2-Methoxy-5-[(βR)-β-hydroxy-3,4,5-trimethoxyphenethyl]phenol;5-[(R)-2-Hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol. Grades: 95%. CAS No. 82855-09-2. Molecular formula: C18H22O6. Mole weight: 337.37. | |
| Compound 48/80 hydrochloride | Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells. Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C. Synonyms: 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine trihydrochloride. Grades: ≥95%. CAS No. 848035-21-2. Molecular formula: C32H45N3O3·3HCl. Mole weight: 629.1. | |
| Compound 56 | Compound 56 is a highly potent inhibitor of the epidermal growth factor receptor (EGFR; IC50 = 0.006 nM). It has been used to inhibit EGFR activity in pancreatic cancer cell lines and it can induce the differentiation of rat mesenchymal stem cells. Synonyms: N-(3-bromophenyl)-6,7-diethoxy-4-quinazolinamine. Grades: ≥95%. CAS No. 171745-13-4. Molecular formula: C18H18BrN3O2. Mole weight: 388.3. | |
| Compound E | Compound E is a cell-permeable inhibitor of γ-secretase (GSI), which is a multifunctional transmembrane protein complex enzymatically catalyzing the cleavage of single-pass transmembrane proteins. Compound E can inhibit Notch processing (IC50 = 2.2 nM in SupT1 cells) and β-ammyloid production in cell culture (IC50 = 0.3 nM). Synonyms: γ-Secretase Inhibitor; Gamma-Secretase Inhibitor XXI; (S,S)- 2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide; (2S)-2-{[(3,5-Difluorophenyl)acetyl]amino}-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide; N2-[(3,5-difluorophenyl)acetyl]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-L-alaninamide. Grades: 99%. CAS No. 209986-17-4. Molecular formula: C27H24F2N4O3. Mole weight: 490.5. | |
| Compound W | Compound W, also called 3,5-bis(4-Nitrophenoxy)benzoic acid, a 3,3'-diiodothyronine sulfate cross-reactive substance, is an inhibitor of γ-secretase which causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). Synonyms: 3,5-bis(4-Nitrophenoxy)benzoic acid; 173550-33-9; gamma-Secretase Modulator, CW; ACMC-1CUIP; SCHEMBL264541; CHEMBL1553155; CTK8B1007; JOSXKPZXMVHRKU-UHFFFAOYSA-; DTXSID10587892; JOSXKPZXMVHRKU-UHFFFAOYSA-N; HMS3269J17; ZINC2576957; ANW-22664; MFCD02093450; AKOS015833412; 3,5-bis (4-nitrophenoxy) benzoic acid; NCGC00167814-01; AJ-42568; AK-63150; EN002659; OR182673; KB-234083; TR-007681; B2120; Compound W|CW|3,5-Bis(4-nitrophenoxy)benzoic acid; BRD-K98143539-001-01-4; I14-62910. Grades: >98.0%(T)(HPLC). CAS No. 173550-33-9. Molecular formula: C19H12N2O8. Mole weight: 396.31. | |
| Conessine | Conessine is a naturally occurring steroidal dibasic alkaloid with a rigid steroid-based skeleton. It is found in a number of plant species from the apocynaceae family. It is a selective, specific and potent histamine H3 receptor antagonist. It has high selectivity for both rat and human histamine H3 receptors. It has a poor rate of CNS clearance. It also binds to the human α2C4 adrenergic receptor. It has anti-malarial activity and displays in vitro antiplasmodial activity. It is used as a treatment for amoebic dysentery. It was developed by Abbott. Synonyms: Conessine; Conessinum; Konessin; Neriine; Roquessine; Wrightine; (3R, 3aR, 5aR, 5bR, 9R, 11aS, 11bR, 13aR)-N, N, 2, 3, 11a-pentamethyl-2, 3, 3a, 4, 5, 5a, 5b, 6, 8, 9, 10, 11, 11a, 11b, 12, 13-hexadecahydro-1H-naphtho[2', 1':4, 5]indeno[1, 7a-c]pyrrol-9-amine; (3β)-N,N-dimethyl-con-5-enin-3-amine; NSC 119994; Neriine; Roquessine; Wrightine; N,18-Dihydrotrimethylconkurchine; (+)-Conessine; N',18-Dihydro-N,N,N'-trimethylconkurchine; (3β)-N,N-Dimethylcon-5-enin-3-amine; 3β-(Dimethylamino)con-5-enine; N,N-Dimethyl-con-5-enin-3-amine. CAS No. 546-06-5. Molecular formula: C24H40N2. Mole weight: 356.59. | |
| Conivaptan | Conivaptan, also called as YM 087 or Vaprisol, is the first is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) approved by United States Federal Drug Administrations (FDA) for the treatment of hyponatremia. Synonyms: [1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-; N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide; ZINC 12503187; N-(4-(2-methyl-3,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide. Grades: 95%. CAS No. 210101-16-9. Molecular formula: C32H26N4O2. Mole weight: 498.58. | |
| copanlisib hydrochloride | Copanlisib hydrochloride is a potent inhibitor of Class I phosphoinositide 3-kinase which showed a therapeutic effect on non-Hodgkin lymphoma. It was approved to treat follicular lymphoma that has relapsed after treatment with at least two other anticancer therapies. Uses: The potential treatment of non-hodgkin lymphoma. Synonyms: BAY 80-6946 dihydrochloride; BAY 80 6946 dihydrochloride; BAY 806946 dihydrochloride; Copanlisib hydrochloride; Aliqopa; Copanlisib dihydrochloride; UNII-03ZI7RZ52O; 03ZI7RZ52O; BAY 80-6946 dihydrochloride; BAY-80-6946 dihydrochloride. CAS No. 1402152-13-9. Molecular formula: C23H30Cl2N8O4. Mole weight: 553.445. | |
| CoPo 22 | CoPo 22 is a corrector and potentiator for ?F508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel function in cystic fibrosis. Synonyms: CoPo 22; CoPo22; CoPo-22; ASN 06744166; ASN06744166; ASN-06744166; N-(2-((3-Cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-3-methoxybenzamide; N-[2-[(3-cyano-5,7-dimethylquinolin-2-yl)amino]ethyl]-3-methoxybenzamide. Grades: 99%. CAS No. 606101-83-1. Molecular formula: C22H22N4O2. Mole weight: 374.44. | |
| Coptisine | Coptisine exerts a strong anti-osteosarcoma effect with very low toxicity and is a potential anti-osteosarcoma drug candidate. Uses: Anti-osteosarcoma. Synonyms: COPTISINE; Coptisin; 5, 6-Dihydro-2, 3:9, 10-bis(methylenedioxy)dibenzo[a, g]quinolizinium; 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium; Coptisine Sulfate; COPTISINE(P); Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-. Grades: >98%. CAS No. 3486-66-6. Molecular formula: C19H14NO4. Mole weight: 320.32. | |
| Coptisine chloride | Coptisine chloride and BRB can be absorbed across intestinal epithelial cells, and they are completely absorbed compounds. Uses: Anti-osteosarcoma. Synonyms: 2,3,9,10-BISMETHYLENEDIOXYPROTOBERBERINE; COPTISINE CHLORIDE; COPTISINE CHLORIDE(P); 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride; Coptisine Hcl; Coptisine Hydrochloride; COPTISINECHLORIDE(P)(PLEASECALL); 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoliziniuM Chloride. Grades: >98%. CAS No. 6020-18-4. Molecular formula: C19H14NO4Cl. Mole weight: 355.77. | |
| COR 170 | COR 170 has been found to be an inverse agonist of CB2 receptors and could be used in studies for CB1 and CB2 receptor affinity. Synonyms: COR-170; COR 170; COR170; N-(Adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide. Grades: ≥99% by HPLC. CAS No. 1048039-15-1. Molecular formula: C31H36N2O2. Mole weight: 468.63. | |
| Cortagine | Cortagine is a selective and potent corticotrophin releasing factor receptor 1 (CRF1) agonist with EC50 value of 0.18 nM for rat CRF1. It shows antidepressant and anxiolytic activity in the mouse model. Synonyms: cortagine; DC41887. Molecular formula: C192H323N55O63S. Mole weight: 4442.06. | |
| Corticosterone | Extract from the adrenal cortex, is a sensitive inhibitor of monoamine transport. Uses: A sensitive inhibitor of monoamine transport. Synonyms: Corticosterone; BRN 2339601; BRN-233960; BRN233960; CCRIS 6753; CCRIS-6753; CCRIS6753; NSC 9705; NSC-9705; NSC9705; (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one. Grades: ≥98%. CAS No. 50-22-6. Molecular formula: C21H30O4. Mole weight: 346.46. | |
| Cortistatin-14 trifluoroacetate salt | Cortistatin-14 (TFA) is a neuropeptide which is structural similar to somatostatin-14 and it binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties. Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells). Grades: ≥95%. Molecular formula: C81H113N19O19S2·xCF3COOH. Mole weight: 1721.01. | |
| Cortodoxone | Cortodoxone, a glucocorticoid receptor antagonist, is an intermediate which can be oxygenated to cortisol. Uses: Glucocorticoid receptor binding. Synonyms: (8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 11 Deoxycortisol 11 Desoxycortisol 11 Desoxycortisone 11-Deoxycortisol 11-Desoxycortisol 11-Desoxycortisone Cortexo. Grades: >98.0%(LC). CAS No. 152-58-9. Molecular formula: C21H30O4. Mole weight: 346.46. | |
| Corydaline | Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. Corydaline exhibits the antiacetylcholinesterase, antiallergic, antinociceptive, and gastric emptying activities. Uses: Antiacetylcholinesterase, antiallergic, antinociceptive. Synonyms: (13s-e)-thyl; 2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin; 2,3,9,10-tetramethoxy-13-methyl-berbin; 6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me; corydalin; (+) CORYDALINE; CORYDALINE; CORYDALINE, (+). Grades: >98%. CAS No. 518-69-4. Molecular formula: C22H27NO4. Mole weight: 369.44. | |
| COTI-2 | COTI-2 is an p53 gene activator and the PI3K/AKT/mTOR pathway inhibitor. COTI-2 induces apoptosis and suppresses proliferation of a wide variety of human cancer cell lines in vitro. Synonyms: COTI-2; COTI2; COTI 2. 2BTA1O65BR; ZINC114475331; CS-8156; CS 8156; CS8156; N-[(E)-6,7-dihydro-5H-quinolin-8-ylideneamino]-4-pyridin-2-ylpiperazine-1-carbothioamide. Grades: 99%. CAS No. 1039455-84-9. Molecular formula: C19H22N6S. Mole weight: 366.48. | |
| COX/5-LO-IN-1 | A dual inhibitor of cylooxygenase and 5-lipoxygenase. Synonyms: Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-; 1-[4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. CAS No. 154355-75-6. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
| CP-?060 | CP-060 is a novel type of Ca(2+) antagonist possessing both Ca(2+) overload inhibition, with antioxidant and cardioprotective activities. Synonyms: CP-060; CP060; CP 060; 3-[3-[2-(1,3-benzodioxol-5-yloxy)ethyl-methylamino]propyl]-2-(3,5-ditert-butyl-4-hydroxyphenyl)-1,3-thiazolidin-4-one. CAS No. 180090-15-7. Molecular formula: C30H42N2O5S. Mole weight: 542.73. | |
| CP 101606 | CP 101606 is a potent and selective NR2B antagonist of N-Methyl-D-Aspartate (NMDA) glutamate receptors. It decreases pentylenetetrazol-induced seizures. Synonyms: CP-101606; CP 101606; CP101606; Traxoprodil; 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol. Grades: 99%. CAS No. 134234-12-1. Molecular formula: C20H25NO3. Mole weight: 327.42. | |
| CP-105696 | CP-105696, a chromen derivative, has been found to be a leukotriene B4 receptor antagonist that was once studied against sorts of nflammatory disease. Uses: Leukotriene antagonists. Synonyms: CP-105696; UNII-Z7354TW4BM; CP-105,696; CHEMBL51770; CP 105696; Z7354TW4BM; 1-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]cyclopentane-1-carboxylic acid. Grades: 98%. CAS No. 158081-99-3. Molecular formula: C28H28O4. Mole weight: 428.53. | |
| CP-114271 | CP-114271, a thiazole derivative, has been found to be a β3 adrenergic receptor agonist that was once studied in obesity therapy. Synonyms: CP-114271; CP 114271; CP114271; UL-TG 307; UL-TG-307; UNII-CY8W406YBX.; UL-TG 307; UL-TG-307; CY8W406YBX; Acetic acid, (4- ( (2R) -2- ( ( (2S) -2-hydroxy-2- (2- (trifluoromethyl) -4-thiazolyl) ethyl) amino) propyl) phenoxy) -. Grades: 98%. CAS No. 162326-86-5. Molecular formula: C17H19F3N2O4S. Mole weight: 404.40. | |
| CP 117227 | CP 117227, a dibenzocyclohepten derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in studies of anticancer. Synonyms: CP 117227; CP-117227; CP117227; 1-Piperazineethanol, 4-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)-alpha-((5-quinolinyloxy)methyl)-, (S)-. Grades: 98%. CAS No. 154531-78-9. Molecular formula: C31H33N3O2. Mole weight: 479.61. | |
| CP 154526 | The hydrochloride salt form of CP-154526, which has been found to be a non-peptide CRF1 receptor antagonist and could exhibit anxiolytic-like activity at some extent. Synonyms: CP 154526; CP154526; CP-154526; N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 257639-98-8. Molecular formula: C23H32N4.HCl. Mole weight: 400.99. | |
| CP-195494 | CP-195494, a benzothiazol derivative, was once studied as a leukotriene receptor antagonist. Synonyms: UNII-1D055URF6U; CHEMBL300701; CP195494; CP 195494; CP-195494; (+)-CP-195494; 1D055URF6U; BDBM50070919. Grades: 98%. CAS No. 158103-57-2. Molecular formula: C26H22F4N2O5S2. Mole weight: 582.59. | |
| CP-195543 | CP-195543 is a potent and selective leukotriene B4 antagonist developed as an oral treatment for for inflammatory diseases. Synonyms: 2-[(3S,4R)-3-benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-4-(trifluoromethyl)benzoic acid; 2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid; CP 195543; CP-195543; CP195543. Grades: >98%. CAS No. 204981-48-6. Molecular formula: C24H19F3O4. Mole weight: 428.4. | |
| CP-199330 | CP-199330, a chromen derivative, has been found to be a Leukotriene D4 receptor antagonist that was once studied against asthma by Pfizer. Synonyms: CP-199330; CP 199330; CP199330; UNII-V4WYK6T8QA; CHEMBL96206; V4WYK6T8QA; SCHEMBL8890632; BDBM50081532; N-[3-[[(3R,4R)-6-[(7-chloroquinolin-2-yl)methoxy]-4-hydroxy-3,4-dihydro-2H-chromen-3-yl]methyl]-4-methoxyphenyl]-1,1,1-trifluoromethanesulfonamide. Grades: 98%. CAS No. 158102-92-2. Molecular formula: C28H24ClF3N2O6S. Mole weight: 609.01. | |
| CP-199330 Sodium | The sodium salt form of CP-199330 which is a chromen derivative and has been found to be a Leukotriene D4 receptor antagonist that was once studied against asthma by Pfizer. Synonyms: CP-199330 sodium; CP 199330 sodium; CP199330 sodium; CP-199330 monosodium salt; Methanesulfonamide, N-(3-((6-((7-chloro-2-quinolinyl)methoxy)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-3-yl)methyl)-4-methoxyphenyl)-1,1,1-trifluoro-, monosodium salt, (3R-cis)-; UNII-74573Q728X component FZCWCSNK. Grades: 98%. CAS No. 158102-98-8. Molecular formula: C28H23ClF3N2NaO6S. Mole weight: 630.99. | |
| CP2 | CP2 is a cyclic peptide and it is an inhibitor of the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. Grades: ≥97%. Molecular formula: C92H120N24O26S. Mole weight: 2010.15. | |
| CP 226269 | CP 226269 is a selective dopamine D4 agonist. Synonyms: CP-226269; CP 226269; CP226269; 5-fluoro-2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-indole. Grades: 99%. CAS No. 220941-93-5. Molecular formula: C18H19FN4. Mole weight: 310.37. | |
| CP-283097 | CP-283097 is NR2B N-Methyl-D-Aspartate receptor antagonist originated by Pfizer. Preclinical trials for the treatment of Migraine and Neurodegenerative disorders were discontinued. Uses: Migraine; neurodegenerative disorders. Synonyms: CP-283097; CP283097; CP 283097; UNII-WHL1Z3GN15;;(3R,4S)-Rel-3,4-dihydro-3-(4-hydroxy-4-(phenylmethyl)-1-piperidinyl)-2H-1-benzopyran-4,7-diol. Grades: 98%. CAS No. 138047-56-0. Molecular formula: C21H25NO4. Mole weight: 355.43. | |
| CP-316311 | CP-316311, a pyridine derivative, has been found to be a CRF 1 receptor antagonist and was once studied as an antidepressant agent by Pfizer. IC50: 6.8 nM. Synonyms: CP-316311; CP 316311; CP316311; CP-316,311; CP 316,311; CP316,311; Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-. Grades: 98%. CAS No. 175139-41-0. Molecular formula: C21H29NO2. Mole weight: 327.47. | |
| CP 316819 | CP 316819 has been found to be a glycogen phosphorylase inhibitor and could probably be used in the treatment for glycemic control in type 2 diabetes. Synonyms: CP 316819; CP316819; CP-316819; 5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 186392-43-8. Molecular formula: C21H22ClN3O4. Mole weight: 415.87. | |
| CP-320626 | CP-320626, a carboxamide derivative, is a potent glycogen phosphorylase inhibitor and a possible target for type 2 diabetes therapy. CP-320626 is also a potent inhibitor of human muscle GPa. Synonyms: 5-chloro-N-[(2S)-3-(4-fluorophenyl)-1-(4-hydroxypiperidin-1-yl)-1-oxopropan-2-yl]-1H-indole-2-carboxamide;CP-320626; CP320626; CP 320626. Grades: >98%. CAS No. 186430-23-9. Molecular formula: C23H23ClFN3O3. Mole weight: 443.90. | |
| CP-331684 | CP-331684 is a β3-adrenergic receptor agonist used as antidiabetic drug. Synonyms: CP-331684; CP331684; CP 331684; UNII-9EY0MGZ7F8. 2- [4- [2- [ [ (2R) -2- (6-aminopyridin-3-yl) -2-hydroxyethyl] amino] ethoxy] phenyl] acetic acid. Grades: >98%. CAS No. 207922-70-1. Molecular formula: C17H21N3O4. Mole weight: 331.37. | |
| CP 339818 hydrochloride | CP 339818 hydrochloride is the hydrochloride salt form of CP 339818, a non-peptide KV1.3 channel antagonist that is more effective at blocking HCN1 than HCN4. Synonyms: 1-Pentanamine, N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-, hydrochloride (1:1); 1-Pentanamine, N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-, monohydrochloride; Cp 339818 monohydrochloride; N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride; (1-Benzyl-1H-quinolin-4-ylidene)-pentyl-amine hydrochloride; 1-Benzyl-N-pentylquinolin-4(1H)-imine hydrochloride; N-(1-Benzylquinolin-4(1H)-ylidene)pentan-1-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 478341-55-8. Molecular formula: C21H24N2.HCl. Mole weight: 340.89. | |
| CP-376395 HCl | CP-376395 HCl is a potent and selective CRF1 receptor antagonist with Ki values of 12 and >10000 nM for CRF1 and CRF2 receptors respectively. It attenuates CRF-induced activation of the HPA axis in vivo. Synonyms: CP376395 HCl; CP 376395 HCl; 2-(Mesityloxy)-3,6-dimethyl-N-(pentan-3-yl)pyridin-4-amine hydrochloride;3,6-Dimethyl-N-pentan-3-yl-2-(2,4,6-trimethylphenoxy)pyridin-4-amine hydrochloride. Grades: >98 %. CAS No. 1013933-37-3. Molecular formula: C21H31ClN2O. Mole weight: 362.94. | |
| CP-409092 | CP-409092 is a GABA(A) partial agonist developed for the treatment of General Anxiety Disorder (GAD) and presents an interesting phenomenon of human pharmacokinetic predictions. In vitro, CP-409092 was abroadly metabolized in rat and human systems predominantly to acid metabolite formed by oxidative deamination of the N-methyl group of CP-409092 mediated by MAO-A (as deduced from inhibition experiments). Synonyms: N-[4-(methylaminomethyl)phenyl]-4-oxo-1,5,6,7-tetrahydroindole-3-carboxamide; 4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (4-methylaminomethylphenyl)amide; CP 409,092; CP 409092; CP-409,092; CP-409092; CP409,092; CP409092. Grades: >98%. CAS No. 194098-25-4. Molecular formula: C17H19N3O2. Mole weight: 297.35. | |
| CP-457677 | CP-457677, also called as TX006169, is a JNK inhibitor. Synonyms: 2-(4-fluorophenoxy)-N-[[4-(2-hydroxypropan-2-yl)phenyl]methyl]pyridine-3-carboxamide; CP-457677; CP457677; CP 457677; UNII-5A83419M4U. Grades: >98%. CAS No. 214535-77-0. Molecular formula: C22H21FN2O3. Mole weight: 380.41. | |
| CP-457920 | CP-457920, also called as NGD 971, is a selective α5 GABAA receptor inverse agonist (Ki of ~ 1 ng/mL). CP-457920 was progressed into clinical studies for the treatment of Vascular dementia but discontinued. Synonyms: N-benzyl-6-ethoxy-4-oxo-1H-1,5-naphthyridine-3-carboxamide; CP-457920; CP457920; CP 457920; UNII-13BME2F602; CP-457,920. Grades: >98%. CAS No. 220860-50-4. Molecular formula: C18H17N3O3. Mole weight: 323.35. | |
| CP 461 | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. N-benzyl-2-[6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide;hydrochloride; CAS: 227619-92-3 (CP-461 free base). Grades: >98%. CAS No. 227619-96-7. Molecular formula: C25H22ClFN2O. Mole weight: 420.91. | |
| CP-461 free base | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP-461 free base; CP 461 free base; CP461 free base; N-benzyl-2-[(3Z)-6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide; UNII-824ZMS3BGL; OSI-461 free base. Grades: >98%. CAS No. 227619-92-3. Molecular formula: C25H21FN2O. Mole weight: 384.45. | |
| CP 465022 | CP 465022, with anticonvulsant activity, is a potent, brain penetrant, orally active and selective noncompetitive AMPA receptor antagonist (IC50 = 25 nM in rat cortical neurons). CP 465022 provides neuroprotective efficacy after cerebral ischemia on the basis of the activity in experimental ischemia models. Synonyms: 3-(2-chlorophenyl)-2-[2-[6-(diethylaminomethyl)pyridin-2-yl]ethenyl]-6-fluoroquinazolin-4-one; CP-465022; CP 465022; CP465022; UNII-4582JTR93Y. Grades: >99 %. CAS No. 199655-36-2. Molecular formula: C26H24ClFN4O. Mole weight: 499.41. | |
| CP-465022 maleate | CP-465022 is a selective, non-competitive AMPA antagonist that displays potent anticonvulsant activity. Synonyms: CP-465022 (maleate); 199656-46-7; cp-465022 maleate; (Z)-but-2-enedioic acid; 3-(2-chlorophenyl)-2-[(E)-2-[6-(diethylaminomethyl)pyridin-2-yl]ethenyl]-6-fluoroquinazolin-4-one; CP-392,110 (maleate); 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone-(2Z)-2-butenedioate; SCHEMBL8301393; CP465022(2Z)-2-butenedioate; ZHA65646; HY-18663A; AKOS037643494; CP 465022 (2Z)-2-butenedioate; AS-16611; CS-0013530. CAS No. 199656-46-7. Molecular formula: C26H24ClFN4O·C4H4O4. Mole weight: 579. | |
| CP 471474 | CP 471474 a broad spectrum Matrix Metalloprotease inhibitor with sub-nanomolar affinity for MMP-2 and 13 among MMPs (IC50: 1170, 0.7, 16, 13, 0.9 for MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13 respectively). Synonyms: CP-471474; CP 471474; CP471474; UNII-96U47H947L; 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide; CP 471474; CP-471474; 210755-45-6; CHEMBL323612. Grades: >97 %. CAS No. 210755-45-6. Molecular formula: C16H17FN2O5S. Mole weight: 368.38. | |
| CP-481715 | CP-481715 is a potent and selective CCR1 antagonist with >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related chemokine receptors. CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice. Synonyms: N-[(2S,3S,5R)-5-carbamoyl-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl]quinoxaline-2-carboxamide; CP 481,715; CP 481715; CP-481,715; CP-481715; CP481,715; CP481715; quinoxaline-2-carboxylic acid (4-carbamoyl-1-(3-fluorobenzyl)-2,7-dihydroxy-7-methyloctyl)amide. Grades: >98%. CAS No. 212790-31-3. Molecular formula: C26H31FN4O4. Mole weight: 482.55. | |
| CP-532623 | CP-532623, structurally related to Torcetrapib, is a potent inhibitor of cholesteryl ester transfer protein (CETP). Synonyms: CP-532623; CP 532623; CP532623; UNII-5KK52HG8D; 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile. Grades: >98%. CAS No. 261947-38-0. Molecular formula: C27H27F9N2O3. Mole weight: 598.5. | |
| CP-533536 | CP-533536, also called as Evatanepag, a 3-pyridyl sulfonamide compound, demonstrated excellent in vitro potency against prostaglandin E2 (PGE2) (induces local bone formation with EC50= 0.3 nM) and selectivity against a broad panel of other targets. Synonyms: 2- [3- [ [ (4-tert-butylphenyl) methyl-pyridin-3-ylsulfonylamino] methyl] phenoxy] acetic acid(3-((4-tert-butylbenzyl)-(pyridine-3-sulfonylamino)methyl)phenoxy)acetic acidCP-533536; CP 533536; CP533536; Evatanepag. Grades: 95%. CAS No. 223488-57-1. Molecular formula: C25H28N2O5S. Mole weight: 468.56. | |
| CP 544326 | CP 544326, also known as taprenepag, is a potent and selective EP(2) receptor agonist. Its EC50 value is 2.8 nM. It is the active acid metabolite of the prodrug PF-04217329. It was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma. Uses: Cp 544326 was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma. Synonyms: CP-544326; CP544326, CP544326, Taprenepag, PF-0421732 metabolite; 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid; CP-544326; CP544326; CP544326; Taprenepag; PF-0421732 metabolite. Grades: 98%. CAS No. 752187-80-7. Molecular formula: C24H22N4O5S. Mole weight: 478.52. | |
| CP-544439 | CP-544439 is a selective matrix metalloproteinase-13 inhibitor. Uses: Matrix metalloproteinase inhibitors. Synonyms: 4-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxyoxane-4-carboxamide; CP-544439; CP 544439; CP544439 ; UNII-516DO4KL5R. Grades: >98%. CAS No. 230954-09-3. Molecular formula: C18H19FN2O6S. Mole weight: 410.42. | |
| CP-547632 | CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor , and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies. Synonyms: CP547632; CP 547632; CP-547632; PAN90806; PAN 90806; PAN-90806; CP632; OSI632; CP 632; OSI 632; CP-632; OSI-632. CAS No. 252003-65-9. Molecular formula: C20H24BrF2N5O3S. Mole weight: 532.405. | |
| CP-5609 | CP-5609 is a novel carbapenem with enhanced antimicrobial activities. Uses: Antimicrobial activities. Synonyms: CP-5609; CP 5609; CP5609; ME-1036; ME 1036;ME1036; UNII-33501R83O2. Pyridinium, 1-(2-amino-2-oxoethyl)-3-((2-((4S,5R,6S)-2-carboxy-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-en-3-yl)imidazo(5,1-b)thiazol-7-yl)carbonyl)-, inner salt. Grades: ≥95%. CAS No. 432038-96-5. Molecular formula: C23H21N5O6S. Mole weight: 495.51. | |
| CP 59430 | CP 59430 is an azide analog of prazosin. It is a selective alpha 1-adrenergic receptor antagonist. Synonyms: CP 59430; CP59430; CP-59430. 2-(4-(4-Azidobenzoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline. Grades: 98%. CAS No. 86329-06-8. Molecular formula: C21H22N8O3. Mole weight: 434.45. | |
| CP-601927 | CP-601927 is a CNS-penetrant, high affinity, and selective nicotinic acetylcholine receptor (nAChR) agonist. Uses: Nachr agonist. Synonyms: CP-601927; CP 601927; CP601927; CP-601,927; UNII-VI5LR1EU47; 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7-(trifluoromethyl)-, (1R,5S)-. Grades: ≥98%. CAS No. 357425-02-6. Molecular formula: C12H12F3N. Mole weight: 227.09. | |
| CP-601932 | CP-601932 is a CNS-penetrant, high affinity, and selective α(4) β(2) nicotinic acetylcholine receptors partial agonist. Uses: Nachr agonist. Synonyms: CP-601932; CP 601932; CP601932; CP-601,927; UNII-VI5LR1EU47; 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7-(trifluoromethyl)-, (1R,5S)-. Grades: ≥98%. CAS No. 357425-68-4. Molecular formula: C12H12F3N. Mole weight: 227.23. | |
| CP 615003 mesylate | CP 615003 mesylate is a potent and selective GABAA receptor partial agonist potentially useful in treating generalized anxiety disorder. Uses: Potential treatment of anxiety. Synonyms: CP 615003 mesylate; CP615003 mesylate; CP-615003 mesylate; N-(3-fluoro-4-(2-(propylamino)ethoxy)phenyl)-4,5,6,7-tetrahydro-4-oxo-1H-indole-3-carboxamide mesylate. Grades: 99%. CAS No. 1259477-42-3. Molecular formula: C20H24FN3O3.CH4O3S. Mole weight: 469.53. | |
| CP 6232 | CP 6232 is a new anti-pseudomonal cephalosporin as a cell wall inhibitor. It was developed by Meiji Seika Pharma. Research for the treatment of bacterial infections was discontinued. Uses: Bacterial infections. Synonyms: CP 6232; CP6232; CP-6232. 7-((2-Aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyiminoacetamido)-3-(N-(1,5-dihydroxy-4-pyridon-2-yl)methyl-N-methyl)aminomethyl-3-cephem-4-carboxylic acid. Grades: 98%. CAS No. 141562-38-1. Molecular formula: C24H27N7O10S2. Mole weight: 637.65. | |
| CP66,948 | CP66,948 is a histamine H2-receptor antagonist. It has gastric antisecretory activity and mucosal protective properties. Uses: Cp66,948 has gastric antisecretory activity and mucosal protective properties. Synonyms: CP66,948; CP 66,948; CP-66,948; CP 66948; 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole;CP-66,948CP-66,948;1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine. Grades: >98 %. CAS No. 101189-47-3. Molecular formula: C13H20N6S. Mole weight: 292.40. | |
| CP-673451 | CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity. Synonyms: CP-673451; CP673451; CP 673451; CP-673,451; CP 673451; CP 673,451. Grades: >98%. CAS No. 343787-29-1. Molecular formula: C24H27N5O2. Mole weight: 417.5. | |
| CP-690550A | This active molecular is a novel Janus Kinase 3 (JAK3) inhibitor. CP-690550A is an immunosuppressant for the treatment of rheumatoid arthritis, psoriasis, transplant rejection and other immune-mediated disorders. Uses: Immune-mediated disorders. Synonyms: CP-690550A; CP-690,550A; CP 690550A; CP690550A; Tofacitinib metabolite M2; UNII-Q7ZOK859UK; Tofacitinib metabolite M2; Q7ZOK859UK; CHEMBL1630791; 2-hydroxy-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone. Grades: 98%. CAS No. 1243290-37-0. Molecular formula: C15H21N5O2. Mole weight: 303.37. | |
| CP-724714 | CP-724714 is An orally bioavailable quinazoline with potential antineoplastic activity. CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth. HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers. Synonyms: CP-724714; CP 724714; CP724714. CAS No. 383432-38-0. Molecular formula: C27H27N5O3. Mole weight: 469.545. | |
| CP 775146 | CP 775146 is a high affinity PPARα agonist and show hypolipidemic activity in vivo. Synonyms: CP-775146; CP 775146; CP775146. 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid. Grades: ≥99% by HPLC. CAS No. 702680-17-9. Molecular formula: C26H33NO4. Mole weight: 423.54. | |
| CP-809101 | CP-809101 is a potent and selective 5-HT2C receptor agonist (pEC50=9.96). Uses: 5-ht2c receptor agonist. Synonyms: CP 809101 hydrochloride; CP809101 hydrochloride; CP-809101 hydrochloride; 2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine;hydrochloride. Grades: ≥98%. CAS No. 479683-64-2. Molecular formula: C15H17ClN4O. Mole weight: 304.77. | |
| CP-809101 hydrochloride | The hydrochloride salt form of CP-809101 which is a selective 5-HT2C receptor agonist which probably shows antipsychotic activity and restrains amphetamine-stimulated hyperactivity in rats. The result of preclinical trial has not been reported yet. Uses: The hydrochloride salt form of cp-809101 which is a selective 5-ht2c receptor agonist which probably shows antipsychotic activity and restrains amphetamine-stimulated hyperactivity in rats. Synonyms: CP-809101 hydrochloride; CP 809101 hydrochloride; CP809101 hydrochloride; CP-809101 (hydrochloride); 479683-64-2; 2-((3-Chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride; 2-[(3-Chlorobenzyl)oxy]-6-(piperazin-1-yl)pyrazine hydrochloride; CP809101 hydrochloride; C15H18Cl2N4O. Grades: 98%. CAS No. 1215721-40-6. Molecular formula: C15H18Cl2N4O. Mole weight: 341.24. | |
| CP-810123 | CP-810123 is a novel alpha 7 nAChR agonist with potential treatment for cognitive deficits associated with psychiatric or neurological conditions including schizophrenia and Alzheimer's disease. Uses: Alpha 7 nachr agonist. Synonyms: CP-810123; CP810123; CP 810123; UNII-E6G4550EC4; 4-(5-methyloxazolo(4,5-b)pyridin-2-yl)-1,4-Diazabicyclo(3.2.2)nonane. Grades: ≥98%. CAS No. 439608-12-5. Molecular formula: C14H18N4O. Mole weight: 258.32. | |
| CP-85958 | This active molecular is a selective LTD4 antagonist. CP-85958 may become a clinical candidates for the treatment of asthma in the future. Uses: Asthma. Synonyms: CP-85958; CP85958; CP 85958; UNII-CU98Q2IL7P; (+)-Cp 85958;3-(((3R,4R)-6-((5-fluoro-2-benzothiazolyl)methoxy)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-3-yl)methyl)-Benzoic acid. Grades: 98%. CAS No. 134002-60-1. Molecular formula: C25H20FNO5S. Mole weight: 465.50. | |
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