BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| JNJ 28871063 hydrochloride | The hydrochloride salt form of JNJ 28871063, which has been found to be a nonquinazoline Pan-ErbB kinase inhibitor and probably could restrain the growth of human tumor xenografts. Synonyms: JNJ28871063 hydrochloride; JNJ-28871063 hydrochloride; 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride; 5-Pyrimidinecarboxaldehyde, 4-amino-6-[[3-chloro-4-(phenylmethoxy)phenyl]amino]-, O-[2-(4-morpholinyl)ethyl]oxime, hydrochloride (1:1), [C(E)]-; JNJ 28871063; (E)-4-amino-6-((4-(benzyloxy)-3-chlorophenyl)amino)pyrimidine-5-carbaldehyde O-(2-morpholinoethyl) oxime hydrochloride. Grades: ≥97% by HPLC. CAS No. 944342-90-9. Molecular formula: C24H27ClN6O3.HCl. Mole weight: 519.42. |  |
| JNJ-31020028 | JNJ-31020028 is a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. JNJ-31020028 bound with high affinity (IC50 = 8.07, human) and was 100-fold selective versus human Y(1), Y(4), and Y(5) receptors. JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04) in functional assays. Synonyms: JNJ31020028; JNJ 31020028; JNJ-31020028. Grades: 98%. CAS No. 1094873-14-9. Molecular formula: C34H36FN5O2. Mole weight: 565.6. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active and fast-dissociating antagonist of dopamine D2 receptor with a moderate binding affinity to dopamine D2L receptor (Ki = 158 nM). It has the potential to treat schizophrenia and bipolar disorder. Synonyms: 3-Pyridazinamine, N-(1-((3,4-difluorophenyl)methyl)-4-piperidinyl)-6-(trifluoromethyl)-, hydrochloride (1:2); N-(1-(3,4-difluorobenzyl)piperidin-4-yl)-6-(trifluoromethyl)pyridazin-3-amine dihydrochloride; N-[1-(3,4-Difluorobenzyl)-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine dihydrochloride. Grades: ≥98%. CAS No. 2108806-02-4. Molecular formula: C17H19Cl2F5N4. Mole weight: 445.26. | |
| JNJ-38877605 | JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Synonyms: JNJ-38877605; JNJ 38877605; JNJ38877605. Grades: >98%. CAS No. 943540-75-8. Molecular formula: C19H13F2N7. Mole weight: 377.36. | |
| JNJ-38877618 | JNJ-38877618 is a potent and selective inhibitor of hepatocyte growth factor receptor (HGFR; MET) that exhibits inhibitory effects against solid tumors. Synonyms: OMO-1; HY-111050; 6-[Difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline. CAS No. 943540-74-7. Molecular formula: C20H12F2N6. Mole weight: 374.35. | |
| JNJ-39758979 dihydrochloride | JNJ-39758979 is a potent and selective histamine H4 antagonist (Ki = 12.5 nM) with >80-fold selectivity for H4 over other histamine receptors. It was shown to inhibit histamine-induced pruritus in healthy subjects. Synonyms: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1620648-30-7. Molecular formula: C11H19N5·2HCl. Mole weight: 294.22. | |
| JNJ-39933673 hemihydrate | TA-1887 is a selective Sodium Glucose Cotransporter 2 Inhibitor with pronounced antihyperglycemic effects in high-fat diet-fed KK (HF-KK) mice. It may be used for treatment of Type 2 Diabetes in the future. Uses: Type 2 diabetes. Synonyms: JNJ-39933673 hemihydrate; TA-1887 hemihydrate; JNJ 39933673 hemihydrate; TA 1887 hemihydrate; JNJ39933673 hemihydrate; TA1887 hemihydrate; (2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluoro-1H-indol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate;1003005-29-5(Free). Grades: 98%. CAS No. 1404307-42-1. Molecular formula: 2(C24H26FNO5).H2O. Mole weight: 872.95. | |
| JNJ-40355003 | JNJ-40355003 is a selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 can elevate the plasma levels of anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide in animal model. Synonyms: JNJ-40355003; JNJ 40355003; JNJ40355003; 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-1-Piperazinecarboxamide. Grades: 98%. CAS No. 1394894-41-7. Molecular formula: C23H23ClN4O2. Mole weight: 422.91. | |
| JNJ-41443532 | This active molecular is a CCR2 receptor antagonist which is applicated for the treatment of type-2 diabetes mellitus under the development of Janssen Research & Development. In 2010, Phase-I clinical trials in Type-2 diabetes mellitus was on-going. in Belgium and USA. Uses: Type-2 diabetes mellitus. Synonyms: JNJ-41443532; JNJ 41443532; JNJ41443532; JNJ-41443532 Free Base; N-(2-((1-(trans-4-hydroxy-4-(5-thiazolyl)cyclohexyl)-3-azetidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)Benzamide. Grades: 98%. CAS No. 1228650-83-6. Molecular formula: C22H25F3N4O3S. Mole weight: 482.52. | |
| JNJ-42041935 | JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacological tool, which can investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia. Synonyms: JNJ-42041935; JNJ 42041935; JNJ42041935. Grades: 98%. CAS No. 1193383-09-3. Molecular formula: C12H6ClF3N4O3. Mole weight: 346.65. | |
| JNJ-42153605 | JNJ-42153605 is a selective positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor (EC50 = 17 Nm) with an acceptable pharmacokinetic profile in rodent and nonrodent species. Synonyms: 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl(1,2,4)triazolo(4,3-a)pyridine; JNJ-42153605; JNJ 42153605; JNJ42153605. CAS No. 1254977-87-1. Molecular formula: C22H23F3N4. Mole weight: 400.44. | |
| JNJ4796 | JNJ4796 is an oral active influenza virus fusion inhibitor. Synonyms: EZ7; JNJ-4796; JNJ 4796. Grades: 98%. CAS No. 2241664-16-2. Molecular formula: C28H27N9O3. Mole weight: 537.6. | |
| JNJ 47965567 | JNJ 47965567 has been found to be a selective P2X7 antagonist and is brain penetrant. Synonyms: JNJ-47965567; JNJ 47965567; JNJ47965567. 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1428327-31-4. Molecular formula: C28H32N4O2S. Mole weight: 488.64. | |
| JNJ 5207787 | JNJ 5207787 has been found to be a selective NPY Y2 antagonist (IC50 = 0.1 μM). Synonyms: JNJ-5207787; JNJ 5207787; JNJ5207787; (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide; trans-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]acrylamide. Grades: ≥98% by HPLC. CAS No. 683746-68-1. Molecular formula: C32H38N4O2. Mole weight: 510.67. | |
| JNJ 5207852 dihydrochloride | Cas No. 398473-34-2. | |
| JNJ 55511118 | JNJ 55511118 has been found to be an AMPA receptor modulator and could probably be used as an anticonvulsant. Synonyms: JNJ-55511118; JNJ 55511118; JNJ55511118; 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥98% by HPLC. CAS No. 2036081-86-2. Molecular formula: C14H8ClF3N2O2. Mole weight: 328.67. | |
| JNJ-632 | JNJ-632 is a modulator of hepatitis B virus (HBV) capsid assembly. It induces the formation of morphologically intact viral capsids, as demonstrated by size exclusion chromatography and electron microscopy studies. Uses: Antiviral agents. Synonyms: N-(4-fluoro-3-methylphenyl)-3-[[(3S)-oxolan-3-yl]sulfamoyl]benzamide. Grades: ≥98%. CAS No. 1572510-42-9. Molecular formula: C18H19FN2O4S. Mole weight: 378.42. | |
| JNJ-7706621 | JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro. In human cancer cells, treatment with JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation. At low concentrations, JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Synonyms: JNJ-7706621; JNJ-7706621; JNJ-7706621. CAS No. 443797-96-4. Molecular formula: C15H12F2N6O3S. Mole weight: 394.36. | |
| JNJ-7777120 | JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors. Synonyms: JNJ7777120; JNJ-7777120; JNJ 7777120. Grades: >98%. CAS No. 459168-41-3. Molecular formula: C14H16ClN3O. Mole weight: 277.75. | |
| JNJ DGAT2-A | JNJ DGAT2-A has been found to be a DGAT2 inhibitor (IC50 = 140 nM) and also a useful intermediate. Synonyms: JNJ-DGAT2-A; JNJDGAT2A; JNJ DGAT2 A; 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2- (pyridin-2-yl) ethyl]amino]-1, 3-thiazol-5- (4H) ylidene]methyl]phenoxy]benzonitrile. Grades: ≥98% by HPLC. CAS No. 1962931-71-0. Molecular formula: C24H16BrFN4O2S. Mole weight: 523.38. | |
| JNK-IN-7 | Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM. Synonyms: JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7; JNK-IN-7. Grades: >98%. CAS No. 1408064-71-0. Molecular formula: C28H27N7O2. Mole weight: 493.56. | |
| ?JNK Inhibitor II, negative control | ?JNK Inhibitor II, negative control is a methylated analog of SP 600125, a cell-permeable and reversible inhibitor of JNK1/2/3. It exhibits lower activity against JNK isoforms. Synonyms: SP 600125, negative control; N1-Methyl-1,9-pyrazoloanthrone. Grades: ≥97%. CAS No. 54642-23-8. Molecular formula: C15H10N2O. Mole weight: 234.3. | |
| JNK Inhibitor IX | JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. Synonyms: TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671, SC 202671, SC202671. Grades: >98%. CAS No. 312917-14-9. Molecular formula: C20H16N2OS. Mole weight: 332.42. | |
| JP104 | JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. JP104 is in the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-undecynecarbamate. Grades: ≥98%. CAS No. 887264-45-1. Molecular formula: C25H30N2O3. Mole weight: 406.5. | |
| JP 1302 dihydrochloride | The hydrochloride salt form of JP 1302, which has been found to be an α2-adrenoceptor blocker and could probably be used for prevention or treatment of nephropathy. Synonyms: JP 1302 dihydrochloride; JP1302 dihydrochloride; JP-1302 dihydrochloride; N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride; N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine Hydrochloride (1:2). Grades: ≥99% by HPLC. CAS No. 1259314-65-2. Molecular formula: C24H24N4.2HCl. Mole weight: 441.40. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor. JP83 is in the carbamate class with an IC50 of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-hexylphenylcarbamate. Grades: ≥98%. CAS No. 887264-44-0. Molecular formula: C26H28N2O3. Mole weight: 416.5. | |
| JPC-211 | JPC-211 is a selective dopamine D3 receptor agonist. Uses: Dopamine antagonists. Synonyms: JPC-211; JPC 211; JPC211; 234757-41-6(maleate); PNU-99194A free base;2,3-dihydro-5,6-dimethoxy-N,N-dipropyl- 1H-Inden-2-amine. Grades: 98%. CAS No. 82668-33-5. Molecular formula: C17H27NO2. Mole weight: 277.41. | |
| JQEZ5 | JQEZ5 is a potent and selective inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). JQEZ5 is developed for the treatment of some cancers in which EZH2 is overexpressed, such as non-small cell lung carcinoma (NSCLC). Synonyms: N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide. Grades: ≥98%. CAS No. 1913252-04-6. Molecular formula: C30H38N8O2. Mole weight: 542.68. | |
| JSH-23 | JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. JSH-23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear translocation of p65/p50 subunit was inhibited by JSH-23 treatment in the sciatic nerve. The treatment also lowered the elevated IL-6, TNF-α, cyclo-oxygenase (COX-2) and inducible nitric oxide synthase (iNOS) levels/expression, indicating reduction in the inflammatory damage of the sciatic nerve. Apart from these effects, JSH-23 also increased Nrf2 and hemeoxygenase-1 (HO-1) levels which could imply its potential in increasing the strength of antioxidant defence. Synonyms: JSH-23; JSH 23; JSH23. Grades: 0.98. CAS No. 749886-87-1. Molecular formula: C16H20N2. Mole weight: 240.35. | |
| JT010 | JT010 is a TRPA1 channel activator (EC50 = 0.65 nM) with potent selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM). It activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Synonyms: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide. Grades: ≥98% by HPLC. CAS No. 917562-33-5. Molecular formula: C16H19ClN2O3S. Mole weight: 354.85. | |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and &mu. It is an opioid analgesic drug used in scientific research. Synonyms: JTC-801; JTC 801; JTC801. Grades: >98%. CAS No. 244218-51-7. Molecular formula: C26H25N3O2.HCl. Mole weight: 447.96. | |
| JTE522 | JTE522, a selective COX-2 inhibitor, can induce apoptosis and inhibit cell proliferation in human endometrial cancer cell line RL95-2 cells and to explore the molecular mechanisms. Synonyms: 4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide; 4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide; JTE 522; JTE-522. CAS No. 180200-68-4. Molecular formula: C16H19FN2O3S. Mole weight: 338.4. | |
| JW55 | JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively. Synonyms: JW55; JW-55; JW 55. CAS No. 664993-53-7. Molecular formula: C25H26N2O5. Mole weight: 434.492. | |
| JW 67 | JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human colorectal cancer cells. Synonyms: JW 67; JW 67; JW 67; Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione. Grades: ≥97% by HPLC. CAS No. 442644-28-2. Molecular formula: C21H18N2O6. Mole weight: 394.38. | |
| JW74 | JW74 is a tankyrase-specific inhibitor. JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. At the molecular level, JW74 induces stabilization of AXIN2, a key component of the β-catenin destruction complex, resulting in reduced levels of nuclear β-catenin. At the functional level, JW74 induces reduced cell growth in all three tested cell lines, in part due to a delay in cell cycle progression and in part due to an induction of caspase-3-mediated apoptosis. Furthermore, JW74 induces differentiation in U2OS cells, which under standard conditions are resistant to osteogenic differentiation. JW74 also enhances differentiation of OS cell lines, which do not harbor a differentiation block. Synonyms: JW74; JW-74; JW 74. Grades: 0.98. CAS No. 863405-60-1. Molecular formula: C24H20N6O2S. Mole weight: 456.5196. | |
| JX 401 | JX 401, cell-permeable piperidinamide compound, is a reversible and highly potent inhibitor of p38α isoform MAP kinase containing a 4-benzylpiperidine motif. Its IC50 value is 32 nM and displays no activity on the p38γ isoform. It effectively blocks the differentiation of L8 myoblasts to myotubes in a reversible manner and blocks the differentiation of myoblasts and myotubes in mammalian cells in culture. It is not a competitive inhibitor with respect to either ATP or substrate. It is hyperactive in inflammatory diseases and may reverse inflammation. Synonyms: JX-401; JX 401; JX401; 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine; [2-Methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-methanone; N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine. Grades: ≥98% by HPLC. CAS No. 349087-34-9. Molecular formula: C21H25NO2S. Mole weight: 355.49. | |
| JYL1421 | JYL1421 is a TRPV1 receptor antagonist. JYL1421 concentration-dependently (0.1-2 mM) inhibited capsaicin-evoked substance P, calcitonin gene-related peptide and somatostatin release from isolated tracheae. It also concentration-dependently decreased capsaicin-induced Ca(2+) accumulation in cultured trigeminal ganglion cells. Synonyms: 3-[ (4-Tert-butylphenyl) methyl]-1-[ (3-fluoro-4-methanesulfonamidophenyl) methyl]thiourea. Grades: ≥95%. CAS No. 401907-26-4. Molecular formula: C20H26FN3O2S2. Mole weight: 423.6. | |
| JZL195 | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
| K 01-162 | K 01-162 binds and destabilizes AβO (β-amyloid( EC50= 0.080 mM; IC50= 80 nM), can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms. Uses: Stabilizes hydrophobic core i of aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. in vivo. Synonyms: 7-bromo-N,N-dimethyl-9H-fluoren-2-amine; 9H-Fluoren-2-aMine, 7-broMo-N,N-diMethyl-. Grades: ≥98%. CAS No. 677746-25-7. Molecular formula: C15H14BrN. Mole weight: 288.19. | |
| K-115 | K-115, also called as Ripasudil or Glanatec, a selective ROCK inhibitor (IC50 =31 nM), is a promising emerging antiglaucoma drug, and was thus approved by the Japanese administrative authority in 2014. Synonyms: 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinolineGlanatecK-115; K 115; K115K115 compoundripasudil. CAS No. 223645-67-8. Molecular formula: C15H18FN3O2S. Mole weight: 323.39. | |
| K-11777 | K-11777 is a potent, irreversible cysteine protease inhibitor. Besides, K11777 is not only a substrate but also a mechanism-based inhibitor of CYP3A4. Synonyms: 4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide; APC-3316; APC3316; APC 3316; K-11777; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316. Grades: >98%. CAS No. 233277-99-1. Molecular formula: C32H38N4O4S. Mole weight: 574.74. | |
| K134 | K134 is a selective phosphodiesterase 3 (PDE3) inhibitor, and has been shown to exhibit more potent anti-platelet activity than cilostazol. In vivo studies have demonstrated the anti-thrombotic and anti-hyperplastic effects of K-134, and that these effects of K-134 are stronger than those of cilostazol. Synonyms: 1-cyclopropyl-1-[(1R,2R)-2-hydroxycyclohexyl]-3-[3-[(2-oxo-1H-quinolin-6-yl)oxy]propyl]urea; 6-(3-(3-cyclopropyl-3-(2-hydroxycyclohexyl)ureido)propoxy)-2(1H)-quinolinone; K 134 compound; K-134 compound; K134 compound; OPC 33509; OPC-33509; K-134. CAS No. 189362-06-9. Molecular formula: C22H29N3O4. Mole weight: 399.48. | |
| K 579 | K 579, a cyanopyrrolidine compound, is a potent and slow-binding dipeptidyl peptidase IV (DPP IV) inhibitor. It has been shown to reduce blood DPP IV activity and attenuate glucose excursion following glucose loading in Zucker fatty rats. It reduces plasma glucose concentration by augmenting GLP-1 and insulins response after glucose intake in rats in vivo. It is used as a long-acting hypoglycemic agent. Synonyms: K 579; K579; K-579; (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile; (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile; DPP IV Inhibitor IV. Grades: ≥99% by HPLC. CAS No. 440100-64-1. Molecular formula: C17H24N6O. Mole weight: 328.41. | |
| K-858 | K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Synonyms: K-858; K 858; K858. Grades: 98%. CAS No. 72926-24-0. Molecular formula: C13H15N3O2S. Mole weight: 277.34. | |
| Kaempferide | Kaempferide is an O-methylated flavonol. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. Uses: Antioxidant. Synonyms: 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; Flavone, 3,5,7-trihydroxy-4'-methoxy-; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 3,5,7-Trihydroxy-4'-methoxyflavone; 4'-Methoxykaempferol; 4'-Methylkaempferol; 4'-O-Methylkaempferol; 4'-O-Methylkaempherol; 5,7-Dihydroxy-4'-methoxyflavonol; Kaempferid; Kaempferol 4'-methyl ether; Kaempferol 4'-O-methyl ether; Kaempherol 4'-O-methyl ether; NSC 407294. Grades: >98%. CAS No. 491-54-3. Molecular formula: C16H12O6. Mole weight: 300.26. | |
| Kasugamycin hydrochloride hydrate | Kasugamycin, an aminoglycosidic antibiotic, inhibits protein synthesis by interacting with the 30S ribosomal subunit. The mechanism of inhibition of protein synthesis seems to be different from that of other aminoglycosides such as streptomycin, kanamycin. Synonyms: 2-amino-2-[(2R,3S,5S,6R)-5-amino-2-methyl-6-[(2S,3S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyoxan-3-yl]iminoacetic acid;hydrate;hydrochloride UNII-5A9BN7V7QL 5A9BN7V7QL SCHEMBL69506 200132-83-8. CAS No. 200132-83-8. Molecular formula: C14H28ClN3O10. Mole weight: 433.84. | |
| KB3022 | A cyclooxygenase (COX) inhibitor. Synonyms: ethyl 2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetate; 1H-Pyrrole-1-acetic acid, 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-, ethyl ester; ethyl 2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)pyrrol-1-ylacetate; KB 3022; KB-3022; KBT-3022. CAS No. 101001-34-7. Molecular formula: C25H24N2O4S. Mole weight: 448.53. | |
| KB-R7943 mesylate | KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 μM). Synonyms: KB-R7943; KB R7943; KB-R 7943; KB-R7943 mesylate. Grades: 98%. CAS No. 182004-65-5. Molecular formula: C17H21N3O6S2. Mole weight: 427.49. | |
| KB SRC 4 | KB SRC 4 is a cell-permeable, potent and highly selective c-Src inhibitor with Kd value of 86 nM and Ki value of 44 nM, which is a key signaling kinase in cancer. It displays no inhibition on c-Abl up to 125 μM and is selective between Src family members. It inhibits cell growth in 4T1 mammary carcinoma tumor cells. It has antitumor activity and may be a promising therapeutic potential in the treatment of cancers. Synonyms: 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 1380088-03-8. Molecular formula: C32H23ClN8. Mole weight: 555.03. | |
| KC 12291 hydrochloride | KC 12291 hydrochloride is the hydrochloride salt of KC 12291, which is an orally active atypical inhibitor of voltage-gated sodium channels in ischemia. It inhibits sustained sodium currents and delays myocardial sodium overload, thus prevents diastolic contracture in isolated atria in vitro. It shows bradycardic, cardioprotective and anti-ischemic activity in vivo. Synonyms: KC 12291 hydrochloride; KC12291 hydrochloride; KC-12291 hydrochloride; 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride. Grades: ≥97% by HPLC. CAS No. 181936-98-1. Molecular formula: C22H28N3O3SCl. Mole weight: 449.99. | |
| KC7F2 | KC7F2 is a selective HIF-1α transcription inhibitor with IC50 of 20 μM in a cell-based assay. Synonyms: KC7f2; 927822-86-4; UNII-94C2DMM81LN, N'- (disulfanediylbis (ethane-2, 1-diyl) ) bis (2, 5-dichlorobenzenesulfonamide) 2, 5-dichloro-N- [2- [2- [ (2, 5-dichlorophenyl) sulfonylamino] ethyldisulfanyl] ethyl] benzenesulfonamide. Grades: 98%. CAS No. 927822-86-4. Molecular formula: C16H16Cl4N2O4S4. Mole weight: 570.38. | |
| KD 5170 | KD 5170 is a mercaptoketone-based histone deacetylase (HDAC) inhibitor displaying antitumor activity in vitro and in vivo. It exhibits broad spectrum antitumor activity in vitro and in vivo. Synonyms: S- (2- (6- (4- (3- (Dimethylamino) propoxy) phenylsulfonamido) pyridin-3-yl) -2-oxoethyl) ethanethioate. Grades: ≥98%. CAS No. 940943-37-3. Molecular formula: C20H25N3O5S2. Mole weight: 451.6. | |
| KDM4D-IN-1 | A novel histone lysine demethylase 4D (KDM4D) inhibitor (IC50= 0.41±0.03 μM). Synonyms: KDM4D-IN-1; KDM4D IN 1. CAS No. 2098902-68-0. Molecular formula: C11H7N5O. Mole weight: 225.21. | |
| KDM5A-IN-1 | KDM5A-IN-1, a pyrrolidine amide compound, is an inhibitor histone demethylases. Synonyms: KDM5A-IN-1; KDM5A IN 1; KDM5AIN1; KDM5A inhibitor-1; KDM5A inhibitor 1; N-[(3R)-1-(5-propan-2-yl-1H-pyrazole-3-carbonyl)pyrrolidin-3-yl]cyclopropanecarboxamideKDM5A-IN-1. CAS No. 1905481-36-8. Molecular formula: C15H22N4O2. Mole weight: 290.36. | |
| KDM5-IN-1 | KDM5-IN-1 is a potent and selective KDM5 inhibitor with modest cell activity (PC9 H3K4Me3 EC50 = 5.2 μM). Synonyms: KDM5-IN-48; KDM5 IN 48; KDM5IN48; KDM5 inhibitor-48; KDM5 inhibitor 48; 5-(1-tert-butylpyrazol-4-yl)-7-oxo-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile. CAS No. 1628210-26-3. Molecular formula: C17H20N6O. Mole weight: 324.38. | |
| KDR-in-4 | A potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor (IC50= 7 nM). Synonyms: 3-[5-[2-[2-methoxyethyl(methyl)amino]ethoxy]-1H-indol-2-yl]-1H-quinolin-2-one. CAS No. 408502-06-7. Molecular formula: C23H25N3O3. Mole weight: 391.46. | |
| Kebuzone | Kebuzone is a non-steroidal anti-inflammatory drug. It also has analgesic, antipyretic, and platelet-inhibitory activities. Kebuzone is a cyclooxygenase inhibitor. It can block the synthesis of prostaglandins by inhibiting cyclooxygenase. Uses: Non-steroidal anti-inflammatory drug. Synonyms: 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(2-acetylethyl) pyrazolidine-3,5-dione; Chebutan; Chepirol; Chetazol; Chetazolidin; Chetil; Chetopir; Copirene; Ejor; Gammachetone; KPB; Ketanol; Ketason; Ketazon; Ketazone; Ketophenylbutazone; Pecnon; Phloguron; Recheton; Reuchetal; γ-Ketazone; γ-Ketophenylbutazone; γ-Oxophenylbutazone. Grades: 98%. CAS No. 853-34-9. Molecular formula: C19H18N2O3. Mole weight: 322.36. | |
| Ketotifen | Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators, used as self-medication for the temporary relief of itching of the eye due to allergic conjunctivitis (ophthalmic). Uses: Histamine receptor antagonists. Synonyms: 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piper; 4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one. Grades: ≥98%. CAS No. 34580-13-7. Molecular formula: C19H19NOS. Mole weight: 309.426. | |
| Kevetrin hydrochloride | Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity. Uses: Inhibiting cancer cell growth and causing tumor cell apoptosis. Synonyms: UNII-NL6L2371DP; thioureidobutyronitrile; 3-cyanopropyl carbamimidothioate;hydrochloride; Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride. Grades: ≥95%. CAS No. 66592-89-0. Molecular formula: C5H10ClN3S. Mole weight: 179.66. | |
| KF21213 | KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. The Ki values of KF21213 were 3.0 nM for the adenosine A2A receptors and >10,000 nM for the adenosine A1 receptors. KF21213 showed a slightly higher affinity for the A2A receptors and a much lower affinity for the A1 receptors than KF18446 (Ki= 5.9 nM for A2A receptors and Ki= 1600 nM for the A1 receptors). Synonyms: 8-[2-(4-methoxy-2,3-dimethylphenyl)ethenyl]-1,3,7-trimethylpurine-2,6-dione; 8-(2,3-dimethyl-4-methoxystyryl)-1,3,7-trimethylxanthine; KF 21213; KF-21213; KF21213. CAS No. 155271-17-3. Molecular formula: C19H22N4O3. Mole weight: 354.4. | |
| KF-25706 | KF25706 is derivative of radicicol that binds to the Hsp90 chaperone machinery with IC50 of 39 nM. Synonyms: KF-25706; KF 25706; KF25706; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-oxime, (1aS,?2Z,?4E,?14R,?15aS)?-,UCS1006-S15. Grades: >98%. CAS No. 184537-25-5. Molecular formula: C18H18ClNO6. Mole weight: 379.79. | |
| KF-55823 | KF55823 is a derivative of radicicol that binds to the Hsp90 chaperone machinery. Synonyms: KF-55823; KF 55823; KF55823. Grades: >98%. CAS No. 452083-20-4. Molecular formula: C24H27ClN2O7. Mole weight: 490.94. | |
| KF-58333 | KF58333 is a novel derivative of radicicol that binds to the Hsp90 chaperone machinery, depletes p210Bcr-Abl and Raf-1 proteins followed by induction of erythroid differentiation and G1 phase accumulation, and induces apoptosis in human CML cells. Synonyms: KF-58333; KF 58333; KF58333; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-[O-[2-(2-oxo-1-pyrrolidinyl)?ethyl]?oxime]?, (1aR,?2Z,?4E,?6E,?14R,?15aR)?- (9CI). Grades: >98%. CAS No. 308244-21-5. Molecular formula: C24H27ClN2O7. Mole weight: 490.93. | |
| KFM19 | KFM19 is a selective adenosine A1-antagonist with good bioavailability (IC50= 50 nM). Synonyms: 8-(3-oxocyclopentyl)-1,3-dipropyl-7H-purine-2,6-dione; ((S)-(-)-8-(3-oxocyclopentyl)-1,3-dipropyl-7H-purine-2,6-dione) 1H-Purine-2,6-dione, 3,7-dihydro-8-(3-oxocyclopentyl)-1,3-dipropyl-; BIIP 20; BIIP-20; KFM 19; KFM-19; BIIP20; KFM19. CAS No. 133058-72-7. Molecular formula: C16H22N4O3. Mole weight: 318.37. | |
| KG 5 | KG 5 is a B-Raf allosteric and PDGFRβ inhibitor. It inhibits FLT3, KIT and c-Raf. It arrests cells in prometaphase and inhibits growth of renal and pancreatic tumors in mice. It also inhibits angiogenesis in a mouse angiogenesis model and disrupts blood vessel formation in zebrafish embryos. It is orally available. Synonyms: KG-5; KG 5; KG5; 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine; 2-Methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 877874-85-6. Molecular formula: C20H16F3N7OS. Mole weight: 459.45. | |
| KH-CB19 | KH-CB19, a CLK1/CLK4 inhibitor, has been found to probably restrain the phosphorylation of serine- and arginine-rich (SR) proteins. IC50: 20 nM for CLK1. Uses: Kh-cb19 is a clk1/clk4 inhibitor that has been found to probably restrain the phosphorylation of serine- and arginine-rich (sr) proteins. Synonyms: KH-CB19; KH CB19; KHCB19. Ethyl 3-[(E)-2-Amino-1-Cyanoethenyl]-6,7-Dichloro-1-Methyl-1h-Indole-2-Carboxylate; 2wu7; GTPL8055; 3761AH. Grades: 98%. CAS No. 1354037-26-5. Molecular formula: C15H13Cl2N3O2. Mole weight: 338.19. | |
| Ki8751 | Ki8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM). Synonyms: Ki8751; Ki-8751; Ki 8751. Grades: 0.98. CAS No. 228559-41-9. Molecular formula: C24H18F3N3O4. Mole weight: 469.41. | |
| Kif15-IN-1 | Kif15-IN-1 is a potent Kif15 kinesin inhibitor, which inhibits cellular proliferation in tumor cell lines. Synonyms: KIF15-IN-1; KIF15IN-1; KIF15-IN1; KIF15IN1; KIF15 IN 1. Grades: >98%. CAS No. 672926-32-8. Molecular formula: C20H22N4O5S. Mole weight: 430.48. | |
| Kif15-IN-2 | Kif15-IN-2 is a potent Kif15 kinesin inhibitor, which inhibits cellular proliferation in tumor cell lines. Synonyms: KIF15-IN-2; KIF15IN-2; KIF15-IN2; KIF15IN2; KIF15 IN 2. Grades: >98%. CAS No. 672926-33-9. Molecular formula: C20H20N6O4S. Mole weight: 440.48. | |
| Kinesore | Kinesore is a cell-permeable kinesin-1 modulator. It inhibits kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptors, but activates kinesin-1's function of controlling microtubule dynamics in cells. Synonyms: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide. Grades: ≥98% by HPLC. CAS No. 363571-83-9. Molecular formula: C20H16Br2N4O4. Mole weight: 536.17. | |
Our database is helping our users find suppliers everyday.
