BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| KKL-10 | KKL-10 is a small-molecule ribosome rescue inhibitor with exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis in vitro and during ex vivo infection. Synonyms: KKL-10; KKL 10; KKL10. 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide; 5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide; 5-bromo-N-[5-(p-tolyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide. CAS No. 952849-76-2. Molecular formula: C14H10BrN3O2S. Mole weight: 364.22. |  |
| KKL-35 | KKL-35 is a trans-translation tagging reaction inhibitor (IC50= 0.9 μM), thereby inhibiting bacterial growth by blocking ribosome rescue. Synonyms: KKL-35; KKL 35; KKL35; 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide; F1374-0110; 4-chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide. CAS No. 865285-29-6. Molecular formula: C15H9ClFN3O2. Mole weight: 317.7. | |
| KM11060 | KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein. Synonyms: KM11060; KM-11060; KM 11060. Grades: 98%. CAS No. 774549-97-2. Molecular formula: C19H17Cl2N3O2S. Mole weight: 422.324. | |
| KN-62 | KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells. Uses: Enzyme inhibitors. Synonyms: KN-62; KN 62; KN62. Grades: >98%. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.84. | |
| KN-92 | KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. Synonyms: KN 92; KN92. Grades: >98%. CAS No. 176708-42-2. Molecular formula: C24H25ClN2O3S. Mole weight: 456.98. | |
| KN-92 hydrochloride | KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). At concentrations up to 25 μM, KN-92 is ineffective at inhibiting CaMKII or arresting cell growth of NIH 3T3 fibroblasts. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. Synonyms: KN 92 hydrochloride; KN92 hydrochloride. Grades: >98%. CAS No. 1431698-47-3. Molecular formula: C24H26Cl2N2O3S. Mole weight: 493.45. | |
| KN-92 phosphate | KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93. Synonyms: KN-92 phosphate; KN 92 phosphate; KN92 phosphate. Grades: >98%. CAS No. 1135280-28-2. Molecular formula: C24H28ClN2O7PS. Mole weight: 554.98. | |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. | |
| KN-93 hydrochloride | KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. KN-93 is commonly used for determining cellular functions. Synonyms: KN-93 HCl; N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride. Grades: ≥98%. CAS No. 1956426-56-4. Molecular formula: C26H29ClN2O4S·HCl. Mole weight: 537.5. | |
| KP136 | KP136, an antiallergic agent, remarkably inhibited the passive cutaneous anaphylaxis (PCA) with intravenous and oral dosing. KP-136 is an oral potent inhibitor on PCA, and it acts by blocking the release of chemical mediator(s) from mast cells. Synonyms: KP 136; KP136; KP-136; AL 136; AL136; AL-136; 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one; 8-hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one; KP 136; KP 136, potassium salt; KP 136, sodium salt; KP-136. CAS No. 76239-32-2. Molecular formula: C16H18N4O3. Mole weight: 314.34. | |
| KP496 | KP496, a novel dual antagonist of cysLT receptor and TP, is currently in clinical development as a dry powder inhaler. KP496 inhibited epithelial hypertrophy and increased mucus production in asthmatic animals. Synonyms: KP496; KP 496; KP-496; 2- [4- [ (4-chlorophenyl) sulfonylamino] butyl- [ [3- [ (4-propan-2-yl-1, 3-thiazol-2-yl) methoxy] phenyl] methyl] sulfamoyl] benzoic acid. CAS No. 217799-03-6. Molecular formula: C31H34ClN3O7S3. Mole weight: 692.27. | |
| KPM-2 | KPM-2 is an inhibitor of sirtuin-2 (SIRT2), an NAD-dependent protein deacetylase, which is thought to be involved in cancer progression and in neurodegeneration. It shows antiproliferative activity in cancer cells and inhibits neurite growth. KMP-2 is hopefully used for the treatment of cancer progression and neurodegenerative disorders. Uses: The potential treatment of cancer. Synonyms: KPM-2; KPM 2; KPM2. | |
| KRCA-0008 | Potent and selective dual ALK (anaplastic lymphoma kinase ) and ACK1 inhibitor (IC50 values 12 nM and 4 nM for ALK and Ack1, respectively) with good drug-like properties: good water-solubility with moderate plasma protein binding and low brain exposure. It has good liver microsomal stability and little to no CYP inhibition. KRCA0008 also shows promising pharmacokinetic parameters in both mice and rat (oral bioavailability=66-94.5%) and a modest tumor growth inhibition in vivo activity in H3122 human lung cancer bearing mice model comparable to Crizotinib without significant body weight change. Synonyms: KRCA-0008; KRCA 0008; KRCA0008. Grades: >98%. CAS No. 1472795-20-2. Molecular formula: C30H37ClN8O4. Mole weight: 609.12. | |
| KRH1636 | KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. It efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXCR4 coreceptor. It also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. It prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. It seems to be a promising agent for the treatment of HIV-1 infection. Uses: Krh1636 seems to be a promising agent for the treatment of hiv-1 infection. Synonyms: KRH-1636; KRH 1636; KRH1636. N-[(2S)-5-(diaminomethylideneamino)-1-[[(1S)-1-naphthalen-1-ylethyl]amino]-1-oxopentan-2-yl]-4-[[methyl(pyridin-2-yl)amino]methyl]benzamide;KRH-1636;N-((S)-5-guanidino-1-(((S)-1-(naphthalen-1-yl)ethyl)amino)-1-oxopentan-2-yl)-4-(((pyridin-2-ylmethyl)amino. Grades: 98%. CAS No. 568526-77-2. Molecular formula: C32H37N7O2. Mole weight: 551.70. | |
| KRH3955 | KRH3955 is a novel CXCR4 antagonist. It is an orally bioavailable compound. It inhibits SDF-1alpha-mediated chemotaxis and HIV-1 infection. Uses: Krh3955 inhibits sdf-1alpha-mediated chemotaxis and hiv-1 infection. Synonyms: KRH-3955; KRH 3955; KRH3955; KRH3955 Salt;N1-(4-((((1H-imidazol-2-yl)methyl)((1-methyl-1H-imidazol-2-yl)methyl)amino)methyl)benzyl)-N1-methyl-N4,N4-dipropylbutane-1,4-diamine tris((2R,3R)-2,3-dihydroxysuccinate);2,3-Dihydroxybutanedioic acid N-[[4-[[1H-imidazol-2-ylmethyl-[ (1-methylimidazol-2-yl) methyl]amino]methyl]phenyl]methyl]-N-methyl-N', N'-dipropylbutane-1, 4-diamine. Grades: >98%. CAS No. 1097732-62-1. Molecular formula: C40H63N7O18. Mole weight: 929.97. | |
| KRN4884 | KRN4884, a synthesized 3-pyridine derivative, shows a long-lasting antihypertensive effect based on its potent potassium channel-opening action. The long-lasting action may be due to a slow association/dissociation with/from the binding sites on vascular smooth muscle. Synonyms: 5-amino-N'-[2-(2-chlorophenyl)ethyl]-N-cyanopyridine-3-carboximidamide; 5-amino-N-(2-(2-chlorophenyl)ethyl)-N'-cyano-3-pyridinecarboxamidine; KRN 4884; KRN-4884; KRN4884. CAS No. 152802-84-1. Molecular formula: C15H14ClN5. Mole weight: 299.76. | |
| KRN633 | KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. Selectivity profiling with recombinant tyrosine kinases showed that KRN633 is highly selective for VEGFR-1, -2, and -3. KRN633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats. KRN633 also causes the regression of some well-established tumors and those that had regrown after the cessation of treatment. KRN633 was well tolerated and had no significant effects on body weight or the general health of the animals. KRN633 might be useful in the treatment of solid tumors and other diseases that depend on pathologic angiogenesis. Synonyms: KRN633; KRN-633; KRN 633. Grades: 0.98. CAS No. 286370-15-8. Molecular formula: C20H21ClN4O4. Mole weight: 416.86. | |
| KRP297 | KRP297, also called as L4 10198 or MK 767, is a Peroxisome proliferator-activated receptor (PPAR) alpha and gamma (PPARα and PPARγ) agonist. With potential to treat type 2 diabetes and dyslipidemia, KRP297 is able to decrease plasma glucose and insulin levels. Synonyms: 5-[ (2, 4-dioxo-1, 3-thiazolidin-5-yl) methyl]-2-methoxy-N-[[4- (trifluoromethyl) phenyl]methyl]benzamide; KCL1998001079; KRP 297; KRP-297; KRP297; L 410198; L-410198; L410198; MK 767; MK-767; MK767. Grades: >98%. CAS No. 213252-19-8. Molecular formula: C20H17F3N2O4S. Mole weight: 438.42. | |
| KU 0058948 hydrochloride | KU 0058948 hydrochloride is a potent poly ADP-ribose polymeras (PARP) inhibitor (IC50: 3.4 nM for PARP1). In vitro, KU-0058948 activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells and induces cell cycle arrest and apoptosis of primary myeloid leukemic cells thus KU-0058948 can be potentially used to treat myeloid leukemia and myelodysplastic syndromes. Uses: Potential treatment of myeloid leukemia and myelodysplastic syndromes. Synonyms: KU 0058948 hydrochloride; KU0058948 hydrochloride; KU-0058948 hydrochloride; 4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one hydrochloride. Grades: 99%. Molecular formula: C21H21FN4O2.HCl. Mole weight: 416.88. | |
| KU14R | KU14R is an antagonist of the atypical imidazoline binding site (putative I3 receptor) in isolated pancreatic islet beta cells. Synonyms: KU14R; KU-14R; KU 14R; 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazole KU 14R KU-14R KU14R. Grades: >99 %. CAS No. 189224-48-4. Molecular formula: C13H14N2O. Mole weight: 214.26. | |
| Kuwanon A | Kuwanon A, a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.), inhibits nitric oxide production (IC50 = 10.5 μM). Synonyms: 5,7-dihydroxy-2-(5-hydroxy-2,2-dimethylchromen-8-yl)-3-(3-methylbut-2-enyl)chromen-4-one. CAS No. 62949-77-3. Molecular formula: C25H24O6. Mole weight: 420.45. | |
| Kv1.3 Channel blocker 42 | Kv1.3 Channel blocker 42 is a selective potassium channel blocker of Kv1.3 current (IC50 < 50 nM). Kv1.3 channel blocker is promisingly used for the treatment of obesity and insulin resistance. Synonyms: Kv1.3 Channel blocker 42; 2108780-57-8; E98959; 1-(7-(3-(4-fluorophenyl)butoxy)-2,4-dimethyl-6-(2-(piperidin-1-yl)ethoxy)benzo[d]oxazol-5-yl)ethanone Hydrochloride. Grades: 99%. CAS No. 2108780-57-8. Molecular formula: C28H35FN2O4.HCl. Mole weight: 519.05. | |
| KW-2450 Tosylate salt | KW-2450 is insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) antagonist. KW-2450 can selectively bind to and inhibit the activities of IGF-1R and IR and this may lead to the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In Apr 2013, Phase-I/II for Breast cancer and Phase-I for Solid tumours were discontinued in USA. Uses: Breast cancer; solid tumours. Synonyms: KW-2450 Tosylate salt; KW 2450 Tosylate salt; KW2450 Tosylate salt; (E)-N-(2-(2-(1H-indazol-3-yl)vinyl)-5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)phenyl)-3-methylthiophene-2-carboxamide 4-methylbenzenesulfonate; 904899-25-8 (free base). Grades: 98%. CAS No. 1360433-93-7. Molecular formula: C35H37N5O6S2. Mole weight: 687.83. | |
| KW-2478 | KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: 2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide; KW 2478; KW2478; QY50S617NM; 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide; 819812-04-9 (free base); 2-[2-ethyl-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]carbonyl-3,5-bis(oxidanyl)phenyl]-~{N},~{N}-bis(2-methoxyethyl)ethanamide. Grades: >98%. CAS No. 819812-04-9. Molecular formula: C30H42N2O9. Mole weight: 574.66. | |
| KW-3902 | KW-3902 is a selective adenosine A1 receptor antagonist under the development of Kyowa Hakko and Merck & Co. It displays 890-fold selectivity for rat A1 receptors over A2A receptors. (Ki value for adenosine A1 is 0.19 nM; 170 nM for adenosine A2A ). KW-3902 exhibits diuretic and renal protective effects in rats. Clinical trials for the treatment of Acute heart failure, Cognition disorders and Hypertension was discontinued. Uses: Acute heart failure; cognition disorders; hypertension. Synonyms: 1,3-dipropyl-8-(3-noradamantyl)xanthine, 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione, KW-3902; KW 3902; KW3902; Rolofylline. Grades: 98%. CAS No. 136199-02-5. Molecular formula: C20H28N4O2. Mole weight: 356.46. | |
| KX1-004 | KX1-004 is an Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. KX1-004 has been used to protect the cochlea from hazardous noise. Synonyms: KX1-004; KX 1-004; KX1 004. Grades: 0.98. CAS No. 518058-84-9. Molecular formula: C16H13FN2O2. Mole weight: 284.29. | |
| KX2-391 dihydrochloride | KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Synonyms: KX2-391 dihydrochloride; 1038395-65-1; KX2-391 (dihydrochloride); Tirbanibulin (dihydrochloride); N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide;dihydrochloride. Grades: >98%. CAS No. 1038395-65-1. Molecular formula: C26H31Cl2N3O3. Mole weight: 504.45. | |
| KY1220 | KY1220 is a novel inhibitor of the Wnt/ß-catenin pathway, destabilizing both β-catenin and Ras via targeting the Wnt/β-catenin pathway (IC50= 2.1 μM in HEK293 reporter cells). Synonyms: KY1220; KY-1220; KY 1220; (5Z)-5-[[1-(4-nitrophenyl)pyrrol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-one. CAS No. 292168-79-7. Molecular formula: C14H10N4O3S. Mole weight: 314.32. | |
| Kynurenic acid | Kynurenic acid is a product of L-Tryptophan metabolism. It is a non-selective antagonist at NMDA and AMPA/kainate receptors. It could block kainic acid neurotoxicity. It has neruoactive activity having anticonvulsant and antiexcitotoxic properties. Uses: Excitatory amino acid antagonists. Synonyms: 4-Hydroxy-2-quinolinecarboxylic Acid; 4-Hydroxy-quinaldic Acid; 2-Carboxy-4-hydroxyquinoline; 4-Hydroxyquinaldic Acid; Quinurenic Acid; NSC 58973; 4-Hydroxyquinoline-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 492-27-3. Molecular formula: C10H7NO3. Mole weight: 189.17. | |
| L002 | L002 is an inhibitor of p300 histone acetyltransferase with IC50 value of 1.98 μM in vitro, which is a lysine acetyltransferase that catalyzes acetyl group attachment to lysine residues of a variety of proteins. It has weaker inhibitory effects against PCAF and GCN5. It acts as a critical coactivator of several oncogenic transcription factors involved in cancer cell survival and proliferation. It blocks acetylation of histones and p53, and reduces STAT3 phosphorylation in MDA-MB-468 xenografts, leukemia and lymphoma cell lines. It induces growth arrest and apoptosis in certain cancer cell lines and suppresses the growth of triple-negative breast cancer xenografts. Synonyms: 2,6-Dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione; NSC764414; NSC 764414; NSC-764414; L002; L 002; L-002. Grades: ≥98% by HPLC. CAS No. 321695-57-2. Molecular formula: C15H15NO5S. Mole weight: 321.35. | |
| L-152,804 | L-152,804 is a potent and selective orally available non-peptide neuropeptide Y Y5 receptor antagonist with Ki value of 26 nM for hY5. It displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. It is centrally active upon oral administration in vivo. It causes weight loss in diet-induced obese mice by inducing a potent reduction of food intake in rodents. Synonyms: L-152,804; L 152,804; L152,804; 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione; 9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone; 9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-one; L-152804; L152804. Grades: ≥99% by HPLC. CAS No. 6508-43-6. Molecular formula: C23H26O4. Mole weight: 366.46. | |
| L162441 | An antagonist of Angiotensin type 1 receptor. Synonyms: L162441; L 162441; L-162441; butyl N- [2- [4- [ [2-butyl-5-methyl-6- (pentanoylamino) imidazo [4, 5-b] pyridin-3-yl] methyl] phenyl] phenyl] sulfonylcarbamate. CAS No. 154512-46-6. Molecular formula: C34H43N5O5S. Mole weight: 633.8. | |
| L-165041 | L-165041 is a cell permeable PPARδ agonist which induces adipocyte differentiation in NIH-PPARδ cells. It displays more than 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. It reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. It also raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Uses: For research used only. Synonyms: L-165041; L165041; L 165041; L-165,041; L165,041; L 165,041. Grades: >98%. CAS No. 79558-09-1. Molecular formula: C22H26O7. Mole weight: 402.44. | |
| L-168,049 | L-168,049 is a non-peptidyl, very selective and potent human glucagon receptor (hGR) antagonist. It displays high affinity to human GR with IC50 value of 3.7 nM, but shows moderate affinity for murine and canine GRs. It inhibits glucagon-stimulated cAMP synthesis in murine liver membranes and in CHO cells expressing hGR. It is orally active in vivo. Synonyms: L-168,049; L 168,049; L168,049; 2-(4-Pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-propyloxyphenyl)pyrrole; 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine. Grades: ≥99% by HPLC. CAS No. 191034-25-0. Molecular formula: C24H20BrClN2O. Mole weight: 467.79. | |
| L-364,373 | L-364,373 is a KV7.1 (KCNQ1) channel activator. It decreases action potential duration (APD) in cardiac myocytes and activates the cardiac IKs current. Synonyms: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one; (R)-5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one; (3R)-5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one; R-L3; L 364373. Grades: ≥98% by HPLC. CAS No. 103342-82-1. Molecular formula: C25H20FN3O. Mole weight: 397.44. | |
| L-365,260 | L-365,260 is a nonpeptide cholecystokinin receptor 2 (CCK2/CCKB) antagonist. It selectively binds to gastrin and CCK2 sites to reduce basal acid secretion, and prevent gastrointestinal damage in models of peptic ulcer disease. Synonyms: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea. Grades: ≥99% by HPLC. CAS No. 118101-09-0. Molecular formula: C24H22N4O2. Mole weight: 398.46. | |
| L-651,582 | L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxidative phosphorylation in cancer cells and exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages. It may be used as a potential anti-cancer drug. It ameliorates experimental colitis by inhibiting nuclear factor-κB activation, colonic fibrosis and cytokine production. It has antimetastatic, antiangiogenic and antiproliferative activity in vivo. It displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro. It blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of calcium-release-activated calcium channel (CRAC) function, cell proliferation and maintenance of mitochondrial membrane potential. Synonyms: Carboxyamidotriazole; CAI; RFE-007; NSC-609974; L-651582; RFE007; NSC609974; L651582; 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 99519-84-3. Molecular formula: C17H12Cl3N5O2. Mole weight: 424.67. | |
| L-655,708 | L-655,708, an inverse agonist of α5 subunit involved in GABAA receptor, has been found to exhibit cognitive performance improvement in biological studies. Uses: L-655,708, is an inverse agonist of α5 subunit involved in gabaa receptor and has been found to exhibit cognitive performance improvement in biological studies. Synonyms: L-655708; L655708; L 655708; L-655,708; L655,708; L 655,708; FG-8094; FG 8094; FG8094; ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;L-655,708;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;11,12,1. Grades: >99 %. CAS No. 130477-52-0. Molecular formula: C18H19N3O4. Mole weight: 341.36. | |
| L 656224 | L 656224 is a 5-lipoxygenase (5-LO) inhibitor. Synonyms: L-656224. Grades: ≥98% by HPLC. CAS No. 102612-16-8. Molecular formula: C20H21ClO3. Mole weight: 344.8. | |
| L-689,560 | L-689,560 is a potent antagonist at the glycine-NMDA receptor site. It is a bioactive chemical. Synonyms: L689560; L 689560; L-689560; trans-(±)-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; rel-(2R,4S)-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; (2R,4S)-rel-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; trans-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline; (2S,4R)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 139051-78-8. Molecular formula: C17H15Cl2N3O3. Mole weight: 380.23. | |
| L 691816 | L 691816 is a 5-lipoxygenase (5-LO) inhibitor. Synonyms: 1-(4-Chlorobenzyl)-2-(2,2-Dimethyl-3-(1H-Tetrazol-5-Yl)Propyl)-4-Methyl-6-((5-Phenylpyridin-2-Yl)Methoxy)-4,5-Dihydro-1H-Thiopyrano[2,3,4-Cd]Indole; L-691816; L691816. Grades: ≥98% by HPLC. CAS No. 150461-07-7. Molecular formula: C36H35ClN6OS. Mole weight: 635.2. | |
| L-692,585 | L-692,585 is a non-peptide, highly potent and selective ghrelin receptor (GHS-R1a) agonist with Ki value of 0.8 nM. It shows GH-secretory activity in several species including human. It increases plasma GH levels in vivo and is 2-2.5-fold more potent than GHRP-6. Synonyms: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; [R-(R*,R*)]-3-[(2-hydroxypropyl)amino]-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; 1H-1-Benzazepine, Butanamide derivative; L 692585; L692585; L-692585. Grades: ≥98% by HPLC. CAS No. 145455-35-2. Molecular formula: C32H37N7O3. Mole weight: 567.69. | |
| L-693,403 maleate | L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and belongs high affinity σ ligand. It is used for the treatment of diabetes-associated pain. Synonyms: L-693,403 maleate; L 693,403 maleate; L693,403 maleate; N-1'-Benzyl-3,4-dihydrospiro[1H-indene-1,4'-piperidine] Maleate; 2,3-Dihydro-1'-(phenylmethyl)-spiro[1H-indene-1,4'-piperidine] (Z)-2-Butenedioate. CAS No. 207455-21-8. Molecular formula: C24H27NO4. Mole weight: 393.48. | |
| L-694,247 | L-694,247 is a highly selective and extremely potent 5-HT1D receptor agonist. Synonyms: L-694,247; L 694,247; L694,247. N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]methanesulfonamide; 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine. Grades: ≥98% by HPLC. CAS No. 137403-12-4. Molecular formula: C20H21N5O3S. Mole weight: 411.48. | |
| L-701,252 | L-701,252 is an antagonist at the glycine-NMDA site with IC50 value of 420 nM. It is used as a potent systemic anticonvulsant. Synonyms: L-701,252; L 701,252; L701,252; 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone. Grades: ≥99% by HPLC. CAS No. 151057-13-5. Molecular formula: C13H10ClNO3. Mole weight: 263.68. | |
| L-701,324 | L-701,324 is a selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 shows a beneficial action in the animal model of parkinsonian rigidity. L-701,324 is also a anticonvulsant which has a reduced propensity to activate mesolimbic dopaminergic systems in rodents. Preclinical trials for the treatment of Anxiety disorders, Epilepsy, Major depressive disorder and Psychotic disorders were discontinued. Uses: Anxiety disorders; epilepsy; major depressive disorder; psychotic disorders. Synonyms: L701324; L 701324; L-701324; L701324; L 701324; L-701324; 7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE;7-CHLORO-4-HYDROXY-3-(3-PHENOXY )PHENYLQUINOLIN-2[1H]-ONE. Grades: 98 %. CAS No. 142326-59-8. Molecular formula: C21H14ClNO3. Mole weight: 363.79. | |
| L-703,664 succinate | L-703,664 succinate is the succinate salt of L-703,664, which is a 5-HT1D receptor agonist. It shows selectivity over other 5-HT receptor subtypes and other receptors. Synonyms: L-703,664 succinate; L 703,664 succinate; L703664 succinate; N,N-Dimethyl-5-[(5-methyl-1,2,5-thiadiazolidin-2-yl)methyl]-S,S-dioxide-1H-indole-3-ethanamine Butanedioate; N,N-Dimethyl-5-[(5-methyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine Butanedioate; 1H-Indole-3-ethanamine-1,2,5-thiadiazolidine Derivative; N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate. Grades: ≥99% by HPLC. CAS No. 144776-01-2. Molecular formula: C20H30N4O6S. Mole weight: 454.54. | |
| L-732,138 | L-732,138 is a highly selective and potent substance P (SP) receptor antagonist. It is also a potent and competitive tachykinin NK1 receptor antagonist with IC50 value of 2.3 nM. It is also approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors. Synonyms: 3,5-bis(TFM)Bz NAcTrp; L732138; L 732138; L-732138; L-732, 138; N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl Ester; N-Acetyltryptophan 3,5-bis(trifluoromethyl)benzyl Ester. Grades: ≥98% by HPLC. CAS No. 148451-96-1. Molecular formula: C22H18F6N2O3. Mole weight: 472.39. | |
| L-733,060 | L-733,061, a phenylpiperidine derivative, has been found to be a NK1 receptor antagonist that could probably be antidepressant/ anxiolytic agent and also show antitumor activity at some extent. Uses: Neurokinin-1 receptor antagonists. Synonyms: L-733060; L 733060; L 733061; L-733061; L 733,060; L 733,061; (2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine. Grades: 98%. CAS No. 148700-85-0. Molecular formula: C20H19F6NO. Mole weight: 403.36. | |
| L-733,060 hydrochloride | The hydrochloride salt form of L-733,061, a phenylpiperidine derivative, has been found to be a NK1 receptor antagonist that could probably be antidepressant/ anxiolytic agent and also show antitumor activity at some extent. Ki: 0.08, 0.2 and 93.13 nM for gerbil, human and rat receptors, respectively. Synonyms: L-733,061 hydrochloride; MLS-002153399; L-733,060 hydrochloride; L 733,061 hydrochloride; MLS 002153399; L 733,060 hydrochloride; L733,061 hydrochloride; MLS002153399; L733,060 hydrochloride; L733061 hydrochloride; L733060 hydrochloride; (2R,3R)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride; SMR001230778. Grades: 98%. CAS No. 148687-76-7. Molecular formula: C20H19F6NO.HCl. Mole weight: 439.82. | |
| L-741,626 | L-741,626 is a selective and potent D2 dopamine receptor antagonist. It is centrally active following systemic administration in vivo. It inhibits quinpirole-stimulated mitogenesis transfected with human D2 and D3 receptors in a functional assay. It reversibly blocks D2-mediated currents in Xenopus oocytes by G protein-gated inwardly rectifying K+ (GIRK) channels. It inhibits the conditioned avoidance response (CAR) in rats and apomorphine-induced climbing behavior in mice. It evokes a catalepsy response and blocks gnawing induced by methylphenidate in rat models of potential extrapyramidal activity. Uses: Dopamine antagonists. Synonyms: L-741,626; L741,626; L 741,626; 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol; 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole; 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol; (±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole. Grades: ≥98% by HPLC. CAS No. 81226-60-0. Molecular formula: C20H21ClN2O. Mole weight: 340.85. | |
| L-741,742 hydrochloride | L-741,742 hydrochloride is the hydrochloride salt of L-741,742, which is a highly selective and potent D4 dopamine receptor antagonist with Ki value of 3.5 nM at cloned human D4 receptors. It is used in the treatment of psychological diseases such as schizophrenia and depression. Synonyms: L-741,742 hydrochloride; L741,742 hydrochloride; L 741,742 hydrochloride; 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 874882-93-6. Molecular formula: C23H26N2Cl2O. Mole weight: 417.38. | |
| L-745,870 trihydrochloride | L-745,870 trihydrochloride is the trihydrochloride salt of L-745,870, which is highly selective and potent D4 dopamine receptor antagonist with Ki value of 0.51nM. It is > 1000-fold selective over 5-HT2, D1 and D5 receptors. It has antipsychotic effects in animal models, but it was not effective in human trials. Synonyms: L-745,870 trihydrochloride; L 745,870 trihydrochloride; L745,870 trihydrochloride; 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride. Grades: ≥99% by HPLC. CAS No. 866021-03-6. Molecular formula: C18H22N4Cl2. Mole weight: 436.21. | |
| L-748,337 | L-748,337 is a selective and competitive β3-adrenoceptor antagonist with Ki value of 4.0 nM. It can inhibit agonist-induced relaxation of smooth muscle and lipolysis in rhesus monkey adipocytes. It also inhibits cAMP accumulation in response to isoproterenol. It reduces apoptosis, iNOS expression and attenuates nitric oxide-induced cell proliferation in a melanoma cell line. Synonyms: L-748337; L 748337; L748337. N- [ [3- [ (2S) -2-Hydroxy-3- [ [2- [4- [ (phenylsulfonyl) amino] phenyl] ethyl] amino] propoxy] phenyl] methyl] -acetamide. Grades: ≥98% by HPLC. CAS No. 244192-94-7. Molecular formula: C26H31N3O5S. Mole weight: 497.61. | |
| L-759,633 | L-759,633 is a potent cannabinoid receptor (CB2) agonist with 163-fold selectivity for CB2 over CB1. L-759,633 exhibits great potency against forskolin-stimulated cyclic AMP production in CB2-transfected cells than in CB1-transfected cells. Synonyms: (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene. Grades: ≥98%. CAS No. 174627-50-0. Molecular formula: C26H40O2. Mole weight: 384.6. | |
| L760735 | L760735 is a high-affinity NK1 receptor antagonist with IC50 value of 0.19 nM. It is selective over NK2 and NK3 receptors. It is used in the synthetic preparation of a (triazolylmethyl)morpholine derivative as substance P antagonist. It has anxiolytic and antidepressant-like effects and is orally active. Synonyms: L760735; L 760735; L-760735; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine Hydrochloride; [2R-[2α(R*),3α]]-5-[[2-[1-[3,5-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine Monohydrochloride. Grades: ≥99% by HPLC. CAS No. 188923-01-5. Molecular formula: C26H29F7N5O2Cl. Mole weight: 611.98. | |
| L-768242 | L-768242, an indole derivative, has been found to be a CB2 receptor agonist and was once studied to exhibit anti-nociceptive and antihyperalgesic activities in neuropathic and inflammatory pain models. Synonyms: L-768242; L768242; L 768242; GW-405833; GW405833. GW 405833; (2,3-Dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone; (2,3-dichlorophenyl)(5-methoxy-2-methyl-3-(2-morpholinoethyl)-1H-indol-1-yl)methanone; GW405833. Grades: 98%. CAS No. 180002-83-9. Molecular formula: C23H24Cl2N2O3. Mole weight: 483.82. | |
| L-771688 | L-771688, also known as SNAP 6383, is a new potent and highly selective α1A-adrenoceptor antagonist with 500-fold selective over α1B and α1D-adrenoceptors. Synonyms: methyl (4S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-[3-(4-pyridin-2-ylpiperidin-1-yl)propylcarbamoyl]-1,4-dihydropyrimidine; 5-carboxylate; L 771,688; L 771688; L-771,688; L-771688; methyl 4-(3,4-difluorophenyl)-6-((methyloxy)methyl)-2-oxo-3-((((3-(4-2-pyridinyl)-1-piperidinyl)propyl)amino)carbonyl)-1,2,3,4; tetrahydro-5-pyrimidinecarboxylate; SNAP 6383; SNAP-6383. CAS No. 200050-59-5. Molecular formula: C28H33F2N5O5. Mole weight: 557.59. | |
| L-779450 | L-779450 is a potent, selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM). L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf. Synonyms: L-779450; L779450; L 779450; L-779,450; L 779,450; L779,450. Grades: >98%. CAS No. 303727-31-3. Molecular formula: C20H14ClN3O. Mole weight: 347.8. | |
| L791943 | L791943 is a highly potent and metabolically stable PDE4 inhibitor with good in vitro activity (IC50= 4.2 nM). L-791, 943 is potent in vitro and in vivo as demonstrated by the inhibition of antigen-induced bronchoconstriction in a variety of models.The compound is well absorbed and is well tolerated in the ferret. Synonyms: L791943; L 791943; L-791943; 2-[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol; L-791,943; L-791943. CAS No. 192767-01-4. Molecular formula: C24H17F10NO4. Mole weight: 573.38. | |
| L-803,087 trifluoroacetate | L-803,087 trifluoroacetate is the trifluoroacetate salt of L-803,087, which is a selective and potent somatostatin sst4 receptor agonist often overexpressed in tumours. Its Ki value is 0.7 nM for cloned human sst4. It is a potential therapeutic target. It can be used to study signaling pathways related to somatostatin receptors. It increases kainate-induced seizures in mice in vivo and facilitates AMPA-mediated hippocampal synaptic responses in vitro. Synonyms: L-803,087 trifluoroacetate; L 803,087 trifluoroacetate; L803,087 trifluoroacetate; N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate. Grades: ≥97% by HPLC. CAS No. 217480-26-7. Molecular formula: C27H30F5N5O5. Mole weight: 599.56. | |
| L-817,818 | L-817,818 is a selective and potent somatostatin sst5 receptor agonist with Ki value of 0.4 nM for cloned human sst5 receptors. It inhibits insulin release from mouse pancreatic islets and growth hormone release from rat pituitary cells and in vitro. Synonyms: L-817,818; L 817,818; L817,818. N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester; L817818; [(2S)-2-aminopropyl] (2S)-6-amino-2-[[2-(2-naphthalen-2-yl-1H-benzo[g]indol-3-yl)acetyl]amino]hexanoate. Grades: ≥99% by HPLC. CAS No. 217480-27-8. Molecular formula: C33H36N4O3. Mole weight: 536.67. | |
| L-826,266 | L-826,266 is a potent and selective EP3 receptor antagonist. Synonyms: (E)-N-(5-Bromo-2-methoxyphenyl)sulfonyl-3-[5-chloro-2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide. Grades: ≥98%. CAS No. 244101-03-9. Molecular formula: C27H21BrClNO4S. Mole weight: 570.9. | |
| L-838,417 | L-838,417 is a subtype-selective GABAA receptor partial agonist. It selectively binds to α2, α3 and α5 subunits with Ki values of 0.67, 0.67 and 2.25 nM respectively, but it shows no efficacy at α1 (α1-sparing). It shows non-sedative antinociceptive, anxiolytic and anti-inflammatory activity in vivo. It was developed by Merck. Uses: Gaba-a receptor agonists. Synonyms: L838417; L 838417; L-838417; 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine; 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole; L-838417. Grades: ≥98% by HPLC. CAS No. 286456-42-6. Molecular formula: C19H19F2N7O. Mole weight: 399.40. | |
| L-902,688 | L-902,688 is a highly potent agonist of the human PGE2 receptor subtype EP4. It attenuated right ventricular fibrosis in a monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) rat model. L-902,688 exhibits a neuroprotective effect on ischemic stroke by reducing MMP-3/-9 and BBB damage. Synonyms: (5R)-5-[(E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one. Grades: ≥98%. CAS No. 634193-54-7. Molecular formula: C21H27F2N5O2. Mole weight: 419.5. | |
| Labetalone hydrochloride | Labetalone is an alpha- and beta-adrenergic receptor antagonist that is used as an antihypertensive. Synonyms: Labetalone HCl; 2-hydroxy-5-[2-(4-phenylbutan-2-ylamino)acetyl]benzamide hydrochloride. CAS No. 96441-14-4. Molecular formula: C19H22N2O3·HCl. Mole weight: 362.85. | |
| Lactacystin | Lactacystin is a microbial metabolite isolated from streptomyces. It is a 20S proteasome inhibitor. Synonyms: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester. Grades: ≥95%. CAS No. 133343-34-7. Molecular formula: C15H24N2O7S. Mole weight: 376.42. | |
| Ladostigil | Ladostigil, also called as TV-3,326, is a novel neuroprotective agent developed to treat neurodegenerative disorders sunch as Alzheimer's disease. Ladostigil is a dual acetylcholine-butyrylcholineesterase and brain selective monoamine oxidase (MAO)-A and -B inhibitor in vivo (with little or no MAO inhibitory effect in the liver and small intestine). Synonyms: [(3R)-3-(prop-2-ynylamino)-2,3-dihydro-1H-inden-5-yl] N-ethyl-N-methylcarbamate; (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate; Ladostigil; TV 3326; TV3326; TV-3326. Grades: >98%. CAS No. 209394-27-4. Molecular formula: C16H20N2O2. Mole weight: 272.348. | |
| Ladostigil tartrate | Ladostigil, also called as TV-3,326, is a novel neuroprotective agent developed to treat neurodegenerative disorders sunch as Alzheimer's disease. Ladostigil is a dual acetylcholine-butyrylcholineesterase and brain selective monoamine oxidase (MAO)-A and -B inhibitor in vivo (with little or no MAO inhibitory effect in the liver and small intestine). Uses: A novel brain-selective mao inhibitor, ladostigil can selectively reverse the behavioral and neurochemical effects induced by prenatal stress without affecting the behavior of controls. antidepressant. Synonyms: ethylmethyl-carbamic acid (3r)-2,3-dihydro-3-(2-propynylamino)-1h-inden-5-yl ester (2r,3r)-2,3-dihydroxybutanedioate (2:1); ladostigil tartrate; Ethylmethyl-carbamic acid (3R)-2,3-dihydro-3-(2-propynylamino)-1H-inden-5-yl ester (2R,3R)-2,3-dihydroxybutaned. Grades: >98%. CAS No. 209394-46-7. Molecular formula: 2(C16H20N2O2).C4H6O6. Mole weight: 694.78. | |
| L-α-Methyl DOPA Hydrate | L-α-Methyl DOPA Hydrate is an alpha-adrenergic agonist used as a sympatholytic or antihypertensive. Uses: Antihypertensive agent. Synonyms: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;hydrate; 3-Hydroxy-α-methyl-L-tyrosine Hydrate; (-)-α-Methyldopa Hydrate. Grades: >98%. CAS No. 41372-08-1. Molecular formula: C10H13NO4.3/2H2O. Mole weight: 238.241. | |
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