BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| HS-10296 | HS-10296 is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Synonyms: HS 10296; HS10296. CAS No. 1899921-05-1. Molecular formula: C30H35N7O2. Mole weight: 525.64. |  |
| HS-27 | HS-27 is a fluorescently linked Hsp90 inhibitor with diagnostic and therapeutic potential in triple-negative breast cancer. Grades: 98%. CAS No. 1562024-11-6. Molecular formula: C52H60N6O12S. Mole weight: 993.1. | |
| HSF1A | HSF1A is a cell-permeable human heat shock factor protein (HSP1) activator. Synonyms: 4-Ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide. Grades: 99%. CAS No. 1196723-93-9. Molecular formula: C21H19N3O2S2. Mole weight: 409.52. | |
| HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor that interferes with the formation of functional Hsp70-HOP-Hsp90 machinery, and it inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. Synonyms: HSP70-IN-1; HSP70 IN 1; 2-amino-N-[3-[2-(4-methylpiperazin-1-yl)-4-phenylmethoxypyrimidin-5-yl]sulfanylphenyl]acetamide; SCHEMBL1276103. CAS No. 1268273-90-0. Molecular formula: C24H28N6O2S. Mole weight: 464.58. | |
| Hsp990 | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grades: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39. | |
| HTH-01-015 | HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM). Synonyms: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. Grades: >98%. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.55. | |
| HTL26119 | HTL26119 is a glucagon-like peptide-1 receptor (GLP-1R) antagonist. Synonyms: HTL-26119; HTL 26119. Grades: ≥98% by HPLC. Molecular formula: C28H23Cl3N2O5. Mole weight: 573.85. | |
| HTMT dimaleate | HTMT dimaleate is a histamine H1 and H2 receptor agonist with 4x104 fold activity over histamine in H2-mediated effects in natural suppressor cells. HTMT dimaleate increases intracellular Ca2+ and IP3 in lymphocytes through a binding site except for H1, H2 or H3. Synonyms: 6-[2- (4-Imidazolyl) ethylamino]-N- (4-trifluoromethylphenyl) heptanecarboxamide dimaleate; Histamine trifluoromethyl toluidide. Grades: ≥99% by HPLC. CAS No. 195867-54-0. Molecular formula: C19H25F3N4O.2C4H4O4. Mole weight: 614.57. | |
| (±)-Huperzine A | Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. Uses: Cholinesterase inhibitors. Synonyms: Huperzine A. Grades: >98%. CAS No. 120786-18-7. Molecular formula: C15H18N2O. Mole weight: 242.32. | |
| HX 531 | HX 531 is a potent RXR antagonist (IC50 = 18 nM) that inhibits 9-cis retinoic acid-induced transactivation of RXR. HX 531 promotes the differentiation of white and brown pre-adipocyte to white adipocytes, and reduces triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice given a high fat diet. Synonyms: HX 531; HX-531; HX531. 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid. Grades: ≥98% by HPLC. CAS No. 188844-34-0. Molecular formula: C29H29N3O4. Mole weight: 483.56. | |
| HX-603 | HX-603 is a RXR agonist. Synonyms: 4-(7,7,10,10-tetramethyl-5-propyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid; HX-603; HX 603; HX603. Grades: >98%. CAS No. 259228-72-3. Molecular formula: C31H34N2O2. Mole weight: 466.625. | |
| HX 630 | HX 630 is a potent RXR agonist that acts as a retinoid synergist. HX 630 suppresses proliferation of vascular smooth muscle cells (VSMCs) in vivo and in vitro. It was shown to enhance ABCA1 mRNA expression and apoA-I-dependent cellular cholesterol release in differentiated THP-1 cells. Synonyms: HX 630; HX630; HX-630; 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid. Grades: ≥98% by HPLC. CAS No. 188844-52-2. Molecular formula: C28H27NO2S. Mole weight: 441.58. | |
| Hydrocortisone acetate | Hydrocortisone acetate, a derivative of hydrocortisone, is a corticosteroid compound that has a broad range of anti-inflammatory and immunosuppressive effects and thus widely used in therapy of skin wound. Uses: Hydrocortisone acetate could be an anti-inflammatory and immunosuppressive agent and thus widely used in therapy of skin wound. Synonyms: 21-Acetoxy-11β,17-dihydroxypregn-4-ene-3,20-dione; Cortisol Acetate; 17-Hydroxycorticosterone 21-Acetate; Abbocort; Bambicort; Colifoam; Lanacort; NSC 741; Pabracort; Sigmacort; Velopural; Wycort. Grades: 98%. CAS No. 50-03-3. Molecular formula: C23H32O6. Mole weight: 404.50. | |
| Hydroflumethiazide | Hydroflumethiazide is an anti-hypertensive and a diuretic drug. It is a sodium-chloride symporter inhibitor under the development of Shire and was approved by FDA in 1959. Uses: Anti-hypertensive and a diuretic drug. Synonyms: 3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; Bristab; Bristurin; Dihydroflumethiazide; Diucardin; Elodrine; Finuret; Flutizide; Glomerulin; Hidroalogen; Leodrine; Saluron; Vergonil. Grades: 97%. CAS No. 135-09-1. Molecular formula: C8H8F3N3O4S2. Mole weight: 331.29. | |
| Hydroxyfasudil | Hydroxyfasudil, formed through the metabolism action of Fasudil, could be useful in improving the symptoms of pulmonary hypertension for playing the role as an active Rho-kinase inhibitor and vasodilator. IC50: 0.12 uM and 0.17 uM for ROCK1 and ROCK2, res. Uses: Hydroxyfasudil could be useful in improving the symptoms of pulmonary hypertension for playing the role as an active rho-kinase inhibitor and vasodilator. Synonyms: 5-(1,4-Diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine;Hydroxyfasudil. Grades: >99 %. CAS No. 105628-72-6. Molecular formula: C14H17N3O3S. Mole weight: 307.37. | |
| Hydroxyzine | Hydroxyzine is a histamine H1-receptor antagonist. Uses: H1 receptor antagonist. anxiolytic. antihistaminic. Synonyms: 1- (p-Chloro-alpha-phenylbenzyl) -4- (2- ( (2-hydroxyethoxy) ethyl) piperazine; 1- (p-Chlorobenzhydryl) -4- (2- (2-hydroxyethoxy) ethyl) diethylenediamine; 1- (p-Chlorobenzhydryl) -4- (2- (2-hydroxyethoxy) ethyl) piperazine; 1- (p-Chlorodiphenylmethyl) -4- (2- (2-hydroxyethoxy) et. Grades: ≥98%. CAS No. 68-88-2. Molecular formula: C21H27ClN2O2. Mole weight: 374.91. | |
| Hydroxyzine pamoate | Hydroxyzine pamoate, a derivative of hydroxyzine, is a histamine H1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probably effective in the treatment of insomnia and withdrawal treatment. Uses: Hydroxyzine pamoate is a histamine h1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probably effective in the treatment of insomnia and withdrawal treatment. Synonyms: HYDROXYZINE PAMOATE;HYDROXYZINE PAMOATE SALT;hydroxyzine embonate;HYDROXYZINEPAMOATE,USP;1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine, pamoate;2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 2-[2-[4-[(4-chlorophe. Grades: 98%. CAS No. 10246-75-0. Molecular formula: C21H27ClN2O2.C23H16O6. Mole weight: 763.28. | |
| Hyperforin dicyclohexylammonium salt | Hyperforin is a principal ingredient of Hypericum perforatum (St. John's wort). Hyperforin activates TRPC6 channel to inhibit the reuptake of serotonin, suggesting its potential use as an antidepressant. It also exhibits antibacterial effects. Synonyms: Hyp-DCHA; Hyperforin-DCHA; Hyperforin DCHA. Grades: ≥97%. CAS No. 238074-03-8. Molecular formula: C35H52O4·C12H23N. Mole weight: 718.1. | |
| Hypotaurine | Hypotaurine is an endogenous inhibitory amino acid for glycine receptor (GlyR). It acts as an antioxidant and a protective agent under physiological conditions. Uses: Antioxidants. Synonyms: 2-aminoethanesulfinic acid. CAS No. 300-84-5. Molecular formula: C2H7NO2S. Mole weight: 109.15. | |
| HZ52 | HZ52 is a novel reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. HZ52 was shown to prevent carrageenan-induced pleurisy accompanied by reduced LTB(4) levels and protected mice (10 mg·kg?¹, i.p.) against PAF-induced shock. Synonyms: HZ-52; HZ 52; 2-[4-Chloro-6-(4-phenylanilino)pyrimidin-2-yl]sulfanyloctanoic acid. Grades: ≥98%. CAS No. 1077626-51-7. Molecular formula: C24H26ClN3O2S. Mole weight: 456. | |
| I-191 | I-191 is a potent antagonist of protease activated receptor 2 (PAR2). Synonyms: 4-[8-Tert-Butyl-6-(4-Fluorophenyl)Imidazo[1,2-B]Pyridazine-2-Carbonyl]-3,3-Dimethylpiperazin-2-One; PAR2 Antagonist I-191; SCHEMBL16598387; GTPL10268; BCP32684. Grades: 98%. CAS No. 1690172-25-8. Molecular formula: C23H26FN5O2. Mole weight: 423.5. | |
| I2906 | Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). Synonyms: I 2906; I-2906. Grades:>98%. CAS No. 331963-29-2. Molecular formula: C25H37N3O4. Mole weight: 443.58. | |
| IACS-8779 | IACS-8779 is a highly potent agonist of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. IACS-8779 shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma when compared to one of the clinical benchmark compounds. Synonyms: SCHEMBL23046679; 2243079-26-5; AKOS040733407. Grades: >98%. CAS No. 2243079-26-5. Molecular formula: C21H25N9O10P2S2. Mole weight: 689.56. | |
| IACS-8803 | IACS-8803 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. Compared to one of the clinical benchmark compounds, it shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma. Synonyms: CHEMBL4596454; SCHEMBL22930678; SCHEMBL23710564; 2095690-70-1; AKOS040733408. Grades: >98%. CAS No. 2095690-70-1. Molecular formula: C20H23FN10O9P2S2. Mole weight: 692.53. | |
| Iberiotoxin trifluoroacetate salt | Iberiotoxin is a 37-amino acid peptide toxin purified from the scorpion Buthus tamulus. It acts as a blocker of high conductance Ca(2+)-activated K+ channels at nanomolar concentrations. Grades: ≥95%. CAS No. 182897-30-9. Mole weight: 4230.9. | |
| Ibipinabant | Ibipinabant is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively. Uses: Cannabinoid receptor cb1 antagonists. Synonyms: BMS-646256; BMS646256; BMS 646256; SLV-319; SLV 319; SLV319; JD-5001; JD 5001; JD5001; Ibipinabant.3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4S-phenyl-1H-pyrazole-1-carboximidamide. Grades: ≥98%. CAS No. 464213-10-3. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.40. | |
| Ibotenic acid | Ibotenic acid is a neuroexcitatory amino acid originally isolated from amanita species. It is used as a non-selective NMDA and metabotropic glutamate receptor agonist. It is a neurotoxin and is often used to induce brain lesions in animals. It has been used to perform surgery in adult male zebra finches to study reversing reinforcement-induced vocal changes. Synonyms: (+/-)-Ibotenic acid; DL-Ibotenic acid. Grades: ≥98% by HPLC. CAS No. 2552-55-8. Molecular formula: C5H6N2O4. Mole weight: 158.11. | |
| I-BRD9 | I-BRD9, as a selective cell active chemical probe for BRD9 (pIC50 = 7.3), it exhibits 200-fold selectivity for bromodomain containing protein 9 over the highly homologous BRD7 bromodomain, >70-fold selectivity for BRD9 over a panel of 34 other bromodomain. Synonyms: N'-(1,1-dioxothian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamideI-BRD9; I-BRD-9; I-BRD 9N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamideG. CAS No. 1714146-59-4. Molecular formula: C22H22F3N3O3S2. Mole weight: 497.55. | |
| Ibufenac | Ibufenac is an analog of ibuprofen, and also acts as a COX inhibitor. Ibufenac can be used as an analgesic and anti-inflammatory agent but exhibits hepatotoxicity. Synonyms: Dytransin; Ibunac; 4-Isobutylphenylacetic acid; 2-[4-(2-methylpropyl)phenyl]acetic acid; NSC 99976. Grades: ≥95%. CAS No. 1553-60-2. Molecular formula: C12H16O2. Mole weight: 192.3. | |
| IC-87114 | IC-87114 is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 μM. Synonyms: IC87114; IC-87114; IC 87114. CAS No. 371242-69-2. Molecular formula: C22H19N7O. Mole weight: 397.442. | |
| IC87201 | IC87201, an efficient inhibitor of PSD95-nNOS protein-protein interactions, was found by screening and shown to disrupt the nNOS/PSD-95 interaction in an in vitro assay. Synonyms: 2-[(2H-benzotriazol-5-ylamino)methyl]-4,6-dichlorophenol 2-((1H-benzo(d)(1,2,3)triazol-5-ylamino)methyl)-4,6-dichlorophenol IC 87201 IC-87201 IC87201. CAS No. 866927-10-8. Molecular formula: C13H10Cl2N4O. Mole weight: 309.15. | |
| ICA-121431 | ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant sodium channels like human Nav1.5 or Nav1.7 channels. Synonyms: ICA-121431; ICA 121431; ICA121431. 2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamideICA-121431; ICA 121431; ICA121431. CAS No. 313254-51-2. Molecular formula: C23H19N3O3S2. Mole weight: 449.54. | |
| ICA-27243 | ICA-27243 is a selective, effective and orally active KCNQ2/Q3 potassium channel opener with EC50 of 0.38 μM. Synonyms: Benzamide, N-(6-Chloro-3-Pyridinyl)-3,4-Difluoro-. Grades: 98%. CAS No. 325457-89-4. Molecular formula: C12H7ClF2N2O. Mole weight: 268.64. | |
| I-CBP112 hydrochloride | I-CBP112 is a selective inhibitor of CBP and EP300 bromodomain (Kds = 0.142 and 0.625 μM, respectively). CBP and EP300 are histone acetyltransferase (HAT) enzymes that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. Synonyms: 1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one hydrochloride. Grades: ≥90%. CAS No. 2147701-33-3. Molecular formula: C27H36N2O5·HCl. Mole weight: 505.1. | |
| ICI 118551 hydrochloride | ICI 118551 hydrochloride is a highly selective β2 adrenergic antagonist (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively), inhibited cAMP accumulation by 50% (IC50 = 1.5 microM and 1.7 microM, respectively). Uses: A highly selective β2 adrenergic receptor antagonist. Synonyms: ICI 118551 hydrochloride; ICI118551 hydrochloride; ICI-118551 hydrochloride; (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride;(2R,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol;hydrochloride. Grades: ≥98%. CAS No. 72795-01-8. Molecular formula: C17H27NO2.HCl. Mole weight: 313.86. | |
| ICI141292 | ICI141292, also known as Epanolol, is a adrenergic β-antagonist with a greater affinity for β1- than β2-adrenoceptors, which is used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. Synonyms: N-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-2-(4-hydroxyphenyl)acetamide; epanolol; ICI 141,292; ICI 141292; ICI-141,292; N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-4-hydroxyphenylacetamide; Visacor. CAS No. 86880-51-5. Molecular formula: C20H23N3O4. Mole weight: 369.41. | |
| ICI 162,846 | ICI 162,846 is a potent histamine H2 receptor antagonist. Synonyms: ICI 162,846; ICI162,846; ICI-162,846; N-[1-(4-Carboxamidobutyl)-1H-pyrazol-3-yl)]-N'-(2,2,2-trifluoroethyl)guanidine; 3-[[Imino[(2,2,2-trifluoroethyl)amino]methyl]amino]-1H-pyrazole-1-pentanamide. CAS No. 84545-30-2. Molecular formula: C11H17F3N6O. Mole weight: 306.29. | |
| ICI-198615 | ICI-198615 is a novel, potent and selective peptide leukotriene antagonist. It may be useful for the the treatment of allergic diseases. Uses: Ici-198615 may be useful for the the treatment of allergic diseases. Synonyms: [1-[[2-Methoxy-4-[[ (phenylsulfonyl) amino]carbonyl]phenyl]methyl]-1H-indazol-6-yl]carbamic acid cyclopentyl ester;Cyclopentyl N-[1-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]indazol-6-yl]carbamate;ICI 198615; ICI-198615; ICI198615; ICI-198,615; ZM 198615; ZM-198615. Grades: >98 %. CAS No. 104448-53-5. Molecular formula: C28H28N4O6S. Mole weight: 548.61. | |
| ICI 199,441 hydrochloride | ICI 199,441 hydrochloride is the hydrochloride salt of ICI 199,441, which is a selective and highly potent κ agonist. It is 146-fold more active than U-50488 in vitro. It has a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. It has analgesic properties. Synonyms: ICI 199,441 hydrochloride; ICI199,441 hydrochloride; ICI-199,441 hydrochloride; 3,4-Dichloro-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]-benzeneacetamide Monohydrochloride; (S)-3,4-Dichloro-N-methyl-N-[1-phenyl-2-(1-pyrrolidinyl)ethyl]-benzeneacetamide Monohydrochloride; 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 115199-84-3. Molecular formula: C21H25Cl3N2O. Mole weight: 427.80. | |
| ICI 204,448 hydrochloride | ICI 204,448 hydrochloride is the hydrochloride salt of ICI 204,448, which is a peripherally acting κ opioid receptor agonist. It does not cross the blood-brain barrier. Synonyms: ICI 204,448 hydrochloride; ICI204,448 hydrochloride; ICI-204,448 hydrochloride; (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride; (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 121264-04-8. Molecular formula: C23H27Cl3N2O4. Mole weight: 501.84. | |
| ICI 211965 | ICI 211965 is a selective 5-lipoxygenase inhibitor and it may be useful in regulating production of those interleukins involved in joint cartilage destruction. Synonyms: ICI 211965; ICI-211965; ICI211965; 1-(3-(Naphth-2-ylmethoxy)phenyl)-1-(thiazol-2-yl)propyl methyl ether. Grades: 98%. CAS No. 129424-08-4. Molecular formula: C24H23NO2S. Mole weight: 389.52. | |
| ICI 216140 | ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50 = 2 nM in vitro). Grades: ≥95%. CAS No. 124001-41-8. Molecular formula: C45H65N13O8. Mole weight: 916.1. | |
| ICI 89406 | ICI 89406 is a selective β-adrenergic antagonist. It is a low efficacy partial agonist and does not affect resting cardiac parameters. Synonyms: ICI 89406; ICI89406; ICI-89406; N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-N'-phenylurea. Grades: ≥99% by HPLC. CAS No. 53671-71-9. Molecular formula: C19H22N4O3. Mole weight: 354.41. | |
| Icofungipen | Icofungipen, a cyclic β-amino acid, is the representative of a novel class of antifungals, active against Candida. Its in vivo efficacy indicates its potential for the oral treatment of yeast infections. Synonyms: (1R,2S)-2-amino-4-methylidenecyclopentane-1-carboxylic acid; Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI); Icofungipen; PLD 118; PLD118; PLD-118; BAY 10-8888; BAY 108888; BAY108888. Grades: 95%. CAS No. 198022-65-0. Molecular formula: C7H11NO2. Mole weight: 141.167. | |
| Icopezil maleate | The maleate salt form of Icopezil, a benzoxazol derivative, has been found to be an acetylcholinesterase inhibitor and was once studied for the treatment of Alzheimer's disease. It has already been discontinued by Pfizer. Synonyms: CP 118954-11; CP-118,954-11. UNII-1P15W0SPEN; Icopezil maleate [USAN]; Icopezil maleate (USAN); 145815-98-1; CHEMBL329012; CP 118954-11. Grades: 98%. CAS No. 145815-98-1. Molecular formula: C27H29N3O6. Mole weight: 491.54. | |
| Idarubicin Hydrochloride | Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Uses: Antibiotics, antineoplastic. Synonyms: (7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione Hydrochloride; 4-DMD HCl; 4-Demethoxydaunorubicin Hydrochloride; Idamycin; NSC 256439; Zavedos; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride (1:1). Grades: >98%. CAS No. 57852-57-0. Molecular formula: C26H27NO9.HCl. Mole weight: 533.95. | |
| IDF-11774 | IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. Study showed that IDF-11774 inhibited the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells under hypoxic conditions, suppressing angiogenesis of cancer cells by reducing the expression of HIF-1 target genes. Synonyms: EX-A3002; 2-[4-(1-adamantyl)phenoxy]-1-(4-methylpiperazin-1-yl)ethanone. CAS No. 1429054-28-3. Molecular formula: C23H32N2O2. Mole weight: 368.51. | |
| IDH305 | IDH305 is a potent, selective and brain penetrant inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively). It suppresses mutant IDH1-dependent 2-HG production and cell proliferation, and exhibits antitumor activity in preclinical studies. Synonyms: (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one. Grades: ≥98%. CAS No. 1628805-46-8. Molecular formula: C23H22F4N6O2. Mole weight: 490.45. | |
| IDRA-21 | IDRA-21, an analog of cyclothiazide, inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Synonyms: 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide; IDRA-21; IDRA 21; IDRA21. CAS No. 22503-72-6. Molecular formula: C8H9ClN2O2S. Mole weight: 232.68. | |
| Idrevloride | Idrevloride is an epithelial sodium channel (ENaC) inhibitor. Synonyms: 3, 5-diamino-6-chloro-N-{[4- (4-{2-[ (1-deoxy-D-glucitol-1-yl) (hexyl) amino]ethoxy}phenyl) butyl]carbamimidoyl} pyrazine-2-carboxamide; 3, 5-diamino-6-chloro-N- [N'- [4- [4- [2- [hexyl- [ (2S, 3R, 4R, 5R) -2, 3, 4, 5, 6-pentahydroxyhexyl] amino] ethoxy] phenyl] butyl] carbamimidoyl] pyrazine-2-carboxamide. CAS No. 1416973-63-1. Molecular formula: C30H49ClN8O7. Mole weight: 669.22. | |
| IEM 1460 | IEM 1460, an adamantane derivative, is a selective and voltage-dependent open-channel antagonist of AMPA receptors. It is Ca2+ permeable and lacks GluR2 subunits. So it may be used to discriminat between AMPA receptors of different subunit composition. It selectively blocks fast spiking interneuron but not mediums spiny projection neuron in mouse striatum. It is used as an anticonvulsant in vivo. Synonyms: IEM 1460; IEM1460; IEM-1460; N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide. Grades: ≥98% by HPLC. CAS No. 121034-89-7. Molecular formula: C19H38N2Br2. Mole weight: 454.33. | |
| IEM 1925 dihydrobromide | IEM 1925 dihydrobromide is the dihydrobromide salt of IEM 1925, which is a use- and voltage-dependent open-channel antagonist of AMPA receptors. It is selective between subtypes and blocks GluR2 subunit-lacking receptors more potently than GluR2-containing receptors and IEM 1754. It alleviates inflammatory pain in a rat model of peripheral inflammation. Synonyms: IEM 1925 dihydrobromide; IEM1925 dihydrobromide; IEM-1925 dihydrobromide; N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide. Grades: ≥98% by HPLC. CAS No. 258282-23-4. Molecular formula: C17H28N2.2HBr. Mole weight: 422.24. | |
| Ifenprodil | Ifenprodil is an NMDA receptor antagonist and acts at the polyamine site. It is also an α2 adrenergic receptor ligand. It is selective for σ2 ligand over σ1 sites. It is used as a neuroprotective agent and peripheral vasodilator. Uses: Excitatory amino acid antagonists. Synonyms: 4-[2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl]phenol; (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol; α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol; 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine); 2-(4-Benzylpiperidino)-1-(1-hydroxyphenyl)-1-propanol; RC 61-91. Grades: ≥99% by HPLC. CAS No. 23210-56-2. Molecular formula: C21H27NO2. Mole weight: 325.44. | |
| Ifetroban | Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials for the treatment of Asthma, Hepatorenal syndrome, Portal hypertension and Systemic scleroderma is on-going. Uses: Asthma; hepatorenal syndrome; portal hypertension; systemic scleroderma. Synonyms: Ifetroban; BMS 180291-02; BMS-180291; BMS180291; CHEMBL283100; BMS-180291;SCHEMBL9589119;3-[2-[[3-[4-(pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]propanoic acid. Grades: 98%. CAS No. 143443-90-7. Molecular formula: C25H32N2O5. Mole weight: 440.54. | |
| (+)-Igmesine hydrochloride | Igmesine is a selective σ1 receptor ligand (KD = 19.1 nM), with nearly no activity at σ2 receptors (IC50 > 1000 nM). It was developed by Pfizer. Igmesine inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner and IC50 value is approximately 100 nM. Igmesine can weekly inhibit brain 5-HT uptake in vitro. It exhibits neuroprotective and antidepressant effects. No developments were reported for the treatment of Cognition disorders, Diarrhoea and Major depressive disorder. Uses: Cognition disorders; diarrhoea; major depressive disorder. Synonyms: Igmesine HCl; CI-1019; JO-1784; CI 1019; JO 1784; CI1019; JO1784; (+)-(E)-N-(Cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)benzenemethanamine hydrochloride. Grades: 98%. CAS No. 130152-35-1. Molecular formula: C23H30ClN. Mole weight: 355.94. | |
| IHR 1 | IHR 1 is a potent and cell-membrane-impermeable Smo antagonist with IC50 value of 7.6 nM. It blocks hedgehog induced movement of Smo and blocks Smo accumulation into the primary cilium. It selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Synonyms: IHR-1; IHR 1; IHR1; N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]. Grades: ≥99% by HPLC. CAS No. 548779-60-8. Molecular formula: C20H12Cl4N2O2. Mole weight: 454.13. | |
| IHR-Cy3 | IHR-Cy3 is a potent fluorescent Smo antagonist with IC50 value of 100 nM. Synonyms: (2-[3-[1- (6-[[7-[[4-Chloro-3-[[4- (2, 5-dichlorobenzamido) phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1, 3-dihydro-3, 3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3, 3-dimethyl-5-sulfo-3H-indolium, inner salt. Grades: ≥95% by HPLC. Molecular formula: C58H63Cl3N6O10S2. Mole weight: 1174.64. | |
| IKK 16 | IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM). Synonyms: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; IKK-16; IKK 16; IKK16; IKK-16. Grades: >98%. CAS No. 873225-46-8. Molecular formula: C28H29N5OS. Mole weight: 483.63. | |
| IKK2 Inhibitor VI | IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grades: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3. | |
| IKK-2 inhibitor VIII | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grades: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9. | |
| IKK-3 Inhibitor | IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-&beta. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grades: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53. | |
| IKKε-IN-1 | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grades: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52. | |
| Ilimaquinone | Ilimaquinone is a marine sponge metabolite with antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. Ilimaquinone significantly enhanced TRAIL-induced apoptosis in HCT 116 cells and sensitized colon cancer cells to TRAIL-induced apoptosis through increased caspase-8, -3 activation, PARP cleavage, and DNA damage. Ilimaquinone also reduced the cell survival proteins Bcl2 and Bcl-xL, while strongly up-regulating death receptor (DR) 4 and DR5 expression. Synonyms: ilimaquinone; 71678-03-0; Illimaquinone; UNII-5U0WAN3N8Q5U0WAN3N8Q. Grades: ≥98%. CAS No. 71678-03-0. Molecular formula: C22H30O4. Mole weight: 358.5. | |
| Iloperidone hydrochloride | The hydrochloride salt form of Iloperidone which is a antagonist of both D2 and 5-HT2 receptor and has been commonly used against schizophrenia. IC50: 10-100 nm and <10nM for D2 and 5-HT2 receptors respectively (Ki). Uses: The hydrochloride salt form of iloperidone which is a antagonist of both d2 and 5-ht2 receptor and has been commonly used against schizophrenia. Synonyms: Iloperidone D3 Hydrochloride; CS-O-02812. Grades: 98%. CAS No. 1299470-39-5. Molecular formula: C24H28ClFN2O4. Mole weight: 465.96. | |
| Ilorasertib | Ilorasertib, also know as ABT-348, is a novel, potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials. ABT-348 has nanomolar potency (IC50) for inhibiting binding and cellular auto-phosphorylation of Aurora B (7 and 13 nM), C (1 and 13 nM) and A (120 and 189 nM). These results provide the rationale for clinical assessment of ABT-348 as a therapeutic agent in the treatment of cancer. Uses: Antineoplastic agents. Synonyms: ABT-348; Abbott 968660. Grades: 0.98. CAS No. 1227939-82-3. Molecular formula: C25H21FN6O2S. Mole weight: 488.541. | |
| Ilunocitinib | Ilunocitinib is a Janus kinase (JAK) inhibitor (veterinary use). Synonyms: {1-(cyclopropanesulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile; 2-(3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-1-(cyclopropylsulfonyl)azetidin-3-yl)acetonitrile; 3-Azetidineacetonitrile, 1-(cyclopropylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-. CAS No. 1187594-14-4. Molecular formula: C17H17N7O2S. Mole weight: 383.43. | |
| Imagabalin | Imagabalin acts as a ligand for the α2δ subunit of the voltage-dependent calcium channel, which has some selectivity for the α2δ1 subunit over α2δ2. It has anxiolytic, analgesic, hypnotic, and anticonvulsant-like activity. It was developed by Pfizer and is currently in phase III clinical trials for the treatment of generalized anxiety disorder. Uses: Imagabalin has anxiolytic, analgesic, hypnotic, and anticonvulsant-like activity. it is used for the treatment of generalized anxiety disorder. Synonyms: (3S,5R)-3-Amino-5-methyloctanoic acid;PD 0332334; PD0332334; PD-0332334; PD 332334; PD332334; PD-332334; PF-00195889; PF 00195889; PF00195889; PF-195889; PF 195889; PF195889; Imagabalin. Grades: 95%. CAS No. 610300-07-7. Molecular formula: C9H19NO2. Mole weight: 173.25. | |
| Imeglimin | Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic β-cells to uniquely target the key defects of type 2 diabetes. Synonyms: EMD 387008; EMD387008; EMD-387008. Grades: >98%. CAS No. 775351-65-0. Molecular formula: C6H13N5. Mole weight: 155.2. | |
| Imetit dihydrobromide | Imetit dihydrobromide is a potent and high affinity agonist at histamine H3 and H4 receptors (Ki = 0.3 and 2.7 nM, respectively). It induces an eosinophil shape change (EC50 = 25 nM). Synonyms: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide. Grades: ≥98% by HPLC. CAS No. 32385-58-3. Molecular formula: C6H10N4S.2HBr. Mole weight: 332.06. | |
| Imidazo[1,2-a]pyridine-2-carboxamide, 6-chloro-N-[6-(phenylmethoxy)-1H-benzimidazol-2-yl]- | An inhibitor of β-site amyloid precursor protein-cleaving enzyme (BACE). CAS No. 1254166-60-3. Molecular formula: C22H16ClN5O2. Mole weight: 417.85. | |
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